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362 results on '"Fessler, J. A."'

55. Pharmacotherapy guidelines for the aged by family doctors for the use of family doctors: Part D Basic conditions supporting drug treatment

Author

Wolfring Hj, Kluthe B, Fessler J, Bergert Fw, Loew Pg, Gross J, Luther E, Liesenfeld A, Zimmermann U, Ehrenthal K, Pchalek R, Lang Heinrich W, Sterzing A, Gundermann K, Conrad D, and Seffrin J

Subjects
medicine.medical_specialty, Physical fitness, Nutritional Status, Physical exercise, Internal medicine, Diabetes mellitus, Heart rate, Medicine, Humans, Pharmacology (medical), Decompensation, Practice Patterns, Physicians', Stroke, Exercise, Aged, Pharmacology, business.industry, Nutritional Requirements, Resistance Training, medicine.disease, Nutrition Disorders, Malnutrition, Nutrition Assessment, Heart failure, Physical therapy, Physical Endurance, business, Family Practice
Abstract

Physiological changes in old age: loss of muscle mass; reduction in bone mass; percentage of fat increased; lower amount of body water; lack of thirst; diminishing kidney function (caution: sufficient intake of fluids: 1.5-2 l and moderate intake of protein 8 g/kg body weight); reduced secretion of digestive enzymes, delayed emptying of stomach (which means premature feeling of repletion). Lack of fluids and nutrition is therefore likely. Daily intake of 1,500 kcal and 1.5-2 l fluids is necessary. An indicator for malnutrition is low body weight (defined for persons older than 65 years of age as BMI < 20) and a protein serum concentration < 35 g/l. Malnutrition carries an increased risk of infections, falling and fractures, bed sores, anemia, decompensation of chronic diseases. 10-20% of subjects over 80 years of age show signs of malnutrition, 40-60% of subjects in care institutions or hospitals. There are regressive changes in the locomotor and the nervous system of the elderly which have an effect on physical fitness. These changes reduce strength, endurance, proprioceptive capacity (e.g. coordination, balance) and mobility. Exercise in the old and very old should increase skeletal muscle strength in particular and improve coordination and balance. Regular physical exercise and moderate training has a positive effect on mobility and thereby improves independence and reduces falls. Moreover, it has a positive effect on cardiac output, maximum heart rate, stroke volume and the risk of a cardiovascular event and mortality can be reduced. Moreover, moderate physical exercise is often more effective in treating chronic disease than drug therapy e.g. heart failure, coronary heart disease, asthma/COPD, stroke, diabetes mellitus Type 2, degenerative diseases of the joints, depression and others. Examine cardiovascular risks in persons over the age of 50 before beginning physical exercise. Avoid maximum stress levels.

Published
2009

61. Recommendations for Treating Adult and Geriatric Patients on Multimedication

Author

Bergert, F.W., primary, Braun, M., additional, Ehrenthal, K., additional, Feßler, J., additional, Gross, J., additional, Hüttner, U., additional, Kluthe, B., additional, Liesenfeld, A., additional, Seffrin, J., additional, Vetter, G., additional, Beyer, M., additional, Muth, C., additional, Popert, U., additional, Harder, S., additional, Kirchner, H., additional, and Schubert, I., additional

Published
2014
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66. Automated 3D mapping and shape analysis of the lateral ventricles via fluid registration of multiple surface-based atlases

Author

Denney, T, Fessler, J, Chou, Yi-Yu, Lepore, Natasha, de Zubicaray, Greig, Rose, Stephen, Carmichael, Owen, Becker, James, Toga, Arthur, Thompson, Paul, Denney, T, Fessler, J, Chou, Yi-Yu, Lepore, Natasha, de Zubicaray, Greig, Rose, Stephen, Carmichael, Owen, Becker, James, Toga, Arthur, and Thompson, Paul

Abstract

We developed and validated a new method to create automated 3D parametric surface models of the lateral ventricles, designed for monitoring degenerative disease effects in clinical neuroscience studies and drug trials. First we used a set of parameterized surfaces to represent the ventricles in a manually labeled set of 9 subjects' MRIs (atlases). We fluidly registered each of these atlases and mesh models to a set of MRIs from 12 Alzheimer's disease (AD) patients and 14 matched healthy elderly subjects, and we averaged the resulting meshes for each of these images. Validation experiments on expert segmentations showed that (1) the Hausdorff labeling error rapidly decreased, and (2) the power to detect disease-related alterations monotonically improved as the number of atlases, N, was increased from 1 to 9. We then combined the segmentations with a radial mapping approach to localize ventricular shape differences in patients. In surface-based statistical maps, we detected more widespread and intense anatomical deficits as we increased the number of atlases, and we formulated a statistical stopping criterion to determine the optimal value of N. Anterior horn anomalies in Alzheimer's patients were only detected with the multi-atlas segmentation, which clearly outperformed the standard single-atlas approach.

Published
2007

76. Pharmacotherapy guidelines for the aged by family doctors for the use of family doctors – Part D Basic conditions supporting drug treatment. Part E Guidelines group, disclaimer, internet addresses

Author

Bergert, F.W., primary, Conrad, D., additional, Ehrenthal, K., additional, Feßler, J., additional, Gross, J., additional, Gundermann, K., additional, Kluthe, B., additional, Heinrich, W. Lang, additional, Liesenfeld, A., additional, Loew, P.G., additional, Luther, E., additional, Pchalek, R., additional, Seffrin, J., additional, Sterzing, A., additional, Wolfring, H.-J., additional, and Zimmermann, U., additional

Published
2009
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79. Loss of high-molecular-weight cytokeratin antigenicity in prostate tissue obtained by transurethral resections.

Author

Multhaupt, H A, Fessler, J N, Warhol, M J, Multhaupt, H A, Fessler, J N, and Warhol, M J

Abstract

Udgivelsesdato: 2000-Dec, OBJECTIVE: Staining of prostatic basal cells for the expression of high-molecular-weight cytokeratin has been suggested as a way of distinguishing benign from malignant prostate glands. We evaluated the utility of high-molecular-weight cytokeratin in the diagnosis of malignancy in prostate specimens obtained in various ways. DESIGN: Prostate tissues obtained from needle biopsies, transurethral resections, and total prostatectomies were immunostained with monoclonal antibody 34betaE12, an antibody directed against high-molecular-weight cytokeratins. RESULTS: Antiserum to high-molecular-weight cytokeratin only stained the basal cells in normal glands in 3 (12%) of 25 specimens obtained by transurethral resection. Other antigens, such as the alternate 10-nm filament protein vimentin, were unaffected and were detected in 100% of these specimens. However, keratin antigenicity in transurethral biopsies could be restored in these specimens by antigen retrieval in a low pH citrate buffer using a microwave heat technique. Keratin staining in needle biopsies and total prostatectomies was unaffected. CONCLUSION: In summary, our results indicate the technique of transurethral resection results in a specific loss of keratin antigenicity. This limits the utility of anticytokeratin 34betaE12 in interpreting transurethral resections without the application of antigen retrieval.

Published
2000

90. Rhe functions of ECM proteins in Drosophila development

Author

Fessler, L.I., Kramerova, I, Kawaguchi, N, Nelson, R, Bunch, T, Brower, D, Kusche-Gullberg, M, Fessler, J, Fessler, L.I., Kramerova, I, Kawaguchi, N, Nelson, R, Bunch, T, Brower, D, Kusche-Gullberg, M, and Fessler, J

Published
1998

91. Das Leitlinien-Clearingverfahren Asthma bronchiale - 1. Methodik und Ergebnisse der formalen Bewertung

Author

Thole, H., primary, Weingart, O., additional, Lampert, U., additional, Bassler, D., additional, Fessler, J., additional, Forster, J., additional, Franzen, D., additional, Geraedts, M., additional, Kroegel, C., additional, Mörike, K., additional, Schmitz, M., additional, Scholz, R., additional, Teske, S., additional, and Ollenschläger, G., additional

Published
2003
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94. Detection of human papillomavirus in laryngeal lesions by in situ hybridization.

Author

Multhaupt, H A, Fessler, J N, Warhol, M J, Multhaupt, H A, Fessler, J N, and Warhol, M J

Abstract

Udgivelsesdato: 1994-Dec, Human papillomavirus (HPV) is associated with human neoplasms of squamous epithelium. Squamous papillomas and verrucous carcinomas are two types of squamous neoplasms of the larynx that present difficult problems in differential diagnosis. Using in situ hybridization with biotinylated DNA probes, we examined benign squamous papillomas and verrucous squamous carcinomas of the larynx for the presence of HPV. Forty-two biopsy specimens from 18 patients with laryngeal papillomas and 11 biopsy specimens from seven patients with verrucous carcinomas were obtained from the files of Pennsylvania Hospital, Philadelphia, PA. Tissue sections were hybridized with an HPV DNA cocktail. The HPV-positive cases then were subtyped further with DNA probes specific for HPV subtypes 6/11, 16/18, and 31/33/35. All benign squamous papillomas (42 of 42) were positive for HPV subtype 6/11. None of the verrucous carcinomas contained demonstrable HPV (none of 11). Some of the squamous papillomas were recurrences, which shows the persistence of the virus. These results indicate that laryngeal papillomas may be related to HPV, but verrucous carcinomas are not.

Published
1994

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