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55. European Birth Cohorts for Environmental Health Research

Author

Vrijheid, Martine, Casas, Maribel, Bergström, Anna, Carmichael, Amanda, Cordier, Sylvaine, Eggesbø, Merete, Eller, Esben, Fantini, Maria P., Fernández, Mariana F., Fernández-Somoano, Ana, Gehring, Ulrike, Grazuleviciene, Regina, Hohmann, Cynthia, Karvonen, Anne M., Keil, Thomas, Kogevinas, Manolis, Koppen, Gudrun, Krämer, Ursula, Kuehni, Claudia E., Magnus, Per, Majewska, Renata, Andersen, Anne-Marie Nybo, Patelarou, Evridiki, Petersen, Maria Skaalum, Pierik, Frank H., Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Santos, Ana Cristina, Slama, Rémy, Sram, Radim J., Thijs, Carel, Tischer, Christina, Toft, Gunnar, Trnovec, Tomáš, Vandentorren, Stephanie, Vrijkotte, Tanja G.M., Wilhelm, Michael, Wright, John, and Nieuwenhuijsen, Mark

Published
2012

60. Socio-economic inequalities in health, habits and self-care during pregnancy in Spain

Author

Larranaga, Isabel, Santa-Marina, Loreto, Begiristain, Haizea, Machon, Monica, Vrijheid, Martine, Casas, Maribel, Tardon, Adonina, Fernandez-Somoano, Ana, Llop, Sabrina, Rodriguez-Bernal, Clara L., and Fernandez, Mariana F.

Subjects
Pregnancy -- Health aspects, Life style -- Research -- Health aspects, Health care disparities -- Research, Self-care, Health -- Research, Pregnant women -- Health aspects -- Behavior, Health care industry
Abstract

Socioeconomic disadvantage can be harmful for mother's health and can influence child's health long term. The aim of this study is to analyse social inequalities between pregnant women from four INMA (INfancia y Medio Ambiente) cohorts. The analysis included 2,607 pregnant women recruited between 2004 and 2008 from four INMA cohorts. Data on maternal characteristics were collected through two questionnaires completed in the first and third trimester of pregnancy. The relationship between socioeconomic status (SES) and maternal health, dietary intake, lifestyle habits and self-care related variables was modelled using logistic regression analysis. 33.5% of women had a university level of education and 47% had high occupational class. Women with higher SES reported healthier habits, fewer complications during pregnancy, better weight gain control and attended more prenatal appointments than women with lower SES. The risk of sedentary behaviour and passive smoking was higher among women with a lower level of education (OR = 1.7, 95% CI 1.3-2.2 and OR = 1.6, 95% CI 1.2-2.3, respectively) and with less skilled occupations (OR = 1.7, 95% CI 1.4-2.0 and OR = 1.2, 95% CI 1.0-1.5, respectively). Although both SES indicators--occupation and education--act as social determinants of diet, occupation was a more powerful determinant than education. For other lifestyle and self-caring variables, education was a more powerful predictor than occupation. Social inequalities were observed in health, habits and self-care during pregnancy. Proper care during pregnancy requires the control of common clinical variables and the knowledge of socioeconomic conditions of the pregnant women. Keywords Health inequalities * Pregnancy * Socioeconomic status * Habits * Self-care, Introduction There is a broad consensus that social and economic conditions have an impact on health [1], particularly in maternal and child health [2]. The conceptual framework of the Commission [...]

Published
2013
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61. Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study

Author

Aguilera, Inmaculada, Pedersen, Marie, Garcia-Esteban, Raquel, Ballester, Ferran, Basterrechea, Mikel, Esplugues, Ana, Fernandez-Somoano, Ana, Lertxundi, Aitana, Tardon, Adonina, and Sunyer, Jordi

Subjects
Respiratory tract diseases -- Risk factors, Ear -- Inflammation, Infants (Newborn) -- Diseases, Eczema -- Risk factors, Air pollution -- Health aspects, Environmental issues, Health
Abstract

BACKGROUND: Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health. OBJECTIVES: We studied the association of air pollution exposure during pregnancy and [...]

Published
2013

63. Prenatal exposure to N[O.sub.2] and ultrasound measures of fetal growth in the Spanish INMA cohort

Author

Iniguez, Carmen, Esplugues, Ana, Sunyer, Jordi, Basterrechea, Mikel, Fernandez-Somoano, Ana, Costa, Olga, Estarlich, Marisa, Aguilera, Inmaculada, Lertxundi, Aitana, Tardon, Adonina, Guxens, Monica, Murcia, Mario, Lopez-Espinosa, Maria-Jose, and Ballester, Ferran

Subjects
Environmental health -- Research, Nitrogen dioxide -- Health aspects, Medical research, Medicine, Experimental, Maternal-fetal exchange -- Health aspects, Fetus -- Growth, Environmental issues, Health
Abstract

BACKGROUND: Air pollution exposure during pregnancy has been associated with impaired fetal growth. However, few studies have measured fetal biometry longitudinally, remaining unclear as to whether there are windows of special vulnerability. OBJECTIVE: The aim was to investigate the impact of nitrogen dioxide (N[O.sub.2]) exposure on fetal and neonatal biometry in the Spanish INMA study. METHODS: Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were evaluated for up to 2,478 fetuses in each trimester of pregnancy. Size at 12, 20, and 34 weeks of gestation and growth between these points, as well as anthropometry at birth, were assessed by SD scores derived using cohort-specific growth curves. Temporally adjusted land-use regression was used to estimate exposure to N[O.sub.2] at home addresses for up to 2,415 fetuses. Associations were investigated by linear regression in each cohort and subsequent meta-analysis. RESULTS: A 10-µg/[m.sup.3] increase in average exposure to N[O.sub.2] during weeks 0-12 was associated with reduced growth at weeks 0-12 in AC (-2.1%; 95% CI: -3.7, -0.6) and EFW (-1.6%; 95% CI: -3.0, -0.3). The same exposure was inversely associated with reduced growth at weeks 20-34 in BPD (-2.6%; 95% CI: -3.9, -1.2), AC (-1.8%; 95% CI: -3.3, -0.2), and EFW (-2.1%; 95% CI: -3.7, -0.2). A less consistent pattern of association was observed for FL. The negative association of this exposure with BPD and EFW was significantly stronger in smoking versus nonsmoking mothers. CONCLUSIONS: Maternal exposure to N[O.sub.2] in early pregnancy was associated with reduced fetal growth based on ultrasound measures of growth during pregnancy and measures of size at birth. http://dx.doi.org/10.1289/ehp.1409423, Introduction Fetal development is a global public health concern because growth in utero is a good indicator of perinatal and postnatal health (Gluckman et al. 2008; Kramer 2003). Its vulnerability [...]

Published
2016
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64. Organochlorine compounds and ultrasound measurements of fetal growth in the INMA cohort (Spain)

Author

Lopez-Espinosa, Maria-Jose, Murcia, Mario, Iniguez, Carmen, Vizcaino, Esther, Costa, Olga, Fernandez-Somoano, Ana, Basterrechea, Mikel, Lertxundi, Aitana, Guxens, Monica, Gascon, Mireia, Goni-Irigoyen, Fernando, Grimalt, Joan O., Tardon, Adonina, and Ballester, Ferran

Subjects
Pregnancy -- Environmental aspects -- Health aspects, Fetus -- Growth, Organochlorine compounds -- Health aspects, Environmental issues, Health
Abstract

BACKGROUND: Several studies have reported decreases in birth size associated with exposure to organochlorine compounds (OCs), but uncertainties remain regarding the critical windows of prenatal exposure and the effects on fetal body segments. OBJECTIVE: We examined the relationship between prenatal OC concentrations and fetal anthropometry. METHODS: We measured 4,4'-dichlorodiphenyldichloroethylene (4,4'-DDE), hexachlorobenzene (HCB), and polychlorinated biphenyl (PCB) congeners (138, 153, and 180) in 2,369 maternal and 1,140 cord serum samples in four Spanish cohorts (2003-2008). We used linear mixed models to obtain longitudinal growth curves for estimated fetal weight (EFW), abdominal circumference (AC), biparietal diameter (BPD), and femur length (FL) adjusted by parental and fetal characteristics. We calculated standard deviation (SD) scores of growth at 0-12, 12-20, and 20-34 weeks of gestation as well as size at gestational week 34 for the four parameters. We studied the association between OCs and the fetal outcomes by cohort-specific linear models and subsequent meta-analyses. RESULTS: PCBs were associated with a reduction in AC up to mid-pregnancy, and BPD and FL from gestational week 20 onward. An inverse association was also found between HCB and AC growth in early pregnancy. The reduction of these parameters ranged from -4% to -2% for a doubling in the OC concentrations. No association between 4,4'-DDE and fetal growth was observed. CONCLUSIONS: To our knowledge, this is the first study to report an association between prenatal exposure to some PCBs and HCB and fetal growth: AC during the first two trimesters of pregnancy, and BPD and FL later in pregnancy. http://dx.doi.org/10.1289/ehp.1408907, Introduction Fetal growth is an important indicator of child health because its impairment may be associated with poor neurodevelopment (Richards et al. 2002) and with chronic diseases in adulthood (Barker [...]

Published
2016
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65. Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci

Author

Dai, Juncheng, Li, Zhihua, Amos, Christopher I., Hung, Rayjean J., Tardon, Adonina, Andrew, Angeline S., Chen, Chu, Christiani, David C., Albanes, Demetrios, van der Heijden, Erik H. F. M., Duell, Eric J., Rennert, Gad, Mckay, James D., Yuan, Jian-Min, Field, John K., Manjer, Jonas, Grankvist, Kjell, Le Marchand, Loic, Teare, M. Dawn, Schabath, Matthew B., Aldrich, Melinda C., Tsao, Ming-Sound, Lazarus, Philip, Lam, Stephen, Bojesen, Stig E., Arnold, Susanne, Wu, Xifeng, Haugen, Aage, Janout, Vladimir, Johansson, Mikael, Brhane, Yonathan, Fernandez-Somoano, Ana, Kiemeney, Lambertus A., Davies, Michael P. A., Zienolddiny, Shanbeh, Hu, Zhibin, Shen, Hongbing, Dai, Juncheng, Li, Zhihua, Amos, Christopher I., Hung, Rayjean J., Tardon, Adonina, Andrew, Angeline S., Chen, Chu, Christiani, David C., Albanes, Demetrios, van der Heijden, Erik H. F. M., Duell, Eric J., Rennert, Gad, Mckay, James D., Yuan, Jian-Min, Field, John K., Manjer, Jonas, Grankvist, Kjell, Le Marchand, Loic, Teare, M. Dawn, Schabath, Matthew B., Aldrich, Melinda C., Tsao, Ming-Sound, Lazarus, Philip, Lam, Stephen, Bojesen, Stig E., Arnold, Susanne, Wu, Xifeng, Haugen, Aage, Janout, Vladimir, Johansson, Mikael, Brhane, Yonathan, Fernandez-Somoano, Ana, Kiemeney, Lambertus A., Davies, Michael P. A., Zienolddiny, Shanbeh, Hu, Zhibin, and Shen, Hongbing

Abstract

DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-related variants in lung cancer. In this study, we performed a large-scale case-control study with 20 871 lung cancer cases and 15 971 controls to evaluate the associations between regulatory genetic variants in DHS and lung cancer susceptibility. The expression quantitative trait loci (eQTL) analysis and pathway-enrichment analysis were performed to identify the possible target genes and pathways. In addition, we performed motif-based analysis to explore the lung-cancer-related motifs using sequence kernel association test. Two novel variants, rs186332 in 20q13.3 (C>T, odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.10-1.24, P = 8.45 x 10(-7)) and rs4839323 in 1p13.2 (T>C, OR = 0.92, 95% CI: 0.89-0.95, P = 1.02 x 10(-6)) showed significant association with lung cancer risk. The eQTL analysis suggested that these two SNPs might regulate the expression of MRGBP and SLC16A1, respectively. What's more, the expression of both MRGBP and SLC16A1 was aberrantly elevated in lung tumor tissues. The motif-based analysis identified 10 motifs related to the risk of lung cancer (P < 1.71 x 10(-4)). Our findings suggested that variants in DHS might modify lung cancer susceptibility through regulating the expression of surrounding genes. This study provided us a deeper insight into the roles of DHS-related genetic variants for lung cancer.

Published
2019
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66. Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer : A Mendelian Randomization Analysis

Author

Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming-Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, Mckay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz-Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P. A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., van der Heijden, Erik H. F. M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, Christiani, David C., Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming-Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, Mckay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz-Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P. A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., van der Heijden, Erik H. F. M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, and Christiani, David C.

Abstract

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Published
2019
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67. Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts

Author

Procesos psicológicos básicos y su desarrollo, Oinarrizko psikologia prozesuak eta haien garapena, Jorcano, Ainhoa, Lubczynska, Malgorzata J., Pierotti, Livia, Altug, Hicran, Ballester, Ferrán, Cesaroni, Giulia, El Marroun, Hanan, Fernandez Somoano, Ana, Freire, Carmen, Hanke, Wojciech, Hoek, Gerard, Ibarluzea Maurolagoitia, Jesús María, Iniguez, Carmen, Jansen, Pauline W., Lepeule, Johanna, Markevych, Iana, Polanska, Kinga, Porta, Daniela, Schikowski, Tamara, Slama, Remy, Standl, Marie, Tardón, Adonina, Vrijkotte, Tanja G. M., Von Berg, Andrea, Tiemeier, Henning, Sunyer, Jordi, Guxens, Mónica, Procesos psicológicos básicos y su desarrollo, Oinarrizko psikologia prozesuak eta haien garapena, Jorcano, Ainhoa, Lubczynska, Malgorzata J., Pierotti, Livia, Altug, Hicran, Ballester, Ferrán, Cesaroni, Giulia, El Marroun, Hanan, Fernandez Somoano, Ana, Freire, Carmen, Hanke, Wojciech, Hoek, Gerard, Ibarluzea Maurolagoitia, Jesús María, Iniguez, Carmen, Jansen, Pauline W., Lepeule, Johanna, Markevych, Iana, Polanska, Kinga, Porta, Daniela, Schikowski, Tamara, Slama, Remy, Standl, Marie, Tardón, Adonina, Vrijkotte, Tanja G. M., Von Berg, Andrea, Tiemeier, Henning, Sunyer, Jordi, and Guxens, Mónica

Abstract

Background: The association between air pollution exposure and emotional and behavioural problems in children is unclear. We aimed to assess prenatal and postnatal exposure to several air pollutants and child's depressive and anxiety symptoms, and aggressive symptoms in children of 7-11 years. Methods: We analysed data of 13182 children from 8 European population-based birth cohorts. Concentrations of nitrogen dioxide (NO2), nitrogen oxides (NOx), particulate matter (PM) with diameters of <= 10 mu m (PM10), <= 2.5 mu m (PM2.5), and between 10 and 2.5 mu m (PMcoarse), the absorbance of PM2.5 filters (PM(2.5)abs), and polycyclic aromatic hydrocarbons (PAHs) were estimated at residential addresses of each participant. Depressive and anxiety symptoms and aggressive symptoms were assessed at 7-11 years of age using parent reported tests. Children were classified in borderline/clinical range or clinical range using validated cut offs. Region specific models were adjusted for various socio-economic and lifestyle characteristics and then combined using random effect meta-analysis. Multiple imputation and inverse probability weighting methods were applied to correct for potential attrition bias. Results: A total of 1896 (14.4%) children were classified as having depressive and anxiety symptoms in the borderline/clinical range, and 1778 (13.4%) as having aggressive symptoms in the borderline/clinical range. Overall, 1108 (8.4%) and 870 (6.6%) children were classified as having depressive and anxiety symptoms, and aggressive symptoms in the clinical range, respectively. Prenatal exposure to air pollution was not associated with depressive and anxiety symptoms in the borderline/clinical range (e.g. OR 1.02 [95%CI 0.95 to 1.10] per 10 mu g/m(3) higher NO2) nor with aggressive symptoms in the borderline/clinical range (e.g. OR 1.04 [95%CI 0.96 to 1.12] per 10 mu g/m(3) higher NO2). Similar results were observed for the symptoms in the clinical range, and for postnatal exposures t

Published
2019

68. Elevated platelet count appears to be causally associated with increased risk of lung cancer:A mendelian randomization analysis

Author

Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, McKay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P.A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., Van der Heijden, Erik H.F.M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, Christiani, David C., Zhu, Ying, Wei, Yongyue, Zhang, Ruyang, Dong, Xuesi, Shen, Sipeng, Zhao, Yang, Bai, Jianling, Albanes, Demetrius, Caporaso, Neil E., Landi, Maria Teresa, Zhu, Bin, Chanock, Stephen J., Gu, Fangyi, Lam, Stephen, Tsao, Ming Sound, Shepherd, Frances A., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Chen, Chu, Barnett, Matthew J., Doherty, Jennifer, Bojesen, Stig E., Johansson, Mattias, Brennan, Paul, McKay, James D., Carreras-Torres, Robert, Muley, Thomas, Risch, Angela, Wichmann, Heunz Erich, Bickeboeller, Heike, Rosenberger, Albert, Rennert, Gad, Saliba, Walid, Arnold, Susanne M., Field, John K., Davies, Michael P.A., Marcus, Michael W., Wu, Xifeng, Ye, Yuanqing, Le Marchand, Loic, Wilkens, Lynne R., Melander, Olle, Manjer, Jonas, Brunnstrom, Hans, Hung, Rayjean J., Liu, Geoffrey, Brhane, Yonathan, Kachuri, Linda, Andrew, Angeline S., Duell, Eric J., Kiemeney, Lambertus A., Van der Heijden, Erik H.F.M., Haugen, Aage, Zienolddiny, Shanbeh, Skaug, Vidar, Grankvist, Kjell, Johansson, Mikael, Woll, Penella J., Cox, Angela, Taylor, Fiona, Teare, Dawn M., Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Shen, Hongbing, Hu, Zhibin, Dai, Juncheng, Amos, Christopher I., Han, Younghun, Zhu, Dakai, Goodman, Gary E., Chen, Feng, and Christiani, David C.

Abstract

Background: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non–small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15–2.27; P ¼ 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27–7.06; P ¼ 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Published
2019

69. Dissemination of health technologies: Trends in the use of diagnostic test in breast cancer screening

Author

Natal, C., primary, Fernandez-Somoano, A., additional, Torá-Rocamora, I., additional, Vidal, C., additional, Castells, X., additional, Tardón, A., additional, Buron, Andrea, additional, Castells, Xavier, additional, Corominas, Josep Maria, additional, Domingo, Laia, additional, Rodrıguez-Arana, Ana, additional, Roman, Marta, additional, Servitja, Sonia, additional, Sala, Maria, additional, Tora-Rocamora, Isabel, additional, Vernet, Mar, additional, Andreu, Marisa Bareand Xavier, additional, Benito, Llucia, additional, Vidal, Carmen, additional, Quintana, Maria Jesus, additional, Sola-Roca, Judit, additional, Sanchez, Mar, additional, Natal, Carmen, additional, Tardón, Adonina, additional, Fernandez-Somoano, Ana, additional, Galceran, Jaume, additional, Saladie, Francina, additional, Ferrer, Joana, additional, and Espinas, Josep Alfons, additional

Published
2019
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70. Association between trans fatty acid intake and overweight including obesity in 4 to 5‐year‐old children from the INMA study

Author

Scholz, Alexander, primary, Navarrete‐Muñoz, Eva Maria, additional, García‐de‐la‐Hera, Manuela, additional, Fernandez‐Somoano, Ana, additional, Tardon, Adonina, additional, Santa‐Marina, Loreto, additional, Pereda‐Pereda, Eva, additional, Romaguera, Dora, additional, Guxens, Mònica, additional, Beneito, Andrea, additional, Iñiguez, Carmen, additional, and Vioque, Jesus, additional

Published
2019
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71. Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci

Author

Dai, Juncheng, primary, Li, Zhihua, additional, Amos, Christopher I, additional, Hung, Rayjean J, additional, Tardon, Adonina, additional, Andrew, Angeline S, additional, Chen, Chu, additional, Christiani, David C, additional, Albanes, Demetrios, additional, van der Heijden, Erik H F M, additional, Duell, Eric J, additional, Rennert, Gad, additional, Mckay, James D, additional, Yuan, Jian-Min, additional, Field, John K, additional, Manjer, Jonas, additional, Grankvist, Kjell, additional, Le Marchand, Loic, additional, Teare, M Dawn, additional, Schabath, Matthew B, additional, Aldrich, Melinda C, additional, Tsao, Ming-Sound, additional, Lazarus, Philip, additional, Lam, Stephen, additional, Bojesen, Stig E, additional, Arnold, Susanne, additional, Wu, Xifeng, additional, Haugen, Aage, additional, Janout, Vladimir, additional, Johansson, Mikael, additional, Brhane, Yonathan, additional, Fernandez-Somoano, Ana, additional, Kiemeney, Lambertus A, additional, Davies, Michael P A, additional, Zienolddiny, Shanbeh, additional, Hu, Zhibin, additional, and Shen, Hongbing, additional

Published
2019
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72. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Author

Ji, Xuemei, Bosse, Yohan, Landi, Maria Teresa, Gui, Jiang, Xiao, Xiangjun, Qian, David, Joubert, Philippe, Lamontagne, Maxime, Li, Yafang, Gorlov, Ivan, de Biasi, Mariella, Han, Younghun, Gorlova, Olga, Hung, Rayjean J., Wu, Xifeng, Mckay, James, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil, Johansson, Mattias, Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Bickeboeller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Chen, Chu, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier A., Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher, Wilkens, Lynne, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Erik H. F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnstrom, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brueske, Irene, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances, Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard, McLaughlin, John, Stevens, Victoria, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Gu, Fangyi, Byun, Jinyoung, Kamal, Ahsan, Zhu, Dakai, Tyndale, Rachel F., Wei, Wei-Qi, Chanock, Stephen, Brennan, Paul, Amos, Christopher I., Ji, Xuemei, Bosse, Yohan, Landi, Maria Teresa, Gui, Jiang, Xiao, Xiangjun, Qian, David, Joubert, Philippe, Lamontagne, Maxime, Li, Yafang, Gorlov, Ivan, de Biasi, Mariella, Han, Younghun, Gorlova, Olga, Hung, Rayjean J., Wu, Xifeng, Mckay, James, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil, Johansson, Mattias, Liu, Geoffrey, Bojesen, Stig E., Le Marchand, Loic, Albanes, Demetrios, Bickeboeller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Chen, Chu, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier A., Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher, Wilkens, Lynne, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Erik H. F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnstrom, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brueske, Irene, Manz, Judith, Muley, Thomas, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances, Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard, McLaughlin, John, Stevens, Victoria, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Gu, Fangyi, Byun, Jinyoung, Kamal, Ahsan, Zhu, Dakai, Tyndale, Rachel F., Wei, Wei-Qi, Chanock, Stephen, Brennan, Paul, and Amos, Christopher I.

Abstract

Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.

Published
2018
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73. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study

Author

Fehringer, Gordon Brenner, Darren R. Zhang, Zuo-Feng Lee, Yuan-Chin Amy Matsuo, Keitaro Ito, Hidemi Lan, Qing and Vineis, Paolo Johansson, Mattias Overvad, Kim Riboli, Elio and Trichopoulou, Antonia Sacerdote, Carlotta Stucker, Isabelle and Boffetta, Paolo Brennan, Paul Christiani, David. C. and Hong, Yun-Chul Landi, Maria Teresa Morgenstern, Hal and Schwartz, Ann G. Wenzlaff, Angela S. Rennert, Gad and McLaughlin, John R. Harris, Curtis C. Olivo-Marston, Susan and Orlow, Irene Park, Bernard J. Zauderer, Marjorie Barros Dios, Juan M. Ruano Ravina, Alberto Siemiatycki, Jack and Koushik, Anita Lazarus, Philip Fernandez-Somoano, Ana and Tardon, Adonina Le Marchand, Loic Brenner, Hermann Saum, Kai-Uwe Duell, Eric J. Andrew, Angeline S. and Szeszenia-Dabrowska, Neonila Lissowska, Jolanta Zaridze, David and Rudnai, Peter Fabianova, Eleonora Mates, Dana Foretova, Lenka Janout, Vladimir Bencko, Vladimir Holcatova, Ivana and Pesatori, Angela Cecilia Consonni, Dario Olsson, Ann Straif, Kurt Hung, Rayjean J.

Abstract

It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.

Published
2017

74. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Author

Ji, Xuemei, primary, Bossé, Yohan, additional, Landi, Maria Teresa, additional, Gui, Jiang, additional, Xiao, Xiangjun, additional, Qian, David, additional, Joubert, Philippe, additional, Lamontagne, Maxime, additional, Li, Yafang, additional, Gorlov, Ivan, additional, de Biasi, Mariella, additional, Han, Younghun, additional, Gorlova, Olga, additional, Hung, Rayjean J., additional, Wu, Xifeng, additional, McKay, James, additional, Zong, Xuchen, additional, Carreras-Torres, Robert, additional, Christiani, David C., additional, Caporaso, Neil, additional, Johansson, Mattias, additional, Liu, Geoffrey, additional, Bojesen, Stig E., additional, Le Marchand, Loic, additional, Albanes, Demetrios, additional, Bickeböller, Heike, additional, Aldrich, Melinda C., additional, Bush, William S., additional, Tardon, Adonina, additional, Rennert, Gad, additional, Chen, Chu, additional, Teare, M. Dawn, additional, Field, John K., additional, Kiemeney, Lambertus A., additional, Lazarus, Philip, additional, Haugen, Aage, additional, Lam, Stephen, additional, Schabath, Matthew B., additional, Andrew, Angeline S., additional, Shen, Hongbing, additional, Hong, Yun-Chul, additional, Yuan, Jian-Min, additional, Bertazzi, Pier A., additional, Pesatori, Angela C., additional, Ye, Yuanqing, additional, Diao, Nancy, additional, Su, Li, additional, Zhang, Ruyang, additional, Brhane, Yonathan, additional, Leighl, Natasha, additional, Johansen, Jakob S., additional, Mellemgaard, Anders, additional, Saliba, Walid, additional, Haiman, Christopher, additional, Wilkens, Lynne, additional, Fernandez-Somoano, Ana, additional, Fernandez-Tardon, Guillermo, additional, van der Heijden, Erik H. F. M., additional, Kim, Jin Hee, additional, Dai, Juncheng, additional, Hu, Zhibin, additional, Davies, Michael P. A., additional, Marcus, Michael W., additional, Brunnström, Hans, additional, Manjer, Jonas, additional, Melander, Olle, additional, Muller, David C., additional, Overvad, Kim, additional, Trichopoulou, Antonia, additional, Tumino, Rosario, additional, Doherty, Jennifer, additional, Goodman, Gary E., additional, Cox, Angela, additional, Taylor, Fiona, additional, Woll, Penella, additional, Brüske, Irene, additional, Manz, Judith, additional, Muley, Thomas, additional, Risch, Angela, additional, Rosenberger, Albert, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Shepherd, Frances, additional, Tsao, Ming-Sound, additional, Arnold, Susanne M., additional, Haura, Eric B., additional, Bolca, Ciprian, additional, Holcatova, Ivana, additional, Janout, Vladimir, additional, Kontic, Milica, additional, Lissowska, Jolanta, additional, Mukeria, Anush, additional, Ognjanovic, Simona, additional, Orlowski, Tadeusz M., additional, Scelo, Ghislaine, additional, Swiatkowska, Beata, additional, Zaridze, David, additional, Bakke, Per, additional, Skaug, Vidar, additional, Zienolddiny, Shanbeh, additional, Duell, Eric J., additional, Butler, Lesley M., additional, Koh, Woon-Puay, additional, Gao, Yu-Tang, additional, Houlston, Richard, additional, McLaughlin, John, additional, Stevens, Victoria, additional, Nickle, David C., additional, Obeidat, Ma’en, additional, Timens, Wim, additional, Zhu, Bin, additional, Song, Lei, additional, Artigas, María Soler, additional, Tobin, Martin D., additional, Wain, Louise V., additional, Gu, Fangyi, additional, Byun, Jinyoung, additional, Kamal, Ahsan, additional, Zhu, Dakai, additional, Tyndale, Rachel F., additional, Wei, Wei-Qi, additional, Chanock, Stephen, additional, Brennan, Paul, additional, and Amos, Christopher I., additional

Published
2018
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75. Maternal Metabolic Health Parameters During Pregnancy in Relation to Early Childhood BMI Trajectories.

Author

Montazeri, Parisa, Vrijheid, Martine, Martinez, David, Basterrechea, Mikel, Fernandez‐Somoano, Ana, Guxens, Monica, Iñiguez, Carmen, Lertxundi, Aitana, Murcia, Mario, Tardon, Adonina, Sunyer, Jordi, Valvi, Damaskini, and Fernandez-Somoano, Ana

Subjects
WEIGHT gain in pregnancy, BODY mass index, BLOOD cholesterol, TRIGLYCERIDES, C-reactive protein, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, OBESITY, PREGNANCY complications, RESEARCH, WEIGHT gain, EVALUATION research
Abstract

Objective: The objective of this study was to evaluate the associations between maternal metabolic parameters and early childhood BMI trajectories.Methods: Two thousand two hundred fifty-one children born in Spain between 2004 and 2008 were analyzed. Five BMI z score trajectories from birth to age 4 years were identified by using latent class growth analysis. Multinomial regression assessed the associations between maternal metabolic parameters and offspring's BMI trajectories.Results: Children in the reference BMI trajectory had average size at birth followed by a slower BMI gain. Maternal prepregnancy obesity was associated with trajectories of accelerated BMI gain departing from either higher (relative risk ratio [RRR] = 1.77; 95% CI: 1.07-2.91) or lower size at birth (RRR = 1.91; 95% CI: 1.17-3.12). Gestational weight gain (GWG) above clinical guidelines was associated with a trajectory of higher birth size followed by accelerated BMI gain (RRR = 2.14; 95% CI: 1.53-2.97). Maternal serum triglycerides were negatively associated with BMI trajectories departing from lower birth sizes. Gestational diabetes, maternal serum cholesterol, and C-reactive protein were unrelated to children's BMI trajectories.Conclusions: Maternal prepregnancy obesity, GWG, and serum triglycerides are associated with longitudinal BMI trajectories in early childhood that may increase disease risk in later life. Health initiatives should promote healthy weight status before and during pregnancy to improve maternal and child health. [ABSTRACT FROM AUTHOR]

Published
2018
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76. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Author

McKay, James D., Hung, Rayjean J., Han, Younghun, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil E., Johansson, Mattias, Xiao, Xiangjun, Li, Yafang, Byun, Jinyoung, Dunning, Alison, Pooley, Karen A., Qian, David C., Ji, Xuemei, Liu, Geoffrey, Timofeeva, Maria N., Bojesen, Stig E., Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier Alberto, Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher A., Wilkens, Lynne R., Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Henricus F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer A., Barnett, Matt P., Chen, Chu, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brüske, Irene, Wichmann, H-Erich, Manz, Judith, Muley, Thomas R., Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A., Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Joubert, Philippe, Lamontagne, Maxime, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Kachuri, Linda, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Rafnar, Thorunn, Thorgeirsson, Thorgeir E., Reginsson, Gunnar W., Stefansson, Kari, Hancock, Dana B., Bierut, Laura J., Spitz, Margaret R., Gaddis, Nathan C., Lutz, Sharon M., Gu, Fangyi, Johnson, Eric O., Kamal, Ahsan, Pikielny, Claudio, Zhu, Dakai, Lindström, Sara, Jiang, Xia, Tyndale, Rachel F., Chenevix-Trench, Georgia, Beesley, Jonathan, Bossé, Yohan, Chanock, Stephen, Brennan, Paul, Landi, Maria Teresa, Amos, Christopher I., McKay, James D., Hung, Rayjean J., Han, Younghun, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C., Caporaso, Neil E., Johansson, Mattias, Xiao, Xiangjun, Li, Yafang, Byun, Jinyoung, Dunning, Alison, Pooley, Karen A., Qian, David C., Ji, Xuemei, Liu, Geoffrey, Timofeeva, Maria N., Bojesen, Stig E., Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C., Bush, William S., Tardon, Adonina, Rennert, Gad, Teare, M. Dawn, Field, John K., Kiemeney, Lambertus A., Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B., Andrew, Angeline S., Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier Alberto, Pesatori, Angela C., Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S., Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher A., Wilkens, Lynne R., Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Henricus F. M., Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P. A., Marcus, Michael W., Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C., Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer A., Barnett, Matt P., Chen, Chu, Goodman, Gary E., Cox, Angela, Taylor, Fiona, Woll, Penella, Brüske, Irene, Wichmann, H-Erich, Manz, Judith, Muley, Thomas R., Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A., Tsao, Ming-Sound, Arnold, Susanne M., Haura, Eric B., Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M., Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J., Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard S., McLaughlin, John, Stevens, Victoria L., Joubert, Philippe, Lamontagne, Maxime, Nickle, David C., Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Kachuri, Linda, Artigas, Maria Soler, Tobin, Martin D., Wain, Louise V., Rafnar, Thorunn, Thorgeirsson, Thorgeir E., Reginsson, Gunnar W., Stefansson, Kari, Hancock, Dana B., Bierut, Laura J., Spitz, Margaret R., Gaddis, Nathan C., Lutz, Sharon M., Gu, Fangyi, Johnson, Eric O., Kamal, Ahsan, Pikielny, Claudio, Zhu, Dakai, Lindström, Sara, Jiang, Xia, Tyndale, Rachel F., Chenevix-Trench, Georgia, Beesley, Jonathan, Bossé, Yohan, Chanock, Stephen, Brennan, Paul, Landi, Maria Teresa, and Amos, Christopher I.

Abstract

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.

Published
2017
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77. Lifelong Residential Exposure to Green Space and Attention: A Population- based Prospective Study

Author

Dadvand, Payam, Tischer, Christina, Estarlich, Marisa, Llop, Sabrina, Dalmau- Bueno, Albert, Lopez-Vicente, Monica, Valentin, Antonia, de Keijzer, Carmen, Fernandez-Somoano, Ana, Lertxundi, Nerea, Rodriguez-Dehli, Cristina, Gascon, Mireia, Guxens, Monica, Zugna, Daniela, Basagana, Xavier, Nieuwenhuijsen, Mark J., Ibarluzea, Jesus, Ballester, Ferran, and Sunyer, Jordi

Subjects
Child development -- Health aspects -- Environmental aspects, Green design -- Influence, Environmental research, Environmental issues, Health
Abstract

BACKGROUND: Natural environments, including green spaces, may have beneficial impacts on brain development. However, longitudinal evidence of an association between long-term exposure to green spaces and cognitive development (including attention) in children is limited. OBJECTIVES: We evaluated the association between lifelong residential exposure to green space and attention during preschool and early primary school years. METHODS: This longitudinal study was based on data from two well-established population-based birth cohorts in Spain. We assessed lifelong exposure to residential surrounding greenness and tree cover as the average of satellite- based normalized difference vegetation index and vegetation continuous fields, respectively, surrounding the child's residential addresses at birth, 4- 5 y, and 7 y. Attention was characterized using two computerbased tests: Conners' Kiddie Continuous Performance Test (K-CPT) at 4-5 y (n = 888) and Attentional Network Task (ANT) at 7 y (n = 987). We used adjusted mixed effects models with cohort random effects to estimate associations between exposure to greenness and attention at ages 4-5 and 7 y. RESULTS: Higher lifelong residential surrounding greenness was associated with fewer K-CPT omission errors and lower K-CPT hit reaction timestandard error (HRT-SE) at 4-5 y and lower ANT HRT-SE at 7 y, consistent with better attention. This exposure was not associated with K-CPT commission errors or with ANT omission or commission errors. Associations with residential surrounding tree cover also were close to the null, or were negative (for ANT HRT-SE) but not statistically significant. CONCLUSION: Exposure to residential surrounding greenness was associated with better scores on tests of attention at 4-5 y and 7 y of age in our longitudinal cohort. https://doi.org/10.1289/EHP694, Introduction It has been proposed that exposure to natural environments, which include green spaces, is important for normal neurodevelopment (Kahn and Kellert 2002; Kellert 2005). Natural environments provide children with [...]

Published
2017
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78. Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development Six European Birth Cohorts

Author

Guxens, Monica Garcia-Esteban, Raquel Giorgis-Allemand, Lise and Forns, Joan Badaloni, Chiara Ballester, Ferran Beelen, Rob and Cesaroni, Giulia Chatzi, Leda de Agostini, Maria de Nazelle, Audrey Eeftens, Marloes Fernandez, Mariana F. and Fernandez-Somoano, Ana Forastiere, Francesco Gehring, Ulrike and Ghassabian, Akhgar Heude, Barbara Jaddoe, Vincent W. V. and Kluemper, Claudia Kogevinas, Manolis Kraemer, Ursula and Larroque, Beatrice Lertxundi, Aitana Lertxuni, Nerea Murcia, Mario Navel, Vladislav Nieuwenhuijsen, Mark Porta, Daniela and Ramos, Rosa Roumeliotaki, Theano Slama, Remy Sorensen, Mette Stephanou, Euripides G. Sugiri, Dorothea Tardon, Adonina Tiemeier, Henning Tiesler, Carla M. T. Verhulst, Frank C. Vrijkotte, Tanja Wilhelm, Michael Brunekreef, Bert and Pershagen, Goeran Sunyer, Jordi

Abstract

Background: Accumulating evidence from laboratory animal and human studies suggests that air pollution exposure during pregnancy affects cognitive and psychomotor development in childhood. Methods: We analyzed data from 6 European population-based birth cohorts-GENERATI ON R (The Netherlands), DUISBURG (Germany), EDEN (France), GASPII (Italy), RHEA (Greece), and INMA (Spain)-that recruited mother-infant pairs from 1997 to 2008. Air pollution levels-nitrogen oxides (NO2, NOx) in all regions and particulate matter (PM) with diameters of

Published
2014

79. Dietary Intake of Trans Fatty Acids in Children Aged 4–5 in Spain: The INMA Cohort Study

Author

Scholz, Alexander, primary, Gimenez-Monzo, Daniel, additional, Navarrete-Muñoz, Eva, additional, Garcia-de-la-Hera, Manuela, additional, Fernandez-Somoano, Ana, additional, Tardon, Adonina, additional, Santa Marina, Loreto, additional, Irazabal, Amaia, additional, Romaguera, Dora, additional, Guxens, Mònica, additional, Julvez, Jordi, additional, Llop, Sabrina, additional, Lopez-Espinosa, Maria-Jose, additional, and Vioque, Jesus, additional

Published
2016
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81. Ambient air pollution and low birthweight: a European cohort study (ESCAPE)

Author

Pedersen, Marie Giorgis-Allemand, Lise Bernard, Claire and Aguilera, Inmaculada Andersen, Anne-Marie Nybo Ballester, Ferran and Beelen, Rob M. J. Chatzi, Leda Cirach, Marta and Danileviciute, Asta Dedele, Audrius van Eijsden, Manon and Estarlich, Marisa Fernandez-Somoano, Ana Fernandez, Mariana F. and Forastiere, Francesco Gehring, Ulrike Grazuleviciene, Regina and Gruzieva, Olena Heude, Barbara Hoek, Gerard de Hoogh, Kees van den Hooven, Edith H. Haberg, Siri E. Jaddoe, Vincent W. V. Kluemper, Claudia Korek, Michal Kraemer, Ursula Lerchundi, Aitana Lepeule, Johanna Nafstad, Per and Nystad, Wenche Patelarou, Evridiki Porta, Daniela Postma, Dirkje Raaschou-Nielsen, Ole Rudnai, Peter Sunyer, Jordi and Stephanou, Euripides Sorensen, Mette Thiering, Elisabeth and Tuffnell, Derek Varro, Mihaly J. Vrijkotte, Tanja G. M. and Wijga, Alet Wilhelm, Michael Wright, John Nieuwenhuijsen, Mark J. Pershagen, Goeran Brunekreef, Bert Kogevinas, Manolis Slama, Remy

Abstract

Background Ambient air pollution has been associated with restricted fetal growth, which is linked with adverse respiratory health in childhood. We assessed the effect of maternal exposure to low concentrations of ambient air pollution on birthweight. Methods We pooled data from 14 population-based mother-child cohort studies in 12 European countries. Overall, the study population included 74 178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight

Published
2013

82. European Birth Cohorts for Environmental Health Research

Author

Vrijheid, Martine Casas, Maribel Bergstrom, Anna Carmichael, Amanda Cordier, Sylvaine Eggesbo, Merete Eller, Esben and Fantini, Maria P. Fernandez, Mariana F. Fernandez-Somoano, Ana and Gehring, Ulrike Grazuleviciene, Regina Hohmann, Cynthia and Karvonen, Anne M. Keil, Thomas Kogevinas, Manolis Koppen, Gudrun Kraemer, Ursula Kuehni, Claudia E. Magnus, Per and Majewska, Renata Andersen, Anne-Marie Nybo Patelarou, Evridiki and Petersen, Maria Skaalum Pierik, Frank H. Polanska, Kinga and Porta, Daniela Richiardi, Lorenzo Santos, Ana Cristina and Slama, Remy Sram, Radim J. Thijs, Care Tischer, Christina and Toft, Gunnar Trnovec, Tomas Vandentorren, Stephanie and Vrijkotte, Tanja G. M. Wilhelm, Michael Wright, John and Nieuwenhuijsen, Mark

Abstract

BACKGROUND: Many pregnancy and birth cohort studies investigate the health effects of early-life environmental contaminant exposure. An overview of existing studies and their data is needed to improve collaboration, harmonization, and future project planning. OBJECTIVES: Our goal was to create a comprehensive overview of European birth cohorts with environmental exposure data. METHODS: Birth cohort studies were included if they a) collected data on at least one environmental exposure, b) started enrollment during pregnancy or at birth, c) included at least one follow-up point after birth, d) included at least 200 mother-child pairs, and e) were based in a European country. A questionnaire collected information on basic protocol details and exposure and health outcome assessments, including specific contaminants, methods and samples, timing, and number of subjects. A full inventory can be searched on www.birthcohortsenrieco.net. RESULTS: Questionnaires were completed by 37 cohort studies of > 350,000 mother-child pairs in 19 European countries. Only three cohorts did not participate. All cohorts collected biological specimens of children or parents. Many cohorts collected information on passive smoking (n = 36), maternal occupation (n = 33), outdoor air pollution (n = 27), and allergens/biological organisms (n = 27). Fewer cohorts (n = 12-19) collected information on water contamination, ionizing or nonionizing radiation exposures, noise, metals, persistent organic pollutants, or other pollutants. All cohorts have information on birth outcomes; nearly all on asthma, allergies, childhood growth and obesity; and 26 collected information on child neurodevelopment. CONCLUSION: Combining forces in this field will yield more efficient and conclusive studies and ultimately improve causal inference. This impressive resource of existing birth cohort data could form the basis for longer-term and worldwide coordination of research on environment and child health.

Published
2012

86. Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts

Author

Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Guxens, Monica, Garcia-Esteban, Raquel, Giorgis-Allemand, Lise, Forns, Joan, Badaloni, Chiara, Ballester, Ferran, Beelen, Rob, Cesaroni, Giulia, Chatzi, Leda, de Agostini, Maria, de Nazelle, Audrey, Eeftens, Marloes, Fernandez, Mariana F., Fernandez-Somoano, Ana, Forastiere, Francesco, Gehring, Ulrike, Ghassabian, Akhgar, Heude, Barbara, Jaddoe, Vincent W. V., Kluemper, Claudia, Kogevinas, Manolis, Kraemer, Ursula, Larroque, Beatrice, Lertxundi, Aitana, Lertxuni, Nerea, Murcia, Mario, Navel, Vladislav, Nieuwenhuijsen, Mark, Porta, Daniela, Ramos, Rosa, Roumeliotaki, Theano, Slama, Remy, Sorensen, Mette, Stephanou, Euripides G., Sugiri, Dorothea, Tardon, Adonina, Tiemeier, Henning, Tiesler, Carla M. T., Verhulst, Frank C., Vrijkotte, Tanja, Wilhelm, Michael, Brunekreef, Bert, Pershagen, Goeran, Sunyer, Jordi, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Guxens, Monica, Garcia-Esteban, Raquel, Giorgis-Allemand, Lise, Forns, Joan, Badaloni, Chiara, Ballester, Ferran, Beelen, Rob, Cesaroni, Giulia, Chatzi, Leda, de Agostini, Maria, de Nazelle, Audrey, Eeftens, Marloes, Fernandez, Mariana F., Fernandez-Somoano, Ana, Forastiere, Francesco, Gehring, Ulrike, Ghassabian, Akhgar, Heude, Barbara, Jaddoe, Vincent W. V., Kluemper, Claudia, Kogevinas, Manolis, Kraemer, Ursula, Larroque, Beatrice, Lertxundi, Aitana, Lertxuni, Nerea, Murcia, Mario, Navel, Vladislav, Nieuwenhuijsen, Mark, Porta, Daniela, Ramos, Rosa, Roumeliotaki, Theano, Slama, Remy, Sorensen, Mette, Stephanou, Euripides G., Sugiri, Dorothea, Tardon, Adonina, Tiemeier, Henning, Tiesler, Carla M. T., Verhulst, Frank C., Vrijkotte, Tanja, Wilhelm, Michael, Brunekreef, Bert, Pershagen, Goeran, and Sunyer, Jordi

Published
2014

89. Folic Acid Supplements During Pregnancy and Child Psychomotor Development After the First Year of Life

Author

Valera-Gran, Desirée, primary, García de la Hera, Manuela, additional, Navarrete-Muñoz, Eva María, additional, Fernandez-Somoano, Ana, additional, Tardón, Adonina, additional, Julvez, Jordi, additional, Forns, Joan, additional, Lertxundi, Nerea, additional, Ibarluzea, Jesús María, additional, Murcia, Mario, additional, Rebagliato, Marisa, additional, and Vioque, Jesús, additional

Published
2014
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92. Indoor Air Pollution From Gas Cooking and Infant Neurodevelopment

Author

Vrijheid, Martine, primary, Martinez, David, additional, Aguilera, Inma, additional, Bustamante, Mariona, additional, Ballester, Ferran, additional, Estarlich, Marisa, additional, Fernandez-Somoano, Ana, additional, Guxens, Mònica, additional, Lertxundi, Nerea, additional, Martinez, M. Dolores, additional, Tardon, Adonina, additional, and Sunyer, Jordi, additional

Published
2012
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93. Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study

Author

Casas, Maribel, Forns, Joan, Martínez, David, Guxens, Mònica, Fernandez-Somoano, Ana, Ibarluzea, Jesus, Lertxundi, Nerea, Murcia, Mario, Rebagliato, Marisa, Tardon, Adonina, Sunyer, Jordi, and Vrijheid, Martine

Abstract

BackgroundMaternal pre-pregnancy obesity may impair infant neuropsychological development, but it is unclear whether intrauterine or confounding factors drive this association.MethodsWe assessed whether maternal pre-pregnancy obesity was associated with neuropsychological development in 1,827 Spanish children. At 5 years, cognitive and psychomotor development was assessed using McCarthy Scales of Children’s Abilities, attention deficit hyperactivity disorder (ADHD) symptoms using the Criteria of Diagnostic and Statistical Manual of Mental Disorders, and autism spectrum disorder symptoms using the Childhood Asperger Syndrome Test. Models were adjusted for sociodemographic factors and maternal intelligence quotient. We used paternal obesity as negative control exposure as it involves the same source of confounding than maternal obesity.ResultsThe percentage of obese mothers and fathers was 8% and 12%, respectively. In unadjusted models, children of obese mothers had lower scores than children of normal weight mothers in all McCarthy subscales. After adjustment, only the verbal subscale remained statistically significantly reduced (β: −2.8; 95% confidence interval: −5.3, −0.2). No associations were observed among obese fathers. Maternal and paternal obesity were associated with an increase in ADHD-related symptoms. Parental obesity was not associated with autism symptoms.ConclusionMaternal pre-pregnancy obesity was associated with a reduction in offspring verbal scores at pre-school age.

Published
2017
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94. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Author

McKay, James D, Hung, Rayjean J, Han, Younghun, Zong, Xuchen, Carreras-Torres, Robert, Christiani, David C, Caporaso, Neil E, Johansson, Mattias, Xiao, Xiangjun, Li, Yafang, Byun, Jinyoung, Dunning, Alison, Pooley, Karen A, Qian, David C, Ji, Xuemei, Liu, Geoffrey, Timofeeva, Maria N, Bojesen, Stig E, Wu, Xifeng, Le Marchand, Loic, Albanes, Demetrios, Bickeböller, Heike, Aldrich, Melinda C, Bush, William S, Tardon, Adonina, Rennert, Gad, Teare, M Dawn, Field, John K, Kiemeney, Lambertus A, Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B, Andrew, Angeline S, Shen, Hongbing, Hong, Yun-Chul, Yuan, Jian-Min, Bertazzi, Pier Alberto, Pesatori, Angela C, Ye, Yuanqing, Diao, Nancy, Su, Li, Zhang, Ruyang, Brhane, Yonathan, Leighl, Natasha, Johansen, Jakob S, Mellemgaard, Anders, Saliba, Walid, Haiman, Christopher A, Wilkens, Lynne R, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, van der Heijden, Henricus F M, Kim, Jin Hee, Dai, Juncheng, Hu, Zhibin, Davies, Michael P A, Marcus, Michael W, Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C, Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Doherty, Jennifer A, Barnett, Matt P, Chen, Chu, Goodman, Gary E, Cox, Angela, Taylor, Fiona, Woll, Penella, Brüske, Irene, Wichmann, H-Erich, Manz, Judith, Muley, Thomas R, Risch, Angela, Rosenberger, Albert, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A, Tsao, Ming-Sound, Arnold, Susanne M, Haura, Eric B, Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeria, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M, Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J, Butler, Lesley M, Koh, Woon-Puay, Gao, Yu-Tang, Houlston, Richard S, McLaughlin, John, Stevens, Victoria L, Joubert, Philippe, Lamontagne, Maxime, Nickle, David C, Obeidat, Ma'en, Timens, Wim, Zhu, Bin, Song, Lei, Kachuri, Linda, Artigas, María Soler, Tobin, Martin D, Wain, Louise V, Rafnar, Thorunn, Thorgeirsson, Thorgeir E, Reginsson, Gunnar W, Stefansson, Kari, Hancock, Dana B, Bierut, Laura J, Spitz, Margaret R, Gaddis, Nathan C, Lutz, Sharon M, Gu, Fangyi, Johnson, Eric O, Kamal, Ahsan, Pikielny, Claudio, Zhu, Dakai, Lindströem, Sara, Jiang, Xia, Tyndale, Rachel F, Chenevix-Trench, Georgia, Beesley, Jonathan, Bossé, Yohan, Chanock, Stephen, Brennan, Paul, Landi, Maria Teresa, and Amos, Christopher I

Abstract

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.

Published
2017
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