370 results on '"El Hachem, M"'
Search Results
52. Skin manifestations of COVID‐19 in children: Part 3.
- Author
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Andina, D., Belloni‐Fortina, A., Bodemer, C., Bonifazi, E., Chiriac, A., Colmenero, I., Diociaiuti, A., El‐Hachem, M., Fertitta, L., Gysel, D., Hernández‐Martín, A., Hubiche, T., Luca, C., Martos‐Cabrera, L., Maruani, A., Mazzotta, F., Akkaya, A. D., Casals, M., Ferrando, J., and Grimalt, R.
- Subjects
CUTANEOUS manifestations of general diseases ,COVID-19 ,ERYTHEMA multiforme ,COVID-19 pandemic ,SARS-CoV-2 ,SYMPTOMS - Abstract
Summary: The current COVID‐19 pandemic is caused by the SARS‐CoV‐2 coronavirus. The initial recognized symptoms were respiratory, sometimes culminating in severe respiratory distress requiring ventilation, and causing death in a percentage of those infected. As time has passed, other symptoms have been recognized. The initial reports of cutaneous manifestations were from Italian dermatologists, probably because Italy was the first European country to be heavily affected by the pandemic. The overall clinical presentation, course and outcome of SARS‐CoV‐2 infection in children differ from those in adults as do the cutaneous manifestations of childhood. In this review, we summarize the current knowledge on the cutaneous manifestations of COVID‐19 in children after thorough and critical review of articles published in the literature and from the personal experience of a large panel of paediatric dermatologists in Europe. In Part 1, we discuss one of the first and most widespread cutaneous manifestations of COVID‐19, chilblain‐like lesions, and in Part 2 we expanded to other manifestations, including erythema multiforme, urticaria and Kawasaki disease‐like inflammatory multisystemic syndrome. In this part of the review, we discuss the histological findings of COVID‐19 manifestations, and the testing and management of infected children for both COVID‐19 and any other pre‐existing conditions. Click here for the corresponding questions to this CME article. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
53. Skin manifestations of COVID‐19 in children: Part 2.
- Author
-
Andina, D., Belloni‐Fortina, A., Bodemer, C., Bonifazi, E., Chiriac, A., Colmenero, I., Diociaiuti, A., El‐Hachem, M., Fertitta, L., Gysel, D., Hernández‐Martín, A., Hubiche, T., Luca, C., Martos‐Cabrera, L., Maruani, A., Mazzotta, F., Akkaya, A. D., Casals, M., Ferrando, J., and Grimalt, R.
- Subjects
CUTANEOUS manifestations of general diseases ,COVID-19 ,COVID-19 pandemic ,MUCOCUTANEOUS lymph node syndrome ,URTICARIA ,SARS-CoV-2 ,SYMPTOMS - Abstract
Summary: The current COVID‐19 pandemic is caused by the SARS‐CoV‐2 coronavirus. The initial recognized symptoms were respiratory, sometimes culminating in severe respiratory distress requiring ventilation, and causing death in a percentage of those infected. As time has passed, other symptoms have been recognized. The initial reports of cutaneous manifestations were from Italian dermatologists, probably because Italy was the first European country to be heavily affected by the pandemic. The overall clinical presentation, course and outcome of SARS‐CoV‐2 infection in children differ from those in adults, as do the cutaneous manifestations of childhood. In this review, we summarize the current knowledge on the cutaneous manifestations of COVID‐19 in children after thorough and critical review of articles published in the literature and from the personal experience of a large panel of paediatric dermatologists in Europe. In Part 1, we discussed one of the first and most widespread cutaneous manifestations of COVID‐19, chilblain‐like lesions. In this part of the review, we describe other manifestations, including erythema multiforme, urticaria and Kawasaki disease‐like inflammatory multisystemic syndrome. In Part 3, we discuss the histological findings of COVID‐19 manifestations, and the testing and management of infected children for both COVID‐19 and any other pre‐existing conditions. Click here for the corresponding questions to this CME article. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
54. Skin manifestations of COVID‐19 in children: Part 1.
- Author
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Andina, D., Belloni‐Fortina, A., Bodemer, C., Bonifazi, E., Chiriac, A., Colmenero, I., Diociaiuti, A., El‐Hachem, M., Fertitta, L., Gysel, D., Hernández‐Martín, A., Hubiche, T., Luca, C., Martos‐Cabrera, L., Maruani, A., Mazzotta, F., Akkaya, A. D., Casals, M., Ferrando, J., and Grimalt, R.
- Subjects
CUTANEOUS manifestations of general diseases ,COVID-19 ,COVID-19 pandemic ,MUCOCUTANEOUS lymph node syndrome ,URTICARIA ,SARS-CoV-2 ,SYMPTOMS - Abstract
Summary: The current COVID‐19 pandemic is caused by the SARS‐CoV‐2 coronavirus. The initial recognized symptoms were respiratory, sometimes culminating in severe respiratory distress requiring ventilation, and causing death in a percentage of those infected. As time has passed, other symptoms have been recognized. The initial reports of cutaneous manifestations were from Italian dermatologists, probably because Italy was the first European country to be heavily affected by the pandemic. The overall clinical presentation, course and outcome of SARS‐CoV‐2 infection in children differ from those in adults as do the cutaneous manifestations of childhood. In this review, we summarize the current knowledge on the cutaneous manifestations of COVID‐19 in children after thorough and critical review of articles published in the literature and from the personal experience of a large panel of paediatric dermatologists in Europe. In Part 1, we discuss one of the first and most widespread cutaneous manifestation of COVID‐19, chilblain‐like lesions. In Part 2, we review other manifestations, including erythema multiforme, urticaria and Kawasaki disease‐like inflammatory multisystemic syndrome, while in Part 3, we discuss the histological findings of COVID‐19 manifestations, and the testing and management of infected children, for both COVID‐19 and any other pre‐existing conditions. Click here for the corresponding questions to this CME article. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
55. A position paper on the management of itch and pain in atopic dermatitis from the International Society of Atopic Dermatitis (ISAD)/Oriented Patient‐Education Network in Dermatology (OPENED) task force.
- Author
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Misery, L., Belloni Fortina, A., El Hachem, M., Chernyshov, P., Kobyletzki, L., Heratizadeh, A., Marcoux, D., Aoki, V., Zaniboni, M.C., Stalder, J.‐F., and Eichenfield, L.F.
- Subjects
ATOPIC dermatitis ,PAIN management ,TASK forces ,QUALITY of life ,DERMATOLOGY ,ITCHING - Abstract
Atopic dermatitis (AD) is a disease that can have a high impact on quality of life, especially due to itch and skin pain. This paper utilizes expertise from members of the International Society of Atopic Dermatitis (ISAD)/Oriented Patient‐Education Network in Dermatology (OPENED) task force to review the epidemiology, pathophysiology and exacerbating factors of itch and pain in atopic dermatitis. General principles of treatment are provided, as well as a more detailed evaluation of topical and systemic therapies. Educational and psychological approaches to itch and pain in atopic dermatitis are proposed, along with expert recommendations for the management of itch and pain in atopic dermatitis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
56. Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I - definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase
- Author
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Marchesi, A, Tarissi de Jacobis, I, Rigante, Donato, Rimini, A, Malorni, W, Corsello, G, Bossi, G, Buonuomo, S, Cardinale, F, Cortis, E, De Benedetti, F, De Zorzi, A, Duse, M, Del Principe, D, Dellepiane, Rm, D’Isanto, L, El Hachem, M, Esposito, S, Falcini, F, Giordano, U, Maggio, Mc, Mannarino, S, Marseglia, G, Martino, S, Marucci, G, Massaro, R, Pescosolido, C, Pietraforte, D, Pietrogrande, Mc, Salice, P, Secinaro, A, Straface, E, Villani, A, Rigante D (ORCID:0000-0001-7032-7779), Marchesi, A, Tarissi de Jacobis, I, Rigante, Donato, Rimini, A, Malorni, W, Corsello, G, Bossi, G, Buonuomo, S, Cardinale, F, Cortis, E, De Benedetti, F, De Zorzi, A, Duse, M, Del Principe, D, Dellepiane, Rm, D’Isanto, L, El Hachem, M, Esposito, S, Falcini, F, Giordano, U, Maggio, Mc, Mannarino, S, Marseglia, G, Martino, S, Marucci, G, Massaro, R, Pescosolido, C, Pietraforte, D, Pietrogrande, Mc, Salice, P, Secinaro, A, Straface, E, Villani, A, and Rigante D (ORCID:0000-0001-7032-7779)
- Abstract
The primary purpose of these practical guidelines related to Kawasaki disease (KD) is to contribute to prompt diagnosis and appropriate treatment on the basis of different specialists’ contributions in the field. A set of 40 recommendations is provided, divided in two parts: the first describes the definition of KD, its epidemiology, etiopathogenetic hints, presentation, clinical course and general management, including treatment of the acute phase, through specific 23 recommendations. Their application is aimed at improving the rate of treatment with intravenous immunoglobulin and the overall potential development of coronary artery abnormalities in KD. Guidelines, however, should not be considered a norm that limits treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient’s condition, and disease severity or complications.
- Published
- 2018
57. Kawasaki disease: guidelines of the Italian Society of Pediatrics, part II - treatment of resistant forms and cardiovascular complications, follow-up, lifestyle and prevention of cardiovascular risks
- Author
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Marchesi, A, Tarissi de Jacobis, I, Rigante, Donato, Rimini, A, Malorni, W, Corsello, G, Bossi, G, Buonuomo, S, Cardinale, F, Cortis, E, De Benedetti, F, De Zorzi, A, Duse, M, Del Principe, D, Dellepiane, Rm, D’Isanto, L, El Hachem, M, Esposito, S, Falcini, F, Giordano, U, Maggio, Mc, Mannarino, S, Marseglia, G, Martino, S, Marucci, G, Massaro, R, Pescosolido, C, Pietraforte, D, Pietrogrande, Mc, Salice, P, Secinaro, A, Straface, E, Villani, A, Rigante D (ORCID:0000-0001-7032-7779), Marchesi, A, Tarissi de Jacobis, I, Rigante, Donato, Rimini, A, Malorni, W, Corsello, G, Bossi, G, Buonuomo, S, Cardinale, F, Cortis, E, De Benedetti, F, De Zorzi, A, Duse, M, Del Principe, D, Dellepiane, Rm, D’Isanto, L, El Hachem, M, Esposito, S, Falcini, F, Giordano, U, Maggio, Mc, Mannarino, S, Marseglia, G, Martino, S, Marucci, G, Massaro, R, Pescosolido, C, Pietraforte, D, Pietrogrande, Mc, Salice, P, Secinaro, A, Straface, E, Villani, A, and Rigante D (ORCID:0000-0001-7032-7779)
- Abstract
This second part of practical Guidelines related to Kawasaki disease (KD) has the goal of contributing to prompt diagnosis and most appropriate treatment of KD resistant forms and cardiovascular complications, including non-pharmacologic treatments, follow-up, lifestyle and prevention of cardiovascular risks in the long-term through a set of 17 recommendations. Guidelines, however, should not be considered a norm that limits the treatment options of pediatricians and practitioners, as treatment modalities other than those recommended may be required as a result of peculiar medical circumstances, patient’s condition, and disease severity or individual complications.
- Published
- 2018
58. Are SARS‐CoV‐2 IgA antibodies in paediatric patients with chilblain‐like lesions indicative of COVID‐19 asymptomatic or paucisymptomatic infection?
- Author
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Diociaiuti, A., Giancristoforo, S., Terreri, S., Corbeddu, M., Concato, C., Ciofi Degli Atti, M., Zambruno, G., Carsetti, R., and El Hachem, M.
- Subjects
CHILD patients ,COVID-19 ,SARS-CoV-2 ,IMMUNOGLOBULIN A ,IMMUNOGLOBULINS - Abstract
Are SARS-CoV-2 IgA antibodies in paediatric patients with chilblain-like lesions indicative of COVID-19 asymptomatic or paucisymptomatic infection? Dear Editor, Acral chilblain-like lesions in young patients are one of the commonest skin manifestations reported during COVID-19 pandemic.1-3 Despite the temporal and spatial correlation between the outbreak of pernio-like and the pandemic, the relationship with COVID-19 remains uncertain. Three patients of group B reported flu-like symptoms 3-4 weeks before skin lesion onset, and a single patient developed chilblain after proving positive to SARS-CoV-2. [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF
59. Giant congenital exophytic strawberry‐like mass in a newborn.
- Author
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Carnevale, C., Diociaiuti, A., Retrosi, C., Gualdi, G., Fabiano, A., Stracuzzi, A., and El Hachem, M.
- Subjects
HAMARTOMA ,NEWBORN infants ,BENIGN tumors - Abstract
GLO:DF2/01jan22:ced14814-fig-0001.jpg PHOTO (COLOR): 1 (a,b) Strawberry-like, reniform and pedunculated skin tumour measuring 80 × 50 × 35 mm on the right paravertebral lumbosacral area. gl Histopathological findings Histological examination showed a well-circumscribed dermal lesion composed of multiple folliculosebaceous units, with frequent cystic dilated hair infundibules (Fig. Question 2 What is the most useful investigation for diagnosis of folliculosebaceous cystic hamartoma (FSCH)? Ultrasonography during the fifth month of pregnancy had not detected the mass; however, at birth, a purplish-red, reniform, nodular and pedunculated skin tumour measuring 80 × 50 × 35 mm was visible on the right paravertebral lumbosacral area. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF
60. Linee Guida SICVE: 11. Anomalie vascolari
- Author
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Stillo F., Amato B., Baraldini V., Bianchini G., Dalmonte P., Gandolfo C., El Hachem M., Mattassi R., Rollo M., Vaghi M., Vercellio G., Stillo, F., Amato, B., Baraldini, V., Bianchini, G., Dalmonte, P., Gandolfo, C., El Hachem, M., Mattassi, R., Rollo, M., Vaghi, M., and Vercellio, G.
- Subjects
Linee-guida, Anomalie vascolari - Abstract
Gli obiettivi principali delle presenti Linee Guida per la gestione diagnostico-terapeutica delle anoma- lie vascolari sono: — indicare i criteri di classi cazione per un cor- retto inquadramento nosologico di tali patologie; — suggerire protocolli diagnostici speci ci per ottimizzare l’iter degli esami strumentali; — de nire le indicazioni e i risultati delle diffe- renti metodiche di trattamento per indirizzare verso la strategia terapeutica più idonea nei vari casi.
- Published
- 2015
61. Clinical practice guidelines for laboratory diagnosis of epidermolysis bullosa.
- Author
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Has, C., Liu, L., Bolling, M.C., Charlesworth, A.V., El Hachem, M., Escámez, M.J., Fuentes, I., Büchel, S., Hiremagalore, R., Pohla‐Gubo, G., Akker, P.C., Wertheim‐Tysarowska, K., and Zambruno, G.
- Subjects
CLINICAL pathology ,GUIDELINES ,EPIDERMOLYSIS bullosa - Abstract
Linked Comment: Uitto. Br J Dermatol 2020; 182:526–527. Plain language summary available online [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
62. PSS2 - VALIDATION STUDY OF AN INFANTILE HEMANGIOMA (IH) SCORING TOOL FOR PRIMARY CLINICIANS TO IDENTIFY PATIENTS REQUIRING REFERRAL TO EXPERT CENTERS
- Author
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Baselga, E., primary, Boon, L.M., additional, Weibel, L., additional, EL Hachem, M., additional, Leaute-Labreze, C., additional, Troilius, A., additional, Van Der Vleuten, C., additional, Rössler, J., additional, Auges, M., additional, Zkik, A., additional, Chalem, Y., additional, Zumaglini, F., additional, and Delarue, A., additional
- Published
- 2018
- Full Text
- View/download PDF
63. Human Herpesvirus-8 Serology in Pediatric Organ Transplantation
- Author
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Concato, C., Diociaiuti, A., Parisi, F., Giraldi, L., Ciasulli, A., Menichella, D., and El Hachem, M.
- Published
- 2008
- Full Text
- View/download PDF
64. Autosomal recessive epidermolysis bullosa simplex due to KRT14 mutation: two large Palestinian families and literature review
- Author
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Diociaiuti, A., primary, Castiglia, D., additional, Naim, M., additional, Condorelli, A.G., additional, Zambruno, G., additional, and El Hachem, M., additional
- Published
- 2017
- Full Text
- View/download PDF
65. Novel PNPLA1 mutations in two Italian siblings with autosomal recessive congenital ichthyosis
- Author
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Diociaiuti, A., primary, Pisaneschi, E., additional, Zambruno, G., additional, Angioni, A., additional, Novelli, A., additional, Boldrini, R., additional, and El Hachem, M., additional
- Published
- 2017
- Full Text
- View/download PDF
66. IgA tracheobronchial deposits underlie respiratory compromise in neonatal linear IgA bullous dermatosis
- Author
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Diociaiuti, A., primary, Zambruno, G., additional, Diomedi Camassei, F., additional, Di Zenzo, G., additional, Capolupo, I., additional, Stoppa, F., additional, Forziati, V., additional, and El Hachem, M., additional
- Published
- 2017
- Full Text
- View/download PDF
67. Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra
- Author
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Oranges, T., primary, Insalaco, A., additional, Diociaiuti, A., additional, Carnevale, C., additional, Strippoli, R., additional, Zambruno, G., additional, Tomà, P., additional, and El Hachem, M., additional
- Published
- 2016
- Full Text
- View/download PDF
68. Consensus Conference Italiana 'La gestione clinica della dermatite atopica in età pediatrica'
- Author
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Galli, E., Neri, I., Barone, M., Belloni Fortina, A., Bernardini, R., Berti, I., Boner, A., Caffarelli, C., Calamelli, E., Capra, L., Carello, R., Pasquale Comberiati, Diociaiuti, A., El Hachem, M., Fontana, E., Gruber, M., Maiello, N., Meglio, P., Patrizi, A., Diego Peroni, Ricci, G., Scarponi, D., Wielander, I., Baldo, E., Galli, Elena, Neri, Iria, Barone, Maurizio, Fortina, Anna Belloni, Bernardini, Roberto, Berti, Irene, Boner, Attilio, Caffarelli, Carlo, Calamelli, Elisabetta, Capra, Lucetta, Carello, Rossella, Comberiati, Pasquale, Diociaiuti, Andrea, Hachem, Maya El, Fontana, Elena, Gruber, Michaela, Maiello, Nunzia, Meglio, Paolo, Patrizi, Annalisa, Peroni, Diego, Ricci, Giampaolo, Scarponi, Dorella, Wielander, Ingrid, and Baldo, Ermanno.
- Subjects
età pediatrica ,Socio-culturale ,dermatite atopica ,NA ,dermatite atopica, età pediatrica - Abstract
NA
- Published
- 2015
69. Management of congenital ichthyoses: European guidelines of care, part two.
- Author
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Mazereeuw‐Hautier, J., Hernández‐Martín, A., O'Toole, E.A., Bygum, A., Amaro, C., Aldwin, M., Audouze, A., Bodemer, C., Bourrat, E., Diociaiuti, A., Dolenc‐Voljč, M., Dreyfus, I., El Hachem, M., Fischer, J., Ganemo, A., Gouveia, C., Gruber, R., Hadj‐Rabia, S., Hohl, D., and Jonca, N.
- Subjects
ICHTHYOSIS - Abstract
Summary: These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016, and a consensus on the discussions. These guidelines summarize evidence and expert‐based recommendations and intend to help clinicians with the management of these rare and often complex diseases. These guidelines comprise two sections. This is part two, covering the management of complications and the particularities of some forms of congenital ichthyosis. What's already known about this topic? Various symptomatic treatment options exist for congenital ichthyoses, but there are no European guidelines. What does this study add? These European guidelines for the management of congenital ichthyosis may help to improve outcomes and quality of life for patients. Linked Comment:Akiyama. Br J Dermatol 2019; 180:449–450. Plain language summary available online [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
70. Management of congenital ichthyoses: European guidelines of care, part one.
- Author
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Mazereeuw‐Hautier, J., Vahlquist, A., Traupe, H., Bygum, A., Amaro, C., Aldwin, M., Audouze, A., Bodemer, C., Bourrat, E., Diociaiuti, A., Dolenc‐Voljc, M., Dreyfus, I., El Hachem, M., Fischer, J., Gånemo, A., Gouveia, C., Gruber, R., Hadj‐Rabia, S., Hohl, D., and Jonca, N.
- Subjects
GUIDELINES - Abstract
Summary: These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016 and a consensus on the discussions. They summarize evidence and expert‐based recommendations and are intended to help clinicians with the management of these rare and often complex diseases. These guidelines comprise two sections. This is part one, covering topical therapies, systemic therapies, psychosocial management, communicating the diagnosis and genetic counselling. Linked Comment: Levy. Br J Dermatol 2019; 180:253. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
71. Cushing’s Syndrome in a 6-month-old Boy: A Rare Side-effect due to Inadequate use of Topical Corticosteroids
- Author
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Cappa M, Bizzarri C, Ciccone S, El Hachem M, and Romana Marini
- Subjects
Male ,Hypothalamo-Hypophyseal System ,Pediatrics ,medicine.medical_specialty ,Hydrocortisone ,Side effect ,Treatment outcome ,MEDLINE ,Pituitary-Adrenal System ,030209 endocrinology & metabolism ,Dermatology ,Administration, Cutaneous ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Adrenal Cortex Hormones ,Humans ,Medicine ,Cushing Syndrome ,Betamethasone Valerate ,S syndrome ,business.industry ,Infant ,General Medicine ,Treatment Outcome ,business - Published
- 2016
72. Generalized Arterial Calcification of Infancy (GACI) a rare case of neonatal acute heart failure: Molecular analysis and role for cardiac transplantation
- Author
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Francalanci, P., Giovannoni, I., paola cogo, Amodeo, A., Secinaro, A., El-Hachem, M., Bizzarri, C., Boldrini, R., and Callea, F.
- Published
- 2014
73. Linee guida. Diagnosi delle epidermolisi bollose ereditarie
- Author
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Angelo, C., Barlati, Sergio, Bonifazi, E., Castiglia, D., Castori, M., Colombi, Marina, Dalla Piccola, B., Diaociaiuti, A., Drera, Bruno Angelo, El Hachem, M., Picozzi, M., Polizzi, A., Salerno, P., Tadini, G., Villani, A., Zambruno, G., and Zotti, P.
- Subjects
Epidermolisi bollose ereditarie ,Linee guida ,Diagnosi, Test genetici ,Test genetici ,Diagnosi - Published
- 2011
74. Acral skin atrophy in an infant: an early clue to Kindler syndrome diagnosis
- Author
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Diociaiuti, A., primary, Zambruno, G., additional, Giancristoforo, S., additional, Proto, V., additional, Boldrini, R., additional, Castiglia, D., additional, and El Hachem, M., additional
- Published
- 2015
- Full Text
- View/download PDF
75. Electrochemotherapy, a potential new treatment for the management of squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa: report of three cases
- Author
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Diociaiuti, A., primary, Rotunno, R., additional, El Hachem, M., additional, Latorre, S., additional, Cozza, R., additional, and Curatolo, P., additional
- Published
- 2015
- Full Text
- View/download PDF
76. Preemptive liver transplantation in a child with familial hypercholesterolemia
- Author
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Maiorana, A, Nobili, V, CALANDRA BUONAURA, Sebastiano, Francalanci, P, Bernabei, S, El Hachem, M, Monti, L, Gennari, F, Torre, G, de Ville de Goyet, J, and Bartuli, A.
- Subjects
cardiovascular risk ,differential ,pediatrics ,diagnosis ,hyperlipoproteinemia type ii ,ldl-apheresis ,preschool ,time factors ,ldl cholesterol ,needle ,LDL-apheresis ,xanthomatosis ,familial hypercholesterolemia,LDL cholesterol,LDL-apheresis,liver transplantation,cardiovascular risk ,severity of illness index ,biopsy ,humans ,blood component removal ,child ,familial hypercholesterolemia ,liver transplantation ,cholesterol ,risk assessment ,Settore MED/20 - Chirurgia Pediatrica e Infantile ,ldl ,follow-up studies ,homozygote ,female ,LDL cholesterol ,biopsy, needle ,child, preschool ,cholesterol, ldl ,diagnosis, differential ,immunohistochemistry ,treatment outcome ,pediatrics, perinatology and child health ,transplantation ,perinatology and child health - Published
- 2010
77. Cost-Utility Analysis Comparing Propranolol With Corticosteroids in the Treatment of Proliferating Infantile Hemangioma in Italy
- Author
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Paragò, V., primary, El, Hachem M., additional, Bonamonte, D., additional, Diociaiuti, A., additional, and Teruzzi, C., additional
- Published
- 2014
- Full Text
- View/download PDF
78. The Italian Registry of Hereditary Epidermolysis Bullosa
- Author
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Tadini, G, Gualandri, L, Colombi, Marina, Paradisi, M, Angelo, C, Zambruno, G, Castiglia, G, Annicchiarico, G, El Hachem, M, Gardella, Rita, Barlati, Sergio, Naldi, L, Bonifazi, E, Garofano, L, Stella, M, Moretti, G, Cavalli, R, Cambiaghi, S, Percivalle, S, Bellinvia, M, Di Benedetto, A, Locatelli, A, Lunardon, L, Bruni, E, Patrizi, A, Lembo, G, and Cainelli, T.
- Subjects
Epidermolisi bollosa ,registro ,epidemiologia - Published
- 2005
79. Facial comedonal acne in orofaciodigital syndrome type 1 caused by a novel frameshift variant in OFD1.
- Author
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Rotunno, R., Diociaiuti, A., Agolini, E., Latorre, S., Carnevale, C., Novelli, A., El Hachem, M., and Castori, M.
- Subjects
AGENESIS of corpus callosum ,ACNE ,SYNDROMES - Abstract
The article presents a case study of a 4-month-old girl with cleft palate and other anomalies. It discusses that the girl presented bifid tongue with nodules, cleft palate and minor digital anomalies. It mentions that physical examination showed thin, wiry and sparse hair of the alae nasi, long philtrum, pseudocleft of the upper lip and depressions of the lower lip. It also mentions the need of essential for early diagnosis and appropriate genetic counselling for oro–facial–digital syndromes.
- Published
- 2019
- Full Text
- View/download PDF
80. Frequent Occurrence of Aplasia Cutis Congenita in Bullous Dermolysis of the Newborn
- Author
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Diociaiuti, A, primary, Castiglia, D, additional, Giancristoforo, S, additional, Guerra, L, additional, Proto, V, additional, Dotta, A, additional, Boldrini, R, additional, Zambruno, G, additional, and El Hachem, M, additional
- Published
- 2014
- Full Text
- View/download PDF
81. Disseminated intravascular coagulation during chickenpox. Description of a case in a child
- Author
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Tucciarone, L., Tomassini, A., Colasanti, A., Sabbi, T., Iacobini, Metello, and EL HACHEM, M.
- Published
- 2001
82. Epidermolysis bullosa simplex withPLECmutations: new phenotypes and new mutations
- Author
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Charlesworth, A., primary, Chiaverini, C., additional, Chevrant-Breton, J., additional, DelRio, M., additional, Diociaiuti, A., additional, Dupuis, R.P., additional, El Hachem, M., additional, Le Fiblec, B., additional, Sankari-Ho, A.M., additional, Valhquist, A., additional, Wierzbicka, E., additional, Lacour, J.P., additional, and Meneguzzi, G., additional
- Published
- 2013
- Full Text
- View/download PDF
83. The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitis
- Author
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Fortugno, P., primary, Furio, L., additional, Teson, M., additional, Berretti, M., additional, El Hachem, M., additional, Zambruno, G., additional, Hovnanian, A., additional, and D'Alessio, M., additional
- Published
- 2012
- Full Text
- View/download PDF
84. PA84 ESOPHAGEAL STENOSIS IN EPIDERMOLYSIS BULLOSA: A CHALLENGE FOR THE ENDOSCOPIST
- Author
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Caldaro, T., primary, Romeo, E., additional, Foschia, F., additional, De Angelis, P., additional, Torroni, F., additional, Federici di Abriola, G., additional, El Hachem, M., additional, Ciasulli, A., additional, Angelo, C., additional, and Dall'Oglio, L., additional
- Published
- 2010
- Full Text
- View/download PDF
85. Herlitz junctional epidermolysis bullosa: laminin-5 mutational profile and carrier frequency in the Italian population
- Author
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Castori, M., primary, Floriddia, G., additional, De Luca, N., additional, Pascucci, M., additional, Ghirri, P., additional, Boccaletti, V., additional, El Hachem, M., additional, Zambruno, G., additional, and Castiglia, D., additional
- Published
- 2007
- Full Text
- View/download PDF
86. PIH41 - Cost-Utility Analysis Comparing Propranolol With Corticosteroids in the Treatment of Proliferating Infantile Hemangioma in Italy
- Author
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Paragò, V., El, Hachem M., Bonamonte, D., Diociaiuti, A., and Teruzzi, C.
- Published
- 2014
- Full Text
- View/download PDF
87. Herpetic Whitlow as a Harbinger of Pediatric HIV-1 Infection
- Author
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El Hachem, M., primary, Bernardi, S., additional, Giraldi, L., additional, Diociaiuti, A., additional, Palma, P., additional, and Castelli-Gattinara, G., additional
- Published
- 2005
- Full Text
- View/download PDF
88. Association of Intermediate Osteopetrosis with Poikiloderma
- Author
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Migliaccio, S., primary, Luciani, M., additional, Taranta, A., additional, De Rossi, G., additional, Minisola, S., additional, El Hachem, M., additional, Bosman, C., additional, De Felice, L., additional, Boldrini, R., additional, Corsi, A., additional, Bianco, P., additional, and Teti, A., additional
- Published
- 1999
- Full Text
- View/download PDF
89. Mucocutaneous manifestations in children with HIV infection and AIDS.
- Author
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El Hachem, M, primary, Bernardi, S, additional, Pianosi, G, additional, Krzysztofiak, A, additional, Livadiotti, S, additional, and Gattinara, GC, additional
- Published
- 1998
- Full Text
- View/download PDF
90. LAMB3 gene mutations in a patient with herlitz junctional epidermolysis bullosa displaying immunoreactivity to laminin-5
- Author
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Posteraro, P., primary, El Hachem, M., additional, Cicuzza, S., additional, Meneguzzi, G., additional, Zambruno, G., additional, and Castiglia, D., additional
- Published
- 1998
- Full Text
- View/download PDF
91. Cutaneous manifestations in 143 immunocompromised children
- Author
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El Hachem, M, primary
- Published
- 1995
- Full Text
- View/download PDF
92. Acral skin atrophy in an infant: an early clue to Kindler syndrome diagnosis.
- Author
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Diociaiuti, A., Zambruno, G., Giancristoforo, S., Proto, V., Boldrini, R., Castiglia, D., and El Hachem, M.
- Subjects
IMMUNOFLUORESCENCE ,SKIN biopsy ,DERMIS ,ATROPHY - Abstract
The article presents a case study of a 3-month-old male infant with the epidermolysis bullosa (EB). His immunofluorescence examination of a skin biopsy revealed a patchy, reticular labelling extending from the cutaneous basement membrane zone (BMZ) to the papillary dermis. The article discusses the Kindler syndrome (KS) with skin atrophy.
- Published
- 2016
- Full Text
- View/download PDF
93. Teledermatology diagnosis of the first Italian patient affected with restrictive dermopathy due to ZMPSTE24 homozygous mutation.
- Author
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Diociaiuti, A., D'Amico, P., Pisaneschi, E., Giancristoforo, S., Pappalardo, M.G., Di Guardo, V., Zambruno, G., and El Hachem, M.
- Subjects
FETAL growth retardation ,DIAGNOSIS - Published
- 2019
- Full Text
- View/download PDF
94. Autosomal recessive epidermolysis bullosa simplex due to <italic>KRT14</italic> mutation: two large Palestinian families and literature review.
- Author
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Diociaiuti, A., El Hachem, M., Castiglia, D., Naim, M., Condorelli, A. G., and Zambruno, G.
- Subjects
- *
NEVUS , *MELANOMA , *DERMIS , *PERIODIC health examinations - Abstract
The article presents a case study of a 24-year-old white female with congenital skin lesion. It is noted that these lesions were identified as blue nevus, which is an acquired melanocytic lesion characterized by a proliferation within the reticular dermis of dendritic and spindled melanocytes. The article adds that longâ€term monitoring of patients with PTBN is required and surgical removal of such lesions should be considered, especially in the presence of any case of enlargement or change.
- Published
- 2018
- Full Text
- View/download PDF
95. Novel <italic>PNPLA1</italic> mutations in two Italian siblings with autosomal recessive congenital ichthyosis.
- Author
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Diociaiuti, A., Pisaneschi, E., Zambruno, G., Angioni, A., Novelli, A., Boldrini, R., and El Hachem, M.
- Subjects
ICHTHYOSIS ,CONGENITAL ichthyosiform erythroderma ,SKIN biopsy ,EPIDERMOLYTIC hyperkeratosis ,GENETIC mutation ,CONGENITAL disorders - Abstract
The article discusses novel PNPLA1 mutations in two Italian siblings with autosomal recessive congenital ichthyosis. Their skin biopsy showed compact hyperkeratosis with focal parakeratosis, follicular plugging and mild acanthosis alongwith perivascular inflammatory infiltrates. It also reports that variant and ultrastructural analysis confirmed the presence in the upper epidermal layers.
- Published
- 2018
- Full Text
- View/download PDF
96. Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra.
- Author
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Oranges, T., Insalaco, A., Diociaiuti, A., Carnevale, C., Strippoli, R., Zambruno, G., Tomà, P., and El Hachem, M.
- Subjects
ISOTRETINOIN - Published
- 2017
- Full Text
- View/download PDF
97. Multidisciplinary approach,Approccio multidisciplinare
- Author
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Bartuli, A., Bertini, E., Callea, F., Cappa, M., Caviglia, S., D Argenio, P., fabrizio De Benedetti, Digilio, M. C., Dionisi Vici, C., El Hachem, M., Emma, F., Nobili, V., Pagnotta, G., and Vignati, E.
98. Multidisciplinary approach | Approccio multidisciplinare
- Author
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Bartuli, A., Bertini, E., Callea, F., MARCO CAPPA, Caviglia, S., D Argenio, P., Benedetti, F., Digilio, M. C., Dionisi Vici, C., El Hachem, M., Emma, F., Nobili, V., Pagnotta, G., and Vignati, E.
99. Antiinflammatory therapy with canakinumab for atherosclerotic disease
- Author
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Ridker P.M., Everett B.M., Thuren T., MacFadyen J.G., Chang W.H., Ballantyne C., Fonseca F., Nicolau J., Koenig W., Anker S.D., Kastelein J.J.P., Cornel J.H., Pais P., Pella D., Genest J., Cifkova R., Lorenzatti A., Forster T., Kobalava Z., Vida-Simiti L., Flather M., Shimokawa H., Ogawa H., Dellborg M., Rossi P.R.F., Troquay R.P.T., Libby P., Glynn R.J., Krum H., Varigos J., Siostrzonek P., Sinnaeve P., Gotcheva N., Yong H., Urina-Triana M., Milicic D., Vettus R., Manolis A.J., Wyss F., Sigurdsson A., Fucili A., Veze I., Petrauskiene B., Salvador L., Klemsdal T.O., Medina F., Budaj A., Otasevic P., Lainscak M., Seung K.B., Commerford P., Donath M., Hwang J.J., Kultursay H., Bilazarian S., East C., Forgosh L., Harris B., Ligueros M., Bohula E., Charmarthi B., Cheng S., Chou S., Danik J., McMahon G., Maron B., Ning M., Olenchock B., Pande R., Perlstein T., Pradhan A., Rost N., Singhal A., Taqueti V., Wei N., Burris H., Cioffi A., Dalseg A.M., Ghosh N., Gralow J., Mayer T., Rugo H., Fowler V., Limaye A.P., Cosgrove S., Levine D., Lopes R., Scott J., Hilkert R., Tamesby G., Mickel C., Manning B., Woelcke J., Tan M., Manfreda S., Ponce T., Kam J., Saini R., Banker K., Salko T., Nandy P., Tawfik R., O’Neil G., Manne S., Jirvankar P., Lal S., Nema D., Jose J., Collins R., Bailey K., Blumenthal R., Colhoun H., Gersh B., Abreu M., Actis M.V., Aiub J., Aiub F., Albisu J., Alvarisqueta A., Avalos V., Barreto M., Berli M.A., Blumberg C., Bocanera M., Botta C., Bowen L., Budassi N., Buhlman S., Westberg J.C., Carabajal T., Caruso G., Casala J., Cendali G., Coloma G., Berra F.C., Cuneo C., Degennaro N., Dellasa M., Diaz M., Dos Santos P., Espinosa V., Facello A., Facello M., Farias E., Fernandez A.A., Ferrari V., Pacora F.F., Flores G.S., Franco M., Gabito A., Viola H.G., Garcia F., Garcia Duran R., Garcia Pinna J., Glenny J., Godoy Sanchez M., Grosse A., Guzman P., Hasbani E., Hominal M., Ibañez J., Jure H., Jure D., Vico M.L., Liniado G., Luciardi H., Luquez H., Maehara G., Maffei L., Majul C., Mallagray M., Marinaro S., Martinez J., Massaccesi R., De Los Milagros Had M., Azize G.M., Montana O., Montenegro E., Morell Y., Muntaner J., Navarrete S., Olmedo M., Paganini M., Paz S., Perez Manghi F., Piskorz D., Polato C., Recoaro R., Romano A., Salinger M., Sanchez A., Saravia M.A., Sarjanovich R., Scaro G., Schiavi L.B., Soler J., Tinnirello V., Tomassi A., Valle M., Vallejo M.A., Venturini C., Marcela Wenetz L.M., Yossen M., Zaidman C., Zalazar L., Zangroniz P., Amerena J., Brady L., Colquhoun D., Eccleston D., Ferreira-Jardim A., French J., Jayasinghe R., Mcintosh C., Ord M., Plotz M., Purnell P., Roberts-Thomson P., Schultz C., Shanahan T., Tan R., Taverner P., Turner F., Vibert J., Vorster M., William M., Youssef G., Bergler-Klein J., Brath H., Brodmann M., Fliesser-Goerzer E., Haider K., Heeren G., Hiden C., Mandic L., Paulweber B., Ploechl A., Prenner A., Steringer-Mascherbauer R., Strohner-Kaestenbauer H., Barbato E., Bouvy C., Briké C., Charlier F., Cools F., De Knijf K., De Wolf L., Delforge M., Deweerdt N., Gits F., Goffinet C., Hermans K., Hollanders G., Mestdagh I., Pirenne B., Servaes V., Simons N., Tahon S., Theunissen E., Van Genechten G., Vervoort G., Vissers C., Vranckx P., Vrolix M., Abib E.Jr., Abrantes J., Araujo Fonseca M., Barbosa E., Barroso W., Barroso A., Bodanese L., Botelho R., Costa Amorim R., Da Costa F., Da Silva A., Da Silva O.Jr., Da Silva D.Jr., Ferreira Dos Santos T., Dos Santos F., Dos Santos A., Duda N., Feitosa G., Felario Junior GA., Ferraz R., Filho P., Fonseca A., Wanderley F.F., Freitas E., Fucci F., Marengo Garcia De Carvalho L., Hernandez M., Hettwer Magedanz E., Julião K., Kormann A., Lameira A., Lima F., Lino E., Maia L., Manenti E., Marchi A.L., Fischer S.M., Michalaros Y., Moraes J.Jr., Moreira L., Pagnan M., Pesce F., Pinheiro L., Rassi S., Reis G., Reis H., Resende I., Roel A., Ruschel K., Saporito W., Saraiva J.F., Seroqui M., Silva R., Unterkircher B., Vicente C., Vieira N., Xavier J.P., Zucchetti C., Angelova I., Dimitrov G., Genova D., Gospodinov K., Goudev A., Grigorova V., Hristova K., Makedonska J.J., Katova T., Kostov K., Lazov P., Manov E., Manukov I., Manukov D., Milanova M., Kabakchieva V.M., Petrov D., Petrusheva T., Pramatarova I., Raev D., Runev N., Sirakova-Taseva A., Tisheva-Gospodinova S., Todorova A., Tzekova M., Yakovova S., Yanev T., Abulencia K., Arora S., Baker A., Bata I.R., Beaudry M., Belle Isle J., Bilodeau N., Boivin M.C., Bolduc H., Bourgeois S., Brons S., Cantor W., Chaussé I., Chhabra A., Chouinard G., Cleveland T., Dattani D., Deslongchamps F., Diodati J., Drouin K., Duchesne L., Fontaine S., D'Amours D.G., Gervais B., Gosselin G., Graham J., Grover A., Gupta A., Haldane H., Hartleib M., Hickey L., Huynh T., Johnston J., Julien V.E., Lachance P., Lake J., Lamontagne C., Lauzon C., Lepage S., Maheux K., Manyari D., Martin E., McPherson C., Mehta S., Michaud N., Kouz S.M., Murphy G., OKeefe D., Otis R., Ouimet F., Pandey S., Peck C., Perkins L., Richert L., Robbins K., Robinson S., Cabau J.R., Ross B., Roy C., Roy M., Roy A., Rupka D., Affaki G.S., Saunders K., Savard D., Soucy D., St Amour E., Thiessen S., Vertes G., Vezina M., Vincelli G., Weisnagel S.J., Zadra R., Chen J., Chen Y., Dong X., Feng Y., Feng Z., Fu G., Han B., Hao Y., He Y., He Z., Hong T., Jia Z., Jiang T., Jiang J., Jiang X., Ke Y., Li Y., Li Z., Li W., Li X., Liu P., Liu Y., Liu B., Liu S., Liu L., Lu Z., Lv Y., Ma C., Ma G., Peng L., Qing L., Ren L., Sang X., Song M., Sun Z., Wang J., Wang Y., Wei J., Wu W., Wu J., Xu H., Yan J., Yang P., Yang K., Yao Z., Yaoqing H., Yuan Z., Zhai Z., Zhang J., Zhang Y., Zhao R., Zhou H., Accini Mendoza JL., Aparicio C.V., Castillo T., Chaverra I., Conrado Y., Coronel J., Cotes C., Cuentas I., Cuervo A., Dussan M.A., Echeverria L., Hernandez E., Ibarra J., Isaza D., Jimenez D., Lopez P., Manzur F., Mejia I., Mendoza Y., Molina D.I., Patino J.M., Rodriguez D., Rodriguez L.M., Rodriguez S.M., Sanchez Vallejo G., Luz Serrano H., Sotomayor A., Urina M., Vesga B., Yupanqui H., Akrap B., Busic N., Ciglenecki N., Cmrecnjak J., Fucak E., Gabor M., Jeric M., Jutrisa N., Kordic K., Planinc I., Popovic Z., Radeljic V., Sesto I., Sutalo K., Tusek S., Belohlavek J., Budkova J., Busak L., Capova L., Cech V., Cermak O., Coufalova Z., Cyprian R., Dedek V., Dedkova S., Ferkl R., Hanak P., Hanustiakova A., Homza M., Horackova K., Houra M., Iveta H., Kaiserova L., Kala P., Karel I., Kellnerova I., Koleckar P., Kreckova M., Krupicka J., Lorenc Z., Machova V., Malik J., Masarikova L., Matyasek I., Mikus M., Mikusova T., Ondrasik J., Otava M., Palubova L., Pavlickova L., Peterka M., Petrova I., Pokorna B., Povolny P., Radvan M., Reznakova S., Rickova Z., Roszkowska P., Rotreklova M., Samkova D., Skalicka H., Slechticka A., Sternthal P., Telekes P., Tesak M., Vesely P., Vesely J., Vins P., Vitovec M., Vodnansky P., Zidova M., Keba E., Laane E., Pool T., Randvee L., Ratnik E., Reimand M., Reinmets S., Rivis L., Siemann M., Stern M., Toom M., Vahula V., Apel T., Axthelm C., Ayasse D., Ayasse M., Baar M., Baeumer A., Bagi E.S., Becker B., Binder A., Blankenberg S., Braun P., Johansen B.B., Contzen C., Delfonso F., Denecke C., Dengler T., Donaubauer T., Eichinger G., Englmann E., Erhard M., Faghih M., Foerster A., Frankenstein L., Fuchs R., Furch G., Gaeb-Strasas B., Germann H., Giese C., Goette A., Gravenhorst-Muenter U., Haege R., Haenel T., Hagemann D., Hagenow A., Hanefeld M., Heider J., Heisters J., Hennig D., Hielscher S., Himpel-Boenninghoff A., Holscher A., Hornig M., Jeserich M., Kaczmarek N., Kanitz S., Kara Y.D., Khariouzov A., Kiefer R., Kiroglu K., Klamm M., Klein C., Korth-Wiemann B., Krapivsky A., Kuenzler J., Kuntzsch A., Landers B., Lappo M., Laube S., Leggewie S., Lehmann D., Lepp H., Lierse T., Lindner C., Luecke-Uzar M., Luedemann J., Marschke T., Maruzzo S., Mauersberger K., Maus O., Meinrich M., Meissner A., Moehring B., Muehlhaus J., Mueller S., Muenter K.C., Muenzel T., Naumann R., Nebel J., Neumann J., Nuding S., Overhoff U., Papke B., Pencz I., Peter Y., Peukert A.M., Radde I., Rau T., Regner S., Reichenbach D., Reimer D., Rinke A., Roettges R., Romanski A., Rummel R., Samer H., Sanuri M., Sarnighausen H.E., Schäfer B., Scheibner T., Schermaul K.H., Schindler A., Schlundt C., Schmidt E., Schmidt K., Schnabel A., Schoen N., Schorn K., Schroeder T., Schulenburg D., Schulz M., Schulze U., Schulze J., Schumacher M., Schwerin G., Schwerin M., Stadelmeier S., Stahl H.D., Stahl A., Stockhausen J., Stockhausen G., Stoessel J., Stolze K., Stratmann M., Szymanowski N., Teschner A.B., Teske A., Uecker C., Veit S., Voeller H., Walter I., Walter J., Walther I., Weber H.G., Weimer J., Wichterich K., Wiebusch A., Willmerdinger M., Willner C., Winkelmann B., Winkler J., Wistuba T., Woehrle J., Wohnlich T., Wolf S., Woyczak D., Wrage P., Zirlik A., Anadiotis A., Chachalis G., Dermitzakis A., Kafarakis P., Kaldara E., Kolokathis F., Kostakou P., Lekakis J., Manolis A., Mantas I., Megalou A., Milkas A., Nanas J., Olympios C.D., Patsilinakos S., Perperis A., Poulimenos L., Saloustros I., Tsioufis K., Tsorbatzoglou K., Vardas P., Zarifis I., Aguilar M., Arango J.L., Borrayo N.A., Corona V., Guerrero A., Guzman I., Haase F., De Krumbach L., Montenegro P., Munoz R., Munoz N., Paniagua A., Solares A., Vogel M., Anita S., Blazsek Z., Decsi K., Fulop T., Hangyal T., Hegedus V., Kalina A., Karakai H., Katona A., Kiss R.G., Kovacs A., Laszlo Z., Lupkovics G., Medvegy M., Merkely B., Mihaly N., Nagy A.C., Dékány J.N., Nikoletta P., Noori E., Penzes J., Poor F., Sarszegi Z., Simay A., Simon J., Szakal I., Szatmarine V., Szocs A., Zilahi Z., Karsai X.Z., Andersen K., Sigurdadottir E., Skuladottir F., Abdullakutty J., Abhaichand R., Abhyankar A., Agarwal D.K., Aggarwal R.K., Ahire N., Awasthi A.K., Babu R., Bai A., Bali H.K., Banker D., Bhadade S., Bisne V., Bohra P., Raghu C., Chauhan D., Chauhan H., Chavada J., Chaware G., Chella S., Chintala P., Dash D., Desai D., Devasia T., Dhanak R., Dobariya H., Dudhatra N., Duhan S., Fulwani M., Ghondale N., Ghosh S., Gohel P., Govindaraj D., Goyal B., Goyal S., Gundala A.K., Gupta M., Hardas S., Iby M., Jagtap P., Jain A., Joshi U., Karpuram M., Kaur H., Khan A., Khan R., Kodem D.R., Koeitti P., Kulkarni L., Kullal P., Kumar K.S., Kumbla M., Latheef K., Lohkare M., Santosh M.J., Makhe B., Mandati M., Mehta A., Minocha G., Mittal A., Modi R., Mohan K., Oomman A., Pai R., Pai V., Palaniswami N., Pansheriya A., Parekh N., Patel J., Patel R., Patole T., Praveen M., Radhakrishnan V., Rajan B A., Rajasekhar D., Rao M., Rao M.B., Rao N.M., Rathnavel S., Rathore A., Rathore SRS., Rawat S., Reddy N.C., Sarma R., Sathe S., Shah J., Shaikh P., Sharma K., Sharma S., Sharma T., Shetty P., Sidhu G., Singh V., Sohi G.S., Srinath V.S., Raju S.S., Taran A., Thakkar B., Velusamy K., Vijan V., Vora V., Vuriya A.K., Agosta G.F., Antonicelli R., Ardissino D., Argiolas G., Baldin M.G., Benedetti G., Berti S., Bevilacqua M.T., Bolognesi M.G., Dessalvi C.C., Calabrese A., Campanale E.G., Candusso R., Caso P., Cosmi F., Crea F., Crocamo A., De Caterina R., De Rosa S., Destro M., Di Biase M., Dognini G.P., Eleuteri E., Fedele F., Ferrario M., Gabrielli D., Gamba C., Ganau A., Gravellone M., Iannopollo G., Indolfi C., Infusino F., Invitti C., Landolfi A., Lembo G., Liberato N.L., Mannucci E., Marino P., Mariottoni B., Marziali A., Mercuro G., Monti L., Mos L., Mureddu V., Musumeci M.B., Novo S., Panzarino C., Parente A., Perotti M., Filardi P.P., Petrillo C., Piatti P., Priori S., Racca V., Ragghianti B., Renda G., Righini V., Sarcone M., Senni M., Soro E., Tamburrini P., Vallone L., Villani G.Q., Volpe M., Ajioka M., Akai Y., Ashino K., Baden M., Doi M., Eki Y., Endo T., Fukuike C., Hagiwara Y., Hasegawa K., Higuchi Y., Higuchi T., Hioki M., Hirayama A., Hiroma J., Hosokawa S., Ichisawa M., Iijima T., Inada T., Inagaki M., Ito K., Kaigawa K., Kajihara S., Kamiya H., Kamiya J., Kaneno Y., Katahira K., Kataoka M., Kawai M., Kawasaki T., Kojima E., Komura Y., Kuramochi T., Kuruma T., Kyo E., Mani H., Miyamoto T., Morii I., Morinaga Y., Morisawa T., Nagai Y., Naka T., Nakamura Y., Nakamura S., Nakayoshi K., Nishibe A., Ogawa M., Okada Y., Okawa M., Sakamoto Y., Sakurada M., Sasaki S., Seki S., Shimomura H., Shinozaki T., Sugimoto N., Suzuki A., Taguchi S., Takahashi J., Takase S., Tanabe K., Tanaka A., Tani S., Tomioka J., Tsuboi H., Tsuji M., Tsujita K., Tsujiyama S., Umesu A., Yamada T., Yamaguchi E., Yamamoto H., Yamamoto T., Yamane M., Yanase T., Yasuoka S., Yasutake M., Yokoyama M., Yoshida M., Yoshimoto E., Yunoki C., Balode A., Dormidontova G., Flaksa I., Nagele-Luse I., Rancane G., Sime I., Bartuseviciene S., Cepinskiene L., Dobilas V., Grigaraviciene I., Marcinkeviciene J., Mazutavicius R., Miliuniene R., Motiejuniene R., Norkiene S., Norkute-Macijauske U., Rudys A., Slapikas R., Stonkute K., Strazdiene D., Tijuneliene E., Urbonas G., Vanagiene S., Viezelis M., Arenas Leon JL., Bayram E., Carrillo J., Davalos C., De Los Rios M., Delgadillo T., Hernández N., Leon S., Mendoza N., Muñoz W., Ramos G., Anneveldt A., Bakker H., Brouwer M., Bunschoten P., De Boer P., De Jong C., De Vos A., Den Hartog F., Doesborg L., Dommerholt R., Drost I., Ellenbroek D., Engelen W., Folkeringa R.J., Hamer BJB., Herrman J.P., Hoogslag PAM., Jansen M., Jerzewski A., Joosten C., Kalkman C., Kietselaer B., Kok M., Kooiman E., Kose V., Lardinois R., Lenderink T., Lok DJA., Lousberg A., Meijlis P., Mulder R., Singerling M., Smeele F., Stroes E., Swart H.P., Ten Holt W., Van Der Wal M., Van Der Zwaan C., Van Kempen W.W., Van Maarseveen M., Van Stein I., Viergever E.P., Visseren FLJ., Voors C., Nugteren SKZ., Ata B., Berulfsen A., Rønnevik T.D., Dickstein K., Furuseth B., Grundtvig M., Hansen H., Hofsoey K., Høivik H.O., Bøen R.H., Hurtig U., Pettersen K.I., Johansen E., Kleve R., Kolleroy C., Moen S., Nilsen V., Norin V., Otterstad J.E., Risberg K., Rønnevik P., Sirnes P.A., Skjelvan G., Strand S., Szacinski G., Vegsundvåg J., Alcalde J.M., Gomez Sanchez J., Rodriguez J., Rodriguez A., Zena N., Baszak J., Cymerman K., Czerski T., Fratczak M., Jaguszewska G., Kawka-Urbanek T., Koba M., Kopaczewski J., Kopczyńska M., Laniec M., Lysek R., Sciborski R., Szpajer M., Torun A., Wujkowski M., Zielinski M., Ahn Y., Baek C., Bang S.A., Chang K., Choi A.J., Han S., Hyun K., Kim M., Kim K.S., Kim B., Lee S.H., Lee J., Lee H.N., Lee J.H., Moon K., Park B., Park C., Tahk S., Yim K.H., Yim S., Tase T., Andor M., Aron G., Badea C., Casoinic F., Clocotan M., Coman S., Emil B., Imre B.S., Istratoaie O., Liviu C., Maximov D., Militaru C., Minescu B., Istvan K.P., Parepa I., Petrescu L., Podoleanu C., Pop C.F., Popa V., Popescu E., Radoi M., Sarbu I., Socoteanu E., Socoteanu G., Sorodoc L., Spiridon M., Stanciulescu G., Stefanescu M., Tanaseanu C., Tudoran M., Zdrenghea D., Agafina A., Akatova E., Avdonina N., Balukova E., Barbarash O.L., Bartosh L., Boyarkin M., Bulashova O., Burova N., Churina S., Demidova M., Dorogova I., Dovgalevskiy Y., Dovgolis S., Dudarev M., Fitilev S., Gapon L., Gazizianova V., Gordeev I., Ivanov I., Izmozherova N., Kazanskay E., Khirmanov V., Khromtsova O., Konradi A., Kosmacheva E., Kozlova S., Kulibaba E., Kuzin A., Libov I., Lipchenko A., Lozhkina N., Malchikova S., Morozov E., Myslyaeva L., Onuchina E., Palatkina T., Panov A., Parmon E., Petelina T., Repin A., Reznik I., Sazonova E., Sergienko T., Shaposhnik I., Shapovalova Y., Shustov S., Shvarts Y., Skopets I., Skuratova M., Smolenskaya O., Solovev O., Trofimov V., Vasiliev M., Vezikova N., Vozzhaev A., Yakushin S., Zadionchenko V., Apostolovic S., Adjic N.C., Ilic I., Ilic S., Nikolic L., Pupic L., Stokuca-Korac N., Antalik L., Bugan V., Csala L., Dokupilova A., Dzupina A., Forgon T., Fulop P., Gonsorcik J., Gyorgyova E., Holoubek D., Horvat P., Kamensky G., Kolikova V., Krupciakova B., Lenner E., Lennerova J., Lukac J., Majercak I., Mancikova I., Micko K., Nociar J., Pales J., Palka J.Jr., Poliacik P., Ruffini L., Sabo L., Skubova K., Slanina M., Smik R., Srdos V., Stitova M., Stofkova D., Strbova J., Such S., Toth P., Urgeova L., Vinanska D., Zareczky P., Flezar M., Kovacic D., Marcun R., Zagozen P., Bolsmann C., Conradie C., Dawood S.Y., Decsi K.L., Ebrahim I., Henley L., Horak A., Kapp I., Komati S., Lock E., Maboyi S., Makotoko E., Manga P., Page A., Ramdas S., Ranjith N., Roos J., Talliard C., Ajax K., Al-Khalili F., Assarsson E., Bergholtz T., Blom K.B., Boman K., Boström P.A., Curiac D., Jensen E.D., Dahlen G., Davidsson K., Duckert A., Hansson A., Härstedt N., Henriksson A., Olsson G.H., Johansson K., Jonsson J.E., Knutsson A., Lindholm C.J., Lönnberg I., Lundqvist M., Mellberg L., Moodh J., Mooe T., Olofsson M., Risenfors M., Rönndahl M., Sundelin R., Suorra I., Torgersruud M., Torstensson I., Chen C.P., Chen Z.C., Chen M.H., Cheng S.M., Cheng J.J., Fang C.Y., Ho C.J., Hsieh I.C., Huang P.H., Huang A., Kuo J.Y., Lai W.T., Lee S.C., Lin T., Liu H.M., Tsai M.C., Tsao H.M., Tzong L., Ueng K.C., Wang Y.L., Wang H.C., Wang C.P., Yang C.C., Abaci F., Birdane A., Yilmaz M.B., Asim Oktay AO., Kan G., Koldas N., Ozcan I.T., Sahin M., Sahin T., Saka B., Tekten T., Ucar N., Uresin S., Yigit Z., Arif I., Bakhai A., Baksi A., Blagdon M., Brickman T., Brown N., Burton M., Burton J., Chaggar S., Chung A., Collier D., Covell W., Crawford G., Davies N., Davies M., Dayer M., Doughty A., Duff J., Dwenger E., Fisher J., Fitzpatrick L., Garner K., Glover J., Haughton G., Ilsley M., Ivan P., Voyzey E.J., Keenan S., Kelt T., Knight J., Kondagunta V., Lang C., Lee K., Lim L., Macdonald J., Mathew A., Mckenzie A., Mckibbin A., Michalska A., Pagett K., Pogson A., Price R., Price D., Procter K., Pye M., Redfearn H., Rewbury J., Ryding A., Sattar N., Sharp A., Shaw P., Simpson H., Smith W., Squire I., Storey R., Teenan M., Thomas H., Townend J., Trevelyan J., Wakeling J., Walukiewicz P., Wilkinson S., Zaman A., Acevedo L., Benton J., 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W., Caballero-Valiente B., Carr K., Halliwell T.C., Castillo J., Cei L., Cerda L., Chambers J., Chamblee T., Chattin W., Chee L., Chen Y.C., Cherlin R., Cheung D., Chiodi L., Christensen L., Christenson S., Cislowski D., Clavier-Firmin C., Colfer H., Colvin T., Cosgrove N., Covert C., Cox B., Cox R., Craig W., Crandall L., Crepps K., Cromer M., Cruz H., Cruz M., Cucher F., Damron M., Dave K., Dave B., Davis M., Davis B., Dawkins-Hughes S., Dean J., Debnam S., Defosse C., Dehning M., Dela Llana A., Dellorso M., Denham D., Desalle D., Dettmer M., Dhawan M., Diago M., Dicken T., Diederich C., Diederich M., Diehl R., Digangi D., Diller P., Dimattia M., Dodds G., Doggett J., Donahue K., Doughty L., Dragutksy B., Dreese M., Dunhurst F., Dunn D., Dutka C., Earl J., Eaton C., Eaves W., Ebeling K., Eder F., Edgerton L., Edillo C., Edwards J., Edwards T., Einhorn D., El Hafi S., Ellis M., Erickson B., Ervin W., Eskridge L., Fail P., Falcon D., Fang C., Fattal P., Fawson A., Felix L., Ferdinand K., Fien E., Fintel D., Firek C., Fitz-Patrick D., Flores E., Flores H., Floro T., Forker A., Foster M., Foucauld J., Lehman K.F., Fox B., Francoeur L., Frandsen B., Frivold G., Fruchter G., Fullerton D., Gabriel J., Gacioch G., Garas S., Garcia N., Garcia Rinaldi R., Garcia-Fragoso V., Garcia-Portela M., Gelb R., George F., Ghali J., Gilbert J., Gilley J., Glancy R., Goff R., Goldberg N., Gonzales D., Gonzales V., Gonzalez E., Gorges R., Gould R., Grabeau R., Grable M., Graham J.A., Graif J., Green E., Greener R., Greenway F., Grieshaber V., Griffin S., Gros C., Gudipati RVC., Guillinta P., Gupta V., Gutmann J., Gwyn M., El Hachem M., Hage F., Hageman T., Haidar A., Hakas J., Haldis T., Hall L., Hall C., Hall S., Halpern S., Hamud-Socoro A., Hardee L., Harrell W., Harrington A., Hartwell J., Hasan F., Hattler B., Haught H., Haynes E., Haywood A., Heaney L., Hecht J., Hernandez I., Herzog W., Hess E., Hill H., Hilton T., Hinderaker P., Hodnett P., Hoffman M., Hogan C., Holmes Z., Rees D.H., Hotchkiss D., Huang P., Humbert J., Hutchens E., Iachini K., Ibarra M., Igbokidi O., Ilahi T., Imbrognio M., Ipp E., Iteld B., Jacques G., Jafri A., Jafry B., Jardula M., Jefferson D., Jenkins R., Johnson E., Johnson J., Jones S., Kawahara M., Kelehan S., Kelly R., Kendall T., Kereiakes D., Khan M., Khan S., Kick J., Kimmel M., King T., King A., Kirkland S., Kissel S., Kitchens D., Klein P., Klugherz B., Korban E., Koren M., Korte M., Kostis J., Kotek L., Kozak M., Kreutter F., Kusnick B., Labovitz R., Lail J., Lamance J., Lamas G., Lambert J., Lambert C., Landzberg J., Langdon J., Lavoie W., Ledger G., Lee T., Lehman R., Leimbach W., Lennard M., Lepor N., Lester F., Levin P., Levinson L., Lewis D., Lillo J., Link L., Long C., Longaker R., Lorch G., Lucksinger G., Lynd S., Rhudy J.M., Madder R., Magness K., Maheshwari A., Alan A., Malek M., Maletz L., Malhotra V., Malhotra S., Mandviwala M., Mani C.K., Manuel J., Marchelletta N., Marshall L., Marsters M., Martin L., Martinez E., Mavromatis K., Maynard R., Mays M., Mays B., Mbulaiteye A., Mcalister R., Mccoy C., Mccrary D.Jr., Mccullough-O'Brien H., Mcdonald M., Mcgill J., Mcgrew F., Mckenzie C., Mclaurin B., Mclellan B.A., Mcneil D., Mcneill R., Mehrle A., Melbie K., Melliza T., Messina T., Meyer R., Michel K., Mikdadi G., Miller C., Miller R., Miller A., Miller G., Miller W., Mitchell J., Moats DJR., Mody F., Moffat J., Molk B., Molter D., Monroe T., Montero H., Montgomery R., Mookherjee D., Moran J., Moriarty P., Morrison J., Morton D., Moshayedi P., Mosley J., Moustafa M., Munshi K., Murray A., Mustafa J., Nadar V., Naidu R., Nalley J., Navy S., Neil L., Neutel J.M., Niblack P., Nicely V., Nicolai M., Nijmeh G., Nikas A., Nikyar A., Nixon S., Norman L., Noto G., Nour K., Nugent A., Ocman B., Odegard A., Olsen S., Ortiz-Carrasquillo R., Ossino N., Paez H., Palchick B., Paliwal Y., Pannell R., Parfait V., Partridge J., Patel B., Patel M., Patel S., Paysor C., Pena A., Pereira S., Perez M., Perez A., Perkins H., Perry B., Peters P., Phillippi C., Phillips A., Piacente R., Pintado M., Pish R., Pitt W., Poling T., Pomposini D., Poock J., Potts J., Poudrier R., Prior J., Pritchard C., Purighalla R., Quddusi K., Quinones J., Quinton D., Radin M., Radojcsics B., Rajput B., Rama B., Ramos M., Rauch R., Raynes K., Reber A.M., Reddy J., Reeves M., Reilly K., Renaud K., Resnick H., Reyes R., Richardson M., Riethof M., Riser J., Rodero M., Rodriguez Araya E., Roper L., Rozeman P., Ruder D., Runquist L., Sack G., Saint-Jacques H., Salfity M., Sall N., Sam K., Samal A., Sanchez D., Santiago J.Jr., Savignano C., Saylor R., Scheffel M., Schifferdecker B., Schindler E., Schneider P., Schneider R., Schnitzler R., Schrager B., Schwartz A., Scott R., Seals A., Shah A.V., Shah A., Shatsky K., Shayani S., Shealy N., Sheets L., Shelley J., Shepard P., Shetty S., Silver K., Simon M., Singh K., Singh N., Sizemore B.C., Skatrud L., Slayton C., Slimak V., Sloane G., Smallwood B., Smith P., Smith M., Smith T., Smith G., Smith B., Smith J., Soca Y., Sofley C., Sopko K., Sosa-Padilla M., Sotolongo R., Sprinkle B., Srivastava S., Starzec M., Steinhoff J., Stelly L., Stinson J., Stoddard M., Stoltz S., Stone B., Stover T., Strain J., Strugatsky S., Stys T., Suleman A., Sullivan P., Tamez W., Tandon N., Teltser M., Terry P.S., Terry K., Tessmar C., Thekkoott D., Thomas D., Thomas D.M., Thompson E., Thompson J., Thornton A., Tjaden T., Tobias C., Topper J., Tran A., Treasure C., Trenkamp P., Trevino M., Tsou L., Tuholske C., Uy W., Vahtel M., Vaid B., Valenzuela M., Vance A., Vandam J., Vanhecke T., Vanness WC III., Vargas R., Vaz S., Vazquez Tanus J., Veerina K., Vega J., Vento A., Vijay N., Voelker F., Vogt E., Vold D., Vora K., Wade R.D., Wadell C., Waksman R., Walker K., Wallace K., Warren M., Washam M., Watson B., Webel R., Wells T., West M., Whitaker J., White J., White C., White A., Wilhoit G., Wilkins M., Willingham K., Wilson S., Wilson V., Wise J., Woodall S., Woods A., Wright J., Xu 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Taqueti V., Wei N., Burris H., Cioffi A., Dalseg A.M., Ghosh N., Gralow J., Mayer T., Rugo H., Fowler V., Limaye A.P., Cosgrove S., Levine D., Lopes R., Scott J., Hilkert R., Tamesby G., Mickel C., Manning B., Woelcke J., Tan M., Manfreda S., Ponce T., Kam J., Saini R., Banker K., Salko T., Nandy P., Tawfik R., O’Neil G., Manne S., Jirvankar P., Lal S., Nema D., Jose J., Collins R., Bailey K., Blumenthal R., Colhoun H., Gersh B., Abreu M., Actis M.V., Aiub J., Aiub F., Albisu J., Alvarisqueta A., Avalos V., Barreto M., Berli M.A., Blumberg C., Bocanera M., Botta C., Bowen L., Budassi N., Buhlman S., Westberg J.C., Carabajal T., Caruso G., Casala J., Cendali G., Coloma G., Berra F.C., Cuneo C., Degennaro N., Dellasa M., Diaz M., Dos Santos P., Espinosa V., Facello A., Facello M., Farias E., Fernandez A.A., Ferrari V., Pacora F.F., Flores G.S., Franco M., Gabito A., Viola H.G., Garcia F., Garcia Duran R., Garcia Pinna J., Glenny J., Godoy Sanchez M., Grosse A., Guzman P., Hasbani E., Hominal M., Ibañez J., Jure H., Jure D., Vico M.L., Liniado G., Luciardi H., Luquez H., Maehara G., Maffei L., Majul C., Mallagray M., Marinaro S., Martinez J., Massaccesi R., De Los Milagros Had M., Azize G.M., Montana O., Montenegro E., Morell Y., Muntaner J., Navarrete S., Olmedo M., Paganini M., Paz S., Perez Manghi F., Piskorz D., Polato C., Recoaro R., Romano A., Salinger M., Sanchez A., Saravia M.A., Sarjanovich R., Scaro G., Schiavi L.B., Soler J., Tinnirello V., Tomassi A., Valle M., Vallejo M.A., Venturini C., Marcela Wenetz L.M., Yossen M., Zaidman C., Zalazar L., Zangroniz P., Amerena J., Brady L., Colquhoun D., Eccleston D., Ferreira-Jardim A., French J., Jayasinghe R., Mcintosh C., Ord M., Plotz M., Purnell P., Roberts-Thomson P., Schultz C., Shanahan T., Tan R., Taverner P., Turner F., Vibert J., Vorster M., William M., Youssef G., Bergler-Klein J., Brath H., Brodmann M., Fliesser-Goerzer E., Haider K., Heeren G., Hiden C., Mandic L., Paulweber B., Ploechl A., Prenner A., Steringer-Mascherbauer R., Strohner-Kaestenbauer H., Barbato E., Bouvy C., Briké C., Charlier F., Cools F., De Knijf K., De Wolf L., Delforge M., Deweerdt N., Gits F., Goffinet C., Hermans K., Hollanders G., Mestdagh I., Pirenne B., Servaes V., Simons N., Tahon S., Theunissen E., Van Genechten G., Vervoort G., Vissers C., Vranckx P., Vrolix M., Abib E.Jr., Abrantes J., Araujo Fonseca M., Barbosa E., Barroso W., Barroso A., Bodanese L., Botelho R., Costa Amorim R., Da Costa F., Da Silva A., Da Silva O.Jr., Da Silva D.Jr., Ferreira Dos Santos T., Dos Santos F., Dos Santos A., Duda N., Feitosa G., Felario Junior GA., Ferraz R., Filho P., Fonseca A., Wanderley F.F., Freitas E., Fucci F., Marengo Garcia De Carvalho L., Hernandez M., Hettwer Magedanz E., Julião K., Kormann A., Lameira A., Lima F., Lino E., Maia L., Manenti E., Marchi A.L., Fischer S.M., Michalaros Y., Moraes J.Jr., Moreira L., Pagnan M., Pesce F., Pinheiro L., Rassi S., Reis G., Reis H., Resende I., Roel A., Ruschel K., Saporito W., Saraiva J.F., Seroqui M., Silva R., Unterkircher B., Vicente C., Vieira N., Xavier J.P., Zucchetti C., Angelova I., Dimitrov G., Genova D., Gospodinov K., Goudev A., Grigorova V., Hristova K., Makedonska J.J., Katova T., Kostov K., Lazov P., Manov E., Manukov I., Manukov D., Milanova M., Kabakchieva V.M., Petrov D., Petrusheva T., Pramatarova I., Raev D., Runev N., Sirakova-Taseva A., Tisheva-Gospodinova S., Todorova A., Tzekova M., Yakovova S., Yanev T., Abulencia K., Arora S., Baker A., Bata I.R., Beaudry M., Belle Isle J., Bilodeau N., Boivin M.C., Bolduc H., Bourgeois S., Brons S., Cantor W., Chaussé I., Chhabra A., Chouinard G., Cleveland T., Dattani D., Deslongchamps F., Diodati J., Drouin K., Duchesne L., Fontaine S., D'Amours D.G., Gervais B., Gosselin G., Graham J., Grover A., Gupta A., Haldane H., Hartleib M., Hickey L., Huynh T., Johnston J., Julien V.E., Lachance P., Lake J., Lamontagne C., Lauzon C., Lepage S., Maheux K., Manyari D., Martin E., McPherson C., Mehta S., Michaud N., Kouz S.M., Murphy G., OKeefe D., Otis R., Ouimet F., Pandey S., Peck C., Perkins L., Richert L., Robbins K., Robinson S., Cabau J.R., Ross B., Roy C., Roy M., Roy A., Rupka D., Affaki G.S., Saunders K., Savard D., Soucy D., St Amour E., Thiessen S., Vertes G., Vezina M., Vincelli G., Weisnagel S.J., Zadra R., Chen J., Chen Y., Dong X., Feng Y., Feng Z., Fu G., Han B., Hao Y., He Y., He Z., Hong T., Jia Z., Jiang T., Jiang J., Jiang X., Ke Y., Li Y., Li Z., Li W., Li X., Liu P., Liu Y., Liu B., Liu S., Liu L., Lu Z., Lv Y., Ma C., Ma G., Peng L., Qing L., Ren L., Sang X., Song M., Sun Z., Wang J., Wang Y., Wei J., Wu W., Wu J., Xu H., Yan J., Yang P., Yang K., Yao Z., Yaoqing H., Yuan Z., Zhai Z., Zhang J., Zhang Y., Zhao R., Zhou H., Accini Mendoza JL., Aparicio C.V., Castillo T., Chaverra I., Conrado Y., Coronel J., Cotes C., Cuentas I., Cuervo A., Dussan M.A., Echeverria L., Hernandez E., Ibarra J., Isaza D., Jimenez D., Lopez P., Manzur F., Mejia I., Mendoza 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Zidova M., Keba E., Laane E., Pool T., Randvee L., Ratnik E., Reimand M., Reinmets S., Rivis L., Siemann M., Stern M., Toom M., Vahula V., Apel T., Axthelm C., Ayasse D., Ayasse M., Baar M., Baeumer A., Bagi E.S., Becker B., Binder A., Blankenberg S., Braun P., Johansen B.B., Contzen C., Delfonso F., Denecke C., Dengler T., Donaubauer T., Eichinger G., Englmann E., Erhard M., Faghih M., Foerster A., Frankenstein L., Fuchs R., Furch G., Gaeb-Strasas B., Germann H., Giese C., Goette A., Gravenhorst-Muenter U., Haege R., Haenel T., Hagemann D., Hagenow A., Hanefeld M., Heider J., Heisters J., Hennig D., Hielscher S., Himpel-Boenninghoff A., Holscher A., Hornig M., Jeserich M., Kaczmarek N., Kanitz S., Kara Y.D., Khariouzov A., Kiefer R., Kiroglu K., Klamm M., Klein C., Korth-Wiemann B., Krapivsky A., Kuenzler J., Kuntzsch A., Landers B., Lappo M., Laube S., Leggewie S., Lehmann D., Lepp H., Lierse T., Lindner C., Luecke-Uzar M., Luedemann J., Marschke T., Maruzzo S., Mauersberger K., Maus 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Willingham K., Wilson S., Wilson V., Wise J., Woodall S., Woods A., Wright J., Xu Z.J., Yarows S., Young A., Younis L., Zarate J., Zebrack J., Zhang W., Zieve F., and Zineldine A.
- Abstract
BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P=0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P=0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83
100. Chapter Patient-generated evidence in Epidermolysis Bullosa (EB): Development of a questionnaire to assess the Quality of Life
- Author
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Pilo, Cinzia, Benedan, Laura, El Hachem, May, Galeone, Carlotta, Mariani, Paolo, and Tadini, Gianluca
- Subjects
Epidermolysis Bullosa ,Patient-centered approach ,Quality of Life ,Pseudo-Delphi ,bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics - Abstract
Epidermolysis Bullosa (EB) is a group of genetic conditions that cause fragile and blistering skin. Although there are different types of EB, which differ in severity, their signs and symptoms overlap. As a result of this disorder, patients face an unbearable burden in their lives, and their Quality of Life (QoL) is negatively affected at every life cycle stage. Nevertheless, the assessment of the quality of life of these patients is scanty. This project aims to develop a patient-centered questionnaire to assess the QoL of EB patients. This tool will be a valid aid for clinicians to understand patients better and identify the areas that need more attention; moreover, it will allow them to follow the patients over time and evaluate the impact of any treatments. The methodological process to develop the questionnaire consisted of two phases: firstly, a critical review of scientific literature was performed; secondly, a pseudo-Delphi study was carried out. A multidisciplinary panel (including patients, caregivers, and clinicians) actively participated in round tables to discuss the main areas of interest. Starting from this initial set of areas and through the repetition of Delphi (up to three rounds), a gradual refinement of the statements was carried out to define a list of items to be included in an easy-to-use but meaningful questionnaire. The final patient-centered questionnaire is thus able to measure the QoL beyond the physical symptoms and the clinical evolution of the disease, encompassing functional autonomy, psycho-emotional state, social relations and the working field.
- Published
- 2021
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