77 results on '"Eckhoff, J."'
Search Results
52. Seed Spacing for Nonthinned Sugarbeet Production
- Author
-
Eckhoff, J. L. A., primary, Halvorson, A. D., additional, Weiss, M. J., additional, and Bergman, J .W., additional
- Published
- 1991
- Full Text
- View/download PDF
53. Watershed Nitrogen and Mercury Geochemical Fluxes Integrate Landscape Factors in Long-term Research Watersheds at Acadia National Park, Maine, USA.
- Author
-
Kahl, J., Nelson, S., Fernandez, I., Haines, T., Norton, S., Wiersma, G., Jacobson, G., Amirbahman, A., Johnson, K., Schauffler, M., Rustad, L., Tonnessen, K., Lent, R., Bank, M., Elvir, J., Eckhoff, J., Caron, H., Ruck, P., Parker, J., and Campbell, J.
- Subjects
WATERSHEDS ,LANDSCAPES ,NITROGEN ,MERCURY ,GEOCHEMISTRY ,ACADIA National Park (Me.) - Abstract
This paper is an overview of this special issue devoted to watershed research in Acadia National Park (Acadia NP). The papers address components of an integrated research program on two upland watersheds at Acadia NP, USA (44° 20′ N latitude; 68° 15′ E longitude). These watersheds were instrumented in 1998 to provide a long-term foundation for regional ecological and watershed research. The research was initiated as part of EPA/NPS PRIMENet (Park Research and Intensive Monitoring of Ecosystems Network), a system of UV-monitoring stations and long-term watershed research sites located in US national parks. The initial goals at Acadia NP were to address research questions about mercury, acid rain, and nitrogen saturation developed from prior research. The project design was based on natural differences in forests and soils induced by an intense wildfire in one watershed in 1947. There is no evidence of fire in the reference watershed for several hundred years. We are testing hypotheses about controls on surface water chemistry, and bioavailability of contaminants in the contrasting watersheds. The unburned 47-ha Hadlock Brook watershed is 70% spruce-fir mature conifer forest. In contrast, burned 32-ha Cadillac Brook watershed, 4 km northeast of the Hadlock watershed, is 20% regenerating mixed northern hardwoods and 60% shrub/rocky balds. Differences in atmospheric deposition are controlled primarily by forest stand composition and age. The watersheds are gauged and have water chemistry stations at 122 m (Cadillac) and 137 m (Hadlock); watershed maximum elevations are 468 and 380 m, respectively. The stream water chemistry patterns reflect, in part, the legacy of the intense fire, which, in turn, controls differences in forest vegetation and soil characteristics. These factors result in higher nitrogen and mercury flux from the unburned watershed, reflecting differences in atmospheric deposition, contrasting ecosystem pools of nitrogen and mercury, and inferred differences in internal cycling and bioavailabilty. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
54. Registration of Wanubet, a Hulless, Waxy Barley Germplasm
- Author
-
Eslick, R. F., primary, Blake, T., additional, Stallknecht, G., additional, Jackson, G., additional, Eckhoff, J., additional, Carlson, G., additional, Kushnak, G., additional, and Stewart, V., additional
- Published
- 1990
- Full Text
- View/download PDF
55. Registration of ‘Shonkin’ Barley
- Author
-
Blake, T., primary, Hensleigh, P., additional, Eslick, R. F., additional, Stallknecht, G., additional, Jackson, G., additional, Eckhoff, J., additional, Carlson, G., additional, Kushnak, G., additional, and Stewart, V., additional
- Published
- 1990
- Full Text
- View/download PDF
56. Registration of ‘Bearpaw’ Barley
- Author
-
Hockett, E. A., primary, Blake, T. K., additional, Carlson, G. R., additional, Cook, A. F., additional, Kushnak, G. D., additional, Jackson, G. D., additional, Eckhoff, J. L., additional, Stewart, V. R., additional, Stallknecht, G. F., additional, and Davis, M. P., additional
- Published
- 1990
- Full Text
- View/download PDF
57. Primitive Radon partitions.
- Author
-
Eckhoff, J.
- Abstract
Radon's theorem [8] asserts that, if X is a finite set of s points in Rd and s ≥ d + 2, then X admits a. Radon partition, that is, a partition {X1; X2} of X into disjoint subsets X1 and X2, such that [ABSTRACT FROM PUBLISHER]
- Published
- 1974
- Full Text
- View/download PDF
58. The Upper-Bound Theorem for Families of Boxes in d
- Author
-
Eckhoff, J?rgen
- Abstract
AbstractLet be a family of axis-aligned parallelotopes, or boxes, in d. Denote by fk() the number of subfamilies of of size k+ 1 with non-empty intersection. In an earlier paper, the author proved that, if f0() = nand fr() = 0, then fk() ? fk(n, d, r) for k= 1,?,r? 1, where fk(n, d, r) is some explicitly given number. The result is best possible for all k. Here it is shown that, if equality is attained for somesuch k, then equality is attained for eachsuch k.
- Published
- 2007
- Full Text
- View/download PDF
59. The partition conjecture
- Author
-
Eckhoff, J.
- Published
- 2000
- Full Text
- View/download PDF
60. The maximum number of triangles in a K~4-free graph
- Author
-
Eckhoff, J.
- Published
- 1999
- Full Text
- View/download PDF
61. A Gallai-Type Transversal Problem in the Plane.
- Author
-
Eckhoff, J. and Eckhoff, J.
62. An Upper-Bound theorem for families of convex sets
- Author
-
Eckhoff, J�rgen, primary
- Published
- 1985
- Full Text
- View/download PDF
63. Families of convex sets having convex union
- Author
-
Eckhoff, J�rgen, primary
- Published
- 1987
- Full Text
- View/download PDF
64. Transversalenprobleme in der Ebene
- Author
-
Eckhoff, J�rgen, primary
- Published
- 1973
- Full Text
- View/download PDF
65. Der Satz von Radon in konvexen Produktstrukturen II
- Author
-
Eckhoff, J�rgen, primary
- Published
- 1969
- Full Text
- View/download PDF
66. Der Satz von Radon in konvexen Produktstrukturen I
- Author
-
Eckhoff, J�rgen, primary
- Published
- 1968
- Full Text
- View/download PDF
67. Registration of ‘Vida’ Wheat.
- Author
-
Lanning, S. P., Carlson, G. R., Nash, D., Wichman, D. M., Kephart, K. D., Stougaard, R. N., Kushnak, G. D., Eckhoff, J. L., Grey, W. E., Dyer, A., and Talbert, L. E.
- Subjects
WHEAT ,CULTIVARS ,PLANT breeding ,PLANT biotechnology ,SELECTION (Plant breeding) ,POLLEN management ,SPECIES hybridization ,CROP science ,AGRICULTURE - Abstract
The article provides information on the breed-enhanced plant variety Vida wheat. Released in 2006, the plant variety is a hard red spring wheat developed by the Montana Agricultural Experiment Station. It was derived from an F
4 plant selection from the cross Scholar and Reeder wheat variety. In addition, Vida has mid-dense and tapering heads with white awns and glumes. It has a semisolid stems due to the presence of a gene for stem solidness. Furthermore, Vida has shown high yield potential.- Published
- 2006
- Full Text
- View/download PDF
68. Registration of 'Paul' Wheat.
- Author
-
Bruckner, P. L., Berg, J. E., Carlson, G. R., Riveland, N., Wichman, D. M., Kephart, K .D., Kushnak, G. D., Stougaard, R. N., Eckhoff, J. L., Hockett, E .A., and Nash, D. L.
- Subjects
CULTIVARS ,WINTER wheat ,WHEAT ,WINTER grain ,CROPS ,CROP science ,AGRICULTURE - Abstract
The article describes Paul hard red winter wheat cultivar, which was developed by the Montana and North Dakota Agricultural Experiment Stations. Paul's release in August 2003 was based on its high yield potential and superior winter survival in rain-fed environments of Montana. Paul was selected from the cross MT8030/Neeley made in 1985. Neeley was the leading winter wheat cultivar in Montana for 15 consecutive years. And on the basis of field observations and cooperative evaluations through the U.S. Department of Agriculture's Regional Testing Program, Paul was found to be moderately susceptible to stem rust, leaf rust and stripe rust.
- Published
- 2006
- Full Text
- View/download PDF
69. Registration of 'Genou' Wheat.
- Author
-
Bruckner, P. L., Berg, J. E., Kushnak, G. D., Stougaard, R. N., Eckhoff, J. L., Carlson, G. R., Wichman, D. M., Kephart, K. D., Riveland, N., and Nash, D. L.
- Subjects
CULTIVARS ,WINTER wheat ,WHEAT ,WINTER grain ,CROPS ,CULTIVATED plants ,CROP science ,AGRICULTURE - Abstract
The article describes Genou hard red winter wheat cultivar, which was developed by the Montana Agricultural Experiment Station. Genou was released in August 2004 for its host plant resistance to the wheat stem sawfly. It also had improved yield potential and cold tolerance relative to other solid-stem winter wheat cultivars adapted to Montana. Stem solidness of Genou was evaluated on the scale of five, which is hollow, to 25, which is solid. On the basis of limited field observations, Genou was moderately susceptible to stem rust, leaf rust and stripe rust.
- Published
- 2006
- Full Text
- View/download PDF
70. Feasibility and Potential of Transcriptomic Analysis Using the NanoString nCounter Technology to Aid the Classification of Rejection in Kidney Transplant Biopsies.
- Author
-
Varol H, Ernst A, Cristoferi I, Arns W, Baan CC, van Baardwijk M, van den Bosch T, Eckhoff J, Harth A, Hesselink DA, van Kemenade FJ, de Koning W, Kurschat C, Minnee RC, Mustafa DA, Reinders MEJ, Shahzad-Arshad SP, Snijders MLH, Stippel D, Stubbs AP, von der Thüsen J, Wirths K, Becker JU, and Clahsen-van Groningen MC
- Subjects
- Humans, Graft Rejection diagnosis, Graft Rejection genetics, Graft Rejection pathology, Feasibility Studies, Transcriptome, Retrospective Studies, Antibodies, Gene Expression Profiling, Biopsy, Kidney Transplantation adverse effects
- Abstract
Background: Transcriptome analysis could be an additional diagnostic parameter in diagnosing kidney transplant (KTx) rejection. Here, we assessed feasibility and potential of NanoString nCounter analysis of KTx biopsies to aid the classification of rejection in clinical practice using both the Banff-Human Organ Transplant (B-HOT) panel and a customized antibody-mediated rejection (AMR)-specific NanoString nCounter Elements (Elements) panel. Additionally, we explored the potential for the classification of KTx rejection building and testing a classifier within our dataset., Methods: Ninety-six formalin-fixed paraffin-embedded KTx biopsies were retrieved from the archives of the ErasmusMC Rotterdam and the University Hospital Cologne. Biopsies with AMR, borderline or T cell-mediated rejections (BLorTCMR), and no rejection were compared using the B-HOT and Elements panels., Results: High correlation between gene expression levels was found when comparing the 2 chemistries pairwise (r = 0.76-0.88). Differential gene expression (false discovery rate; P < 0.05) was identified in biopsies diagnosed with AMR (B-HOT: 294; Elements: 76) and BLorTCMR (B-HOT: 353; Elements: 57) compared with no rejection. Using the most predictive genes from the B-HOT analysis and the Element analysis, 2 least absolute shrinkage and selection operators-based regression models to classify biopsies as AMR versus no AMR (BLorTCMR or no rejection) were developed achieving an receiver-operating-characteristic curve of 0.994 and 0.894, sensitivity of 0.821 and 0.480, and specificity of 1.00 and 0.979, respectively, during cross-validation., Conclusions: Transcriptomic analysis is feasible on KTx biopsies previously used for diagnostic purposes. The B-HOT panel has the potential to differentiate AMR from BLorTCMR or no rejection and could prove valuable in aiding kidney transplant rejection classification., Competing Interests: M.C.C.v.G. has Astellas project funding paid to the Erasmus MC. J.U.B. is advisor for Sanofi. The other authors declare no conflicts of interest., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2023
- Full Text
- View/download PDF
71. Time to endoscopic vacuum therapy-lessons learned after > 150 robotic-assisted minimally invasive esophagectomies (RAMIE) at a German high-volume center.
- Author
-
Chon SH, Brunner S, Müller DT, Lorenz F, Stier R, Streller L, Eckhoff J, Straatman J, Babic B, Schiffmann LM, Schröder W, Schmidt T, Bruns CJ, and Fuchs HF
- Subjects
- Humans, Esophagectomy adverse effects, Anastomotic Leak etiology, Anastomotic Leak surgery, Treatment Outcome, Retrospective Studies, Boehmeria, Robotic Surgical Procedures adverse effects, Negative-Pressure Wound Therapy methods, COVID-19
- Abstract
Objective of the Study: In esophageal surgery, anastomotic leak (AL) remains one of the most severe and critical adverse events after oncological esophagectomy. Endoscopic vacuum therapy (EVT) can be used to treat AL; however, in the current literature, treatment outcomes and reports on how to use this novel technique are scarce. The aim of this study was to evaluate the outcomes of patients with an AL after IL RAMIE and to determine whether using EVT as an treatment option is safe and feasible., Material and Methods: This study includes all patients who developed an Esophagectomy Complications Consensus Group (ECCG) type II AL after IL RAMIE at our center between April 2017 and December 2021. The analysis focuses on time to EVT, duration of EVT, and follow up treatments for these patients., Results: A total of 157 patients underwent an IL RAMIE at our hospital. 21 patients of these (13.4%) developed an ECCG type II AL. One patient died of unrelated Covid-19 pneumonia and was excluded from the study cohort. The mean duration of EVT was 12 days (range 4-28 days), with a mean of two sponge changes (range 0-5 changes). AL was diagnosed at a mean of 8 days post-surgery (range 2-16 days). Closure of the AL with EVT was successful in 15 out of 20 patients (75%). Placement of a SEMS (Self-expandlable metallic stent) after EVT was performed in four patients due to persisting AL. Overall success rate of anastomotic sealing independently of the treatment modality was achieved in 19 out of 20 Patients (95%). No severe EVT-related adverse events occurred., Conclusion: This study shows that EVT can be a safe and effective endoscopic treatment option for ECCG type II AL., (© 2022. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
72. [ICG lymph node mapping in cancer surgery of the upper gastrointestinal tract].
- Author
-
Müller D, Stier R, Straatman J, Babic B, Schiffmann L, Eckhoff J, Schmidt T, Bruns C, and Fuchs HF
- Subjects
- Artificial Intelligence, Fluorescent Dyes, Humans, Indocyanine Green, Lymph Nodes diagnostic imaging, Lymphatic Metastasis diagnostic imaging, Optical Imaging methods, Prospective Studies, Sentinel Lymph Node Biopsy methods, Esophageal Neoplasms diagnostic imaging, Stomach Neoplasms diagnostic imaging, Upper Gastrointestinal Tract pathology
- Abstract
The importance of the assessment of the N‑status in gastric carcinoma, tumors of the gastroesophageal junction and esophageal cancer is undisputed; however, there is currently no internationally validated method for lymph node mapping in esophageal and gastric cancer. Near-infrared fluorescence imaging (NIR) is an innovative technique from the field of vibrational spectroscopy, which in combination with the fluorescent dye indocyanine green (ICG) enables intraoperative real-time visualization of anatomical structures. The ICG currently has four fields of application in oncological surgery: intraoperative real-time angiography for visualization of perfusion, lymphography for visualization of lymphatic vessels, visualization of solid tumors, and (sentinel) lymph node mapping. For imaging of the lymph drainage area and therefore the consecutive lymph nodes, peritumoral injection of ICG must be performed. Several studies have demonstrated the feasibility of peritumoral injection of ICG administered 15 min to 3 days preoperatively with subsequent intraoperative visualization of the lymph nodes. So far prospective randomized studies on the validation of the method are still lacking. In contrast, the use of ICG for lymph node mapping and visualization of sentinel lymph nodes in gastric cancer has been performed in large cohorts as well as in prospective randomized settings. Up to now, multicenter studies for ICG-guided lymph node mapping during oncological surgery of the upper gastrointestinal tract are lacking. Artificial intelligence methods can help to evaluate these techniques in an automated manner in the future as well as to support intraoperative decision making and therefore to improve the quality of oncological surgery., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2022
- Full Text
- View/download PDF
73. Effect of Pulmonary Rehabilitation on Inspiratory Capacity During 6-min Walk Test in Patients With COPD: A PROSPECTIVE CONTROLLED STUDY.
- Author
-
Spielmanns M, Boeselt T, Nell C, Eckhoff J, Koczulla RA, Magnet FS, Storre JH, Windisch W, and Baum K
- Subjects
- Aged, Female, Humans, Inspiratory Capacity, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Walk Test, Exercise Therapy methods, Pulmonary Disease, Chronic Obstructive physiopathology, Pulmonary Disease, Chronic Obstructive rehabilitation, Walking physiology
- Abstract
Purpose: Purpose of this study was to analyze the impact of a pulmonary rehabilitation (PR) program on the measured inspiratory capacity (IC) in patients with chronic obstructive pulmonary disease (COPD) while performing a 6-min walk test (6MWT)., Methods: Before and after PR, IC was measured by spirometry both at the beginning and at the end of the 6MWT for 15 patients with COPD in the PR group (PRG) and compared with a similar calisthenics training group (CTG; n = 15). In addition, the COPD Assessment Test (CAT), St George's Respiratory Questionnaire (SGRQ), and other lung function tests were recorded and compared., Results: Both groups were not significantly different at baseline. Compared with the CTG, the PRG achieved a significant increase in the delta of IC measured during the 6MWT (0.5 ± 0.2 L [PRG] vs -0.2 + 0.2 L [CTG], P = .001). Significant differences were found for the 6MWT walking distance (PRG: 99 ± 36 m vs CTG: 5 ± 25 m, P = .001). No significant increase in dyspnea while performing the 6MWT was found in either group. The differences in the CAT score and the SGRQ Global score were significant only for the PRG in intragroup comparisons, whereas the intergroup comparison showed no significant differences. Except for residual volume, no significant changes in all parameters of the static lung function tests were observed in either group., Conclusion: Participation in a PR may lead to a significant and clinically relevant increase in IC and the walking distance. Additional research is necessary to define the effects of this increase in IC on exercise capacity.
- Published
- 2018
- Full Text
- View/download PDF
74. In Vitro Characterization of Chain Depolymerization Activities of SUMO-Specific Proteases.
- Author
-
Eckhoff J and Dohmen RJ
- Subjects
- Cloning, Molecular, Endopeptidases genetics, Enzyme Assays, Escherichia coli genetics, Escherichia coli metabolism, Gene Expression, Genetic Vectors chemistry, Genetic Vectors metabolism, Histidine genetics, Histidine metabolism, Hydrolysis, Maltose-Binding Proteins genetics, Maltose-Binding Proteins metabolism, Oligopeptides genetics, Oligopeptides metabolism, Recombinant Fusion Proteins genetics, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae Proteins genetics, Small Ubiquitin-Related Modifier Proteins genetics, Substrate Specificity, Sumoylation, Endopeptidases metabolism, Protein Processing, Post-Translational, Recombinant Fusion Proteins metabolism, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins metabolism, Small Ubiquitin-Related Modifier Proteins metabolism
- Abstract
SUMO-specific proteases, known as Ulps in baker's yeast and SENPs in humans, have important roles in controlling the dynamics of SUMO-modified proteins. They display distinct modes of action and specificity, in that they may act on the SUMO precursor, mono-sumoylated, and/or polysumoylated proteins, and they might be specific for substrates with certain SUMO paralogs. SUMO chains may be dismantled either by endo or exo mechanisms. Biochemical characterization of a protease usually requires purification of the protein of interest. Developing a purification protocol, however, can be very difficult, and in some cases, isolation of a protease in its pure form may go along with a substantial loss of activity. To characterize the reaction mechanism of Ulps, we have developed an in vitro assay, which makes use of substrates endowed with artificial poly-SUMO chains of defined lengths, and S. cerevisiae Ulp enzymes in crude extract from E. coli. This fast and economic approach should be applicable to SUMO-specific proteases from other species as well.
- Published
- 2016
- Full Text
- View/download PDF
75. Impact of the D genome and quantitative trait loci on quantitative traits in a spring durum by spring bread wheat cross.
- Author
-
Kalous JR, Martin JM, Sherman JD, Heo HY, Blake NK, Lanning SP, Eckhoff JL, Chao S, Akhunov E, and Talbert LE
- Subjects
- Alleles, Chromosome Mapping, DNA, Plant genetics, Genetic Linkage, Inbreeding, Microsatellite Repeats, Phenotype, Plant Breeding, Ploidies, Polymorphism, Single Nucleotide, Crosses, Genetic, Genome, Plant, Quantitative Trait Loci, Quantitative Trait, Heritable, Triticum genetics
- Abstract
The impact of the D genome and QTL in the A and B genomes on agronomic performance of hexaploid wheat and tetraploid durum was determined using novel recombinant inbred line populations derived from interploid crosses. Genetic differences between common hexaploid (6X) bread wheat (Triticum aestivum, 2n = 6x = 42, genome, AABBDD) and tetraploid (4X) durum wheat (T. turgidum subsp. durum, 2n = 4x = 28, genome, AABB) may exist due to effects of the D genome and allelic differences at loci in the A and B genomes. Previous work allowed identification of a 6X by 4X cross combination that resulted in a large number of fertile recombinant progeny at both ploidy levels. In this study, interspecific recombinant inbred line populations at both 4X and 6X ploidy with 88 and 117 individuals, respectively, were developed from a cross between Choteau spring wheat (6X) and Mountrail durum wheat (4X). The presence of the D genome in the 6X population resulted in increased yield, tiller number, kernel weight, and kernel size, as well as a decrease in stem solidness, test weight and seed per spike. Similar results were found with a second RIL population containing 152 lines from 18 additional 6X by 4X crosses. Several QTL for agronomic and quality traits were identified in both the 4X and 6X populations. Although negatively impacted by the lack of the D genome, kernel weight in Mountrail (4X) was higher than Choteau (6X) due to positive alleles from Mountrail on chromosomes 3B and 7A. These and other favorable alleles may be useful for introgression between ploidy levels.
- Published
- 2015
- Full Text
- View/download PDF
76. In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.
- Author
-
Eckhoff J and Dohmen RJ
- Subjects
- Cloning, Molecular, Escherichia coli metabolism, Green Fluorescent Proteins metabolism, Open Reading Frames, Plasmids metabolism, Protein Binding, Protein Folding, Protein Processing, Post-Translational, Protein Structure, Tertiary, Saccharomyces cerevisiae metabolism, Endopeptidases metabolism, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae Proteins metabolism, Small Ubiquitin-Related Modifier Proteins metabolism
- Abstract
Sumoylation is a post-translational modification essential in most eukaryotes that regulates stability, localization, activity, or interaction of a multitude of proteins. It is a reversible process wherein counteracting ligases and proteases, respectively, mediate the conjugation and deconjugation of SUMO molecules to/from target proteins. Apart from attachment of single SUMO moieties to targets, formation of poly-SUMO chains occurs by the attachment of additional SUMO molecules to lysine residues in the N-terminal extensions of SUMO. In Saccharomyces cerevisiae there are apparently only two SUMO(Smt3)-specific proteases: Ulp1 and Ulp2. Ulp2 has been shown to be important for the control of poly-SUMO conjugates in cells and to dismantle SUMO chains in vitro, but the mechanism by which it acts remains to be elucidated. Applying an in vitro approach, we found that Ulp2 acts sequentially rather than stochastically, processing substrate-linked poly-SUMO chains from their distal ends down to two linked SUMO moieties. Furthermore, three linked SUMO units turned out to be the minimum length of a substrate-linked chain required for efficient binding to and processing by Ulp2. Our data suggest that Ulp2 disassembles SUMO chains by removing one SUMO moiety at a time from their ends (exo mechanism). Apparently, Ulp2 recognizes surfaces at or near the N terminus of the distal SUMO moiety, as attachments to this end significantly reduce cleavage efficiency. Our studies suggest that Ulp2 controls the dynamic range of SUMO chain lengths by trimming them from the distal ends., (© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.)
- Published
- 2015
- Full Text
- View/download PDF
77. Short-term effects of inhalative tiotropium/formoterol/budenoside versus tiotropium/formoterol in patients with newly diagnosed chronic obstructive pulmonary disease requiring surgery for lung cancer: a prospective randomized trial.
- Author
-
Bölükbas S, Eberlein M, Eckhoff J, and Schirren J
- Subjects
- Administration, Inhalation, Adrenal Cortex Hormones administration & dosage, Aged, Airway Resistance drug effects, Bronchodilator Agents administration & dosage, Budesonide administration & dosage, Budesonide, Formoterol Fumarate Drug Combination, Carcinoma, Non-Small-Cell Lung complications, Drug Combinations, Drug Therapy, Combination, Epidemiologic Methods, Ethanolamines administration & dosage, Forced Expiratory Volume drug effects, Humans, Lung Neoplasms complications, Middle Aged, Plethysmography, Whole Body methods, Pneumonectomy adverse effects, Preoperative Care methods, Pulmonary Disease, Chronic Obstructive complications, Pulmonary Disease, Chronic Obstructive physiopathology, Scopolamine Derivatives administration & dosage, Smoking Cessation, Tiotropium Bromide, Treatment Outcome, Vital Capacity drug effects, Adrenal Cortex Hormones therapeutic use, Bronchodilator Agents therapeutic use, Budesonide therapeutic use, Carcinoma, Non-Small-Cell Lung surgery, Ethanolamines therapeutic use, Lung Neoplasms surgery, Pulmonary Disease, Chronic Obstructive drug therapy, Scopolamine Derivatives therapeutic use
- Abstract
Objective: A new diagnosis of chronic obstructive pulmonary disease (COPD) is often made during the evaluation of patients requiring a surgical intervention for lung cancer. Based on initial impaired lung function, these untreated patients are often considered not fit for lung surgery. There is limited information on the short-term effectiveness of preoperative pharmacologic treatment strategies in patients with newly diagnosed COPD before lung surgery., Methods: A prospective randomized study was conducted comparing 1-week-treatment periods of tiotropium/formoterol/budenoside (GR1) with tiotropium/formoterol (GR2) in conjunction with smoking cessation and chest physiotherapy. No patients had been previously treated for COPD. The primary end point was body plethysmography (forced expiratory volume in 1s (FEV1), forced vital capacity (FVC), and airway resistance (RAW)) at the end of each treatment period. Secondary end points were improvement of ≥ 10% in FEV1 (% predicted) and improvement of the severity of COPD after the 1-week treatment, as well as the rate of pulmonary complications after surgery., Results: A total of 46 patients were randomized in GR1 (n=24) and GR2 (n=22). Both groups were comparable with regard to age, height, weight, smoking history, baseline body plethysmography (FVC, FEV1, and RAW), and the severity of COPD according to the Global Initiative for Obstructive Lung Disease (GOLD) staging, respectively. However, the short-term effects of the treatment with regard to FEV1 (2.0 l vs 1.7 l; p=0.031) and increase of FEV1 (0.31 l vs 0.10 l; p=0.02) were better in GR1. More patients in GR1 had an improvement of ≥ 10% in FEV1 (p=0.004) and improvement of the severity of COPD (p=0.012) after the 1-week treatment. Fewer pulmonary complications (11.1% vs 42.9%, p=0.04) were observed in GR1 after surgery., Conclusions: Both therapies resulted in an improvement of lung function. There is benefit from adding inhalative budenoside to tiotropium and formoterol in terms of an improvement in FEV1 and the severity of COPD. These beneficial results might lead to less pulmonary complications in the postoperative period., (Copyright © 2010 European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.