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257 results on '"Furuse, Akira"'

82. Analysis of cardiac assistance by latissimus dorsi cardiomyoplasty with a time varying elastance model.

Author

Sugiura, Seiryo, Harada, Kazumasa, Yokoyama, Ikuo, Momomura, Shin-ichi, Naruse, Yosihiro, Maku-uchi, Haruo, Serizawa, Takashi, Matsunaga, Hitoshi, Iizuka, Masahiko, Furuse, Akira, and Sugimoto, Tsuneaki

Abstract

Objective: The clinical use of skeletal muscle cardiomyoplasty is limited because of its inadequate haemodynamic benefits. To facilitate experimental and clinical efforts to improve the efficacy of this technique, a mathematical model was proposed and its validity was tested in acute experiments. Methods: The model was based on the assumption that the skeletal muscle wrapped around the heart behaves as a time varying elastance that is connected in series with another time varying elastance representing the native heart. From this model two predictions were made: (1) Skeletal muscle augments the contractility of the heart by increasing the slope (Ees) of the end systolic pressure-volume relation; (2) time varying elastance of the skeletal muscle chamber (Es(t)) can be estimated from that of the assisted heart. These predictions were examined in experiments. In nine anaesthetised, open chest dogs, preconditioned latissimus dorsi muscle was transposed to wrap the heart. Left ventricular pressure (catheter tipped micromanometer), and volume (conductance catheter) were measured while reducing the preload by vena caval occlusion to evaluate Ees with 1:2 (stimu1ation:heart beat ratio) stimulation of the skeletal muscle. Results: With the stimulation of latissimus muscle, the end systolic pressure-volume relation was linear and Ees increased from 8.6(SEM 2.4) to 11.9(SEM 3.4) mm Hg·ml−1. Estimated Es(t) reflected the stimulation pattern and could account for the mechanism of the cardiac assistance. Conclusions: Skeletal muscle cardiomyoplasty improved the haemodynamic variable (Ees) as predicted by a mathematical model.Cardiovascular Research 1993;27:997-1003 [ABSTRACT FROM PUBLISHER]

Published
1993

83. Studies on the ocular hypotensive effect of Diamox

Author

Akagi, Goro, Yamamoto, Kakuji, Furuse, Akira, and Waki, Masatoshi

Subjects
sense organs
Abstract

In our studies on the hypotensive effect of Diamox by intravenous injection, we have arrived at the following conclusions. 1. Ocular tension falls and the flow of aqueous humor becomes sluggish. 2. Diamox inhibits the activity of carbonic anhydrase, and the concentrations of HCO3-, K+, Cl- and glucose are markedly altered. 3. Protein increases both in blood and aqueous humor, but no change in protein fraction can be observed in blood. 4. Diamox in no way affects the metabolism. 5. It seems that Diamox brings about the change in the specific gravity of blood, making the latter either more diluted or more concentrated. From these, we conclude that the mechanism of the loweing of ocular tension by Diamox seems to lie in the fact that it inhibits the activity of carbonic anhydrase, and that consequent alteration in the concentrations of HCO3- and other ions accompanied by the change in osmotic pressure as well as a slight decrease of water in tissue all bring about the fall in the ocular tension. However, Diamox seems to have nothing to do with aqueous humor in so far as active transport or permeability are concerned.

Published
1959

84. Thoracoscopic Cardiomyoplasty: a Canine Feasibility Study

Author

Kaneko, Yukihiro, Ezure, Masahiko, Inaba, Hirotaka, Tambara, Keiichi, Kohno, Tadasu, and Furuse, Akira

Abstract

Background. Thoracoscopy may be effective in reducing the surgical stress of cardiomyoplasty. The feasibility of thoracoscopy in cardiomyoplasty was investigated.

Published
1997
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85. Doppler analysis of flow velocity profile at the aortic root

Author

Mathison, Megumi, Furuse, Akira, and Asano, Kenichi

Abstract

This study of aortic root flow velocity profiles suggests that the flow velocity pattern is parabolic rather than flat as has been widely supposed. To analyze the distribution of flow velocity, a special ultrasound pulsed Doppler velocity flow meter, with a direct probe on the aortic wall, was designed. Sixteen patients, none with a diagnosis of aortic valve disease, were examined just before undergoing open heart surgery. Parabolic velocity patterns were always found, and it was determined that the parabola was skewed rightward toward the anterior wall. Furthermore, it was shown that the flow velocity vector was initially directed toward the commissure of the right coronary and the noncoronary cusps.

Published
1988
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