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1,488 results on '"Esteban, Miguel A"'

65. Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network

Author

Du, Zhonghua, Wen, Xue, Wang, Yichen, Jia, Lin, Zhang, Shilin, Liu, Yudi, Zhou, Lei, Li, Hui, Yang, Wang, Wang, Cong, Chen, Jingcheng, Hao, Yajing, Salgado Figueroa, Daniela, Chen, Huiling, Li, Dan, Chen, Naifei, Celik, Ilkay, Zhu, Yanbo, Yan, Zi, Fu, Changhao, Liu, Shanshan, Jiao, Benzheng, Wang, Zhuo, Zhang, Hui, Gülsoy, Günhan, Luo, Jianjun, Qin, Baoming, Gao, Sujun, Kapranov, Philipp, Esteban, Miguel A., Zhang, Songling, Li, Wei, Ay, Ferhat, Chen, Runsheng, Hoffman, Andrew R., Cui, Jiuwei, and Hu, Ji-Fan

Published
2021
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66. Author Correction: Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network

Author

Du, Zhonghua, Wen, Xue, Wang, Yichen, Jia, Lin, Zhang, Shilin, Liu, Yudi, Zhou, Lei, Li, Hui, Yang, Wang, Wang, Cong, Chen, Jingcheng, Hao, Yajing, Salgado Figueroa, Daniela, Chen, Huiling, Li, Dan, Chen, Naifei, Celik, Ilkay, Zhu, Yanbo, Yan, Zi, Fu, Changhao, Liu, Shanshan, Jiao, Benzheng, Wang, Zhuo, Zhang, Hui, Gülsoy, Günhan, Luo, Jianjun, Qin, Baoming, Gao, Sujun, Kapranov, Philipp, Esteban, Miguel A., Zhang, Songling, Li, Wei, Ay, Ferhat, Chen, Runsheng, Hoffman, Andrew R., Cui, Jiuwei, and Hu, Ji-Fan

Published
2021
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83. Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells.

Author

Ji, Junfeng, Sharma, Vivek, Qi, Suxia, Guarch, Meritxell Espino, Zhao, Ping, Luo, Zhiwei, Fan, Wenxia, Wang, Yu, Mbabaali, Faridah, Neculai, Dante, Esteban, Miguel Angel, McPherson, John D, and Batada, Nizar N

Subjects
Cells, Cultured, Humans, DNA Damage, Genomic Instability, Reactive Oxygen Species, Transcription Factors, Antioxidants, Cell Survival, Induced Pluripotent Stem Cells, Cellular Reprogramming, Cells, Cultured, Biochemistry and Cell Biology, Clinical Sciences
Abstract

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) using oncogenic transcription factors. However, this method leads to genetic aberrations in iPSCs via unknown mechanisms, which may limit their clinical use. Here, we demonstrate that the supplementation of growth media with antioxidants reduces the genome instability of cells transduced with the reprogramming factors. Antioxidant supplementation did not affect transgene expression level or silencing kinetics. Importantly, iPSCs made with antioxidants had significantly fewer de novo copy number variations, but not fewer coding point mutations, than iPSCs made without antioxidants. Our results suggest that the quality and safety of human iPSCs might be enhanced by using antioxidants in the growth media during the generation and maintenance of iPSCs.

Published
2014

95. Climate change impacts on critical international transportation assets of Caribbean Small Island Developing States (SIDS): the case of Jamaica and Saint Lucia

Author

Monioudi, Isavela Ν., Asariotis, Regina, Becker, Austin, Bhat, Cassandra, Dowding-Gooden, Danielle, Esteban, Miguel, Feyen, Luc, Mentaschi, Lorenzo, Nikolaou, Antigoni, Nurse, Leonard, Phillips, Willard, Smith, David Α.Υ., Satoh, Mizushi, Trotz, Ulric O’Donnell, Velegrakis, Adonis F., Voukouvalas, Evangelos, Vousdoukas, Michalis I., and Witkop, Robert

Published
2018
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98. Sustentabilidad de la explotación de agua subterránea en la Cuenca Guanchín–Sañogasta, Chilecito, La Rioja

Author

Roberto Esteban Miguel and Joaquín Víctor González Ribot

Subjects
Pharmacology (medical)
Abstract

En la cuenca de Guanchín–Sañogasta se ha desarrollado desde el año 2014 un importante avance de la producción agrícola que utiliza de manera exclusiva agua subterránea para riego. Debido a que la descarga de la cuenca se concentra en el manantial “El bosquecillo” y en dos galerías filtrantes que abastecen de agua potable y riego a la localidad de Nonogasta surge el interrogante sobre la sustentabilidad del sistema. El objetivo es analizar la sostenibilidad de la explotación de la cuenca Guanchín–Sañogasta a partir de las potenciales implicancias en el medio físico natural (hidrológico-hidrogeológico). Se efectuó el análisis de datos de precipitación y estimación de recarga, descarga de la cuenca y su relación con la recarga, variación en la piezometría y estimación de la explotación de agua subterránea. Los resultados indican que un 60 % de la recarga se extrae para riego con descenso en la piezometría y disminución progresiva del caudal del manantial “El bosquecillo”. No obstante, los pozos actualmente construidos tienen la capacidad de extraer caudales muy por encima de los valores de recarga de la cuenca. Por lo tanto, la sustentabilidad del agua subterránea se encuentra afectada negativamente ante las consecuencias de la explotación intensiva. Es fundamental continuar con el registro de datos meteorológicos, hidrológicos e hidrogeológicos para fortalecer la hipótesis de que las alteraciones advertidas se deben principalmente a la extracción de agua subterránea y en menor medida a un proceso de variabilidad en las precipitaciones. Abstract In the Guanchín-Sañogasta basin, an important advance in agricultural production has been made since 2013 that exclusively uses groundwater for irrigation. Because the discharge from the basin is concentrated in the “El Bosquecillo” spring and in two filtering galleries that supply drinking water and irrigation in Nonogasta town, the question arises about the sustainability of the system. The objective of this study is to analyze the sustainability of the exploitation of the Guanchín-Sañogasta basin for the potential implications in the natural physical environment (hydrological-hydrogeological). We carried out data analysis of precipitation and estimation of recharge, basin discharge, and its relationship with recharge, variation in piezometry and estimation of groundwater exploitation. The results indicate that 60% of the recharge is extracted for irrigation with a decrease in piezometry and a progressive decrease in the flow of "El bosquecillo" spring. However, the existing wells are able to extract a groundwater volume above the recharge values. Therefore, the sustainability of groundwater is negatively affected by the consequences of the intensive exploitation. Thus, the collection of meteorological, hydrological, and hydrogeological data is essential to strengthen the hypothesis that the observed alterations are mainly due to the extraction of groundwater and to a lesser extent to a process of variability in rainfall.

Published
2022

99. Sorghum halepense (Zacate Johnson) as a potential natural corrosion inhibitor

Author

Pablo Javier Maldonado-Rivas, Esteban Miguel García-Ochoa, Francisco Eduardo Corvo-Pérez, and Manuel Jesús Chan-Bacab

Subjects
Marketing, Economics and Econometrics, General Chemical Engineering, General Materials Science
Abstract

Corrosion inhibitors can trigger health and/or environmental problems due to their toxicity. For this reason, it has been suggested to use plant extracts as natural corrosion inhibitors, because they represent a rich source of chemical compounds, they are non-toxic, biodegradable and abundant in nature. Sorghum halepense is a herbaceous weed, commonly known as johnson grass, belongs to the family gramíneae or poaceae, the choice of this plant is due to its zero cost and easy availability. In this systematic review, were used keywords such as Sorghum halepense johnson grass, phytochemistry, phytotherapy, phytoremediation, antidiabetic, antioxidant, cytotoxicity, antifungal, antimicrobial, anticancer, biological activity, medical activity, allelochemicals, among others. To do this, were used databases such as Scielo, Dialnet, Redalyc, Google Scholar, DOAJ, Wiley online library, BioOne, EBSCOHost, Knovel, ScienceDirect, SpringerLink y VirtualPro. Previous studies on this weed have reported its therapeutic potential against cancer, diabetes, prostatitis, hepatoprotective activity, antioxidant, antimicrobial, antifungal, as well as abortifacient and placental delivery in veterinary medicine. In view of the numerous organic molecules present in this plant, this study proposes Sorghum halepense as a potential natural corrosion inhibitor.

Published
2022

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