Search

Purpose The purpose of this study was to analyse whether an extended depth of focus (EDOF) monofocal intraocular lens (IOL) (TECNIS Eyhance) provides better intermediate visual acuity (VA) than another monofocal IOL (TECNIS 1-piece) from the same platform. Methods Randomised prospective observational study. Patients who required cataract surgery in both eyes were included. Patients in one group were implanted with Tecnis 1-piece IOL and those in the other group with Eyhance EDOF monofocal IOL. One month after surgery in the second eye, we assessed the corrected intermediate VA (66 cm) and obtained defocus curves. We also explored the correlation of: high-order and spherical aberrations with intermediate VA, pupil size with intermediate VA and age with intermediate VA. Results We analysed 30 patients (60 eyes), 15 patients in the TECNIS 1-piece group and 15 in the Eyhance group. Both groups achieved a far VA of 0.00 logMAR. In contrast, for intermediate vision, VA was better with the Eyhance EDOF monofocal IOLs (0.16 ± 0.12 LogMAR), the difference being statistically significant (p Conclusions The new EDOF monofocal IOL (Eyhance) offers sufficient depth of focus to provide patients with comfortable vision without impairing far vision.

Resumen Objetivo El objetivo de este estudio es analizar si una lente intraocular (LIO) monofocal (TECNIS Eyhance®, Johnson&Johnson Surgical Vision, Inc., Santa Ana, CA) de foco extendido proporciona una mejor agudeza visual (AV) intermedia que otras LIO monofocales (TECNIS 1-pieza®, Johnson&Johnson Surgical Vision, Inc., Santa Ana, CA) de la misma plataforma. Metodos Se realizo un estudio observacional prospectivo y aleatorizado con pacientes que necesitaban cirugia de cataratas en ambos ojos. Un grupo de pacientes recibio el implante con la LIO TECNIS 1-pieza y otro grupo recibio la LIO Eyhance de foco extendido monofocal. Un mes desde la cirugia en el segundo ojo se evaluo la AV intermedia corregida (66 cm) y se obtuvieron las curvas de desenfoque. Tambien se exploro la correlacion de aberraciones de orden elevado y esfericas con AV intermedia, tamano pupilar con AV intermedia y edad con AV intermedia. Resultados El estudio analizo a 30 pacientes (60 ojos), 15 de ellos en el grupo TECNIS 1-pieza y 15 en el grupo Eyhance. Ambos grupos consiguieron una AV lejana de 0,00 logMAR. En contraste, para la vision intermedia la AV fue mejor con las LIO Eyhance de foco extendido monofocal (0,16 ± 0,12 LogMAR), siendo la diferencia estadisticamente significativa (p Conclusiones La nueva LIO monofocal de foco extendido (Eyhance) ofrece suficiente profundidad de foco para proporcionar a los pacientes una vision confortable sin afectar la vision lejana.

The number of devices connected to the Internet is increasing rapidly. This may bring many benefits for individuals, but it also entails risks, since it makes us increasingly dependent on services and applications that can be exposed to a wide variety of threats. There are platforms dedicated to inventorying connected devices and making this information available to any user. Throughout this work, we have developed a software application that makes it easy to query two of the most worldwide used IoT search engines: Shodan and ZoomEye. The main objective of this tool is to facilitate research on the use of these platforms, since it allows obtaining data, comparing the results returned, extracting historical information, and even validating it with the fingerprinting tool Nmap. Finally, some scenarios for the practical use of the application and some lines of future work are presented. La cantidad de dispositivos conectados a Internet aumenta de forma vertiginosa. Este hecho aporta muchos beneficios para las personas, pero también conlleva riesgos, dado que nos hace cada vez más dependientes de servicios y aplicaciones que pueden estar expuestos a muy variadas amenazas. Existen plataformas destinadas a inventariar los dispositivos conectados y poner esta información a disposición de cualquier usuario. En este trabajo se ha realizado una aplicación en forma de prototipo que permite consultar dos de las más utilizadas a nivel mundial, Shodan y ZoomEye. El objetivo principal de esta herramienta es facilitar la investigación sobre el uso de estas plataformas, ya que permite obtener datos, comparar los resultados que devuelven, sacar información histórica e incluso validar de forma pasiva la eficacia de los resultados obtenidos con la herramienta de fingerprinting Nmap. Por último, se presentan algunos escenarios para el uso práctico de la aplicación y algunas líneas de trabajo futuro.

60 p. -- Bibliogr.: p. 26-28 Iktusa, mundu mailan heriotza eta desgaitasun kausa nagusienetariko bat suposatzen duen gaixotasun kardiobaskular bat da. Istripu zerebrobaskular (IZB) terminoarekin ere ezaguna, bizipen estresagarria da paziente, senide zein zaintzailentzat. Izan ere, asaldura sentsorialak, motoreak, komunikazio asaldurak, asaldura kognitibo eta psikotikoak eta portaera asaldurak eragin ditzake. Aipatutako klinikaz gain, iktusaren intzidentzia, prebalentzia, kostu, heriotza eta desgaitasun-tasa altuek IZB osasun eta gizarte-arazo bilakatzen dute. Badaude zenbait gida eta errebisio sistematiko ere, ariketa fisikoaren onurak aztertzen dituztenak errehabilitazio prozesuan zehar iktusa pairatu duten pertsonen sintoma motore eta psikologikoen arintzean. Hori buruan izanik, eta erizainaren rola aztertuz, ikus daiteke erizaintzaren konpetentziaren barruan sartzen dela ariketa fisiko eta iktusaren arteko onura erlazio hori ezagutzea, pazienteen eguneroko bizitzako zainketetan aplikatu ahal izateko. Are gehiago, errebisio kritiko hau baliagarria izan daiteke erizainentzat iktusa pairatu duten pazienteen arreta integrala bermatzeko, hezkuntzaren bidez bizi-estilo osasuntsuak sustatuz, pertsonen osasun emaitzak eta bizi-kalitatea hobetuz eta iktus kasuen errekurrentziak ekidituz.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a multi-organ damage that includes hepatic dysfunction, which has been observed in over 50% of COVID-19 patients. Liver injury in COVID-19 could be attributed to the cytopathic effects, exacerbated immune responses or treatment-associated drug toxicity. Herein we demonstrate that hepatocytes are susceptible to infection in different models: primary hepatocytes derived from humanized angiotensin-converting enzyme-2 mice (hACE2) and primary human hepatocytes. Pseudotyped viral particles expressing the full-length spike of SARS-CoV-2 and recombinant receptor binding domain (RBD) bind to ACE2 expressed by hepatocytes, promoting metabolic reprogramming towards glycolysis but also impaired mitochondrial activity. Human and hACE2 primary hepatocytes, where steatosis and inflammation were induced by methionine and choline deprivation, are more vulnerable to infection. Inhibition of the renin-angiotensin system increases the susceptibility of primary hepatocytes to infection with pseudotyped viral particles. Metformin, a common therapeutic option for hyperglycemia in type 2 diabetes patients known to partially attenuate fatty liver, reduces the infection of human and hACE2 hepatocytes. In summary, we provide evidence that hepatocytes are amenable to infection with SARS-CoV-2 pseudovirus, and we propose that metformin could be a therapeutic option to attenuate infection by SARS-CoV-2 in patients with fatty liver.

Amyloid fibrils and fibril-like structures are currently estimated to represent many different products of several genes in humans and play a key role in many types of proteinopathies, commonly associated with ageing process. They share the mutual feature of aggregation-prone proteins and the building up of molecular-supramolecular structure, such as inter-neuronal plaques in the brain of Alzheimer's Disease (AD) patients, characterized by an extraordinary strength. Noteworthy, this type of structure has been reported in different organisms, in particular in invertebrates. The aim of the current review is to focus on alpha and beta amyloids i.e., SAAs, SAP and APP, elucidating the structure and function of amyloid proteins in invertebrates (such as nematods, annelids, molluscs, insects, ascidians) and highlighting their striking pattern of functional conservation when compared to human amyloid-like fibrils, thus focusing on possible new studies and applications for innovative therapies, particularly for AD, the most common and worldwide type of dementia.

The gang rape known as the “La Manada” case has had an unprecedented social impact in Spain. This research investigates how this case has been dealt with through Twitter by a collective symbolic co...

Mantle cell lymphoma (MCL) is a mature B cell neoplasm with two distinct biological subtypes regarding clinical, molecular and pathological features. Conventional MCL (cMCL) subtype is characterized by high aggressiveness and poor outcome with frequent relapses after initial response to treatment, suggesting the presence of a population of cancer stem cells (CSC) able to self-renew and responsible for drug resistance. SOX11 embryonic transcription factor is aberrantly overexpressed mostly in cMCL and has an oncogenic role in MCL. MCL-CSC have been isolated from MCL cases by different groups. However, its relationship to SOX11 expression and contribution to MCL clinical features and aggressive behavior remains unknown. We hypothesized that SOX11 may promote stem cell-like properties through the activation of stem cell-related genes, leading to an aggressive and incurable tumor in MCL patients. Here, we integrated the differential gene expression profile (GEP) between SOX11+ and SOX11- MCL primary cases with stem cell-related genes, and specific SOX11 ChIP-chip and epigenetic data in MCL cell lines and primary cases, to identify potential mediators of CSC directly regulated by SOX11 in MCL. We observed an enrichment of hematopoietic (HSC) and leukemic stem cells (LSC) gene signatures in SOX11+ compared to SOX11- MCL primary cases. MSI2, an RNA binding protein that maintains self-renewal and prevents differentiation in HSC, emerged as one of the most significant upregulated CSC-related gene in SOX11+ compared to SOX11- MCLs, positively correlating with SOX11 expression in MCL primary cases. Our in vitro experiments showed that SOX11 binds to MSI2 regulatory regions increasing its expression in MCL cells. MSI2 enhancers located in intronic regions were activated in SOX11+ but not in SOX11- MCL cell lines and primary cases. MSI2 upregulation significantly associated with poor overall survival, independently of common risk factors (SOX11 expression, high copy number alterations, 17p/TP53, 11q/ATM and 9p/CDKN2A alterations), in MCL patients. MSI2 knockdown MCL cell lines had a gene expression profile enriched in proapoptotic-related genes; whereas HSC and LSC gene signatures were downregulated compared to its control cells. MSI2 knockdown or MSI2 inhibition with Ro 08-2750 treatment decreased clonogenic growth, tumor survival and chemoresistance in MCL cells. SOX11+/MSI2 high MCL primary leukemic samples showed higher percentage of ALDH+ cells compared to SOX11-/MSI2 low samples, which decreased after Ro 08-2750 treatment. Besides, MSI2 silencing delayed tumor growth in vivo in MCL xenograft mice models. Overall, our results suggest that SOX11+ MCL cases acquire stemness features through the upregulation of MSI2 expression, which promotes chemoresistance, self-renewal and tumor survival. MSI2 represents a novel biomarker for MCL-CSC and therapeutic target for relapsed MCL. Citation Format: Marta Sureda-Gómez, Patricia Balsas, Marta Leonor Rodríguez, Ferran Nadeu, Anna De Bolòs, Álvaro Eguileor, Marta Kulis, Giancarlo Castellano, José Ignacio Martin-Subero, Santiago Demajo, Pedro Jares, Eva Giné, Elias Campo, Virginia Amador. Deciphering the role of MSI2 as a regulator of mantle cell lymphoma stem-like properties [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 777.

The host regulation process has been widely investigated in endophagous parasitoid wasps, which in most cases finely interact with living hosts (i.e. koinobiont parasitoids). In contrast, only very limited information is available for ectophagous parasitoids that permanently paralyze and rapidly suppress their victims (i.e. idiobiont parasitoids). Here we try to fill this research gap by investigating the host regulation by Bracon nigricans, an ectophagous idiobiont wasp species. Parasitism, mainly by venom action, is able to redirect host metabolism in order to enhance its nutritional suitability for the developing parasitoid larvae and to provide the required metabolic support to host tissues. The observed alterations of the host titers of haemolymph proteins, carbohydrates and acylglycerols are associated with a parasitoid-induced mobilization of nutrients stored in the fat body. This tissue undergoes a controlled degradation mediated by a close surface interaction with haemocytes, where a cathepsin L activity is localized, as demonstrated by immunolocalization, biochemical and transcriptional data. B. nigricans parasitism does not markedly influence the survival of haemocytes, even though a persistent suppression of the immune competence is observed in parasitized hosts, which show a reduced capacity to encapsulate and melanize non-self objects. These immune alterations likely allow a more efficient food uptake and use by the ectophagous larvae. The obtained results indicate that the host regulation process in basal lineages of parasitic Hymenoptera is more complex than expected and shares functional similarities with adaptive strategies occurring in derived koinobiont species.

An appraisal of recent data highlighting aspects inspired by the new Geroscience perspective are here discussed. The main findings are summarized as follows: i) liver has to be considered an immunological organ, and new studies suggest a role for the recently described cells named telocytes; ii) the liver-gut axis represents a crucial connection with environment and life style habits and may influence liver diseases onset; iii) the physiological aging of liver shows relatively modest alterations. Nevertheless, several molecular changes appear to be relevant: a) an increase of microRNA-31-5p; -141-3p; -200c-3p expressions after 60 years of age; b) a remodeling of genome-wide DNA methylation profile evident until 60 years of age and then plateauing; c) changes in transcriptome including the metabolic zones of hepatocyte lobules; d) liver undergoes an accelerated aging in presence of chronic inflammation/liver diseases in a sort of continuum, largely as a consequence of unhealthy life styles and exposure to environmental noxious agents. We argue that chronic liver inflammation has all the major characteristics of "inflammaging" and likely sustains the onset and progression of liver diseases. Finally, we propose to use a combination of parameters, mostly obtained by omics such as transcriptomics and epigenomics, to evaluate in deep both the biological age of liver (in comparison with the chronological age) and the effects of donor-recipient age-mismatches in the context of liver transplants.

Background Malnutrition and sarcopenia are common features of frailty. Prevalence of frailty among ST-segment elevation myocardial infarction (STEMI) patients is higher in women than men. Purpose Assess gender-based differences in the impact of nutritional risk index (NRI) and frailty in one-year mortality rate among STEMI patients following primary angioplasty (PA). Methods Cohort of 321 consecutive patients (64 years [54–75]; 22.4% women) admitted to a general ICU after PA for STEMI. NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (actual body weight [kg]/ideal weight [kg]). Vulnerable and moderate to severe NRI patients were those with Clinical Frailty Scale (CFS)≥4 and NRI Results Baseline and mortality variables of 4 groups (NRI-/CFS-; NRI+/CFS-; NRI+/CFS- and NRI+/CFS+) are depicted in the Table. Prevalence of malnutrition, frailty or both were significantly greater in women (34.3%, 10% y 21.4%, respectively) than in men (28.9%, 2.8% y 6.0%, respectively; P Conclusion Among STEMI patients undergoing PA, the prevalence of malnutrition and frailty are significantly higher in women than in men. NRI and frailty had an independent and complementary prognostic impact in women with STEMI. Kaplan-Meier and Cox survival curves Funding Acknowledgement Type of funding source: None

Background The prevalence of undernutrition among hospitalized patients is common and it has been associated to worse clinical outcomes, especially in heart failure and coronary artery disease patients. Female gender has been associated with major adverse events after a ST-segment myocardial infarction (STEMI). Purpose Assess the relationship between gender-based differences in nutritional status and one-year all-cause mortality among hospitalized patients after a primary angioplasty (PA) for STEMI. Methods Cohort of 321 consecutive patients (64.4 years [54.3–75.2]; 22.4% women) admitted to our general ICU after a PA for STEMI between November-2013 and February-2017. NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (actual body weight [kg] / ideal weight [kg]). Patients were dichotomized in no to mild (NRI ≥97.5) and moderate to severe nutritional risk (NRI Results Gender distribution among nutritional risk categories showed a significant degree of association (value 0.251; P=0.017) between female gender and moderate to severe NRI (55.7% women vs. 34.9% men, P=0.002) (Figure 1), independently of frailty (P=0.172). Women had significantly greater one-year mortality rate than men (20.8% vs. 5.2%: OR 4.78, 95% confidence interval [CI], 2.15–10.60, P Conclusion Among STEMI patients undergoing PA, women had a greater nutritional risk than men, regardless of biological frailty, and a greater one-year mortality rate. Undernutrition may be a risk factor implicated in the worse clinical outcome of female gender after STEMI. Figure 1. Gender distribution among NRI categories Funding Acknowledgement Type of funding source: None

Background Undernutrition is a common feature of elderly and hospitalized patients with cardiovascular diseases and is associated with adverse events. Purpose Assess the impact of nutritional risk index (NRI) in one-year mortality in ST-segment elevation myocardial infarction (STEMI) patients following primary angioplasty (PA). Methods Cohort of 319 consecutive patients (64.4 years [54.3–75.2]; 21.9% women) admitted to a general ICU after a PA for STEMI. NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (actual body weight [kg]/ideal weight [kg]). Patients were dichotomized in no to mild (NRI ≥97.5) and moderate to severe (NRI Results Patients with NRI Conclusion Moderate to severe NRI was associated with one-year all-cause mortality in patients undergoing PA for STEMI, regardless of age, female gender, frailty and clinical severity. The prognostic impact of NRI in mortality suggests the need to include its assessment in clinical examination of STEMI patients. Figure 1. Kaplan-Meier and Cox survival curves Funding Acknowledgement Type of funding source: None

There is broad consensus on the health benefits that neonatal screening has provided in Spain, since Professor Mayor Zaragoza began his research project for the early detection of phenylketonuria and other aminoacidopathies in 1968, to date. In these decades there has been a great evolution and development of Neonatal Screening Programs (NSP) in Spain. This paper presents the effect on the development of the NSPs of the decentralization of Public Health responsibilities in the Autonomous Communities, creating differences among them by atomizing the decisions on the expansion of the diseases to be screened. The availability of effective detection and treatment methods was the justification, often unique, for the inclusion of new diseases in an NSP. On rare occasions, neonatal screening was assumed as a public health program that should offer guarantees of effectiveness, from information for informed consent to the correct treatment and follow-up of detected cases. This situation of enormous inequality in access to neonatal screening has changed with the introduction of appropriate legislation to guaranty the correct development of NSP within the National Health System. Forums coordinated by the Ministry of Health with the participation of those responsible for public health from the Autonomous Communities and scientific societies have been fundamental. An example of the convergence of research and science for the benefit of a basic Public Health program.Existe un amplio consenso sobre los beneficios en salud que ha aportado el cribado neonatal en España, desde que el Profesor Mayor Zaragoza iniciara en 1968 su proyecto de investigación para la detección precoz de la fenilcetonuria y otras aminoacidopatías hasta la fecha. En estas décadas se ha producido una gran evolución y desarrollo de los Programas de Cribado Neonatal (PCN) en España. En este trabajo se presenta el efecto de la descentralización de las responsabilidades de Salud Pública en las comunidades autónomas (CCAA) sobre el desarrollo de los PCN, creando diferencias entre ellas al atomizarse las decisiones sobre la ampliación de las enfermedades a cribar. La disponibilidad de métodos de detección y tratamiento eficaces era la justificación, muchas veces exclusiva, para la inclusión de nuevas enfermedades en un PCN. En raras ocasiones se asumía el cribado neonatal como un programa de Salud Pública que debía ofrecer garantías de efectividad, desde la información para el consentimiento informado hasta el correcto tratamiento y seguimiento de los casos detectados. Esta situación de enorme desigualdad en el acceso al cribado neonatal ha cambiado con la introducción de legislación apropiada que garantiza el correcto desarrollo de los PCN dentro del Sistema Nacional de Salud. Los foros coordinados por el Ministerio de Sanidad, con la participación de los responsables de Salud Pública de las CCAA y las sociedades científicas, han sido fundamentales. Un ejemplo de convergencia de la investigación y la ciencia en beneficio de un programa básico de Salud Pública.

Human breast adenocarcinoma cells (MCF7) grow in three-dimensional culture as spheroids that represent the structural complexity of avascular tumors. Therefore, spheroids offer a powerful tool for studying cancer development, aggressiveness, and drug resistance. Notwithstanding the large amount of data regarding the formation of MCF7 spheroids, a detailed description of the morpho-functional changes during their aggregation and maturation is still lacking. In this study, in addition to the already established role of gap junctions, we show evidence of tunneling nanotube (TNT) formation, amyloid fibril production, and opening of large stable cellular bridges, thus reporting the sequential events leading to MCF7 spheroid formation. The variation in cell phenotypes, sustained by dynamic expression of multiple proteins, leads to complex networking among cells similar to the sequence of morphogenetic steps occurring in embryogenesis/organogenesis. On the basis of the observation that early events in spheroid formation are strictly linked to the redox homeostasis, which in turn regulate amyloidogenesis, we show that the administration of N-acetyl-l-cysteine (NAC), a reactive oxygen species (ROS) scavenger that reduces the capability of cells to produce amyloid fibrils, significantly affects their ability to aggregate. Moreover, cells aggregation events, which exploit the intrinsic adhesiveness of amyloid fibrils, significantly decrease following the administration during the early aggregation phase of neutral endopeptidase (NEP), an amyloid degrading enzyme.

Neonatal Screening Programs (PCN) have widely demonstrated their benefits since Dr. Guthrie published his developments on Phenylketonuria (PKU) in 1961. This paper describes how a simple and effective organization, which incorporates all the fundamental actors under the responsibility of the Public Health Directorate (DSP), has managed to ensure that the PCN of the Basque Country meets all the objectives required for a population screening. The acceptance by Basque society of the PCN allowed it to exceed 95% coverage in its second year of operation. Likewise, the limited negative social impact of PCN is evidenced by its low number of false positives and incorrect samples. Excellent response times allow every newborn with a positive result to have an early diagnosis and optimal initiation of treatment. There are two relevant experiences that support the importance of the effective exercise of the responsibility of the DSP. Congenital adrenal hyperplasia (CAH) was incorporated into the PCN in 1991 meeting all technical and clinical criteria. At the request of the experts, the DSP ordered in 1993 to cease this activity showing that it did not provide the expected benefits. The problems of organically integrating the PCN into the healthcare system were also experienced. The need to compete for resources put public health activities, including the PCN, at risk and led to their return to direct dependence on the DSP. The availability of this structure, in addition to facilitating the incorporation of other screenings, allows facing the future challenges.Los Programas de Cribado Neonatal (PCN) han demostrado ampliamente sus beneficios desde que en 1961 el Dr. Guthrie publicó sus trabajos sobre Fenilcetonuria (PKU). En este trabajo se describe cómo una organización sencilla y eficaz, que incorpora a todos los actores fundamentales bajo la responsabilidad de la Dirección de Salud Pública (DSP), ha conseguido que el PCN del País Vasco cumpla con todos los objetivos exigibles a un cribado poblacional. La aceptación por la sociedad vasca del PCN permitió superar el 95% de cobertura en su segundo año de funcionamiento. Asimismo, el limitado impacto social negativo del PCN se evidencia por su reducido número de falsos positivos y de muestras incorrectas. Los excelentes tiempos de respuesta permiten que todo recién nacido con resultado positivo disponga de un diagnóstico temprano y de un inicio óptimo del tratamiento. Hay dos experiencias relevantes que avalan la importancia del ejercicio eficaz de la responsabilidad de la DSP. La hiperplasia adrenal congénita (HAC) se incorporó en 1991 al PCN, cumpliendo con todos los criterios técnicos y clínicos. A petición de los expertos, la DSP ordenó en 1993 cesar esta actividad al evidenciar que no aportaba los beneficios esperados. También se experimentaron los problemas de integrar orgánicamente el PCN en el sistema asistencial. La necesidad de competir por los recursos puso en riesgo las actividades de Salud Pública, incluyendo el PCN, lo que provocó su retorno a la dependencia directa de la DSP. La disponibilidad de esta estructura, además de facilitar la incorporación de otros cribados, permite afrontar los retos del futuro.

The purpose of this study was to analyse whether an extended depth of focus (EDOF) monofocal intraocular lens (IOL) (TECNIS Eyhance™, JohnsonJohnson Surgical Vision, Inc., Santa Ana, CA) provides better intermediate visual acuity (VA) than another monofocal IOL (TECNIS 1-piece™, JohnsonJohnson Surgical Vision, Inc., Santa Ana, CA) from the same platform.Randomised prospective observational study. Patients who required cataract surgery in both eyes were included. Patients in one group were implanted with Tecnis 1-piece IOL and those in the other group with Eyhance EDOF monofocal IOL. One month after surgery in the second eye, we assessed the corrected intermediate VA (66 cm) and obtained defocus curves. We also explored the correlation of: high-order and spherical aberrations with intermediate VA, pupil size with intermediate VA and age with intermediate VA.We analysed 30 patients (60 eyes), 15 patients in the TECNIS 1-piece group and 15 in the Eyhance group. Both groups achieved a far VA of 0.00 logMAR. In contrast, for intermediate vision, VA was better with the Eyhance EDOF monofocal IOLs (0.16 ± 0.12 LogMAR), the difference being statistically significant (p0.001). In addition, binocular intermediate VA was found to be significantly correlated with corneal (6 mm) RMS high-order aberrations (ρ 0.476) and ZThe new EDOF monofocal IOL (Eyhance) offers sufficient depth of focus to provide patients with comfortable vision without impairing far vision.