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Your search keyword '"Eldridge, Gary R."' showing total 52 results
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52 results on '"Eldridge, Gary R."'

51. Antibacterial activity of Taxodium ascendensDiterpenes against Methicillin-resistant Staphylococcus aureus

Author

Starks, Courtney M., Norman, Vanessa L., Williams, Russell B., Goering, Matt G., Rice, Stephanie M., O'Neil-Johnson, Mark, and Eldridge, Gary R.

Abstract

One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.

Published
2014
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52. Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus.

Author

Garo E, Hung CS, Williams RB, Olson KM, Hu JF, Rice SM, Hough GW, Goering MG, O'Neil-Johnson M, Eldridge GR, and Starks CM

Subjects
Anti-Bacterial Agents isolation & purification, Disaccharides isolation & purification, Disaccharides pharmacology, Glycosides isolation & purification, Glycosides pharmacology, Plant Extracts chemistry, Plant Extracts isolation & purification, Triterpenes isolation & purification, Vancomycin pharmacology, Dammaranes, Anti-Bacterial Agents pharmacology, Methicillin-Resistant Staphylococcus aureus drug effects, Plant Extracts pharmacology, Salicaceae chemistry, Triterpenes pharmacology
Abstract

Drug-resistant bacteria are becoming more prevalent both in the community and in hospitals. In a search for new antibiotic leads, we used a high-throughput natural products chemistry approach to isolate one new (1) and two known (2, 3) dammarane-type triterpenes with mass-limited material from the African plant Oncoba manii. The new compound was determined by spectroscopic methods to be 1beta,2alpha,3beta,20(R)-tetrahydroxydammar-24-ene 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranoside. Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA).

Published
2009
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