Search

Your search keyword '"Franke, Molly F"' showing total 496 results
Start Over Author "Franke, Molly F"
496 results on '"Franke, Molly F"'

55. Development and validation of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis

Author

Gunasekera, Kenneth S., primary, Marcy, Olivier, additional, Muñoz, Johanna, additional, Lopez-Varela, Elisa, additional, Sekadde, Moorine P., additional, Franke, Molly F., additional, Bonnet, Maryline, additional, Ahmed, Shakil, additional, Amanullah, Farhana, additional, Anwar, Aliya, additional, Augusto, Orvalho, additional, Aurilio, Rafaela Baroni, additional, Banu, Sayera, additional, Batool, Iraj, additional, Brands, Annemieke, additional, Cain, Kevin P., additional, Carratalá-Castro, Lucía, additional, Caws, Maxine, additional, Click, Eleanor S., additional, Cranmer, Lisa M., additional, García-Basteiro, Alberto L., additional, Hesseling, Anneke C., additional, Huynh, Julie, additional, Kabir, Senjuti, additional, Lecca, Leonid, additional, Mandalakas, Anna, additional, Mavhunga, Farai, additional, Myint, Aye Aye, additional, Myo, Kyaw, additional, Nampijja, Dorah, additional, Nicol, Mark P., additional, Orikiriza, Patrick, additional, Palmer, Megan, additional, Sant’Anna, Clemax Couto, additional, Siddiqui, Sara Ahmed, additional, Smith, Jonathan P., additional, Song, Rinn, additional, Thuong Thuong, Nguyen Thuy, additional, Ung, Vibol, additional, van der Zalm, Marieke M., additional, Verkuijl, Sabine, additional, Viney, Kerri, additional, Walters, Elisabetta G., additional, Warren, Joshua L., additional, Zar, Heather J., additional, Marais, Ben J., additional, Graham, Stephen M., additional, Debray, Thomas P. A., additional, Cohen, Ted, additional, and Seddon, James A., additional

Published
2022
Full Text
View/download PDF

56. Diagnostic Performance Assessment of Saliva RT-PCR and Nasopharyngeal Antigen for the Detection of SARS-CoV-2 in Peru

Author

Calderón, Roger I., primary, Jhaveri, Tulip A., additional, Tovar, Marco A., additional, Palomino, J. Santiago, additional, Barreda, Nadia N., additional, Sanabria, Oswaldo M., additional, Peinado, Jesús, additional, Ramirez, Claudio, additional, Llanos Zavalaga, L. Fernando, additional, Valderrama, Gissela, additional, Franke, Molly F., additional, Mitnick, Carole D., additional, Lecca, Leonid, additional, and Velásquez, Gustavo E., additional

Published
2022
Full Text
View/download PDF

63. Patient and Provider Perceptions of a Community-Based Accompaniment Intervention for Adolescents Transitioning to Adult HIV Care in Urban Peru: A Qualitative Analysis

Author

Galea, Jerome T, primary, Wong, Milagros, additional, Ninesling, Brennan, additional, Ramos, Alicia, additional, Senador, Liz, additional, Sanchez, Hugo, additional, Kolevic, Lenka, additional, Matos, Eduardo, additional, Sanchez, Eduardo, additional, Errea, Renato A., additional, Lindeborg, Andrew, additional, Benites, Carlos, additional, Lecca, Leonid, additional, Shin, Sonya, additional, and Franke, Molly F., additional

Published
2022
Full Text
View/download PDF

68. Safety and effectiveness outcomes from a 14-country cohort of patients with multi-drug resistant tuberculosis treated concomitantly with bedaquiline, delamanid and other second-line drugs

Author

Huerga, Helena, Khan, Uzma, Bastard, Mathieu, Mitnick, Carole D, Lachenal, Nathalie, Khan, Palwasha Y, Seung, Kwonjune J, Melikyan, Nara, Ahmed, Saman, Rich, Michael L, Varaine, Francis, Osso, Elna, Rashitov, Makhmujan, Salahuddin, Naseem, Salia, Gocha, Sánchez, Epifanio, Serobyan, Armine, Siddiqui, Muhammad Rafi, Tefera, Dri Grium, Vetushko, Dmitry, Yeghiazaryan, Lusine, Holtzman, David, Islam, Shirajul, Kumsa, Andargachew, Leblanc, Gamarly Jacques, Leonovich, Olga, Mamsa, Shahid, Manzur-Ul-Alam, Mohammad, Myint, Zaw, Padayachee, Shrivani, Franke, Molly F, Hewison, Catherine, and endTB study observational study team

Abstract

BACKGROUND: Concomitant use of bedaquiline (Bdq) and delamanid (Dlm) for multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) has raised concerns about a potentially poor risk-benefit ratio. Yet, this combination is an important alternative for patients infected with strains of TB with complex drug resistance profiles or who cannot tolerate other therapies. We assessed safety and treatment outcomes of MDR/RR-TB patients receiving concomitant Bdq and Dlm, along with other second-line anti-TB drugs. METHODS: We conducted a multi-centric, prospective observational cohort study across 14 countries among patients receiving concomitant Bdq-Dlm treatment. Patients were recruited between April 2015 and September 2018 and were followed until the end of treatment. All serious adverse events and adverse events of special interest (AESI), leading to a treatment change, or judged significant by a clinician, were systematically monitored and documented. RESULTS: Overall, 472 patients received Bdq and Dlm concomitantly. A large majority also received linezolid (89.6%) and clofazimine (84.5%). Nearly all (90.3%) had extensive disease; most (74.2%) had resistance to fluoroquinolones. The most common AESI were peripheral neuropathy (134, 28.4%) and electrolyte depletion (94, 19.9%). Acute kidney injury and myelosuppression were seen in 40 (8.5%) and 24 (5.1%) of patients, respectively. QT prolongation occurred in 7 (1.5%). Overall, 78.0% (358/458) had successful treatment outcomes, 8.9% died and 7.2% experienced treatment failure. CONCLUSIONS: Concomitant use of Bdq and Dlm, along with linezolid and clofazimine, is safe and effective for MDR/RR-TB patients with extensive disease. Using these drugs concomitantly is a good therapeutic option for patients with resistance to many anti-TB drugs.

Published
2022

69. Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis

Author

Aibana, Omowunmi, Huang, Chuan-Chin, Aboud, Said, Arnedo-Pena, Alberto, Becerra, Mercedes C., Bellido-Blasco, Juan Bautista, Bhosale, Ramesh, Calderon, Roger, Chiang, Silvia, Contreras, Carmen, Davaasambuu, Ganmaa, Fawzi, Wafaie W., Franke, Molly F., Galea, Jerome T., Garcia-Ferrer, Daniel, Gil-Fortuño, Maria, Gomila-Sard, Barbará, Gupta, Amita, Gupte, Nikhil, Hussain, Rabia, Iborra-Millet, Jesus, Iqbal, Najeeha T., Juan-Cerdán, Jose Vicente, Kinikar, Aarti, Lecca, Leonid, Mave, Vidya, Meseguer-Ferrer, Noemi, Montepiedra, Grace, Mugusi, Ferdinand M., Owolabi, Olumuyiwa A., Parsonnet, Julie, Roach-Poblete, Freddy, Romeu-García, Maria Angeles, Spector, Stephen A., Sudfeld, Christopher R., Tenforde, Mark W., Togun, Toyin O., Yataco, Rosa, Zhang, Zibiao, and Murray, Megan B.

Subjects
Tuberculosis -- Care and treatment -- Risk factors -- Development and progression, Vitamin D -- Health aspects, Vitamin D deficiency, HIV patients, Infection control, HIV, Households, Vitamins, Medical research, Health screening, Biological sciences
Abstract

Background Few studies have evaluated the association between preexisting vitamin D deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D levels on TB disease risk. Methods and findings We assessed the association between baseline vitamin D and incident TB in a prospective cohort of 6,751 HIV-negative household contacts of TB patients enrolled between September 1, 2009, and August 29, 2012, in Lima, Peru. We screened for TB disease at 2, 6, and 12 months after enrollment. We defined cases as household contacts who developed TB disease at least 15 days after enrollment of the index patient. For each case, we randomly selected four controls from among contacts who did not develop TB disease, matching on gender and year of age. We also conducted a one-stage individual-participant data (IPD) meta-analysis searching PubMed and Embase to identify prospective studies of vitamin D and TB disease until June 8, 2019. We included studies that assessed vitamin D before TB diagnosis. In the primary analysis, we defined vitamin D deficiency as 25-(OH)D 75nmol/L. We estimated the association between baseline vitamin D status and incident TB using conditional logistic regression in the Lima cohort and generalized linear mixed models in the meta-analysis. We further defined severe vitamin D deficiency as 25-(OH)D < 25 nmol/L and performed stratified analyses by HIV status in the IPD meta-analysis. In the Lima cohort, we analyzed 180 cases and 709 matched controls. The adjusted odds ratio (aOR) for TB risk among participants with baseline vitamin D deficiency compared to sufficient vitamin D was 1.63 (95% CI 0.75-3.52; p = 0.22). We included seven published studies in the meta-analysis and analyzed 3,544 participants. In the pooled analysis, the aOR was 1.48 (95% CI 1.04-2.10; p = 0.03). The aOR for severe vitamin D deficiency was 2.05 (95% CI 0.87-4.87; p trend for decreasing 25-(OH)D levels from sufficient vitamin D to severe deficiency = 0.02). Among 1,576 HIV-positive patients, vitamin D deficiency conferred a 2-fold (aOR 2.18, 95% CI 1.22-3.90; p = 0.01) increased risk of TB, and the aOR for severe vitamin D deficiency compared to sufficient vitamin D was 4.28 (95% CI 0.85-21.45; p = 0.08). Our Lima cohort study is limited by the short duration of follow-up, and the IPD meta-analysis is limited by the number of possible confounding covariates available across all studies. Conclusion Our findings suggest vitamin D predicts TB disease risk in a dose-dependent manner and that the risk of TB disease is highest among HIV-positive individuals with severe vitamin D deficiency. Randomized control trials are needed to evaluate the possible role of vitamin D supplementation on reducing TB disease risk., Author(s): Omowunmi Aibana 1, Chuan-Chin Huang 2, Said Aboud 3, Alberto Arnedo-Pena 4, Mercedes C. Becerra 2, Juan Bautista Bellido-Blasco 4, Ramesh Bhosale 5, Roger Calderon 6, Silvia Chiang 7, [...]

Published
2019
Full Text
View/download PDF

71. Safety of Treatment Regimens Containing Bedaquiline and Delamanid in the endTB Cohort

Author

Hewison, Catherine, primary, Khan, Uzma, additional, Bastard, Mathieu, additional, Lachenal, Nathalie, additional, Coutisson, Sylvine, additional, Osso, Elna, additional, Ahmed, Saman, additional, Khan, Palwasha, additional, Franke, Molly F, additional, Rich, Michael L, additional, Varaine, Francis, additional, Melikyan, Nara, additional, Seung, Kwonjune J, additional, Adenov, Malik, additional, Adnan, Sana, additional, Danielyan, Narine, additional, Islam, Shirajul, additional, Janmohamed, Aleeza, additional, Karakozian, Hayk, additional, Kamene Kimenye, Maureen, additional, Kirakosyan, Ohanna, additional, Kholikulov, Begimkul, additional, Krisnanda, Aga, additional, Kumsa, Andargachew, additional, Leblanc, Garmaly, additional, Lecca, Leonid, additional, Nkuebe, Mpiti, additional, Mamsa, Shahid, additional, Padayachee, Shrivani, additional, Thit, Phone, additional, Mitnick, Carole D, additional, and Huerga, Helena, additional

Published
2022
Full Text
View/download PDF

76. Disparities in SARS-CoV-2 exposure: evidence from a citywide seroprevalence study in Holyoke, Massachusetts, USA

Author

Matias, Wilfredo R., primary, Fulcher, Isabel R., additional, Sauer, Sara M., additional, Nolan, Cody P., additional, Guillaume, Yodeline, additional, Zhu, Jack, additional, Molano, Francisco J., additional, Uceta, Elizabeth, additional, Collins, Shannon, additional, Slater, Damien M., additional, Sánchez, Vanessa M., additional, Moheed, Serina, additional, Harris, Jason B., additional, Charles, Richelle C., additional, Paxton, Ryan M., additional, Gonsalves, Sean F., additional, Franke, Molly F., additional, and Ivers, Louise C., additional

Published
2021
Full Text
View/download PDF

78. Community-Based Accompaniment for Adolescents Transitioning to Adult HIV Care in Urban Peru: a Pilot Study

Author

Vargas, Valentina, primary, Wong, Milagros, additional, Rodriguez, Carly A., additional, Sanchez, Hugo, additional, Galea, Jerome, additional, Ramos, Alicia, additional, Senador, Liz, additional, Kolevic, Lenka, additional, Matos, Eduardo, additional, Sanchez, Eduardo, additional, Errea, Renato A., additional, Ramos, Karen, additional, Beckhorn, Catherine, additional, Lindeborg, Andrew, additional, Benites, Carlos, additional, Lecca, Leonid, additional, Shin, Sonya, additional, and Franke, Molly F., additional

Published
2021
Full Text
View/download PDF

80. Evaluation of the Access Bio CareStart™ rapid SARS-CoV-2 antigen test in asymptomatic individuals tested at a community mass-testing program in Western Massachusetts

Author

Suliman, Sara, primary, Matias, Wilfredo R., additional, Fulcher, Isabel R, additional, Molano, Francisco J., additional, Collins, Shannon, additional, Uceta, Elizabeth, additional, Zhu, Jack, additional, Paxton, Ryan M., additional, Gonsalves, Sean F., additional, Harden, Maegan V., additional, Fisher, Marissa, additional, Meldrim, Jim, additional, Gabriel, Stacey, additional, Franke, Molly F., additional, Hung, Deborah T., additional, Smole, Sandra C., additional, Madoff, Lawrence C., additional, and Ivers, Louise C., additional

Published
2021
Full Text
View/download PDF

81. All-oral longer regimens are effective for the management of multidrug-resistant tuberculosis in high-burden settings

Author

Khan, Palwasha Y., primary, Franke, Molly F., additional, Hewison, Catherine, additional, Seung, Kwonjune J., additional, Huerga, Helena, additional, Atwood, Sidney, additional, Ahmed, Saman, additional, Khan, Munira, additional, Sultana, Tanha, additional, Manzur-ul-Alam, Mohammad, additional, Vo, Luan N.Q., additional, Lecca, Leonid, additional, Yae, Kalkidan, additional, Kozhabekov, Serik, additional, Tamirat, Meseret, additional, Gelin, Alain, additional, Vilbrun, Stalz C., additional, Kikvidze, Marina, additional, Faqirzai, Jamil, additional, Kadyrov, Abdullaat, additional, Skrahina, Alena, additional, Mesic, Anita, additional, Avagyan, Nana, additional, Bastard, Mathieu, additional, Rich, Michael L., additional, Khan, Uzma, additional, and Mitnick, Carole D., additional

Published
2021
Full Text
View/download PDF

82. Prevalence of SARS-CoV-2 antibodies among market and city bus depot workers in Lima, Peru

Author

Tovar, Marco, primary, Peinado, Jesús, additional, Palomino, Santiago, additional, Llanos, Fernando, additional, Ramírez, Claudio, additional, Valderrama, Gisella, additional, Calderón, Roger I, additional, Williams, Roger B, additional, Velásquez, Gustavo E, additional, Mitnick, Carole D, additional, Franke, Molly F, additional, and Lecca, Leonid, additional

Published
2021
Full Text
View/download PDF

84. Multiple introductions of multidrug-resistant tuberculosis into households, Lima, Peru

Author

Cohen, Ted, Murray, Megan, Abubakar, Ibrahim, Zhang, Zibiao, Sloutsky, Alexander, Arteaga, Fernando, Chalco, Katiuska, Franke, Molly F., and Becerra, Mercedes C.

Subjects
Lima, Peru (City) -- Health aspects, Extensively drug-resistant tuberculosis -- Diagnosis -- Care and treatment -- Demographic aspects -- Research, Households -- Health aspects -- Research, Disease transmission -- Research -- Diagnosis -- Care and treatment, Health
Abstract

The discovery and use of discriminating genetic markers such as IS6110 restriction fragment length polymorphisms (RFLPs), spacer oligonucleotides (spoligotyping), and mycobacterial interspersed repetitive unit--variable number tandem repeats (MIRU-VNTRs) (1) have [...]

Published
2011
Full Text
View/download PDF

88. Culture Conversion in Patients Treated with Bedaquiline and/or Delamanid. A Prospective Multicountry Study

Author

Franke, Molly F., primary, Khan, Palwasha, additional, Hewison, Cathy, additional, Khan, Uzma, additional, Huerga, Helena, additional, Seung, Kwonjune J., additional, Rich, Michael L., additional, Zarli, Khin, additional, Samieva, Nazgul, additional, Oyewusi, Lawrence, additional, Nair, Parvati, additional, Mudassar, Mishaz, additional, Melikyan, Nara, additional, Lenggogeni, Putri, additional, Lecca, Leonid, additional, Kumsa, Andargachew, additional, Khan, Munira, additional, Islam, Shirajul, additional, Hussein, Kerow, additional, Docteur, Wisny, additional, Chumburidze, Nino, additional, Berikova, Elmira, additional, Atshemyan, Hakob, additional, Atwood, Sidney, additional, Alam, Manzurul, additional, Ahmed, Saman, additional, Bastard, Mathieu, additional, and Mitnick, Carole D., additional

Published
2021
Full Text
View/download PDF

91. Comprehensive treatment of extensively drug-resistant tuberculosis

Author

Mitnick, Carole D., Shin, Sonya S., Seung, Kwonjune J., Rich, Michael L., Atwood, Sidney S., Furin, Jennifer J., Fitzmaurice, Garrett M., Viru, Felix A. Alcantara, Appleton, Sasha C., Bayona, Jaime N., Bonilla, Cesar A., Chalco, Katiuska, Choi, Sharon, Franke, Molly F., Fraser, Hamish S.F., Guerra, Dalia, Hurtado, Rocio M., Jazayeri, Darius, Joseph, Keith, Llaro, Karim, Mestanza, Lorena, Mukherjee, Joia S., Munoz, Maribel, Palacios, Eda, Sanchez, Epifanio, Sloutsky, Alexander, and Becerra, Mercedes C.

Subjects
Tuberculosis -- Diagnosis, Tuberculosis -- Risk factors, Tuberculosis -- Care and treatment, Tuberculosis -- Patient outcomes, Ambulatory medical care -- Services
Abstract

A study was conducted to evaluate the comprehensive treatment outcomes for patients with extensively drug-resistant tuberculosis. Results indicated that extensively drug-resistant tuberculosis in HIV-negative patients can be cured through outpatient treatment.

Published
2008

93. Additional file 1 of Children as sentinels of tuberculosis transmission: disease mapping of programmatic data

Author

Gunasekera, Kenneth S., Zelner, Jon, Becerra, Mercedes C., Contreras, Carmen, Franke, Molly F., Lecca, Leonid, Murray, Megan B., Warren, Joshua L., and Cohen, Ted

Abstract

Additional file 1 : Supplementary Information, Table S1, Figure S1-S2. Supplementary Information – Log-Gaussian Cox process details and hierarchical Bayesian spatial model details. Table S1- Hierarchical Bayesian spatial model posterior parameter estimates. Fig S1 – Sensitivity analysis to child and adult age cut-offs. Fig S2 – Sensitivity analysis to grid size.

Published
2020
Full Text
View/download PDF

96. Prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies Among Market and City Bus Depot Workers in Lima, Peru.

Author

Tovar, Marco, Peinado, Jesús, Palomino, Santiago, Llanos, Fernando, Ramírez, Claudio, Valderrama, Gisella, Calderón, Roger I, Williams, Roger B, Velásquez, Gustavo E, Mitnick, Carole D, Franke, Molly F, and Lecca, Leonid

Subjects
COVID-19, EMPLOYEES, DISEASE prevalence, PUBLIC sector, VIRAL antibodies, GROCERY industry, TRANSPORTATION
Abstract

We report severe acute respiratory syndrome coronavirus 2 antibody positivity among market and city bus depot workers in Lima, Peru. Among 1285 vendors from 8 markets, prevalence ranged from 27% to 73%. Among 488 workers from 3 city bus depots, prevalence ranged from 11% to 47%. Self-reported symptoms were infrequent. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

100. Observational stepped-wedge analysis of a community health worker-led intervention for diabetes and hypertension in rural Mexico

Author

Worster, Devin T, primary, Franke, Molly F, additional, Bazúa, Rodrigo, additional, Flores, Hugo, additional, García, Zulema, additional, Krupp, Joanna, additional, Maza, Jimena, additional, Palazuelos, Lindsay, additional, Rodríguez, Katia, additional, Newman, Patrick M, additional, and Palazuelos, Daniel, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results