1,946 results on '"Erba P"'
Search Results
52. PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL)
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Prakken, Niek H. J., Besson, Florent L., Borra, Ronald J. H., Büther, Florian, Buechel, Ronny R., Catana, Ciprian, Chiti, Arturo, Dierckx, Rudi A. J. O., Dweck, Marc R., Erba, Paola A., Glaudemans, Andor W. J. M., Gormsen, Lars C., Hristova, Ivalina, Koole, Michel, Kwee, Thomas C., Mottaghy, Felix M., Polycarpou, Irene, Prokop, Mathias, Stegger, Lars, Tsoumpas, Charalampos, and Slart, Riemer H. J. A.
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- 2023
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53. Le mediche antiche
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Giancarla Erba
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prêtresses ,druides ,magie ,phytothérapie ,sage-femmes ,femmes gallo-romaines ,Language and Literature ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Abstract
Le lien entre la femme et la médecine est aussi ancien que la nuit des temps : dès la préhistoire, l’une des tâches des femmes était de cultiver les herbes qu’elles considéraient comme utiles pour la guérison des malades. Restant sur place pendant que les hommes chassaient, elles veillaient à la santé de leur clan : soigner sa famille et sa communauté fait partie de la fonction de la femme. Le domaine réservé à la plupart des soignantes était celui des soins dits féminins, la gynécologie et l’obstétrique, même si plusieurs d’entre elles, depuis l’Antiquité, ont réussi à se faire un nom en tant que médecin polyvalent. Dans ce travail, je relate la situation dans les sociétés grecque, romaine et celtique de la Gaule.
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- 2023
54. Characterization and nutritional valorization of agricultural waste corncobs from Italian maize landraces through the growth of medicinal mushrooms
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G. Castorina, C. Cappa, N. Negrini, F. Criscuoli, M. C. Casiraghi, A. Marti, M. Rollini, G. Consonni, and D. Erba
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Medicine ,Science - Abstract
Abstract The research investigates the potential use of maize cobs (or corncobs) from five genotypes, including the B73 inbred line and four locally cultivated landraces from Northern Italy, as substrate for implementing Solid State fermentation processes with four Medicinal Mushrooms (MMs). The corncobs were characterized based on their proximate composition, lignin, phenolics content (both free and bound), and total antioxidant capacity. Among the MMs tested, Pleurotus ostreatus and Ganoderma annularis demonstrated the most robust performance. Their growth was parametrized using Image Analysis technique, and chemical composition of culture samples was characterized compared to that of corncobs alone. In all culture samples, the growth of MMs led to a significant reduction (averaging 40%) in the total phenolics contents compared to that measured in corncobs alone. However, the high content of free phenolics in the cobs negatively impacted the growth of P. ostreatus. The final MM-corncob matrix exhibited reduced levels of free sugars and starch (≤ 2.2% DW, as a sum) and increased levels of proteins (up to 5.9% DW) and soluble dietary fiber (up to 5.0% DW), with a notable trend toward higher levels of β-glucan compared to corncobs alone. This research paves the way for the use of this matrix as an active ingredient to enhance the nutritional value of food preparations.
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- 2023
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55. Ultraviolet Spectropolarimetry With Polstar: Hot Star Magnetospheres
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Shultz, M. E., Casini, R., Cheung, M. C. M., David-Uraz, A., Alemán, T. del Pino, Erba, C., Folsom, C. P., Gayley, K., Ignace, R., Keszthelyi, Z., Kochukhov, O., Nazé, Y., Neiner, C., Oksala, M., Petit, V., Scowen, P. A., Sudnik, N., ud-Doula, A., Vink, J. S., and Wade, G. A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Polstar is a proposed NASA MIDEX space telescope that will provide high-resolution, simultaneous full-Stokes spectropolarimetry in the far ultraviolet, together with low-resolution linear polarimetry in the near ultraviolet. In this white paper, we describe the unprecedented capabilities this observatory would offer in order to obtain unique information on the magnetic and plasma properties of the magnetospheres of hot stars. This would enable a test of the fundamental hypothesis that magnetospheres should act to rapidly drain angular momentum, thereby spinning the star down, whilst simultaneously reducing the net mass-loss rate. Both effects are expected to lead to dramatic differences in the evolution of magnetic vs. non-magnetic stars., Comment: White paper, 40 pages
- Published
- 2021
56. Disparities in trial enrollment and outcomes of Hispanic adolescent and young adult acute lymphoblastic leukemia
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Muffly, Lori, Yin, Jun, Jacobson, Sawyer, Wall, Anna, Quiroz, Elisa, Advani, Anjali S, Luger, Selina M, Tallman, Martin S, Litzow, Mark R, Foster, Matthew C, Erba, Harry P, Appelbaum, Frederick R, Larson, Richard A, Keegan, Theresa HM, and Stock, Wendy
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Clinical Research ,Rare Diseases ,Pediatric Cancer ,Clinical Trials and Supportive Activities ,Cancer ,Pediatric ,Hematology ,Adolescent ,Clinical Trials as Topic ,Healthcare Disparities ,Hispanic or Latino ,Humans ,Incidence ,Patient Participation ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Registries ,United States ,Young Adult - Abstract
In this secondary analysis of Hispanic adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated on Cancer and Leukemia Group B (CALGB) 10403, we evaluated outcomes and geographic enrollment patterns relative to US population data. We used demographic, clinical, and survival data on AYAs enrolled on CALGB 10403 (N = 295, 2007-2012). Surveillance, Epidemiology, and End Results registries provided overall survival (OS) for US AYA ALL by ethnicity/race. North American Association of Cancer Registries provided AYA ALL incidence overall and proportion among Hispanics by US state. Of AYAs enrolled on CALGB 10403, 263 (89%) reported ethnicity/race: 45 (17%) Hispanic, 172 (65%) non-Hispanic White (NHW), 25 (10%) non-Hispanic Black (NHB), and 21 (8%) other. Compared with NHWs, Hispanic and NHB patients had lower household income, and Hispanic patients were more likely to harbor high-risk CRLF2 aberrations. Relative to US estimates, where Hispanic patients represented 46% of newly diagnosed AYA ALL patients and experienced inferior OS compared with NHW (P < .001), Hispanic AYAs on CALGB 10403 did as well as NHW patients (3 year OS, 75% vs 74%; P = NS). Hispanic patients also had higher rates of protocol completion (P = .05). Enrollments on CALGB 10403 differed relative to the distribution of Hispanic AYA ALL in the United States: enrollment was highest in the Midwest; t and only 15% of enrollees were from states with a high proportion of Hispanic AYA ALL patients. In summary, Hispanic patients treated on CALGB 10403 did as well as NHWs and better than population estimates. Geographical misalignment between trial sites and disease epidemiology may partially explain the lower-than-expected enrollment of Hispanic AYA ALL patients.
- Published
- 2022
57. Characterization and nutritional valorization of agricultural waste corncobs from Italian maize landraces through the growth of medicinal mushrooms
- Author
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Castorina, G., Cappa, C., Negrini, N., Criscuoli, F., Casiraghi, M. C., Marti, A., Rollini, M., Consonni, G., and Erba, D.
- Published
- 2023
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58. A dual-tracer approach using [11C]CH and [18F]FDG in HCC clinical decision making
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Veenstra, Emile B., Ruiter, Simeon J. S., de Haas, Robbert J., de Jong, Koert P., Erba, Paola A., Dierckx, Rudi A. J. O., and Noordzij, Walter
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- 2023
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59. Systemic immune response in young and elderly patients after traumatic brain injury
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Magatti, Marta, Pischiutta, Francesca, Ortolano, Fabrizio, Pasotti, Anna, Caruso, Enrico, Cargnoni, Anna, Papait, Andrea, Capuzzi, Franco, Zoerle, Tommaso, Carbonara, Marco, Stocchetti, Nino, Borsa, Stefano, Locatelli, Marco, Erba, Elisa, Prati, Daniele, Silini, Antonietta R, Zanier, Elisa R, and Parolini, Ornella
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- 2023
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60. Switch from a ritonavir to a cobicistat containing antiretroviral regimen and impact on tacrolimus levels in a kidney transplant recipient
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Erba, Andrea, Marzolini, Catia, Rentsch, Katharina, Stoeckle, Marcel, Battegay, Manuel, Mayr, Michael, and Weisser, Maja
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- 2023
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61. Verification of prognostic expression biomarkers is improved by examining enriched leukemic blasts rather than mononuclear cells from acute myeloid leukemia patients
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Pogosova-Agadjanyan, Era L., Hua, Xing, Othus, Megan, Appelbaum, Frederick R., Chauncey, Thomas R., Erba, Harry P., Fitzgibbon, Matthew P., Jenkins, Isaac C., Fang, Min, Lee, Stanley C., Moseley, Anna, Naru, Jasmine, Radich, Jerald P., Smith, Jenny L., Willborg, Brooke E., Willman, Cheryl L., Wu, Feinan, Meshinchi, Soheil, and Stirewalt, Derek L.
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- 2023
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62. Dietary intake and adherence to the Mediterranean diet in semi-professional female soccer players: a cross-sectional study
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Alessandro Modena, Maria Cristina Casiraghi, and Daniela Erba
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energy intake ,nutrient intake ,Mediterranean diet adherence ,soccer ,female players ,Nutrition. Foods and food supply ,TX341-641 - Abstract
BackgroundAdequate energy and nutrient intakes in athletes contribute to optimal performance and recovery, decrease the risk of injury, and help preserve athletes’ health. The Mediterranean diet (MD) is considered suitable for covering the nutritional needs of athletes, while contributing to improve eating habits. The aim of the present study was to investigate the energy and nutrient intakes of semi-professional female soccer players and their adherence to the MD, during the competitive season.MethodsA cross-sectional observational study was conducted on twenty-three female soccer players, who were invited to fill in a 3-day food diary twice, one month apart, to assess their energy and nutrient intakes and a validated questionnaire (MEDI-LITE) to evaluate their adherence to MD. Exercise energy expenditure during three training and match-play days was monitored by GPS.ResultsOn average, the participants consumed 1,981 kcal/day, with 44% of their energy deriving from carbohydrates, 21% from protein, and 34% from fat; the mean MD adherence score was 10.1 ± 1.8, corresponding to a good MD adherence. A substantial percentage of athletes were at risk of insufficient nutrient intakes for vitamin D (100%), iodine (87%), potassium (87%), vitamin E (39%), iron and zinc (17 and 30%, respectively).ConclusionThe evaluation of the dietary intake in female soccer players showed energy deficiency in relation to training level, mainly due to the insufficient intake of carbohydrates, and micronutrient deficiencies. The technical staff should promote adequate consumption of starchy foods in female athletes and emphasize the importance of a proper distribution of energy intake among different eating occasions, including snacks. Periodic monitoring of the nutritional status of micronutrients (vitamin D and some minerals) could help reduce deficiency risk. Over all, nutrition education to improve eating habits of athletes seems worthy of attention, in order to preserve athletes’ health and performance.
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- 2024
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63. Utilization of a Meningitis/Encephalitis PCR panel at the University Hospital Basel – a retrospective study to develop a diagnostic decision rule
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Andrea Erba, Fabian C. Franzeck, Vladimira Hinic, Adrian Egli, and Michael Osthoff
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Meningitis/Encephalitis PCR panel ,diagnostic stewardship ,decision rule ,syndromic panel ,neurological infection ,Medicine (General) ,R5-920 - Abstract
BackgroundThe Biofire® FilmArray® Meningitis/Encephalitis (ME) PCR panel covers 14 viral, bacterial, and fungal pathogens and has been implemented in many institutions worldwide. Post-marketing studies indicate a reduced sensitivity and overutilization underscoring the need for a more targeted usage. The aim of our study is to describe the utilization of the ME panel and to develop a diagnostic-stewardship based decision rule.MaterialsAdult patients, who underwent CSF analysis with the ME panel between August 2016 and June 2021 at the University Hospital Basel, were included. Demographic, clinical, microbiological, and laboratory data were extracted from the electronic health record. Factors associated with a positive ME panel result were identified, and a decision rule was developed to potentially optimize the diagnostic yield and reduce the number of unnecessary tests.Results1,236 adult patients received at least one panel in the observed period, of whom 106 panels tested positive (8.6%). The most frequently observed pathogens were Varicella Zoster Virus (VZV, 27%), Streptococcus pneumoniae (19%), Enterovirus (16%), Herpes simplex Virus 1/2 (16%), and Human Herpesvirus 6 (HHV-6, 13%). Fever, vomiting, headache, and photophobia were more frequently present in test positive patients as were significantly higher CSF leukocytes and protein concentrations. When simulating a decision rule based on CSF leukocytes and protein concentration, only 35% of all patients would have qualified for a ME panel tests, thereby increasing the positivity rate to 22.7%. 10 of 106 positive ME panels would have been missed, only involving HHV-6 and VZV (6 and 4 cases, respectively). As these subjects were either severely immunocompromised or had clinical features of shingles we propose extending the testing algorithm by including those criteria.ConclusionThe ME panel positivity rate at our institution was similar as previously published. Our results highlight the need for diagnostic-stewardship interventions when utilizing this assay by implementing a stepwise approach based on a limited number of clinical and laboratory features. This decision rule may improve the pretest probability of a positive test result, increase the quality of test utilization, and reduce costs.
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- 2024
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64. Detecting the Zeeman effect in Massive Star Magnetospheres in the UV
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Erba, C., Petit, V., Gayley, K., Ignace, R., ud-Doula, A., and Wade, G. A.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Approximately 7% of massive stars host stable surface magnetic fields that are strong enough to alter stellar evolution through their effect on the stellar wind. It is therefore crucial to characterize the strength and structure of these large-scale fields in order to quantify their influence on massive star evolution. This is traditionally done by measuring the circular polarization caused by Zeeman splitting in optical photospheric lines, but we investigate here the possibility of detecting Stokes $V$ signatures in the wind-sensitive resonance lines formed in magnetically confined winds in the high opacity ultraviolet (UV) domain. This unique diagnostic would be accessible to high-sensitivity spaceborne UV spectropolarimeters such as POLSTAR., Comment: Proceedings article from IAUS 360 -- Astronomical Polarimetry 2020: New Era of Multiwavelength Polarimetry. 2 pages, 1 figure
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- 2021
65. Ultraviolet Line Profiles of Slowly Rotating Massive Star Winds Using the 'Analytic Dynamical Magnetosphere' Formalism
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Erba, C., David-Uraz, A., Petit, V., Hennicker, L., Fletcher, C., Fullerton, A. W., Nazé, Y., Sundqvist, J., and ud-Doula, A.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Recent large-scale spectropolarimetric surveys have established that a small but significant percentage of massive stars host stable, surface dipolar magnetic fields with strengths on the order of kG. These fields channel the dense, radiatively driven stellar wind into circumstellar magnetospheres, whose density and velocity structure can be probed using ultraviolet (UV) spectroscopy of wind-sensitive resonance lines. Coupled with appropriate magnetosphere models, UV spectroscopy provides a valuable way to investigate the wind-field interaction, and can yield quantitative estimates of the wind parameters of magnetic massive stars. We report a systematic investigation of the formation of UV resonance lines in slowly rotating magnetic massive stars with dynamical magnetospheres. We pair the Analytic Dynamical Magnetosphere (ADM) formalism with a simplified radiative transfer technique to produce synthetic UV line profiles. Using a grid of models, we examine the effect of magnetosphere size, the line strength parameter, and the cooling parameter on the structure and modulation of the line profile. We find that magnetic massive stars uniquely exhibit redshifted absorption at most viewing angles and magnetosphere sizes, and that significant changes to the shape and variation of the line profile with varying line strengths can be explained by examining the individual wind components described in the ADM formalism. Finally, we show that the cooling parameter has a negligible effect on the line profiles., Comment: 16 pages, 15 figures, accepted to MNRAS
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- 2021
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66. Confirmation of xi^1 CMa's ultra-slow rotation: magnetic polarity reversal and a dramatic change in magnetospheric UV emission lines
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Erba, C., Shultz, M. E., Petit, V., Fullerton, A. W., Henrichs, H. F., Kochukhov, O., Rivinius, T., and Wade, G. A.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
The magnetic beta Cep pulsator xi^1 CMa has the longest rotational period of any known magnetic B-type star. It is also the only magnetic B-type star with magnetospheric emission that is known to be modulated by both rotation and pulsation. We report here the first unambiguous detection of a negative longitudinal magnetic field in xi^1 CMa (
=-87 +/- 2 G in 2019 and =-207 +/- 3 G in 2020), as well as the results of ongoing monitoring of the star's Halpha variability. We examine evidence for deviation from a purely dipolar topology. We also report a new HST UV spectrum of xi^1 CMa obtained near magnetic null that is consistent with an equatorial view of the magnetosphere, as evidenced by its similarity to the UV spectrum of beta Cep obtained near maximum emission. The new UV spectrum of xi^1 CMa provides additional evidence for the extremely long rotation period of this star via comparison to archival data., Comment: 13 pages, Accepted 2021 May 14 to Monthly Notices of the Royal Astronomical Society 2021 - Published
- 2021
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67. Radioligand therapies in cancer: mapping the educational landscape in Europe
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Bugani, Valentina, Battistelli, Luca, Sansovini, Maddalena, Monti, Manuela, Paganelli, Giovanni, Gich, Ignasi, Flotats, Albert, Erba, Paola Anna, Blay, Jean-Yves, la Fougère, Christian, Van Poppel, Hendrik, Charalambous, Andreas, Herrmann, Ken, Giordano, Alessandro, Györke, Tamás, Deroose, Christophe, Matteucci, Federica, and Carrió, Ignasi
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- 2023
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68. A Global Building Occupant Behavior Database
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Dong, Bing, Liu, Yapan, Mu, Wei, Jiang, Zixin, Pandey, Pratik, Hong, Tianzhen, Olesen, Bjarne, Lawrence, Thomas, O’Neil, Zheng, Andrews, Clinton, Azar, Elie, Bandurski, Karol, Bardhan, Ronita, Bavaresco, Mateus, Berger, Christiane, Burry, Jane, Carlucci, Salvatore, Chvatal, Karin, De Simone, Marilena, Erba, Silvia, Gao, Nan, Graham, Lindsay T, Grassi, Camila, Jain, Rishee, Kumar, Sanjay, Kjærgaard, Mikkel, Korsavi, Sepideh, Langevin, Jared, Li, Zhengrong, Lipczynska, Aleksandra, Mahdavi, Ardeshir, Malik, Jeetika, Marschall, Max, Nagy, Zoltan, Neves, Leticia, O’Brien, William, Pan, Song, Park, June Young, Pigliautile, Ilaria, Piselli, Cristina, Pisello, Anna Laura, Rafsanjani, Hamed Nabizadeh, Rupp, Ricardo Forgiarini, Salim, Flora, Schiavon, Stefano, Schwee, Jens, Sonta, Andrew, Touchie, Marianne, Wagner, Andreas, Walsh, Sinead, Wang, Zhe, Webber, David M, Yan, Da, Zangheri, Paolo, Zhang, Jingsi, Zhou, Xiang, and Zhou, Xin
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Built Environment and Design ,Information and Computing Sciences ,Architecture ,Building - Abstract
This paper introduces a database of 34 field-measured building occupant behavior datasets collected from 15 countries and 39 institutions across 10 climatic zones covering various building types in both commercial and residential sectors. This is a comprehensive global database about building occupant behavior. The database includes occupancy patterns (i.e., presence and people count) and occupant behaviors (i.e., interactions with devices, equipment, and technical systems in buildings). Brick schema models were developed to represent sensor and room metadata information. The database is publicly available, and a website was created for the public to access, query, and download specific datasets or the whole database interactively. The database can help to advance the knowledge and understanding of realistic occupancy patterns and human-building interactions with building systems (e.g., light switching, set-point changes on thermostats, fans on/off, etc.) and envelopes (e.g., window opening/closing). With these more realistic inputs of occupants' schedules and their interactions with buildings and systems, building designers, energy modelers, and consultants can improve the accuracy of building energy simulation and building load forecasting.
- Published
- 2022
69. Security Analysis of Vendor Implementations of the OPC UA Protocol for Industrial Control Systems
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Erba, Alessandro, Müller, Anne, and Tippenhauer, Nils Ole
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Computer Science - Cryptography and Security - Abstract
The OPC UA protocol is an upcoming de-facto standard for building Industry 4.0 processes in Europe, and one of the few industrial protocols that promises security features to prevent attackers from manipulating and damaging critical infrastructures. Despite the importance of the protocol, challenges in the adoption of OPC UA's security features by product vendors, libraries implementing the standard, and end-users were not investigated so far. In this work, we systematically investigate 48 publicly available artifacts consisting of products and libraries for OPC UA and show that 38 out of the 48 artifacts have one (or more) security issues. In particular, we show that 7 OPC UA artifacts do not support the security features of the protocol at all. In addition, 31 artifacts that partially feature OPC UA security rely on incomplete libraries and come with misleading instructions. Consequently, relying on those products and libraries will result in vulnerable implementations of OPC UA security features. To verify our analysis, we design, implement, and demonstrate attacks in which the attacker can steal credentials exchanged between victims, eavesdrop on process information, manipulate the physical process through sensor values and actuator commands, and prevent the detection of anomalies.
- Published
- 2021
70. The number of optimal matchings for Euclidean Assignment on the line
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Caracciolo, Sergio, Erba, Vittorio, and Sportiello, Andrea
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Mathematics - Probability ,Condensed Matter - Disordered Systems and Neural Networks ,Mathematics - Combinatorics - Abstract
We consider the Random Euclidean Assignment Problem in dimension $d=1$, with linear cost function. In this version of the problem, in general, there is a large degeneracy of the ground state, i.e. there are many different optimal matchings (say, $\sim \exp(S_N)$ at size $N$). We characterize all possible optimal matchings of a given instance of the problem, and we give a simple product formula for their number. Then, we study the probability distribution of $S_N$ (the zero-temperature entropy of the model), in the uniform random ensemble. We find that, for large $N$, $S_N \sim \frac{1}{2} N \log N + N s + \mathcal{O}\left( \log N \right)$, where $s$ is a random variable whose distribution $p(s)$ does not depend on $N$. We give expressions for the asymptotics of the moments of $p(s)$, both from a formulation as a Brownian process, and via singularity analysis of the generating functions associated to $S_N$. The latter approach provides a combinatorial framework that allows to compute an asymptotic expansion to arbitrary order in $1/N$ for the mean and the variance of
- Published
- 2021
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71. Self-induced glassy phase in multimodal cavity quantum electrodynamics
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Erba, Vittorio, Pastore, Mauro, and Rotondo, Pietro
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Disordered Systems and Neural Networks ,Quantum Physics - Abstract
We provide strong evidence that the effective spin-spin interaction in a multimodal confocal optical cavity gives rise to a self-induced glassy phase, which emerges exclusively from the peculiar euclidean correlations and is not related to the presence of disorder as in standard spin glasses. As recently shown, this spin-spin effective interaction is both non-local and non-translational invariant, and randomness in the atoms positions produces a spin glass phase. Here we consider the simplest feasible disorder-free setting where atoms form a one-dimensional regular chain and we study the thermodynamics of the resulting effective Ising model. We present extensive results showing that the system has a low-temperature glassy phase. Notably, for rational values of the only free adimensional parameter $\alpha=p/q$ of the interaction, the number of metastable states at low temperature grows exponentially with $q$ and the problem of finding the ground state rapidly becomes computationally intractable, suggesting that the system develops high energy barriers and ergodicity breaking occurs.
- Published
- 2021
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72. Leveraging User-Friendly Mobile Medical Devices to Facilitate Early Hospital Discharges in a Pediatric Setting: A Randomized Trial Study Protocol
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Gianvincenzo Zuccotti, Marta Marsilio, Laura Fiori, Paola Erba, Francesca Destro, Costantino Zamana, Laura Folgori, Anna Mandelli, Davide Braghieri, Chiara Guglielmetti, Martina Pisarra, Letizia Magnani, Gabriele Infante, Dario Dilillo, Valentina Fabiano, Patrizia Carlucci, Elena Zoia, Gloria Pelizzo, and Valeria Calcaterra
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user-friendly mobile ,medical devices ,early hospital discharges ,pediatrics ,children ,Pediatrics ,RJ1-570 - Abstract
Background: Mobile technology is increasingly prevalent in healthcare, serving various purposes, including remote health monitoring and patient self-management, which could prove beneficial to early hospital discharges. Aims: This study investigates the transitional care program experience facilitating early discharges in a pediatric setting through the use of an easy-to-use mobile medical device (TytoCare™, TytoCare Ltd., Natanya, Israel). Outcomes: This study aims to assess the effectiveness of telehomecare in achieving complete resolution of diseases without readmission, compare the length of stay between intervention and standard care groups, and gather user and professional experiences. Methods: A randomized open-label, controlled pilot study enrolled 102 children, randomly assigned to the telehomecare (TELE) group (n = 51, adopting early hospital discharge with continued home monitoring) or the standard-of-care (STAND) group (n = 51). Primary outcomes include complete disease resolution without readmission. Secondary objectives include recording a shorter length of stay in the intervention group. Surveys on user and professional experiences were conducted. A group of 51 children declining telemedicine services (NO-TELE) was also included. Results: In the TELE group, 100% of children achieved complete disease resolution without readmission, with a median duration of stay of 4 days, significantly shorter than the 7 days in the STAND group (p = 0.01). The telemedicine system demonstrated efficient performance and high satisfaction levels. The NO-TELE group showed no significant differences in demographics or digital technology competence. Perceived benefits of telemedicine included time and cost savings, reduced hospital stays, and technology utility and usability. Conclusions: This study demonstrates that user-friendly mobile medical devices effectively facilitate early hospital discharges in a pediatric setting. These devices serve as a bridge between home and hospital, optimizing care pathways.
- Published
- 2024
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73. No Need to Know Physics: Resilience of Process-based Model-free Anomaly Detection for Industrial Control Systems
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Erba, Alessandro and Tippenhauer, Nils Ole
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Computer Science - Cryptography and Security ,Computer Science - Machine Learning - Abstract
In recent years, a number of process-based anomaly detection schemes for Industrial Control Systems were proposed. In this work, we provide the first systematic analysis of such schemes, and introduce a taxonomy of properties that are verified by those detection systems. We then present a novel general framework to generate adversarial spoofing signals that violate physical properties of the system, and use the framework to analyze four anomaly detectors published at top security conferences. We find that three of those detectors are susceptible to a number of adversarial manipulations (e.g., spoofing with precomputed patterns), which we call Synthetic Sensor Spoofing and one is resilient against our attacks. We investigate the root of its resilience and demonstrate that it comes from the properties that we introduced. Our attacks reduce the Recall (True Positive Rate) of the attacked schemes making them not able to correctly detect anomalies. Thus, the vulnerabilities we discovered in the anomaly detectors show that (despite an original good detection performance), those detectors are not able to reliably learn physical properties of the system. Even attacks that prior work was expected to be resilient against (based on verified properties) were found to be successful. We argue that our findings demonstrate the need for both more complete attacks in datasets, and more critical analysis of process-based anomaly detectors. We plan to release our implementation as open-source, together with an extension of two public datasets with a set of Synthetic Sensor Spoofing attacks as generated by our framework., Comment: An updated version of the paper has been published at ACSAC'2022: Assessing Model-free Anomaly Detection in Industrial Control Systems Against Generic Concealment Attacks https://dl.acm.org/doi/10.1145/3564625.3564633
- Published
- 2020
74. Sex-based differences in nuclear medicine imaging and therapy
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Slart, Riemer H. J. A., de Geus-Oei, Lioe-Fee, Stevens, Jasper, Elsinga, Philip A., Ivashchenko, Oleksandra, and Erba, Paola A.
- Published
- 2023
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75. [111In]In-CP04 as a novel cholecystokinin-2 receptor ligand with theranostic potential in patients with progressive or metastatic medullary thyroid cancer: final results of a GRAN-T-MTC Phase I clinical trial
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Lezaic, Luka, Erba, Paola Anna, Decristoforo, Clemens, Zaletel, Katja, Mikolajczak, Renata, Maecke, Helmut, Maina, Theodosia, Konijnenberg, Mark, Kolenc, Petra, Trofimiuk-Müldner, Malgorzata, Przybylik-Mazurek, Elwira, Virgolini, Irene, de Jong, Marion, Fröberg, Alide C, Rangger, Christine, Di Santo, Gianpaolo, Skorkiewicz, Konrad, Garnuszek, Piotr, Solnica, Bogdan, Nock, Berthold A., Fedak, Danuta, Gaweda, Paulina, and Hubalewska-Dydejczyk, Alicja
- Published
- 2023
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76. Implementing a multi-cycle datapath with Liquid Marbles
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Sandro Erba, Luca Cavenaghi, and Claudio Zandron
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Medicine ,Science - Published
- 2024
77. Review on Desirable Microbial Phytases as a Poultry Feed Additive: Their Sources, Production, Enzymatic Evaluation, Market Size, and Regulation
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Olyad Erba Urgessa, Rufael Koyamo, Hunduma Dinka, Ketema Tefese, and Mesfin Tafesse Gemeda
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Microbiology ,QR1-502 - Abstract
Poultry’s digestive tract lacks hydrolytic phytase enzymes, which results in chelation of dietary minerals, vital amino acids, proteins, and carbohydrates, phytate-phosphate unavailability, and contamination of the environment due to phosphorus. Therefore, it is necessary to use exogenous microbial phytases as feed additive to chicken feed to catalyze the hydrolysis of dietary phytate. Potential sources of microbial isolates that produce desired phytases for chicken feed supplementation have been isolated from agricultural croplands. It is achievable to isolate phytase-producing bacteria isolates using both broth and agar phytase screening media. Potential substrates for submerged fermentation (SmF) for bacterial phytase production and solid-state fermentation (SSF) for fungal phytase production include rice and wheat bran. Following fermentation, saturated ammonium sulphate precipitation is typically used to partially purify microbial culture filtrate. The precipitate is then desalted. Measurements of the pH optimum and stability, temperature optimum and stability, metal ions stability, specificity and affinity to target substrate, proteolysis resistance, storage stability, and in vitro feed dephosphorylation are used to perform an enzymatic evaluation of phytase as an additive for poultry feed. The growth of the feed phytase market is primarily due to the expansion of chicken farms to meet the demand for meat and eggs from humans. The Food and Drug Administration in the USA and the European Food and Safety Authority are primarily in charge of putting rules pertaining to feed phytase use in chicken feed into effect. Conclusively, important components of the production of phytase additives for poultry feed include identifying a reliable source for potential microbe isolation, selecting an economical method of phytase production, thoroughly characterizing the biochemical properties of phytase, and comprehending the size and regulation of the current feed phytase market.
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- 2024
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78. Metaphoric language in the differential diagnosis of epilepsy and psychogenic non-epileptic seizures: Time to move forward
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Lina Urh, Daniele Piscitelli, Massimiliano Beghi, Silvia Diotti, Giuseppe Erba, Adriana Magaudda, Mikhail Zinchuk, Alla Guekht, and Cesare Maria Cornaggia
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Metaphors ,Psychogenic seizures ,Nonepileptic seizures ,Epileptic seizures ,Conversation analysis ,Neurology. Diseases of the nervous system ,RC346-429 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Conversation analysis (CA) to identify metaphoric language (ML) has been proposed as a tool for the differential diagnosis of epileptic (ES) and psychogenic nonepileptic seizures (PNES). However, the clinical relevance of metaphoric conceptualizations is not clearly defined. The current study aims to investigate the ML utilized by individuals with ES and PNES in a pulled multi-country sample. Two blinded researchers examined the transcripts and videos of 54 interviews of individuals (n = 29, Italy; n = 11, USA; n = 14, Russia) with ES and PNES, identifying the patient-seizure relationship representative of the patient's internal experience. The diagnoses were based on video-EEG. Metaphors were classified as “Space/place”, “External force”, “Voluntary action”, and “Other”. A total of 175 metaphors were identified. No differences between individuals with ES and PNES were found in metaphoric occurrence (χ2 (1, N = 54) = 0.07; p = 0.74). No differences were identified when comparing the types of metaphors utilized by participants with ES and those with PNES. Patients with PNES and ES did not demonstrate differences in terms of occurrence and categories in ML. Therefore, researchers and clinicians should carefully consider the use of metaphor conceptualizations for diagnostic purposes.
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- 2024
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79. The p-Airy distribution
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Caracciolo, Sergio, Erba, Vittorio, and Sportiello, Andrea
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Mathematics - Combinatorics ,Condensed Matter - Disordered Systems and Neural Networks ,Computer Science - Discrete Mathematics ,Mathematical Physics ,Mathematics - Probability - Abstract
In this manuscript we consider the set of Dyck paths equipped with the uniform measure, and we study the statistical properties of a deformation of the observable "area below the Dyck path" as the size $N$ of the path goes to infinity. The deformation under analysis is apparently new: while usually the area is constructed as the sum of the heights of the steps of the Dyck path, here we regard it as the sum of the lengths of the connected horizontal slices under the path, and we deform it by applying to the lengths of the slices a positive regular function $\omega(\ell)$ such that $\omega(\ell) \sim \ell^p$ for large argument. This shift of paradigm is motivated by applications to the Euclidean Random Assignment Problem in Random Combinatorial Optimization, and to Tree Hook Formulas in Algebraic Combinatorics. For $p \in \mathbb{R}^+ \smallsetminus \left\{ \frac{1}{2}\right\}$, we characterize the statistical properties of the deformed area as a function of the deformation function $\omega(\ell)$ by computing its integer moments, finding a generalization of a well-known recursion for the moments of the area-Airy distribution, due to Tak\'acs. Most of the properties of the distribution of the deformed area are \emph{universal}, meaning that they depend on the deformation parameter $p$, but not on the microscopic details of the function $\omega(\ell)$. We call \emph{$p$-Airy distribution} this family of universal distributions.
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- 2020
80. New observations of NGC 1624-2 reveal a complex magnetospheric structure and underlying surface magnetic geometry
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David-Uraz, A., Petit, V., Shultz, M. E., Fullerton, A. W., Erba, C., Keszthelyi, Z., Seadrow, S., and Wade, G. A.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
NGC 1624-2 is the most strongly magnetized O-type star known. Previous spectroscopic observations of this object in the ultraviolet provided evidence that it hosts a large and dense circumstellar magnetosphere. Follow-up observations obtained with the \textit{Hubble Space Telescope} not only confirm that previous inference, but also suggest that NGC 1624-2's magnetosphere has a complex structure. Furthermore, an expanded spectropolarimetric time series shows a potential departure from a dipolar magnetic field geometry, which could mean that the strongest field detected at the surface of an O-type star is also topologically complex. This result raises important questions regarding the origin and evolution of magnetic fields in massive stars., Comment: 12 pages, 3 figures, accepted for publication by MNRAS (2020 December 1)
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- 2020
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81. Classicality without local discriminability: decoupling entanglement and complementarity
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D'Ariano, Giacomo Mauro, Erba, Marco, and Perinotti, Paolo
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Quantum Physics - Abstract
An operational probabilistic theory where all systems are classical, and all pure states of composite systems are entangled, is constructed. The theory is endowed with a rule for composing an arbitrary number of systems, and with a nontrivial set of transformations. Hence, we demonstrate that the presence of entanglement is independent of the existence of incompatible measurements. We then study a variety of phenomena occurring in the theory -- some of them contradicting both Classical and Quantum Theories -- including: cloning, entanglement swapping, dense coding, additivity of classical capacities, non-monogamous entanglement, hypersignaling. We also prove the existence, in the theory, of a universal processor. The theory is causal and satisfies the no-restriction hypothesis. At the same time, it violates a number of information-theoretic principles enjoyed by Quantum Theory, most notably: local discriminability, purity of parallel composition of states, and purification. Moreover, we introduce an exhaustive procedure to construct generic operational probabilistic theories, and a sufficient set of conditions to verify their consistency. In addition, we prove a characterisation theorem for the parallel composition rules of arbitrary theories, and specialise it to the case of bilocal-tomographic theories. We conclude pointing out some open problems. In particular, on the basis of the fact that every separable state of the theory is a statistical mixture of entangled states, we formulate a no-go conjecture for the existence of a local-realistic ontological model., Comment: 24+7 pages, 2 figures, 1 table, plenty of diagrams; section "Conceptual Preview" added in v2; differently from the published version, a table of contents is herein present
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- 2020
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82. Statistical learning theory of structured data
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Pastore, Mauro, Rotondo, Pietro, Erba, Vittorio, and Gherardi, Marco
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
The traditional approach of statistical physics to supervised learning routinely assumes unrealistic generative models for the data: usually inputs are independent random variables, uncorrelated with their labels. Only recently, statistical physicists started to explore more complex forms of data, such as equally-labelled points lying on (possibly low dimensional) object manifolds. Here we provide a bridge between this recently-established research area and the framework of statistical learning theory, a branch of mathematics devoted to inference in machine learning. The overarching motivation is the inadequacy of the classic rigorous results in explaining the remarkable generalization properties of deep learning. We propose a way to integrate physical models of data into statistical learning theory, and address, with both combinatorial and statistical mechanics methods, the computation of the Vapnik-Chervonenkis entropy, which counts the number of different binary classifications compatible with the loss class. As a proof of concept, we focus on kernel machines and on two simple realizations of data structure introduced in recent physics literature: $k$-dimensional simplexes with prescribed geometric relations and spherical manifolds (equivalent to margin classification). Entropy, contrary to what happens for unstructured data, is nonmonotonic in the sample size, in contrast with the rigorous bounds. Moreover, data structure induces a novel transition beyond the storage capacity, which we advocate as a proxy of the nonmonotonicity, and ultimately a cue of low generalization error. The identification of a synaptic volume vanishing at the transition allows a quantification of the impact of data structure within replica theory, applicable in cases where combinatorial methods are not available, as we demonstrate for margin learning., Comment: 19 pages, 3 figures
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- 2020
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83. MOBSTER -- IV. Detection of a new magnetic B-type star from follow-up spectropolarimetric observations of photometrically selected candidates
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David-Uraz, A., Shultz, M. E., Petit, V., Bowman, D. M., Erba, C., Fine, R. A., Neiner, C., Pablo, H., Sikora, J., ud-Doula, A., and Wade, G. A.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
In this paper, we present results from the spectropolarimetric follow-up of photometrically selected candidate magnetic B stars from the MOBSTER project. Out of four observed targets, one (HD 38170) is found to host a detectable surface magnetic field, with a maximum longitudinal field measurement of 105$\pm$14 G. This star is chemically peculiar and classified as an $\alpha^2$ CVn variable. Its detection validates the use of TESS to perform a photometric selection of magnetic candidates. Furthermore, upper limits on the strength of a putative dipolar magnetic field are derived for the remaining three stars, and we report the discovery of a previously unknown spectroscopic binary system, HD 25709. Finally, we use our non-detections as case studies to further inform the criteria to be used for the selection of a larger sample of stars to be followed up using high-resolution spectropolarimetry., Comment: 9 pages, 6 figures, 4 tables, accepted by MNRAS (2021 March 23)
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- 2020
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84. Random geometric graphs in high dimension
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Erba, Vittorio, Ariosto, Sebastiano, Gherardi, Marco, and Rotondo, Pietro
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
Many machine learning algorithms used for dimensional reduction and manifold learning leverage on the computation of the nearest neighbours to each point of a dataset to perform their tasks. These proximity relations define a so-called geometric graph, where two nodes are linked if they are sufficiently close to each other. Random geometric graphs, where the positions of nodes are randomly generated in a subset of $\mathbb{R}^{d}$, offer a null model to study typical properties of datasets and of machine learning algorithms. Up to now, most of the literature focused on the characterization of low-dimensional random geometric graphs whereas typical datasets of interest in machine learning live in high-dimensional spaces ($d \gg 10^{2}$). In this work, we consider the infinite dimensions limit of hard and soft random geometric graphs and we show how to compute the average number of subgraphs of given finite size $k$, e.g. the average number of $k$-cliques. This analysis highlights that local observables display different behaviors depending on the chosen ensemble: soft random geometric graphs with continuous activation functions converge to the naive infinite dimensional limit provided by Erd\"os-R\'enyi graphs, whereas hard random geometric graphs can show systematic deviations from it. We present numerical evidence that our analytical insights, exact in infinite dimensions, provide a good approximation also for dimension $d\gtrsim10$.
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- 2020
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85. Quantitative Modeling of the UV Line Profiles of Magnetic Massive Stars
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Erba, Christiana, Petit, Veronique, David-Uraz, Alexandre, and Fullerton, Alex
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Recent spectropolarimetric surveys (MiMeS, BOB) have revealed that approximately 7% of massive stars host stable, surface dipolar magnetic fields with strengths on the order of kG. These fields channel the dense radiatively driven stellar wind into a circumstellar magnetosphere. Wind-sensitive UV spectral lines can probe the density and velocity structure of massive star magnetospheres, providing insight into wind-field interactions. To date, large-scale magnetohydrodynamic modeling of this phenomenon has been limited by the associated computational cost. Our analysis, using the Analytic Dynamical Magnetosphere model, solves this problem by applying a simple analytic prescription to efficiently calculate synthetic UV spectral lines. It can therefore be applied in the context of a larger parameter study to derive the wind properties for the population of known magnetic O stars. We also present the latest UV spectra of the magnetic O star NGC 1624-2 obtained with HST/COS, which test the limits of our models and suggest a particularly complex magnetospheric structure for this archetypal object., Comment: Stellar Magnetic Fields: A workshop in honor of the career and contributions of John Landstreet
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- 2019
86. Evolving pulsation of the slowly rotating magnetic $\beta$ Cep star $\xi^1$ CMa
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Wade, G. A., Pigulski, A., Begy, S., Shultz, M., Handler, G., Sikora, J., Neilson, H., Cugier, H., Erba, C., Moffat, A. F. J., Pablo, B., Popowicz, A., Weiss, W., and Zwintz, K.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Recent BRITE-Constellation space photometry of the slowly rotating, magnetic $\beta$ Cep pulsator $\xi^1$ CMa permits a new analysis of its pulsation properties. Analysis of the two-colour BRITE data reveals the well-known single pulsation period of $0.209$ d, along with its first and second harmonics. A similar analysis of SMEI and TESS observations yields compatible results, with the higher precision TESS observations also revealing several low-amplitude modes with frequencies below 5 d$^{-1}$; some of these are likely $g$ modes. The phase lag between photometric and radial velocity maxima - equal to 0.334 cycles - is significantly larger than the typical value of $1/4$ observed in other large-amplitude $\beta$ Cep stars. The phase lag, as well as the strong dependence of phase of maximum light on wavelength, can be reconciled with seismic models only if the dominant mode is the fundamental radial mode. We employ all published photometric and radial velocity measurements, spanning over a century, to evaluate the stability of the pulsation period. The $O-C$ diagram exhibits a clear parabolic shape consistent with a mean rate of period change $\dot P=0.34\pm 0.02$ s/cen. The residuals from the best-fit parabola exhibit scatter that is substantially larger than the uncertainties. In particular, dense sampling obtained during the past $\sim$20 years suggests more complex and rapid period variations. Those data cannot be coherently phased with the mean rate of period change, and instead require $\dot P\sim0.9$ s/cen. We examine the potential contributions of binarity, stellar evolution, and stellar rotation and magnetism to understand the apparent period evolution., Comment: 14 pages, accepted by MNRAS
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- 2019
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87. MOBSTER: Establishing a Picture of Magnetic Massive Stars as a Population
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David-Uraz, Alexandre, Neiner, Coralie, Sikora, James, Barron, James, Bowman, Dominic M., Cerrahoğlu, Pınar, Cohen, David H., Erba, Christiana, Kobzar, Oleksandr, Kochukhov, Oleg, Petit, Véronique, Shultz, Matthew E., ud-Doula, Asif, Wade, Gregg A., and Collaboration, the MOBSTER
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Magnetic massive and intermediate-mass stars constitute a separate population whose properties are still not fully understood. Increasing the sample of known objects of this type would help answer fundamental questions regarding the origins and characteristics of their magnetic fields. The MOBSTER Collaboration seeks to identify candidate magnetic A, B and O stars and explore the incidence and origins of photometric rotational modulation using high-precision photometry from the Transiting Exoplanet Survey Satellite (\textit{TESS}) mission. In this contribution, we present an overview of our methods and planned targeted spectropolarimetric follow-up surveys., Comment: 7 pages, 1 figure, Conference proceedings: "Stellar Magnetic Fields - A workshop in honour of the career and contributions of John Landstreet", London, Canada, 2019 (to be published in the Proceedings of the Polish Astronomical Society)
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- 2019
88. Magnetic OB[A] Stars with TESS: probing their Evolutionary and Rotational properties -- The MOBSTER Collaboration
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David-Uraz, A., Neiner, C., Sikora, J., Barron, J., Bowman, D. M., Cerrahoğlu, P., Cohen, D. H., Erba, C., Khalack, V., Kobzar, O., Kochukhov, O., Pablo, H., Petit, V., Shultz, M. E., ud-Doula, A., Wade, G. A., and Collaboration, the MOBSTER
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
In this contribution, we present the MOBSTER Collaboration, a large community effort to leverage high-precision photometry from the Transiting Exoplanet Survey Satellite (\textit{TESS}) in order to characterize the variability of magnetic massive and intermediate-mass stars. These data can be used to probe the varying column density of magnetospheric plasma along the line of sight for OB stars, thus improving our understanding of the interaction between surface magnetic fields and massive star winds. They can also be used to map out the brightness inhomogeneities present on the surfaces of Ap/Bp stars, informing present models of atomic diffusion in their atmospheres. Finally, we review our current and ongoing studies, which lead to new insights on this topic., Comment: 4 pages, Conference proceedings: "Stars and their variability observed from space", Vienna, Austria, 2019
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- 2019
89. 68Ga-DOTATATE PET/CT for assessment of cardiac sarcoidosis: hidden opportunities?
- Author
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Monroy-Gonzalez, Andrea G., Erba, Paola A., and Slart, Riemer H. J. A.
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- 2023
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90. Conformational Dynamics of Lipoxygenases and Their Interaction with Biological Membranes
- Author
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Fulvio Erba, Giampiero Mei, Velia Minicozzi, Annalaura Sabatucci, Almerinda Di Venere, and Mauro Maccarrone
- Subjects
lipoxygenase ,membrane binding ,conformational flexibility ,interdomain interaction ,molecular dynamics ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Lipoxygenases (LOXs) are a family of enzymes that includes different fatty acid oxygenases with a common tridimensional structure. The main functions of LOXs are the production of signaling compounds and the structural modifications of biological membranes. These features of LOXs, their widespread presence in all living organisms, and their involvement in human diseases have attracted the attention of the scientific community over the last decades, leading to several studies mainly focused on understanding their catalytic mechanism and designing effective inhibitors. The aim of this review is to discuss the state-of-the-art of a different, much less explored aspect of LOXs, that is, their interaction with lipid bilayers. To this end, the general architecture of six relevant LOXs (namely human 5-, 12-, and 15-LOX, rabbit 12/15-LOX, coral 8-LOX, and soybean 15-LOX), with different specificity towards the fatty acid substrates, is analyzed through the available crystallographic models. Then, their putative interface with a model membrane is examined in the frame of the conformational flexibility of LOXs, that is due to their peculiar tertiary structure. Finally, the possible future developments that emerge from the available data are discussed.
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- 2024
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91. Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia
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Laura W. Dillon, Jake Higgins, Hassan Nasif, Megan Othus, Lan Beppu, Thomas H. Smith, Elizabeth Schmidt, Charles C. Valentine III, Jesse J. Salk, Brent L Wood, Harry P. Erba, Jerald P. Radich, and Christopher S. Hourigan
- Subjects
Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
The presence of measurable residual disease (MRD) is strongly associated with treatment outcomes in acute myeloid leukemia (AML). Despite the correlation with clinical outcomes, MRD assessment has yet to be standardized or routinely incorporated into clinical trials and discrepancies have been observed between different techniques for MRD assessment. In 62 patients with AML, aged 18-60 years, in first complete remission after intensive induction therapy on the randomized phase III SWOG-S0106 clinical trial (clinicaltrials gov. Identifier: NCT00085709), MRD detection by centralized, high-quality multiparametric flow cytometry was compared with a 29-gene panel utilizing duplex sequencing (DS), an ultrasensitive next-generation sequencing method that generates double-stranded consensus sequences to reduce false positive errors. MRD as defined by DS was observed in 22 (35%) patients and was strongly associated with higher rates of relapse (68% vs. 13%; hazard ratio [HR] =8.8; 95% confidence interval [CI]: 3.2-24.5; P
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- 2023
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92. Classical theories with entanglement
- Author
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D'Ariano, Giacomo Mauro, Erba, Marco, and Perinotti, Paolo
- Subjects
Quantum Physics ,Mathematical Physics - Abstract
We investigate operational probabilistic theories where the pure states of every system are the vertices of a simplex. A special case of such theories is that of classical theories, i.e. simplicial theories whose pure states are jointly perfectly discriminable. The usual Classical Theory satisfies also local discriminability. However, simplicial theories---including the classical ones---can violate local discriminability, thus admitting of entangled states. First, we prove sufficient conditions for the presence of entangled states in arbitrary probabilistic theories. Then, we prove that simplicial theories are necessarily causal, and this represents a no-go theorem for conceiving non-causal classical theories. We then provide necessary and sufficient conditions for simplicial theories to exhibit entanglement, and classify their system-composition rules. We conclude proving that, in simplicial theories, an operational formulation of the superposition principle cannot be satisfied, and that---under the hypothesis of $n$-local discriminability---no mixed state admits of a purification. Our results hold also in the general case where the sets of states fail to be convex., Comment: The definitions of simplicial and classical theories have been relaxed, in order to include the non-convex cases; the results hold also in the non-convex cases. Improved and extended presentation. Added results on superposition and purification. Enhanced the 'Discussion and Conclusions' section. Minor corrections. Layout fixed and mention to Ref. [13] corrected
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- 2019
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93. Constrained Concealment Attacks against Reconstruction-based Anomaly Detectors in Industrial Control Systems
- Author
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Erba, Alessandro, Taormina, Riccardo, Galelli, Stefano, Pogliani, Marcello, Carminati, Michele, Zanero, Stefano, and Tippenhauer, Nils Ole
- Subjects
Computer Science - Cryptography and Security ,Computer Science - Machine Learning - Abstract
Recently, reconstruction-based anomaly detection was proposed as an effective technique to detect attacks in dynamic industrial control networks. Unlike classical network anomaly detectors that observe the network traffic, reconstruction-based detectors operate on the measured sensor data, leveraging physical process models learned a priori. In this work, we investigate different approaches to evade prior-work reconstruction-based anomaly detectors by manipulating sensor data so that the attack is concealed. We find that replay attacks (commonly assumed to be very strong) show bad performance (i.e., increasing the number of alarms) if the attacker is constrained to manipulate less than 95% of all features in the system, as hidden correlations between the features are not replicated well. To address this, we propose two novel attacks that manipulate a subset of the sensor readings, leveraging learned physical constraints of the system. Our attacks feature two different attacker models: A white box attacker, which uses an optimization approach with a detection oracle, and a black box attacker, which uses an autoencoder to translate anomalous data into normal data. We evaluate our implementation on two different datasets from the water distribution domain, showing that the detector's Recall drops from 0.68 to 0.12 by manipulating 4 sensors out of 82 in WADI dataset. In addition, we show that our black box attacks are transferable to different detectors: They work against autoencoder-, LSTM-, and CNN-based detectors. Finally, we implement and demonstrate our attacks on a real industrial testbed to demonstrate their feasibility in real-time., Comment: Proceedings of the Annual Computer Security Applications Conference (ACSAC) 2020
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- 2019
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94. Intrinsic dimension estimation for locally undersampled data
- Author
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Erba, Vittorio, Gherardi, Marco, and Rotondo, Pietro
- Subjects
Computer Science - Machine Learning ,Condensed Matter - Disordered Systems and Neural Networks ,Statistics - Machine Learning - Abstract
High-dimensional data are ubiquitous in contemporary science and finding methods to compress them is one of the primary goals of machine learning. Given a dataset lying in a high-dimensional space (in principle hundreds to several thousands of dimensions), it is often useful to project it onto a lower-dimensional manifold, without loss of information. Identifying the minimal dimension of such manifold is a challenging problem known in the literature as intrinsic dimension estimation (IDE). Traditionally, most IDE algorithms are either based on multiscale principal component analysis (PCA) or on the notion of correlation dimension (and more in general on k-nearest-neighbors distances). These methods are affected, in different ways, by a severe curse of dimensionality. In particular, none of the existing algorithms can provide accurate ID estimates in the extreme locally undersampled regime, i.e. in the limit where the number of samples in any local patch of the manifold is less than (or of the same order of) the ID of the dataset. Here we introduce a new ID estimator that leverages on simple properties of the tangent space of a manifold to overcome these shortcomings. The method is based on the full correlation integral, going beyond the limit of small radius used for the estimation of the correlation dimension. Our estimator alleviates the extreme undersampling problem, intractable with other methods. Based on this insight, we explore a multiscale generalization of the algorithm. We show that it is capable of (i) identifying multiple dimensionalities in a dataset, and (ii) providing accurate estimates of the ID of extremely curved manifolds. In particular, we test the method on manifolds generated from global transformations of high-contrast images, relevant for invariant object recognition and considered a challenge for state-of-the-art ID estimators.
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- 2019
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95. Magnetic OB[A] Stars with TESS: probing their Evolutionary and Rotational properties (MOBSTER) - I. First-light observations of known magnetic B and A stars
- Author
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David-Uraz, A., Neiner, C., Sikora, J., Bowman, D. M., Petit, V., Chowdhury, S., Handler, G., Pergeorelis, M., Cantiello, M., Cohen, D. H., Erba, C., Keszthelyi, Z., Khalack, V., Kobzar, O., Kochukhov, O., Labadie-Bartz, J., Lovekin, C. C., MacInnis, R., Owocki, S. P., Pablo, H., Shultz, M. E., ud-Doula, A., Wade, G. A., and Collaboration, the MOBSTER
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
In this paper we introduce the MOBSTER collaboration and lay out its scientific goals. We present first results based on the analysis of nineteen previously known magnetic O, B and A stars observed in 2-minute cadence in sectors 1 and 2 of the Transiting Exoplanet Survey Satellite (TESS) mission. We derive precise rotational periods from the newly obtained light curves and compare them to previously published values. We also discuss the overall photometric phenomenology of the known magnetic massive and intermediate-mass stars and propose an observational strategy to augment this population by taking advantage of the high-quality observations produced by TESS., Comment: 15 pages, 3 figures, accepted for publication by MNRAS (2019 April 22)
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- 2019
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96. The Dyck bound in the concave 1-dimensional random assignment model
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Caracciolo, Sergio, D'Achille, Matteo P., Erba, Vittorio, and Sportiello, Andrea
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Condensed Matter - Disordered Systems and Neural Networks - Abstract
We consider models of assignment for random $N$ blue points and $N$ red points on an interval of length $2N$, in which the cost for connecting a blue point in $x$ to a red point in $y$ is the concave function $|x-y|^p$, for $0
1$, where the optimal matching is trivially determined, here the optimization is non-trivial. The purpose of this paper is to introduce a special configuration, that we call the \emph{Dyck matching}, and to study its statistical properties. We compute exactly the average cost, in the asymptotic limit of large $N$, together with the first subleading correction. The scaling is remarkable: it is of order $N$ for $p<\frac{1}{2}$, order $N \ln N$ for $p=\frac{1}{2}$, and $N^{\frac{1}{2}+p}$ for $p>\frac{1}{2}$, and it is universal for a wide class of models. We conjecture that the average cost of the Dyck matching has the same scaling in $N$ as the cost of the optimal matching, and we produce numerical data in support of this conjecture. We hope to produce a proof of this claim in future work., Comment: 31 pages, 5 figures
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- 2019
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97. Chirality from quantum walks without quantum coin
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D'Ariano, Giacomo Mauro, Erba, Marco, and Perinotti, Paolo
- Subjects
Quantum Physics - Abstract
Quantum walks (QWs) describe the evolution of quantum systems on graphs. An intrinsic degree of freedom---called the coin and represented by a finite-dimensional Hilbert space---is associated to each node. Scalar quantum walks are QWs with a one-dimensional coin. We propose a general strategy allowing one to construct scalar QWs on a broad variety of graphs, which admit embedding in Eulidean spaces, thus having a direct geometric interpretation. After reviewing the technique that allows one to regroup cells of nodes into new nodes, transforming finite spatial blocks into internal degrees of freedom, we prove that no QW with a two-dimensional coin can be derived from an isotropic scalar QW in this way. Finally we show that the Weyl and Dirac QWs can be derived from scalar QWs in spaces of dimension up to three, via our construction., Comment: 22 pages, 2 figures
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- 2019
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98. Thermoelasticity of Flexible Organic Crystals from Quasi-harmonic Lattice Dynamics: The Case of Copper(II) Acetylacetonate
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Maul, Jefferson, Ongari, Daniele, Moosavi, Seyed Mohamad, Smit, Berend, and Erba, Alessandro
- Subjects
Physical Sciences ,Chemical Sciences - Abstract
A computationally affordable approach, based on quasi-harmonic lattice dynamics, is presented for the quantum-mechanical calculation of thermoelastic moduli of flexible, stimuli-responsive, organic crystals. The methodology relies on the simultaneous description of structural changes induced by thermal expansion and strain. The complete thermoelastic response of the mechanically flexible metal-organic copper(II) acetylacetonate crystal is determined and discussed in the temperature range 0-300 K. The elastic moduli do not just shrink with temperature but they do so anisotropically. The present results clearly indicate the need for an explicit account of thermal effects in the simulation of mechanical properties of elastically flexible organic materials. Indeed, predictions from standard static calculations on this flexible metal-organic crystal are off by up to 100%.
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- 2020
99. Diagnostic and molecular testing patterns in patients with newly diagnosed acute myeloid leukemia in the Connect® MDS/AML Disease Registry
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Pollyea, Daniel A, George, Tracy I, Abedi, Mehrdad, Bejar, Rafael, Cogle, Christopher R, Foucar, Kathryn, Garcia‐Manero, Guillermo, Grinblatt, David L, Komrokji, Rami S, Maciejewski, Jaroslaw P, Revicki, Dennis A, Roboz, Gail J, Savona, Michael R, Scott, Bart L, Sekeres, Mikkael A, Thompson, Michael A, Kurtin, Sandra E, Louis, Chrystal U, Nifenecker, Melissa, Flick, E Dawn, Swern, Arlene S, Kiselev, Pavel, Steensma, David P, and Erba, Harry P
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Rare Diseases ,Childhood Leukemia ,Cancer ,Hematology ,Pediatric Cancer ,Pediatric ,Clinical Research ,acute myeloid leukemia ,diagnostic testing ,leukemia diagnosis ,leukemia therapy ,molecular testing ,registry ,Genetics ,Cardiovascular medicine and haematology - Abstract
Diagnostic and molecular genetic testing are key in advancing the treatment of acute myeloid leukemia (AML), yet little is known about testing patterns outside of clinical trials, especially in older patients. We analyzed diagnostic and molecular testing patterns over time in 565 patients aged ≥ 55 years with newly diagnosed AML enrolled in the Connect® MDS/AML Disease Registry (NCT01688011) in the United States. Diagnostic data were recorded at enrolment and compared with published guidelines. The percentage of bone marrow blasts was reported for 82.1% of patients, and cellularity was the most commonly reported bone marrow morphological feature. Flow cytometry, karyotyping, molecular testing, and fluorescence in situ hybridization were performed in 98.8%, 95.4%, 75.9%, and 75.7% of patients, respectively. Molecular testing was done more frequently at academic than community/government sites (84.3% vs 70.2%; P
- Published
- 2020
100. Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade.
- Author
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Tetreau, Guillaume, Banneville, Anne-Sophie, Andreeva, Elena A, Brewster, Aaron S, Hunter, Mark S, Sierra, Raymond G, Teulon, Jean-Marie, Young, Iris D, Burke, Niamh, Grünewald, Tilman A, Beaudouin, Joël, Snigireva, Irina, Fernandez-Luna, Maria Teresa, Burt, Alister, Park, Hyun-Woo, Signor, Luca, Bafna, Jayesh A, Sadir, Rabia, Fenel, Daphna, Boeri-Erba, Elisabetta, Bacia, Maria, Zala, Ninon, Laporte, Frédéric, Després, Laurence, Weik, Martin, Boutet, Sébastien, Rosenthal, Martin, Coquelle, Nicolas, Burghammer, Manfred, Cascio, Duilio, Sawaya, Michael R, Winterhalter, Mathias, Gratton, Enrico, Gutsche, Irina, Federici, Brian, Pellequer, Jean-Luc, Sauter, Nicholas K, and Colletier, Jacques-Philippe
- Subjects
NIH 3T3 Cells ,Cell Membrane ,Animals ,Humans ,Mice ,Disulfides ,Bacterial Proteins ,Endotoxins ,Insecticides ,Microscopy ,Atomic Force ,Crystallography ,X-Ray ,Protein Conformation ,Hydrogen-Ion Concentration ,Hemolysin Proteins ,HEK293 Cells ,Sf9 Cells ,Microscopy ,Atomic Force ,Crystallography ,X-Ray - Abstract
Cyt1Aa is the one of four crystalline protoxins produced by mosquitocidal bacterium Bacillus thuringiensis israelensis (Bti) that has been shown to delay the evolution of insect resistance in the field. Limiting our understanding of Bti efficacy and the path to improved toxicity and spectrum has been ignorance of how Cyt1Aa crystallizes in vivo and of its mechanism of toxicity. Here, we use serial femtosecond crystallography to determine the Cyt1Aa protoxin structure from sub-micron-sized crystals produced in Bti. Structures determined under various pH/redox conditions illuminate the role played by previously uncharacterized disulfide-bridge and domain-swapped interfaces from crystal formation in Bti to dissolution in the larval mosquito midgut. Biochemical, toxicological and biophysical methods enable the deconvolution of key steps in the Cyt1Aa bioactivation cascade. We additionally show that the size, shape, production yield, pH sensitivity and toxicity of Cyt1Aa crystals grown in Bti can be controlled by single atom substitution.
- Published
- 2020
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