Search

Your search keyword '"Fragale, A"' showing total 7,455 results
Start Over "Fragale, A"

Refine your results

more »

more »

more »

more »

more »

more »

more »

more »
7,455 results on '"Fragale, A"'

51. Usability Testing of a New Digital Integrated Health Ecosystem (PainRELife) for the Clinical Management of Chronic Pain in Patients With Early Breast Cancer: Protocol for a Pilot Study

Author

Marianna Masiero, Chiara Filipponi, Silvia Francesca Maria Pizzoli, Elisabetta Munzone, Luca Guido, Vittorio Andrea Guardamagna, Sara Marceglia, Annamaria Caruso, Roberto Prandin, Marco Prenassi, Vania Manzelli, Chiara Savino, Costanza Conti, Federica Rizzi, Alice Casalino, Giulia Candiani, Francesca Memini, Luca Chiveri, Andrea Luigi Vitali, Massimo Corbo, Alessandra Milani, Roberto Grasso, Silvia Traversoni, Elisa Fragale, Florence Didier, and Gabriella Pravettoni

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundChronic pain (CP) and its management are critical issues in the care pathway of patients with breast cancer. Considering the complexity of CP experience in cancer, the international scientific community has advocated identifying cutting-edge approaches for CP management. Recent advances in the field of health technology enable the adoption of a novel approach to care management by developing integrated ecosystems and mobile health apps. ObjectiveThe primary end point of this pilot study is to evaluate patients’ usability experience at 3 months of a new digital and integrated technological ecosystem, PainRELife, for CP in a sample of patients with breast cancer. The PainRELife ecosystem is composed of 3 main technological assets integrated into a single digital ecosystem: Fast Healthcare Interoperability Resources–based cloud platform (Nu platform) that enables care pathway definition and data collection; a big data infrastructure connected to the Fast Healthcare Interoperability Resources server that analyzes data and implements dynamic dashboards for aggregate data visualization; and an ecosystem of personalized applications for patient-reported outcomes collection, digital delivery of interventions and tailored information, and decision support of patients and caregivers (PainRELife app). MethodsThis is an observational, prospective pilot study. Twenty patients with early breast cancer and chronic pain will be enrolled at the European Institute of Oncology at the Division of Medical Senology and the Division of Pain Therapy and Palliative Care. Each patient will use the PainRELife mobile app for 3 months, during which data extracted from the questionnaires will be sent to the Nu Platform that health care professionals will manage. This pilot study is nested in a large-scale project named “PainRELife,” which aims to develop a cloud technology platform to interoperate with institutional systems and patients' devices to collect integrated health care data. The study received approval from the Ethical Committee of the European Cancer Institute in December 2021 (number R1597/21-IEO 1701). ResultsThe recruitment process started in May 2022 and ended in October 2022. ConclusionsThe new integrated technological ecosystems might be considered an encouraging affordance to enhance a patient-centered approach to managing patients with cancer. This pilot study will inform about which features the health technological ecosystems should have to be used by cancer patients to manage CP. International Registered Report Identifier (IRRID)DERR1-10.2196/41216

Published
2023
Full Text
View/download PDF

52. FACTORES SOCIALES E INGRESO A LISTA DE ESPERA PARA TRASPLANTE RENAL.

Author

FRAGALE, GUILLERMO D., MAGENTA, MAURO, BEITIA, VANINA, KARL, ALEJANDRA, CLAROS, IVANA, RODRIGUEZ, LINA M., and TISI BAÑA, MATÍAS

Abstract

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

57. Musician and Artist Series: Ciarra Fragale

Subjects
Guitarists, Musicians, News, opinion and commentary, Sports and fitness
Abstract

Byline: Sam Manzella Photo by Jeannette LaPointe. Breakups are hard. Everyone copes differently when relationships come to a close -- and for 20-year-old singer-songwriter and third-year theater arts major Ciarra [...]

Published
2017

59. SFigure2 from Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia

Author

Raucci, Franca, primary, Vernieri, Claudio, primary, Di Tano, Maira, primary, Ligorio, Francesca, primary, Blaževitš, Olga, primary, Lazzeri, Samuel, primary, Shmahala, Anastasiya, primary, Fragale, Giuseppe, primary, Salvadori, Giulia, primary, Varano, Gabriele, primary, Casola, Stefano, primary, Buono, Roberta, primary, Visco, Euplio, primary, de Braud, Filippo, primary, and Longo, Valter D., primary

Published
2024
Full Text
View/download PDF

60. Supplementary Data from Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia

Author

Raucci, Franca, primary, Vernieri, Claudio, primary, Di Tano, Maira, primary, Ligorio, Francesca, primary, Blaževitš, Olga, primary, Lazzeri, Samuel, primary, Shmahala, Anastasiya, primary, Fragale, Giuseppe, primary, Salvadori, Giulia, primary, Varano, Gabriele, primary, Casola, Stefano, primary, Buono, Roberta, primary, Visco, Euplio, primary, de Braud, Filippo, primary, and Longo, Valter D., primary

Published
2024
Full Text
View/download PDF

61. WCN24-1598 EVALUATION OF THE OUTCOME OF KIDNEYS IMPLANTED FROM A DISCARDED PAIR IN THE PROVINCE OF BUENOS AIRES, ARGENTINA

Author

Petrone, Hugo, primary, Rial, María del carmen, additional, Ciappa, Martin, additional, Schiavelli, Ruben, additional, Raimondi, Clemente, additional, Dipietrantonio, Silvia, additional, Aleman, Silvina, additional, Pujol, Gervasio Soler, additional, Raffaele, Pablo, additional, Gonzales, Ignacio, additional, Novoa, Pablo, additional, Prado, Rodrigo, additional, Coccia, Paula, additional, Fragale, Guillermo, additional, and Leone, Francisco, additional

Published
2024
Full Text
View/download PDF

62. STable 1 from Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia

Author

Raucci, Franca, primary, Vernieri, Claudio, primary, Di Tano, Maira, primary, Ligorio, Francesca, primary, Blaževitš, Olga, primary, Lazzeri, Samuel, primary, Shmahala, Anastasiya, primary, Fragale, Giuseppe, primary, Salvadori, Giulia, primary, Varano, Gabriele, primary, Casola, Stefano, primary, Buono, Roberta, primary, Visco, Euplio, primary, de Braud, Filippo, primary, and Longo, Valter D., primary

Published
2024
Full Text
View/download PDF

63. Data from Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia

Author

Raucci, Franca, primary, Vernieri, Claudio, primary, Di Tano, Maira, primary, Ligorio, Francesca, primary, Blaževitš, Olga, primary, Lazzeri, Samuel, primary, Shmahala, Anastasiya, primary, Fragale, Giuseppe, primary, Salvadori, Giulia, primary, Varano, Gabriele, primary, Casola, Stefano, primary, Buono, Roberta, primary, Visco, Euplio, primary, de Braud, Filippo, primary, and Longo, Valter D., primary

Published
2024
Full Text
View/download PDF

66. Profile of Ernest S. Fragale Chairman of WesBanco, Inc

Subjects
WesBanco Inc., Chairpersons, Banking industry, Banking industry, General interest, News, opinion and commentary
Abstract

Wheeling: Following is the Profile of Ernest S. Fragale Chairman of WesBanco, Inc: Ernest S. Fragale has served as a member of the Board of Directors of the Corporation since [...]

Published
2016

71. Electric Bioimpedance Sensing for the Detection of Head and Neck Squamous Cell Carcinoma

Author

Andrea Luigi Camillo Carobbio, Zhuoqi Cheng, Tomaso Gianiorio, Francesco Missale, Stefano Africano, Alessandro Ascoli, Marco Fragale, Marta Filauro, Filippo Marchi, Luca Guastini, Francesco Mora, Giampiero Parrinello, Frank Rikki Mauritz Canevari, Giorgio Peretti, and Leonardo S. Mattos

Subjects
squamous cell carcinoma, electrical bioimpedance, cancer detection, classifier, head and neck cancer, machine learning, Medicine (General), R5-920
Abstract

The early detection of head and neck squamous cell carcinoma (HNSCC) is essential to improve patient prognosis and enable organ and function preservation treatments. The objective of this study is to assess the feasibility of using electrical bioimpedance (EBI) sensing technology to detect HNSCC tissue. A prospective study was carried out analyzing tissue from 46 patients undergoing surgery for HNSCC. The goal was the correct identification of pathologic tissue using a novel needle-based EBI sensing device and AI-based classifiers. Considering the data from the overall patient cohort, the system achieved accuracies between 0.67 and 0.93 when tested on tissues from the mucosa, skin, muscle, lymph node, and cartilage. Furthermore, when considering a patient-specific setting, the accuracy range increased to values between 0.82 and 0.95. This indicates that more reliable results may be achieved when considering a tissue-specific and patient-specific tissue assessment approach. Overall, this study shows that EBI sensing may be a reliable technology to distinguish pathologic from healthy tissue in the head and neck region. This observation supports the continuation of this research on the clinical use of EBI-based devices for early detection and margin assessment of HNSCC.

Published
2023
Full Text
View/download PDF

72. Two-Step Preparation of Protein-Decorated Biohybrid Quantum Dot Nanoparticles for Cellular Uptake

Author

Agata Noelia Traverso, David José Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gastón Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastián Yakisich, Mariano Grasselli, and Martín Radrizzani

Subjects
nanoparticles, transferrin, endocytosis, drug delivery, albumin, Pharmacy and materia medica, RS1-441
Abstract

Decoration of nanoparticles with specific molecules such as antibodies, peptides, and proteins that preserve their biological properties is essential for the recognition and internalization of their specific target cells. Inefficient preparation of such decorated nanoparticles leads to nonspecific interactions diverting them from their desired target. We report a simple two-step procedure for the preparation of biohybrid nanoparticles containing a core of hydrophobic quantum dots coated with a multilayer of human serum albumin. These nanoparticles were prepared by ultra-sonication, crosslinked using glutaraldehyde, and decorated with proteins such as human serum albumin or human transferrin in their native conformations. These nanoparticles were homogeneous in size (20–30 nm), retained the fluorescent properties of quantum dots, and did not show a “corona effect” in the presence of serum. The uptake of transferrin-decorated quantum dot nanoparticles was observed in A549 lung cancer and SH-SY5Y neuroblastoma cells but not in non-cancerous 16HB14o- or retinoic acid dopaminergic neurons differentiated SH-SY5Y cells. Furthermore, digitoxin-loaded transferrin-decorated nanoparticles decreased the number of A549 cells without effect on 16HB14o-. Finally, we analyzed the in vivo uptake of these biohybrids by murine retinal cells, demonstrating their capacity to selectively target and deliver into specific cell types with excellent traceability.

Published
2023
Full Text
View/download PDF

75. Richard Fragale

Subjects
School superintendents -- Appointments, resignations and dismissals, Retirement, Education, Social sciences
Abstract

Richard Fragale, superintendent, Central Union High School District, El Centro, [...]

Published
2004

77. Rehospitalización después del trasplante renal

Author

Claros, Ivana Alejandra, Magenta, Mauro, Rodríguez Cortés, Lina Marcela, Fragale, Guillermo, Tisi Baña, Matías, Claros, Ivana Alejandra, Magenta, Mauro, Rodríguez Cortés, Lina Marcela, Fragale, Guillermo, and Tisi Baña, Matías

Abstract

Introduction:Rehospitalization after renal transplantation predicts morbidity and mortality, is associated with higher costs, and indicates health care quality. Identifying risk factors for rehospitalization makes it possible to implement measures that improve the quality of care and develop interventions in the pre-transplant stage. Objectives: Establish the incidence of early rehospitalization in renal transplantation and evaluate variables associated with rehospitalization and its impact on the recipient and graft. Materials and Methods: Observational, longitudinal, retrospective study. We analyzed a cohort of adult kidney transplant patients from 01/01/2006 to 12/31/2018. Results: 196 adult kidney transplant patients were included in the study. The incidence of early rehospitalization was 17.8% (n=35). Patient and graft survival were similar in both groups. The cause of death was predominantly infectious 52% (n=22), while the cause of graft loss was chronic allograft nephropathy 24% (n=14) and death with a functioning graft 48% (n=28). Conclusions: The incidence of early rehospitalization after renal transplantation in our center is low compared to other publications. Our study did not show that readmission after renal transplantation is associated with worse outcomes, Introducción: La rehospitalización después del trasplante renal es un predictor de morbimortalidad, se asocia a mayores costos y es un indicador de calidad de atención de la salud. La identificación de factores de riesgo de rehospitalización permite implementar medidas que mejoren la calidad de atención y desarrollar intervenciones que puedan ser aplicadas en la etapa pretrasplante. Objetivos: Establecer la incidencia de rehospitalización temprana en trasplante renal, evaluar variables asociadas a rehospitalización y su impacto en el receptor e injerto. Materiales y Métodos: Estudio observacional, longitudinal, retrospectivo. Se analizó una cohorte de pacientes trasplantados renales adultos en el período comprendido desde el 01/01/2006 al 31/12/2018. Resultados: Se incluyeron 196 pacientes adultos trasplantados renales en el período de estudio. La incidencia de rehospitalización temprana fue de 17.8% (n=35). La supervivencia del paciente y del injerto fueron similares en ambos grupos. La causa de muerte fue predominantemente infecciosa 52%(n=22), mientras que la causa de pérdida del injerto fue la nefropatía crónica del injerto 24%(n=14) y la muerte con injerto funcionante del 48%(n=28). Conclusiones: La incidencia de rehospitalización temprana postrasplante renal de nuestro centro es baja comparado a otras publicaciones. Nuestro estudio no mostró que la reinternación postrasplante renal se asocie a peores resultados.

Published
2024

78. CD8+CD103+PD1+TIM3+ T cells in glioblastoma microenvironment correlate with prognosis

Author

Romagnoli, Giulia, D'Alessandris, Quintino Giorgio, Capone, Imerio, Tavilla, Andrea, Canini, Irene, Lapenta, Caterina, Buccarelli, Mariachiara, Giordano, Martina, Tirelli, Valentina, Sanchez, Massimo, Fragale, Alessandra, Giannetti, Stefano, Di Bonaventura, Rina, Lauretti, Liverana, Biffoni, Mauro, Ricci‐vitiani, Lucia, Pallini, Roberto, Gabriele, Lucia, D'Alessandris, Quintino Giorgio (ORCID:0000-0002-2953-9291), Giannetti, Stefano (ORCID:0000-0002-9456-8865), Lauretti, Liverana (ORCID:0000-0002-6463-055X), Pallini, Roberto (ORCID:0000-0002-4611-8827), Romagnoli, Giulia, D'Alessandris, Quintino Giorgio, Capone, Imerio, Tavilla, Andrea, Canini, Irene, Lapenta, Caterina, Buccarelli, Mariachiara, Giordano, Martina, Tirelli, Valentina, Sanchez, Massimo, Fragale, Alessandra, Giannetti, Stefano, Di Bonaventura, Rina, Lauretti, Liverana, Biffoni, Mauro, Ricci‐vitiani, Lucia, Pallini, Roberto, Gabriele, Lucia, D'Alessandris, Quintino Giorgio (ORCID:0000-0002-2953-9291), Giannetti, Stefano (ORCID:0000-0002-9456-8865), Lauretti, Liverana (ORCID:0000-0002-6463-055X), and Pallini, Roberto (ORCID:0000-0002-4611-8827)

Abstract

Glioblastoma, isocitrate dehydrogenase-wildtype (GB), is the most common and aggressive primary brain malignancy with poor outcome. Immune checkpoint inhibitors (ICIs) have been tested in GB and, despite disappointing results, the identification of a small subgroup of responders underlies the need to improve our understanding of the tumour microenvironment (TME) immunity. This study aimed to determine whether the expression of selected immune checkpoints on tissue-resident memory T cells (Trm) may predict patient outcome. We conducted a single cohort observational study. Tumour samples were collected from 45 patients with histologically confirmed GB (WHO grade 4) and processed to obtain single-cell suspensions. Patients were assessed for the correlation of Trm phenotype with overall survival (OS) or progression-free survival (PFS) using multiparametric flow cytometry and uni/multivariate analyses. Levels of Trm expressing programmed cell death protein 1 (PD1) and T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) were found to be linked to clinical outcome. Low frequency of Trm expressing PD1 or TIM3 or both markers defined subgroups as independent positive prognostic factors for patient survival. On multivariate analysis, low CD8+CD103+PD1+TIM3+ Trm and Karnofsky performance status (KPS) >= 70 were confirmed to be the most predictive independent factors associated with longer OS (hazard ratios-HR [95%CI]: 0.14 [0.04-0.52] p < 0.001, 0.39 [0.16-0.96] p = 0.04, respectively). The CD8+CD103+ Trm subgroups were also age-related predictors for survival in GB.

Published
2024

79. RAF1 gene fusions are recurrent driver events in infantile fibrosarcoma‐like mesenchymal tumors.

Author

Motta, Marialetizia, Barresi, Sabina, Pizzi, Simone, Bifano, Delfina, Lopez Marti, Jennifer, Garrido‐Pontnou, Marta, Flex, Elisabetta, Bruselles, Alessandro, Giovannoni, Isabella, Rotundo, Giovannina, Fragale, Alessandra, Tirelli, Valentina, Vallese, Silvia, Ciolfi, Andrea, Bisogno, Gianni, Alaggio, Rita, and Tartaglia, Marco

Subjects
GENE fusion, CHIMERIC proteins, GENE rearrangement, HYPERACTIVITY, CATALYTIC domains, RECURRENT miscarriage
Abstract

Infantile fibrosarcomas (IFS) and congenital mesoblastic nephroma (CMN) are rare myofibroblastic tumors of infancy and early childhood commonly harboring the ETV6::NTRK3 gene fusion. IFS/CMN are considered as tumors with an 'intermediate prognosis' as they are locally aggressive, but rarely metastasize, and generally have a favorable outcome. A fraction of IFS/CMN‐related neoplasms are negative for the ETV6::NTRK3 gene rearrangement and are characterized by other chimeric proteins promoting MAPK signaling upregulation. In a large proportion of these tumors, which are classified as IFS‐like mesenchymal neoplasms, the contributing molecular events remain to be identified. Here, we report three distinct rearrangements involving RAF1 among eight ETV6::NTRK3 gene fusion‐negative tumors with an original histological diagnosis of IFS/CMN. The three fusion proteins retain the entire catalytic domain of the kinase. Two chimeric products, GOLGA4::RAF1 and LRRFIP2::RAF1, had previously been reported as driver events in different cancers, whereas the third, CLIP1::RAF1, represents a novel fusion protein. We demonstrate that CLIP1::RAF1 acts as a bona fide oncoprotein promoting cell proliferation and migration through constitutive upregulation of MAPK signaling. We show that the CLIP1::RAF1 hyperactive behavior does not require RAS activation and is mediated by constitutive 14‐3‐3 protein‐independent dimerization of the chimeric protein. As previously reported for the ETV6::NTRK3 fusion protein, CLIP1::RAF1 similarly upregulates PI3K‐AKT signaling. Our findings document that RAF1 gene rearrangements represent a recurrent event in ETV6::NTRK3‐negative IFS/CMN and provide a rationale for the use of inhibitors directed to suppress MAPK and PI3K‐AKT signaling in these cancers. © 2024 The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

80. Support for Chronic Pain Management for Breast Cancer Survivors Through Novel Digital Health Ecosystems: Pilot Usability Study of the PainRELife Mobile App

Author

Masiero, Marianna, primary, Filipponi, Chiara, additional, Fragale, Elisa, additional, Pizzoli, Silvia Francesca Maria, additional, Munzone, Elisabetta, additional, Milani, Alessandra, additional, Guido, Luca, additional, Guardamagna, Vittorio, additional, Marceglia, Sara, additional, Prandin, Roberto, additional, Prenassi, Marco, additional, Caruso, Annamaria, additional, Manzelli, Vania, additional, Savino, Chiara, additional, Conti, Costanza, additional, Rizzi, Federica, additional, Casalino, Alice, additional, Candiani, Giulia, additional, Memini, Francesca, additional, Chiveri, Luca, additional, Vitali, Andrea Luigi, additional, Corbo, Massimo, additional, Grasso, Roberto, additional, Didier, Florence, additional, Ferrucci, Roberta, additional, and Pravettoni, Gabriella, additional

Published
2024
Full Text
View/download PDF

83. Cyclic fasting-mimicking diet plus bortezomib and rituximab is an effective treatment for chronic lymphocytic leukemia

Author

Raucci, Franca, primary, Vernieri, Claudio, additional, Di Tano, Maira, additional, Ligorio, Francesca, additional, Blaževitš, Olga, additional, Lazzeri, Samuel, additional, Shmahala, Anastasiya, additional, Fragale, Giuseppe, additional, Salvadori, Giulia, additional, Varano, Gabriele, additional, Casola, Stefano, additional, Buono, Roberta, additional, Visco, Euplio, additional, de Braud, Filippo, additional, and Longo, Valter D., additional

Published
2024
Full Text
View/download PDF

84. Correction: A Machine Learning Model to Predict Patients’ Adherence Behavior and a Decision Support System for Patients With Metastatic Breast Cancer: Protocol for a Randomized Controlled Trial

Author

Masiero, Marianna, primary, Spada, Gea Elena, additional, Sanchini, Virginia, additional, Munzone, Elisabetta, additional, Pietrobon, Ricardo, additional, Teixeira, Lucas, additional, Valencia, Mirtha, additional, Machiavelli, Aline, additional, Fragale, Elisa, additional, Pezzolato, Massimo, additional, and Pravettoni, Gabriella, additional

Published
2024
Full Text
View/download PDF

85. Correction: A Machine Learning Model to Predict Patients’ Adherence Behavior and a Decision Support System for Patients With Metastatic Breast Cancer: Protocol for a Randomized Controlled Trial (Preprint)

Author

Masiero, Marianna, primary, Spada, Gea Elena, additional, Sanchini, Virginia, additional, Munzone, Elisabetta, additional, Pietrobon, Ricardo, additional, Teixeira, Lucas, additional, Valencia, Mirtha, additional, Machiavelli, Aline, additional, Fragale, Elisa, additional, Pezzolato, Massimo, additional, and Pravettoni, Gabriella, additional

Published
2023
Full Text
View/download PDF

86. A Machine Learning Model to Predict Patients’ Adherence Behavior and a Decision Support System for Patients With Metastatic Breast Cancer: Protocol for a Randomized Controlled Trial

Author

Masiero, Marianna, primary, Spada, Gea Elena, additional, Sanchini, Virginia, additional, Munzone, Elisabetta, additional, Pietrobon, Ricardo, additional, Teixeira, Lucas, additional, Valencia, Mirtha, additional, Machiavelli, Aline, additional, Fragale, Elisa, additional, Pezzolato, Massimo, additional, and Pravettoni, Gabriella, additional

Published
2023
Full Text
View/download PDF

88. Overview of different modified full-face snorkelling masks for intraoperative protection

Author

Claudio Vicini, Giovanni Cammaroto, Giuseppe Meccariello, Giannicola Iannella, Marco Fragale, Tommaso Cacco, Claudio Sampieri, Luca Guastini, Eolo Castello, Giampiero Parrinello, Andrea De Vito, Giampiero Gulotta, Irene Claudia Visconti, Pietro Abita, Stefano Pelucchi, Giulia Bianchi, Michela Nicole Melegatti, Gianluca Garulli, Filippo Bosco, Alessandro Gennaiotti, Stefano Berrettini, Massimo Magnani, Marco Troncossi, and Giorgio Peretti

Subjects
Otorhinolaryngology, RF1-547
Published
2020
Full Text
View/download PDF

90. Rehospitalización después del trasplante renal.

Author

Alejandra Claros, Ivana, Magenta, Mauro, Rodríguez Cortés, Lina Marcela, Fragale, Guillermo, and Tisi Baña, Matías

Subjects
MEDICAL quality control, KIDNEY transplantation, PATIENT readmissions, GRAFT survival, CAUSES of death
Abstract

Copyright of Revista de Nefrología Diálisis y Trasplante is the property of Asociacion Regional de Dialisis y Transplantes Regionale and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

91. Patrick Fragale Joins Fareportal Executive Board

Subjects
Business, general
Abstract

NEW YORK (PRWEB) April 23, 2014 Fareportal, a technology company that powers leading travel agencies CheapOair and OneTravel, announced today that Patrick Fragale has joined its team as the new [...]

Published
2014

93. Evaluation of the Rate of Problem Behavior Maintained by Different Reinforcers across Preference Assessments

Author

Kang, Soyeon, O'Reilly, Mark F., and Fragale, Christina L.

Abstract

The rates of problem behavior maintained by different reinforcers were evaluated across 3 preference assessment formats (i.e., paired stimulus, multiple-stimulus without replacement, and free operant). The experimenter administered each assessment format 5 times in a random order for 7 children with developmental disabilities whose problem behavior was maintained by attention, tangible items, or escape. Results demonstrated different effects related to the occurrence of problem behavior, suggesting an interaction between function of problem behavior and assessment format. Implications for practitioners are discussed with respect to assessing preferences of individuals with developmental disabilities who exhibit problem behavior. (Contains 3 figures.)

Published
2011

96. Assessment of the Language Preferences of Five Children with Autism from Spanish-Speaking Homes

Author

Aguilar, Jeannie M., Chan, Jeffrey M., White, Pamela J., and Fragale, Christina

Abstract

Although the number of English Language Learner students is increasing in the US school system, little is known about the preferences of language of instruction, particularly among young students with autism. We implemented a choice assessment with five children with autism to determine preference between English and Spanish instruction using a concurrent-operant design. Participants were allowed to choose between English instruction, Spanish instruction, and a no-language control condition using BIGmack communication devices. We compared choice allocation between previously mastered skills (easy tasks) and targets in the acquisition phase of learning (difficult tasks). None of the participants indicated a preference for language of instruction during easy tasks, while four participants indicated a preference during difficult tasks. Results suggest that the concurrent-operant procedure is an effective method for assessing preference of language of instruction with students with autism.

Published
2017
Full Text
View/download PDF

97. Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex

Author

Tae Won Yi, Brendan Smyth, Gian Luca Di Tanna, Clare Arnott, Kathryn Cardoza, Amy Kang, Carol Pollock, Rajiv Agarwal, George Bakris, David M. Charytan, Dick de Zeeuw, Hiddo J.L. Heerspink, Bruce Neal, David C. Wheeler, Christopher P. Cannon, Hong Zhang, Bernard Zinman, Vlado Perkovic, Adeera Levin, Kenneth W. Mahaffey, Meg Jardine, Barry M. Brenner, Tom Greene, Meg J. Jardine, Gary Meininger, Nicole Li, Inna Kolesnyk, Diego Aizenberg, Roberto Pecoits-Filho, David Cherney, Gregorio Obrador, Glenn Chertow, Tara Chang, Carmel Hawley, Linong Ji, Takashi Wada, Vivekanand Jha, Soo Kun Lim, Mary Anne Lim-Abrahan, Florence Santos, Dong-Wan Chae, Shang-Jyh Hwang, Evgueniy Vazelov, Ivan Rychlík, Samy Hadjadj, Vera Krane, László Rosivall, Luca De Nicola, Alexander Dreval, Michał Nowicki, Adalbert Schiller, Larry Distiller, Jose L. Górriz, Mykola Kolesnyk, null David, C. Wheeler, Rodolfo Andres Ahuad Guerrero, Juan Pablo Albisu, Andres Alvarisqueta, Ines Bartolacci, Mario Alberto Berli, Anselmo Bordonava, Pedro Calella, Maria Cecilia Cantero, Luis Rodolfo Cartasegna, Esteban Cercos, Gabriela Cecilia Coloma, Hugo Colombo, Victor Commendatore, Jesus Cuadrado, Carlos Alberto Cuneo, Ana Maria Cusumano, Walter Guillermo Douthat, Ricardo Dario Dran, Eduardo Farias, Maria Florencia Fernandez, Hernan Finkelstein, Guillermo Fragale, Jose Osvaldo Fretes, Nestor Horacio Garcia, Anibal Gastaldi, Elizabeth Gelersztein, Jorge Archibaldo Glenny, Joaquin Pablo Gonzalez, Patricia del Carmen Gonzalez Colaso, Claudia Goycoa, Gustavo Cristian Greloni, Adrian Guinsburg, Sonia Hermida, Luis Isaias Juncos, Maria Isabel Klyver, Florencia Kraft, Fernando Krynski, Paulina Virginia Lanchiotti, Ricardo Alfonso Leon de la Fuente, Nora Marchetta, Pablo Mele, Silvia Nicolai, Pablo Antonio Novoa, Silvia Ines Orio, Fabian Otreras, Alejandra Oviedo, Pablo Raffaele, Jorge Hector Resk, Lucas Rista, Nelson Rodriguez Papini, Jorgelina Sala, Juan Carlos Santos, Lilia Beatriz Schiavi, Horacio Sessa, Tomas Smith Casabella, Maria Rosa Ulla, Maria Valdez, Augusto Vallejos, Adriana Villarino, Virginia Esther Visco, Alfredo Wassermann, Cesar Javier Zaidman, Ngai Wah Cheung, Carolyn Droste, Ian Fraser, David Johnson, Peak Mann Mah, Kathy Nicholls, David Packham, Joseph Proietto, Anthony Roberts, Simon Roger, Venessa Tsang, Roberto Abrão Raduan, Fernando Augusto Alves da Costa, Celso Amodeo, Luiz Alberto Andreotti Turatti, Rachel Bregman, Fernanda Cristina Camelo Sanches, Luis Henrique Canani, Antônio Roberto Chacra, João Lindolfo Cunha Borges, Sérgio Alberto Cunha Vêncio, Roberto Jorge da Silva Franco, Domingos d’Avila, Evandro de Souza Portes, Pedro de Souza, Luciane Mônica Deboni, Fadlo Fraige Filho, Bruno Geloneze Neto, Marcus Gomes, Suely Keiko Kohara, Elizete Keitel, Jose Francisco Kerr Saraiva, Hugo Roberto Kurtz Lisboa, Fabiana Loss de Carvalho Contieri, Rosângela Milagres, Renan Montenegro Junior, Claudia Moreira de Brito, Miguel Nasser Hissa, Ângela Regina Nazario Sabbag, Irene Noronha, Daniel Panarotto, Roberto Pecoits Filho, Márcio Antônio Pereira, Wladmir Saporito, Antonio Scafuto Scotton, Tiago Schuch, Roberto Simões de Almeida, Cássio Slompo Ramos, João Soares Felício, Fernando Thomé, Jean Carlo Tibes Hachmann, Sérgio Yamada, Cesar Yoiti Hayashida, Tarissa Beatrice Zanata Petry, Maria Teresa Zanella, Viktoria Andreeva, Angelina Angelova, Stefan Dimitrov, Veselka Genadieva, Gabriela Genova-Hristova, Kiril Hristozov, Zdravko Kamenov, Atanas Koundurdjiev, Lachezar Lozanov, Viktor Margaritov, Boyan Nonchev, Rangel Rangelov, Alexander Shinkov, Margarita Temelkova, Ekaterina Velichkova, Andrian Yakov, Naresh Aggarwal, Ronnie Aronson, Harpreet Bajaj, Guy Chouinard, James Conway, Serge Cournoyer, Gerald DaRoza, Sacha De Serres, François Dubé, Ronald Goldenberg, Anil Gupta, Milan Gupta, Sam Henein, Hasnain Khandwala, Lawrence Leiter, François Madore, Alan McMahon, Norman Muirhead, Vincent Pichette, Remi Rabasa-Lhoret, Andrew Steele, Navdeep Tangri, Ali Torshizi, Vincent Woo, Nadia Zalunardo, María Alicia Fernández Montenegro, Juan Gonzalo Godoy Jorquera, Marcelo Medina Fariña, Victor Saavedra Gajardo, Margarita Vejar, Nan Chen, Qinkai Chen, Shenglian Gan, Yaozhong Kong, Detian Li, Wenge Li, Xuemei Li, Hongli Lin, Jian Liu, Weiping Lu, Hong Mao, Yan Ren, Weihong Song, Jiao Sun, Lin Sun, Ping Tu, Guixia Wang, Jinkui Yang, Aiping Yin, Xueqing Yu, Minghui Zhao, Hongguang Zheng, Jose Luis Accini Mendoza, Edgar Arcos, Jorge Avendano, Jorge Ernesto Andres Diaz Ruiz, Luis Hernando Garcia Ortiz, Alexander Gonzalez, Eric Hernandez Triana, Juan Diego Higuera, Natalia Malaver, Dora Inés Molina de Salazar, Ricardo Rosero, Monica Alexandra Terront Lozano, Luis Valderrama Cometa, Alex Valenzuela, Ruben Dario Vargas Alonso, Ivan Villegas, Hernan Yupanqui, Dagmar Bartaskova, Petr Barton, Jana Belobradkova, Lenka Dohnalova, Tomas Drasnar, Richard Ferkl, Katarina Halciakova, Vera Klokocnikova, Richard Kovar, Jiri Lastuvka, Martin Lukac, Satu Pesickova, Karel Peterka, Jiri Pumprla, Ivan Rychlik, Frantisek Saudek, Vladimir Tesar, Martin Valis, Pavel Weiner, Stanislav Zemek, Eric Alamartine, Sophie Borot, Bertrand Cariou, Bertrand Dussol, Jean-Pierre Fauvel, Pierre Gourdy, Alexandre Klein, Yannick Le Meur, Alfred Penfornis, Ronan Roussel, Pierre-Jean Saulnier, Eric Thervet, Philippe Zaoui, Volker Burst, Markus Faghih, Grit Faulmann, Hermann Haller, Reinhold Jerwan-Keim, Stephan Maxeiner, Björn Paschen, Georg Plassmann, Ludger Rose, Ronaldo Arturo Gonzalez Orellana, Franklin Paul Haase, Juan Pablo Moreira Diaz, Luis Alberto Ramirez Roca, Jose Antonio Sánchez Arenales, José Vicente Sanchez Polo, Erick Turcios Juarez, Gyongyi Csecsei, Botond Csiky, Peter Danos, Laszlo Deak, Mihaly Dudas, Eleonora Harcsa, Katalin Keltai, Sandor Keresztesi, Krisztian Kiss, Laszlo Konyves, Lajos Major, Margit Mileder, Marta Molnar, Janos Mucsi, Tamas Oroszlan, Ivan Ory, Gyorgy Paragh, Eva Peterfai, Gizella Petro, Katalin Revesz, Robert Takacs, Sandor Vangel, Szilard Vasas, Marianna Zsom, Oomman Abraham, Raju Sree Bhushan, Dewan Deepak, Fernando M. Edwin, Natarajan Gopalakrishnan, Noble Gracious, Alva Hansraj, Dinesh Jain, C.B. Keshavamurthy, Dinesh Khullar, Sahay Manisha, Jayameena Peringat, Narayan Prasad, Rao K. Satyanarayana, Reddy Sreedhar, Melemadathil Sreelatha, Bhimavarapu Sudhakar, Ramesh Chandra Vyasam, Riccardo Bonadonna, Pietro Castellino, Antonio Ceriello, Luca Chiovato, Salvatore De Cosmo, Giuseppe Derosa, Alberto Di Carlo, Graziano Di Cianni, Giovanni Frascà, Giorgio Fuiano, Giovanni Gambaro, Giacomo Garibotto, Carlo Giorda, Fabio Malberti, Marcora Mandreoli, Edoardo Mannucci, Emanuela Orsi, Piermarco Piatti, Domenico Santoro, Ferdinando Carlo Sasso, Gaetano Serviddio, Andrea Stella, Roberto Trevisan, Anna Maria Veronelli, Luca Zanoli, Hitoshi Akiyama, Hiromi Aoki, Akimichi Asano, Tadashi Iitsuka, Shizuo Kajiyama, Susumu Kashine, Toshio Kawada, Takamoto Kodera, Hiroshi Kono, Kazunori Koyama, Yasuro Kumeda, Shozo Miyauchi, Kazuyuki Mizuyama, Tetsuji Niiya, Hiroko Oishi, Satoshi Ota, Terue Sakakibara, Masahiko Takai, Osamu Tomonaga, Mitsuru Tsujimoto, Masakiyo Wakasugi, Yasushi Wakida, Takayuki Watanabe, Masayo Yamada, Kazuhiro Yanagida, Toshihiko Yanase, Wataru Yumita, Egle Gaupsiene, Dalia Kozloviene, Antanas Navickas, Egle Urbanaviciene, Rohana Abdul Ghani, Khalid Abdul Kadir, Norsiah Ali, Mohd Daud Che Yusof, Chye Lee Gan, Mastura Ismail, Wei Yen Kong, Swee Win Lam, Li Yuan Lee, Chek Loong Loh, Anita Bhajan Manocha, Kee Sing Ng, Nik Nur Fatnoon Nik Ahmad, Vanassa Ratnasingam, Saiful Shahrizal Bin Shudim, Paranthaman Vengadasalam, Luis David Abraira Munoz, Melchor Alpizar Salazar, Juan Baas Cruz, Mario Burgos Soto, Jose Chevaile Ramos, Alfredo Chew Wong, Jose Ricardo Correa Rotter, Tonatiu Diaz Escalante, Favio Edmundo Enriquez Sosa, Fernando Flores Lozano, Luis Fernando Flota Cervera, Paul Frenk Baron, Cecilia Garcia Ballesteros, Jose David Gomez Rangel, Luis Enrique Herrera Jimenez, Sergio Saul Irizar Santana, Fernando Jimenez Flores, Hugo Laviada Molina, Rosa Isela Luna Ceballos, Belia Martin del Campo Blanco, Guadalupe Morales Franco, Oscar Tarsicio Moreno Loza, Cynthia Mustieles Rocha, Gregorio Obrador Vera, Ricardo Orozco Castellanos, Juan Peralta Calcaneo, Miguel Angel Reyes Rosano, Hiromi Rodriguez Pattzi, Juan Rosas Guzman, Isabel Erika Rucker Joerg, Sandra Berenice Saavedra Sanchez, Jose Hector Sanchez Mijangos, Pablo Serrano Sanson, Juan Alfredo Tamayo y Orozco, Eloisa Tellez Chavez, Alejandro Valdes Cepeda, Luis Venegas Carrillo, Juan Villagordoa Mesa, Rolando Zamarripa Escobedo, John Baker, Paul Noonan, Russell Scott, Robert Walker, Edward Watson, Michael Williams, Simon Young, Zaynab Abejuela, Jeimeen Agra, Grace Aquitania, Clodoaido Caringal, Rhea Severina Comia, Lalaine Delos Santos, Olivert Gomez, Cecilia Jimeno, Gerry Tan, Marsha Tolentino, Christy Yao, Yvette Ethel Yap, Ma. Dovie Lallaine Ygpuara, Renata Bijata-Bronisz, Lucyna Hotlos, Andrzej Januszewicz, Barbara Kaczmarek, Anna Kaminska, Lech Lazuka, Andrzej Madej, Stanislaw Mazur, Dorota Mlodawska-Choluj, Michal Nowicki, Grazyna Orlowska-Kowalik, Grazyna Popenda, Barbara Rewerska, Dariusz Sowinski, Liliana Monica Angelescu, Veronica Anghel, Rodica-Ioana Avram, Mihaela-Magdalena Busegeanu, Adriana Cif, Dana Cosma, Carmen Crisan, Luiza Despina Demian, Ioana Emilia Ferariu, Ildiko Halmagyi, Nicolae Hancu, Mircea Munteanu, Doru Negru, Adriana Gabriela Onaca, Ligia Petrica, Amorin Remus Popa, Aurelian-Emil Ranetti, Cristian Serafinceanu, Cristina Toarba, Alina Agafyina, Olga Barbarash, Olga Barysheva, Daniil Chizhov, Vladimir Dobronravov, Irina Glinkina, Elena Grineva, Vladimir Khirmanov, Elena Kolmakova, Tatiana Koroleva, Liudmila Kvitkova, Viacheslav Marasaev, Ashot Mkrtumyan, Tatiana Morugova, Galina Nagibovich, Oleg Nagibovich, Sergei Nedogoda, Irina Osipova, Tatiana Raskina, Yulia Samoylova, Olga Sazonova, Minara Shamkhalova, Elena Shutemova, Yuriy Shwartz, Oleg Uriasyev, Sergey Vorobyev, Anna Zateyshchikova, Dmitry Zateyshshikov, Tatyana Zykova, Slobodan Antic, Miodrag Djordjevic, Aleksandra Kendereski, Katarina Lalic, Nebojsa Lalic, Vesna Popovic-Radinovic, Jana Babikova, Olga Benusova, Ingrid Buganova, Jan Culak, Andrej Dzupina, Jana Dzuponova, Peter Fulop, Adriana Ilavska, Emil Martinka, Zuzana Ochodnicka, Daniel Pella, Iveta Smatanova, Fayzal Ahmed, Aysha Badat, Johannes Breedt, Lawrence Distiller, Vimladhevi Govender, Ravendran Govender, Mukesh Joshi, Jaco Jurgens, Gulam Latiff, Landman Lombard, Mohamed Mookadam, Nomangesi Ngcakani, Hendrik Nortje, Helena Oosthuizen, Larisha Pillay-Ramaya, Hans Prozesky, Jeevren Reddy, Paul Rheeder, Mary Seeber, Young Min Cho, In-Kyung Jeong, Sin Gon Kim, Yeong Hoon Kim, Hyuk-Sang Kwon, Min Jeong Kwon, Byung-Wan Lee, JungEun Lee, Moon-Kyu Lee, Moon-Suk Nam, Kook-Hwan Oh, Cheol- Young Park, Sun-Hee Park, Kun Ho Yoon, Pere Alvarez Garcia, Luis Asmarats Mercadal, Clara Barrios, Fernando Cereto Castro, Secundino Cigarran Guldris, Marta Dominguez Lopez, Jesus Egido de los Rios, Gema Fernandez Fresnedo, Antonio Galan Serrano, Isabel Garcia, Francisco Javier Gonzalez Martinez, Jose Esteban Jodar Gimeno, Manuel Lopez Mendoza, Tamara Malek Marin, Cristobal Morales Portillo, Maria Antonia Munar Vila, Manuel Muñoz Torres, Javier Nieto Iglesias, Jonay Pantoja Perez, Merce Perez Vera, Jose M. Portoles Perez, María Angustias Quesada Simón, Rafael Simo Canonge, Alfonso Soto Gonzalez, Manel Terns Riera, Francisco Jose Tinahones Madueno, Mercedes Velo Plaza, Chwen-Tzuei Chang, Lee-Ming Chuang, Te-Lin Hsia, Chang-Hsun Hsieh, Chih-Ching Lin, Yung- Chuan Lu, Wayne H-H Sheu, Olga Barna, Svitlana D. Bilyk, Volodymyr Botsyurko, Iryna Dudar, Ivan Fushtey, Olga Godlevska, Oleksandr Golovchenko, Olga Gyrina, Anatoliy Kazmirchuk, Iuliia Komisarenko, Oleksii Korzh, Nonna Kravchun, Oleg Legun, Borys Mankovskyy, Liliya Martynyuk, Yuriy Mostovoy, Nataliia Pashkovska, Larysa Pererva, Tetyana Pertseva, Oleksandr Samoylov, Ivan Smirnov, Yevgeniya Svyshchenko, Halyna Tomashkevych, Ivan Topchii, Nadiya Tryshchuk, Vira Tseluyko, Vadym Vizir, Maryna Vlasenko, Tetiana Zlova, Liliia Zub, Salah Abusnana, Mohamed Railey, Kamal Abouglila, Paul Ainsworth, Zishan Ali, Vijayaraman Arutchelvam, Maria Barnard, Srikanth Bellary, Emyr Davies, Mark Davies, Simon Davies, Alison Dawson, Mohsen El Kossi, Patrick English, Donald Fraser, Luigi Gnudi, Anthony Gunstone, Timothy Hall, Wasim Hanif, Alan Jackson, Andrew Johnson, Franklin Joseph, Singhan Krishnan, Mick Kumwenda, Iain MacDougall, Paul Nixon, Joseph O'Hare, Sam Philip, Shenaz Ramtoola, Manish Saxena, Davesh Sennik, Godwin Simon, Baldev Singh, Jeffrey Stephens, Anna Strzelecka, Rehan Symonds, Wayne Turner, Mona Wahba, John Wakeling, David Wheeler, Peter Winocour, Joseph Abdallah, Raied Abdullah, Matthew Abramowitz, Idalia Acosta, Joseph Aiello, Laura Akright, Ayim Akyea-Djamson, Rajendran Alappan, Radica Alicic, Amer Al-Karadsheh, Dale Crawford Allison, Carlos Arauz-Pacheco, Shahabul Arfeen, Ahmed Arif, Moogali Arvind, Naveen Atray, Ahmed Awad, Peggy Barnhill, Elizabeth Barranco, Carlos Barrera, Matthew Beacom, Venkata Behara, Diogo Belo, Rhonda Bentley-Lewis, Ramon Berenguer, Lidia Bermudez, Marializa Bernardo, Mihaela Biscoveanu, Cynthia Bowman-Stroud, Donald Brandon, Osvaldo Brusco, Robert Busch, Yamil Canaan, Alicia Chilito, Tom Christensen, Cynthia Christiano, Elena Christofides, Caroucel Chuateco, Kenneth Cohen, Robert Cohen, Debbie Cohen-Stein, Charles Cook, Daniel Coyne, Nizar Daboul, Riad Darwish, Adarsh Daswani, Kenneth Deck, Cyrus Desouza, Devasmita Dev, Monika Dhillon, Sohan Dua, Frank Eder, Ana Maria Elosegui, Mohamed El-Shahawy, John Ervin, Alberto Esquenazi, John Evans, Steven Fishbane, Juan Frias, Eugenia Galindo-Ramos, Claude Galphin, Adline Ghazi, Enrique Gonzalez, David Gorson, Anupama Gowda, Barbara Greco, Stephen Grubb, Rakesh Gulati, Jamal Hammoud, Stuart Handelsman, Israel Hartman, Kenneth Hershon, Daniel Hiser, George Hon, Radu Jacob, Maria Jaime, Aamir Jamal, Charles Kaupke, Gerald Keightley, Elizabeth Kern, Rakhi Khanna, Zeid Khitan, Sun Kim, Nelson Kopyt, Csaba Kovesdy, Gopal Krishna, Jeffrey (Jay) Kropp, Amrendra Kumar, Jayant Kumar, Neil Kumar, Jorge Kusnir, Wendy Lane, Mary Lawrence, Lawrence Lehrner, John Lentz, Dennis Levinson, Derek Lewis, Kenneth Liss, Andreas Maddux, Hiralal Maheshwari, Sreedhar Mandayam, Isam Marar, Bhasker Mehta, John Middleton, Jorge Mordujovich, Ramon Moreda, Moustafa Moustafa, Samuel Mujica Trenche, Mohanram Narayanan, Javier Narvarte, Tareq Nassar, George Newman, Brian Nichol, Philip Nicol, Josier Nisnisan, A. Kaldun Nossuli, Chamberlain Obialo, Sarah Olelewe, Michael Oliver, Andrew O'Shaughnessy, John Padron, Rohit Pankhaniya, Reginald Parker, Devesh Patel, Gnyandev Patel, Nina Patel, Humberto Pavon, Armando Perez, Carlos Perez, Alan Perlman, Karlton Pettis, Walter Pharr, Andrea Phillips, Raman Purighalla, Luis Quesada-Suarez, Rajiv Ranjan, Sanjeev Rastogi, Jakkidi Reddy, Marc Rendell, Lisa Rich, Michael Robinson, Hector Rodriguez, Sylvia Rosas, Fadi Saba, Rallabhandi Sankaram, Ravi Sarin, Robert Schreiman, David Scott, Mohamed Sekkarie, John Sensenbrenner, Muhammad Shakeel, Michael Shanik, Sylvia Shaw, Stephen Smith, Richard Solomon, Amy Sprague, Leslie Spry, Pusadee Suchinda, Senan Sultan, Prasanth Surampudi, Sherry Sussman, Anjanette Tan, Antonio Terrelonge, Michael Thompson, Fernando Trespalacios, Bruce Trippe, Pilar Trueba, Marcel Twahirwa, John Updegrove, Peter Van Buren, Mark Vannorsdall, Freemu Varghese, Pedro Velasquez-Mieyer, Sailaja Ventrapragada, Goga Vukotic, Khurram Wadud, Mark Warren, Henry Watson, Ronald Watts, Daniel Weiner, James Welker, Jean Welsh, Shelley Williams, and Michelle Zaniewski-Singh

Subjects
age, diabetes, Nephrology, kidney outcomes, sex, Diabetic kidney disease, canagliflozin, cardiovascular outcomes, chronic kidney disease, sodium/glucose cotransporter 2 inhibitors
Abstract

Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kidney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a randomized controlled trial.Setting & Participants: Participants in the CREDENCE trial.Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kidney failure, doubling of serum creatinine concentration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Outcomes were evaluated by age at baseline (Results: The mean age of the cohort was 63.0 ± 9.2 years, and 34% were female. Older age and female sex were independently associated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (a composite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.48-0.82], and 0.89 [0.61-1.29] for ages Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791.

Published
2023
Full Text
View/download PDF

99. Minn. Court of Appeals: Fragale v. Leeds United, L.L.C

Subjects
Attorneys, Law
Abstract

Discovery; Attorney Fees Where defendants did not respond to plaintiff's discovery requests within the time permitted by the Rules of Civil Procedure; plaintiff acted in good faith to secure the [...]

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results