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216 results on '"Farnsworth, Christopher W"'

51. Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein

Author

Wu, Chao, primary, Qavi, Abraham J., additional, Moyle, Austin B., additional, Wagner, Nicole D., additional, Hachim, Asmaa, additional, Kavian, Niloufar, additional, Cole, Aidan R., additional, Sweeney-Gibbons, Joyce, additional, Rohrs, Henry W., additional, Peiris, J. S. Malik, additional, Basler, Christopher F., additional, Gross, Michael L., additional, Valkenburg, Sophie A., additional, Farnsworth, Christopher W., additional, Amarasinghe, Gaya K., additional, and Leung, Daisy W., additional

Published
2021
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54. The effect of the Covid-19 shutdown on glycemic testing and control

Author

Sharma, Anu, primary, Greene, Dina N., additional, Chambliss, Allison B., additional, Farnsworth, Christopher W., additional, French, Deborah, additional, Herman, Daniel S., additional, Kavsak, Peter A., additional, Merrill, Anna E., additional, (Margaret) Lo, Sheng-Ying, additional, Lyon, Martha E., additional, Winston-McPherson, Gabrielle, additional, Pearson, Lauren N., additional, SoRelle, Jeffrey A., additional, Waring, Avantika C., additional, and Schmidt, Robert L., additional

Published
2021
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56. Assessment of serological assays for identifying high titer convalescent plasma

Author

Farnsworth, Christopher W., primary, Case, James B., additional, Hock, Karl, additional, Chen, Rita E., additional, O'Halloran, Jane A., additional, Presti, Rachel, additional, Goss, Charles W., additional, Rauseo, Adriana M., additional, Ellebedy, Ali, additional, Theel, Elitza S., additional, Diamond, Michael S., additional, and Henderson, Jeffrey P., additional

Published
2021
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57. SARS-CoV-2 Infection Risk Factors among Maintenance Hemodialysis Patients and Health Care Personnel In Outpatient Hemodialysis Centers

Author

Gandra, Sumanth, primary, Li, Tingting, additional, Reske, Kimberly A., additional, Dang, Na Le, additional, Farnsworth, Christopher W., additional, Hock, Karl G., additional, Miller, Candace, additional, Olsen, Margaret A., additional, Kwon, Jennie H., additional, Warren, David K., additional, and Fraser, Victoria J., additional

Published
2021
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58. Clinical Performance of a Lateral Flow SARS-CoV-2 Total Antibody Assay.

Author

Cobb, Beth L, Lloyd, Matthew, Hock, Karl G, and Farnsworth, Christopher W

Subjects
MULTISYSTEM inflammatory syndrome in children, SARS-CoV-2, COVID-19 testing
Abstract

Background: Serological assays for SARS-CoV-2 are important tools for diagnosis in patients with negative RT-PCR testing, pediatric patients with multisystem inflammatory syndrome, and serosurveillance studies. However, lateral flow-based serological assays have previously demonstrated poor analytical and clinical performance, limiting their utility. Methods: We assessed the ADEXUSDx COVID-19 lateral flow assay for agreement with diagnostic RT-PCR testing using 120 specimens from RT-PCR–positive patients, 77 specimens from symptomatic RT-PCR–negative patients, and 47 specimens obtained prepandemic. Specimens collected <14 days from symptom onset in RT-PCR–positive patients were compared relative to the Abbott SARS-CoV-2 IgG assay. Results: The ADEXUSDx COVID-19 Test yielded an overall positive percent agreement (PPA) of 92.5% (95%CI 85.8 to 96.3) and negative percent agreement of 99.2% (95% CI 94.9–100.0) relative to RT-PCR and in prepandemic specimens. Relative to days from symptom onset, the PPA after 13 days was 100% (95% CI 94.2–100); from 7 to 13 days, 89.7 (95% CI 71.5–97.2); and from 0 to 7 days, 53.8 (95% CI 26.1–79.6). The overall agreement between the Abbott and ADEXUSDx assays was 80.9%. Twenty-five specimens were positive by both assays, 9 specimens were negative by both assays, and 8 specimens were positive by only the ADEXUSDx assay. Conclusions: We demonstrate high PPA and negative percent agreement of the ADEXUSDx COVID-19 assay and diagnostic testing by RT-PCR, with PPA approximately 90% by 7 days following symptom onset. The use of waived testing for antibodies to SARS-CoV-2 with high sensitivity and specificity provide a further tool for combatting the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Published
2022
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68. Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain

Author

Wu, Chao, primary, Qavi, Abraham J., additional, Hachim, Asmaa, additional, Kavian, Niloufar, additional, Cole, Aidan R., additional, Moyle, Austin B., additional, Wagner, Nicole D., additional, Sweeney-Gibbons, Joyce, additional, Rohrs, Henry W., additional, Gross, Michael L., additional, Peiris, J. S. Malik, additional, Basler, Christopher F., additional, Farnsworth, Christopher W., additional, Valkenburg, Sophie A., additional, Amarasinghe, Gaya K., additional, and Leung, Daisy W., additional

Published
2020
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82. Detecting Fentanyl Analogs in Urine Using Precursor Ion Scan Mode.

Author

Budelier, Melissa M, Franks, Caroline E, Farnsworth, Christopher W, and Roper, Stephen M

Subjects
LIQUID chromatography-mass spectrometry, FENTANYL, DAUGHTER ions, COLLISION induced dissociation
Abstract

The opioid crisis has led many providers to inquire about the capabilities of urine drug testing (UDT) to detect contemporary compounds such as fentanyl and fentanyl analogs (FAs). However, current methods for clinical UDT, including immunoassays and targeted liquid chromatography tandem mass spectrometry, are not designed to broadly screen for the variety of FAs that may be encountered. In this proof-of-principle study, we developed a precursor ion scan (PIS) method to enable semi-targeted data acquisition for structurally related FAs. Based on the knowledge that many analogs fragment to m / z  = 188 and m / z  = 105, data were acquired on all precursor ions of 250–400 Da that fragmented to these product ions. Using a tandem mass spectrometer, we analyzed 102 residual urine specimens, in which we identified fentanyl, acetylfentanyl and acrylfentanyl. In 30 contrived urine samples, the PIS was also able to identify furanylfentanyl, butyrylfentanyl, 4-fluoroisobutyrylfentanyl and despropionylfentanyl with accuracy ranging from 83% to 100%. [ABSTRACT FROM AUTHOR]

Published
2022
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83. Longitudinal analysis of risk factors associated with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among hemodialysis patients and healthcare personnel in outpatient hemodialysis centers.

Author

Gandra, Sumanth, Tingting Li, Reske, Kimberly A., Peacock, Kate, Hock, Karl G., Bommarito, Silvana, Miller, Candace, Stewart, Henry, Na Le Dang, Farnsworth, Christopher W., Olsen, Margaret A., Kwon, Jennie H., Warren, David K., and Fraser, Victoria J.

Published
2022
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85. Antibodies in healthcare personnel following severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection.

Author

Bosserman, Rachel E., Farnsworth, Christopher W., O'Neil, Caroline A., Cass, Candice, Park, Daniel, Ballman, Claire, Wallace, Meghan A., Struttmann, Emily, Stewart, Henry, Arter, Olivia, Peacock, Kate, Fraser, Victoria J., Budge, Philip J., Olsen, Margaret A., Burnham, Carey-Ann D., Babcock, Hilary M., and Kwon, Jennie H.

Published
2022
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98. Targeting the gut microbiome to treat the osteoarthritis of obesity

Author

Schott, Eric M., primary, Farnsworth, Christopher W., additional, Grier, Alex, additional, Lillis, Jacquelyn A., additional, Soniwala, Sarah, additional, Dadourian, Gregory H., additional, Bell, Richard D., additional, Doolittle, Madison L., additional, Villani, David A., additional, Awad, Hani, additional, Ketz, John P., additional, Kamal, Fadia, additional, Ackert-Bicknell, Cheryl, additional, Ashton, John M., additional, Gill, Steven R., additional, Mooney, Robert A., additional, and Zuscik, Michael J., additional

Published
2018
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