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55. Volumetric assessment is superior to axial measurements in estimating the outcome of patients with acute uncomplicated type B aortic intramural haematoma

Author

Chen, Min, primary, Yang, Fan, additional, Chen, Lyufan, additional, Liu, Jitao, additional, Luo, Songyuan, additional, Li, Jie, additional, Huang, Wenhui, additional, Liu, Yuan, additional, Fan, Ruixin, additional, Geng, Qingshan, additional, Chen, Jiyan, additional, and Luo, Jianfang, additional

Published
2022
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62. Machine Learning Prediction Model for Acute Renal Failure After Acute Aortic Syndrome Surgery

Author

Li, Jinzhang, primary, Gong, Ming, additional, Joshi, Yashutosh, additional, Sun, Lizhong, additional, Huang, Lianjun, additional, Fan, Ruixin, additional, Gu, Tianxiang, additional, Zhang, Zonggang, additional, Zou, Chengwei, additional, Zhang, Guowei, additional, Qian, Ximing, additional, Qiao, Chenhui, additional, Chen, Yu, additional, Jiang, Wenjian, additional, and Zhang, Hongjia, additional

Published
2022
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63. The Role of Surgeon's Intuition for Acute Type a Aortic Dissection In an Era of Evidence-Based Medicine: A Prospective Study

Author

Wu, Jinlin, primary, Chen, Zerui, additional, Li, Chenxi, additional, Chen, Julia Fayanne, additional, Zhu, Jiade, additional, Li, Huili, additional, Wang, Qiuji, additional, Wu, Yanfen, additional, Yu, Changjiang, additional, Yang, Jue, additional, Li, Xin, additional, Liu, Jie, additional, Cheng, Yunqing, additional, Fan, Ruixin, additional, and Sun, Tucheng, additional

Published
2022
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64. Outcomes Of Chimney Technique For Aortic Arch Diseases: A Single-Center Experience With 226 Cases

Author

Huang, Wenhui, Ding, Huanyu, Jiang, Minchun, Liu, Yuan, Huang, Cheng, Yang, Xinyue, Fan, Ruixin, Luo, Jianfang, and Jiang, Zhisheng

Subjects
Adult, Male, Time Factors, Aortic Aneurysm, Thoracic, Aortic Rupture, Endovascular Procedures, Aortic Diseases, endoleak, Aorta, Thoracic, Middle Aged, aortic arch disease, Blood Vessel Prosthesis, thoracic endovascular aortic repair, Aortic Dissection, Blood Vessel Prosthesis Implantation, Treatment Outcome, Clinical Interventions in Aging, Humans, Female, chimney, Original Research, Aged, Retrospective Studies
Abstract

Wenhui Huang,1,2,* Huanyu Ding,2,* Minchun Jiang,3,* Yuan Liu,2 Cheng Huang,2 Xinyue Yang,2,4,5 Ruixin Fan,6 Jianfang Luo,2,4,5 Zhisheng Jiang1 1Institute of Cardiovascular Disease and Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of China; 2Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China; 3School of Biomedical Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong, People’s Republic of China; 4Guangdong Provincial People’s Hospital affiliated to South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 5School of Medicine, South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 6Department of Cardiovascular Surgery, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhisheng JiangInstitute of Cardiovascular Disease and Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of ChinaEmail drzhishengjiang@126.comPurpose: The goal of present study is to document our single-center experience with chimney technique for aortic arch diseases.Patients and methods: From August 2012 to October 2017, 226 patients (mean age 54±12 years; 197 men) with aortic arch diseases underwent thoracic endovascular aortic repair combined with chimney stents. The aortic stent-grafts were deployed in zone 0 (n=22), zone 1 (n=13), or zone 2 (n=191).Results: The technical success rate was 84% (189/226) and immediate type Ia endoleak (ELIa) happened in 37 (16%) patients. The 30-day mortality and morbidity rates were 2% (4/226) and 4% (8/226), respectively. Major adverse events include four major strokes, three spinal cord ischemia and one aortic rupture in the early-term. The clinical and imaging follow-up rates were 98% (218/222) and 78% (173/222), respectively. The average lengths of clinical and imaging follow-up were 22±16 months and 20±15 months, respectively. Chimney stent obstructions in left subclavian arteries were recorded in six (3%) patients. During follow-up, five patients died (2%) and two major strokes occurred (1%). One patient (0.5%) underwent reintervention.Conclusion: The current study documented that the chimney technique is effective and safe for treating aortic arch diseases in different aortic zones. Cautions are needed to assess the permanency of chimney stent and to reduce the immediate ELIa rate.Keywords: aortic arch disease, chimney, endoleak, thoracic endovascular aortic repair

Published
2019

65. Analysis of the contribution of 129 candidate genes to thoracic aortic aneurysm or dissection of a mixed cohort of sporadic and familial cases in South China

Author

Li, Ying, Fang, Miaoxian, Yang, Jue, Yu, Changjiang, Kuang, Juntao, Sun, Tucheng, and Fan, Ruixin

Subjects
Original Article
Abstract

Thoracic aortic aneurysm or dissection (TAAD) is a group of life-threatening complex diseases after symptomatic onset with genetic heterogeneity accounting for approximately 20% of cases. Previously, we identified 40 rare variants in 11 TAAD-related core genes among 70 TAAD patients by next-generation sequencing. In this study, we further analyzed the variants in the disease-causing genes in 129 cases of sporadic TAAD and 22 familial cases by whole-exome sequencing. A total of 116 variants in 47 TAAD-related genes were identified, 64.7% (75/116) of which occurred in sporadic TAAD without syndromes, and among these genes, FBN1 was the most common TAAD-related gene. Of the 26.7% (31/116) that were pathogenic or likely pathogenic, almost one third were from sporadic cases without syndromes involving FBN1, SMAD3, SMAD6, MYH11, TGFBR1, MYLK, LOX and LTBP3. Interestingly, the novel VUS (variant of uncertain significance) *879Glu in MCTP2 occurred in two unrelated probands with sporadic acute aortic dissection without a bicuspid aortic valve. Furthermore, more than one variant was detected in 24 patients, and 70.8% (17/24) occurred in sporadic cases. Younger individuals were more likely to carry P/LP (pathogenic or likely pathogenic) variants and harbor more variants. P/LP carriers seem to have a larger aortic diameter, lower D-dimer levels, and a shorter ICU length of stay but longer hospitalization time. In conclusion, we expanded the candidate gene profile of TAAD, especially for sporadic cases without syndromic features. VUSs need further clarification.

Published
2021

69. Supplemental Material, sj-pdf-1-ang-10.1177_00033197211012514 - Impact of Lymphocyte-Related Blood Parameters on Short- and Long-Term Outcomes of Patients Undergoing Thoracic Endovascular Aortic Repair

Author

Yang, Fan, Liu, Jitao, Chen, Lyufan, Fan, Ruixin, Zeng, Hongke, Geng, Qingshan, and Luo, Jianfang

Subjects
cardiovascular system, Cardiology
Abstract

Supplemental Material, sj-pdf-1-ang-10.1177_00033197211012514 for Impact of Lymphocyte-Related Blood Parameters on Short- and Long-Term Outcomes of Patients Undergoing Thoracic Endovascular Aortic Repair by Fan Yang, Jitao Liu, Lyufan Chen, Ruixin Fan, Hongke Zeng, Qingshan Geng and Jianfang Luo in Angiology

Published
2021
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74. Anatomical Predictors of Valve Malposition During Self-Expandable Transcatheter Aortic Valve Replacement

Author

Li, Jie, primary, Sun, Yinghao, additional, Zheng, Shengneng, additional, Li, Guang, additional, Dong, Haojian, additional, Fu, Ming, additional, Mo, Yujing, additional, Li, Yi, additional, Liu, Huadong, additional, Xu, Zhaoyan, additional, Zhang, Liting, additional, Cao, Yong, additional, Fan, Ruixin, additional, Lim, D. Scott, additional, and Luo, Jianfang, additional

Published
2021
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88. Effect of iron on oxygen precipitation in nitrogen-doped Czochralski silicon

Author

Zhang, Xiwen, Yang, Deren, Fan, Ruixin, Zhang, Jinxin, and Que, Duanlin

Subjects
Semiconductor doping -- Analysis, Silicon -- Analysis, Physics
Abstract

The effects of iron on oxygen precipitation in nitrogen-doped Czocharlski (NCZ) silicon and CZ silicon are studied. Results show that oxygen precipitation in CZ silicon and NCZ silicon were increased by iron and nitrogen impurities, respectively. Iron had no affect on oxygen precipitation at high temperatures in NCZ, but suppressed the nucleation of oxygen precipitation during annealing at low temperatures.

Published
1998

89. Outcomes of preoperative antiplatelet therapy in patients with acute type A aortic dissection.

Author

Jiang, Xuan, Khan, Fareed, Shi, Enyi, Fan, Ruixin, Qian, Ximing, Zhang, Hongjia, and Gu, Tianxiang

Subjects
AORTIC dissection, CHEST pain, BLOOD platelet transfusion, ACUTE coronary syndrome, INDUCED cardiac arrest, OVERALL survival, PERCUTANEOUS coronary intervention, ERYTHROCYTES
Abstract

Background: Acute type A aortic dissection (ATAAD) is life‐threatening and requires immediate surgery. Sudden chest pain may lead to a risk of misdiagnosis as an acute coronary syndrome and may lead to subsequent antiplatelet therapy (APT). We used the Chinese Acute Aortic Syndrome (AAS) Collaboration Database to study the effects of APT on clinical outcomes. Methods: The AAS database is a retrospective multicentre database where 31 of 3092 patients had APT with aspirin or clopidogrel or both before surgery. Before and after propensity score matching (PSM), the incidence of complications and mortality was compared between APT and non‐APT patients by using a logistic regression model. The sample remaining after PSM was 30 in the APT group and 80 in the non‐APT group. Results: The sample remaining after matching was 30 in the APT group and 80 in the non‐APT group. We found 10 cases with percutaneous coronary intervention in the APT group (33.3%). The APT group received more volume of packed red blood cells, 8.4 ± 6.05 units; plasma, 401.67 ± 727 ml, and platelet transfusion (14.07 ± 8.92 units). The drainage volume was much more in the APT group (5009.37 ± 2131.44 ml, p =.004). Mortality was higher in APT group (26% vs. 10%, p =.027). The preoperative APT was an independent predictor of mortality (odds ratio: 6.808, 95% confidence interval: 1.554–29.828, p =.011). Conclusion: APT before ATAAD repair was associated with more transfusions and higher early mortality. The timing of surgery should be carefully considered based on the patient's status and the surgeon's experience. Highlights: Whether preoperative antiplatelet therapy will affect the survival of patients with acute type A aortic dissection is still controversial.We conducted a retrospective analysis from the largest Chinese database.We provide new evidence to address this problem. [ABSTRACT FROM AUTHOR]

Published
2022
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90. Association between platelet counts and morbidity and mortality after endovascular repair for type B aortic dissection.

Author

Xie, Enmin, Liu, Jitao, Liu, Yuanhui, Liu, Yuan, Xue, Ling, Fan, Ruixin, Xie, Nianjin, Ding, Huanyu, Hu, Binquan, Chen, Lyufan, Yang, Xinyue, Yang, Fan, and Luo, JianFang

Subjects
AORTIC dissection, ENDOVASCULAR surgery, PLATELET count, LOGISTIC regression analysis, MESENTERIC ischemia, ACUTE kidney failure, INTENSIVE care units
Abstract

This study aimed to assess the association of postoperative platelet counts with early and late outcomes after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD). We retrospectively evaluated 892 patients with TBAD who underwent TEVAR from a prospectively maintained database. Postoperative nadir platelet counts were evaluated as a continuous variable, and a categorical variable (thrombocytopenia), which was defined as platelet count≤ the lowest 10% percentile (108 × 109/l). Multivariable logistic regression analyses were conducted to assess the impact of postoperative thrombocytopenia on early outcomes, and multivariable cox regression analyses on long-term mortality. Patients with postoperative thrombocytopenia experienced significantly higher rates of postoperative mortality, prolonged intensive care unit stay, death, stroke, limb ischemia, mesenteric ischemia, acute kidney injury (AKI), and puncture-related hematoma (P<.05 for each), but similar rates of immediate type I endoleak and spinal cord ischemia. Multivariable logistic analyses showed that postoperative thrombocytopenia was independently associated with postoperative stroke, limb ischemia, and AKI. Similar results were observed when postoperative nadir platelet count was modeled as a continuous predictor (P<.05 for each). By multivariable Cox analyses, postoperative thrombocytopenia was an independent predictor for long-term all-cause mortality (hazard ratio 2.72, 95% CI, 1.72–4.29, P<.001). For every 30 × 109/L decrease in postoperative platelet count, the risk of long-term all-cause mortality increased by 15% (HR 1.15; 95% CI 1.07–1.25; P<.001). Therefore, postoperative thrombocytopenia might be a useful tool for risk stratification after TEVAR. [ABSTRACT FROM AUTHOR]

Published
2022
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99. Outcomes Of Chimney Technique For Aortic Arch Diseases: A Single-Center Experience With 226 Cases

Author

Huang,Wenhui, Ding,Huanyu, Jiang,Minchun, Liu,Yuan, Huang,Cheng, Yang,Xinyue, Fan,Ruixin, Luo,Jianfang, Jiang,Zhisheng, Huang,Wenhui, Ding,Huanyu, Jiang,Minchun, Liu,Yuan, Huang,Cheng, Yang,Xinyue, Fan,Ruixin, Luo,Jianfang, and Jiang,Zhisheng

Abstract

Wenhui Huang,1,2,* Huanyu Ding,2,* Minchun Jiang,3,* Yuan Liu,2 Cheng Huang,2 Xinyue Yang,2,4,5 Ruixin Fan,6 Jianfang Luo,2,4,5 Zhisheng Jiang1 1Institute of Cardiovascular Disease and Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of China; 2Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China; 3School of Biomedical Sciences, The Chinese University of Hong Kong, Sha Tin, Hong Kong, People’s Republic of China; 4Guangdong Provincial People’s Hospital affiliated to South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 5School of Medicine, South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 6Department of Cardiovascular Surgery, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhisheng JiangInstitute of Cardiovascular Disease and Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, People’s Republic of ChinaEmail drzhishengjiang@126.comPurpose: The goal of present study is to document our single-center experience with chimney technique for aortic arch diseases.Patients and methods: From August 2012 to October 2017, 226 patients (mean age 54±12 years; 197 men) with aortic arch diseases underwent thoracic endovascular aortic repair combined w

Published
2019

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