51. Flavonoid intake and its association with atrial fibrillation
- Author
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Anne Tjønneland, Kim Overvad, Frederik Dalgaard, Jonathan M. Hodgson, Augustin Scalbert, Cecilie Kyrø, Joshua R. Lewis, Gunnar Gislason, Aedin Cassidy, Jonathan P. Piccini, Kevin Murray, Nicola P. Bondonno, Catherine P. Bondonno, and Kevin D. Croft
- Subjects
Male ,0301 basic medicine ,Denmark ,Flavonoid ,Critical Care and Intensive Care Medicine ,Eating ,0302 clinical medicine ,Atrial Fibrillation ,Medicine ,Registries ,Prospective cohort study ,chemistry.chemical_classification ,RISK ,Nutrition and Dietetics ,Primary prevention ,Incidence ,food and beverages ,Atrial fibrillation ,Middle Aged ,Cardiovascular disease ,CANCER ,Cohort ,Female ,FIBRILLATION ,medicine.medical_specialty ,Cardiovascular health ,030209 endocrinology & metabolism ,Lower risk ,Diet Surveys ,DIET ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Internal medicine ,Humans ,Proportional Hazards Models ,Nutrition ,Flavonoids ,030109 nutrition & dietetics ,business.industry ,Proportional hazards model ,medicine.disease ,Health Surveys ,Diet ,chemistry ,Heart Disease Risk Factors ,business - Abstract
Background & Aims: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF. Methods: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models. Results: During a median [IQR] follow-up of 21 [18 – 22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [
- Published
- 2020