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This study is part of a prospective study, which started in the year 2000, to monitor the health status of the population of the city of Parona, a previously agricultural area which has been transformed in a prevalently industrial area. This is the second phase of a project regarding the epidemiological surveillance of this population. The aim of the project was to detect changes in the health status of the population, particularly with regard to respiratory diseases associated with air pollution. Data was collected through the use of a questionnaire and a spirometry test. A control group was used in both parts of the study; control subjects lived in the city of Rovescala. In total 1484 subjects were invited by letter to participate and 399 (27%) accepted. The mean age of participants was 48 years (range 15-74 years). Only 149/399 (37%) subjects had participated in part 1 of the study. No significant changes were found in respiratory symptoms during the period considered. Three hundred eighty six subjects underwent spirometry testing, 36 of which (9%) were found to have an abnormal result. A moderately increased prevalence of obstructive airway signs on spirometry was registered in female participants, with respect to the year 2000 (5.9% vs 2.6%). On the other hand, the prevalence of restrictive signs remained similar in both males (1,7% vs 2,4%) and females (2% vs 1,5%). The spirometry changes detected in the149 subjects (65 male and 84 female) who participated in both parts of the study (parts 1 and 2) were most likely age-related. No significant differences were found with respect to the control group, although the prevalence of obstructive signs among males was greater in the city of Parona (9.2% vs 6.9%.

to describe the prevalence of smokers among 13- 18-years-old students in Lombardy and to evaluate some related motives.a survey has been carried out with anonymous questionnaires, distributed at the beginning of the school year 2005-2006.the study involved 3,593 classes of the third year of middle school and 2,893 classes of the second and the fifth year of high school, sampled among all the schools of Lombardy.the study interested 11,494 students aged either 13, 15 or 18.the prevalence of habitual smokers was 6%, 26.5% and 33.2%.a higher percentage of smokers report to have low school performances and to receive more than 15 euros as weekly tip. The number of smokers among family components and friends always appears higher for smoker students. Unemployed fathers and working mothers were higher among smokers. Both parents of smoker students have a lower educational level.an organized and systematic regional surveillance could highlight some characteristics of smoking habit among young students useful to set health education programs and to evaluate the efficacy of interventions already being carried out. Besides, it could enhance the awareness of the problem.

We present the FP420 R&D project, which has been studying the key aspects of the development and installation of a silicon tracker and fast-timing detectors in the LHC tunnel at 420 m from the interaction points of the ATLAS and CMS experiments. These detectors would measure precisely very forward protons in conjunction with the corresponding central detectors as a means to study Standard Model (SM) physics, and to search for and characterise New Physics signals. This report includes a detailed description of the physics case for the detector and, in particular, for the measurement of Central Exclusive Production, pp --> p + phi + p, in which the outgoing protons remain intact and the central system phi may be a single particle such as a SM or MSSM Higgs boson. Other physics topics discussed are gamma-gamma and gamma-p interactions, and diffractive processes. The report includes a detailed study of the trigger strategy, acceptance, reconstruction efficiencies, and expected yields for a particular p p --> p H p measurement with Higgs boson decay in the b-bbar mode. The document also describes the detector acceptance as given by the LHC beam optics between the interaction points and the FP420 location, the machine backgrounds, the new proposed connection cryostat and the moving ("Hamburg") beam-pipe at 420 m, and the radio-frequency impact of the design on the LHC. The last part of the document is devoted to a description of the 3D silicon sensors and associated tracking performances, the design of two fast-timing detectors capable of accurate vertex reconstruction for background rejection at high-luminosities, and the detector alignment and calibration strategy., 178 pages, 128 figures. Updated Timing section. Figures compressed to marginal resolution due to arxiv.org file size requirements. A higher quality document accessible at http://www.fp420.com/papers.html

to analyze smoking habits, opinions on smoking, curriculum and smoking prevention activities carried out by general practitioners in the Lombardy Region (Northern Italy).between 2000 and 2002 a questionnaire about tobacco smoke retrieved from the European Project "GPs Empowerment" has been sent to 5348 general practitioners in the Lombardy Region. The questionnaire focuses on the difference of opinions and activity between smoking and non-smoking physicians. We analyzed 3571 questionnaires voluntarily filled.The prevalence of smokers among the general practitioners in the Lombardy Region was 22.3% (CI95% 21-24%), (M: 24.2%, CI 95% 22-26% and F: 17.8%, CI 95% 15-20%). Physicians could play a role in the prevention of tobacco: 98.7% (CI 95% 98-99%) agree about the effectiveness of counseling but only 65.6% (CI95% 64-67%) regularly counsel their patients about smoking-related diseases and quitting. In this paper, we estimated that 963% (CI95% 96-97%) non smoking GPs consider counseling useful for their patients vs 92.6% (CI 95% 91-94%) of smoking physicians (p0. 001); GPs who think to represent a model for people are more frequent among non smokers (97.5%, CI95% 97-98% vs 89.3%, CI 95% 87-91%;p0.001). Those who discuss with their patients about tobacco addiction and cessation are 68.9% (CI95% 67-71%) among non smokers vs 53.4% (CI 95% 50-54%) among smokers (p0.001). Finally 67% (CI 95 % 65-69%) interviewed physicians lacked a specific training in smoking prevention. Among them, 87.4%(CI 95% 86-89%) would attend the courses.this finding could be useful for planning or enhancing activities aimed at improving preventive and cessation methods.

Measuring the beam transverse emittance is fundamental in every accelerator, in particular for colliders, where its precise determination is essential to maximize the luminosity and thus the performance of the colliding beams. Synchrotron Radiation (SR) is a versatile tool for non-destructive beam diagnostics, since its characteristics are closely related to those of the source beam. At CERN, being the only available diagnostics at high beam intensity and energy, SR monitors are exploited as the proton beam size monitor of the two higher energy machines, the Super Proton Synchrotron (SPS) and the Large Hadron Collider (LHC). The thesis work documented in this report focused on the design, development, characterization and optimization of these beam size monitors. Such studies were based on a comprehensive set of theoretical calculations, numerical simulations and experiments.A powerful simulation tool has been developed combining conventional softwares for SR simulation and optics design, thus allowing the description of an SR monitor from its source up to the detector. The simulations were confirmed by direct observations, and a detailed performance studies of the operational SR imaging monitor in the LHC, where different techniques for experimentally validating the system were applied, such as cross-calibrations with the wire scanners at low intensity (that are considered as a reference) and direct comparison with beam sizes de-convoluted from the LHC luminosity measurements.In 2015, the beam sizes to be measured with the further increase of the LHC beam energy to 7 TeV will decrease down to ∼190 μm. In these conditions, the SR imaging technique was found at its limits of applicability since the error on the beam size determination is proportional to the ratio of the system resolution and the measured beam size. Therefore, various solutions were probed to improve the system’s performance such as the choice of one light polarization, the reduction of depth of field effect and the reduction of the imaging wavelength down to 250 nm.In parallel to reducing the diffraction contribution to the resolution broadening, the extraction mirror, found as the main sources of aberrations in the system was redesigned. Its failure was caused by the EM coupling with the beam’s fields that led to overheating and deterioration of the coating. A new system’s geometry featuring a smoother transition in the beam pipe was qualified in terms of longitudinal coupling impedance via the stretched wire technique. A comparison with the older system was carried out and resulted in a reduction of the total power dissipated in the extraction system by at least a factor of four.A new, non-diffraction limited, SR-based monitor based on double slit interferometry was designed as well as an alternative method to the direct imaging. Its principle is based on the direct relation between the interferogram fringes visibility and the beam size.Since the beam emittance is the physical quantity of interest in the performance analysis of the LHC, determining the optical functions at the SR monitors is as relevant as measuring the beam size. The “K-modulation” method for the optical function determination was applied for the first time in the LHC IR4, where most of the profile monitors sit. The βs at the quadrupoles were measured and via two different propagation algorithms the βs at the BSRT and the WS were obtained reducing significantly the uncertainty at the monitors location., La mesure de l’émittance transverse du faisceau est fondamentale pour tous les accélérateurs, et en particulier pour les collisionneurs, son évaluation precise étant essentielle pour maximiser la luminosité et ainsi la performance des faisceaux de collision.Le rayonnement synchrotron (SR) est un outil polyvalent pour le diagnostic non-destructif de faisceau, exploité au CERN pour mesurer la taille des faisceaux de protons des deux machines du complexe dont l’énergie est la plus élevée, le SPS et le LHC où l’intensité du faisceau ne permet plus les techniques invasives.Le travail de thèse documenté dans ce rapport s’est concentré sur la conception, le développement, la caractérisation et l’optimisation des moniteurs de taille de faisceau basés sur le SR. Cette étude est fondée sur un ensemble de calculs théoriques, de simulation numériques et d’expériences conduite au sein des laboratoires et accélérateurs du CERN. Un outil de simulation puissant a été développé, combinant des logiciels classiques de simulation de SR et de propagation optique, permettant ainsi la caractérisation complète d’un moniteur SR de la source jusqu’au détecteur.La source SR a pu être entièrement caractérisée par cette technique, puis les résultats validés par observation directe et par la calibration à basse énergie basée sur les mesures effectuées avec les wire-scanners (WS), qui sont la référence en terme de mesure de taille de faisceau, ou telles que la comparaison directe avec la taille des faisceaux obtenue par déconvolution de la luminosité instantanée du LHC.Avec l’augmentation de l’énergie dans le LHC (7TeV), le faisceau verra sa taille diminuer jusqu’à atteindre la limite de la technique d’imagerie du SR. Ainsi, plusieurs solutions ont été investiguées afin d’améliorer la performance du système: la sélection d’une des deux polarisations du SR, la réduction des effets liés à la profondeur de champ par l’utilisation de fentes optiques et l’utilisation d’une longueur d’onde réduite à 250 nm.En parallèle à l’effort de réduction de la diffraction optique, le miroir d’extraction du SR qui s’était avéré être la source principale des aberrations du système a été entièrement reconçu. En effet, la détérioration du miroir a été causée par son couplage EM avec les champs du faisceau, ce qui a conduit à une surchauffe du coating et à sa dégradation. Une nouvelle géométrie de miroir et de son support permettant une douce transition en termes de couplage d’impédance longitudinale dans le beam pipe a été définie et caractérisée par la technique dite du “streched wire”. Egalement, comme méthode alternative à l’imagerie directe, un nouveau moniteur basé sur la technique d’interférométrie à deux fentes du SR, non limité par la diffraction, a également été développé. Le principe de cette méthode est basé sur la relation directe entre la visibilité des franges d’interférence et la taille de faisceau.Comme l’emittance du faisceau est la donnée d’intérêt pour la performance du LHC, il est aussi important de caractériser avec précision l’optique du LHC à la source du SR. Dans ce but, la méthode “K-modulation” a été utilisée pour la première fois au LHC en IR4. Les β ont été mesurés à l’emplacement de tous les quadrupoles et ont été évalués via deux algorithmes de propagation différents au BSRT et au WS.