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52. Prediction of the intestinal resistome by a three-dimensional structure-based method

Author

MMB Moleculair A, Infection & Immunity, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolas, Alvarez, Anne Sophie, Maziers, Nicolas, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, Jose Luís, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, de Lastours, Victoire, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, van Schaik, Willem, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J.L., de Brevern, Alexandre G., Batto, Jean Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean P., Ehrlich, S. Dusko, MMB Moleculair A, Infection & Immunity, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolas, Alvarez, Anne Sophie, Maziers, Nicolas, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, Jose Luís, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, de Lastours, Victoire, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, van Schaik, Willem, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J.L., de Brevern, Alexandre G., Batto, Jean Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean P., and Ehrlich, S. Dusko

Published
2019

53. Prediction of the intestinal resistome by a three-dimensional structure-based method

Author

European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, European Society of Clinical Microbiology and Infectious Diseases, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolás, Álvarez, Anne-Sophie, Maziers, Nicolás, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, José Luis, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, Lastours, Victoire de, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, Schaik, Willem van, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J., Brevern, Alexandre G. de, Batto, Jean-Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean, Ehrlich, S. Dusko, European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, European Society of Clinical Microbiology and Infectious Diseases, Ruppé, Etienne, Ghozlane, Amine, Tap, Julien, Pons, Nicolás, Álvarez, Anne-Sophie, Maziers, Nicolás, Cuesta, Trinidad, Hernando-Amado, Sara, Clares, Irene, Martínez, José Luis, Coque, Teresa M., Baquero, Fernando, Lanza, Val F., Máiz, Luis, Goulenok, Tiphaine, Lastours, Victoire de, Amor, Nawal, Fantin, Bruno, Wieder, Ingrid, Andremont, Antoine, Schaik, Willem van, Rogers, Malbert, Zhang, Xinglin, Willems, Rob J., Brevern, Alexandre G. de, Batto, Jean-Michel, Blottière, Hervé M., Léonard, Pierre, Léjard, Véronique, Letur, Aline, Levenez, Florence, Weiszer, Kevin, Haimet, Florence, Doré, Joël, Kennedy, Sean, and Ehrlich, S. Dusko

Abstract

The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic elements. Yet, this assumption is poorly supported by empirical evidence due to the distant homologies between known ARDs (mostly from culturable bacteria) and ARDs from the intestinal microbiota. Consequently, an accurate census of intestinal ARDs (that is, the intestinal resistome) has not yet been fully determined. For this purpose, we developed and validated an annotation method (called pairwise comparative modelling) on the basis of a three-dimensional structure (homology comparative modelling), leading to the prediction of 6,095 ARDs in a catalogue of 3.9 million proteins from the human intestinal microbiota. We found that the majority of predicted ARDs (pdARDs) were distantly related to known ARDs (mean amino acid identity 29.8%) and found little evidence supporting their transfer between species. According to the composition of their resistome, we were able to cluster subjects from the MetaHIT cohort (n = 663) into six resistotypes that were connected to the previously described enterotypes. Finally, we found that the relative abundance of pdARDs was positively associated with gene richness, but not when subjects were exposed to antibiotics. Altogether, our results indicate that the majority of intestinal microbiota ARDs can be considered intrinsic to the dominant commensal microbiota and that these genes are rarely shared with bacterial pathogens.

Published
2019

54. Preface

Author

Zak, Oto, primary, Sande, Merle A., additional, Carbon, Claude, additional, Fantin, Bruno, additional, Kaminsky, Ronald, additional, Kern, Earl R., additional, and O'Reilly, Terence, additional

Published
1999
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57. Autochthonous case of eosinophilic meningitis caused by angiostrongylus cantonensis, France, 2016

Author

Nguyen, Yann, Rossi, Benjamin, Argy, Nicolas, Baker, Catherine, Nickel, Beatrice, Marti, Hanspeter, Zarrouk, Virginie, Houze, Sandrine, Fantin, Bruno, and Lefort, Agnes

Subjects
Travelers -- Health aspects, Meningitis -- Health aspects, Type 2 diabetes -- Health aspects, Fever -- Health aspects, Health
Abstract

Angiostrongiylus cantonensis is a rat lungworm that has long been recognized as a cause of eosinophilic meningitis in Southeast Asia, the Pacific Islands, and the Caribbean, where it is endemic [...]

Published
2017
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58. The French Gaucher’s disease registry: clinical characteristics, complications and treatment of 562 patients

Author

Stirnemann Jérôme, Vigan Marie, Hamroun Dalil, Heraoui Djazia, Rossi-Semerano Linda, Berger Marc G, Rose Christian, Camou Fabrice, de Roux-Serratrice Christine, Grosbois Bernard, Kaminsky Pierre, Robert Alain, Caillaud Catherine, Froissart Roselyne, Levade Thierry, Masseau Agathe, Mignot Cyril, Sedel Frédéric, Dobbelaere Dries, Vanier Marie T, Valayanopoulos Vassili, Fain Olivier, Fantin Bruno, de Villemeur Thierry, Mentré France, and Belmatoug Nadia

Subjects
French Gaucher’s Disease Registry, Bone events, Enzyme-replacement therapy, Medicine
Abstract

Abstract Background Clinical features, complications and treatments of Gaucher’s disease (GD), a rare autosomal–recessive disorder due to a confirmed lysosomal enzyme (glucocerebrosidase) deficiency, are described. Methods All patients with known GD, living in France, with ≥1 consultations (1980–2010), were included in the French GD registry, yielding the following 4 groups: the entire cohort, with clinical description; and its subgroups: patients with ≥1 follow-up visits, to investigate complications; recently followed (2009–2010) patients; and patients treated during 2009–2010, to examine complications before and during treatment. Data are expressed as medians (range) for continuous variables and numbers (%) for categorical variables. Results Among the 562 registry patients, 265 (49.6%) were females; 454 (85.0%) had type 1, 22 (4.1%) type 2, 37 (6.9%) perinatal–lethal type and 21 (3.9%) type 3. Median ages at first GD symptoms and diagnosis, respectively, were 15 (0–77) and 22 (0–84) years for all types. The first symptom diagnosing GD was splenomegaly and/or thrombocytopenia (37.6% and 26.3%, respectively). Bone-marrow aspiration and/or biopsy yielded the diagnosis for 54.7% of the patients, with enzyme deficiency confirming GD for all patients. Birth incidence rate was estimated at 1/50,000 and prevalence at 1/136,000. For the 378 followed patients, median follow-up was 16.2 (0.1–67.6) years. Major clinical complications were bone events (BE; avascular necrosis, bone infarct or pathological fracture) for 109 patients, splenectomy for 104, and Parkinson’s disease for 14; 38 patients died (neurological complications for 15 type-2 and 3 type-3 patients, GD complications for 11 type-1 and another disease for 9 type-1 patients). Forty-six had monoclonal gammopathy. Among 283 recently followed patients, 36 were untreated and 247 had been treated during 2009–2010; 216 patients received treatment in December 2010 (126 with imiglucerase, 45 velaglucerase, 24 taliglucerase, 21 miglustat). BE occurred before (130 in 67 patients) and under treatment (60 in 41 patients) with respective estimated frequencies (95% CI) of first BE at 10 years of 20.3% (14.1%–26.5%) and 19.8% (13.5%–26.1%). Conclusion This registry enabled the epidemiological description of GD in France and showed that BE occur even during treatment.

Published
2012
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65. Travel-related health events and their risk factors in HIV-infected sub-Saharan migrants living in France and visiting their native country: The ANRS VIHVO cohort study

Author

Pistone, Thierry, primary, Ouattara, Eric, additional, Gabillard, Delphine, additional, Lele, Nathalie, additional, Duvignaud, Alexandre, additional, Cordel, Hugues, additional, Malvy, Denis, additional, Bouchaud, Olivier, additional, Abgrall, Sophie, additional, Bentata, Michele, additional, Fantin, Bruno, additional, Goujard, Cécile, additional, Matheron, Sophie, additional, Launay, Odile, additional, Le Moing, Vincent, additional, Lortholary, Olivier, additional, Consigny, Paul- Henri, additional, Saada, Matthieu, additional, Katlama, Christine, additional, Simon, Anne, additional, Arvieux, Cédric, additional, Campa, Pauline, additional, Girard, Pierre-Marie, additional, Khuong, Marie-Aude, additional, Molina, Jean-Michel, additional, Lascoux-Combe, Caroline, additional, Rey, David, additional, Rondeau, Murielle, additional, Pialoux, Gilles, additional, Couzigou, Carine, additional, Vittecoq, Daniel, additional, Patey, Olivier, additional, Morlat, Philippe, additional, Duong, Michel, additional, and Chavanet, Pascal, additional

Published
2019
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69. Characteristics of and risk factors for severe neurological deficit in patients with pyogenic vertebral osteomyelitis: A case-control study

Author

Lemaignen, Adrien, Ghout, Idir, Dinh, Aurélien, Gras, Guillaume, Fantin, Bruno, Zarrouk, Virginie, Carlier, Robert, Loret, Jean-Edouard, Denes, Eric, Greder, Alix, Lescure, François-Xavier, Boutoille, David, Tattevin, Pierre, Issartel, Bertrand, Cottier, Jean-Philippe, Bernard, Louis, Bernard, Adrien, Service de Médecine Interne et Maladies Infectieuses [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Clinic Research Unit Boulogne, University Hospital A Pare, Services des maladies infectieuses [AP-HP Hôpital Raymond Poincaré, Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], Laboratoire de Mathématiques de Besançon (UMR 6623) (LMB), Université de Bourgogne (UB)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Dpt médecine interne [CHU Beaujon], Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [AP-HP], Service de Neurochirurgie [CHRU Tours], Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges, Service des Maladies Infectieuses [CH de Versailles André Mignot], Centre Hospitalier de Versailles André Mignot (CHV), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Department of Infectious Diseases Clinique du Parc Lyon, Clinique Résidence du Parc, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Michel, Geneviève, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP Hôpital Raymond Poincaré [Garches], Laboratoire de Mathématiques de Besançon, Chercheur indépendant, Hôpital Beaujon, AP-HP Hôpital Raymond Poincaré [Garches], Centre Hospitalier de Versailles (CHV), Service des maladies infectieuses et réanimation médicale, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Imagerie et cerveau, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (Polytech Nantes), Centre Hospitalier Régional Universitaire de Tours ( CHRU TOURS ), Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP Hôpital Raymond Poincaré [Garches], Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ), Centre Hospitalier de Versailles André Mignot, Infection, Antimicrobiens, Modélisation, Evolution ( IAME ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou, Université de Tours-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Recherche en Communications et en Cybernétique de Nantes ( IRCCyN ), Mines Nantes ( Mines Nantes ) -École Centrale de Nantes ( ECN ) -Ecole Polytechnique de l'Université de Nantes ( Polytech Nantes ), and Université de Nantes ( UN ) -Université de Nantes ( UN ) -PRES Université Nantes Angers Le Mans ( UNAM ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Male, medicine.medical_specialty, Epidural abscess, [SDV.IMM] Life Sciences [q-bio]/Immunology, Observational Study, 03 medical and health sciences, 0302 clinical medicine, neurologic manifestations, Spinal cord compression, Internal medicine, spinal cord compression, medicine, Vertebral osteomyelitis, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Humans, risk factors, 030212 general & internal medicine, Retrospective Studies, business.industry, Osteomyelitis, Hazard ratio, vertebral osteomyelitis, Case-control study, Retrospective cohort study, General Medicine, Odds ratio, Middle Aged, Staphylococcal Infections, medicine.disease, 3. Good health, Surgery, Anti-Bacterial Agents, Treatment Outcome, Epidural Abscess, Case-Control Studies, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Spinal Diseases, France, Nervous System Diseases, business, 030217 neurology & neurosurgery, Follow-Up Studies, Research Article
Abstract

Supplemental Digital Content is available in the text, Severe neurological deficit (SND) is a rare but major complication of pyogenic vertebral osteomyelitis (PVO). We aimed to determine the risk factors and the variables associated with clinical improvement for SND during PVO. This case–control study included patients without PVO-associated SND enrolled in a prospective randomized antibiotic duration study, and patients with PVO-associated SND managed in 8 French referral centers. Risk factors for SND were determined by logistic regression. Ninety-seven patients with PVO-associated SND cases, and 297 controls were included. Risk factors for SND were epidural abscess [adjusted odds ratio, aOR 8.9 (3.8–21)], cervical [aOR 8.2 (2.8–24)], and/or thoracic involvement [aOR 14.8 (5.6–39)], Staphylococcus aureus PVO [aOR 2.5 (1.1–5.3)], and C-reactive protein (CRP) >150 mg/L [aOR 4.1 (1.9–9)]. Among the 81 patients with PVO-associated SND who were evaluated at 3 months, 62% had a favorable outcome, defined as a modified Rankin score ≤ 3. No factor was found significantly associated with good outcome, whereas high Charlson index [adjusted Hazard Ratio (aHR) 0.3 (0.1–0.9)], low American Spinal Injury Association (ASIA) impairment scale at diagnosis [aHR 0.4 (0.2–0.9)], and thoracic spinal cord compression [aHR 0.2 (0.08–0.5)] were associated with poor outcome. Duration of antibiotic treatment was not associated with functional outcome. SND is more common in cervical, thoracic, and S. aureus PVO, in the presence of epidural abscess, and when CRP >150 mg/L. Although neurological deterioration occurs in 30% of patients in early follow-up, the functional outcome is quite favorable in most cases after 3 months. The precise impact of optimal surgery and/or corticosteroids therapy must be specified by further studies.

Published
2017

70. More complications in cervical than in non-cervical spine tuberculosis.

Author

Pourbaix, Annabelle, Zarrouk, Virginie, Allaham, Wassim, Leflon, Véronique, Rousseau, Marc-Antoine, Goutagny, Stephane, Guigui, Pierre, and Fantin, Bruno

Subjects
SPINAL tuberculosis, CERVICAL vertebrae, SPINAL surgery, DEMOGRAPHIC characteristics, TUBERCULOSIS patients, TERTIARY care
Abstract

Purpose: Cervical spine tuberculosis (CST) is a rare disease that may lead to severe neurological complications. The goal of the study was to compare the characteristics of patients with CST with those of patients with non-cervical spine tuberculosis (NCST). Methods: Between 1997 and 2016, we reviewed all cases of proven tuberculosis from a cohort of spine infections in a tertiary care hospital. Clinical, biological, and imaging data were collected at baseline and after treatment. Results: Fifty-one cases of spine tuberculosis were included: 14 with CST on imaging (27%) and 37 with no cervical localization. Median age was 39 y. Demographic characteristics, duration of symptoms and neurological findings of spine compression were similarly present at presentation in CST and NCST patients. On imaging, lesions were more often multifocal in CST than in NCST patients (9/14 [64%] versus 10/37 [27%], p =.014). Spinal surgery was required in 32/51 (63%) patients. At the end of follow-up (median: 20 months), cure rates were similar in CST and NCST patients but motor and/or sensitive functional sequel were more frequent in CST than NCST patients (6/14 [43%] versus 2/37 [5%], p =.003). Conclusions: Cervical involvement is present in more than a quarter of patients with spinal tuberculosis. Patients with CST had more frequent neurological sequelae than patients with NCST. This was mainly due to a more multifocal disease at presentation. Screening for cervical localization should be systematic in patients with spinal tuberculosis even in the absence of cervical symptoms. [ABSTRACT FROM AUTHOR]

Published
2020
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71. Prediction of the intestinal resistome by a three-dimensional structure-based method

Author

Ruppé, Etienne, primary, Ghozlane, Amine, additional, Tap, Julien, additional, Pons, Nicolas, additional, Alvarez, Anne-Sophie, additional, Maziers, Nicolas, additional, Cuesta, Trinidad, additional, Hernando-Amado, Sara, additional, Clares, Irene, additional, Martínez, Jose Luís, additional, Coque, Teresa M., additional, Baquero, Fernando, additional, Lanza, Val F., additional, Máiz, Luis, additional, Goulenok, Tiphaine, additional, de Lastours, Victoire, additional, Amor, Nawal, additional, Fantin, Bruno, additional, Wieder, Ingrid, additional, Andremont, Antoine, additional, van Schaik, Willem, additional, Rogers, Malbert, additional, Zhang, Xinglin, additional, Willems, Rob J. L., additional, de Brevern, Alexandre G., additional, Batto, Jean-Michel, additional, Blottière, Hervé M., additional, Léonard, Pierre, additional, Léjard, Véronique, additional, Letur, Aline, additional, Levenez, Florence, additional, Weiszer, Kevin, additional, Haimet, Florence, additional, Doré, Joël, additional, Kennedy, Sean P., additional, and Ehrlich, S. Dusko, additional

Published
2018
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75. HypervirulentKlebsiella pneumoniaein Cryptogenic Liver Abscesses, Paris, France

Author

Rossi, Benjamin, primary, Gasperini, Maria Ludovica, additional, Leflon-Guibout, Véronique, additional, Gioanni, Alice, additional, de Lastours, Victoire, additional, Rossi, Geoffrey, additional, Dokmak, Safi, additional, Ronot, Maxime, additional, Roux, Olivier, additional, Nicolas-Chanoine, Marie-Hélène, additional, Fantin, Bruno, additional, and Lefort, Agnès, additional

Published
2018
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76. Prediction of the intestinal resistome by a novel 3D-based method

Author

Ruppé, Etienne, primary, Ghozlane, Amine, additional, Tap, Julien, additional, Pons, Nicolas, additional, Alvarez, Anne-Sophie, additional, Maziers, Nicolas, additional, Cuesta, Trinidad, additional, Hernando-Amado, Sara, additional, Martínez, Jose Luís, additional, Coque, Teresa M., additional, Baquero, Fernando, additional, Lanza, Val F., additional, Maiz, Luis, additional, Goulenok, Tiphaine, additional, Lastours, Victoire de, additional, Amor, Nawal, additional, Fantin, Bruno, additional, Wieder, Ingrid, additional, Andremont, Antoine, additional, Schaik, Willem van, additional, Rogers, Malbert, additional, Zhang, Xinglin, additional, Willems, Rob J.L., additional, De Brevern, Alexandre G., additional, Batto, Jean-Michel, additional, Blottière, Hervé, additional, Léonard, Pierre, additional, Léjard, Véronique, additional, Letur, Aline, additional, Levenez, Florence, additional, Weiszer, Kevin, additional, Haimet, Florence, additional, Doré, Joël, additional, Kennedy, Sean P., additional, and Dusko Ehrlich, S., additional

Published
2017
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82. The French Gaucher Disease Registry: Clinical characteristics, complications and treatment of 616 patients

Author

Stirnemann, Jerome, primary, Hamroun, Dalil, additional, Bengherbia, Monia, additional, Yousfi, Karima, additional, Berger, Juliette, additional, Brassier, Anais, additional, Broissand, Christine, additional, Caillaud, Catherine, additional, Camou, Fabrice, additional, Dalbies, Florence, additional, Dobbelaere, Dries, additional, Froissart, Roseline, additional, Grosbois, Bernard, additional, Leguy-Seguin, Vanessa, additional, Levade, Thierry, additional, Masseau, Agathe, additional, Rose, Christian, additional, Serratrice, Christine, additional, Valayannopoulos, Vassili, additional, Fantin, Bruno, additional, Berger, Marc, additional, de Villemeur, Thierry Billette, additional, and Belmatoug, Nadia, additional

Published
2016
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84. Costs associated with implementation of a strict policy for controlling spread of highly resistant microorganisms in France

Author

Birgand, Gabriel, primary, Leroy, Christophe, additional, Nerome, Simone, additional, Luong Nguyen, Liem Binh, additional, Lolom, Isabelle, additional, Armand-Lefevre, Laurence, additional, Ciotti, Céline, additional, Lecorre, Bertrand, additional, Marcade, Géraldine, additional, Fihman, Vincent, additional, Nicolas-Chanoine, Marie-Hélène, additional, Pelat, Camille, additional, Perozziello, Anne, additional, Fantin, Bruno, additional, Yazdanpanah, Yazdan, additional, Ricard, Jean-Damien, additional, and Lucet, Jean-Christophe, additional

Published
2016
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85. Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus b19 infection: a retrospective study of 10 patients and review of the literature

Author

Legendre Christophe, Yoann Crabol, Catherine Montagnier-Petrissans, Marjanovic Zora, Fischer Alain, Papo Thomas, Olivier Hermine, Le Parc Jean-Marie, Flore Rozenberg, Paré Hôpital Ambroise, Godeau Bertrand, Necker Hôpital, Montagnier-Petrissan Catherine, Mouthon Luc, Fantin Bruno, Bussel Annette, Benjamin Terrier, Hermine Olivier, Lesavre Philippe, Lortholary Olivier, Gorin Norbert-Claude, Dreyfus François, Fermand Jean-Paul, Benomar Amina, Parquet Nathalie, Christophe Legendre, Sharshar Tarek, Fontaine Bertrand, Guillevin Loïc, Charpentier Bernard, Loïc Guillevin, Sauvageon Hélène, Liou Amélie, Leverger Guy, Lopez Isabelle, Piette Jean-Charles, Bicêtre Hôpital, Luc Mouthon, Oksenhendler Eric, and Vincent Pestre

Subjects
Microbiology (medical), Adult, Male, medicine.medical_specialty, Paris, Adolescent, viruses, Pure red cell aplasia, Red-Cell Aplasia, Pure, Gastroenterology, Parvoviridae Infections, Intravenous Immunoglobulin Therapy, hemic and lymphatic diseases, Internal medicine, medicine, Parvovirus B19, Human, Humans, Aplastic anemia, Aged, Retrospective Studies, biology, business.industry, virus diseases, Immunoglobulins, Intravenous, Retrospective cohort study, Middle Aged, medicine.disease, Pulmonary edema, Surgery, Infectious Diseases, medicine.anatomical_structure, Treatment Outcome, biology.protein, Female, Hemoglobin, Bone marrow, Immunotherapy, Antibody, business
Abstract

Background. We evaluated the efficacy of intravenous immunoglobulin (IVIG) therapy in patients with pure red cell aplasia (PRCA) related to human parvovirus B19 (HPV-B19) infection. Methods. We retrospectively reviewed all HPV-B19 PRCA cases treated with IVIG between January 2000 and December 2005 in the Assistance Publique-Hopitaux de Paris hospitals and reviewed all cases of HPV-B19 PRCA cases treated with IVIG in the literature. Results. Among our 36 patients, PRCA was confirmed in 22, including 10 with proven HPV-B19 infection. Nine patients were immunocompromised, including 4 who had undergone transplant. All patients had severe anemia (mean hemoglobin level, 5.0 ± 1.9 g/dL). Seven patients who underwent bone-marrow aspiration had positive HPV-B19 polymerase chain reaction (PCR) results at diagnosis. Patients received a mean of 2.7 ± 2.1 IVIG courses (1.3 ± 0.5 g/kg/course). Hemoglobin level was corrected in 9 of the 10 patients within a mean of 80 ± 54 days. The only nonresponsive patient had underlying myelodysplasia. Blood HPV-B19 PCR results were negative from 35 to 159 days after treatment. Four patients showed side effects of IVIG treatment: acute reversible renal failure (n = 2) and pulmonary edema (n = 2). Among 133 patients with HPV-B19 PRCA who received IVIG (our 10 patients and 123 from the literature), 63 had undergone solid-organ transplant and 39 had human immunodeficiency virus infection. Hemoglobin level was corrected after the first IVIG course in 124 patients (93%); disease relapsed in 42 (33.9%), at a mean of 4.3 months. Conclusions. IVIG therapy appears to be effective in the short term in immunocompromised patients with HPV-B19 PRCA.

Published
2012

88. Ecological impact of ciprofloxacin on commensal enterococci in healthy volunteers.

Author

de Lastours, Victoire, Maugy, Elena, Mathy, Vincent, Chau, Françoise, Rossi, Benjamin, Guérin, François, Cattoir, Vincent, Fantin, Bruno, and CIPHARES Study Group

Subjects
CIPROFLOXACIN, ENTEROCOCCUS, FLUOROQUINOLONES, POLYMORPHIC transformations, POLYMERASE chain reaction, FECES, MICROBIOLOGY, GUT microbiome, COMPARATIVE studies, DRUG resistance in microorganisms, ENZYMES, GASTROINTESTINAL system, MASS spectrometry, RESEARCH methodology, MEDICAL cooperation, MICROBIAL sensitivity tests, GENETIC mutation, RESEARCH, EVALUATION research, PHENOMENOLOGICAL biology, HUMAN research subjects, ENTEROCOCCUS faecium, SEQUENCE analysis, PHARMACODYNAMICS
Abstract

Background: The ecological impact of ciprofloxacin on commensal enterococci is unknown.Methods: Forty-eight healthy volunteers received ciprofloxacin from day (D) 0 to D14; stools were collected on D7, D14 and D42. Fluoroquinolone-susceptible and -resistant enterococci (FQ-SE and FQ-RE) were detected and quantified by culture, and identified by MALDI-TOF MS. The relative abundance of FQ-RE over FQ-SE was determined. The genetic basis of fluoroquinolone resistance was deciphered by partial sequencing of gyrA and parC genes. Clonal relatedness was determined by random amplification of polymorphic DNA PCR. Clinical trial no.: NCT00190151.Results: Enterococci were carried by 47/48 (98%) subjects. Total counts were reduced during ciprofloxacin therapy (4.0 and 3.9 log cfu/g on D7 and D14 versus 5.9 log cfu/g before and 6.9 log cfu/g after treatment; P  < 0.05). Twenty-one out of 48 (44%) carried FQ-RE; among them, 21/21 carried Enterococcus faecium , 19 carried Enterococcus faecalis and 11 carried other species. Five out of 48 (10%) harboured FQ-RE (ciprofloxacin MIC >4 mg/L) before treatment (all E. faecium ), 6 on D7 (3 E. faecium and 3 E. faecalis ), 8 on D14 (4 E. faecium and 4 E. faecalis ) and 10 (21%) on D42 (9 E. faecium and 1 E. faecalis ). The relative abundance of FQ-RE increased from 44% on D0 to 73% and 75% on D7 and D14, respectively. No acquisition of fluoroquinolone resistance among endogenous D0 strains was evidenced. All (14/14) distinct Fluoroquinolone-resistant E. faecalis clones were gyrA / parC double mutants with high-level resistance (ciprofloxacin MIC >64 mg/L). In contrast, 34/35 E. faecium exhibited low-level resistance (ciprofloxacin MIC 4-32 mg/L) with no gyrA / parC mutation, but overexpressed the chromosomal Efm qnr gene. As compared with Fluoroquinolone-susceptible strains, Fluoroquinolone-resistant E. faecium were more frequently ampicillin resistant and Fluoroquinolone-resistant E. faecalis were more highly resistant to gentamicin.Conclusions: Although intrinsically poorly susceptible to fluoroquinolones, gut populations of enterococci are highly impacted both quantitatively and qualitatively by ciprofloxacin. [ABSTRACT FROM AUTHOR]

Published
2017
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89. Behcet’s disease in budd-chiari syndrome

Author

Desbois, Anne Claire, primary, Rautou, Pierre Emmanuel, additional, Biard, Lucie, additional, Belmatoug, Nadia, additional, Wechsler, Bertrand, additional, Resche-Rigon, Mathieu, additional, Zarrouk, Virginie, additional, Fantin, Bruno, additional, de Chambrun, M Pineton, additional, Cacoub, Patrice, additional, Valla, Dominique, additional, Saadoun, David, additional, and Plessier, Aurélie, additional

Published
2014
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93. Reply to M.R. Green et al

Author

Cornely, Oliver A., primary, Miller, Mark A., additional, Fantin, Bruno R., additional, Mullane, Kathleen M., additional, Kean, Yin, additional, and Gorbach, Sherwood L., additional

Published
2013
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96. Clinical Outcome After a Totally Implantable Venous Access Port-Related Infection in Cancer Patients

Author

Lebeaux, David, primary, Larroque, Béatrice, additional, Gellen-Dautremer, Justine, additional, Leflon-Guibout, Véronique, additional, Dreyer, Chantal, additional, Bialek, Suzanne, additional, Froissart, Antoine, additional, Hentic, Olivia, additional, Tessier, Catherine, additional, Ruimy, Raymond, additional, Pelletier, Anne-Laure, additional, Crestani, Bruno, additional, Fournier, Michel, additional, Papo, Thomas, additional, Barry, Béatrix, additional, Zarrouk, Virginie, additional, and Fantin, Bruno, additional

Published
2012
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99. Tuberculous cerebral vasculitis: Retrospective study of 10 cases

Author

Javaud, Nicolas, primary, Certal, Rita Da Silva, additional, Stirnemann, Jérôme, additional, Morin, Anne-Sophie, additional, Chamouard, Jean-Marie, additional, Augier, Alexandre, additional, Bouchaud, Olivier, additional, Carpentier, Antoine, additional, Dhote, Robin, additional, Dumas, Jean-Luc, additional, Fantin, Bruno, additional, and Fain, Olivier, additional

Published
2011
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