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57. Correction to “Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models”

Author

Finlay, M. Raymond V., primary, Anderton, Mark, additional, Bailey, Andrew, additional, Boyd, Scott, additional, Brookfield, Joanna, additional, Cairnduff, Ceri, additional, Charles, Mark, additional, Cheasty, Anne, additional, Critchlow, Susan E., additional, Culshaw, Janet, additional, Debreczeni, Judit, additional, Ekwuru, Tennyson, additional, Hollingsworth, Ian, additional, Jones, Neil, additional, Leroux, Fred, additional, Littleson, Mairi, additional, McCarron, Hollie, additional, McKelvie, Jennifer, additional, Mooney, Lorraine, additional, Nissink, J. Willem M., additional, Patel, Joe, additional, Perkins, David, additional, Powell, Steve, additional, Quesada, Mar Jimenez, additional, Raubo, Piotr, additional, Sabin, Verity, additional, Smith, James, additional, Smith, Peter D., additional, Stark, Andrew, additional, Ting, Attilla, additional, Wang, Peng, additional, Wilson, Zena, additional, Winter-Holt, Jon J., additional, Wood, J. Matthew, additional, Wrigley, Gail L., additional, Yu, Guoqing, additional, and Zhang, Peng, additional

Published
2023
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60. Constant 4He Concentration and 190Pt‐4He age of Detrital Pt‐Alloy Grains from the Santiago River, Ecuador: Potential as a 4He Mineral Reference Material.

Author

Yakubovich, Olga V., Stuart, Finlay M., Ivanova, Ekaterina S., and Gervilla, Fernando

Subjects
*REFERENCE sources, *ENVIRONMENTAL research, *GAS well drilling, *MINERALS, *GAS extraction, *PLATINUM
Abstract

Over the last few decades geo‐ and thermochronological techniques based on the accumulation of radiogenic 4He in minerals have gained popularity. Currently there is no mineral‐based 4He reference material that allows routine screening of gas extraction and measurement procedures. The commonly‐used mineral reference material for (U‐Th)/He thermochronology have variable U and Th contents which result in variable 4He concentrations. Here we demonstrate that native platinum grains (RS‐Pt) from placer deposits in the Santiago River, Ecuador, yield constant 4He contents and may be used as a reference material. Helium concentrations measured at the Scottish Universities Environmental Research Centre (n = 8) and Institute of Precambrian Geology and Geochronology RAS (n = 9) noble gas laboratories yield mean 4He concentrations that overlap at the 95% confidence level. The weighted mean 4He concentration is 215 ± 4 × 1011 at g‐1 (2s) and mean 190Pt‐4He age is 39.6 ± 0.7 Ma (2s). Samples of the Santiago River Pt concentrate are available on request from the SUERC laboratory. [ABSTRACT FROM AUTHOR]

Published
2023
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65. Supplementary Figure 1 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, primary, Hernandez, Marylens, primary, Srinivasan, Srimathi, primary, Tentarelli, Sharon, primary, Griffin, Matthew, primary, Wang, Yanjun, primary, Pop-Damkov, Petar, primary, Prickett, Laura B., primary, Kankkonen, Cecilia, primary, Shen, Minhui, primary, Martin, Maryann San, primary, Wu, Song, primary, Castaldi, M. Paola, primary, Ghadially, Hormas, primary, Varnes, Jeffrey, primary, Gales, Sonya, primary, Henry, David, primary, Hoover, Clare, primary, Mele, Deanna A., primary, Simpson, Iain, primary, Gangl, Eric T., primary, Mlynarski, Scott N., primary, Finlay, M. Raymond V., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Shao, Wenlin, primary, and Schuller, Alwin G., primary

Published
2023
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66. Supplementary Table 1 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, primary, Hernandez, Marylens, primary, Srinivasan, Srimathi, primary, Tentarelli, Sharon, primary, Griffin, Matthew, primary, Wang, Yanjun, primary, Pop-Damkov, Petar, primary, Prickett, Laura B., primary, Kankkonen, Cecilia, primary, Shen, Minhui, primary, Martin, Maryann San, primary, Wu, Song, primary, Castaldi, M. Paola, primary, Ghadially, Hormas, primary, Varnes, Jeffrey, primary, Gales, Sonya, primary, Henry, David, primary, Hoover, Clare, primary, Mele, Deanna A., primary, Simpson, Iain, primary, Gangl, Eric T., primary, Mlynarski, Scott N., primary, Finlay, M. Raymond V., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Shao, Wenlin, primary, and Schuller, Alwin G., primary

Published
2023
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67. Supplementary Figure 3 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, primary, Hernandez, Marylens, primary, Srinivasan, Srimathi, primary, Tentarelli, Sharon, primary, Griffin, Matthew, primary, Wang, Yanjun, primary, Pop-Damkov, Petar, primary, Prickett, Laura B., primary, Kankkonen, Cecilia, primary, Shen, Minhui, primary, Martin, Maryann San, primary, Wu, Song, primary, Castaldi, M. Paola, primary, Ghadially, Hormas, primary, Varnes, Jeffrey, primary, Gales, Sonya, primary, Henry, David, primary, Hoover, Clare, primary, Mele, Deanna A., primary, Simpson, Iain, primary, Gangl, Eric T., primary, Mlynarski, Scott N., primary, Finlay, M. Raymond V., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Shao, Wenlin, primary, and Schuller, Alwin G., primary

Published
2023
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68. Supplementary Figure 4 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, primary, Hernandez, Marylens, primary, Srinivasan, Srimathi, primary, Tentarelli, Sharon, primary, Griffin, Matthew, primary, Wang, Yanjun, primary, Pop-Damkov, Petar, primary, Prickett, Laura B., primary, Kankkonen, Cecilia, primary, Shen, Minhui, primary, Martin, Maryann San, primary, Wu, Song, primary, Castaldi, M. Paola, primary, Ghadially, Hormas, primary, Varnes, Jeffrey, primary, Gales, Sonya, primary, Henry, David, primary, Hoover, Clare, primary, Mele, Deanna A., primary, Simpson, Iain, primary, Gangl, Eric T., primary, Mlynarski, Scott N., primary, Finlay, M. Raymond V., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Shao, Wenlin, primary, and Schuller, Alwin G., primary

Published
2023
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69. Supplementary Figure 5 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, primary, Hernandez, Marylens, primary, Srinivasan, Srimathi, primary, Tentarelli, Sharon, primary, Griffin, Matthew, primary, Wang, Yanjun, primary, Pop-Damkov, Petar, primary, Prickett, Laura B., primary, Kankkonen, Cecilia, primary, Shen, Minhui, primary, Martin, Maryann San, primary, Wu, Song, primary, Castaldi, M. Paola, primary, Ghadially, Hormas, primary, Varnes, Jeffrey, primary, Gales, Sonya, primary, Henry, David, primary, Hoover, Clare, primary, Mele, Deanna A., primary, Simpson, Iain, primary, Gangl, Eric T., primary, Mlynarski, Scott N., primary, Finlay, M. Raymond V., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Shao, Wenlin, primary, and Schuller, Alwin G., primary

Published
2023
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70. Supplementary Figure 2 from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, primary, Hernandez, Marylens, primary, Srinivasan, Srimathi, primary, Tentarelli, Sharon, primary, Griffin, Matthew, primary, Wang, Yanjun, primary, Pop-Damkov, Petar, primary, Prickett, Laura B., primary, Kankkonen, Cecilia, primary, Shen, Minhui, primary, Martin, Maryann San, primary, Wu, Song, primary, Castaldi, M. Paola, primary, Ghadially, Hormas, primary, Varnes, Jeffrey, primary, Gales, Sonya, primary, Henry, David, primary, Hoover, Clare, primary, Mele, Deanna A., primary, Simpson, Iain, primary, Gangl, Eric T., primary, Mlynarski, Scott N., primary, Finlay, M. Raymond V., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Shao, Wenlin, primary, and Schuller, Alwin G., primary

Published
2023
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71. Data from Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, primary, Hernandez, Marylens, primary, Srinivasan, Srimathi, primary, Tentarelli, Sharon, primary, Griffin, Matthew, primary, Wang, Yanjun, primary, Pop-Damkov, Petar, primary, Prickett, Laura B., primary, Kankkonen, Cecilia, primary, Shen, Minhui, primary, Martin, Maryann San, primary, Wu, Song, primary, Castaldi, M. Paola, primary, Ghadially, Hormas, primary, Varnes, Jeffrey, primary, Gales, Sonya, primary, Henry, David, primary, Hoover, Clare, primary, Mele, Deanna A., primary, Simpson, Iain, primary, Gangl, Eric T., primary, Mlynarski, Scott N., primary, Finlay, M. Raymond V., primary, Drew, Lisa, primary, Fawell, Stephen E., primary, Shao, Wenlin, primary, and Schuller, Alwin G., primary

Published
2023
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72. Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners

Author

Doshi, Aatman S., primary, Cantin, Susan, additional, Hernandez, Marylens, additional, Srinivasan, Srimathi, additional, Tentarelli, Sharon, additional, Griffin, Matthew, additional, Wang, Yanjun, additional, Pop-Damkov, Petar, additional, Prickett, Laura B., additional, Kankkonen, Cecilia, additional, Shen, Minhui, additional, Martin, Maryann San, additional, Wu, Song, additional, Castaldi, M. Paola, additional, Ghadially, Hormas, additional, Varnes, Jeffrey, additional, Gales, Sonya, additional, Henry, David, additional, Hoover, Clare, additional, Mele, Deanna A., additional, Simpson, Iain, additional, Gangl, Eric T., additional, Mlynarski, Scott N., additional, Finlay, M. Raymond V., additional, Drew, Lisa, additional, Fawell, Stephen E., additional, Shao, Wenlin, additional, and Schuller, Alwin G., additional

Published
2023
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73. Supplementary Figure 3 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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74. Data from Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Author

Floc'h, Nicolas, primary, Martin, Matthew J., primary, Riess, Jonathan W., primary, Orme, Jonathan P., primary, Staniszewska, Anna D., primary, Ménard, Ludovic, primary, Cuomo, Maria Emanuela, primary, O'Neill, Daniel J., primary, Ward, Richard A., primary, Finlay, M. Raymond V., primary, McKerrecher, Darren, primary, Cheng, Mingshan, primary, Vang, Daniel P., primary, Burich, Rebekah A., primary, Keck, James G., primary, Gandara, David R., primary, Mack, Philip C., primary, and Cross, Darren A.E., primary

Published
2023
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75. Supplementary Table 1 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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76. Supplementary Figure 1 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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77. Supplementary Figures 1-8 from Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Author

Floc'h, Nicolas, primary, Martin, Matthew J., primary, Riess, Jonathan W., primary, Orme, Jonathan P., primary, Staniszewska, Anna D., primary, Ménard, Ludovic, primary, Cuomo, Maria Emanuela, primary, O'Neill, Daniel J., primary, Ward, Richard A., primary, Finlay, M. Raymond V., primary, McKerrecher, Darren, primary, Cheng, Mingshan, primary, Vang, Daniel P., primary, Burich, Rebekah A., primary, Keck, James G., primary, Gandara, David R., primary, Mack, Philip C., primary, and Cross, Darren A.E., primary

Published
2023
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78. Supplementary Figure 7 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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79. Supplementary Figure 4 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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80. Supplementary Figure 5 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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81. Supplementary Figure 6 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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82. Supplementary Figure 2 from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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83. Data from AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Author

Cross, Darren A.E., primary, Ashton, Susan E., primary, Ghiorghiu, Serban, primary, Eberlein, Cath, primary, Nebhan, Caroline A., primary, Spitzler, Paula J., primary, Orme, Jonathon P., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Mellor, Martine J., primary, Hughes, Gareth, primary, Rahi, Amar, primary, Jacobs, Vivien N., primary, Brewer, Monica Red, primary, Ichihara, Eiki, primary, Sun, Jing, primary, Jin, Hailing, primary, Ballard, Peter, primary, Al-Kadhimi, Katherine, primary, Rowlinson, Rachel, primary, Klinowska, Teresa, primary, Richmond, Graham H.P., primary, Cantarini, Mireille, primary, Kim, Dong-Wan, primary, Ranson, Malcolm R., primary, and Pao, William, primary

Published
2023
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84. Supplementary Data from Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs

Author

Colclough, Nicola, primary, Chen, Kan, primary, Johnström, Peter, primary, Strittmatter, Nicole, primary, Yan, Yumei, primary, Wrigley, Gail L., primary, Schou, Magnus, primary, Goodwin, Richard, primary, Varnäs, Katarina, primary, Adua, Sally J., primary, Zhao, Minghui, primary, Nguyen, Don X., primary, Maglennon, Gareth, primary, Barton, Peter, primary, Atkinson, James, primary, Zhang, Lin, primary, Janefeldt, Annika, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Takano, Akihiro, primary, Arakawa, Ryosuke, primary, Kondrashov, Mikhail, primary, Malmquist, Jonas, primary, Revunov, Evgeny, primary, Vazquez-Romero, Ana, primary, Moein, Mohammad Mahdi, primary, Windhorst, Albert D., primary, Karp, Natasha A., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Yates, James W.T., primary, Smith, Paul D., primary, Farde, Lars, primary, Cheng, Zack, primary, and Cross, Darren A.E., primary

Published
2023
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85. Figure S1 from Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs

Author

Colclough, Nicola, primary, Chen, Kan, primary, Johnström, Peter, primary, Strittmatter, Nicole, primary, Yan, Yumei, primary, Wrigley, Gail L., primary, Schou, Magnus, primary, Goodwin, Richard, primary, Varnäs, Katarina, primary, Adua, Sally J., primary, Zhao, Minghui, primary, Nguyen, Don X., primary, Maglennon, Gareth, primary, Barton, Peter, primary, Atkinson, James, primary, Zhang, Lin, primary, Janefeldt, Annika, primary, Wilson, Joanne, primary, Smith, Aaron, primary, Takano, Akihiro, primary, Arakawa, Ryosuke, primary, Kondrashov, Mikhail, primary, Malmquist, Jonas, primary, Revunov, Evgeny, primary, Vazquez-Romero, Ana, primary, Moein, Mohammad Mahdi, primary, Windhorst, Albert D., primary, Karp, Natasha A., primary, Finlay, M. Raymond V., primary, Ward, Richard A., primary, Yates, James W.T., primary, Smith, Paul D., primary, Farde, Lars, primary, Cheng, Zack, primary, and Cross, Darren A.E., primary

Published
2023
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86. A topographic hinge-zone divides coastal and inland ice dynamic regimes in East Antarctica

Author

Lund Andersen, Jane, Newall, Jennifer C., Fredin, Ola, Glasser, Neil F., Lifton, Nathaniel A., Stuart, Finlay M., Fabel, Derek, Caffee, Marc, Pedersen, Vivi K., Koester, Alexandria J., Suganuma, Yusuke, Harbor, Jonathan M., Stroeven, Arjen P., Lund Andersen, Jane, Newall, Jennifer C., Fredin, Ola, Glasser, Neil F., Lifton, Nathaniel A., Stuart, Finlay M., Fabel, Derek, Caffee, Marc, Pedersen, Vivi K., Koester, Alexandria J., Suganuma, Yusuke, Harbor, Jonathan M., and Stroeven, Arjen P.

Abstract

The impact of late Cenozoic climate on the East Antarctic Ice Sheet is uncertain. Poorly constrained patterns of relative ice thinning and thickening impair the reconstruction of past ice-sheet dynamics and global sea-level budgets. Here we quantify long-term ice cover of mountains protruding the ice-sheet surface in western Dronning Maud Land, using cosmogenic Chlorine-36, Aluminium-26, Beryllium-10, and Neon-21 from bedrock in an inverse modeling approach. We find that near-coastal sites experienced ice burial up to 75–97% of time since 1 Ma, while interior sites only experienced brief periods of ice burial, generally <20% of time since 1 Ma. Based on these results, we suggest that the escarpment in Dronning Maud Land acts as a hinge-zone, where ice-dynamic changes driven by grounding-line migration are attenuated inland from the coastal portions of the East Antarctic Ice Sheet, and where precipitation-controlled ice-thickness variations on the polar plateau taper off towards the coast.

Published
2023
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88. The total synthesis of the bicyclic acetal core of zaragozic acid C

Author

Finlay, M. R. V.

Subjects
547.7
Abstract

Zaragozic acid C 33 is a member of a family of naturally occurring, structurally complex fungal metabolites. These natural products are potent inhibitors of the enzyme squalene synthetase. All the zaragozic acids show a common, highly oxygenated 2,8-dioxobicyclo[3.2.1]octane "core" unit and differ only at the Cl alkyl and C6 acyl side chains. The first part of this thesis describes the synthesis of the model zaragozic acid bicyclic acetal core systems 171 and 172 (Scheme A) via acid catalysed cyclisation of the highly functionalised epoxides 158 and 148. The synthesis of the model cores was achieved in nine steps and good overall yield. Key steps include: (i) a highly diastereoselective anti, anti-aldol reaction between the ketone 112 and dienals 155 and 138; (ii) diastereo- and regioselective oxidation of the diene portion of 156-AA and 139-AA to provide the cyclisation precursors 158 and 148 and (iii) acid catalysed rearrangement of epoxides 158 and 148 under extremely mild conditions to provide the model zaragozic acid cores 171 and 172 in good yield. The second part of the dissertation describes synthetic studies directed towards the more highly functionalised model zaragozic acid bicyclic acetal core 187 (Scheme B). By exploiting the aldol chemistry of ketone 175, the correct oxygen functionally at C7 was established, and potential methods of introducing the C1 side chain were also explored. By use of the asymmetric diene oxidation methodology developed in the first part of the dissertation, the cyclisation precursor 211 was prepared. Upon treatment with catalytic acid, however, in contrast to the simpler cyclisation precursors 158 and 148, the epoxide 211 gave the kinetic acetal 213. Equilibration under acidic conditions did not deliver the desired model zaragozic acid bicyclic acetal core 187, but rather the isomeric acetal system 218. The final part of this thesis describes the synthesis of the C6 acyl side chain and the bicyclic acetal core of zaragozic acid C. The C1 side chain fragment 261 (Scheme C) was coupled to the bicyclic acetal core precursor 198 to provide the key diene fragment 276. Subsequent asymmetric stepwise oxidation of the diene portion of 276 provided the highly functionalised bicyclic acetal core precursors 279 and 282 which upon treatment with acid provided the zaragozic acid C bicyclic acetal core 249 with pendant C1 side chain.

Published
1997

89. The Winchcombe meteorite, a unique and pristine witness from the outer solar system

Author

King, Ashley J, Daly, Luke, Rowe, James, Joy, Katherine H, Greenwood, Richard C, Devillepoix, Hadrien AR, Suttle, Martin D, Chan, Queenie HS, Russell, Sara S, Bates, Helena C, Bryson, James FJ, Clay, Patricia L, Vida, Denis, Lee, Martin R, O'Brien, Áine, Hallis, Lydia J, Stephen, Natasha R, Tartèse, Romain, Sansom, Eleanor K, Towner, Martin C, Cupak, Martin, Shober, Patrick M, Bland, Phil A, Findlay, Ross, Franchi, Ian A, Verchovsky, Alexander B, Abernethy, Feargus AJ, Grady, Monica M, Floyd, Cameron J, Van Ginneken, Matthias, Bridges, John, Hicks, Leon J, Jones, Rhian H, Mitchell, Jennifer T, Genge, Matthew J, Jenkins, Laura, Martin, Pierre-Etienne, Sephton, Mark A, Watson, Jonathan S, Salge, Tobias, Shirley, Katherine A, Curtis, Rowan J, Warren, Tristram J, Bowles, Neil E, Stuart, Finlay M, Di Nicola, Luigia, Györe, Domokos, Boyce, Adrian J, Shaw, Kathryn MM, Elliott, Tim, Steele, Robert CJ, Povinec, Pavel, Laubenstein, Matthias, Sanderson, David, Cresswell, Alan, Jull, Anthony JT, Sýkora, Ivan, Sridhar, Sanjana, Harrison, Richard J, Willcocks, Francesca M, Harrison, Catherine S, Hallatt, Daniel, Wozniakiewicz, Penny J, Burchell, Mark J, Alesbrook, Luke S, Dignam, Aishling, Almeida, Natasha V, Smith, Caroline L, Clark, Brett, Humphreys-Williams, Emma R, Schofield, Paul F, Cornwell, Luke T, Spathis, Vassilia, Morgan, Geraint H, Perkins, Mark J, Kacerek, Richard, Campbell-Burns, Peter, Colas, Francois, Zanda, Brigitte, Vernazza, Pierre, Bouley, Sylvain, Jeanne, Simon, Hankey, Mike, Collins, Gareth S, Young, John S, Shaw, Clive, Horak, Jana, Jones, Dave, James, Nick, Bosley, Steve, Shuttleworth, Alan, Dickinson, Paul, McMullan, Ian, Robson, Derek, Smedley, Andrew RD, Stanley, Ben, Bassom, Richard, McIntyre, Mark, Suttle, Adam A, Fleet, Richard, Bastiaens, Luc, Ihász, Míra B, McMullan, Sarah, Boazman, Sarah J, Dickeson, Zach I, Grindrod, Peter M, Pickersgill, Annemarie E, Weir, Colin J, Suttle, Fiona M, Farrelly, Sarah, Spencer, Ieun, Naqvi, Sheeraz, Mayne, Ben, Skilton, Dan, Kirk, Dan, Mounsey, Ann, Mounsey, Sally E, Mounsey, Sarah, Godfrey, Pamela, Bond, Lachlan, Bond, Victoria, Wilcock, Cathryn, Wilcock, Hannah, Wilcock, Rob, King, Ashley J [0000-0001-6113-5417], Daly, Luke [0000-0002-7150-4092], Joy, Katherine H [0000-0003-4992-8750], Greenwood, Richard C [0000-0002-5544-8027], Devillepoix, Hadrien AR [0000-0001-9226-1870], Suttle, Martin D [0000-0001-7165-2215], Chan, Queenie HS [0000-0001-7205-8699], Russell, Sara S [0000-0001-5531-7847], Bates, Helena C [0000-0002-0469-9483], Bryson, James FJ [0000-0002-5675-8545], Vida, Denis [0000-0003-4166-8704], Lee, Martin R [0000-0002-6004-3622], O'Brien, Áine [0000-0002-2591-7902], Hallis, Lydia J [0000-0001-6455-8415], Stephen, Natasha R [0000-0003-3952-922X], Tartèse, Romain [0000-0002-3490-9875], Sansom, Eleanor K [0000-0003-2702-673X], Towner, Martin C [0000-0002-8240-4150], Cupak, Martin [0000-0003-2193-0867], Shober, Patrick M [0000-0003-4766-2098], Bland, Phil A [0000-0002-4681-7898], Findlay, Ross [0000-0001-7794-1819], Franchi, Ian A [0000-0003-4151-0480], Verchovsky, Alexander B [0000-0002-3532-5003], Abernethy, Feargus AJ [0000-0001-7210-3058], Grady, Monica M [0000-0002-4055-533X], Floyd, Cameron J [0000-0001-5986-491X], Van Ginneken, Matthias [0000-0002-2508-7021], Bridges, John [0000-0002-9579-5779], Hicks, Leon J [0000-0002-2464-0948], Jones, Rhian H [0000-0001-8238-9379], Mitchell, Jennifer T [0000-0002-5922-2463], Genge, Matthew J [0000-0002-9528-5971], Jenkins, Laura [0000-0003-0886-8667], Martin, Pierre-Etienne [0000-0003-1848-9695], Sephton, Mark A [0000-0002-2190-5402], Watson, Jonathan S [0000-0003-0354-1729], Salge, Tobias [0000-0002-4414-4917], Shirley, Katherine A [0000-0003-0669-7497], Curtis, Rowan J [0000-0002-9554-3053], Warren, Tristram J [0000-0003-3877-0046], Bowles, Neil E [0000-0001-5400-1461], Stuart, Finlay M [0000-0002-6395-7868], Di Nicola, Luigia [0000-0002-7596-474X], Györe, Domokos [0000-0003-4438-8361], Boyce, Adrian J [0000-0002-9680-0787], Shaw, Kathryn MM [0000-0002-3847-9382], Elliott, Tim [0000-0002-0984-0191], Steele, Robert CJ [0000-0003-1406-6855], Povinec, Pavel [0000-0003-0275-794X], Laubenstein, Matthias [0000-0001-5390-4343], Sanderson, David [0000-0002-9615-4412], Cresswell, Alan [0000-0002-5100-8075], Jull, Anthony JT [0000-0002-4079-4947], Sýkora, Ivan [0000-0003-3447-5621], Sridhar, Sanjana [0000-0003-1179-2093], Harrison, Richard J [0000-0003-3469-762X], Willcocks, Francesca M [0000-0002-3726-0258], Hallatt, Daniel [0000-0002-4426-9891], Wozniakiewicz, Penny J [0000-0002-1441-4883], Burchell, Mark J [0000-0002-2680-8943], Alesbrook, Luke S [0000-0001-9892-281X], Dignam, Aishling [0000-0001-5408-9061], Almeida, Natasha V [0000-0003-4871-8225], Smith, Caroline L [0000-0001-7005-6470], Humphreys-Williams, Emma R [0000-0002-1397-5785], Schofield, Paul F [0000-0003-0902-0588], Cornwell, Luke T [0000-0003-1428-2160], Spathis, Vassilia [0000-0002-5745-4383], Morgan, Geraint H [0000-0002-7580-6880], Campbell-Burns, Peter [0000-0001-8544-728X], Zanda, Brigitte [0000-0002-4210-7151], Vernazza, Pierre [0000-0002-2564-6743], Bouley, Sylvain [0000-0003-0377-5517], Collins, Gareth S [0000-0002-6087-6149], Young, John S [0000-0001-6583-7643], Horak, Jana [0000-0002-0492-2235], Jones, Dave [0000-0002-7215-0521], Bosley, Steve [0000-0002-9478-8518], Dickinson, Paul [0000-0003-0078-0919], McMullan, Ian [0000-0002-5579-8115], Robson, Derek [0000-0001-7807-9853], Smedley, Andrew RD [0000-0001-7137-6628], McIntyre, Mark [0000-0002-5769-4280], Suttle, Adam A [0000-0002-6075-976X], Fleet, Richard [0000-0002-8366-7673], McMullan, Sarah [0000-0002-7194-6317], Boazman, Sarah J [0000-0003-4694-0818], Dickeson, Zach I [0000-0001-9116-2571], Grindrod, Peter M [0000-0002-0934-5131], Pickersgill, Annemarie E [0000-0001-5452-2849], Suttle, Fiona M [0000-0003-1970-0034], Wilcock, Cathryn [0000-0001-7731-2860], Wilcock, Hannah [0000-0002-1043-2267], Wilcock, Rob [0000-0001-8977-7956], Apollo - University of Cambridge Repository, Science and Technology Facilities Council (STFC), and University of St Andrews. School of Earth & Environmental Sciences

Subjects
MCC, QC Physics, Multidisciplinary, 5101 Astronomical Sciences, NDAS, QB Astronomy, 37 Earth Sciences, 3705 Geology, 5109 Space Sciences, 51 Physical Sciences, QC, QB
Abstract

Funding: This study was supported by urgency funding from the U.K.’s Science and Technology Facilities Council (STFC) as part of the project “Curation and Preliminary Examination of the Winchcombe Carbonaceous Chondrite Fall.” Additional work was funded by STFC through grants ST/N000846/1, ST/T002328/1, ST/T506096/1, and ST/W001128/1 (to L.D., M.R.L., and L.J.Ha.); ST/V000675/1 (to K.H.J. and R.H.J.); ST/P005225/1 (to R.T.); ST/S000348/1 (to M.V.G., P.J.W., and M.J.B.); ST/R00143X/1 (to J.B. and L.J.Hi.); ST/S000615/1 (to G.S.C.); ST/V000799/1 (to P.G.); and ST/V000888/1 (to T.E.). A.J.K. and H.C.B. acknowledge funding support from UK Research and Innovation (UKRI) grant MR/T020261/1. P.L.C. acknowledges funding support from UKRI grant MR/S03465X/1. K.H.J. acknowledges funding support from the Royal Society, grant URF\R\201009. L.J.Ha. and M.R.L. acknowledge funding from Natural Environment Research Council (NERC) National Environmental Isotope Facility (NEIF) grant no. 2406.0321. L.D., M.R.L., and L.J.Ha. acknowledge COVID-19 funding support from the University of Glasgow, UK. D.V. was supported in part by NASA cooperative agreement 80NSSC21M0073. P.P. and I.Sy. acknowledge funding from the VEGA agency, project no.1/0421/20. A.J.T.J. acknowledges support from the European Union and the State of Hungary, cofinanced by the European Regional Development Fund in the project of GINOP-2.3.2-15-2016-00009 “ICER.” P.M.S. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 945298. FRIPON was initiated by funding from ANR (grant N.13-BS05-0009-03), carried out by the Paris Observatory, Muséum National d’Histoire Naturelle, Paris-Saclay University, and Institut Pythéas (LAM-CEREGE). FRIPON data are hosted and processed at Institut Pythéas SIP (Service Informatique Pythéas). The Desert Fireball Network team and Global Fireball Observatory are funded by the Australian Research Council (DP200102073). Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray exposure age confirm that it arrived on Earth shortly after ejection from a primitive asteroid. Recovered only hours after falling, the composition of the Winchcombe meteorite is largely unmodified by the terrestrial environment. It contains abundant hydrated silicates formed during fluid-rock reactions, and carbon- and nitrogen-bearing organic matter including soluble protein amino acids. The near-pristine hydrogen isotopic composition of the Winchcombe meteorite is comparable to the terrestrial hydrosphere, providing further evidence that volatile-rich carbonaceous asteroids played an important role in the origin of Earth's water. Publisher PDF

Published
2022

90. Small Molecule Inhibitors of the Epidermal Growth Factor Receptor

Author

Finlay, M. Raymond V., Ward, Richard A., Bernstein, P. R., Editorial Board Member, Buschauer, A. L., Editorial Board Member, Georg, G. I., Editorial Board Member, Kobayashi, T., Editorial Board Member, Lowe, J. A., Editorial Board Member, Meanwell, N. A., Editorial Board Member, Saxena, A. K., Editorial Board Member, Stilz, U., Editorial Board Member, Supuran, C. T., Editorial Board Member, Zhang, A., Editorial Board Member, Waring, Michael J., editor, Campbell, J. E., Book Editor, Cano, C., Book Editor, Duncan, K. W., Book Editor, Finlay, M. R. V., Book Editor, Gray, N. S., Book Editor, Hardcastle, I. R., Book Editor, Harnor, S., Book Editor, Harris, P. A., Book Editor, Hatcher, J. M., Book Editor, Manley, P. W., Book Editor, Michielin, O., Book Editor, Pan, Z., Book Editor, Pickles, J., Book Editor, Pike, K. G., Book Editor, Röhrig, U. F., Book Editor, Staben, S. T., Book Editor, Stiefl, N. J., Book Editor, Toader, D., Book Editor, Ward, R. A., Book Editor, Zoete, V., Book Editor, and Zuo, Y., Book Editor

Published
2018
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91. Dispersion aspects of periodically amplified soliton transmission systems

Author

Knox, Finlay M.

Subjects
535, Electronic Engineering
Abstract

This thesis presents improvements to optical transmission systems through the use of optical solitons as a digital transmission format, both theoretically and experimentally. An introduction to the main concepts and impairments of optical fibre on pulse transmission is included before introducing the concept of solitons in optically amplified communications and the problems of soliton system design. The theoretical work studies two fibre dispersion profiling schemes and a soliton launch improvement. The first provides superior pulse transmission by optimally tailoring the fibre dispersion to better follow the power, and hence nonlinearity, decay and thus allow soliton transmission for longer amplifier spacings and shorter pulse widths than normally possible. The second profiling scheme examines the use of dispersion compensating fibre in the context of soliton transmission over existing, standard fibre systems. The limits for solitons in uncompensated standard fibre are assessed, before the potential benefits of dispersion compensating fibre included as part of each amplifier are shown. The third theoretical investigation provides a simple improvement to the propagation of solitons in a highly perturbed system. By introducing a section of fibre of the correct length prior to the first system amplifier span, the soliton shape can be better coupled into the system thus providing an improved "average soliton" propagation model. The experimental work covers two areas. An important issue for soliton systems is pulse sources. Three potential lasers are studied, two ring laser configurations and one semiconductor device with external pulse shaping. The second area studies soliton transmission using a recalculating loop, reviewing the advantages and draw-backs of such an experiment in system testing and design.

Published
1995
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92. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Author

Fok, Jacqueline H. L., Ramos-Montoya, Antonio, Vazquez-Chantada, Mercedes, Wijnhoven, Paul W. G., Follia, Valeria, James, Neil, Farrington, Paul M., Karmokar, Ankur, Willis, Sophie E., Cairns, Jonathan, Nikkilä, Jenni, Beattie, David, Lamont, Gillian M., Finlay, M. Raymond V., Wilson, Joanne, Smith, Aaron, O’Connor, Lenka Oplustil, Ling, Stephanie, Fawell, Stephen E., O’Connor, Mark J., Hollingsworth, Simon J., Dean, Emma, Goldberg, Frederick W., Davies, Barry R., and Cadogan, Elaine B.

Published
2019
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93. Adrenal tumours in patients with pathogenic APC mutations: a retrospective study

Author

Lyman Lin, Victoria Beshay, and Finlay Macrae

Subjects
Genetics, Colorectal cancer, APC, Familial adenomatous polyposis, Adrenal tumour, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, QH426-470
Abstract

Abstract Background Adrenal tumours are associated with familial adenomatous polyposis (FAP). In the literature, most studies use the clinical definition of FAP (more than 100 adenomatous polyps found in endoscopic studies). However, not all patients that meet clinical criteria for FAP carry pathogenic mutations in the adenomatous polyposis coli (APC) gene, as there is genetic heterogeneity responsible for FAP with the polyposis sometimes explained by genetic and environmental factors other than pathogenic APC mutations. Reciprocally, not all the patients with pathogenic APC variants will fulfil the classic criteria of FAP. Objective This study aims to investigate the characteristics of adrenal tumours in patients with pathogenic or likely pathogenic APC variants and explore the hormonal function of these patients. Method This is a retrospective cohort study. Patients with pathogenic or likely pathogenic APC variants were recruited and their radiological assessments were reviewed. Patient demographic data, APC variants, adrenal mass characteristics and hormonal testing results were collected. Result The prevalence of adrenal mass was 26.7% (24/90) among patients with pathogenic or likely pathogenic APC variants. Using the classic definition, the prevalence was 32.4% (22/68). Four patients had adrenal hormone testing, two of which had Conn’s syndrome and two had nonspecific subclinical results. Conclusion In our cohort, the prevalence of adrenal tumours among patients with pathogenic and likely pathogenic APC mutations is at least twice to three times higher than the general population prevalence reported from international population-based studies. The hormonal functions of patients with pathogenic APC variants and adrenal tumours can be investigated with routine testing in further research.

Published
2024
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95. Multi-Isotope Geochemical Baseline Study of the Carbon Management Canada Research Institutes CCS Field Research Station (Alberta, Canada), Prior to CO2 Injection

Author

Utley, Rachel E., primary, Martin-Roberts, Emma, additional, Utting, Nicholas, additional, Johnson, Gareth, additional, Györe, Domokos, additional, Zurakowska, Marta, additional, Stuart, Finlay M., additional, Boyce, Adrian J., additional, Darrah, Thomas H., additional, Gulliver, Pauline, additional, Haszeldine, R. Stuart, additional, Lawton, Don, additional, and Gilfillan, Stuart M. V., additional

Published
2023
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100. Impact of CaSO

Author

Benedikt, Ritter, Julia L, Diederich-Leicher, Steven A, Binnie, Finlay M, Stuart, Volker, Wennrich, Andreas, Bolten, and Tibor J, Dunai

Subjects
Soil, Rivers, Desert Climate, Soil Microbiology
Abstract

The Atacama Desert is the driest and oldest desert on Earth. Despite the abundance evidence for long-term landscape stability, there are subtle signs of localised fluvial erosion and deposition since the onset of hyperaridity in the rock record. In the dry core of the Atacama Desert, pluvial episodes allowed antecedent drainage to incise into uplifting fault scarps, which in turn generated sinuous to meandering channels. Incision of ancient alluvial fan surfaces occurred during intermittent fluvial periods, albeit without signs of surface erosion. Fluvial incision during predominantly hyperarid climate periods is evident from these channels in unconsolidated alluvium. The absence of dense vegetation to provide bank stability and strength led us to investigate the potential role of regionally ubiquitous CaSO

Published
2022

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