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68. Oral Spherical Adsorptive Carbon for the Treatment of Intractable Anal Fistulas in Crohnʼs Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Author

Fukuda, Yoshihiro, Takazoe, Masakazu, Sugita, Akira, Kosaka, Tadashi, Kinjo, Fukunori, Otani, Yoshimasa, Fujii, Hisao, Koganei, Kazutaka, Makiyama, Kazuya, Nakamura, Toshio, Suda, Takeyasu, Yamamoto, Shojiro, Ashida, Toshifumi, Majima, Akira, Morita, Norikazu, Murakami, Kazunari, Oshitani, Nobuhide, Takahama, Kazuya, Tochihara, Masahiro, Tsujikawa, Tomoyuki, and Watanabe, Makoto

Published
2008

73. Mongolian Gerbils Model

Author

Shimoyama, Takashi, primary, Sakagami, Takashi, additional, Yamamoto, Noriyasu, additional, Sawada, Yukio, additional, Fukuda, Yoshihiro, additional, Tanida, Noritoshi, additional, Sashio, Hiroko, additional, and Tamura, Kazuo, additional

Published
2002
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77. Abstracts of selected papers presented at the 79th general meeting of the Japanese Society of Gastroenterology March 29–31, 1993, Kyoto, Japan

Author

Uehara, Akira, Namiki, Masayoshi, Yoneda, Masashi, Taché, Yvette, Suzuki, Hidekazu, Miura, Soichiro, Otaka, Michiro, Masamune, Osamu, Fukudo, Shin, Nomura, Taisuke, Abe, R., Shimosegawa, T., Nakamura, Keiya, Aoike, Akira, Yamaguchi, Hiroya, Kimura, Toshinari, Nakamura, Toshikazu, Matsumoto, Kunio, Tomiya, Tomoaki, Fujiwara, Kenji, Mori, Kenji, Yasunaga, Mitsuru, Yasuda, Hiroshi, Kojima, Itaru, Ohnishi, Hiroo, Nagaki, Masahito, Koide, Norio, Tsuji, Takao, Nagano, Kouichi, Kawano, Sunao, Kihira, Ken, Satoh, Kiichi, Sakaki, Nobuhiro, Yamada, Yoshiya, Karita, Mikio, Yoshimatsu, Tateo, Nakashima, Takatoshi, Aoyama, Nobuo, Fukuda, Yoshihiro, Tamura, Kazutami, Sugiyama, T., Yabana, T., Lin, Jaw-Town, Sueoka, Nobuo, Iwakiri, Katsuhiko, Watanabe, Sumio, Sato, Nobuhiro, Yamasaki, Kazuaki, Okazaki, Kazuichi, Nishino, Hirokazu, Muroi, Tadaki, Matsuda, Yoshiro, Tsutsumi, Mikihiro, Oshita, Masahide, Takei, Yoshiyuki, Kumashiro, Ryukichi, Tanikawa, Kyuichi, Nagao, Yasuyuki, Okanoue, Takeshi, Tsukada, Nobuhiro, Oda, Masaya, Ishii, Motoyasu, Yamamoto, Takeshi, Komatsu, Masafumi, Nakajima, Ko, Sakisaka, Shotaro, Tanikawa, Kyuichi, Itoh, Fumio, Imai, Kohzoh, Shintani, Yutaka, Bamba, Tadao, Saito, Eiichi, Ogihara, Akifumi, Bamba, Tadao, Sasaki, Masaya, Fujimoto, Kazuma, Iwakiri, Ryuichi, Hosomi, Motonobu, Takada, Fumio, Obayashi, Makoto, Kitano, Atushi, Nagoshi, Sumiko, Fujiwara, Kenji, Tanaka, T., Monna, T., Matsuzaki, Yutaka, Sugimoto, Hiroyuki, Machishi, Hideki, Mizumoto, Ryuji, Matsuda, Kazuya, Uchida, Yoshihito, Okano, H., Aoyama, N., Yamada, Masahiko, Hongo, Michio, Shibata, Yoshihisa, Miyachi, Masahiko, Nimura, Yuji, Neya, Toshiaki, Mizutani, Masatoshi, Inoue, Jun, Nakamura, Masahiko, Aoyama, Nobuo, Futami, Sachiko, Funakoshi, K., Sugimura, K., Iwao, Yasushi, Hibi, Toshifumi, Kusugami, Kazuo, Morise, Kimitomo, Kimura, Mitsuo, Hiwatashi, Nobuo, Kanzaki, Shinichiro, Makiyama, Kazuya, Yamamura, Makoto, Satomi, Masamichi, Harada, Hirofumi, Shimada, Hiroshi, Yoshida, Norimasa, Yoshikawa, Toshikazu, Hiraishi, Hideyuki, Harada, Takashi, Suzuki, Masayuki, Miura, Soichiro, Masuda, E., Kawano, S., Matsui, H., Fukutomi, H., Oshitani, Nobuhide, Kitano, Atsuo, Suematsu, Makoto, Suzuki, Hidekazu, Togashi, Hitoshi, Shinzawa, Haruhide, Murakami, Hiroya, Takagi, Hiroshi, Kasugai, Hiroshi, Tatsuta, Masaharu, Urabe, Takeshi, Unoura, Masashi, Yamanaka, Naoki, Okamoto, Eizo, Takayama, Tadatoshi, Yamasaki, Susumu, Kita, Kazuhiko, Ebara, Masaaki, Majima, Yasuo, Tanikawa, Kyuichi, Matsui, Osamu, Demachi, Hiroshi, Seki, Toshihito, Inoue, Kyoichi, Ohnishi, Kunihiko, Ito, Susumu, Kaneko, Akira, Hayashi, Norio, Yoneyama, Keiichiro, Mitamura, Keiji, Higashi, Katsuyoshi, Hoshino, Makoto, Ogasawara, Hisataka, Sirahama, Keigo, Hashimoto, Naoki, Yamada, Haruki, Shiratori, Yasushi, Okano, Ken’ichi, Minemura, Masami, Watanabe, Akiharu, Masaki, Tsutomu, Tokuda, Masaaki, Kawano, Tatsuyuki, Endo, Mitsuo, Kouzu, Teruo, Sakaguchi, Humiaki, Hanyu, Nobuyoshi, Aoki, Teruaki, Shimamoto, Chikao, Hirata, Ichiro, Sasajima, Koji, Takubo, Kaiyo, Kawaura, Yukimitsu, Kawakami, Kazuyuki, Hayashi, Hiroto, Suzuki, Takashi, Watanabe, Kazuo, Watanabe, Hidenobu, Hino, Naoki, Higashi, Toshihiro, Shiro, Tomohiro, Inoue, Kyoichi, Hongo, Yasushi, Tada, Hideki, Saitoh, K., Akiyama, Y., Mitsufuji, Shoji, Tsuchihashi, Yasunari, Nishimura, K., Hosokawa, Y., Wada, Ryo, Suda, Kouichi, Mafune, Ken-ichi, Idezuki, Yasuo, Mizuno, Motowo, Tsuji, Takao, Watanabe, Mamoru, Hibi, Toshifumi, Matsumoto, Takayuki, Kobayashi, Kenzo, Morise, Kimitomo, Yamaguchi, Takeo, Watanabe, T., Kubota, Y., Andoh, Akira, Fujiyama, Yoshihide, Tanaka, Kanji, Hioki, Koshirou, Hinoda, Yuji, Imai, Kohzoh, and Ohtani, Haruo

Published
1993
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78. Abstracts of selected papers presented at the 78th general meeting of the Japanese Society of Gastroenterology

Author

Kusano, Motoyasu, Sekiguchi, Toshikazu, Hanyu, Nobuyoshi, Aoki, Teruaki, Matsushima, Yasuhiro, Okamoto, Eizo, Takeda, Yasuo, Takeda, Ryoyu, Miyachi, Masahiko, Nimura, Yuji, Arai, Taidoh, Masuda, Jun, Tanaka, Masao, Ogawa, Yoshiaki, Ura, Kazuhide, Matsumoto, Teiji, Taniyama, K., Kurosawa, Susumu, Owyang, Chung, Baba, Hiroshi, Fujimura, Masaki, Hamada, Eiji, Shimada, Tadahito, Kabemura, Teppei, Chijiiwa, Yoshiharu, Sato, T., Koito, K., Matsuda, Hiroko, Kawasaki, Tsunehisa, Obara, Katsutoshi, Kasukawa, Reiji, Miyoshi, Hirofumi, Matsumoto, Akio, Yamamoto, Manabu, Ohmasa, Ryouji, Kokubu, Shigehiro, Shibata, Hisao, Tajiri, Takashi, Onda, Masahiko, Hashizume, Makoto, Sugimachi, Keizo, Kobayashi, Kenji, Shiozaki, Hitoshi, Fujisaki, Junko, Shimoda, Tadakazu, Hase, Satoshi, Tsukamoto, Yoshihisa, Atsumi, M., Konishi, H., Nakajo, Shinobu, Fujiyama, Yoshihide, Taruishi, Masaki, Ayabe, Tokiyoshi, Morise, Kimitomo, Yamaguchi, Takeo, Makiyama, Kazuya, Itsuno, Minoru, Matsui, T., Okabe, N., Okabe, Nobuo, Matsui, Toshiyuki, Sakatani, Arata, Koizumi, Koichi, Imai, Yutaka, Sugino, Yoshinori, Masaki, Tadahiko, Sawada, Toshio, Nishigami, Takashi, Satomi, Masamichi, Hatada, Yasumasa, Saito, Hiroshi, Kobayshi, Kiyonori, Katsumata, Tomoe, Sugimoto, Kenji, Itabashi, Tsukasa, Kitagawa, Motoji, Hayakawa, Tetsuo, Okazaki, Kazuichi, Yamamoto, Yasuro, Funakoshi, Akihiro, Miyasaka, Kyoko, Soejima, Kazuhiko, Kanda, Mikio, Sugiyama, Masanori, Kuroda, Akira, Inoue, Hisayuki, Bamba, Tadao, Hamanaka, Y., Suzuki, T., Suzuki, Mamoru, Hanyu, Fujio, Tamura, Katsuhiro, Nakase, Akira, Noguchi, M., Hiwatashi, N., Murata, Yuhji, Suzuki, Kazuo, Ohtani, Haruo, Watanabe, Yoshihisa, Zeniya, Mikio, Aizawa, Yoshio, Masumoto, T., Onji, M., Hamasaki, Keisuke, Nakata, Keisuke, Fukui, Hiroshi, Tsujii, Tadasu, Yamashiki, Masayoshi, Nishimura, Akira, Tsutsui, Hiroko, Mizoguchi, Yasuhiro, Kimura, Fumio, Miyazaki, Masaru, Kiyota, Keisuke, Inokuchi, Hideto, Yamamoto, Yoshihiro, Oka, Hiroshi, Horikoshi, Tsutomu, Sekiguchi, Toshikazu, Takayasu, H., Shirai, T., Hongo, Michio, Okuno, Yo, Okano, H., Aoyama, N., Ohsuki, Masao, Maeda, Kenji, Haruma, Ken, Sumii, Koji, Nakai, Yoshihide, Fukunaga, Mikihiko, Kaneko, Hiroshi, Morise, Kimitomo, Okumura, Toshikatsu, Uehara, Akira, Fukuda, Yoshihiro, Satomi, Masamichi, Joh, Takashi, Itoh, Makoto, Kitagawa, Yuko, Kitajima, Masaki, Iwao, Tadashi, Toyonaga, Atsushi, Nakamura, Masahiko, Oda, Masaya, Kawamura, Yukimitsu, Dohden, Kenji, Kamiyama, Yasuhiko, Matsuno, Seiki, Hirano, Morihisa, Otsuka, Sachio, Ito, Masahiro, Sekine, Ichiro, Ogihara, Tatsuo, Sato, Nobuhiro, Uehara, Akira, Namiki, Masayoshi, Sugiura, Nobuyuki, Ebara, Masaaki, Matsuo, Naoki, Uchida, Hideo, Okada, Shuichi, Okazaki, Nobuo, Tsujii, Hirohiko, Ohsuga, Toshiaki, Abe, M., Nagata, Y., Yamasaki, Susumu, Kosuge, Tomoo, Kitamoto, Mikiya, Nakanishi, Toshio, Ichikawa, Yuzo, Mizoguchi, Yasuhiro, Ohtake, Yoshio, Hirasawa, Hiroyuki, Sugihara, Junichi, Muto, Yasutoshi, Yasunaga, Mitsuru, Okita, Kiwamu, Ukida, Minoru, Tsuji, Takao, Isai, Hideya, Uchino, Junichi, Suzuki, Katsuhiko, Komatsu, Kanji, Ohtomo, Yumiko, Idezuki, Yasuo, Sakuramachi, Shunji, Kimura, Taizo, Kitano, Seigo, Sugimachi, Keizo, Moriyama, Masaaki, Yazaki, Yasuyuki, and Saito, Takashige

Published
1993
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83. Abstracts of selected papers presented at the 32nd Annual Meeting of the Japanese Society of Gastroenterology

Author

Sata, Naohiro, Atomi, Yutaka, Ohshio, Gakuji, Manabe, Tadao, Watanabe, Shin-ichiro, Takeuchi, Tadashi, Miyasaka, Kyoko, Funakoshi, Akihiro, Hayakawa, Tetsuo, Nagai, Kenji, Murata, Atsuo, Ogawa, Michio, Takeda, Kazunori, Matsuno, Seiki, Tomiya, Tomoaki, Fujiwara, Kenji, Nakamura, Toshio, Nakanishi, Toshio, Sasaki, Iwao, Matsuno, Seiki, Yoshino, Keiichi, Makuuchi, Hiroyasu, Sawaguchi, Yuji, Uchino, Junichi, Yokoi, Hajime, Kawarada, Yoshifumi, Komatsu, Hirokazu, Oda, Masaya, Komada, Toshiyuki, Kitami, Noriyuki, Sato, Nobuhiro, Inada, Masami, Kawata, Sumio, Koga, Michiaki, Yano, Michitami, Takano, Susumu, Omata, Masao, Yasunaga, Mitsuru, Shirasawa, Hiroyuki, Ouchi, Kiyoaki, Matsuno, Seiki, ASakura, Hitoshi, Okabe, Nobuo, Yao, Tsuneyoshi, Bamba, Tadao, Fujiyama, Yoshihide, Okawa, Kiyotaka, Harihara, Shigeyoshi, Ohkusa, Toshifumi, Sasabe, Masataka, Shoji, Yasutsugu, Utsunomiya, Joji, Hayashi, S., Furukawa, T., Matsuhashi, Nobuyuki, Sugano, Kentaro, Yamazaki, Hideo, Hiwatashi, Nobuo, Ashida, Tomofumi, Ayabe, Tokiyoshi, Takazoe, Masakazu, Inoue, Noboru, Kitano, A., Kobayashi, K., Fukuda, Yoshihiro, Tamura, Kazutami, Koyama, Hiroshi, Niwa, Hirohumi, Takahashi, Shuji, Yoshikawa, Toshikazu, Mizuno, Shiuichi, Sasaki, Ei, Toyonaga, Atsushi, Okabayashi, Yoshinori, Otsuki, Makoto, Shiratori, Keiko, Watanabe, Shin-ichiro, Ozawa, Susumu, Tanaka, Shigeki, Funakoshi, Akihiro, Wakasugi, Hideyuki, Tazawa, Yusaku, Takikawa, Hajime, Kawasaki, Hironaka, Tanaka, Naomi, Kajiyama, Goro, Shimoyama, Takashi, and Kanazawa, Kyotaro

Published
1992
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85. Abstracts Of Selected Papers Presented At The 75Th General Meeting Of The Japanese Society Of Gastroenterology March 27–29, 1989 — Yokohama, Japan

Author

Tanabe, Satoshi, Saigenji, Katsunori, Asaki, Shigeru, Sato, Akira, Takeda, Isao, Nakano, Satoshi, Inoue, Yoshihiro, Kano, Atsushi, Shiina, Yasubumi, Miwa, Takeshi, Takahashi, Hiroshi, Namatame, Kimio, Sugawa, C., Nakamura, R., Uchida, Hideichi, Kodama, Tadashi, Oka, Shinji, Okazaki, Yukinori, Sato, Nobuhiro, Ogihara, Tatsuo, Niwa, Yasumasa, Nakazawa, Saburo, Azuumi, Yoshiteru, Saigenji, Katsunori, Saito, Yutaka, Sato, Kunio, Iwasaki, Ariyoshi, Abe, Masanao, Miyairi, Mamoru, Suyama, Kyoichiro, Hayakawa, Tetsuo, Suzuki, Toshiyuki, Miyake, Hirofumi, Ochi, Koji, Wakasugi, Hideyuki, Funakoshi, Akihiro, Nakano, Satoshi, Sugiyama, Keiichi, Manabe, Tadao, Baba, Nobuo, Yamamoto, Masahiro, Saitoh, Yoichi, Tamura, Kazutami, Fukuda, Yoshihiro, Sakaki, Nobuhiro, Ietomi, Katsuyuki, Yamada, Masahiro, Ohkusa, Toshifumi, Takahashi, Shinichi, Saito, Shozo, Satoh, Kiichi, Kimura, Ken, Ito, Shigeji, Kohli, Yoshihiro, Koyama, S., Bamba, T., Takagi, A., Kojima, K., Sugiyama, T., Yabana, T., Tada, Masahiro, Shigeeda, Masaki, Yoshida, M., Imoto, I., Hashiguchi, Takafumi, Shibue, Tadashi, Saita, Hiroshi, Murakami, Motonobu, Tsujii, Masahiko, Kawano, Sunao, Shirai, Takayuki, Harasawa, Shigeru, Yamamoto, Tomikazu, Nishio, Akiyoshi, Saeki, Susumu, Oh, Toumei, Tatsuta, Masaharu, Ishii, Hiroyasu, Nishiwaki, Hideki, Satake, Katsusuke, Matsuzaki, Yasushi, Tanaka, Naomi, Knakano, Akira, Fukushima, Tsuneo, Horiuchi, I., Kajiyama, G., Saito, Hideaki, Morioka, Yasuhiko, Miura, Soichiro, Yoshioka, Masahiro, and Takahashi, Naomi

Published
1991
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97. Nitrogen K-edge X-ray absorption near edge structure (XANES) spectra of purine-containing nucleotides in aqueous solution.

Author

Shimada, Hiroyuki, Fukao, Taishi, Minami, Hirotake, Ukai, Masatoshi, Fujii, Kentaro, Yokoya, Akinari, Fukuda, Yoshihiro, and Saitoh, Yuji

Subjects
NITROGEN absorption & adsorption, X-ray absorption, SPECTRUM analysis, NUCLEOTIDES, AQUEOUS solutions, HYDROGEN-ion concentration
Abstract

The N K-edge X-ray absorption near edge structure (XANES) spectra of the purine-containing nucleotide, guanosine 5'-monophosphate (GMP), in aqueous solution are measured under various pH conditions. The spectra show characteristic peaks, which originate from resonant excitations of N 1s electrons to n * orbitals inside the guanine moiety of GMP. The relative intensities of these peaks depend on the pH values of the solution. The pH dependence is explained by the core-level shift of N atoms at specific sites caused by protonation and deprotonation. The experimental spectra are compared with theoretical spectra calculated by using density functional theory for GMP and the other purine-containing nucleotides, adenosine 5'-monophosphate, and adenosine 5'-triphosphate. The N K-edge XANES spectra for all of these nucleotides are classified by the numbers of N atoms with particular chemical bonding characteristics in the purine moiety. [ABSTRACT FROM AUTHOR]

Published
2014
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98. Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood

Author

Komeda, Toshiki, Fukuda, Yoshihiro, Sando, Takehiro, Kita, Ryuichi, Furukawa, Motonobu, Nishida, Naoshi, Amenomori, Masahiro, and Nakao, Kazuwa

Subjects
Liver cancer -- Metastasis, Metastasis -- Diagnosis, Polymerase chain reaction, Health
Abstract

Background. This study was performed to develop a sensitive method for the detection of circulating hepatocellular carcinoma (HCC) cells in peripheral blood, in advance of the diagnosis of distant metastasis of HCC by conventional means. Methods. Peripheral blood (5 ml) samples were obtained from 64 patients with HCC and from 48 control subjects (31 patients with benign liver disease, 8 with metastatic liver cancer, and 9 with normal liver function). To identify HCC cells in peripheral blood, liver-specific human alpha-fetoprotein (hAFP) mRNA was amplified from total RNA extracted from whole blood by reverse transcriptase-polymerase chain reaction. Results. Human alpha-fetoprotein mRNA was detected in 23 blood samples from the HCC patients (23/64, 36%), in 17 patients in whom there was no clinical evidence of distant metastasis. In contrast, there were no control patients whose samples showed detectable hAFP mRNA in the peripheral blood. The presence of hAFP mRNA in blood seemed to be correlated with the stage (by TNM classification) of HCC, the serum hAFP value, and the presence of intrahepatic metastasis, portal vein thrombosis, and/or distant metastasis. Conclusions. Reverse-transcriptase polymerase chain reaction is a very sensitive method for detecting circulating HCC cells. With this technique, important information for the management of HCC can be acquired, such as the indications for orthotopic liver transplantation in HCC patients. Moreover, use of this detection method may encourage investigation of the mechanism of metastasis in HCC. Cancer 1995; 75:2214-9.

Published
1995

100. Liver damage in patients with colony-stimulating factor-producing tumors

Author

Suzuki, Akira, Takahashi, Takayuki, Okuno, Yoshiaki, Seko, Shuji, Fukuda, Yoshihiro, Nakamura, Kishiko, Fukumoto, Manabu, Konaka, Yoshiteru, and Imura, Hiroo

Subjects
Colony-stimulating factors (Physiology) -- Physiological aspects, Interleukin-1 -- Physiological aspects, Interleukin-6 -- Physiological aspects, Tumors -- Physiological aspects, Leukocytosis -- Diagnosis, Liver diseases -- Causes of, Health, Health care industry
Abstract

PURPOSE: We have demonstrated that colony-stimulating factor (CSF)-producing tumor cell lines produce not only CSF but also interleukin1 (IL-1) and interleukin-6 (IL-6). Clinically, we have observed that patients bearing such tumors present with liver dysfunction and fever in addition to marked leukocytosis. The purpose of this study was to determine whether or not the liver damage was specifically related to CSF-producing tumors. PATIENTS AND METHODS: Clinicopathologic examinations were performed in six autopsied patients with CSF-producing tumors. We also transplanted two tumor cell lines (KHC287 and CHU-2), which produce granulocyte (G)-CSF, IL-1, and IL-6, to nude mice. RESULTS: Of the six patients, five had G-CSF-and one had granulocyte/macrophage (GM)CSF-producing tumors. IL-1 and IL-6 concentrations in plasma or culture supernatant were elevated in these patients. Biochemical examinations revealed high serum enzyme levels of the biliary system in contrast to normal or slight increases in transaminase levels in all patients studied. Serum direct bilirubin was elevated in five of the six patients. Three common pathologic changes of the liver were found: (1) focal necrosis associated with neutrophil infiltration in the centrilobular zones, (2) fibrous change and enlargement of the portal area associated with neutrophil infiltration, and (3) intrahepatic cholestasis. The same pathologic changes, except for cholestasis, were reproduced in the liver of mice transplanted with KHC287 or CHU-2. CONCLUSION: These results indicate that patients with CSF-producing tumors have charactenstic liver damage, and suggest a new paraneoplastic syndrome of leukocytosis and liver damage.

Published
1993

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