24,641 results on '"Fedele, A"'
Search Results
52. Real-time two-axis control of a spin qubit
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Berritta, Fabrizio, Rasmussen, Torbjørn, Krzywda, Jan A., van der Heijden, Joost, Fedele, Federico, Fallahi, Saeed, Gardner, Geoffrey C., Manfra, Michael J., van Nieuwenburg, Evert, Danon, Jeroen, Chatterjee, Anasua, and Kuemmeth, Ferdinand
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- 2024
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53. Model independent bounds on heavy sterile neutrinos from the angular distribution of B → D* ℓν decays
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Florian U. Bernlochner, Marco Fedele, Tim Kretz, Ulrich Nierste, and Markus T. Prim
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Bottom Quarks ,Semi-Leptonic Decays ,Sterile or Heavy Neutrinos ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract In this paper we study the bounds that can be inferred on New Physics couplings to heavy sterile neutrinos N from the recent measurements performed by the Belle collaboration of the angular analysis of B → D ∗ ℓ ν ¯ ℓ $$ B\to {D}^{\ast}\ell {\overline{\nu}}_{\ell } $$ decays, with ℓ = e, μ. Indeed, a sterile neutrino N may lead to competing B → D ∗ ℓ N ¯ $$ B\to {D}^{\ast}\ell \overline{N} $$ decays and Belle might have measured an incoherent sum of these two independent channels. After reviewing the theoretical formalism required to describe this phenomenon in full generality, we first perform a bump hunt in the M miss 2 $$ {M}_{\textrm{miss}}^2 $$ Belle distribution to search for evidences of an additional massive neutrino. We found in such a way a small hint at M miss 2 $$ {M}_{\textrm{miss}}^2 $$ ∼ (354 MeV)2. However, the Belle angular analysis is sensitive to N masses up to O $$ \mathcal{O} $$ (50 MeV), preventing us to further inspect this hint. Nevertheless, we study the potential impact of this additional channel in the allowed mass range on the measured angular distributions and extract model-independent bounds on the new-physics couplings which could mediate such an interaction. In particular, in the mass window here inspected, we obtain the most stringent bounds for vector and left-handed scalar operators to date.
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- 2025
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54. Estimating pros and cons of statistical downscaling based on EQM bias adjustment as a complementary method to dynamical downscaling
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Alfredo Reder, Giusy Fedele, Ilenia Manco, and Paola Mercogliano
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Empirical quantile mapping (EQM) ,Climate reanalysis ,Temperature and precipitation downscaling ,Performance evaluation ,Training period variability ,Medicine ,Science - Abstract
Abstract The increasing availability of coarse-scale climate simulations and the need for ready-to-use high-resolution variables drive the climate community to the challenge of reducing computational resources and time for downscaling purposes. To this end, statistical downscaling is gaining interest as a potential strategy for integrating high-resolution climate information obtained through dynamical downscaling over limited years, providing a clear understanding of the gains and losses in combining dynamical and statistical downscaling. In this regard, several questions can be raised: (i) what is the performance of statistical downscaling, assuming dynamical downscaling as a reference over a shared time window; (ii) how much the performance of statistical downscaling is affected by changes in the number of years available for training; (iii) how does the climate normal considered for the training affect the predictions. This study addresses these issues by applying a statistical downscaling procedure based on the empirical quantile mapping bias adjustment, obtaining finer-resolution climate variables. This procedure was adopted in order to downscale temperature and precipitation from ERA5 climate reanalysis, having as reference both for training and validation, the respective variables obtained through the dynamical downscaling of ERA5 over Italy for about 30 years. The availability of such a long simulation allows us to define several long time windows, used to calibrate the statistical relationships and evaluate the performance of statistical downscaling versus dynamical downscaling over a shared blind prediction period, taking advantage of a set of spatial and temporal metrics. The study shows that (i) the statistical downscaling successfully represents mean values and extremes of temperature and precipitation; (ii) its performance remains satisfactory regardless of the number of years used as training; (iii) the shorter is the time window considered for the training, the higher is the sensitivity to changes in the time interval due to the inter-annual variability. Nevertheless, the performance deviations are somehow not so remarkable.
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- 2025
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55. Mapping and ranking outcomes for the evaluation of seasonal influenza vaccine efficacy and effectiveness: a delphi study
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Chiara de Waure, Elisabetta Alti, Vincenzo Baldo, Paolo Bonanni, Michele Conversano, Alberto Fedele, Giovanni Gabutti, Roberto Ieraci, Francesco Landi, Raffaele Landolfi, Andrea Orsi, Caterina Rizzo, Alessandro Rossi, Alberto Villani, Francesco Vitale, and Alexander Domnich
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Influenza ,influenza vaccines ,vaccine efficacy ,vaccine effectiveness ,outcome assessment ,Delphi method ,Internal medicine ,RC31-1245 - Abstract
Background Protection provided by seasonal influenza vaccination (SIV) may be measured against numerous outcomes, and their heterogeneity may hamper decision-making. The aim of this study was to explore outcomes used for estimation of SIV efficacy/effectiveness (VE) and obtain expert consensus on their importance.Research design and methods An umbrella review was first conducted to collect and map outcomes considered in systematic reviews of SIV VE. A Delphi study was then performed to reach expert convergence on the importance of single outcomes, measured on a 9-point Likert scale, in principal target groups, namely children, working-age adults, older adults, subjects with co-morbidities and pregnant women.Results The literature review identified 489 outcomes. Following data reduction, 20 outcomes were selected for the Delphi process. After two Delphi rounds and a final consensus meeting, convergence was reached. All 20 outcomes were judged to be important or critically important. More severe outcomes, such as influenza-related hospital encounters and mortality with or without laboratory confirmation, were generally top-ranked across all target groups (median scores ≥8 out of 9).Conclusions Rather than focusing on laboratory-confirmed infection per se, experimental and observational VE studies should include more severe influenza-related outcomes because they are expected to exercise a greater impact on decision-making.
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- 2024
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56. Molecular findings and virological assessment of bladder papillomavirus infection in cattle
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Francesca De Falco, Anna Cutarelli, Francesca Luisa Fedele, Cornel Catoi, and Sante Roperto
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Bladder tumors ,bovine papillomavirus ,cattle ,droplet digital polymerase chain reaction (ddPCR) ,ovine papillomavirus ,Veterinary medicine ,SF600-1100 - Abstract
Bovine and ovine papillomaviruses (BPVs – OaPVs) are infectious agents that have an important role in bladder carcinogenesis of cattle. In an attempt to better understand territorial prevalence of papillomavirus genotypes and gain insights into their molecular pathway(s), a virological assessment of papillomavirus infection was performed on 52 bladder tumors in cattle using droplet digital polymerase chain reaction (ddPCR), an improved version of conventional PCR. ddPCR detected and quantified BPV DNA and mRNAs in all tumor samples, showing that these viruses play a determinant role in bovine bladder carcinogenesis. OaPV DNA and mRNA were detected and quantified in 45 bladder tumors. BPV14, BPV13, BPV2, OaPV2, OaPV1, and OaPV3 were the genotypes most closely related to bladder tumors. ddPCR quantified BPV1 and OaPV4 DNA and their transcripts less frequently. Western blot analysis revealed a significant overexpression of the phosphorylated platelet derived growth factor β receptor (PDGFβR) as well as the transcription factor E2F3, which modulate cell cycle progression in urothelial neoplasia. Furthermore, significant overexpression of calpain1, a Cys protease, was observed in bladder tumors related to BPVs alone and in BPV and OaPV coinfection. Calpain1 has been shown to play a role in producing free transcription factors of the E2F family, and molecular findings suggest that calpain family members work cooperatively to mutually regulate their protease activities in cattle bladder tumors. Altogether, these results showed territorial prevalence of BPV and OaPV genotypes and suggested that PDGFβR and the calpain system appeared to be molecular partners of both BPVs and OaPVs.
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- 2024
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57. Automated long-range compensation of an rf quantum dot sensor
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Hickie, Joseph, van Straaten, Barnaby, Fedele, Federico, Jirovec, Daniel, Ballabio, Andrea, Chrastina, Daniel, Isella, Giovanni, Katsaros, Georgios, and Ares, Natalia
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Charge sensing is a sensitive technique for probing quantum devices, of particular importance for spin qubit readout. To achieve good readout sensitivities, the proximity of the charge sensor to the device to be measured is a necessity. However, this proximity also means that the operation of the device affects, in turn, the sensor tuning and ultimately the readout sensitivity. We present an approach for compensating for this cross-talk effect allowing for the gate voltages of the measured device to be swept in a 1 V x 1 V window while maintaining a sensor configuration chosen by a Bayesian optimiser. Our algorithm is a key contribution to the suite of fully automated solutions required for the operation of large quantum device architectures.
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- 2023
58. Hydrodynamic regime and cold plasmas hit by short laser pulses
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Fiore, Gaetano, De Angelis, Monica, Fedele, Renato, Guerriero, Gabriele, and Jovanović, Dušan
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Physics - Plasma Physics ,Mathematical Physics ,34Cxx, 34C11, 70H40, 76Wxx - Abstract
We briefly report and elaborate on some conditions allowing a hydrodynamic description of the impact of a very short and arbitrarily intense laser pulse onto a cold plasma, as well as the localization of the first wave-breaking due to the plasma inhomogeneity. We use a recently developed fully relativistic plane model whereby we reduce the system of the Lorentz-Maxwell and continuity PDEs into a 1-parameter family of decoupled systems of non-autonomous Hamilton equations in dimension 1, with the light-like coordinate $\xi=ct\!-\!z$ replacing time $t$ as an independent variable. Apriori estimates on the Jacobian $\hat J$ of the change from Lagrangian to Eulerian coordinates in terms of the input data (initial density and pulse profile) are obtained applying Liapunov direct method to an associated family of pairs of ODEs; wave-breaking is pinpointed by the inequality $\hat J\le 0$. These results may help in drastically simplifying the study of extreme acceleration mechanisms of electrons, which have very important applications., Comment: 15 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:2207.11188
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- 2023
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59. Building pretorsion theories from torsion theories
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Campanini, Federico and Fedele, Francesca
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Mathematics - Category Theory ,Mathematics - Representation Theory - Abstract
Torsion theories play an important role in abelian categories and they have been widely studied in the last sixty years. In recent years, with the introduction of pretorsion theories, the definition has been extended to general (non-pointed) categories. Many examples have been investigated in several different contexts, such as topological spaces and topological groups, internal preorders, preordered groups, toposes, V-groups, crossed modules, etc. In this paper, we show that pretorsion theories naturally appear also in the "classical" framework, namely in abelian categories. We propose two ways of obtaining pretorsion theories starting from torsion theories. The first one uses "comparable" torsion theories, while the second one extends a torsion theory with a Serre subcategory. We also give a universal way of obtaining a torsion theory from a given pretorsion theory in additive categories. We conclude by providing several applications in module categories, internal groupoids, recollements and representation theory.
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- 2023
60. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
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Gastaldi, Simone, Rocca, Carmine, Gianquinto, Eleonora, Granieri, Maria Concetta, Boscaro, Valentina, Blua, Federica, Rolando, Barbara, Marini, Elisabetta, Gallicchio, Margherita, De Bartolo, Anna, Romeo, Naomi, Mazza, Rosa, Fedele, Francesco, Pagliaro, Pasquale, Penna, Claudia, Spyrakis, Francesca, Bertinaria, Massimo, and Angelone, Tommaso
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Physics - Biological Physics ,Physics - Medical Physics - Abstract
Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by replacing the central sulfonylurea moiety with different heterocycles. Computational studies evidenced that some of the designed compounds were able to maintain important interaction within the NACHT domain of the target protein similarly to the most active sulfonylurea-based NLRP3 inhibitors. Among the studied compounds, the 1,3,4-oxadiazol-2-one derivative 5 (INF200) showed the most promising results being able to prevent NLRP3-dependent pyroptosis triggered by LPS/ATP and LPS/MSU by 66.3 +/- 6.6% and 61.6 +/- 11.5% and to reduce IL-1\b{eta} release (35.5 +/- 8.8 % {\mu}M) at 10 {\mu}M in human macrophages. The selected compound INF200 (20 mg/kg/day) was then tested in an in vivo rat model of high-fat diet (HFD)-induced metaflammation to evaluate its beneficial cardiometabolic effects. INF200 significantly counteracted HFD-dependent "anthropometric" changes, improved glucose and lipid profiles, and attenuated systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). Hemodynamic evaluation on Langendorff model indicate that INF200 limited myocardial damage-dependent ischemia/reperfusion injury (IRI) by improving post-ischemic systolic recovery and attenuating cardiac contracture, infarct size, and LDH release, thus reversing the exacerbation of obesity-associated damage. Mechanistically, in post-ischemic hearts, IFN200 reduced IRI-dependent NLRP3 activation, inflammation, and oxidative stress. These results highlight the potential of the novel NLRP3 inhibitor, INF200, and its ability to reverse the unfavorable cardio-metabolic dysfunction associated with obesity.
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- 2023
61. Full L- and M-band high resolution spectroscopy of the S CrA binary disks with VLT-CRIRES+
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Grant, Sierra L., Bettoni, Giulio, Banzatti, Andrea, van Dishoeck, Ewine F., Brittain, Sean, Fedele, Davide, Henning, Thomas, Manara, Carlo, Semenov, Dmitry, and Whelan, Emma
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The Cryogenic IR echelle Spectrometer (CRIRES) instrument at the Very Large Telescope (VLT) was in operation from 2006 to 2014. Great strides in characterizing the inner regions of protoplanetary disks were made using CRIRES observations in the L- and M-band at this time. The upgraded instrument, CRIRES+, became available in 2021 and covers a larger wavelength range simultaneously. Here we present new CRIRES+ Science Verification data of the binary system S Coronae Australis (S CrA). We aim to characterize the upgraded CRIRES+ instrument for disk studies and provide new insight into the gas in the inner disk of the S CrA N and S systems. We analyze the CRIRES+ data taken in all available L- and M-band settings, providing spectral coverage from 2.9 to 5.5 $\mu$m. We detect emission from $^{12}$CO (v=1-0, v=2-1, and v=3-2), $^{13}$CO (v=1-0), hydrogen recombination lines, OH, and H$_2$O in the S CrA N disk. In the fainter S CrA S system, only the $^{12}$CO v=1-0 and the hydrogen recombination lines are detected. The $^{12}$CO v=1-0 emission in S CrA N and S shows two velocity components, a broad component coming from $\sim$0.1 au in S CrA N and $\sim$0.03 au in S CrA S and a narrow component coming from $\sim$3 au in S CrA N and $\sim$5 au in S CrA S. We fit local thermodynamic equilibrium slab models to the rotation diagrams of the two S CrA N velocity components and find that they have similar column densities ($\sim$1-7$\times$10$^{17}$ cm$^{-2}$), but that the broad component is coming from a hotter and narrower region. Two filter settings, M4211 and M4368, provide sufficient wavelength coverage for characterizing CO and H$_2$O at $\sim$5 $\mu$m, in particular covering low- and high-$J$ lines. CRIRES+ provides spectral coverage and resolution that are crucial complements to low-resolution observations, such as those with JWST, where multiple velocity components cannot be distinguished., Comment: 15 pages, 13 figures, accepted to A&A
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- 2023
62. lifex-ep: a robust and efficient software for cardiac electrophysiology simulations
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Africa, Pasquale C., Piersanti, Roberto, Regazzoni, Francesco, Bucelli, Michele, Salvador, Matteo, Fedele, Marco, Pagani, Stefano, Dede', Luca, and Quarteroni, Alfio
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Mathematics - Numerical Analysis - Abstract
Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors of various research teams, comprehensive and user-friendly software programs for cardiac simulations are still in the process of achieving full maturity within the scientific community. This work introduces lifex-ep, a publicly available software for numerical simulations of the electrophysiology activity of the cardiac muscle, under both physiological and pathological conditions. lifex-ep employs the monodomain equation to model the heart's electrical activity. It incorporates both phenomenological and second-generation ionic models. These models are discretized using the Finite Element method on tetrahedral or hexahedral meshes. Additionally, lifex-ep integrates the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, previously released in Africa et al., 2023, within lifex-fiber. This paper provides a concise overview of the mathematical models and numerical methods underlying lifex-ep, along with comprehensive implementation details and instructions for users. lifex-ep features exceptional parallel speedup, scaling efficiently when using up to thousands of cores, and its implementation has been verified against an established benchmark problem for computational electrophysiology. We showcase the key features of lifex-ep through various idealized and realistic simulations. lifex-ep offers a user-friendly and flexible interface. lifex-ep provides easy access to cardiac electrophysiology simulations for a wide user community. It offers a computational tool that integrates models and accurate methods for simulating cardiac electrophysiology within a high-performance framework, while maintaining a user-friendly interface.
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- 2023
63. Safety and effectiveness of cenobamate in down syndrome: a case report
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Corniello, Clarissa, Dono, Fedele, Evangelista, Giacomo, Cipollone, Sara, Consoli, Stefano, and Sensi, Stefano L.
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- 2025
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64. Predictable and unpredictable deviance detection in the human hippocampus and amygdala.
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Tzovara, Athina, Fedele, Tommaso, Sarnthein, Johannes, Ledergerber, Debora, Lin, Jack, and Knight, Robert
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amygdala ,auditory predictions ,deviance ,hippocampus ,intracranial EEG ,Humans ,Auditory Cortex ,Temporal Lobe ,Amygdala ,Brain ,Hippocampus ,Acoustic Stimulation ,Auditory Perception ,Evoked Potentials ,Auditory - Abstract
Our brains extract structure from the environment and form predictions given past experience. Predictive circuits have been identified in wide-spread cortical regions. However, the contribution of medial temporal structures in predictions remains under-explored. The hippocampus underlies sequence detection and is sensitive to novel stimuli, sufficient to gain access to memory, while the amygdala to novelty. Yet, their electrophysiological profiles in detecting predictable and unpredictable deviant auditory events remain unknown. Here, we hypothesized that the hippocampus would be sensitive to predictability, while the amygdala to unexpected deviance. We presented epileptic patients undergoing presurgical monitoring with standard and deviant sounds, in predictable or unpredictable contexts. Onsets of auditory responses and unpredictable deviance effects were detected earlier in the temporal cortex compared with the amygdala and hippocampus. Deviance effects in 1-20 Hz local field potentials were detected in the lateral temporal cortex, irrespective of predictability. The amygdala showed stronger deviance in the unpredictable context. Low-frequency deviance responses in the hippocampus (1-8 Hz) were observed in the predictable but not in the unpredictable context. Our results reveal a distributed network underlying the generation of auditory predictions and suggest that the neural basis of sensory predictions and prediction error signals needs to be extended.
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- 2024
65. Binary Bibraces and Applications to Cryptography
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Civino, Roberto and Fedele, Valerio
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- 2025
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66. First occurrence of a reproductive group of golden jackal (Canis aureus moreoticus) in a densely populated area south of the Po River (Italy)
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Travain, Tiziano, Fior, Emanuele, Bigotti, Giulia, Fedele, Pier Luigi, Lapini, Luca, Filonzi, Laura, Valsecchi, Paola, and Nonnis Marzano, Francesco
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- 2024
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67. On the effect of confounding in linear regression models: an approach based on the theory of quadratic forms
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Narcisi, Martina, Greco, Fedele, and Trivisano, Carlo
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- 2024
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68. Renormalisation group analysis of scalar Leptoquark couplings addressing flavour anomalies: emergence of lepton-flavour universality
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Fedele, Marco, Wuest, Felix, and Nierste, Ulrich
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
Leptoquarks with masses between 2 TeV and 50 TeV are commonly invoked to explain deviations between data and Standard-Model (SM) predictions of several observables in the decays $b\to c\tau \bar\nu$ and $b\to s \ell^+\ell^-$ with $\ell=e,\mu$. While Leptoquarks appear in theories unifying quarks and leptons, the corresponding unification scale $M_{QLU}$ is typically many orders of magnitude above this mass range. We study the case that the mass gap between the electroweak scale and $M_{QLU}$ is only populated by scalar Leptoquarks and SM particles, restricting ourselves to scenarios addressing the mentioned flavour anomalies, and determine the renormalisation-group evolution of Leptoquark couplings to fermions below $M_{QLU}$. In the most general case, we consider three SU(2) triplet Leptoquarks $S_3^\ell$, $\ell=e,\mu,\tau$, which couple quark doublets to the lepton doublet $(\nu_\ell,\ell^-)$ to address the $b\to s \ell^+\ell^-$ anomalies. In this case, we find a scenario in which the Leptoquark couplings to electrons and muons are driven to the same infrared fixed point, so that lepton flavour universality emerges dynamically. However, the corresponding fixed point for the couplings to taus is necessarily opposite in sign, leading to a unique signature in $b \to s\tau^+\tau^-$. For $b\to c\tau \bar\nu$ we complement these with either an SU(2) singlet $S_1^\tau$ or doublet $R_2^\tau$ and study further the cases that also these Leptoquarks come in three replicas. The fixed point solutions for the $S_3^\ell$ couplings explain the $b\to s \ell^+\ell^-$ data for $S_3^{e,\mu}$ masses around 10 TeV. $b\to c\tau \bar\nu$ data can only be fully explained by couplings exceeding their fixed-point values and evolving into Landau poles at high energies, so that one can place an upper bound on $M_{QLU}$ between $10^{8}$ and $10^{11}$ GeV., Comment: 30 pages, 4 figures. References added, matching journal version
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- 2023
69. FABRIC: Personalizing Diffusion Models with Iterative Feedback
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von Rütte, Dimitri, Fedele, Elisabetta, Thomm, Jonathan, and Wolf, Lukas
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Computer Science - Computer Vision and Pattern Recognition ,I.2.10 - Abstract
In an era where visual content generation is increasingly driven by machine learning, the integration of human feedback into generative models presents significant opportunities for enhancing user experience and output quality. This study explores strategies for incorporating iterative human feedback into the generative process of diffusion-based text-to-image models. We propose FABRIC, a training-free approach applicable to a wide range of popular diffusion models, which exploits the self-attention layer present in the most widely used architectures to condition the diffusion process on a set of feedback images. To ensure a rigorous assessment of our approach, we introduce a comprehensive evaluation methodology, offering a robust mechanism to quantify the performance of generative visual models that integrate human feedback. We show that generation results improve over multiple rounds of iterative feedback through exhaustive analysis, implicitly optimizing arbitrary user preferences. The potential applications of these findings extend to fields such as personalized content creation and customization., Comment: 14 pages, 7 figures
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- 2023
70. Electrical detection of the flat band dispersion in van der Waals field-effect structures
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Pasquale, Gabriele, Lopriore, Edoardo, Sun, Zhe, Čerņevičs, Kristiāns, Tagarelli, Fedele, Watanabe, Kenji, Taniguchi, Takashi, Yazyev, Oleg V., and Kis, Andras
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Two-dimensional flat-band systems have recently attracted considerable interest due to the rich physics unveiled by emergent phenomena and correlated electronic states at van Hove singularities. However, the difficulties in electrically detecting the flat band position in field-effect structures are slowing down the investigation of their properties. In this work, we employ Indium Selenide (InSe) as a flat-band system due to a van Hove singularity at the valence band edge in a few-layer form of the material without the requirement of a twist angle. We investigate tunneling photocurrents in gated few-layer InSe structures and relate them to ambipolar transport and photoluminescence measurements. We observe an appearance of a sharp change in tunneling mechanisms due to the presence of the van Hove singularity at the flat band. We further corroborate our findings by studying tunneling currents as a reliable probe for the flat-band position up to room temperature. Our results create an alternative approach to studying flat-band systems in heterostructures of 2D materials.
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- 2023
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71. OpenMask3D: Open-Vocabulary 3D Instance Segmentation
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Takmaz, Ayça, Fedele, Elisabetta, Sumner, Robert W., Pollefeys, Marc, Tombari, Federico, and Engelmann, Francis
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Computer Science - Computer Vision and Pattern Recognition - Abstract
We introduce the task of open-vocabulary 3D instance segmentation. Current approaches for 3D instance segmentation can typically only recognize object categories from a pre-defined closed set of classes that are annotated in the training datasets. This results in important limitations for real-world applications where one might need to perform tasks guided by novel, open-vocabulary queries related to a wide variety of objects. Recently, open-vocabulary 3D scene understanding methods have emerged to address this problem by learning queryable features for each point in the scene. While such a representation can be directly employed to perform semantic segmentation, existing methods cannot separate multiple object instances. In this work, we address this limitation, and propose OpenMask3D, which is a zero-shot approach for open-vocabulary 3D instance segmentation. Guided by predicted class-agnostic 3D instance masks, our model aggregates per-mask features via multi-view fusion of CLIP-based image embeddings. Experiments and ablation studies on ScanNet200 and Replica show that OpenMask3D outperforms other open-vocabulary methods, especially on the long-tail distribution. Qualitative experiments further showcase OpenMask3D's ability to segment object properties based on free-form queries describing geometry, affordances, and materials., Comment: NeurIPS 2023. Project page: https://openmask3d.github.io/
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- 2023
72. On the Effective Mass of Mechanical Lattices with Microstructure
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Fedele, Francesco, Suryanarayana, Phanish, and Yavari, Arash
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Physics - Classical Physics ,Condensed Matter - Soft Condensed Matter - Abstract
We present a general formalism for the analysis of mechanical lattices with microstructure using the concept of effective mass. We first revisit a classical case of microstructure being modeled by a spring-interconnected mass-in-mass cell. The frequency-dependent effective mass of the cell is the sum of a static mass and of an added mass, in analogy to that of a swimmer in a fluid. The effective mass is derived using three different methods: momentum equivalence, action equivalence, and dynamic condensation. These methods are generalized to mechanical systems with arbitrary microstructure. As an application, we calculate the effective mass of a $1$D composite lattice with microstructure modeled by a chiral spring-interconnected mass-in-mass cell. A reduced (condensed) model of the full lattice is then obtained by lumping the microstructure into a single effective mass. A dynamic Bloch analysis is then performed using both the full and reduced lattice models, which give the same spectral results. In particular, the frequency bands follow from the full lattice model by solving a linear eigenvalue problem, or from the reduced lattice model by solving a smaller nonlinear eigenvalue problem. The range of frequencies of negative effective mass falls within the bandgaps of the lattice. Localized modes due to defects in the microstructure have frequencies within the bandgaps, inside the negative-mass range. Defects of the outer, or macro stiffness yield localized modes within each bandgap, but outside the negative-mass range. The proposed formalism can be applied to study the odd properties of coupled micro-macro systems, e.g., active matter.
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- 2023
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73. FAUST IX. Multi-band, multi-scale dust study of L1527 IRS. Evidence for dust properties variations within the envelope of a Class 0/I YSO
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Cacciapuoti, L., Macias, E., Maury, A. J., Chandler, C. J., Sakai, N., Tychoniec, Ł., Viti, S., Natta, A., De Simone, M., Miotello, A., Codella, C., Ceccarelli, C., Podio, L., Fedele, D., Johnstone, D., Shirley, Y., Liu, B. J., Bianchi, E., Zhang, Z. E., Pineda, J., Loinard, L., Ménard, F., Lebreuilly, U., Klessen, R. S., Hennebelle, P., Molinari, S., Testi, L., and Yamamoto, S.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Early dust grain growth in protostellar envelopes infalling on young discs has been suggested in recent studies, supporting the hypothesis that dust particles start to agglomerate already during the Class 0/I phase of young stellar objects (YSOs). If this early evolution were confirmed, it would impact the usually assumed initial conditions of planet formation, where only particles with sizes $\lesssim 0.25 \mu$m are usually considered for protostellar envelopes. We aim to determine the maximum grain size of the dust population in the envelope of the Class 0/I protostar L1527 IRS, located in the Taurus star-forming region (140 pc). We use Atacama Large millimetre/sub-millimetre Array (ALMA) and Atacama Compact Array (ACA) archival data and present new observations, in an effort to both enhance the signal-to-noise ratio of the faint extended continuum emission and properly account for the compact emission from the inner disc. Using observations performed in four wavelength bands and extending the spatial range of previous studies, we aim to place tight constraints on the spectral ($\alpha$) and dust emissivity ($\beta$) indices in the envelope of L1527 IRS. We find a rather flat $\alpha \sim$ 3.0 profile in the range 50-2000 au. Accounting for the envelope temperature profile, we derive values for the dust emissivity index, 0.9 < $\beta$ < 1.6, and reveal a tentative, positive outward gradient. This could be interpreted as a distribution of mainly ISM-like grains at 2000 au, gradually progressing to (sub-)millimetre-sized dust grains in the inner envelope, where at R=300 au, $\beta$ = 1.1 +/- 0.1. Our study supports a variation of the dust properties in the envelope of L1527 IRS. We discuss how this can be the result of in-situ grain growth, dust differential collapse from the parent core, or upward transport of disc large grains., Comment: Accepted for publication in A&A. Contains 18 pages, 21 figures, 5 tables Replacement on Nov 22 to change title number of FAUST series from "X" to "IX."
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- 2023
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74. Discriminating $B\to D^{*}\ell\nu$ form factors via polarization observables and asymmetries
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Fedele, Marco, Blanke, Monika, Crivellin, Andreas, Iguro, Syuhei, Nierste, Ulrich, Simula, Silvano, and Vittorio, Ludovico
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,High Energy Physics - Lattice - Abstract
Form factors are crucial theory input in order to extract $|V_{cb}|$ from $B \to D^{(*)}\ell\nu$ decays, to calculate the Standard Model prediction for ${\cal R}(D^{(*)})$ and to assess the impact of New Physics. In this context, the Dispersive Matrix approach, a first-principle calculation of the form factors, using no experimental data but rather only lattice QCD results as input, was recently applied to $B \to D^{(*)}\ell\nu$. It predicts (within the Standard Model) a much milder tension with the ${\cal R}(D^*)$ measurements than the other form factor approaches, while at the same time giving a value of $|V_{cb}|$ compatible with the inclusive value. However, this comes at the expense of creating tensions with differential $B\to D^*\ell\nu$ distributions (with light leptons). In this article, we explore the implications of using the Dispersive Matrix method form factors, in light of the recent Belle (II) measurements of the longitudinal polarization fraction of the $D^*$ in $B\to D^*\ell\nu$ with light leptons, $F_L^{\ell}$, and the forward-backward asymmetry, $A_{\rm FB}^{\ell}$. We find that the Dispersive Matrix approach predicts a Standard Model value of $F_L^{\ell}$ that is in significant tension with these measurements, while mild deviations in $A_{\rm FB}^{\ell}$ appear. Furthermore, $F_L^{\ell}$ is very insensitive to New Physics such that the latter cannot account for the tension between Dispersive Matrix predictions and its measurement. While this tension can be resolved by deforming the original Dispersive Matrix form factor shapes within a global fit, a tension in ${\cal R}(D^*)$ reemerges. As this tension is milder than for the other form factors, it can be explained by New Physics not only in the tau lepton channel but also in the light lepton modes., Comment: Journal version, conclusions unchanged. 16 pages, 3 figures, 1 appendix
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- 2023
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75. Prospects for $B_c^+$ and $B^+\to \tau^+ \nu_\tau$ at FCC-ee
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Fedele, Marco, Helsens, Clément, Hill, Donal, Iguro, Syuhei, Klute, Markus, and Zuo, Xunwu
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The prospects are presented for precise measurements of the branching ratios of the purely leptonic $B_c^+ \to \tau^+ \nu_\tau$ and $B^+ \to \tau^+ \nu_\tau$ decays at the Future Circular Collider (FCC). This work is focused on the hadronic $\tau^{+} \to \pi^+ \pi^+ \pi^- \bar{\nu}_\tau$ decay in both $B_c^+ \to \tau^+ \nu_\tau$ and $B^+ \to \tau^+ \nu_\tau$ processes. Events are selected with two Boosted Decision Tree algorithms to optimise the separation between the two signal processes as well as the generic hadronic $Z$ decay backgrounds. The range of the expected precision for both signals are evaluated in different scenarios of non-ideal background modelling. This paper demonstrates, for the first time, that the $B^+ \to \tau^+ \nu_\tau$ decay can be well separated from both $B_c^+ \to \tau^+ \nu_\tau$ and generic $Z\to b\bar{b}$ processes in the FCC-ee collision environment and proposes the corresponding branching ratio measurement as a novel way to determine the CKM matrix element $|V_{ub}|$. The theoretical impacts of both $B^+ \to \tau^+ \nu_\tau$ and $B_c^+ \to \tau^+ \nu_\tau$ measurements on New Physics cases are discussed for interpretations in the generic Two-Higgs-doublet model and leptoquark models., Comment: 39 pages, 19 figures, 5 tables
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- 2023
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76. Electrically tunable dipolar interactions between layer-hybridized excitons
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Erkensten, Daniel, Brem, Samuel, Perea-Causin, Raul, Hagel, Joakim, Tagarelli, Fedele, Lopriore, Edoardo, Kis, Andras, and Malic, Ermin
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Transition-metal dichalcogenide bilayers exhibit a rich exciton landscape including layer-hybridized excitons, i.e. excitons which are of partly intra- and interlayer nature. In this work, we study hybrid exciton-exciton interactions in naturally stacked WSe$_2$ homobilayers. In these materials, the exciton landscape is electrically tunable such that the low-energy states can be rendered more or less interlayer-like depending on the strength of the external electric field. Based on a microscopic and material-specific many-particle theory, we reveal two intriguing interaction regimes: a low-dipole regime at small electric fields and a high-dipole regime at larger fields, involving interactions between hybrid excitons with a substantially different intra- and interlayer composition in the two regimes. While the low-dipole regime is characterized by weak inter-excitonic interactions between intralayer-like excitons, the high-dipole regime involves mostly interlayer-like excitons which display a strong dipole-dipole repulsion and give rise to large spectral blue-shifts and a highly anomalous diffusion. Overall, our microscopic study sheds light on the remarkable electrical tunability of hybrid exciton-exciton interactions in atomically thin semiconductors and can guide future experimental studies in this growing field of research., Comment: 8+8 pages, 4+2 figures
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- 2023
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77. Design and Implementation of a Sickle Cell Disease Electronic Registry in Resource Limited Setting in Nigeria—A Pilot Study
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Muhammad Aminu Idris, Lucia Ruggieri, Hafsat Rufai Ahmad, Abdulaziz Hassan, Ismaila Nda Ibrahim, Faruk Jamil Adullahi, Sani Awwalu, Usman Nasiru, Fedele Bonifazi, and Baba P. D. Inusa
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sickle cell disease ,electronic registry ,database ,Medicine - Abstract
Background: Sickle cell disease (SCD) is an autosomal recessive haemoglobin disorder, affecting about 7.74 million individuals worldwide, but it is more prevalent among Africans and Asians. SCD is characterised by many complications, and it is a major health issue in Nigeria, the country with the largest burden of the disease globally. This work aims to present the design and implementation of electronic registries (ER) for SCD in a tertiary hospital in Nigeria. Methods: Registry design was initiated during a staff exchange programme within the ARISE initiative (EU grant agreement no. 824021). Ethical approval was obtained, and paper records were retrieved and transferred into one adult and one paediatric database, developed with Microsoft Access. Results: Data from 2659 SCD patients were entered in the ERs, including 698 (26.3%) adults and 1961 (73.7%) children. There were 287 (41%) male adults, 404 (58%) female and 7 (1%) patients whose gender was missing. There were 1041 (53.1%) male children, 906 (46.2%) female and 14 (0.7%) whose gender was missing. Information on phenotype was available for 2385 subjects, and most of them (2082, 87.3%) were SS. The most prevalent SCD-related complication was painful events (26.6% in adults and 68.7% in children, considering valid cases). Conclusions: About 60% of SCD patients in the centre were included in the ERs providing useful, hands-on recommendations for future ER design in SCD. These ERs might be an appropriate tool for collecting and analysing SCD patients’ data.
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- 2024
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78. The Future of Public Sector Accounting Education: A Structured Literature Review
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Rubens Pauluzzo, Paolo Fedele, Elisabetta Pericolo, and Irina Dokalskaya
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Public sector accounting education (PSAE) has recently attracted increasing attention from both scholars and practitioners. Nonetheless, there is still an education/practice gap that undermines public servants' ability to face the complexity of the current working environment. This paper reviews and critiques the PSAE literature, identifies the main practical issues affecting the field, and outlines how education providers can improve formal and non-formal curricula and training. Results reveal that the exploratory nature of a large part of the PSAE research and the lack of a practical perspective able to bridge the gap between PSAE and the requirements in practice of the current public sector context demonstrate the pressing need to develop the topic and how it is investigated. The present review is one of the first attempts to investigate PSAE with a focus on the practical approaches that could be used for the development of graduates and public servants' accounting competencies.
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- 2024
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79. A simple extension of Timoshenko beam model to describe dissipation in cementitious elements
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Aretusi, Giuliano, Cardillo, Christian, Salvatori, Antonello, Bednarczyk, Ewa, and Fedele, Roberto
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- 2024
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80. Bicrossproduct vs. twist quantum symmetries in noncommutative geometries: the case of $\varrho$-Minkowski
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Fabiano, Giuseppe, Gubitosi, Giulia, Lizzi, Fedele, Scala, Luca, and Vitale, Patrizia
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High Energy Physics - Theory ,Mathematics - Quantum Algebra - Abstract
We discuss the quantum Poincar\'e symmetries of the $\varrho$-Minkowski spacetime, a space characterised by an angular form of noncommutativity. We show that it is possible to give them both a bicrossproduct and a Drinfel'd twist structure. We also obtain a new noncommutative $\star$-product, which is cyclic with respect to the standard integral measure., Comment: 38 pages, including appendices. Minor corrections. Two references added
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- 2023
81. lifex-cfd: an open-source computational fluid dynamics solver for cardiovascular applications
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Africa, Pasquale Claudio, Fumagalli, Ivan, Bucelli, Michele, Zingaro, Alberto, Fedele, Marco, Dede', Luca, and Quarteroni, Alfio
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Physics - Fluid Dynamics ,Computer Science - Mathematical Software ,Mathematics - Numerical Analysis - Abstract
Computational fluid dynamics (CFD) is an important tool for the simulation of the cardiovascular function and dysfunction. Due to the complexity of the anatomy, the transitional regime of blood flow in the heart, and the strong mutual influence between the flow and the physical processes involved in the heart function, the development of accurate and efficient CFD solvers for cardiovascular flows is still a challenging task. In this paper we present lifex-cfd, an open-source CFD solver for cardiovascular simulations based on the lifex finite element library, written in modern C++ and exploiting distributed memory parallelism. We model blood flow in both physiological and pathological conditions via the incompressible Navier-Stokes equations, accounting for moving cardiac valves, moving domains, and transition-to-turbulence regimes. In this paper, we provide an overview of the underlying mathematical formulation, numerical discretization, implementation details and examples on how to use lifex-cfd. We verify the code through rigorous convergence analyses, and we show its almost ideal parallel speedup. We demonstrate the accuracy and reliability of the numerical methods implemented through a series of idealized and patient-specific vascular and cardiac simulations, in different physiological flow regimes. The lifex-cfd source code is available under the LGPLv3 license, to ensure its accessibility and transparency to the scientific community, and to facilitate collaboration and further developments.
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- 2023
82. FAUST VIII. The protostellar disk of VLA 1623-2417 W and its streamers imaged by ALMA
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Mercimek, S., Podio, L., Codella, C., Chahine, L., López-Sepulcre, A., Ohashi, S., Loinard, L., Johnstone, D., Menard, F., Cuello, N., Caselli, P., Zamponi, J., Aikawa, Y., Bianchi, E., Busquet, G., Pineda, J. E., Bouvier, M., De Simone, M., Zhang, Y., Sakai, N., Chandler, C. J., Ceccarelli, C., Alves, F., Durán, A., Fedele, D., Murillo, N., Jiménez-Serra, I., and Yamamoto, S.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
More than 50% of solar-mass stars form in multiple systems. It is therefore crucial to investigate how multiplicity affects the star and planet formation processes at the protostellar stage. We report continuum and C$^{18}$O (2-1) observations of the VLA 1623-2417 protostellar system at 50 au angular resolution as part of the ALMA Large Program FAUST. The 1.3 mm continuum probes the disks of VLA 1623A, B, and W, and the circumbinary disk of the A1+A2 binary. The C$^{18}$O emission reveals, for the first time, the gas in the disk-envelope of VLA 1623W. We estimate the dynamical mass of VLA 1623W, $M_{\rm dyn}=0.45\pm0.08$ M$_{\odot}$, and the mass of its disk, $M_{\rm disk}\sim6\times10^{-3}$ M$_{\odot}$. C$^{18}$O also reveals streamers that extend up to 1000 au, spatially and kinematically connecting the envelope and outflow cavities of the A1+A2+B system with the disk of VLA 1623W. The presence of the streamers, as well as the spatial ($\sim$1300 au) and velocity ($\sim$2.2 km/s) offset of VLA 1623W suggest that either sources W and A+B formed in different cores, interacting between them, or that source W has been ejected from the VLA 1623 multiple system during its formation. In the latter case, the streamers may funnel material from the envelope and cavities of VLA 1623AB onto VLA 1623W, thus concurring to set its final mass and chemical content., Comment: 10 pages, 5 figures, accepted by MNRAS
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- 2023
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83. Empirical Determination of the Lithium 6707.856 {\AA} Wavelength in Young Stars
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Campbell-White, Justyn, Manara, Carlo F., Sicilia-Aguilar, Aurora, Frasca, Antonio, Nielsen, Louise D., Schneider, P. Christian, Nisini, Brunella, Bayo, Amelia, Ercolano, Barbara, Ábrahám, Péter, Claes, Rik, Fang, Min, Fedele, Davide, Gameiro, Jorge Filipe, Gangi, Manuele, Kóspál, Ágnes, Maucó, Karina, Petr-Gotzens, Monika G., Rigliaco, Elisabetta, Robinson, Connor, Siwak, Michal, Tychoniec, Lukasz, and Venuti, Laura
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Absorption features in stellar atmospheres are often used to calibrate photocentric velocities for kinematic analysis of further spectral lines. The Li feature at $\sim$ 6708 {\AA} is commonly used, especially in the case of young stellar objects for which it is one of the strongest absorption lines. However, this is a complex line comprising two isotope fine-structure doublets. We empirically measure the wavelength of this Li feature in a sample of young stars from the PENELLOPE/VLT programme (using X-Shooter, UVES and ESPRESSO data) as well as HARPS data. For 51 targets, we fit 314 individual spectra using the STAR-MELT package, resulting in 241 accurately fitted Li features, given the automated goodness-of-fit threshold. We find the mean air wavelength to be 6707.856 {\AA}, with a standard error of 0.002 {\AA} (0.09 km/s) and a weighted standard deviation of 0.026 {\AA} (1.16 km/s). The observed spread in measured positions spans 0.145 {\AA}, or 6.5 km/s, which is up to a factor of six higher than typically reported velocity errors for high-resolution studies. We also find a correlation between the effective temperature of the star and the wavelength of the central absorption. We discuss how exclusively using this Li feature as a reference for photocentric velocity in young stars could potentially be introducing a systematic positive offset in wavelength to measurements of further spectral lines. If outflow tracing forbidden lines, such as [O i] 6300 {\AA}, are actually more blueshifted than previously thought, this then favours a disk wind as the origin for such emission in young stars., Comment: Accepted for publication in A&A
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- 2023
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84. On the impact of short laser pulses on cold diluted plasmas
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Fiore, Gaetano, De Nicola, Sergio, Akhter, Tahmina, Fedele, Renato, and Jovanović, Dušan
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Physics - Plasma Physics ,Mathematical Physics ,Physics - Accelerator Physics ,35Q60, 76Wxx, 34Cxx, 82D10 - Abstract
We analytically study the impact of a short laser pulse onto an inhomogeneous cold diluted plasma at rest, in particular: the duration of the hydrodynamic regime; the formation and the features of plasma waves (PWs); their wave-breakings (WBs); the motion of test electrons injected in the PWs. If the pulse is a plane wave travelling in the $z$-direction, and the initial plasma density (IPD) depends only on $z$, then suitable matched bounds on the maximum and relative variations of the IPD, as well as the intensity and duration of the pulse, ensure a strictly hydrodynamic evolution of the electron fluid during its whole interaction with the pulse, while ions can be regarded as immobile. This evolution is ruled by a family (parametrized by $Z\ge 0$) of decoupled systems of non-autonomous Hamilton equations with 1 degree of freedom, which determine how electrons initially located in the layer $Z\le z
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- 2023
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85. Electrical control of hybrid exciton transport in a van der Waals heterostructure
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Tagarelli, Fedele, Lopriore, Edoardo, Erkensten, Daniel, Perea-Causín, Raül, Brem, Samuel, Hagel, Joakim, Sun, Zhe, Pasquale, Gabriele, Watanabe, Kenji, Taniguchi, Takashi, Malic, Ermin, and Kis, Andras
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science ,Condensed Matter - Quantum Gases - Abstract
Interactions between out-of-plane dipoles in bosonic gases enable the long-range propagation of excitons. The lack of direct control over collective dipolar properties has hitherto limited the degrees of tunability and the microscopic understanding of exciton transport. In this work, we modulate the layer hybridization and interplay between many-body interactions of excitons in a van der Waals heterostructure with an applied vertical electric field. By performing spatiotemporally resolved measurements supported by microscopic theory, we uncover the dipole-dependent properties and transport of excitons with different degrees of hybridization. Moreover, we find constant emission quantum yields of the transporting species as a function of excitation power with dominating radiative decay mechanisms over nonradiative ones, a fundamental requirement for efficient excitonic devices. Our findings provide a complete picture of the many-body effects in the transport of dilute exciton gases and have crucial implications for the study of emerging states of matter, such as Bose-Einstein condensation, as well as for optoelectronic applications based on exciton propagation.
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- 2023
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86. Kinematics signature of a giant planet in the disk of AS 209
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Fedele, D., Bollati, F., and Lodato, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
[abridged] ALMA observations of dust in protoplanetary disks are revealing the existence of sub-structures such as rings, gaps and cavities. Such morphology are expected to be the outcome of dynamical interaction between the disk and planets. However, other mechanisms are able to produce similar dust sub-structures. A solution is to look at the perturbation induced by the planet to the gas surface density and/or to the kinematics. In the case of the disk around AS 209, a prominent gap has been reported in the surface density of CO at $r \sim 100\,$au. Recently, Bae et al. (2022) detected a localized velocity perturbation in the $^{12}$CO $J=2-1$ emission along with a clump in $^{13}$CO $J=2-1$ at nearly 200 au, interpreted as a gaseous circumplanetary disk. We report a new analysis of ALMA archival observations of $^{12}$CO and $^{13}$CO J=2-1. A clear kinematics perturbation (kink) is detected in multiple channels and over a wide azimuth range in both dataset. We compared the observed perturbation with a semi-analytic model of velocity perturbations due to planet-disk interaction. The observed kink is not consistent with a planet at 200\,au as this would require a low gas disk scale height ($< 0.05$) in contradiction with previous estimate ($h/r \sim 0.118$ at $r = 100$ au). When we fix the disk scale height to 0.118 (at $r = 100$ au) we find instead that a planet of 3-5 M$_{\rm Jup}$ at 100 au induces a kinematics perturbation similar to the observed one. Thus, we conclude that a giant protoplanet orbiting at $r \sim 100\,$au is responsible of the large scale kink as well as of the perturbed dust and gas surface density previously detected. The position angle of the planet is constrained to be between 60$^{\circ}$-100$^{\circ}$. Future observations with high contrast imaging technique in the near- and mid- infrared are needed to confirm the presence and position of such a planet., Comment: Accepted by A&A
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- 2023
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87. Geometric Phases of Nonlinear Elastic $N$-Rotors via Cartan's Moving Frames
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Fedele, Francesco and Yavari, Arash
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Physics - Classical Physics ,Mathematical Physics - Abstract
We study the geometric phases of nonlinear elastic $N$-rotors with continuous rotational symmetry. In the Hamiltonian framework, the geometric structure of the phase space is a principal fiber bundle, i.e., a base, or shape manifold~$\mathcal{B}$, and fibers $\mathcal{F}$ along the symmetry direction attached to it. The symplectic structure of the Hamiltonian dynamics determines the connection and curvature forms of the shape manifold. Using Cartan's structural equations with zero torsion we find an intrinsic (pseudo) Riemannian metric for the shape manifold. One has the freedom to define the rotation sign of the total angular momentum of the elastic rotors as either positive or negative, e.g., counterclockwise or clockwise, respectively, or viceversa. This endows the base manifold~$\mathcal{B}$ with two distinct metrics both compatible with the geometric phase. In particular, the metric is pseudo-Riemannian if $\mathsf{A}<0$, and the shape manifold is a $2$D~Robertson-Walker spacetime with positive curvature. For $\mathsf{A}>0$, the shape manifold is the hyperbolic plane $\mathbb{H}^2$ with negative curvature. We then generalize our results to free elastic $N$-rotors. We show that the associated shape manifold~$\mathcal{B}$ is reducible to the product manifold of $(N-1)$ hyperbolic planes $\mathbb{H}^2$~($\mathsf{A}>0$), or $2$D~Robertson-Walker spacetimes~($\mathsf{A}<0$) depending on the convection used to define the rotation sign of the total angular momentum. We then consider elastic $N$-rotors subject to time-dependent self-equilibrated moments. The $N$-dimensional shape manifold of the extended autonomous system has a structure similar to that of the $(N-1)$-dimensional shape manifold of free elastic rotors. The Riemannian structure of the shape manifold provides an intrinsic measure of the closeness of one shape to another in terms of curvature, or induced geometric phase.
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- 2023
88. Eccentric strengthening vs. conventional therapy in sub-acute stroke survivors: a randomized controlled trial
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Kalthoum Belghith, Mustapha Zidi, Lhéo Vincent, Jean-Michel Fedele, Rayan Bou-Serhal, and Wael Maktouf
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muscle strength ,stiffness ,ankle joint ,eccentric training ,stroke ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Spastic paresis, a frequent consequence of stroke, is characterized by both neurological and muscular alterations, leading to decreased muscle strength, increased passive muscle stiffness, and subsequently, diminished functional capacity. Although conventional rehabilitation programs are effective in enhancing muscle strength, they often fail to yield clinically significant improvements in functional capacities. Eccentric Training (ET) has shown promise in addressing the shortened muscle fascicle lengths and joint contractures commonly observed in stroke survivors. Despite the prevalence of contractures and rigidity in this population, the effects of ET on the structural and mechanical properties of muscles remain underexplored. This study aims to investigate the impact of ET on gait speed in sub-acute stroke patients compared to conventional therapy. Additionally, we aim to explore the effects of ET on the mechanical properties, structural characteristics, and neuromuscular parameters of the plantar flexors. A randomized controlled trial will be conducted, adhering to CONSORT guidelines, with participants assigned to either a Conventional Therapy Group or an Eccentric Training Group. Assessments will be conducted at baseline, and after ET intervention, encompassing clinical, biomechanical, and functional evaluations. This study seeks to provide empirical evidence on the efficacy of ET in improving motor outcomes in sub-acute stroke patients, thereby informing more effective rehabilitation strategies.
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- 2025
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89. Complete Lifestyle Medicine Intervention Program–Ontario: Implementation Protocol for a Rural Study
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Kush Patel, Lisa Allen, Karine Boucher, Michelle Fedele, Debbie Fong, Sangeeta Kumar, Deanna Lavigne, Elisa Marin-Couture, Magdalena Partyka-Sitnik, Nicole Rietze, Jenna Smith-Turchyn, Mylene Juneau, and Caroline Rhéaume
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Medicine ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
BackgroundSedentary lifestyles, poor nutritional choices, inadequate sleep, risky substance use, limited social connections, and high stress contribute to the growing prevalence of chronic diseases. Lifestyle medicine, emphasizing therapeutic lifestyle changes for prevention and treatment, has demonstrated effectiveness but remains underutilized in clinical settings. The Complete Lifestyle Medicine Intervention Program–Ontario (CLIP-ON) was developed to educate the rural population of Northern Ontario in lifestyle medicine to improve health outcomes and engagement. ObjectiveThis study evaluates the implementation and effectiveness of the CLIP-ON program for patients with chronic diseases in the Parry Sound area, focusing on lifestyle behaviors, health outcomes, enrollment, retention rates, and interdisciplinary team engagement. MethodsThis observational cohort study guided by the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance) includes pre- and postintervention assessments from participants and health care providers. A hybrid type II mixed methods design evaluates the intervention’s effectiveness and implementation process in real-world settings through quantitative and qualitative data collection. CLIP-ON is tailored to the residents of the Parry Sound catchment area in Northern Ontario. Participants (≥18 years old) with chronic conditions such as prediabetes, type II diabetes, systemic hypertension, cardiovascular vascular disease, dyslipidemia, or high BMI (≥25) will be recruited through self-referral or provider referral. Approximately 10 participants per cohort will be enrolled in the CLIP-ON program, consisting of 22 weeks of weekly group sessions and monthly individual consultations with physicians, health coaches, kinesiologists, and registered dieticians either in person or through a web-based platform. CLIP-ON will cover the 6 pillars of lifestyle medicine through 14 group sessions followed by an 8-week supervised exercise program. Anthropometric and cardiometabolic variables will be measured before and after the program. Participants will be surveyed on lifestyle habits, wellness, perceived barriers, and program satisfaction at 3 and 6 months. Focus groups and dropout interviews with participants (n=10 per cohort) and providers (n=6 per cohort) will guide program adaptations. Quantitative and qualitative data collected at baseline and follow-up will assess the program’s implementation and identify barriers and opportunities for improvement. ResultsThis study was approved by the Laurentian University Research Ethics Board (6021397) on July 6, 2023. The first cohort was enrolled in late 2023 and is still under evaluation. The second cohort began in mid-2024, and data collection is currently underway. A mixed methods analysis will be used at enrollment, program completion (22 weeks), and follow-up (6 months after program completion). Focus groups assessing the program’s effectiveness and implementation will take place after the 22-week intervention. Data will be analyzed in early 2025. ConclusionsThis protocol provides insights into the implementation of this lifestyle medicine program and its impact on participants’ health. The findings will guide future advancements and establish a scalable model for other communities. Trial RegistrationClinicalTrials.gov NCT06192251; https://clinicaltrials.gov/study/NCT06192251 International Registered Report Identifier (IRRID)DERR1-10.2196/59179
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- 2024
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90. Fanoli, F. (2022). Arene di Lotta. Corpi, mascolinità e invisibile nel làmb a Dakar. Meltemi: Milano
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Valentina Fedele
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Sports ,GV557-1198.995 ,Social Sciences ,Sociology (General) ,HM401-1281 - Published
- 2024
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91. Formación metropolitana sin planificación
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Javier Fedele, Cecilia Galimberti, and Cintia Barenboim
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área metropolitana ,mercado inmobiliario ,expansión urbana ,planeamiento ,Architecture ,NA1-9428 ,Urban groups. The city. Urban sociology ,HT101-395 - Abstract
Las áreas metropolitanas son formaciones territoriales que surgen de la intensificación e interrelación de actividades en un espacio expandido al de la ciudad compacta primaria. Hay un momento en las fases de transformación que este proceso de formación metropolitana se acelera, especialmente cuando las infraestructuras de conexión territorial trascienden su rol de movilidad, para constituirse en vectores del crecimiento urbano y potenciar modalidades de ocupación del suelo. Ese quiebre hacia una nueva escala territorial es lo que el artículo aborda, estudiando el sector oeste del Área Metropolitana de Rosario. Se parte de un análisis histórico del proceso de urbanización, identificando los principales hechos catalizadores de los cambios de ocupación y uso de suelo; para luego focalizarse en las últimas dos décadas, indagando especialmente en el rol central del mercado residencial como impulsor de nuevas urbanizaciones, frente a instrumentos de ordenamiento desactualizados o que actúan como simples posibilitadores. Se reconocen desequilibrios producto de amplios sectores de crecimiento rápido y discontinuo, apoyados en estas trazas territoriales radiales, sin infraestructuras suficientes y en completa dependencia en empleo y servicios de la ciudad primaria. Una formación metropolitana sin planificación, dado que carece de las sub-centralidades y bienes urbanos propios de las áreas en estado avanzado.
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- 2024
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92. Introduction
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Dante Fedele and Wouter Druwé
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Social Sciences - Published
- 2024
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93. The impact of vaccination status on post-acute sequelae in hospitalized COVID-19 survivors using a multi-disciplinary approach: An observational single center study
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Lucia Ilaria Birtolo, Gianluca Di Pietro, Antonella Ciuffreda, Riccardo Improta, Sara Monosilio, Silvia Prosperi, Sara Cimino, Nicola Galea, Paolo Severino, Gioacchino Galardo, Maria Chiara Colaiacomo, Patrizia Pasculli, Angelo Petroianni, Paolo Palange, Claudio Maria Mastroianni, Laura de Vito, Carlo Catalano, Francesco Pugliese, Maria Rosa Ciardi, Paola Celli, Roberto Badagliacca, Francesco Fedele, Carmine Dario Vizza, Viviana Maestrini, Massimo Mancone, Agnes Gianluca, Albante Alida, Alfarano Maria, Araimo Morselli Fabio, Auricchio Daniela, Barletta Giovanna, Bilotta Federico, Brisciani Matteo, Bruno Katia, Bucarelli Maria Clelia, Cappannoli Alessandro, Ceccarelli Giancarlo, Celli Paola, Consolo Stella, Consoli Giulia, Croce Claudia, Crocitti Beatrice, D'Antoni Letizia, De Lazzaro Francesco, De Lauri Daniela, De Persis Francesca, De Rose Maria, Del Bianco Andrea, Di Bella Valerio, Di Sano Laura, Di Santo Carmela, Filomena Domenico, Giannetti Lorena, Giordano Giovanni, Ianni Stefano, Imperiale Carmela, Magnanimi Eugenia, Manganelli Chiara, Maldarelli Federica, Manzi Giovanna, Marcon Serena, Mariani Marco Valerio, Martelli Sabina, Messina Teresa, Neccia Matteo, Novelli Martina, Papa Silvia, Pasqualitto Fabiola, Pattelli Elisa, Pecorari Filippo, Perrella Serena, Passarelli Ilaria, Piazzolla Mario, Piro Agostino, Portieri Monica, Ratini Fabiola, Ricci Claudia, Romano Hilde, Sabani Anna, Santopietro Pietro, Tanzilli Alessandra, Tellan Guglielmo, Titi Luca, Tocci Marco, Tordiglione Paolo, Tosi Antonella, Trigilia Fausto, Verduci Noemi, and Vaccaro Paola
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Long-COVID19 ,mRNA vaccines ,Hospitalized ,Survivors ,Sequalae ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: COVID-19 vaccines reduced mortality, hospitalizations and ICUs admissions. Conversely, the impact of vaccination on Long COVID-19 syndrome is still unclear. This study compared the prevalence of post-acute sequelae at short and long-term follow-up among hospitalized unvaccinated and vaccinated COVID-19 survivors through a multidisciplinary approach. Methods: After 2 months from discharge, unvaccinated and vaccinated COVID-19 survivors underwent a follow-up visit at a dedicated “post-COVID-19 Outpatient Clinic”. The follow-up visit included a cardiovascular evaluation, blood tests, chest computed tomography, 6-min walking test (6MWT), spirometry. A one-year telephone follow-up was performed to assess re-hospitalizations, death and long-lasting symptoms. An additional 1:1 case-control matching analysis adjusted for baseline characteristics was performed. Results: Between June 2020 and June 2022, a total of 458 unvaccinated and vaccinated patients (229 per group) underwent the follow-up visit. Vaccinated patients had lower rates of ICU admissions (1.7 % vs 9.6 %, p=
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- 2024
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94. Alle origini della computer art
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Fedele Di Nunno
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Sociology (General) ,HM401-1281 - Abstract
Gli studi e le sperimentazioni sugli algoritmi applicati all’arte condotti da François e Véra Molnar non sono stati adeguatamente sistematizzati e compresi dalla critica. In particolare, il lavoro teorico di François appare marginale quando sembrerebbe, invece, essere stato decisivo nella creazione delle opere d’arte di Véra. Anzi, François e Véra si influenzavano reciprocamente: teoria e pratica artistica, algoritmi e opere d’arte in un continuo ciclo di ispirazione e creazione. L’articolo espone una prima parte del lavoro di ricerca condotto sui due artisti che verrà indagato ed esplorato più a fondo, approfondendo soprattutto il lavoro teorico di François Molnar, per evidenziare come il loro contributo sia stato pioneristico e decisivo per lo sviluppo della computer art.
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- 2024
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95. The microbiome analysis of ripen grape berries supports the complex etiology of sour rot
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Chiara Brischetto, Vittorio Rossi, and Giorgia Fedele
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Vitis vinifera ,minor grape rots ,bunch microflora ,high-throughput sequencing ,acetic acid bacteria ,Enterobacteriaceae ,Microbiology ,QR1-502 - Abstract
Sour rot (SR) is a grapevine disease complex that is not completely understood in its etiology and epidemiology. Recently, SR has received special attention due to its increasing economic importance due to crop losses and reduced wine quality. In this study, the fungal and bacterial microbiota of healthy (i.e., without rot symptoms) and rotten (i.e., exhibiting visual and olfactory SR symptoms) ripe bunches were characterized across 47 epidemics (39 vineyards in six Italian grape-growing areas) over three years. The 16S rRNA gene, ITS high-throughput amplicon sequencing, and quantitative PCR were used to assess the relative abundance and dynamic changes of microorganisms associated with SR. The estimators of genera richness of fungal communities within samples indicated a significantly different diversity between healthy and rotten bunches. For bacterial communities, the healthy and rotten bunches significantly differed in the total number of species, but not in abundance distribution across species. The bunch status (i.e., healthy and rotten) was a significant source of diversity (p
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- 2024
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96. Environment and healthcare: 'Why would you do this to us?': Northern territory nurses and midwives rally against middle arm industrial precinct
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Fedele, Robert
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- 2024
97. Constraints on Lepton Universality Violation from Rare $B$ Decays
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Ciuchini, Marco, Fedele, Marco, Franco, Enrico, Paul, Ayan, Silvestrini, Luca, and Valli, Mauro
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
The LHCb collaboration has very recently released a new study of $B^+ \to K^{+} \ell^+ \ell^-$ and $B \to K^{*0} \ell^+ \ell^-$ ($\ell = e,\mu$) decays, testing lepton universality with unprecedented accuracy using the whole Run 1 and 2 dataset. In addition, the CMS collaboration has recently reported an improved analysis of the branching ratios $B_{(d,s)}\to\mu^+\mu^-$. While these measurements offer, per se, a powerful probe of New Physics, global analyses of $b \to s \ell^+ \ell^-$ transitions also rely on the assumptions about nonperturbative contributions to the decay matrix elements. In this work, we perform a global Bayesian analysis of New Physics in (semi)leptonic rare $B$ decays, paying attention to the role of charming penguins which are difficult to evaluate from first principles. We find data to be consistent with the Standard Model once rescattering from intermediate hadronic states is included. Consequently, we derive stringent bounds on lepton universality violation in $|\Delta B | = | \Delta S| = 1$ (semi)leptonic processes., Comment: 10 pages, 7 figures, 2 tables. Appendix on treatments of hadronic contributions added, version to appear on journal. In loving memory of Enrico Franco, Scientist, Mentor and Friend
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- 2022
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98. Design and Structure Dependent Priors for Scale Parameters in Latent Gaussian Models
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Gardini, Aldo, Greco, Fedele, and Trivisano, Carlo
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Statistics - Methodology ,Mathematics - Statistics Theory - Abstract
Many common correlation structures assumed for data can be described through latent Gaussian models. When Bayesian inference is carried out, it is required to set the prior distribution for scale parameters that rules the model components, possibly allowing to incorporate prior information. This task is particularly delicate and many contributions in the literature are devoted to investigating such aspects. We focus on the fact that the scale parameter controls the prior variability of the model component in a complex way since its dispersion is also affected by the correlation structure and the design. To overcome this issue that might confound the prior elicitation step, we propose to let the user specify the marginal prior of a measure of dispersion of the model component, integrating out the scale parameter, the structure and the design. Then, we analytically derive the implied prior for the scale parameter. Results from a simulation study, aimed at showing the behavior of the estimators sampling properties under the proposed prior elicitation strategy, are discussed. Lastly, some real data applications are explored to investigate prior sensitivity and allocation of explained variance among model components.
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- 2022
99. Impact of $\Lambda_b\to \Lambda_c\tau\nu$ measurement on New Physics in $b\to c \, l \nu$ transitions
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Fedele, Marco, Blanke, Monika, Crivellin, Andreas, Iguro, Syuhei, Kitahara, Teppei, Nierste, Ulrich, and Watanabe, Ryoutaro
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
Measurements of the branching ratios of $B \to D^{(*)}\tau\bar\nu/B \to D^{(*)}\ell\bar\nu$ and $B_c\to J/\psi\, \tau\bar\nu/B_c\to J/\psi\, \ell\bar\nu$ by the BaBar, Belle and LHCb collaborations consistently point towards an abundance of taus compared to channels with light leptons. However, the ratio $\Lambda_b \to\Lambda_c \tau\bar\nu/\Lambda_b \to\Lambda_c \ell\bar\nu$ shows a relative deficit in taus. In this paper, we critically address whether data still points towards a coherent pattern of deviations, in particular in light of the sum rule relating these decays in a model-independent way. We find that no common new physics explanation of all ratios is possible (within $2\sigma$ or $1.5\sigma$, depending on the ${\cal R}(\Lambda_c)$ normalization to light lepton channels). While this inconsistency could be a statistical fluctuation, further measurements are required in order to converge to a coherent pattern of experimental results., Comment: 12 pages, 3 tables. Minor corrections, conclusions unchanged, matches journal version
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- 2022
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100. Stability of long-sustained oscillations induced by electron tunneling
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Tabanera-Bravo, Jorge, Vigneau, Florian, Monsel, Juliette, Aggarwal, Kushagra, Bresque, Léa, Fedele, Federico, Cerisola, Federico, Briggs, G. A. D., Anders, Janet, Aufèves, Alexia, Parrondo, Juan M. R., and Ares, Natalia
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Self-oscillations are the result of an efficient mechanism generating periodic motion from a constant power source. In quantum devices, these oscillations may arise due to the interaction between single electron dynamics and mechanical motion. We show that, due to the complexity of this mechanism, these self-oscillations may irrupt, vanish, or exhibit a bistable behaviour causing hysteresis cycles. We observe these hysteresis cycles and characterize the stability of different regimes in both single and double quantum dot configurations. In particular cases, we find these oscillations stable for over 20 seconds, many orders of magnitude above electronic and mechanical characteristic timescales, revealing the robustness of the mechanism at play., Comment: Revised version: 13 pages, 12 figures, includes the complete paper and the Supplemental Material
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- 2022
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