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72 results on '"Fan, Zhixin"'

53. Monocrotaline pyrrole enhanced bone morphogenetic protein 7 signaling transduced by alternative activin A receptor type 2A in pulmonary arterial smooth muscle cells

Author

Bingxiang Wu, Xiaohan Cheng, Bo Yu, Xiaodong Zheng, Binfeng Sun, Fan Zhixin, Fangli Yu, Yiqiang Chen, Na Sun, and Jianhui Lin

Subjects
0301 basic medicine, animal structures, Metabolite, Activin Receptors, Type II, Bone Morphogenetic Protein 7, Myocytes, Smooth Muscle, Pulmonary Artery, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Western blot, medicine.artery, medicine, Animals, Humans, Cell Proliferation, Pharmacology, Gene knockdown, Monocrotaline, biology, medicine.diagnostic_test, Cell Cycle, medicine.disease, Pulmonary hypertension, Proliferating cell nuclear antigen, Rats, Bone morphogenetic protein 7, 030104 developmental biology, chemistry, Gene Knockdown Techniques, embryonic structures, Pulmonary artery, Cancer research, biology.protein, Phosphorylation, 030217 neurology & neurosurgery, Signal Transduction
Abstract

Background Increased expression levels of bone morphogenetic protein 7 (BMP7) are associated with poor prognosis in pulmonary hypertension patients. However, whether BMP7 signaling conspire to involve in the proliferation of pulmonary artery smooth muscle cells (PASMC) underlying monocrotaline (MCT) induced pulmonary arterial hypertension (PAH) remain unclear. Methods and Results Western blot experiments found BMP7 was increased in pulmonary arteries isolated from MCT-PAH rat. In addition, monocrotaline pyrrole (MCTP), the putative toxic metabolite of the MCT, increases the expression of BMP7, proliferating cell nuclear antigen (PCNA) and activin A receptor type 2A, but decreases bone morphogenetic protein receptor type 2 in cultured pulmonary artery smooth muscle cells (PASMC). In PASMCs, exogenous BMP7 leads to the decreasing expression of activin A receptor type 2, increasing phosphorylation of p38MAPK and elevation of P21. However, BMP7 treatment results in the increasing expression of activin A receptor type 2A, p38MAPK, and PCNA in bone morphogenetic protein receptor type 2 knockdown PASMCs. Knockdown of activin A receptor type 2A abrogated the MCTP-induced PCNA and cell cycle progression. Conclusions MCTP treatment lead to the expression of BMP7, suppression of bone morphogenetic protein receptor type 2 but increasing expression of activin A receptor type 2A, the BMP7 mediated PASMC proliferation via preferential activation of an activin A receptor type 2A signaling axis.

Published
2019

58. Ideal Model of Polymer Dispersed Liquid Crystal for Enhanced Scattering

Author

张翠云 Zhang Cuiyun, 李婧 Li Jing, 于天池 Yu Tianchi, and 范志新 Fan Zhixin

Subjects
chemistry.chemical_classification, Materials science, Ideal (set theory), chemistry, Polymer nanocomposite, Chemical engineering, Scattering, Liquid crystal, Polymer, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published
2008
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66. Polarization Microscopy Study on Piezo-Optical Effect of Polymer Dispersed Liquid Crystal Films

Author

赵永芳 Zhao Yongfang, 范志新 Fan Zhixin, 孙玉宝 Sun Yubao, 黎振远 Li Zhenyuan, and 李金炜 Li Jinwei

Subjects
chemistry.chemical_classification, Materials science, Optics, chemistry, Liquid crystal, business.industry, Polarization Microscopy, Optoelectronics, Polymer, business, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published
2011
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69. The Roles of Different Multigene Combinations of Pdx1, Ngn3, Sox9, Pax4, and Nkx2.2in the Reprogramming of Canine ADSCs Into IPCs

Author

Gao, Dengke, Dai, Pengxiu, Fan, Zhixin, Wang, Jinglu, and Zhang, Yihua

Abstract

Adipose-derived mesenchymal stem cells (ADSCs) are ideal sources for the treatment of diabetes, and the differentiation of ADSCs into insulin-producing cells (IPCs) through transfection of exogenous regulatory genes in vitrohas been studied in depth. The differentiation of ADSCs is strictly regulated by a variety of transcription factors such as Pdx1, Ngn3, Pax4, Nkx2.2, and Sox9. However, whether these genes can coordinately regulate the differentiation of ADSCs into IPCs is still unknown. In this study, five multigene coexpressing adenovirus vectors (pAdTrack-Pdx1-Ngn3-AdEasy, pAdTrack-Pdx1-Ngn3-Sox9-AdEasy, pAdTrack-Pdx1-Ngn3-Pax4-Sox9-AdEasy, pAdTrack-Pdx1-Ngn3-Nkx2.2-Sox9-AdEasy, and pAdTrack-Pdx1-Ngn3-Nkx2.2-Pax4-AdEasy) were constructed, and then the stocks of the packaged adenoviruses were used to infect the canine ADSCs (cADSCs). Based on results of morphological observation, dithizone staining, sugar-stimulated insulin secretion test, cellular insulin immunofluorescence assays, and the detection of pancreatic β-cell development–related genes in the induced cells, the best induction combination (pAdTrack-Pdx1-Ngn3-Nkx2.2-Pax4-AdEasy) was identified after comparative screening. This study provides a theoretical reference and an experimental basis for further research on stem cell replacement therapy for diabetes.

Published
2022
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71. Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats.

Author

Wu S, Zhu L, Yang J, Fan Z, Dong Y, Luan R, Cai J, and Fu L

Subjects
Animals, Autophagy drug effects, Blotting, Western, Echocardiography, Heart Failure diagnostic imaging, Hydrogen chemistry, Male, Microscopy, Electron, Transmission, Myocardium pathology, Oxidative Stress drug effects, Pharmaceutical Solutions, Rats, Rats, Wistar, Survival, Ventricular Function, Left drug effects, Antibiotics, Antineoplastic antagonists & inhibitors, Antibiotics, Antineoplastic toxicity, Cardiotonic Agents, Doxorubicin antagonists & inhibitors, Doxorubicin toxicity, Heart Failure chemically induced, Heart Failure prevention & control, Hydrogen pharmacology, Sodium Chloride chemistry
Abstract

Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.

Published
2014

72. [The theoretical calculation for optimal doping content of blood compatible titanium oxide films].

Author

Gao H and Fan Z

Subjects
Materials Testing, Membranes, Artificial, Biocompatible Materials chemistry, Mathematical Computing, Titanium chemistry
Abstract

The quantitative theory of optimal doping content of transparent conductive films is introduced in this paper. In this theory, the relationship among the physical properties and crystal structure, preparation method and doping content is set up. The parabola equation that can be fixed to test curve and that has the reliable physical meaning is given. The extreme value of this equation confirms the quantitative relationship between the optimal doping content, the crystal structure and the preparation method. This an expression of the optimal doping content is obtained. The experimental results of doping modified for blood compatibility of titanium oxide films are analyzed. Using this expression to calculate the Ta5+ optimal doping content in blood compatibility of titanium oxide films.

Published
2002

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