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471 results on '"Frantellizzi, Viviana"'

55. First-, Second-, and Third-Generation Radiolabeled Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Positron Emission Tomography: State of the Art, a Systematic Review

Author

Sidrak, Marko Magdi Abdou, primary, De Feo, Maria Silvia, additional, Frantellizzi, Viviana, additional, Marongiu, Andrea, additional, Caponnetto, Salvatore, additional, Filippi, Luca, additional, Nuvoli, Susanna, additional, Spanu, Angela, additional, Schillaci, Orazio, additional, and De Vincentis, Giuseppe, additional

Published
2023
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57. Extraosseous distribution of 99mTc-diphosphonates during bone scintigraphy: review of the literature with case series presentation.

Author

Conte, Miriam, De Feo, Maria Silvia, Frantellizzi, Viviana, Marampon, Francesco, Filippi, Luca, Schillaci, Orazio, and De Vincentis, Giuseppe

Subjects
RADIONUCLIDE imaging, LITERATURE reviews, CALCIUM metabolism, CALCIPHYLAXIS
Abstract

Technetium-99m (99mTc)-diphosphonates represent the most common radiopharmaceutical used for bone scintigraphy. Even if the uptake in bone tissue has been widely explored, atypical uptake could be seen in soft tissue malignancies during bone scintigraphy. Increased vascularization and endothelium permeability represent front-row players in the biodistribution of the tracer, albeit other causes have been identified such as trauma, necrosis, the presence of calcification in metastasis, the pH of the tissue and consequently the type of ion concentration. The aim of this paper is to summarize the state of art of atypical soft tissue uptake seen in cancer tissues. The research was conducted on PubMed. The analysis of the literature suggests that calcium metabolism and ionic saturation have a pivotal role in the biodistribution of bone tracers. This phenomenon ranks in a complex scenario that includes carcinogenesis and cancer environment aspects. We also report two cases in our Institution in which atypical uptake in cancer tissues was observed. [ABSTRACT FROM AUTHOR]

Published
2024
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58. 18F-FDG PET/CT technology for the assessment of brown adipose tissue: an updated review.

Author

Ricci, Maria, De Feo, Maria Silvia, Granese, Giorgia Maria, Frantellizzi, Viviana, Carabellese, Bruno, Lubrano, Ennio, and Cimini, Andrea

Subjects
BROWN adipose tissue, TECHNOLOGY assessment, POSITRON emission tomography, TYPE 2 diabetes
Abstract

This review provides an update of 18 F-fluorodeoxyglucose ([18F] FDG) for Brown adipose tissue (BAT) activity quantification, whose role is not completely understood. We conducted an unstructured search of the literature for any studies employing the [18F] FDG PET in BAT assessment. We explored BAT quantification both in healthy individuals and in different pathologies, after cold exposure and as a metabolic biomarker. The assessment of possible BAT modulators by using [18F] FDG PET is shown. Further PET tracers and novel developments for BAT assessments are also described. Further PET tracers and imaging modalities are under investigation, but the [18F] FDG PET is currently the method of choice for the evaluation of BAT and further multicentric trials are needed for a better understanding of the BAT physiopathology, also after cold stimuli. The modulation of BAT activity, assessed by [18F] FDG PET imaging, seems a promising tool for the management of conditions such as obesity and type 2 diabetes. Moreover, an interesting possible correlation of BAT activation with prognostic [18F] FDG PET indices in cancer patients should be assessed with further multicentric trials. [ABSTRACT FROM AUTHOR]

Published
2023
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59. Abscopal Effect on Bone Metastases from Solid Tumors: A Systematic Review and Retrospective Analysis of Challenge within a Challenge

Author

Tomaciello, Miriam, primary, Conte, Miriam, additional, Montinaro, Francesca Romana, additional, Sabatini, Arianna, additional, Cunicella, Giorgia, additional, Di Giammarco, Federico, additional, Tini, Paolo, additional, Gravina, Giovanni Luca, additional, Cortesi, Enrico, additional, Minniti, Giuseppe, additional, De Vincentis, Giuseppe, additional, Frantellizzi, Viviana, additional, and Marampon, Francesco, additional

Published
2023
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61. The DASciS Software for BSI Calculation as a Valuable Prognostic Tool in mCRPC Treated with 223RaCl2: A Multicenter Italian Study

Author

De Feo, Maria Silvia, primary, Frantellizzi, Viviana, additional, Bauckneht, Matteo, additional, Farcomeni, Alessio, additional, Filippi, Luca, additional, Rizzini, Elisa Lodi, additional, Lavelli, Valentina, additional, Stazza, Maria Lina, additional, Di Raimondo, Tania, additional, Fornarini, Giuseppe, additional, Rebuzzi, Sara Elena, additional, Filippo, Mammini, additional, Mammucci, Paolo, additional, Marongiu, Andrea, additional, Monari, Fabio, additional, Rubini, Giuseppe, additional, Spanu, Angela, additional, and De Vincentis, Giuseppe, additional

Published
2023
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65. PET Criteria by Cancer Type from Imaging Interpretation to Treatment Response Assessment: Beyond FDG PET Score

Author

Dondi, Francesco, primary, Lazzarato, Achille, additional, Gorica, Joana, additional, Guglielmo, Priscilla, additional, Borgia, Francesca, additional, Filice, Rossella, additional, Vento, Antonio, additional, Pacella, Sara, additional, Camedda, Riccardo, additional, Caracciolo, Matteo, additional, De Feo, Maria Silvia, additional, Mammucci, Paolo, additional, Frantellizzi, Viviana, additional, Ortolan, Naima, additional, Fiasconaro, Elisa, additional, Urso, Luca, additional, Evangelista, Laura, additional, Laudicella, Riccardo, additional, and Santo, Giulia, additional

Published
2023
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68. Qualitative and Semiquantitative Parameters of 18F-FDG-PET/CT as Predictors of Malignancy in Patients with Solitary Pulmonary Nodule

Author

Corica, Ferdinando, primary, De Feo, Maria Silvia, additional, Stazza, Maria Lina, additional, Rondini, Maria, additional, Marongiu, Andrea, additional, Frantellizzi, Viviana, additional, Nuvoli, Susanna, additional, Farcomeni, Alessio, additional, De Vincentis, Giuseppe, additional, and Spanu, Angela, additional

Published
2023
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75. Sex differences in 123I-mIBG scintigraphy imaging techniques in patients with heart failure.

Author

Conte, Miriam, De Feo, Maria Silvia, Frantellizzi, Viviana, Di Rocco, Arianna, Farcomeni, Alessio, De Cristofaro, Flaminia, Maria, Ricci, Pisani, Antonio Rosario, Rubini, Giuseppe, and De Vincentis, Giuseppe

Subjects
HEART failure patients, RADIONUCLIDE imaging, CARDIAC patients
Abstract

123I-mIBG-scintigraphy could be a useful stratifying tool for patients with heart failure (HF). The purpose of this retrospective study is to evaluate whether there are differences between men and women with HF in terms of the prediction of cardiac arrhythmic events (AE). A total of 306 patients, before implantable-cardioverter-defibrillator (ICD) implantation, were evaluated. They underwent 123I-mIBG-scintigraphy and an evaluation of the results was performed after 85 months of follow-up. Early and late planar and SPECT cardiac images were acquired. Heart-to-mediastinum ratio (HM) for planar images and the sum of the segmental scores (SS) for SPECT were calculated. In the general population, age, early SS (ESS), late SS (LSS), and ejection fraction (EF) were statistically significant for the prediction of AE at Cox regression, while early and late HM (eHM,lHM) were not significative for the prediction of AE. Population was divided into females and males and univariate analysis was conducted separately for the two cohorts: no significant variables for prediction of AE were found in females. For males, ESS, LSS, EF, and late HM were statistically significant predictors of AE. The overall survival was similar in males and females, but the risk of AE is lower in males than in females. 123I-mIBG represents a more effective tool for the prediction of AE in male patients than in women. [ABSTRACT FROM AUTHOR]

Published
2023
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76. Dose optimization in adult pet imaging: a balance between patient exposure and image quality. Literature review and future perspectives

Author

Guglielmo, Priscilla, Laudicella, Riccardo, Rovera, Guido, Filice, Angelina, Panareo, Stefano, Chierichetti, Franca, Zorz, Alessandra, Ferretti, Stefano, Iudicello, Antonella, Frantellizzi, Viviana, Bruno, Isabella, Stracuzzi, Federica, Paiusco, Marta, Gomez, Luca Maria Colombo, and Burroni, Luca

Abstract

Purpose: the aim of our study is to collect all the measures adopted in clinical daily practice to reduce the patient dose in the different steps (injected activity, CT protocol, reconstruction methods, etc.) and to explore their advantages and limitations. Methods: a comprehensive search of relevant articles was conducted in medical databases (i.e. Embase, Scopus, Web of Science and Medline), using the keywords: dose optimization, computed tomography, PET, radiopharmaceutical, PET/CT, PET/MRI, DRL. Only English and full-text articles were included, without limitations on the year of publication. Results: after the screening, 58 articles were selected that were considered eligible for the analysis. The methods used for dose optimization include: improving reconstruction algorithms; reducing the injected radiotracer activity but increasing the acquisition times, especially in new digital PET scanner; using long-axial field of view (LAFOV) PET/CT tomographs; and modulating CT radiation dose by using artificial intelligence tools. All these approaches are in line with those implemented in our departments. Furthermore, the future trend is prioritizing data collection, in accordance with international guidelines, to better understand PET/CT dose discrepancies while also striving to optimize radiation doses without compromising the quality of PET images. Conclusions: several optimization methods have been developed and implemented to reduce the dose delivered to the patients who undergo PET/CT or PET/MRI examination; in recent years, the advent of digital PET and LAFOV scanners has been an important step in the evolution of molecular imaging and dose optimization and there has also been an increasingly widespread adoption in clinical practice.

Published
2024
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77. New Frontiers in Molecular Imaging with Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Efficacy, Toxicity, and Future Applications

Author

Frantellizzi, Viviana, Conte, Miriam, Pontico, Mariano, Pani, Arianna, Pani, Roberto, and De Vincentis, Giuseppe

Abstract

Supermagnetic Iron Oxide Nanoparticles (SPIONs) are nanoparticles that have an iron oxide core and a functionalized shell. SPIONs have recently raised much interest in the scientific community, given their exciting potential diagnostic and theragnostic applications. The possibility to modify their surface and the characteristics of their core make SPIONs a specific contrast agent for magnetic resonance imaging but also an intriguing family of tracer for nuclear medicine. An example is 68Ga-radiolabeled bombesin-conjugated to superparamagnetic nanoparticles coated with trimethyl chitosan that is selective for the gastrin-releasing peptide receptors. These receptors are expressed by several human cancer cells such as breast and prostate neoplasia. Since the coating does not interfere with the properties of the molecules bounded to the shell, it has been proposed to link SPIONs with antibodies. SPIONs can be used also to monitor the biodistribution of mesenchymal stromal cells and take place in various applications. The aim of this review of literature is to analyze the diagnostic aspect of SPIONs in magnetic resonance imaging and in nuclear medicine, with a particular focus on sentinel lymph node applications. Moreover, it is taken into account the possible toxicity and the effects on human physiology to determine the SPIONs’ safety.

Published
2024
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82. Head-to-Head Comparison between FDG and 11 C-Methionine in Multiple Myeloma: A Systematic Review.

Author

Filippi, Luca, Frantellizzi, Viviana, Bartoletti, Paola, Vincentis, Giuseppe De, Schillaci, Orazio, and Evangelista, Laura

Subjects
*MULTIPLE myeloma, *POSITRON emission tomography, *BONE marrow, *DIAGNOSTIC imaging
Abstract

The aim of this systematic review is to provide a comprehensive overview of the existing literature, comparing 18F-fluorodeoxyglucose (FDG) and 11C-methionine (MET) for the imaging of multiple myeloma (MM) with positron emission computed tomography (PET/CT). Relevant studies published from 2013 up to March 2023 were selected by searching Scopus, PubMed, and Web of Science. Selected imaging studies were analyzed using a modified version of the critical Appraisal Skills Programme (CASP). Ten studies encompassing 335 patients were selected. On a patient-based analysis, MET sensitivity ranged between 75.6% and 100%, resulting higher than that measured for FDG (0–100%). MET outperformed FDG for the detection of focal lesions, diffuse bone marrow involvement and mixed patterns. PET-derived parameters resulted higher for MET than for FDG, with a strong correlation with clinical variables (e.g., monoclonal component and beta-2-microglobulin levels, bone marrow infiltration, etc.), although FDG maintained a prognostic impact on outcome prediction. When compared to other tracers or imaging modalities, MET showed stronger correlation and inter-observer agreement than FDG. Although biased by the small cohorts and requiring confirmation through multicenter studies, preliminary findings suggest that MET–PET should be preferred to FDG for PET imaging of MM, or alternatively used as a complementary imaging modality. Some issues, such as tracer availability and the role of MET with respect to other emerging tracers (i.e., 68Ga-pentixafor, 18F-FACBC and 18F-FET), should be the topic of further investigations. [ABSTRACT FROM AUTHOR]

Published
2023
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84. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19

Author

Einstein, Andrew J., primary, Hirschfeld, Cole, additional, Williams, Michelle C., additional, Vitola, Joao V., additional, Better, Nathan, additional, Villines, Todd C., additional, Cerci, Rodrigo, additional, Shaw, Leslee J., additional, Choi, Andrew D., additional, Dorbala, Sharmila, additional, Karthikeyan, Ganesan, additional, Lu, Bin, additional, Sinitsyn, Valentin, additional, Ansheles, Alexey A., additional, Kudo, Takashi, additional, Bucciarelli-Ducci, Chiara, additional, Nørgaard, Bjarne Linde, additional, Maurovich-Horvat, Pál, additional, Campisi, Roxana, additional, Milan, Elisa, additional, Louw, Lizette, additional, Allam, Adel H., additional, Bhatia, Mona, additional, Sewanan, Lorenzo, additional, Malkovskiy, Eli, additional, Cohen, Yosef, additional, Randazzo, Michael, additional, Narula, Jagat, additional, Morozova, Olga, additional, Pascual, Thomas N.B., additional, Pynda, Yaroslav, additional, Dondi, Maurizio, additional, Paez, Diana, additional, Einstein, Andrew J., additional, Hinterleitner, Gerd, additional, Lu, Yao, additional, Xu, Zhuoran, additional, Hirschfeld, Cole B., additional, Erinne, Ikenna, additional, Shetty, Mrinali, additional, Choi, Andrew, additional, Lopez-Mattei, Juan, additional, Parwani, Purvi, additional, Goda, Artan, additional, Shirka, Ervina, additional, Bouyoucef, Salah, additional, Chelghoum, Lydia, additional, Mansouri, Farouk, additional, Medjahedi, Abdelkader, additional, Naili, Qais, additional, Ridouh, Mokhtar, additional, Alasia, Diego, additional, Alberghina, Lucia, additional, Aramayo, Natalia, additional, Buchara, Diego, additional, Busso, Franco Gabriel, additional, Bustos Rivadero, Jose Javier, additional, Camilletti, Jorge, additional, Campanelli, Hugo, additional, Castro, Ricardo Belisario, additional, Daicz, Mariana, additional, del Riego, Horacio, additional, Dragonetti, Laura, additional, Echazarreta, Diego, additional, Erriest, Juan, additional, Faccio, Fernando, additional, Facello, Adolfo, additional, Gallegos, Hugo, additional, Geronazzo, Ricardo, additional, Glait, Horacio, additional, Hasbani, Victor, additional, Jäger, Victor, additional, Lewkowicz, Julio Manuel, additional, Lotti, Jose, additional, Maciel, Neiva, additional, Masoli, Osvaldo, additional, Mastrovito, Edgardo, additional, Medus, Maria, additional, Merani, Maria Fernanda, additional, Molteni, Susana, additional, Montecinos, Marcos, additional, Parisi, Gustavo, additional, Sueldo, Claudio Pereyra, additional, Perez de Arenaza, Diego, additional, Quintana, Luis, additional, Radzinschi, Alejandro, additional, Redruello, Marcela, additional, Rodríguez, Marina, additional, Rojas, Horacio, additional, Acuña, Arturo Romero, additional, Schere, Daniel, additional, Traverso, Sonia, additional, Vazquez, Gustavo, additional, Zeffiro, Susana, additional, Sakanyan, Mari, additional, Beuzeville, Scott, additional, Boktor, Raef, additional, Crowley, Michael, additional, Downie, D'Arne, additional, Dwivedi, Girish, additional, Elison, Barry, additional, Farouque, Omar, additional, Jasper, Kim, additional, Joshi, Subodh, additional, Lee, Joseph, additional, Lee, Kenneth, additional, Lui, Elaine, additional, Mcconachie, Peter, additional, Meaker, Joanne, additional, Nandurkar, Dee, additional, Neill, Johanne, additional, O'Rourke, Edward, additional, O'Sullivan, Patricia, additional, Pandos, George, additional, Premaratne, Manuja, additional, Prior, David, additional, Rutherford, Natalie, additional, Saunders, Connor, additional, Taubman, Kim, additional, Tauro, Andrew, additional, Taylor, Andrew, additional, Theuerle, James, additional, Thomas, Paul, additional, Tow, Jonathan, additional, Upton, Anthony, additional, Vamadevan, Shankar, additional, Wayne, Victor, additional, Wegner, Eva Alina, additional, Wong, David, additional, Younger, John, additional, Beitzke, Dietrich, additional, Feuchtner, Gudrun, additional, Sommer, Oliver, additional, Weiss, Konrad, additional, Maroz-Vadalazhskaya, Natallia, additional, Tserakhau, Uladzimir, additional, Homans, Filip, additional, Van De Heyning, Caroline M., additional, Araujo, Raúl, additional, Soldat-Stankovic, Valentina, additional, Stankovic, Sinisa, additional, Almeida, Augusto, additional, Anselmi, Carlos, additional, Azevedo, Guilherme S.A., additional, Bittencourt, Marcio Sommer, additional, Pianta, Diego Bromfman, additional, Cabeda, Estevan, additional, Carreira, Lara, additional, Coelho, Igor, additional, de Amorim Fernandes, Fernando, additional, de Lorenzo, Andrea, additional, Delgado, Roberta, additional, Erthal, Fernanda, additional, Fernandes, Fabio, additional, Fernandes, Juliano, additional, Ferreira de Souza, Thiago, additional, Foppa, Murilo, additional, Matos Alves, Wilson Furlan, additional, Gontijo, Cibele, additional, Gottlieb, Ilan, additional, Grossman, Gabriel, additional, Albernaz Siqueira, Maria Helena, additional, Nomura, Cesar Higa, additional, Koga, Katia Hiromoto, additional, Lima, Ronaldo, additional, Lopes, Rafael, additional, Marçal Filho, Hugo Humberto, additional, Masiero, Paulo, additional, Mastrocola, Luiz, additional, Menezes de Siqueira, Maria Eduarda, additional, Mesquita, Claudio, additional, Naves, Danilo, additional, Penna, Filipe, additional, Pinto, Ibraim, additional, Rocha, Thércio, additional, Rocha, Juliana Leal, additional, Rodrigues, Alfredo, additional, Salioni, Leila, additional, Sanches, Adelina, additional, Santos, Marcelo, additional, Da Silva, Leonardo Sara, additional, Schvartzman, Paulo, additional, Matushita, Cristina Sebastião, additional, Senra, Tiago, additional, Silva, Marcelo, additional, Soares, Carlos Eduardo, additional, Spiro, Bernardo, additional, Suaide Silva, Carlos Eduardo, additional, Torres, Rafael, additional, Monte, Guilherme Urpia, additional, Vilela, Andrea, additional, Villa, Alexandre Volney, additional, Vitola, Joao, additional, Voss, Themissa, additional, Waltrick, Roberto, additional, Zapparoli, Marcello, additional, Naseer, Hamid, additional, Garcheva-Tsacheva, Marina, additional, Ouattara, Tiémégna Florence, additional, Thou, Sarameth, additional, Varoeun, Soley, additional, Abikhzer, Gad, additional, Beanlands, Rob, additional, Chetrit, Michael, additional, Dabreo, Dominique, additional, Dennie, Carole, additional, Friedrich, Matthias, additional, Hafez, Mohmmed Nassoh, additional, Hanneman, Kate, additional, Miller, Robert, additional, Oikonomou, Anastasia, additional, Roifman, Idan, additional, Small, Gary, additional, Tandon, Vikas, additional, Trivedi, Adwait, additional, White, James, additional, Zukotynski, Katherine, additional, Alay, Rita, additional, Concha, Carmen, additional, Massardo, Teresa, additional, Abad, Pedro, additional, Anzola, Kelly, additional, Arturo, Harold, additional, Benitez, Luis, additional, Cadena, Alberto, additional, Zamudio, Carlos Caicedo, additional, Calderón, Antonio, additional, Gutierrez Villamil, Claudia T., additional, Jaimes, Claudia, additional, Londono, Juan L., additional, Lopez, Nelson, additional, Merlano-Gaitan, Sonia, additional, Murgieitio-Cabrera, Ramon, additional, Valencia, Manuel, additional, Vergel, Damiana, additional, Santamaria, Alejandro Zuluaga, additional, Solis, Felix, additional, Batinic, Tonci, additional, Franceschi, Maja, additional, Paar, Maja Hrabak, additional, Prpic, Marina, additional, Felipe Batista, Cuba: Juan, additional, Cabrera, Lazaro Omar, additional, Peix, Amalia, additional, Peña, Yamilé, additional, Rochela Vázquez, Luis Manuel, additional, Ntalas, Ioannis, additional, Kaminek, Milan, additional, Kincl, Vladimir, additional, Lang, Otto, additional, Abdulla, Jawdat, additional, Bøttcher, Morten, additional, Busk, Martin, additional, Geisler, Uka, additional, Gormsen, Lars C., additional, Hansson, Nicolaj, additional, Hess, Søren, additional, Hove, Jens, additional, Jensen, Lars Thorbjoern, additional, Jensen, Magnus T., additional, Kragholm, Kristian Hay, additional, Nørgaard, Bjarne L., additional, Øvrehus, Kristian, additional, Rasmussen, Jan, additional, Rønnow Sand, Niels Peter, additional, Sondergaard, Hanne, additional, Zaremba, Tomas, additional, Speckter, Herwin, additional, Amores, Nelson, additional, Velez, Mayra Sanchez, additional, Alrahman, Taghreed Abd, additional, Elsamad, Sherif Abd, additional, Abdelfattah, Alia, additional, Allam, Adel, additional, Elkaffas, Sameh, additional, Hassan, Mona, additional, Hussein, Elshaymaa, additional, Ibrahim, Ahmed, additional, Kandeel, Ahmed, additional, Ali, Mohamed Mandour, additional, Shaaban, Mahmoud, additional, Flores, Camila, additional, Gómez Leiva, Verónica Vanesa, additional, Liiver, Anita, additional, Larikka, Martti, additional, Uusitalo, Valtteri, additional, Agostini, Denis, additional, Berger, Clothilde, additional, Dietz, Matthieu, additional, Hyafil, Fabien, additional, Ohana, Mickaël, additional, Prigent, Kevin, additional, Regaieg, Hamza, additional, Sarda-Mantel, Laure, additional, H-Ici, Darach O., additional, Ayetey, Harold, additional, Angelidis, George, additional, Fragkaki, Christina, additional, Fragkiadaki, Chrysoula, additional, Georgoulias, Panagiotis, additional, Koutelou, Maria, additional, Kyrozi, Elena, additional, Lama, Niki, additional, Prassopoulos, Vassilis, additional, Spartalis, Michael, additional, Zaglavara, Theodora, additional, Gonzalez, Carla, additional, Gutierrez, Goleat, additional, Maldonado, Alejandro, additional, Martinez, Yassine, additional, Kovács, Attila, additional, Szilveszter, Bálint, additional, Banthia, Nilesh, additional, Bhat, Vivek, additional, Choudhury, Partha, additional, Chowdekar, Vijay Sai, additional, Christopher, Johann, additional, Garg, Tushar, additional, Goyal, Naresh Kumar, additional, Gupta, Ripen Kumar, additional, Gupta, Abhishek, additional, Hephzibah, Julie, additional, Jain, Shashank, additional, Krupa, Jesu, additional, Kumar, Parveen, additional, Kumar, Sukriti, additional, Lalchandani, Arati, additional, Mishra, Animesh, additional, Mishra, Vivaswan Dutt, additional, Mohan, Parul, additional, Ozair, Ahmad, additional, Pandey, Shivani, additional, Parameswaran, Ramanathapuram, additional, Patel, Chetan, additional, Patel, Tapan, additional, Patel, Shivani, additional, Vimala, Leena Robinson, additional, Kumar Sarangi, Dr Pradosh, additional, Sengupta, Shantanu, additional, Sethi, Arvind, additional, Sharma, Amit, additional, Sharma, Awadhesh Kumar, additional, Sharma, Punit, additional, Shrigiriwar, Apurva, additional, Singh, Santosh, additional, Singh, Harpreet, additional, Sood, Ashwani, additional, Verma, Atul, additional, Vyas, Ajay, additional, Soeriadi, Erwin Affandi, additional, Bun, Edison, additional, Hutomo, Febby, additional, Syawaluddin, Hilman, additional, Yudistiro, Ryan, additional, Albadr, Amjed, additional, Assadi, Majid, additional, Emami, Farshad, additional, Emami-Ardekani, Alireza, additional, Farzanehfar, Saeed, additional, Jafari, Ramezan, additional, Manafi-Farid, Reyhaneh, additional, Tajik, Maryam, additional, Arnson, Yoav, additional, Fuchs, Shmuel, additional, Goldkorn, Ronen, additional, Kennedy, John, additional, Leitman, Marina, additional, Shalev, Aryeh, additional, Acampa, Wanda, additional, Albano, Domenico, additional, Alongi, Pierpaolo, additional, Arnone, Gaspare, additional, Assante, Roberta, additional, Baritussio, Anna, additional, Bauckneht, Matteo, additional, Bianco, Francesco, additional, Bonfiglioli, Rachele, additional, Bovenzi, Francesco, additional, Bruno, Isabella, additional, Bruno, Andrea, additional, Busnardo, Elena, additional, Califaretti, Elena, additional, Casoni, Roberta, additional, Censullo, Vittorio, additional, Chierichetti, Franca, additional, Chiocchi, Marcello, additional, Cittanti, Corrado, additional, Clemente, Alberto, additional, Cuocolo, Alberto, additional, De Rimini, Maria Luisa, additional, De Vincentis, Giuseppe, additional, Della Tommasina, Veronica, additional, Dellegrottaglie, Santo, additional, Erba, Paola Anna, additional, Evangelista, Laura, additional, Faggi, Lara, additional, Faragasso, Evelina, additional, Florimonte, Luigia, additional, Frantellizzi, Viviana, additional, Gatti, Marco, additional, Gaudiano, Angela, additional, Gelardi, Fabrizia, additional, Gerali, Alberto, additional, Gimelli, Alessia, additional, Guglielmo, Marco, additional, Leccisotti, Lucia, additional, Liga, Riccardo, additional, Liguori, Carlo, additional, Longo, Giampiero, additional, Maffione, Margherita, additional, Marcassa, Claudio, additional, Matassa, Giovanni, additional, Mele, Donato, additional, Mircoli, Luca, additional, Paccagnella, Andrea, additional, Pacella, Sara, additional, Padovano, Federica, additional, Pellegrini, Dario, additional, Pergola, Valeria, additional, Pugliese, Luca, additional, Quartuccio, Natale, additional, Rampin, Lucia, additional, Ricci, Fabrizio, additional, Rubini, Giuseppe, additional, Russo, Vincenzo, additional, Sambuceti, Gianmario, additional, Scatteia, Alessandra, additional, Sciagrà, Roberto, additional, Spidalieri, Gianluca, additional, Stefanelli, Antonella, additional, Tedeschi, Carlo, additional, Ventroni, Guido, additional, Baugh, Dainia, additional, Madu, Ernest, additional, Aikawa, Tadao, additional, Asano, Hiroshi, additional, Fujimoto, Shinichiro, additional, Fujise, Koichiro, additional, Fukushima, Yoshimitsu, additional, Fukuyama, Kae, additional, Ichikawa, Yasutaka, additional, Ideguchi, Reiko, additional, Iguchi, Nobuo, additional, Imai, Masamichi, additional, Ishimura, Hayato, additional, Isobe, Satoshi, additional, Ito, Kimiteru, additional, Izawa, Yu, additional, Kadokami, Toshiaki, additional, Kasai, Tokuo, additional, Kato, Takao, additional, Kawamoto, Takashi, additional, Kiryu, Shigeru, additional, Kumita, Shinichiro, additional, Manabe, Osamu, additional, Maruno, Hirotaka, additional, Matsumoto, Naoya, additional, Miyagawa, Masao, additional, Moroi, Masao, additional, Nagamachi, Shigeki, additional, Nakajima, Kenichi, additional, Nakazato, Ryo, additional, Nanasato, Mamoru, additional, Naya, Masanao, additional, Norikane, Takashi, additional, Ohta, Yasutoshi, additional, Otomi, Yoichi, additional, Otsuka, Hideki, additional, Oyama-Manabe, Noriko, additional, Saito, Masaki, additional, Sarai, Masayoshi, additional, Sato, Junichi, additional, Sato, Daisuke, additional, Shiraishi, Shinya, additional, Takanami, Kentaro, additional, Takehana, Kazuya, additional, Taniguchi, Yasuyo, additional, Teragawa, Hiroki, additional, Tomizawa, Nobuo, additional, Umeji, Kyoko, additional, Wakabayashi, Yasushi, additional, Yamada, Shinichiro, additional, Yamazaki, Shinya, additional, Yoneyama, Tatsuya, additional, Rawashdeh, Mohammad, additional, Dautov, Tairkhan, additional, Makhdomi, Khalid, additional, Abass, Mostafa, additional, Garashi, Masoud, additional, Siraj, Qaisar, additional, Kalnina, Marika, additional, Haidar, Mohamad, additional, Komiagiene, Renata, additional, Kviecinskiene, Giedre, additional, Vajauskas, Donatas, additional, Karim, Noor Khairiah A., additional, Doucoure, Mady, additional, Reichmuth, Luise, additional, Samuel, Anthony, additional, Dieng, Mohamed Lemine, additional, Naojee, Ambedhkar Shantaram, additional, Hernandez, Estrella Aguilera, additional, Alducin Tellez, Cesar Rene, additional, Alexánderson-Rosas, Erick, additional, Barragan, Erika, additional, Cabada, Manuel, additional, Calderón, Daniel, additional, Carvajal-Juarez, Isabel, additional, Esparza, José, additional, Gama-Moreno, Manlio Gerardo, additional, Quinto, Virginia Garcia, additional, Gonzalez, Nelsy Coromoto, additional, Herrera-Zarza, Mary Carmen, additional, Meave, Aloha, additional, Medina Verdugo, Jesus Gregorio, additional, Melendez, Gabriela, additional, Morales Murguia, Rafael Humberto, additional, Navarro Quiroz, Carlos Salvador, additional, Ornelas, Mario, additional, Preciado-Anaya, Andres, additional, Preciado-Gutiérrez, Oscar Ulises, additional, Puente, Adriana, additional, Salazar, Aristóteles Ramírez, additional, Rosales Uvera, Sandra Graciela, additional, Rosales-Uvera, Sandra, additional, Serna Macias, Jose Antonio, additional, Sierra-Galan, Lilia, additional, Sierra-Galan, Lilia M., additional, Tirado Alderete, Juan Carlos, additional, Vallejo, Enrique, additional, Faraggi, Marc, additional, Sereegotov, Erdenechimeg, additional, Ben Rais, Nouzha, additional, Alaoui, Nadia Ismaili, additional, Kyiphyu, Thiri, additional, Oo, Su Thet, additional, Win, Soe Myat, additional, Zar, Htin, additional, Ghimire, Ram, additional, Neupane, Madhu, additional, Glaudemans, Andor, additional, Slart, Riemer, additional, Verschure, Derk, additional, Allen, Berry, additional, Edmond, John, additional, Mckenzie, Clare, additional, Tie, Stuart, additional, Van Pelt, Niels, additional, Worthington, Kirsten, additional, Young, Calum, additional, Soli, Idrissa Adamou, additional, Kana, Shehu, additional, Onubogu, Uchenna, additional, Sani, Mahmoud, additional, Bråten, Anders Tjellaug, additional, Jørgensen, Arve, additional, Vassbotn, Hanne-Elin, additional, Al Dhuhli, Humoud, additional, Jawa, Zabah, additional, Tag, Naima, additional, Fatima, Shazia, additional, Imran, Muhammad Babar, additional, Younis, Muhammad Numair, additional, Saadullah, Mohammad, additional, Malo, Yariela Herrera, additional, Lenturut-Katal, Dora, additional, Castillo, Manuel, additional, Ortellado, José, additional, Akhter, Afroza, additional, Cader, F. Aaysha, additional, Hussain, Raihan, additional, Khan, Saidur Rahman, additional, Mandal, Tapati, additional, Nasreen, Faria, additional, An, Yunqiang, additional, Cao, Dianbo, additional, Gong, Lianggeng, additional, Hou, Yang, additional, Jia, Chongfu, additional, Li, Tao, additional, Li, Caiying, additional, Liu, Hui, additional, Liu, Wenya, additional, Liu, Jinkang, additional, Ng, Ming-Yen, additional, Shi, Heshui, additional, Tang, Chunxiang, additional, Wang, Ximing, additional, Wang, Zhaoqian, additional, Wang, Yining, additional, Wu, Jiang, additional, Yi, Yan, additional, Yuan, Li, additional, Zhang, Tong, additional, Zhang, Longjiang, additional, Chavez, Edith, additional, Cruz, Carlos, additional, Llontop, Christian, additional, Morales, Rosanna, additional, Abrihan, Paz, additional, Bustos-Barroso, Asela, additional, Duldulao-Ogbac, Michele, additional, Eduarte, Christopher, additional, Obaldo, Jerry, additional, Quinon, Alvin, additional, San Juan, Belinda, additional, San Juan, Carlo Joe, additional, Sauler-Gomez, Marie Rhiamar, additional, Uy, Mila, additional, Kostkiewicz, Magdalena, additional, Kunikowska, Jolanta, additional, Teresinska, Anna, additional, Urbanik, Tomasz, additional, Bettencourt, Nuno, additional, Fontes-Carvalho, Ricardo, additional, Gavina, Cristina, additional, Gonçalves, Lino, additional, Macedo, Filipe, additional, Moreno, Nuno, additional, Sousa, Carla, additional, Timoteo, Ana Teresa, additional, Vidigal, Maria João, additional, Al Heidous, Mahmoud, additional, Ramanathan, Subramaniyan, additional, Arnous, Samer, additional, Aytani, Said, additional, Byrne, Angela, additional, Gleeson, Tadhg, additional, Kerins, David, additional, O'Brien, Julie, additional, Bang, Ji-In, additional, Bom, Henry, additional, Cheon, Miju, additional, Cheon, Gi Jeong, additional, Cho, Sang-Geon, additional, Hong, Chae Moon, additional, Jeong, Yong Hyu, additional, Kang, Won Jun, additional, Kang, Yeon-Koo, additional, Kim, Ji-Young, additional, Oh, So Won, additional, So, Young, additional, Song, Ho-Chun, additional, Won, Kyoung Sook, additional, Yoo, Soo Woong, additional, Mitevska, Irena, additional, Vavlukis, Marija, additional, Salobir, Barbara Gužic, additional, Štalc, Monika, additional, Benedek, Theodora, additional, Pop, Marian, additional, Stan, Claudiu, additional, Ansheles, Alexey, additional, Dariy, Olga, additional, Gagarina, Nina, additional, Itskovich, Irina, additional, Karalkin, Anatoliy, additional, Kokov, Alexander, additional, Marina, Gulya, additional, Migunova, Ekaterina, additional, Pospelov, Viktor, additional, Ryzhkova, Daria, additional, Sayfullina, Guzaliya, additional, Sergienko, Vladimir, additional, Shurupova, Irina, additional, Vakhromeeva, Margarita, additional, Valiullina, Nailia, additional, Zavadovsky, Konstantin, additional, Zhuravlev, Kirill, additional, Abazid, Rami, additional, Al Garni, Turki, additional, Alasnag, Mirvat, additional, Aljizeeri, Ahmed, additional, Amer, Hamid, additional, Amro, Ahmad, additional, Hamdy, Hesham, additional, Smettei, Osama, additional, Saranovic, Dragana Sobic, additional, Vlajkovic, Marina, additional, Keng, Felix, additional, See, Jason, additional, Berecova, Zuzana, additional, Mistinova, Jana Polakova, additional, Evbuomwan, Osayande, additional, Govender, Nerisha, additional, Hack, Jonathan, additional, Hadebe, Bawinile, additional, Hlongwa, Khanyisile, additional, Kaplan, Mitchell, additional, Lakhi, Hoosen, additional, Milos, Katarina, additional, Modiselle, Moshe, additional, More, Stuart, additional, Muambadzi, Ntanganedzeni, additional, Scholtz, Leonie, additional, Barreiro-Perez, Manuel, additional, Blanco, Isabel, additional, Broncano, Jordi, additional, Camarero, Alicia, additional, Casáns-Tormo, Irene, additional, De Haro, Javier, additional, Flotats, Albert, additional, García, Elia, additional, Mendiguchia, Ceferino Gutierrez, additional, Jimenez-Heffernan, Amelia, additional, Leta, Ruben, additional, Diaz, Javier Lopez, additional, Vega, Luis Lumbreras, additional, Manovel-Sánchez, Ana, additional, Monzonis, Amparo Martinez, additional, Patrut, Bianca, additional, Pubul, Virginia, additional, Perez, Ricardo Ruano, additional, Zeidan, Nahla, additional, Nanayakkara, Damayanthi, additional, Suliman, Ahmed, additional, Engblom, Henrik, additional, Murtadha, Mustafa, additional, Ostenfeld, Ellen, additional, Simonsson, Magnus, additional, Alkadhi, Hatem, additional, Buechel, Ronny Ralf, additional, Burger, Peter, additional, Gräni, Christoph, additional, Kamani, Christel, additional, Kawel-Böhm, Nadine, additional, Klaeser, Bernd, additional, Manka, Robert, additional, Prior, John, additional, Kaewchur, Tawika, additional, Khiewvan, Benjapa, additional, Kositwattanarerk, Arpakorn, additional, Namwongprom, Sirianong, additional, Thientunyakit, Tanyaluck, additional, Sayman, Haluk Burcak, additional, Yüksel, Mahmut, additional, Sebikali, Mugisha Julius, additional, Okello, Emmy, additional, Korol, Pavlo, additional, Noverko, Iryna, additional, Satyr, Maryna, additional, Ahmad, Tahir, additional, Alfakih, Khaled, additional, Andrade, Ivo, additional, Buckingham, Susan, additional, Bularga, Anda, additional, Carpenter, John-Paul, additional, Cole, Graham, additional, Cusack, David, additional, David, Sarojini, additional, Davis, Patrick, additional, Fairbairn, Timothy, additional, Ghosh, Arjun, additional, Ramkumar, Prasad Guntur, additional, Hamilton, Mark, additional, Haque, Faisal, additional, Hudson, Benjamin, additional, Johnstone, Annette, additional, Karthikeyan, V.J., additional, Kay, Mike, additional, Khan, Mohammad Ali, additional, Kitt, Jamie, additional, Low, Chen Sheng, additional, Mcalindon, Elisa, additional, Mccreavy, David, additional, Morrissey, Brian, additional, Motwani, Manish, additional, Na, Dilip, additional, Nicol, Edward, additional, Patel, Dilip, additional, Rodrigues, Jonathan, additional, Rofe, Chris, additional, Schofield, Rebecca, additional, Semple, Thomas, additional, Sheikh, Azeem, additional, Sinha, Apurva, additional, Subedi, Deepak, additional, Topping, William, additional, Tweed, Katherine, additional, Underwood, Stephen Richard, additional, Weir-Mccall, Jonathan, additional, Zuhairy, Hamed, additional, Abbasi, Taimur, additional, Abohashem, Shady, additional, Abramson, Sandra, additional, Al-Mallah, Mouaz, additional, Kumar, Mohan Ashok, additional, Balmer-Swain, Mallory, additional, Berman, Daniel, additional, Bernheim, Adam, additional, Bhatti, Sabha, additional, Biederman, Robert, additional, Bieging, Erik, additional, Bingham, Scott, additional, Bloom, Stephen, additional, Blue, Sean, additional, Borges, Andressa, additional, Branch, Kelley, additional, Bravo, Paco, additional, Buddhe, Sujatha, additional, Budoff, Matthew, additional, Bullock-Palmer, Renée, additional, Cahill, Michael, additional, Candela, Candace, additional, Cao, Jane, additional, Chatterjee, Saurav, additional, Chatzizisis, Yiannis, additional, Chaudhuri, Nita Ray, additional, Cheezum, Michael, additional, Chelliah, Anjali, additional, Chen, Tiffany, additional, Chen, Marcus, additional, Chen, Lu, additional, Chokshi, Aalap, additional, Chung, Jina, additional, Danciu, Sorin, additional, DeSisto, William, additional, Dilorenzo, Michael, additional, Doukky, Rami, additional, Duvall, William, additional, Ferencik, Maros, additional, Foster, Cameron, additional, Fuisz, Anthon, additional, Gannon, Michael, additional, German, David, additional, Gerson, Myron, additional, Geske, Jeffrey, additional, Hage, Fadi, additional, Haider, Agha, additional, Haider, Sofia, additional, Hamirani, Yasmin, additional, Hassen, Karen, additional, Hendel, Robert, additional, Henkel, Jacqueline, additional, Horgan, Stephen, additional, Hyun, Mark, additional, Janardhanan, Rajesh, additional, Jerome, Scott, additional, Kalra, Dinesh, additional, Kassop, David, additional, Kinkhabwala, Mona, additional, Kinzfogl, George, additional, Koch, Bernard, additional, Koweek, Lynne, additional, Krepp, Joseph, additional, Kwon, Younghoon, additional, Layer, Jay, additional, Lesser, John, additional, Leung, Steve, additional, Lisske, Bernadette, additional, Magurany, Kathleen, additional, Markowitz, Jeremy, additional, Mccullough, Brenda, additional, Moalemi, Azita, additional, Moffitt, Chanan, additional, Montanez, Juan, additional, Moore, Warren, additional, Morayati, Shamil, additional, Mossa-Basha, Mahmud, additional, Mrsic, Zorana, additional, Murthy, Venkatesh, additional, Nagpal, Prashant, additional, Nelson, Katarina, additional, Nijjar, Prabhjot, additional, O’Quinn, Rupal, additional, Passen, Edward, additional, Patel, Toral, additional, Patil, Pravin, additional, Pursnani, Amit, additional, Quachang, Nancy, additional, Rabbat, Mark, additional, Ranjan, Pragya, additional, Lozano, Patricia Rodriguez, additional, Schemmer, Mary, additional, Seifried, Rebecca, additional, Shah, Nishant, additional, Shah, Amee, additional, Shanbhag, Sujata, additional, Sharma, Gaurav, additional, Skotnicki, Robert, additional, Sobczak, Michael, additional, Soman, Prem, additional, Sorrell, Vincent, additional, Srichai, Monvadi, additional, Streeter, Jim, additional, Strickland, Leah, additional, Suliman, Suliman, additional, Tebyanian, Naghmeh, additional, Thomas, Dustin, additional, Thompson, Randall, additional, Uretsky, Seth, additional, Vallurupalli, Srikanth, additional, Vandyck-Acquah, Marian, additional, Verma, Vikas, additional, Villines, Todd, additional, Weinstein, Joseph, additional, Wolinsky, David, additional, Zareba, Karolina, additional, Zgaljardic, Michael, additional, Beretta, Mario, additional, Ferrando, Rodolfo, additional, Kapitan, Miguel, additional, Mut, Fernando, additional, Djuraev, Omoa, additional, Rozikhodjaeva, Gulnora, additional, Vera, Luisa, additional, Duc, Binh Duong, additional, Nguyen, Xuan Canh, additional, and Hiep Nguyen, Phuoc Minh, additional

Published
2022
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85. Prognostic Value of the BIO-Ra Score in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Radium-223 after the European Medicines Agency Restricted Use: Secondary Investigations of the Multicentric BIO-Ra Study

Author

Bauckneht, Matteo, primary, Rebuzzi, Sara Elena, additional, Ponzano, Marta, additional, Borea, Roberto, additional, Signori, Alessio, additional, Frantellizzi, Viviana, additional, Lodi Rizzini, Elisa, additional, Mascia, Manlio, additional, Lavelli, Valentina, additional, Miceli, Alberto, additional, De Feo, Maria Silvia, additional, Pisani, Antonio Rosario, additional, Nuvoli, Susanna, additional, Tripoli, Vincenzo, additional, Morganti, Alessio Giuseppe, additional, Mammucci, Paolo, additional, Caponnetto, Salvatore, additional, Mantica, Guglielmo, additional, Di Nicola, Angelo Domenico, additional, Villano, Carlo, additional, Cindolo, Luca, additional, Morbelli, Silvia, additional, Sambuceti, Gianmario, additional, Fanti, Stefano, additional, Costa, Renato Patrizio, additional, Spanu, Angela, additional, Rubini, Giuseppe, additional, Monari, Fabio, additional, De Vincentis, Giuseppe, additional, and Fornarini, Giuseppe, additional

Published
2022
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86. Radium-223 in mCPRC patients: a large real-life Italian multicenter study

Author

FRANTELLIZZI, Viviana, primary, MONARI, Fabio, additional, MASCIA, Manlio, additional, COSTA, Renato P., additional, RUBINI, Giuseppe, additional, SPANU, Angela, additional, FARCOMENI, Alessio, additional, LODI RIZZINI, Elisa, additional, CINDOLO, Luca, additional, TRIPOLI, Vincenzo, additional, LAVELLI, Valentina, additional, NUVOLI, Susanna, additional, PONTICO, Mariano, additional, DIONISI, Valeria, additional, FERRARI, Cristina, additional, and DE VINCENTIS, Giuseppe, additional

Published
2022
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87. The impact of COVID-19 on diagnosis of heart disease in Latin America an INCAPS COVID sub-analysis

Author

Rodrigo Julio Cerci, Jo??o Vicente Vitola, Diana, Paez, Alejandro, Zuluaga, Marcio Sommer Bittencourt, Sierra-Galan, Lilia M., Patricia, Carrascosa, Roxana, Campisi, Claudia, Gutierrez-Villamil, Amalia, Peix, Duane, Chambers, Mayra S??nches Velez, Alvarado, Carla M. G., Ventura, Ana C. F., Alejandro, Maldonado, Castanos, Alfredo P., Diaz, Teresa C., Yariela, Herrera, Vasquez, Manuel C., Arrieta, Ana A., Fernando, Mut, Cole, Hirschfeld, Eli, Malkovskiy, Benjamin, Goebel, Yosef, Cohen, Michael, Randazzo, Shaw, Leslee J., Williams, Michelle C., Villines, Todd C., Nathan, Better, Sharmila, Dorbala, Paolo, Raggi, Pascual, Thomas N. B., Yaroslav, Pynda, Maurizio, Dondi, Frantellizzi, Viviana, DE VINCENTIS, Giuseppe, and Einstein, Andrew J.

Subjects
Coronavírus, cardiac testing, COVID-19, cardiovascular disease, global health
Published
2022

88. Qualitative and Semiquantitative Parameters of 18 F-FDG-PET/CT as Predictors of Malignancy in Patients with Solitary Pulmonary Nodule.

Author

Corica, Ferdinando, De Feo, Maria Silvia, Stazza, Maria Lina, Rondini, Maria, Marongiu, Andrea, Frantellizzi, Viviana, Nuvoli, Susanna, Farcomeni, Alessio, De Vincentis, Giuseppe, and Spanu, Angela

Subjects
TUMOR prevention, TUMOR risk factors, SOLITARY pulmonary nodule, RESEARCH evaluation, RETROSPECTIVE studies, LUNG tumors, CANCER patients, QUALITATIVE research, RADIOPHARMACEUTICALS, POSITRON emission tomography, DESCRIPTIVE statistics, DEOXY sugars, COMPUTED tomography, PROBABILITY theory
Abstract

Simple Summary: This study aims to evaluate the reliability of qualitative and semiquantitative parameters of 18F-FDG PET-CT, and eventually a correlation between them, in predicting the risk of malignancy in patients with solitary pulmonary nodule (SPN) before the diagnosis of lung cancer. Qualitative and semiquantitative parameters can be considered reliable tools in patients with SPN, since cut-offs for SUVmax, SUVmean, TLG and MTV showed good sensitivity and specificity in predicting malignancy. This study aims to evaluate the reliability of qualitative and semiquantitative parameters of 18F-FDG PET-CT, and eventually a correlation between them, in predicting the risk of malignancy in patients with solitary pulmonary nodules (SPNs) before the diagnosis of lung cancer. A total of 146 patients were retrospectively studied according to their pre-test probability of malignancy (all patients were intermediate risk), based on radiological features and risk factors, and qualitative and semiquantitative parameters, such as SUVmax, SUVmean, TLG, and MTV, which were obtained from the FDG PET-CT scan of such patients before diagnosis. It has been observed that visual analysis correlates well with the risk of malignancy in patients with SPN; indeed, only 20% of SPNs in which FDG uptake was low or absent were found to be malignant at the cytopathological examination, while 45.45% of SPNs in which FDG uptake was moderate and 90.24% in which FDG uptake was intense were found to be malignant. The same trend was observed evaluating semiquantitative parameters, since increasing values of SUVmax, SUVmean, TLG, and MTV were observed in patients whose cytopathological examination of SPN showed the presence of lung cancer. In particular, in patients whose SPN was neoplastic, we observed a median (MAD) SUVmax of 7.89 (±2.24), median (MAD) SUVmean of 3.76 (±2.59), median (MAD) TLG of 16.36 (±15.87), and a median (MAD) MTV of 3.39 (±2.86). In contrast, in patients whose SPN was non-neoplastic, the SUVmax was 2.24 (±1.73), SUVmean 1.67 (±1.15), TLG 1.63 (±2.33), and MTV 1.20 (±1.20). Optimal cut-offs were drawn for semiquantitative parameters considered predictors of malignancy. Nodule size correlated significantly with FDG uptake intensity and with SUVmax. Finally, age and nodule size proved significant predictors of malignancy. In conclusion, considering the pre-test probability of malignancy, qualitative and semiquantitative parameters can be considered reliable tools in patients with SPN, since cut-offs for SUVmax, SUVmean, TLG, and MTV showed good sensitivity and specificity in predicting malignancy. [ABSTRACT FROM AUTHOR]

Published
2023
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89. 18 F-fluorodeoxyglucose (18 F-FDG) Functionalized Gold Nanoparticles (GNPs) for Plasmonic Photothermal Ablation of Cancer: A Review.

Author

Pontico, Mariano, Conte, Miriam, Petronella, Francesca, Frantellizzi, Viviana, De Feo, Maria Silvia, Di Luzio, Dario, Pani, Roberto, De Vincentis, Giuseppe, and De Sio, Luciano

Subjects
GOLD nanoparticles, PLASMONICS, NEAR infrared radiation, PHOTOTHERMAL effect, MEDICAL research, ATRIAL flutter, NANOSTRUCTURES
Abstract

The meeting and merging between innovative nanotechnological systems, such as nanoparticles, and the persistent need to outperform diagnostic-therapeutic approaches to fighting cancer are revolutionizing the medical research scenario, leading us into the world of nanomedicine. Photothermal therapy (PTT) is a non-invasive thermo-ablative treatment in which cellular hyperthermia is generated through the interaction of near-infrared light with light-to-heat converter entities, such as gold nanoparticles (GNPs). GNPs have great potential to improve recovery time, cure complexity, and time spent on the treatment of specific types of cancer. The development of gold nanostructures for photothermal efficacy and target selectivity ensures effective and deep tissue-penetrating PTT with fewer worries about adverse effects from nonspecific distributions. Regardless of the thriving research recorded in the last decade regarding the multiple biomedical applications of nanoparticles and, in particular, their conjugation with drugs, few works have been completed regarding the possibility of combining GNPs with the cancer-targeted pharmaceutical fluorodeoxyglucose (FDG). This review aims to provide an actual scenario on the application of functionalized GNP-mediated PTT for cancer ablation purposes, regarding the opportunity given by the 18F-fluorodeoxyglucose (18F-FDG) functionalization. [ABSTRACT FROM AUTHOR]

Published
2023
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91. Early 18 F‐FDG PET/CT in COVID‐19

Author

Cosma, Laura, Sollaku, Saadi, Frantellizzi, Viviana, and De Vincentis, Giuseppe

Subjects
medicine.medical_specialty, Colorectal cancer, Disease, Asymptomatic, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, lymphadenopathy, Medicine, Radiology, Nuclear Medicine and imaging, Lung, infection lung, F-FDG PET/CT, COVID-19, SARS-CoV-2, business.industry, Cancer, medicine.disease, medicine.anatomical_structure, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Biomarker (medicine), Radiology, medicine.symptom, Lymphocytopenia, Abnormality, business
Abstract

We report the case of who has been hospitalized complaining about fever in the last 4 days. Laboratory data revealed lymphocytopenia and leucopenia with an elevation of C-reactive protein and positive real-time reverse transcription-polymerase chain reaction (RT-PCR). Six days before this hospitalization, when the patient was asymptomatic, 18 F-FDG PET/CT images were performed for the therapeutic control of liver metastases of colorectal cancer. Lung abnormality findings at 18 F-FDG PET/CT images, unrelated to cancer metastases, but suspicious for viral infection, may suggest the presence of COVID-19 disease in its early phase before symptoms onset. Since PET/CT is more sensitive than CT scan in detecting host's reaction, the added value of this technique could be monitoring disease progression and could be used as a biomarker of lung disease activity and therefore as an important tool for a better understanding of the factors that contribute to the progression of lung disease.

Published
2020
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93. DNA Damage Repair Defects and Targeted Radionuclide Therapies for Prostate Cancer: Does Mutation Really Matter? A Systematic Review.

Author

Filippi, Luca, Palumbo, Barbara, Bagni, Oreste, Frantellizzi, Viviana, De Vincentis, Giuseppe, and Schillaci, Orazio

Subjects
DNA repair, DNA damage, PROSTATE cancer, RADIOISOTOPES, PROGRESSION-free survival, RADIONUCLIDE imaging, CANCER treatment
Abstract

The aim of the present review was to assess the impact of DNA damage repair (DDR) mutations on response and outcome of patients (pts) affected by advanced prostate cancer (PCa) submitted to radionuclide therapies with [223Ra]RaCl2 (223Ra-therapy) or prostate specific membrane antigen (PSMA) ligands. A systematic literature search according to PRISMA criteria was made by using two main databases. Only studies published up until to October 2022 in the English language with ≥10 enrolled patients were selected. Seven studies including 326 pts, of whom 201 (61.6%) harboring DDR defects, were selected. The majority of selected papers were retrospective and four out of seven (57.1%) had small sample size (<50 pts). Three out of seven (42.8%) studies reported a more favorable outcome (overall or progression free survival) after therapy with alpha emitters (223Ra-therapy or [225Ac]Ac-PSMA-617) in subjects with DDR defects with respect to those without mutations. In two studies employing alpha or beta emitters ([177Lu]/[225Ac]-PMSA), no significant benefit was registered in pts harboring DDR defects. In all but one paper, no significant difference in response rate was reported among pts with or without DDR mutations. Although preliminary and biased by the retrospective design, preliminary data suggest a trend towards a longer survival in PCa pts harboring DDR defects submitted to radionuclide targeted therapy with alpha emitters. [ABSTRACT FROM AUTHOR]

Published
2023
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94. Usefulness of 99mTc-Pertechnetate SPECT-CT in Thyroid Tissue Volumetry: Phantom Studies and a Clinical Case Series

Author

Calandri, Enrico, Giraudo, Maria Teresa, Sirovich, Roberta, Ostan, Antonella, Pultrone, Mirco, Frantellizzi, Viviana, Conversano, Lucia, Bagnasacco, Paolo, Gallina, Sonya, and De Vincentis, Giuseppe

Subjects
Pharmacology, Tomography, Emission-Computed, Single-Photon, theragnostics, Hyperthyroidism, SPECT, SPECT-CT, hyperthyroidism, thyroid, thyroid tissue volumetry, Humans, Radiology, Nuclear Medicine and imaging, Radiopharmaceuticals, Tomography, X-Ray Computed, Sodium Pertechnetate Tc 99m
Abstract

Background: An accurate measurement of the target volume is of primary importance in theragnostics of hyperthyroidism. Objective: Our purpose was to evaluate the accuracy of a threshold-based isocontour extraction procedure for thyroid tissue volumetry from SPECT-CT. Methods: Cylindrical vials with a fixed volume of 99mTcO4 at different activities were inserted into a neck phantom in two different thickness settings. Images were acquired by orienting the phantom in different positions, i.e., 40 planar images and 40 SPECT-CT. The fixed values of the isocontouring threshold for SPECT and SPECT-CT were calculated by means of linear and spline regression models. Mean, Median, Standard Deviation, Standard Error, Mean Absolute Percentage Error and Root Mean-Square Error were computed. Any difference between the planar method, SPECT and SPECT-CT and the effective volume was evaluated by means of ANOVA and posthoc tests. Moreover, planar and SPECT-CT acquisitions were performed in 8 patients with hyperthyroidism, considering relevant percentage differences greater than > 20% from the CT gold standard. Results: Concerning phantom studies, the planar method shows higher values of each parameter than the other two methods. SPECT-CT shows lower variability. However, no significant differences were observed between SPECT and SPECT-CT measurements. In patients, relevant differences were found in 7 out of 9 lesions with the planar method, in 6 lesions with SPECT, but in only one with SPECT-CT. Conclution: Our study confirms the superiority of SPECT in volume measurement if compared with the planar method. A more accurate measurement can be obtained from SPECT-CT.

Published
2021

95. Prostate-specific membrane antigen-directed imaging and radioguided surgery with single-photon emission computed tomography: state of the art and future outlook.

Author

Filippi, Luca, Palumbo, Barbara, Frantellizzi, Viviana, Nuvoli, Susanna, De Vincentis, Giuseppe, Spanu, Angela, and Schillaci, Orazio

Subjects
SINGLE-photon emission computed tomography, POSITRON emission tomography, FIRE detectors, PROSTATE cancer patients, RADIOLABELING
Abstract

Prostate-specific membrane antigen (PSMA) has emerged as a highly relevant target for prostate cancer (PC) diagnosis and therapy. PSMA inhibitors targeting PSMA-enzymatic domain have been successfully labeled with radionuclides emitting positrons or gamma-photons, thus obtaining tracers suitable for imaging with positron emission computed tomography (PET/CT) or single-photon emission tomography (SPECT). The different approaches for obtaining PSMA-ligands labeled with gamma-emitting nuclides (99mTc or111In) are reviewed. Furthermore, the applications of 99mTc/111In-PSMA SPECT for the imaging of PC patients in different clinical settings (staging or biochemical recurrence) are covered. Lastly, the employment of PSMA-targeted SPECT tracers for radioguided surgery (RGS) during primary or salvage lymphadenectomy is discussed. RGS provided satisfying preliminary results in both primary and salvage lymphadenectomy, allowing to discriminate between pathological and non-pathological nodes with high accuracy, although prospective studies with larger cohorts are needed to further validate this surgical approach. The potential of PSMA-targeted SPECT/CT has not been fully explored yet, but it might represent a relatively cost-effective alternative to PSMA PET/CT in limited resource environments. In this perspective, the implementation of novel SPECT technologies or algorithms, such as semiconductor-ionization detectors or resolution recovery reconstruction, will be topic of future investigation. [ABSTRACT FROM AUTHOR]

Published
2022
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99. The prognostic power of inflammatory indices and clinical factors in metastatic castration-resistant prostate cancer patients treated with radium-223 (BIO-Ra study)

Author

Bauckneht, Matteo, primary, Rebuzzi, Sara Elena, additional, Signori, Alessio, additional, Frantellizzi, Viviana, additional, Murianni, Veronica, additional, Lodi Rizzini, Elisa, additional, Mascia, Manlio, additional, Lavelli, Valentina, additional, Donegani, Maria Isabella, additional, Ponzano, Marta, additional, Gaudiano, Angela, additional, Stazza, Maria Lina, additional, Licari, Maria, additional, Cavallini, Letizia, additional, Laghi, Viola, additional, Cindolo, Luca, additional, Maggi, Martina, additional, Sciarra, Alessandro, additional, Mammucci, Paolo, additional, Sambuceti, Gianmario, additional, Costa, Renato Patrizio, additional, Spanu, Angela, additional, Rubini, Giuseppe, additional, Monari, Fabio, additional, De Vincentis, Giuseppe, additional, and Fornarini, Giuseppe, additional

Published
2021
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