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1,149 results on '"Efstathiou, Jason A."'

51. Definitions, End Points, and Clinical Trial Designs for Bladder Cancer: Recommendations From the Society for Immunotherapy of Cancer and the International Bladder Cancer Group

Author

Kamat, Ashish M., primary, Apolo, Andrea B., additional, Babjuk, Marek, additional, Bivalacqua, Trinity J., additional, Black, Peter C., additional, Buckley, Roger, additional, Campbell, Matthew T., additional, Compérat, Eva, additional, Efstathiou, Jason A., additional, Grivas, Petros, additional, Gupta, Shilpa, additional, Kurtz, Neil J., additional, Lamm, Donald, additional, Lerner, Seth P., additional, Li, Roger, additional, McConkey, David J., additional, Palou Redorta, Joan, additional, Powles, Thomas, additional, Psutka, Sarah P., additional, Shore, Neal, additional, Steinberg, Gary D., additional, Sylvester, Richard, additional, Witjes, J. Alfred, additional, and Galsky, Matthew D., additional

Published
2023
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53. ATM deficiency confers specific therapeutic vulnerabilities in bladder cancer

Author

Zhou, Yuzhen, primary, Börcsök, Judit, additional, Adib, Elio, additional, Kamran, Sophia C., additional, Neil, Alexander J., additional, Stawiski, Konrad, additional, Freeman, Dory, additional, Stormoen, Dag Rune, additional, Sztupinszki, Zsofia, additional, Samant, Amruta, additional, Nassar, Amin, additional, Bekele, Raie T., additional, Hanlon, Timothy, additional, Valentine, Henkel, additional, Epstein, Ilana, additional, Sharma, Bijaya, additional, Felt, Kristen, additional, Abbosh, Philip, additional, Wu, Chin-Lee, additional, Efstathiou, Jason A., additional, Miyamoto, David T., additional, Anderson, William, additional, Szallasi, Zoltan, additional, and Mouw, Kent W., additional

Published
2023
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54. Genomic Tumor Correlates of Clinical Outcomes Following Organ-Sparing Chemoradiation Therapy for Bladder Cancer

Author

Kamran, Sophia C., primary, Zhou, Yuzhen, additional, Otani, Keisuke, additional, Drumm, Michael, additional, Otani, Yukako, additional, Wu, Shulin, additional, Wu, Chin-Lee, additional, Feldman, Adam S., additional, Wszolek, Matthew, additional, Lee, Richard J., additional, Saylor, Philip J., additional, Lennerz, Jochen, additional, Van Allen, Eliezer, additional, Willers, Henning, additional, Hong, Theodore S., additional, Liu, Yang, additional, Davicioni, Elai, additional, Gibb, Ewan A., additional, Shipley, William U., additional, Mouw, Kent W., additional, Efstathiou, Jason A., additional, and Miyamoto, David T., additional

Published
2023
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55. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines

Author

Alfred Witjes, J., primary, Max Bruins, Harman, additional, Carrión, Albert, additional, Cathomas, Richard, additional, Compérat, Eva, additional, Efstathiou, Jason A., additional, Fietkau, Rainer, additional, Gakis, Georgios, additional, Lorch, Anja, additional, Martini, Alberto, additional, Mertens, Laura S., additional, Meijer, Richard P., additional, Milowsky, Matthew I., additional, Neuzillet, Yann, additional, Panebianco, Valeria, additional, Redlef, John, additional, Rink, Michael, additional, Rouanne, Mathieu, additional, Thalmann, George N., additional, Sæbjørnsen, Sæbjørn, additional, Veskimäe, Erik, additional, and van der Heijden, Antoine G., additional

Published
2023
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61. Long-term results of radiation with or without anti-androgens (AAT) in patients receiving salvage prostate bed radiation therapy (sRT) post prostatectomy.

Author

Lukka, Himu, Pugh, Stephanie L., Shipley, William U., Major, Pierre, Sartor, A. Oliver, Dayes, Ian S., Bahary, Jean-Paul, Efstathiou, Jason A., Pisansky, Thomas Michael, Zeitzer, Kenneth Lee, Lawton, Colleen Anne, Dess, Robert Timothy, Camarata, Andrew S, Balogh, Alexander G., Souhami, Luis, Rosenthal, Seth A., Seiferheld, Wendy, Feng, Felix Y, and Sandler, Howard M.

Published
2024
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63. The Role of Proton Therapy for Prostate Cancer in the Setting of Hip Prosthesis.

Author

Moteabbed, Maryam, Bobić, Mislav, Paganetti, Harald, and Efstathiou, Jason A.

Subjects
HIP surgery, PROSTATE tumors treatment, STATISTICS, RESEARCH, CANCER chemotherapy, RETROSPECTIVE studies, ARTIFICIAL joints, RANDOMIZED controlled trials, PROTON therapy, RESEARCH funding, DESCRIPTIVE statistics, RADIOTHERAPY, DATA analysis, DATA analysis software, RADIATION dosimetry, IMMUNOTHERAPY
Abstract

Simple Summary: As proton therapy evolves and becomes more accessible, it is important to explore its potential value for all patient cases to enable more informed treatment individualization. Currently, external beam radiotherapy for prostate cancer patients with hip prosthesis is limited to photons because traditional proton therapy beams interfere with the implanted hardware. The goal of this study was to investigate the dosimetric feasibility and robustness of novel proton therapy techniques, i.e., proton arc therapy and anterior beam directions for prostate cancer patients with unilateral hip prosthesis. It was demonstrated that proton therapy for prostate cancer in the setting of hip prosthesis is feasible and could potentially reduce the dose to some critical organs and hence reduce toxicities. Purpose: Given that the current standard of proton therapy (PT) for prostate cancer is through bilateral beams, this modality is typically avoided when it comes to treatment of patients with hip prosthesis. The purpose of this study was to evaluate whether novel PT methods, i.e., anterior proton beams and proton arc therapy (PArc), could be feasible options to treat this patient subpopulation. We evaluate PT methods in the context of dosimetry and robustness and compare with standard of practice volumetric modulated arc therapy (VMAT) to explore any potential benefits. Methods: Two PT and one VMAT treatment plans were retrospectively created for 10 patients who participated in a clinical trial with a weekly repeat CT (rCT) imaging component. All plans were robustly optimized and featured: (1) combination anterior oblique and lateral proton beams (AoL), (2) PArc, and (3) VMAT. All patients had hydrogel spacers in place, which enabled safe application of anterior proton beams. The planned dose was 70 Gy (RBE) to the entire prostate gland and 50 Gy (RBE) to the proximal seminal vesicles in 28 fractions. Along with plan dose–volume metrics, robustness to setup and interfractional variations were evaluated using the weekly rCT images. The linear energy transfer (LET)-weighted dose was evaluated for PArc plans to ensure urethra sparing given the typical high-LET region at the end of range. Results: Both PT methods were dosimetrically feasible and provided reduction of some key OAR metrics compared to VMAT except for penile bulb, while providing equally good target coverage. Significant differences in median rectum V35 (22–25%), penile bulb Dmean (5 Gy), rectum V61 (2%), right femoral head Dmean (5 Gy), and bladder V39 (4%) were found between PT and VMAT. All plans were equally robust to variations. LET-weighted dose in urethra was equivalent to the physical dose for PArc plans and hence no added urethral toxicity was expected. Conclusions: PT for treatment of prostate cancer patients with hip prosthesis is feasible and equivalent or potentially superior to VMAT in quality in some cases. The choice of radiotherapy regimen can be personalized based on patient characteristics to achieve the best treatment outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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76. Impact of an Expanded Definition of Family History on Outcomes of Active Surveillance for Prostate Cancer

Author

Schneider, Adam C., primary, Chandrasekar, Thenappan, additional, Bowler, Nicholas, additional, Fogg, Ryan, additional, Leong, Joon Yau, additional, Gusev, Andrew, additional, Rodgers, Linda H., additional, McCormick, Shelley R., additional, Dahl, Douglas M., additional, Efstathiou, Jason A., additional, Blute, Michael L., additional, Zietman, Anthony L., additional, Wu, Chin-Lee, additional, Smith, Matthew R., additional, Van Allen, Eliezer M., additional, Feldman, Adam S., additional, and Salari, Keyan, additional

Published
2023
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77. Dose-Escalated Radiotherapy Alone or in Combination With Short-Term Androgen Deprivation for Intermediate-Risk Prostate Cancer: Results of a Phase III Multi-Institutional Trial

Author

Krauss, Daniel J., primary, Karrison, Theodore, additional, Martinez, Alvaro A., additional, Morton, Gerard, additional, Yan, Di, additional, Bruner, Deborah Watkins, additional, Movsas, Benjamin, additional, Elshaikh, Mohamed, additional, Citrin, Deborah, additional, Hershatter, Bruce, additional, Michalski, Jeff M., additional, Efstathiou, Jason Alexander, additional, Currey, Adam, additional, Kavadi, Vivek S., additional, Cury, Fabio L., additional, Lock, Michael, additional, Raben, Adam, additional, Seaward, Samantha Andrews, additional, El-Gayed, Ali, additional, Rodgers, Joseph P., additional, and Sandler, Howard M., additional

Published
2023
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78. Data from An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer

Author

Miyamoto, David T., primary, Lee, Richard J., primary, Kalinich, Mark, primary, LiCausi, Joseph A., primary, Zheng, Yu, primary, Chen, Tianqi, primary, Milner, John D., primary, Emmons, Erin, primary, Ho, Uyen, primary, Broderick, Katherine, primary, Silva, Erin, primary, Javaid, Sarah, primary, Kwan, Tanya Todorova, primary, Hong, Xin, primary, Dahl, Douglas M., primary, McGovern, Francis J., primary, Efstathiou, Jason A., primary, Smith, Matthew R., primary, Sequist, Lecia V., primary, Kapur, Ravi, primary, Wu, Chin-Lee, primary, Stott, Shannon L., primary, Ting, David T., primary, Giobbie-Hurder, Anita, primary, Toner, Mehmet, primary, Maheswaran, Shyamala, primary, and Haber, Daniel A., primary

Published
2023
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80. Tables S1, S2, S3, S4, S5 from An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer

Author

Miyamoto, David T., primary, Lee, Richard J., primary, Kalinich, Mark, primary, LiCausi, Joseph A., primary, Zheng, Yu, primary, Chen, Tianqi, primary, Milner, John D., primary, Emmons, Erin, primary, Ho, Uyen, primary, Broderick, Katherine, primary, Silva, Erin, primary, Javaid, Sarah, primary, Kwan, Tanya Todorova, primary, Hong, Xin, primary, Dahl, Douglas M., primary, McGovern, Francis J., primary, Efstathiou, Jason A., primary, Smith, Matthew R., primary, Sequist, Lecia V., primary, Kapur, Ravi, primary, Wu, Chin-Lee, primary, Stott, Shannon L., primary, Ting, David T., primary, Giobbie-Hurder, Anita, primary, Toner, Mehmet, primary, Maheswaran, Shyamala, primary, and Haber, Daniel A., primary

Published
2023
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81. Figures S1, S2, S3, S4, S5, S6 from An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer

Author

Miyamoto, David T., primary, Lee, Richard J., primary, Kalinich, Mark, primary, LiCausi, Joseph A., primary, Zheng, Yu, primary, Chen, Tianqi, primary, Milner, John D., primary, Emmons, Erin, primary, Ho, Uyen, primary, Broderick, Katherine, primary, Silva, Erin, primary, Javaid, Sarah, primary, Kwan, Tanya Todorova, primary, Hong, Xin, primary, Dahl, Douglas M., primary, McGovern, Francis J., primary, Efstathiou, Jason A., primary, Smith, Matthew R., primary, Sequist, Lecia V., primary, Kapur, Ravi, primary, Wu, Chin-Lee, primary, Stott, Shannon L., primary, Ting, David T., primary, Giobbie-Hurder, Anita, primary, Toner, Mehmet, primary, Maheswaran, Shyamala, primary, and Haber, Daniel A., primary

Published
2023
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82. Supplementary Figure Legends from Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers

Author

Liu, Qi, primary, Wang, Meng, primary, Kern, Ashley M., primary, Khaled, Saman, primary, Han, Jing, primary, Yeap, Beow Y., primary, Hong, Theodore S., primary, Settleman, Jeff, primary, Benes, Cyril H., primary, Held, Kathryn D., primary, Efstathiou, Jason A., primary, and Willers, Henning, primary

Published
2023
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85. PD09-03 INVERSE PROBABILITY TREATMENT WEIGHTING COMPARISON OF RADICAL CYSTECTOMY TO TRIMODALITY THERAPY FOR CT2-CT4 MUSCLE INVASIVE BLADDER CANCER

Author

Zlotta, Alexandre, primary, Ballas, Leslie, additional, Niemierko, Andrzej, additional, Lajkosz, Katherine, additional, Kuk, Cynthia, additional, Miranda, Gus, additional, Drumm, Michael, additional, Mari, Andrea, additional, Thio, Ethan, additional, Fleshner, Neil, additional, Kulkarni, Girish, additional, Jewett, Michael, additional, Bristow, Rob, additional, Catton, Charles, additional, Warde, Padraig, additional, Berlin, Alejandro, additional, Sridhar, Srikala, additional, Schuckman, Anne, additional, Djaladat, Hooman, additional, Feldman, Adam, additional, Wszolek, Matthew, additional, Dahl, Douglas, additional, Lee, Richard, additional, Saylor, Philip, additional, Michaelson, Marc, additional, Miyamoto, David, additional, Zietman, Anthony, additional, Shipley, William, additional, Chung, Peter, additional, Daneshmand, Sia, additional, and Efstathiou, Jason, additional

Published
2023
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88. Ensuring Successful Biomarker Studies in Bladder Preservation Clinical Trials for Non-muscle Invasive Bladder Cancer

Author

McConkey, David J., Baumann, Brian C., Cooper Greenberg, Stephanie, DeGraff, David J., Delacroix, Scott E., Efstathiou, Jason A., Foster, Jared, Groshen, Susan, Kadel, Edward E., Khani, Francesca, Kim, William Y., Lerner, Seth P., Levin, Trevor, Liao, Joseph C., Milowsky, Matthew I., Meeks, Joshua J., Miyamoto, David T., Mouw, Kent W., Pietzak, Eugene J., Solit, David B., Sundi, Debasish, Tawab-Amiri, Abdul, West, Pamela J., Wobker, Sara E., Wyatt, Alexander W., Apolo, Andrea B., and Black, Peter C.

Published
2024
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91. Bladder cancer

Author

Kamat, Ashish M, Hahn, Noah M, Efstathiou, Jason A, Lerner, Seth P, Malmström, Per-Uno, Choi, Woonyoung, Guo, Charles C, Lotan, Yair, and Kassouf, Wassim

Published
2016
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93. Salvage Radiation Therapy Dose Response for Biochemical Failure of Prostate Cancer After Prostatectomy—A Multi-Institutional Observational Study

Author

Pisansky, Thomas M., Agrawal, Shree, Hamstra, Daniel A., Koontz, Bridget F., Liauw, Stanley L., Efstathiou, Jason A., Michalski, Jeff M., Feng, Felix Y., Abramowitz, Matthew C., Pollack, Alan, Anscher, Mitchell S., Moghanaki, Drew, Den, Robert B., Stephans, Kevin L., Zietman, Anthony L., Lee, W. Robert, Kattan, Michael W., Stephenson, Andrew J., and Tendulkar, Rahul D.

Published
2016
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99. Supplementary Data from Molecular Characterization of Neuroendocrine-like Bladder Cancer

Author

Batista da Costa, José, primary, Gibb, Ewan A., primary, Bivalacqua, Trinity J., primary, Liu, Yang, primary, Oo, Htoo Zarni, primary, Miyamoto, David T., primary, Alshalalfa, Mohammed, primary, Davicioni, Elai, primary, Wright, Jonathan, primary, Dall’Era, Marc A., primary, Douglas, James, primary, Boormans, Joost L., primary, Van der Heijden, Michiel S., primary, Wu, Chin-Lee, primary, van Rhijn, Bas W.G., primary, Gupta, Shilpa, primary, Grivas, Petros, primary, Mouw, Kent W., primary, Murugan, Paari, primary, Fazli, Ladan, primary, Ra, Seong, primary, Konety, Badrinath R., primary, Seiler, Roland, primary, Daneshmand, Siamak, primary, Mian, Omar Y., primary, Efstathiou, Jason A., primary, Lotan, Yair, primary, and Black, Peter C., primary

Published
2023
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100. Supplementary Figures from Molecular Characterization of Neuroendocrine-like Bladder Cancer

Author

Batista da Costa, José, primary, Gibb, Ewan A., primary, Bivalacqua, Trinity J., primary, Liu, Yang, primary, Oo, Htoo Zarni, primary, Miyamoto, David T., primary, Alshalalfa, Mohammed, primary, Davicioni, Elai, primary, Wright, Jonathan, primary, Dall’Era, Marc A., primary, Douglas, James, primary, Boormans, Joost L., primary, Van der Heijden, Michiel S., primary, Wu, Chin-Lee, primary, van Rhijn, Bas W.G., primary, Gupta, Shilpa, primary, Grivas, Petros, primary, Mouw, Kent W., primary, Murugan, Paari, primary, Fazli, Ladan, primary, Ra, Seong, primary, Konety, Badrinath R., primary, Seiler, Roland, primary, Daneshmand, Siamak, primary, Mian, Omar Y., primary, Efstathiou, Jason A., primary, Lotan, Yair, primary, and Black, Peter C., primary

Published
2023
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