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55. Variants in ZNF365 isoform D are associated with Crohnʼs disease

Author

Haritunians, Talin, Jones, Michelle R, McGovern, Dermot P B, Shih, David Q, Barrett, Robert J, Derkowski, Carrie, Dubinsky, Marla C, Dutridge, Debra, Fleshner, Phillip R, Ippoliti, Andrew, King, Lily, Leshinsky-Silver, Esther, Levine, Arie, Melmed, Gil Y, Mengesha, Emebet, Vasilauskas, Eric A, Ziaee, Shabnam, Rotter, Jerome I, Targan, Stephan R, and Taylor, Kent D

Published
2011
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56. Management of Patients With Crohn’s Disease and Ulcerative Colitis During the Coronavirus Disease-2019 Pandemic: Results of an International Meeting

Author

Rubin, David T., primary, Abreu, Maria T., additional, Rai, Victoria, additional, Siegel, Corey A., additional, Ahuja, Vineet, additional, Allez, Matthieu, additional, Ananthakrishnan, Ashwin N., additional, Bernstein, Charles N., additional, Braun, Jonathan G., additional, Chowers, Yehuda, additional, Colombel, Jean-Frederic, additional, Danese, Silvio, additional, D'Haens, Geert, additional, D'Hoore, Andre, additional, Dignass, Axel, additional, Dotan, Iris, additional, Dubinsky, Marla C., additional, Ekbom, Anders, additional, Fleshner, Phillip R., additional, Gassull, Miquel A., additional, Gearry, Richard B., additional, Ghosh, Subrata, additional, Griffiths, Anne M., additional, Halfvarson, Jonas, additional, Hanauer, Stephen B., additional, Harpaz, Noam, additional, Hart, Ailsa, additional, Kamm, Michael A., additional, Kaplan, Gil G., additional, Koutroubakis, Ioannis, additional, Lakatos, Peter L., additional, Levine, Arie, additional, Lewis, James D., additional, Lindsay, James O., additional, Loftus, Edward V., additional, Louis, Edouard, additional, Lukas, Milan, additional, Magro, Fernando, additional, Mahadevan, Uma, additional, Mantzaris, Gerasimos J., additional, McGovern, Dermot P., additional, Moum, Bjørn A., additional, Munkholm, Pia, additional, Neurath, Markus F., additional, Ng, Siew C., additional, O'Morain, Colm, additional, Panaccione, Remo, additional, Panes, Julian, additional, Peyrin-Biroulet, Laurent, additional, Prantera, Cosimo, additional, Ran, Zhihua, additional, Reinisch, Walter, additional, Remzi, Feza H., additional, Sachar, David B., additional, Sandborn, William J., additional, Sartor, R. Balfour, additional, Schölmerich, Jürgen, additional, Schreiber, Stefan, additional, Siegmund, Britta, additional, Silverberg, Mark S., additional, Söderholm, Johan D., additional, Stange, Eduard F., additional, Steinwurz, Flavio, additional, Turner, Dan, additional, Vatn, Morten H., additional, Vermeire, Severine, additional, Brenner, Erica J., additional, Christensen, Britt, additional, D'Amico, Ferdinando, additional, Griffiths, Chris M., additional, Higgins, Peter D., additional, Kappelman, Michael D., additional, Lees, Charlie, additional, Regueiro, Miguel D., additional, Rosh, Joel R., additional, and Ungaro, Ryan, additional

Published
2020
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61. Selected abstracts

Author

Rothenberger, David A., Senagore, Anthony, Fleshner, Phillip R., Blatchford, J., McIntyre, P. Bernard, Ambroze, Jr., Wayne L., Oliver, Gregory C., and Blatchford, Garnet J.

Published
1996
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65. Selected abstracts

Author

Wexner, Steven D., Roberts, Patricia L., Welling, David R., Rothenberger, David A., and Fleshner, Phillip R.

Published
1994
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66. Selected abstracts

Author

Vasilevsky, Carol-Ann, Rothenberger, David A., Nelson, Heidi, Fleshner, Phillip R., Welling, David R., Fleshman, James W., and Wexner, Steven D.

Published
1993
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67. Selected abstracts

Author

Wexner, Steven D., Fleshner, Phillip R., Vasilevsky, Carol-ann, Nelson, Heidi M., and Roberts, Patricia L.

Published
1993
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72. Pre-pouch Ileitis is Associated with Development of Crohn's Disease-like Complications and Pouch Failure.

Author

Syal, Gaurav, Shemtov, Ron, Bonthala, Nirupama, Vasiliauskas, Eric A, Feldman, Edward J, Zaghiyan, Karen, Ha, Christina Y, McGovern, Dermot P B, Targan, Stephan R, Melmed, Gil Y, and Fleshner, Phillip R

Abstract

Background and Aims It is unclear whether pre-pouch ileitis heralds an aggressive inflammatory pouch disease in patients with ileal pouch-anal anastomosis [IPAA]. We compared outcomes of patients with pouchitis and concomitant pre-pouch ileitis with those with pouchitis alone. Methods Patients undergoing IPAA surgery for inflammatory bowel disease, who subsequently developed pouchitis with concomitant pre-pouch ileitis [pre-pouch ileitis group], were matched by year of IPAA surgery and preoperative diagnosis [ulcerative colitis or inflammatory bowel disease-unclassified] with patients who developed pouchitis alone [pouchitis group]. Primary outcomes were development of Crohn's disease [CD]-like complications [non-anastomotic strictures or perianal disease >6 months after ileostomy closure] and pouch failure. Secondary outcomes were need for surgical/endoscopic interventions and immunosuppressive therapy. Log-rank testing was used to compare outcome-free survival, and Cox regression was performed to identify predictors of outcomes. Results There were 66 patients in each group. CD-like complications and pouch failure developed in 36.4% and 7.6% patients in the pre-pouch ileitis group and 10.6% and 1.5% in pouchitis group, respectively. CD-like complications-free survival [log-rank p = 0.0002] and pouch failure-free survival [log-rank p = 0.046] were significantly lower in the pre-pouch ileitis group. The pre-pouch ileitis group had a higher risk of requiring surgical/endoscopic interventions [log-rank p = 0.0005] and immunosuppressive therapy [log-rank p <0.0001]. Pre-pouch ileitis was independently associated with an increased risk of CD-like complications (hazard ratio [HR] 3.8; p = 0.0007), need for surgical/endoscopic interventions [HR 4.1; p = 0.002], and immunosuppressive therapy [HR 5.0; p = 0.0002]. Conclusions Pre-pouch ileitis is associated with a higher risk of complicated disease and pouch failure than pouchitis. It should be considered a feature of CD. [ABSTRACT FROM AUTHOR]

Published
2021
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75. In Brief

Author

Mahmoud, Najjia N., Halwani, Yasmin, Montbrun, Sandra de, Shah, Puja M., Hedrick, Traci L., Rashid, Farzana, Schwartz, David A., Dalal, Robin L., Kamiński, Jan P., Zaghiyan, Karen, Fleshner, Phillip R., Weissler, Jason M., and Fischer, John P.

Published
2017
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76. A 27-year experience with splenectomy for Gaucher's disease

Author

Fleshner, Phillip R., Aufses, Arthur H., Jr., Grabowski, Gregory A., and Elias, Richard

Subjects
Splenectomy -- Evaluation, Splenectomy -- Complications, Gaucher's disease -- Care and treatment, Splenectomy -- Methods, Health
Abstract

Gaucher's disease is an inherited metabolic condition that causes massive enlargement of the spleen. The accepted treatment is surgical removal of the entire spleen. Because of the risk of fatal infection and the potential for bone and liver disease after splenectomy, partial splenectomy is considered preferable by some surgeons. A retrospective study was undertaken of patients undergoing splenectomy for Gaucher's disease over the past 27 years. The records of 48 patients were reviewed to determine both the short and long-term results of treatment. Total splenectomy was performed on 35 patients (73 percent), and partial splenectomy on 13 patients (27 percent). There was one death following surgery; this patient had undergone total splenectomy. Thirteen patients had postoperative complications. Within an average follow-up period of 25 months, 11 patients (23 percent) who had undergone total splenectomy showed accelerated bone disease. None of the partial splenectomy patients had evidence of accelerated bone disease. Since surgery, eight patients have died; four deaths were from malignancies that occurred after total splenectomy. These findings indicate that both total and partial splenectomy can be performed safely with minimal increased illness. Total splenectomy is associated with more aggressive bone disease and a tendency to develop malignancy. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

80. A randomized, blinded, multicenter trial of a gentamicin vancomycin gel (DFA-02) in patients undergoing abdominal surgery

Author

Bennett-Guerrero, Elliott, primary, Berry, Scott M., additional, Bergese, Sergio D., additional, Fleshner, Phillip R., additional, Minkowitz, Harold S., additional, Segura-Vasi, Alvaro M., additional, Itani, Kamal M.F., additional, Henderson, Karen W., additional, Rackowski, Felicia P., additional, Aberle, Laura H., additional, Stryjewski, Martin E., additional, Corey, G. Ralph, additional, and Allenby, Kent S., additional

Published
2017
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85. Genome-wide association identifies multiple ulcerative colitis susceptibility loci (vol 42, pg 332, 2010)

Author

McGovern, Dermot P. B., Gardet, Agnes, Törkvist, Leif, Goyette, Philippe, Essers, Jonah, Taylor, Kent D., Neale, Benjamin M., Ong, Rick T. H., Lagace, Caroline, Li, Chun, Green, Todd, Stevens, Christine R., Beauchamp, Claudine, Fleshner, Phillip R., Carlson, Marie, D'Amato, Mauro, Halfvarson, Jonas, Hibberd, Martin L., Loerdal, Mikael, Padyukov, Leonid, Andriulli, Angelo, Colombo, Elisabetta, Latiano, Anna, Palmieri, Orazio, Bernard, Edmond-Jean, Deslandres, Colette, Hommes, Daan W., de Jong, Dirk J., Stokkers, Pieter C., Weersma, Rinse K., Sharma, Yashoda, Silverberg, Mark S., Cho, Judy H., Wu, Jing, Roeder, Kathryn, Brant, Steven R., Schumm, L. Phillip, Duerr, Richard H., Dubinsky, Marla C., Glazer, Nicole L., Haritunians, Talin, Ippoliti, Andy, Melmed, Gil Y., Siscovick, David S., Vasiliauskas, Eric A., Targan, Stephan R., Annese, Vito, Wijmenga, Cisca, Pettersson, Sven, Rotter, Jerome I., Xavier, Ramnik J., Daly, Mark J., Rioux, John D., Seielstad, Mark, McGovern, Dermot P. B., Gardet, Agnes, Törkvist, Leif, Goyette, Philippe, Essers, Jonah, Taylor, Kent D., Neale, Benjamin M., Ong, Rick T. H., Lagace, Caroline, Li, Chun, Green, Todd, Stevens, Christine R., Beauchamp, Claudine, Fleshner, Phillip R., Carlson, Marie, D'Amato, Mauro, Halfvarson, Jonas, Hibberd, Martin L., Loerdal, Mikael, Padyukov, Leonid, Andriulli, Angelo, Colombo, Elisabetta, Latiano, Anna, Palmieri, Orazio, Bernard, Edmond-Jean, Deslandres, Colette, Hommes, Daan W., de Jong, Dirk J., Stokkers, Pieter C., Weersma, Rinse K., Sharma, Yashoda, Silverberg, Mark S., Cho, Judy H., Wu, Jing, Roeder, Kathryn, Brant, Steven R., Schumm, L. Phillip, Duerr, Richard H., Dubinsky, Marla C., Glazer, Nicole L., Haritunians, Talin, Ippoliti, Andy, Melmed, Gil Y., Siscovick, David S., Vasiliauskas, Eric A., Targan, Stephan R., Annese, Vito, Wijmenga, Cisca, Pettersson, Sven, Rotter, Jerome I., Xavier, Ramnik J., Daly, Mark J., Rioux, John D., and Seielstad, Mark

Published
2011
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86. Genome-wide association identifies multiple ulcerative colitis susceptibility loci

Author

McGovern, Dermot P. B., Gardet, Agnes, Torkvist, Leif, Goyette, Philippe, Essers, Jonah, Taylor, Kent D., Neale, Benjamin M., Ong, Rick T. H., Lagace, Caroline, Li, Chun, Green, Todd, Stevens, Christine R., Beauchamp, Claudine, Fleshner, Phillip R., Carlson, Marie, D'Amato, Mauro, Halfvarson, Jonas, Hibberd, Martin L., Lordal, Mikael, Padyukov, Leonid, Andriulli, Angelo, Colombo, Elisabetta, Latiano, Anna, Palmieri, Orazio, Bernard, Edmond-Jean, Deslandres, Colette, Hommes, Daan W., de Jong, Dirk J., Stokkers, Pieter C., Weersma, Rinse K., Sharma, Yashoda, Silverberg, Mark S., Cho, Judy H., Wu, Jing, Roeder, Kathryn, Brant, Steven R., Schumm, L. Phillip, Duerr, Richard H., Dubinsky, Marla C., Glazer, Nicole L., Haritunians, Talin, Ippoliti, Andy, Melmed, Gil Y., Siscovick, David S., Vasiliauskas, Eric A., Targan, Stephan R., Annese, Vito, Wijmenga, Cisca, Pettersson, Sven, Rotter, Jerome I., Xavier, Ramnik J., Daly, Mark J., Rioux, John D., Seielstad, Mark, McGovern, Dermot P. B., Gardet, Agnes, Torkvist, Leif, Goyette, Philippe, Essers, Jonah, Taylor, Kent D., Neale, Benjamin M., Ong, Rick T. H., Lagace, Caroline, Li, Chun, Green, Todd, Stevens, Christine R., Beauchamp, Claudine, Fleshner, Phillip R., Carlson, Marie, D'Amato, Mauro, Halfvarson, Jonas, Hibberd, Martin L., Lordal, Mikael, Padyukov, Leonid, Andriulli, Angelo, Colombo, Elisabetta, Latiano, Anna, Palmieri, Orazio, Bernard, Edmond-Jean, Deslandres, Colette, Hommes, Daan W., de Jong, Dirk J., Stokkers, Pieter C., Weersma, Rinse K., Sharma, Yashoda, Silverberg, Mark S., Cho, Judy H., Wu, Jing, Roeder, Kathryn, Brant, Steven R., Schumm, L. Phillip, Duerr, Richard H., Dubinsky, Marla C., Glazer, Nicole L., Haritunians, Talin, Ippoliti, Andy, Melmed, Gil Y., Siscovick, David S., Vasiliauskas, Eric A., Targan, Stephan R., Annese, Vito, Wijmenga, Cisca, Pettersson, Sven, Rotter, Jerome I., Xavier, Ramnik J., Daly, Mark J., Rioux, John D., and Seielstad, Mark

Abstract

Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan(1), comprising, in aggregate, 2,693 individuals with ulcerative colitis and 6,791 control subjects. Fifty-nine SNPs from 14 independent loci attained an association significance of P < 10(-5). Seven of these loci exceeded genome-wide significance (P < 5 x 10(-8)). After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3). We confirmed association with 14 previously identified ulcerative colitis susceptibility loci, and an analysis of acknowledged Crohn's disease loci showed that roughly half of the known Crohn's disease associations are shared with ulcerative colitis. These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis.

Published
2010
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90. Genetic predictors of medically refractory ulcerative colitis

Author

Haritunians, Talin, primary, Taylor, Kent D., additional, Targan, Stephan R., additional, Dubinsky, Marla, additional, Ippoliti, Andrew, additional, Kwon, Soonil, additional, Guo, Xiuqing, additional, Melmed, Gil Y., additional, Berel, Dror, additional, Mengesha, Emebet, additional, Psaty, Bruce M., additional, Glazer, Nicole L., additional, Vasiliauskas, Eric A., additional, Rotter, Jerome I., additional, Fleshner, Phillip R., additional, and McGovern, Dermot P.B., additional

Published
2010
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93. Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer

Author

deVos, Theo, primary, Tetzner, Reimo, primary, Model, Fabian, primary, Weiss, Gunter, primary, Schuster, Matthias, primary, Distler, Jürgen, primary, Steiger, Kathryn V, primary, Grützmann, Robert, primary, Pilarsky, Christian, primary, Habermann, Jens K, primary, Fleshner, Phillip R, primary, Oubre, Benton M, primary, Day, Robert, primary, Sledziewski, Andrew Z, primary, and Lofton-Day, Catherine, primary

Published
2009
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98. Anti-flagellin (CBir1) phenotypic and genetic Crohnʼs disease associations

Author

Papadakis, Konstantinos A., primary, Yang, Huiying, additional, Ippoliti, Andrew, additional, Mei, Ling, additional, Elson, Charles O., additional, Hershberg, Robert M., additional, Vasiliauskas, Eric A., additional, Fleshner, Phillip R., additional, Abreu, Maria T., additional, Taylor, Kent, additional, Landers, Carol J., additional, Rotter, Jerome I., additional, and Targan, Stephan R., additional

Published
2007
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100. NOD2 Variants and Antibody Response to Microbial Antigens in Crohn’s Disease Patients and Their Unaffected Relatives

Author

Devlin, Shane M., primary, Yang, Huiying, additional, Ippoliti, Andrew, additional, Taylor, Kent D., additional, Landers, Carol J., additional, Su, Xiaowen, additional, Abreu, Maria T., additional, Papadakis, Konstantinos A., additional, Vasiliauskas, Eric A., additional, Melmed, Gil Y., additional, Fleshner, Phillip R., additional, Mei, Ling, additional, Rotter, Jerome I., additional, and Targan, Stephan R., additional

Published
2007
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