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417 results on '"Endo, Ginji"'

51. Effectiveness of Arsenic Mitigation Program in Bangladesh : Relationship between Arsenic Concentrations in Well Water and Urine

Author

Habib, Ahsan, Hayashi, Tomoshige, Sato(Kogawa), Kyoko, Hata, Akihisa, Ikebe, Maiko, Rahman, Fashiur, Hassan, Parvez, Endo, Yoko, and Endo, Ginji

Subjects
inorganic chemicals, Bangladesh, integumentary system, Urinary arsenic level, Well water, Arsenic contamination
Abstract

Background : Arsenic in drinking water remains a major public problem in Bangladesh, although arsenic mitigation programs began there a decade ago. The purpose of this study was to examine the effectiveness of this program by determining the relationship between current arsenic levels in well water and the high level of urinary arsenic excretion. / Methods : A community-based cross-sectional study was conducted in the Pabna district of Bangladesh between May and July 2005. We included 174 married couples and collected their drinking water from 138 wells. The allowable limit for arsenic in drinking water is 50 μg/L in Bangladesh, while the normal level of urinary arsenic is ≦40 μg･1.5L^-1･day^-1 by Dhaka Community Hospital....

Published
2007

52. Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages.

Author

Zong, Cai, Kimura, Yusuke, Kinoshita, Kazuo, Takasu, Shigetada, Zhang, Xiao, Sakurai, Toshihiro, Sekido, Yoshitaka, Ichihara, Sahoko, Endo, Ginji, and Ichihara, Gaku

Subjects
DICHLOROPROPANE, CYTIDINE deaminase, MACROPHAGES, CARCINOGENS, CHOLANGIOCARCINOMA
Abstract

1,2-dichloropropane (1,2-DCP) was reclassified recently by IARC as a Group 1 carcinogen based on epidemiological studies on an outbreak of cholangiocarcinoma in offset-printing workers exposed to 1,2-DCP in Japan. However, the underlying mechanism of 1,2-DCP-induced cholangiocarcinoma remains obscure. A previous whole-genome mutation analysis of cholangiocarcinoma of 4 cases exposed to 1,2-DCP suggested the involvement of activation-induced cytidine deaminase (AID), based on specific signatures of mutation patterns. The objective of the present study is to determine whether exposure to 1,2-DCP induces expression of AID in human cholangiocytes. Human MMNK-1 cholangiocytes, differentiated THP-1 macrophages, and co-cultures of MMNK-1/THP-1 cells were exposed to 1,2-DCP at different concentrations and time intervals. The mRNA expression levels of AID and related genes were quantified by real-time PCR. Protein expression was measured by immunostaining. Alkaline Comet assay was performed to examine DNA damage. The results showed that 1,2-DCP alone did not change AID expression in MMNK-1 cholangiocytes. 1,2-DCP significantly increased pro-inflammatory cytokine TNF-α expression in THP-1 macrophages. TNF-α treatment upregulated expression of AID, NF-κB, and IκB in MMNK-1 cholangiocytes. SN50, a NF-κB inhibitor, significantly downregulated TNF-α-induced AID expression, suggesting the involvement of NF-κB pathway in TNF-α-induced AID expression. Exposure to 1,2-DCP significantly increased AID expression in MMNK-1 cholangiocytes co-cultured with THP-1 macrophages. Comet assay showed that 1,2-DCP-induced DNA damage in MMNK-1 cholangiocytes, as indicated by increased tail DNA% and tail moment, was enhanced when co-cultured with macrophages. The results suggest that inflammatory response of macrophages and consequent aberrant AID expression or DNA damage in the cholangiocytes underlie the mechanism of 1,2-DCP-induced cholangiocarcinoma in humans. [ABSTRACT FROM AUTHOR]

Published
2019
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59. Development of analytical method for biological monitoring of inorganic arsenic exposure using gas chromatography-mass spectrometry

Author

Sumino Kimiaki, Endo Yoko, Namera Akira, Endo Ginji, Sakui Norihiro, Takeuchi Akito, Imanaka Tsutoshi, Ota Hirokazu, and Kawasumi Yaeko

Subjects
Chromatography, chemistry, Inorganic arsenic, food and beverages, General Earth and Planetary Sciences, Dimethylarsinic Acid, chemistry.chemical_element, Urine, Monomethylarsonic acid, Gas chromatography–mass spectrometry, Arsenic, General Environmental Science
Abstract

[Background] Inorganic arsenic (iAs) is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in the human body, however, large amounts of DMA have been observed in the urine of...

Published
2013

60. ARSENIC METABOLITES IN HUMAN URINE AFTER INGESTION OF SASHIMI TSUNA FISH

Author

Fujitani Noboru, Yuko Yamano, Endo Ginji, Kenzo Yamanaka, Akihisa Hata, and Yoko Endo

Subjects
integumentary system, fungi, food and beverages, chemistry.chemical_element, Urine, Biology, chemistry, General Earth and Planetary Sciences, %22">Fish , Ingestion, Food science, SEAFOOD INGESTION, Tuna, Arsenic, General Environmental Science
Abstract

Background and Aims: The consumption of seafood including tuna is increasing in the world. Seafood contains large amounts of various arsenic compounds but the risk from seafood ingestion is not cle...

Published
2011

61. Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents

Author

Kubo, Shoji, primary, Takemura, Shigekazu, additional, Tanaka, Shogo, additional, Nishioka, Takayoshi, additional, Kinoshita, Masahiko, additional, Hamano, Genya, additional, Ito, Tokuji, additional, Yamamoto, Takatsugu, additional, Abue, Makoto, additional, Aoki, Masaru, additional, Nakagawa, Kei, additional, Hijioka, Susumu, additional, Miyamoto, Atsushi, additional, Osaki, Yukio, additional, Endo, Ginji, additional, and Kumagai, Shinji, additional

Published
2015
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67. Daily Alcohol Consumption and the Risk of Type 2 Diabetes

Author

HAYASHI, TOMOSHIGE, TSUMURA, KEI, OKADA, KUNIO, SUEMATSU, CHIKA, ENDO, GINJI, and FUJII, SATORU

Subjects
Diabetes -- Research, Health
Abstract

Recently moderate alcohol consumption among healthy people is reported to be associated with increased insulin sensitivity and a decreased plasma level of fasting insulin. Previous epidemiological findings on the association [...]

Published
1999

68. Occupational exposure limits for cumene, 2,4‐dichlorophenoxy acetic acid, silicon carbide whisker, benzyl alcohol, and methylamine, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications.

Author

Araki, Atsuko, Azuma, Kenichi, Endo, Ginji, Endo, Yoko, Fukushima, Tetsuhito, Hara, Kunio, Harada, Koji, Hori, Hajime, Horie, Seichi, Ichiba, Masayoshi, Ichihara, Gaku, Ikeda, Masayuki, Ito, Akiyoshi, Ito, Yuki, Iwasawa, Satoko, Kakumu, Takeyasu, Kamijima, Michihiro, Karita, Kanae, Katoh, Takahiko, and Kawai, Toshio

Subjects
ACETIC acid, SILICON carbide, BENZYL alcohol, METHYLAMINES, CARCINOGENICITY
Published
2019
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83. Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers.

Author

Shinji Kumagai, Tomotaka Sobue, Takeshi Makiuchi, Shoji Kubo, Shinichiro Uehara, Tomoshige Hayashi, Kyoko Kogawa Sato, Ginji Endo, Kumagai, Shinji, Sobue, Tomotaka, Makiuchi, Takeshi, Kubo, Shoji, Uehara, Shinichiro, Hayashi, Tomoshige, Sato, Kyoko Kogawa, and Endo, Ginji

Abstract

Objectives: This study aimed to evaluate the relationship between cumulative exposure to 1,2-dichloropropane (1,2-DCP) and incidence risk of cholangiocarcinoma among workers in the offset proof-printing section of a small printing company in Osaka, Japan.Methods: We identified 95 workers of a printing company (78 men and 17 women) who had been exposed to 1,2-DCP between 1987 and 2006, and calculated the standardised incidence ratio (SIR) of cholangiocarcinoma from 1987 to 2012. We estimated cumulative exposure to 1,2-DCP and calculated SIRs in four exposure categories. We also calculated incidence rate ratios (RRs) adjusted by sex, age, calendar year and dichloromethane (DCM) exposure for three exposure categories using Poisson regression analysis.Results: Cumulative exposures to 1,2-DCP ranged from 32 to 3433 ppm-years (mean, 851 ppm-years) and the SIR was 1171 (95% CI 682 to 1875). In the analysis of the four exposure categories, SIRs increased significantly in the three highest exposure categories, but not in the lowest category. Adjusted RRs in the middle and high exposure categories were 14.9 (95% CI 4.1 to 54.3) and 17.1 (95% CI 3.8 to 76.2), respectively, in the analysis without lag time, and were 11.4 (95% CI 3.3 to 39.6) and 32.4 (95% CI 6.4 to 163.9), respectively, in the analysis with a 5-year lag. The trend analysis revealed a significant increase in RR in association with increasing cumulative exposure to 1,2-DCP. DCM exposure was not significantly associated with the development of cholangiocarcinoma.Conclusions: The present study demonstrated an exposure-response relationship between exposure to 1,2-DCP and the development of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]

Published
2016
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94. Increase of urinary albumin in workers exposed to lead

Author

Endo Ginji and Konishi Yoshitsugu Kiyota Atsuhiko Horiguchi Shun'ichi

Subjects
職業病・職業性障害 － 職業中毒, Lead, Workers, Urinary albumin, Kidney, Nephrotoxicity, 労働科学－その他
Published
1993

95. A 40-year review of health of workers at a lead reclamation factory

Author

Horiguchi Shun'ichi and Kurosawa Katsuya Endo Ginji Kiyota Ikuko Teramoto Keiko Shinagawa Kozo Wakitani Fumiko Fukui Mitsuru

Subjects
職業病・職業性障害 － 職業中毒, Lead reclamation, Lead workers, Lead exposure, Industrial health, 労働科学－その他
Published
1993

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