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The NIKA2 camera operating at the IRAM 30-m telescope excels in high-angular resolution mapping of the thermal Sunyaev-Zel’dovich effect towards galaxy clusters at intermediate and high-redshift. As part of the NIKA2 guaranteed-time, the SZ Large Program (LPSZ) aims at tSZ-mapping a representative sample of SZ-selected galaxy clusters in the catalogues of the Planck satellite and of the Atacama Cosmology Telescope, and also observed in X-ray with XMM-Newton or Chandra. Having completed observations in January 2023, we present tSZ maps of 38 clusters spanning the targeted mass (3 < M500/1014M⊙ < 10) and redshift (0.5 < z < 0.9) range. The first in-depth studies of individual clusters highlight the potential of combining tSZ and X-ray observations at similar angular resolution for precised mass measurements under the hydrostatic assumption MHSE. These were milestones for the development of a standard data analysis pipeline to go from NIKA2 raw data to the thermodynamic properties of galaxy clusters for the upcoming LPSZ data release. Final products will include measurements of the mean pressure profile of unprecedented quality and MHSE-observable scaling relation using a distinctive SZ-selected sample, which will be key for ultimately improving the accuracy of cluster-based cosmology.

We present a study on the bias of hydrostatic masses with respect to lensing mass estimates for a sample of 53 clusters in a redshift range between z = 0.05 and 1.07. The M500 mass for each cluster was inferred from X-ray and lensing data, without using a priori observable-mass scaling relations. Cluster masses of our reference analysis were reconstructed homogeneously and we assess the systematic dispersion of those homogeneous masses with respect to other published mass estimates. We obtain an hydrostatic-to-lensing mass bias of (1 − b) = 0.74−0.07+0.08 and no significant evidence of evolution with redshift.

Christian Morgenstern verstand den Humor als einen alternativen Weg in die Wissenschaft, von der er sich wegen ‚Dilettantismus‘ ausgeschlossen sah. Die Entwürfe aus dem Nachlass zeugen von dieser Leidenschaft: Im posthum erschienenen Text Aus dem Anzeigenteil einer Tageszeitung des Jahres 2407 stellt Morgenstern eine Reihe von „Erfindungen“ vor. Unter ihnen findet man die Anzeige für Künstliche Köpfe, die über die natürlichen gestülpt werden und damit nur Vorteile bieten können. Morgenstern träumt von einer Hybridisierung mit technischen Apparaten, die Hören und Sehen schärfen und den Menschen in eine technologische Puppe verwandeln. Wovon sie träumen, das ist jedoch eine ganz andere Frage …

We present the all-sky Planck catalogue of Sunyaev-Zeldovich (SZ) sources detected from the 29 month full-mission data. The catalogue (PSZ2) is the largest SZ-selected sample of galaxy clusters yet produced and the deepest systematic all-sky surveyof galaxy clusters. It contains 1653 detections, of which 1203 are confirmed clusters with identified counterparts in external data sets, and is the first SZ-selected cluster survey containing >103 confirmed clusters. We present a detailed analysis of the survey selection function in terms of its completeness and statistical reliability, placing a lower limit of 83% on the purity. Using simulations, we find that the estimates of the SZ strength parameter Y5R500are robust to pressure-profile variation and beam systematics, but accurate conversion to Y500 requires the use of prior information on the cluster extent. We describe the multi-wavelength search for counterparts in ancillary data, which makes use of radio, microwave, infra-red, optical, and X-ray data sets, and which places emphasis on the robustness of the counterpart match. We discuss the physical properties of the new sample and identify a population of low-redshift X-ray under-luminous clusters revealed by SZ selection. These objects appear in optical and SZ surveys with consistent properties for their mass, but are almost absent from ROSAT X-ray selected samples.

We present the all-sky Planck catalogue of Sunyaev-Zeldovich (SZ) sources detected from the 29 month full-mission data. The catalogue (PSZ2) is the largest SZ-selected sample of galaxy clusters yet produced and the deepest systematic all-sky surveyof galaxy clusters. It contains 1653 detections, of which 1203 are confirmed clusters with identified counterparts in external data sets, and is the first SZ-selected cluster survey containing >103 confirmed clusters. We present a detailed analysis of the survey selection function in terms of its completeness and statistical reliability, placing a lower limit of 83% on the purity. Using simulations, we find that the estimates of the SZ strength parameter Y5R500are robust to pressure-profile variation and beam systematics, but accurate conversion to Y500 requires the use of prior information on the cluster extent. We describe the multi-wavelength search for counterparts in ancillary data, which makes use of radio, microwave, infra-red, optical, and X-ray data sets, and which places emphasis on the robustness of the counterpart match. We discuss the physical properties of the new sample and identify a population of low-redshift X-ray under-luminous clusters revealed by SZ selection. These objects appear in optical and SZ surveys with consistent properties for their mass, but are almost absent from ROSAT X-ray selected samples.

We present the results of approximately three years of observations of Planck Sunyaev-Zeldovich (SZ) sources with telescopes at the Canary Islands observatories as part of the general optical follow-up programme undertaken by the Planck Collaboration. In total, 78 SZ sources are discussed. Deep-imaging observations were obtained for most of these sources; spectroscopic observations in either in long-slit or multi-object modes were obtained for many. We effectively used 37.5 clear nights. We found optical counterparts for 73 of the 78 candidates. This sample includes 53 spectroscopic redshift determinations, 20 of them obtained with a multi-object spectroscopic mode. The sample contains new redshifts for 27 Planck clusters that were not included in the first Planck SZ source catalogue (PSZ1).

We present the results of approximately three years of observations of Planck Sunyaev-Zeldovich (SZ) sources with telescopes at the Canary Islands observatories as part of the general optical follow-up programme undertaken by the Planck Collaboration. In total, 78 SZ sources are discussed. Deep-imaging observations were obtained for most of these sources; spectroscopic observations in either in long-slit or multi-object modes were obtained for many. We effectively used 37.5 clear nights. We found optical counterparts for 73 of the 78 candidates. This sample includes 53 spectroscopic redshift determinations, 20 of them obtained with a multi-object spectroscopic mode. The sample contains new redshifts for 27 Planck clusters that were not included in the first Planck SZ source catalogue (PSZ1).

The intertwining of landscape and face belongs to human spatial epistemology: as suggested by Matteo Meschiari, primitive humans used to orientate themselves in landscape through recognition of facial patterns. By reflecting upon Marlen Haushofer’s novel The Wall (Die Wand), the article aims to question the semantic of the “face of the landscape” in the wake of an imagined nuclear apocalypse that leaves behind a cat, a cow, a dog, a woman and a wall. The wall transcends the boundaries between human and other-than-human: in terms of Roberto Marchesini, it creates a somato-landscape – a hybridization of inner and outer landscapes typical of post-human awareness. Finally, such a landscape culminates in the dismissal of the pre-apocalyptic culture of the face: faces no longer function as a means of recognition.

We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev-Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catalogue, reporting the further confirmation of 86 Planck-discovered clusters. In total, the PSZ1 now contains 947 confirmed clusters, of which 214 were confirmed as newly discovered clusters through follow-up observations undertaken by the Planck Collaboration. The updated PSZ1 contains redshifts for 913 systems, of which 736 (~ 80.6%) are spectroscopic, and associated mass estimates derived from the Yz mass proxy. We also provide a new SZ quality flag for the remaining 280 candidates. This flag was derived from a novel artificial neural-network classification of the SZ signal. Based on this assessment, the purity of the updated PSZ1 catalogue is estimated to be 94%. In this release, we provide the full updated catalogue and an additional readme file with further information on the Planck SZ detections.

We update the all-sky Planck catalogue of 1227 clusters and cluster candidates (PSZ1) published in March 2013, derived from detections of the Sunyaev-Zeldovich (SZ) effect using the first 15.5 months of Planck satellite observations. As an addendum, we deliver an updated version of the PSZ1 catalogue, reporting the further confirmation of 86 Planck-discovered clusters. In total, the PSZ1 now contains 947 confirmed clusters, of which 214 were confirmed as newly discovered clusters through follow-up observations undertaken by the Planck Collaboration. The updated PSZ1 contains redshifts for 913 systems, of which 736 (~ 80.6%) are spectroscopic, and associated mass estimates derived from the Yz mass proxy. We also provide a new SZ quality flag for the remaining 280 candidates. This flag was derived from a novel artificial neural-network classification of the SZ signal. Based on this assessment, the purity of the updated PSZ1 catalogue is estimated to be 94%. In this release, we provide the full updated catalogue and an additional readme file with further information on the Planck SZ detections.

A Shipwreck in the Garden Estrangement and Confusion in Utopic Landscape in Johann Gottfried Schnabel’s Isle Felsenburg This essay analyses the description of the garden in the first volume of Isle Felsenburg (1731), a utopian novel by Johann Gottfried Schnabel. The paper aims to underline the central role of both ‘wonder’ and ‘estrangement’ in creating a utopian landscape by focusing on the garden of Albert Julius, patriarch of the community. While the beauty of the garden astonishes the narrator, it also results in estrangement, as it drives the reader away from the present into the creatural past of humankind, a lost Eden. Such estrangement is a form of displacement: the subject is incapable of finding its own place in nature.

The Planck Collaboration has shown that the number of clusters as a function of their mass and redshift is an extremely powerful tool for cosmological analyses. However, the true cluster mass is not directly measurable. Among the possible approaches, clusters mass could be related to different observables via self similar scaling law. These observables are related to the baryonic components of which a cluster is composed. However, the theoretical relations that allow the use of these proxies often are affected by observational and physical biases, which impacts on the determination of the cluster mass. Fortunately, cosmological simulations are an extremely powerful tool to assess these problems. We present our calibration of the scaling relation between mass and velocity dispersion of galaxy members from the study of the simulated clusters of The Three Hundred project with mass above 1013M⊙. In order to investigate the presence of a redshift dependence, we analyzed 16 different redshifts between z = 0 and z = 2. Finally, we investigated the impact of different AGN feedback models.

Cluster number count is a major cosmological probe for the next generation of cosmological large scale-structure surveys like the one expected from the Euclid satellite mission. Cosmological constraints will be mainly limited by the understanding of the selection function (SF), which characterize the probability of detecting a cluster of a given mass and redshift. The SF can be estimated by injecting realistic simulated clusters into the survey and re-applying the detection procedure. For this purpose we intend to use The Three Hundreds project, a 324 cluster sample simulated with full-physics hydrodynamical re-simulations. In this paper we concentrate on the study of the distribution of member galaxies in the cluster sample. First, we study possible resolution effects by comparing low and high resolution simulations. Finally, accounting for the latter we derive the density profiles of the member galaxies and discuss their evolution with cluster mass and redshift.

We present a multi-probe analysis of the well-known galaxy cluster CL J1226.9+3332 as a proof of concept for multi-wavelength studies within the framework of the NIKA2 Sunyaev-Zel’dovich Large Program (LPSZ). CL J1226.9+3332 is a massive and high redshift (z = 0.888) cluster that has already been observed at several wavelengths. A joint analysis of the thermal SZ (tSZ) effect at millimeter wavelength with the NIKA2 camera and in X-ray with the XMM-Newton satellite permits the reconstruction of the cluster’s thermodynamical properties and mass assuming hydrostatic equilibrium. We test the robustness of our mass estimates against different definitions of the data analysis transfer function. Using convergence maps reconstructed from the data of the CLASH program we obtain estimates of the lensing mass, which we compare to the estimated hydrostatic mass. This allows us to measure the hydrostatic-to-lensing mass bias and the associated systematic effects related to the NIKA2 measurement. We obtain M500HSE = (7:65 ± 1:03) × 1014M⊙ and M500lens = (7:35 ± 0:65) × 1014M⊙, which implies a HSE-to-lensing bias consistent with 0 within 20%.

Starting from the clusters included in the NIKA sample and in the NIKA2 Sunyaev-Zel’dovich Large Program (LPSZ) we have selected a sample of six common objects with the Cluster Lensing And Supernova survey with Hubble (CLASH) lensing data. For the LPSZ clusters we have at our disposal both high-angular resolution observations of the thermal SZ with NIKA and NIKA2 and X-ray observations with XMM-Newton from which hydrostatic mass estimates can be derived. In addition, the CLASH dataset includes lensing convergence maps that can be converted into lensing estimates of the total mass of the cluster. One-dimensional mass profiles are used to derive integrated mass estimates accounting for systematic effects (data processing, modeling, etc.). Two-dimensional analysis of the maps can reveal substructures in the cluster and, therefore, inform us about the dynamical state of each system. Moreover, we are able to study the hydrostatic mass to lensing mass bias, across different morphology and a range of redshift clusters to give more insight on the hydrostatic mass bias. The analysis presented in this proceeding follows the study discussed in [20].

PSZ2 G091.83+26.11 is a massive galaxy cluster with M500 = 7:43 × 1014M⊙ at z = 0:822. This object exhibits a complex morphology with a clear bimodality observed in X-rays. However, it was detected and analysed in the Planck sample as a single, spherical cluster following a universal profile [1]. This model can lead to miscalculations of thermodynamical quantities, like the pressure profile. As future multiwavelength cluster experiments will detect more and more objects at higher redshifts (where we expect the fraction of merging objects to be higher), it is crucial to quantify this systematic effect. In this work, we use high-resolution observations of PSZ2 G091.83+26.11 by the NIKA2 camera to integrate the morphological characteristics of the cluster in our modelling. This is achieved by fitting a two-halo model to the SZ image and then by reconstruction of the resulting projected pressure profile. We then compare these results with the spherical assumption.

The NIKA2 Guaranteed-Time SZ Large Program (LPSZ) is dedicated to the high-angular resolution SZ mapping of a representative sample of 45 SZ-selected galaxy clusters drawn from the catalogues of the Planck satellite, or of the Atacama Cosmology Telescope. The LPSZ sample spans a mass range from 3 to 11 × 1014M⊙ and a redshift range from 0:5 to 0:9, extending to higher redshift and lower mass the previous samples dedicated to the cluster mass calibration and universal properties estimation. The main goals of the LPSZ are the measurement of the average radial profile of the ICM pressure up to R500 by combining NIKA2 with Planck or ACT data, and the estimation of the scaling law between the SZ observable and the mass using NIKA2, XMM-Newton and Planck/ACT data. Furthermore, combining LPSZ data with existing or forthcoming public data in lensing, optical/NIR or radio domains, we will build a consistent picture of the cluster physics and further gain knowledge on the mass estimate as a function of the cluster morphology and dynamical state. We give an overview of the LPSZ, present recent results and discuss the future implication for cosmology with galaxy clusters.

Several methods are used to evaluate, from observational data, the dynamical state of galaxy clusters. Among them, the morphological analysis of cluster images is well suited for this purpose. We report a new approach to the morphology, which consists in analytically modelling the images with a set of orthogonal functions, the Zernike polynomials (ZPs). We validated the method on mock high-resolution Compton parameter maps of synthetic galaxy clusters from The Three Hundred project. To classify the maps for their morphology we defined a single parameter, C, by combining the contribution of some ZPs in the modelling. We verify that C is linearly correlated with a combination of common morphological parameters and also with a proper 3D dynamicalstate indicator available for the synthetic clusters we used. We also show the early results of the Zernike modelling applied on Compton parameter maps of local clusters (z < 0:1) observed by the Planck satellite. At last, we report the preliminary results of this kind of morphological analysis on mock X-ray maps of The Three Hundred clusters.

The simulation database of The Three Hundred Project has been used to pick synthetic clusters of galaxies with properties close to the observational targets of the NIKA2 camera Sunyaev–Zeldovich (SZ) Large Program. Cross–matching of cluster parameters such as mass and redshift of the cluster in the two databases has been implemented to generate the so–called twin samples for the Large Program. This SZ Large Program is observing a selection of galaxy clusters at intermediate and high redshift (0:5 < z < 0:9), covering one order of magnitude in mass. These are SZ–selected clusters from the Planck and Atacama Cosmology Telescope catalogs, wherein the selection is based on their integrated Compton parameter values, Y500: the value of the parameter within the characteristics radius R500. The Three Hundred hydrodynamical simulations provide us with hundreds of clusters satisfying these redshift, mass, and Y500 requirements. In addition to the standard post-processing analysis of the simulation, mock observational maps are available mimicking X–ray, optical, gravitational lensing, radio, and SZ observations of galaxy clusters. The primary goal of employing the twin samples is to compare different cluster mass proxies from synthetic X–ray, SZ effect and optical maps (via the velocity dispersion of member galaxies and lensing κ-maps) of the clusters. Eventually, scaling laws between different mass proxies and the cluster mass will be cross–correlated to reduce the scatter on the inferred mass and the mass bias will be related to various physical parameters.

An accurate reconstruction of galaxy cluster masses is key to use this population of objects as a cosmological probe. In this work we present a study on the hydrostatic-to-lensing mass scaling relation for a sample of 53 clusters whose masses were reconstructed homogeneously in a redshift range between z = 0.05 and 1.07. The M500 mass for each cluster was indeed inferred from the mass profiles extracted from the X-ray and lensing data, without using a priori observable-mass scaling relations. We assessed the systematic dispersion of the masses estimated with our reference analyses with respect to other published mass estimates. Accounting for this systematic scatter does not change our main results, but enables the propagation of the uncertainties related to the mass reconstruction method or used dataset. Our analysis gives a hydrostatic-to-lensing mass bias of (1−b) = 0.739−0.070+0.075 and no evidence of evolution with redshift. These results are robust against possible subsample differences. [ABSTRACT FROM AUTHOR]

The determination of the mass of galaxy clusters from observations is subject to systematic uncertainties. Beyond the errors due to instrumental and observational systematic effects, in this work we investigate the bias introduced by modelling assumptions. In particular, we consider the reconstruction of the mass of galaxy clusters from convergence maps employing spherical mass density models. We made use of THE THREE HUNDRED simulations, selecting clusters in the same redshift and mass range as the NIKA2 Sunyaev-Zel'dovich Large Programme sample: 3 ≤ M500/1014 M⊙ ≤ 10 and 0.5 ≤ z ≤ 0.9. We studied different modelling and intrinsic uncertainties that should be accounted for when using the single cluster mass estimates for scaling relations. We confirm that the orientation of clusters and the radial ranges considered for the fit have an important impact on the mass bias. The effect of the projection adds uncertainties to the order of 10–16% to the mass estimates. We also find that the scatter from cluster to cluster in the mass bias when using spherical mass models is less than 9% of the true mass of the clusters. [ABSTRACT FROM AUTHOR]

Summary: The DNA damage response (DDR) is the cellular process of preserving an intact genome and is often deregulated in lymphoma cells. The ataxia telangiectasia and Rad3‐related (ATR) kinase is a crucial factor of DDR in the response to DNA single‐strand breaks. ATR inhibitors are agents that have shown considerable clinical potential in this context. We characterized the activity of the ATR inhibitor elimusertib (BAY 1895344) in a large panel of lymphoma cell lines. Furthermore, we evaluated its activity combined with the clinically approved PI3K inhibitor copanlisib in vitro and in vivo. Elimusertib exhibits potent anti‐tumour activity across various lymphoma subtypes, which is associated with the expression of genes related to replication stress, cell cycle regulation and, as also sustained by CRISPR Cas9 experiments, CDKN2A loss. In several tumour models, elimusertib demonstrated widespread anti‐tumour activity stronger than ceralasertib, another ATR inhibitor. This activity is present in both DDR‐proficient and DDR‐deficient lymphoma models. Furthermore, a combination of ATR and PI3K inhibition by treatment with elimusertib and copanlisib has in vitro and in vivo anti‐tumour activity, providing a potential new treatment option for lymphoma patients. [ABSTRACT FROM AUTHOR]