59 results on '"Fujimoto, Tomomi"'
Search Results
52. Anomalous valence changes and specific dinitrogen adsorption features of copper ion exchanged in ZSM-5 zeolite prepared from an aqueous solution of [Cu(NH3)2]+
- Author
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Kuroda, Yasushige, primary, Itadani, Atsushi, additional, Kumashiro, Ryotaro, additional, Fujimoto, Tomomi, additional, and Nagao, Mahiko, additional
- Published
- 2004
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53. Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells.
- Author
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Yuasa, Keizo, Tada, Kaori, Harita, Genki, Fujimoto, Tomomi, Tsukayama, Masao, and Tsuji, Akihiko
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ANTI-inflammatory agents ,CITRUS sudachi ,LIPOPOLYSACCHARIDES ,CELL lines ,NITRIC oxide synthesis ,FLAVONOIDS ,LABORATORY mice - Abstract
The article discusses anti inflammatory responses of Citrus sudachi on lipopolysaccharides induced inflammatory responses in macrophage-derived mouse cell lines. It mentions that polymethoxyflavones from the fruit has inhibitory effects on the nitric oxide production which acts by suppressing the expression of inducible nitric oxide synthase. It analyzes Sudachitin as a more potent anti-inflammatory agent than nobiletin flavonoid.
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- 2012
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54. Novel Methodology for Identifying the Occurrence of Ovulation by Estimating Core Body Temperature During Sleeping: Validity and Effectiveness Study.
- Author
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Sato D, Ikarashi K, Nakajima F, and Fujimoto T
- Abstract
Background: Body temperature is the most-used noninvasive biomarker to determine menstrual cycle and ovulation. However, issues related to its low accuracy are still under discussion., Objective: This study aimed to improve the accuracy of identifying the presence or absence of ovulation within a menstrual cycle. We investigated whether core body temperature (CBT) estimation can improve the accuracy of temperature biphasic shift discrimination in the menstrual cycle. The study consisted of 2 parts: experiment 1 assessed the validity of the CBT estimation method, while experiment 2 focused on the effectiveness of the method in discriminating biphasic temperature shifts., Methods: In experiment 1, healthy women aged between 18 and 40 years had their true CBT measured using an ingestible thermometer and their CBT estimated from skin temperature and ambient temperature measured during sleep in both the follicular and luteal phases of their menstrual cycles. This study analyzed the differences between these 2 measurements, the variations in temperature between the 2 phases, and the repeated measures correlation between the true and estimated CBT. Experiment 2 followed a similar methodology, but focused on evaluating the diagnostic accuracy of these 2 temperature measurement approaches (estimated CBT and traditional oral basal body temperature [BBT]) for identifying ovulatory cycles. This was performed using urine luteinizing hormone (LH) as the reference standard. Menstrual cycles were categorized based on the results of the LH tests, and a temperature shift was identified using a specific criterion called the "three-over-six rule." This rule and the nested design of the study facilitated the assessment of diagnostic measures, such as sensitivity and specificity., Results: The main findings showed that CBT estimated from skin temperature and ambient temperature during sleep was consistently lower than directly measured CBT in both the follicular and luteal phases of the menstrual cycle. Despite this, the pattern of temperature variation between these phases was comparable for both the estimated and true CBT measurements, suggesting that the estimated CBT accurately reflected the cyclical variations in the true CBT. Significantly, the CBT estimation method showed higher sensitivity and specificity for detecting the occurrence of ovulation than traditional oral BBT measurements, highlighting its potential as an effective tool for reproductive health monitoring. The current method for estimating the CBT provides a practical and noninvasive method for monitoring CBT, which is essential for identifying biphasic shifts in the BBT throughout the menstrual cycle., Conclusions: This study demonstrated that the estimated CBT derived from skin temperature and ambient temperature during sleep accurately captures variations in true CBT and is more accurate in determining the presence or absence of ovulation than traditional oral BBT measurements. This method holds promise for improving reproductive health monitoring and understanding of menstrual cycle dynamics., (©Daisuke Sato, Koyuki Ikarashi, Fumiko Nakajima, Tomomi Fujimoto. Originally published in JMIR Formative Research (https://formative.jmir.org), 05.07.2024.)
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- 2024
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55. Effects of Pre-Exercise Voluntary Hyperventilation on Metabolic and Cardiovascular Responses During and After Intense Exercise.
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Dobashi K, Ichinose M, Fujii N, Fujimoto T, and Nishiyasu T
- Subjects
- Humans, Carbon Dioxide, Oxygen Consumption physiology, Hyperventilation, Hypocapnia metabolism
- Abstract
Purpose: We investigated the effects of pre-exercise voluntary hyperventilation and the resultant hypocapnia on metabolic and cardiovascular responses during and after high-intensity exercise. Methods : Ten healthy participants performed a 60-s cycling exercise at a workload of 120% peak oxygen uptake in control (spontaneous breathing), hypocapnia and normocapnia trials. Hypocapnia was induced through 20-min pre-exercise voluntary hyperventilation. In the normocapnia trial, voluntary hyperpnea was performed with CO
2 inhalation to prevent hypocapnia. Results : Pre-exercise end-tidal CO2 partial pressure was lower in the hypocapnia trial than the control or normocapnia trial, with similar levels in the control and normocapnia trials. Average V ˙ O 2 during the entire exercise was lower in both the hypocapnia and normocapnia trials than in the control trial (1491 ± 252vs.1662 ± 169vs.1806 ± 149 mL min-1 ), with the hypocapnia trial exhibiting a greater reduction than the normocapnia trial. Minute ventilation during exercise was lower in the hypocapnia trial than the normocapnia trial. In addition, minute ventilation during the first 10s of the exercise was lower in the normocapnia than the control trial. Pre-exercise hypocapnia also reduced heart rates and arterial blood pressures during the exercise relative to the normocapnia trial, a response that lasted through the subsequent early recovery periods, though end-tidal CO2 partial pressure was similar in the two trials. Conclusions : Our results suggest that pre-exercise hyperpnea and the resultant hypocapnia reduce V ˙ O 2 during high-intensity exercise. Moreover, hypocapnia may contribute to voluntary hyperventilation-mediated cardiovascular responses during the exercise, and this response can persist into the subsequent recovery period, despite the return of arterial CO2 pressure to the normocapnic level.- Published
- 2023
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56. Thermal Sensation After the 10-km Open-Water Swimming in Cool Water Depends on the Skin's Thermal Sensitivity Rather Than Core Temperature.
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Fujimoto T, Matsuura Y, Baba Y, and Hara R
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- Male, Humans, Female, Young Adult, Adult, Temperature, Cold Temperature, Thermosensing, Skin Temperature, Swimming, Water
- Abstract
Purpose: To assess the core temperature fluctuations during 10-km open-water swimming (OWS) in cool water and the relationship between thermal sensation (TS) after 10-km OWS, core temperature, and local skin thermal sensitivity., Methods: Nine highly trained OWS swimmers (4 female; age 22 [3] y) completed a single 10-km trial in cool water (22.3 °C) wearing swimsuits for OWS. During the trial, core temperature was continuously recorded via ingestible temperature sensors, and TS after trial was also measured. Then, local skin warm/cool sensitivity was measured in the forearm., Results: All swimmers completed the 10-km OWS. Mean swimming speed for males and females were 1.39 (1.37-1.42 m/s) and 1.33 m/s (1.29-1.38 m/s), respectively. Core temperature increased in 8 out of 9 swimmers during 10-km OWS (P = .047), with an average increase of 0.8 °C. TS after 10-km OWS varied among swimmers. There were no correlations between post-OWS TS and post-OWS core temperature (P = .9333), whereas there was a negative correlation between post-OWS TS and local skin cool sensitivity (P = .0056)., Conclusion: These results suggest that core temperature in elite swimmers might not decrease during 10-km OWS in the cool water temperature of official OWS. In addition, individual differences in TS after 10-km OWS may be related to skin cool sensitivity rather than core temperature.
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- 2023
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57. Hypocapnia attenuates local skin thermal perception to innocuous warm and cool stimuli in normothermic resting humans.
- Author
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Fujimoto T, Dobashi K, Fujii N, Matsutake R, and Nishiyasu T
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- Young Adult, Female, Humans, Skin, Skin Temperature, Perception, Hypocapnia, Hyperventilation
- Abstract
When one is exposed to a stressful situation in their daily life, a common response is hyperventilation. Although the physiological significance of stress-induced hyperventilation remains uncertain, this response may blunt perception of the stress-inducing stimulus. This study examined the effects of voluntary hyperventilation and resultant hypocapnia on the local skin thermal detection threshold in normothermic resting humans. Local skin thermal detection thresholds were measured in 15 young adults (three females) under three breathing conditions: 1 ) spontaneous breathing (Control trial), 2 ) voluntary hypocapnic hyperventilation (HH trial), and 3 ) voluntary normocapnic hyperventilation (NH trial). Local skin thermal detection thresholds were measured using thermostimulators containing a Peltier element that were attached to the forearm and forehead. The temperature of the probe was initially equilibrated to the skin temperature, then gradually increased or decreased at a constant rate (±0.1 °C/s) until the participants felt warmth or coolness. The difference between the initial skin temperature and the local skin temperature at which the participant noticed warmth/coolness was assessed as an index of the local skin warm/cool detection threshold. Local detection of warm and cool stimuli did not differ between the Control and NH trials, but it was blunted in the HH trial as compared with the Control and NH trials, except for detection of warm stimuli on the forearm. These findings suggest that hyperventilation-induced hypocapnia, not hyperventilation per se, attenuates local skin thermal perception, though changes in responses to warm stimuli may not be clearly perceived at some skin areas (e.g., forearm).
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- 2023
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58. CO 2 -Enriched Air Inhalation Modulates the Ventilatory and Metabolic Responses of Endurance Runners During Incremental Running in Hypobaric Hypoxia.
- Author
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Cao Y, Fujii N, Fujimoto T, Lai YF, Ogawa T, Hiroyama T, Enomoto Y, and Nishiyasu T
- Subjects
- Humans, Hypoxia metabolism, Lung metabolism, Male, Oxygen, Partial Pressure, Carbon Dioxide, Running
- Abstract
Cao, Yinhang, Naoto Fujii, Tomomi Fujimoto, Yin-Feng Lai, Takeshi Ogawa, Tsutomu Hiroyama, Yasushi Enomoto, and Takeshi Nishiyasu. CO
2 -enriched air inhalation modulates the ventilatory and metabolic responses of endurance runners during incremental running in hypobaric hypoxia. High Alt Med Biol . 23:125-134, 2022. Aim: We measured the effects of breathing CO2 -enriched air on ventilatory and metabolic responses during incremental running exercise under moderately hypobairc hypoxic (HH) conditions. Materials and Methods: Ten young male endurance runners [61.4 ± 6.0 ml/(min·kg)] performed incremental running tests under three conditions: (1) normobaric normoxia (NN), (2) HH (2,500 m), and (3) HH with 5% CO2 inhalation (HH+CO2 ). The test under NN was always performed first, and then, the two remaining tests were completed in random and counterbalanced order. Results: End-tidal CO2 partial pressure (55 ± 3 vs. 35 ± 1 mmHg), peak ventilation (163 ± 14 vs. 152 ± 12 l/min), and peak oxygen uptake [52.3 ± 5.5 vs. 50.5 ± 4.9 ml/(min·kg)] were all higher in the HH+CO2 than HH trial (all p < 0.01), respectively. However, the duration of the incremental test did not differ between HH+CO2 and HH trials. Conclusion: These data suggest that chemoreflex activation by breathing CO2 -enriched air stimulates breathing and aerobic metabolism during maximal intensity exercise without affecting exercise performance in male endurance runners under a moderately hypobaric hypoxic environment.- Published
- 2022
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59. Low-intensity exercise delays the shivering response to core cooling.
- Author
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Fujimoto T, Tsuji B, Sasaki Y, Dobashi K, Sengoku Y, Fujii N, and Nishiyasu T
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- Adult, Bicycling, Humans, Immersion, Male, Muscle, Skeletal metabolism, Oxygen Consumption, Time Factors, Young Adult, Exercise, Muscle Contraction, Muscle, Skeletal physiology, Shivering, Skin Temperature, Thermosensing
- Abstract
Hypothermia can occur during aquatic exercise despite production of significant amounts of heat by the active muscles. Because the characteristics of human thermoregulatory responses to cold during exercise have not been fully elucidated, we investigated the effect of low-intensity exercise on the shivering response to core cooling in cool water. Eight healthy young men (24 ± 3 yr) were cooled through cool water immersion while resting (rest trial) and during loadless pedaling on a water cycle ergometer (exercise trial). Before the cooling, body temperature was elevated by hot water immersion to clearly detect a core temperature at which shivering initiates. Throughout the cooling period, mean skin temperature remained around the water temperature (25°C) in both trials, whereas esophageal temperature (T
es ) did not differ between the trials ( P > 0.05). The Tes at which oxygen uptake (V̇o2 ) rapidly increased, an index of the core temperature threshold for shivering, was lower during exercise than rest (36.2 ± 0.4°C vs. 36.5 ± 0.4°C, P < 0.05). The sensitivity of the shivering response, as indicated by the slope of the Tes -V̇o2 relation, did not differ between the trials (-441.3 ±177.4 ml·min-1 ·°C-1 vs. -411.8 ± 268.1 ml·min-1 ·°C-1 , P > 0.05). The thermal sensation response to core cooling, assessed from the slope and intercept of the regression line relating Tes and thermal sensation, did not differ between the trials ( P > 0.05). These results suggest that the core temperature threshold for shivering is delayed during low-intensity exercise in cool water compared with rest although shivering sensitivity is unaffected.- Published
- 2019
- Full Text
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