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51. ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma

Author

Jackson, Evangeline R., primary, Duchatel, Ryan J., additional, Staudt, Dilana E., additional, Persson, Mika L., additional, Mannan, Abdul, additional, Yadavilli, Sridevi, additional, Parackal, Sarah, additional, Game, Shaye, additional, Chong, Wai Chin, additional, Jayasekara, W. Samantha N., additional, Grand, Marion Le, additional, Kearney, Padraic S., additional, Douglas, Alicia M., additional, Findlay, Izac J., additional, Germon, Zacary P., additional, McEwen, Holly P., additional, Beitaki, Tyrone S., additional, Patabendige, Adjanie, additional, Skerrett-Byrne, David A., additional, Nixon, Brett, additional, Smith, Nathan D., additional, Day, Bryan, additional, Manoharan, Neevika, additional, Nagabushan, Sumanth, additional, Hansford, Jordan R., additional, Govender, Dinisha, additional, McCowage, Geoff B., additional, Firestein, Ron, additional, Howlett, Meegan, additional, Endersby, Raelene, additional, Gottardo, Nicholas G., additional, Alvaro, Frank, additional, Waszak, Sebastian M., additional, Larsen, Martin R., additional, Colino-Sanguino, Yolanda, additional, Valdes-Mora, Fatima, additional, Rakotomalala, Andria, additional, Meignan, Samuel, additional, Pasquier, Eddy, additional, André, Nicolas, additional, Hulleman, Esther, additional, Eisenstat, David D., additional, Vitanza, Nicholas A., additional, Nazarian, Javad, additional, Koschmann, Carl, additional, Mueller, Sabine, additional, Cain, Jason E., additional, and Dun, Matthew D., additional

Published
2023
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53. PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

Author

Duchatel, Ryan J, primary, Jackson, Evangeline R, additional, Parackal, Sarah G., additional, Sun, Claire, additional, Daniel, Paul, additional, Mannan, Abdul, additional, Findlay, Izac J, additional, Staudt, Dilana, additional, Germon, Zacary P, additional, Laternser, Sandra, additional, Kiltschewskij, Dylan, additional, Kearney, Padraic S, additional, Jamaluddin, Muhummad Fairuz B., additional, Douglas, Alicia M, additional, Beitaki, Tyrone, additional, Perrson, Mika, additional, Manning, Elizabeth E, additional, Murray, Heather C, additional, Verrills, Nicole M, additional, Skerrett-Byrne, David A, additional, Nixon, Brett, additional, Hua, Susan, additional, Valdes Mora, Fatima, additional, Tsoli, Maria, additional, Ziegler, David S, additional, Cairns, Murray J, additional, Raabe, Eric H, additional, Vitanza, Nicholas A, additional, Koschmann, Carl, additional, Alvaro, Frank, additional, Dayas, Christopher V, additional, Tinkle, Christopher, additional, Eisenstat, David, additional, Firestein, Ron, additional, Mueller, Sabine, additional, Nazarian, Javad, additional, Cain, Jason, additional, and Dun, Matthew D, additional

Published
2023
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54. Data from Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety

Author

Vitanza, Nicholas A., primary, Wilson, Ashley L., primary, Huang, Wenjun, primary, Seidel, Kristy, primary, Brown, Christopher, primary, Gustafson, Joshua A., primary, Yokoyama, Jason K., primary, Johnson, Adam J., primary, Baxter, Blake A., primary, Koning, Ryan W., primary, Reid, Aquene N., primary, Meechan, Michael, primary, Biery, Matthew C., primary, Myers, Carrie, primary, Rawlings-Rhea, Stephanie D., primary, Albert, Catherine M., primary, Browd, Samuel R., primary, Hauptman, Jason S., primary, Lee, Amy, primary, Ojemann, Jeffrey G., primary, Berens, Michael E., primary, Dun, Matthew D., primary, Foster, Jessica B., primary, Crotty, Erin E., primary, Leary, Sarah E.S., primary, Cole, Bonnie L., primary, Perez, Francisco A., primary, Wright, Jason N., primary, Orentas, Rimas J., primary, Chour, Tony, primary, Newell, Evan W., primary, Whiteaker, Jeffrey R., primary, Zhao, Lei, primary, Paulovich, Amanda G., primary, Pinto, Navin, primary, Gust, Juliane, primary, Gardner, Rebecca A., primary, Jensen, Michael C., primary, and Park, Julie R., primary

Published
2023
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58. Additional file 1 of Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection

Author

Staudt, Dilana E., Murray, Heather C., Skerrett-Byrne, David A., Smith, Nathan D., Jamaluddin, M. Fairuz B., Kahl, Richard G. S., Duchatel, Ryan J., Germon, Zacary P., McLachlan, Tabitha, Jackson, Evangeline R., Findlay, Izac J., Kearney, Padraic S., Mannan, Abdul, McEwen, Holly P., Douglas, Alicia M., Nixon, Brett, Verrills, Nicole M., and Dun, Matthew D.

Abstract

Additional file 1. Additional materials and methods. Figure S1. Standard spike-in control abundances (n = 3 biological replicates). Abundances for heavy-labeled spike-in peptides phosphorylated at tyrosine (Y), threonine (T), and serine (S) residues for FLT3-mutant cell lines. A Raw and B normalized peptide abundances of spike-in controls according to different FLT3 cell lines. Total SBDS C raw and D normalized protein abundances for FLT3-ITD, FLT3-ITD/D835V, and FLT3-ITD/D835Y cell lines.

Published
2023
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64. Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety

Author

Vitanza, Nicholas A., primary, Wilson, Ashley L., additional, Huang, Wenjun, additional, Seidel, Kristy, additional, Brown, Christopher, additional, Gustafson, Joshua A., additional, Yokoyama, Jason K., additional, Johnson, Adam J., additional, Baxter, Blake A., additional, Koning, Ryan W., additional, Reid, Aquene N., additional, Meechan, Michael, additional, Biery, Matthew C., additional, Myers, Carrie, additional, Rawlings-Rhea, Stephanie D., additional, Albert, Catherine M., additional, Browd, Samuel R., additional, Hauptman, Jason S., additional, Lee, Amy, additional, Ojemann, Jeffrey G., additional, Berens, Michael E., additional, Dun, Matthew D., additional, Foster, Jessica B., additional, Crotty, Erin E., additional, Leary, Sarah E.S., additional, Cole, Bonnie L., additional, Perez, Francisco A., additional, Wright, Jason N., additional, Orentas, Rimas J., additional, Chour, Tony, additional, Newell, Evan W., additional, Whiteaker, Jeffrey R., additional, Zhao, Lei, additional, Paulovich, Amanda G., additional, Pinto, Navin, additional, Gust, Juliane, additional, Gardner, Rebecca A., additional, Jensen, Michael C., additional, and Park, Julie R., additional

Published
2022
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65. Phospho heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection

Author

Staudt, Dilana E., primary, Murray, Heather C., additional, Skerrett-Byrne, David A., additional, Smith, Nathan D., additional, Jamaluddin, Muhammad F., additional, Kahl, Richard G.S., additional, Duchatel, Ryan J., additional, Germon, Zacary P., additional, McLachlan, Tabitha, additional, Jackson, Evangeline R., additional, Findlay, Izac J., additional, Kearney, Padraic S., additional, Mannan, Abdul, additional, McEwen, Holly P., additional, Douglas, Alicia M., additional, Nixon, Brett, additional, Verrills, Nicole M., additional, and Dun, Matthew D., additional

Published
2022
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66. B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers

Author

McLachlan, Tabitha, primary, Matthews, William C., additional, Jackson, Evangeline R., additional, Staudt, Dilana E., additional, Douglas, Alicia M., additional, Findlay, Izac J., additional, Persson, Mika L., additional, Duchatel, Ryan J., additional, Mannan, Abdul, additional, Germon, Zacary P., additional, and Dun, Matthew D., additional

Published
2022
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69. DIPG-07. Preclinical and case study results underpinning the phase II clinical trial testing the combination of ONC201 and paxalisib for the treatment of patients with diffuse midline glioma (NCT05009992)

Author

Dun, Matthew D, primary, Jackson, Evangeline R, additional, Duchatel, Ryan J, additional, Persson, Mika L, additional, Mannan, Abdul, additional, Yadavilli, Sridevi, additional, Parackal, Sarah, additional, Game, Shaye, additional, Chong, Wai Chin, additional, Jayasekara, Samantha, additional, Le Grand, Marion, additional, Kearney, Padraic S, additional, Douglas, Alicia M, additional, Findlay, Izac J, additional, Staudt, Dilana, additional, Germon, Zacary P, additional, Skerrett-Byrne, David A, additional, Nixon, Brett, additional, Smith, Nathan D, additional, Hulleman, Esther, additional, Day, Bryan, additional, McCowage, Geoff B, additional, Alvaro, Frank, additional, Waszak, Sebastian M, additional, Larsen, Martin R, additional, Colino-Sanguino, Yolanda, additional, Valdes-Mora, Fatima, additional, Rakotomalala, Andria, additional, Meignan, Samuel, additional, Pasquier, Eddy, additional, Vitanza, Nicholas A, additional, Nazarian, Javad, additional, Koschmann, Carl, additional, Cain, Jason, additional, and Mueller, Sabine, additional

Published
2022
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74. Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma

Author

Messinger, Dana, primary, Harris, Micah K, additional, Cummings, Jessica R, additional, Thomas, Chase, additional, Yang, Tao, additional, Sweha, Stefan R, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Burkert, Martin, additional, Stallard, Stefanie, additional, Qin, Tingting, additional, Mullan, Brendan, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Niculcea, Michael, additional, Dowling, Abigail R, additional, Bradin, Joshua, additional, Ginn, Kevin F, additional, Gener, Melissa A H, additional, Dorris, Kathleen, additional, Vitanza, Nicholas A, additional, Schmidt, Susanne V, additional, Spitzer, Jasper, additional, Li, Jiang, additional, Filbin, Mariella G, additional, Cao, Xuhong, additional, Castro, Maria G, additional, Lowenstein, Pedro R, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Desprez, Pierre-Yves, additional, McAllister, Sean, additional, Dun, Matthew D, additional, Hawkins, Cynthia, additional, Waszak, Sebastian M, additional, Venneti, Sriram, additional, Koschmann, Carl, additional, and Yadav, Viveka Nand, additional

Published
2022
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75. Seroreactivity to mucosa associated microbiota is associated with T cell gut‐homing in functional dyspepsia patients

Author

Burns, Grace L., primary, Hoedt, Emily C., additional, Jamaluddin, M Fairuz B., additional, Shanahan, Erin, additional, Lim, Yenkai, additional, Teh, Jing Jie, additional, Bruce, Jessica, additional, Almazi, Juhura, additional, Woldu, Ameha, additional, Dun, Matthew D., additional, Tanwar, Pradeep, additional, Potter, Michael, additional, Minahan, Kyra, additional, Horvat, Jay, additional, Foster, Paul S., additional, Holtmann, Gerald, additional, Veysey, Martin, additional, Walker, Marjorie M., additional, Morrison, Mark, additional, Talley, Nicholas J., additional, and Keely, Simon, additional

Published
2022
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76. 334: FUNCTIONAL DYSPEPSIA PATIENTS HAVE IGG ANTIBODIES AGAINST A NOVEL ISOLATE OF STREPTOCOCCUS SALIVARIUS

Author

Burns, Grace L., primary, Hoedt, Emily C., additional, Jamaluddin, M Fairuz, additional, Shanahan, Erin R., additional, Lim, Yenkai, additional, Teh, Jing Jie, additional, Bruce, Jessica K., additional, Almazi, Juhura, additional, Woldu, Ameha S., additional, Dun, Matthew D., additional, Tanwar, Pradeep, additional, Potter, Michael D., additional, Minahan, Kyra, additional, Horvat, Jay C., additional, Foster, Paul S., additional, Holtmann, Gerald, additional, Veysey, Martin, additional, Walker, Marjorie M., additional, Morrison, Mark, additional, Talley, Nicholas J., additional, and Keely, Simon, additional

Published
2022
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78. High-Throughput Global Phosphoproteomic Profiling Using Phospho Heavy-Labeled-Spiketide FAIMS Stepped-CV DDA (pHASED)

Author

Staudt, Dilana E., primary, Murray, Heather C., additional, Skerrett-Byrne, David A., additional, Smith, Nathan D., additional, Jamaluddin, Muhammad F., additional, Kahl, Richard G.S., additional, Duchatel, Ryan J., additional, Germon, Zacary, additional, McLachlan, Tabitha, additional, Jackson, Evangeline R., additional, Findlay, Izac J., additional, Kearney, Padraic S., additional, Mannan, Abdul, additional, McEwen, Holly P., additional, Douglas, Alicia M., additional, Nixon, Brett, additional, Verrills, Nicole M., additional, and Dun, Matthew D., additional

Published
2022
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80. Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies

Author

Germon, Zacary P., primary, Sillar, Jonathan R., additional, Mannan, Abdul, additional, Duchatel, Ryan J., additional, Staudt, Dilana, additional, Murray, Heather C., additional, Findlay, Izac J., additional, Jackson, Evangeline R., additional, McEwen, Holly P., additional, Douglas, Alicia M., additional, McLachlan, Tabitha, additional, Schjenken, John E., additional, Skerrett-Bryne, David A., additional, Huang, Honggang, additional, Melo-Braga, Marcella N., additional, Plank, Maximilian W., additional, Alvaro, Frank, additional, Chamberlain, Janis, additional, Iuliis, Geoff De, additional, Aitken, R. John, additional, Nixon, Brett, additional, Wei, Andrew H., additional, Enjeti, Anoop K., additional, Lock, Richard B., additional, Larsen, Martin R., additional, Lee, Heather, additional, de Bock, Charles E., additional, Verrills, Nicole M., additional, and Dun, Matthew D., additional

Published
2022
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82. Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

Author

Przystal, Justyna M, Cianciolo Cosentino, Chiara, Yadavilli, Sridevi, Zhang, Jie, Laternser, Sandra, Bonner, Erin R, Prasad, Rachna, Dawood, Adam A, Lobeto, Nina, Chin Chong, Wai, Biery, Matt C, Myers, Carrie, Olson, James M, Panditharatna, Eshini, Kritzer, Bettina, Mourabit, Sulayman, Vitanza, Nicholas A, Filbin, Mariella G, de Iuliis, Geoffry N, Dun, Matthew D, Koschmann, Carl, Cain, Jason E, Grotzer, Michael A, Waszak, Sebastian M, Mueller, Sabine, Nazarian, Javad, and University of Zurich

Subjects
Cancer Research, Pyridines, Imidazoles, 610 Medicine & health, Antineoplastic Agents, Glioma, Heterocyclic Compounds, 4 or More Rings, Mice, 2728 Neurology (clinical), Pyrimidines, Oncology, 10036 Medical Clinic, Cell Line, Tumor, Basic and Translational Investigations, Animals, Humans, 2730 Oncology, 1306 Cancer Research, Cell Lineage, Neurology (clinical), Child, Energy Metabolism, Zebrafish
Abstract

Background Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not been fully described in DMGs. Methods DMG models including primary human in vitro (n = 18) and in vivo (murine and zebrafish) models, and patient (n = 20) frozen and FFPE specimens were used. Drug-target engagement was evaluated using in silico ChemPLP and in vitro thermal shift assay. Drug toxicity and neurotoxicity were assessed in zebrafish models. Seahorse XF Cell Mito Stress Test, MitoSOX and TMRM assays, and electron microscopy imaging were used to assess metabolic signatures. Cell lineage differentiation and drug-altered pathways were defined using bulk and single-cell RNA-seq. Results ONC201 and ONC206 reduce viability of DMG cells in nM concentrations and extend survival of DMG PDX models (ONC201: 117 days, P = .01; ONC206: 113 days, P = .001). ONC206 is 10X more potent than ONC201 in vitro and combination treatment was the most efficacious at prolonging survival in vivo (125 days, P = .02). Thermal shift assay confirmed that both drugs bind to ClpP, with ONC206 exhibiting a higher binding affinity as assessed by in silico ChemPLP. ClpP activation by both drugs results in impaired tumor cell metabolism, mitochondrial damage, ROS production, activation of integrative stress response (ISR), and apoptosis in vitro and in vivo. Strikingly, imipridone treatment triggered a lineage shift from a proliferative, oligodendrocyte precursor-like state to a mature, astrocyte-like state. Conclusion Targeting mitochondrial metabolism and ISR activation effectively impairs DMG tumorigenicity. These results supported the initiation of two pediatric clinical trials (NCT05009992, NCT04732065).

Published
2022

83. Su1632 A NOVEL ISOLATE OF STREPTOCOCCUS SALIVARIUS, AGIRA0003, DISRUPTS TIGHT JUNCTIONS EX VIVO IN FUNCTIONAL DYSPEPSIA.

Author

Burns, Grace L., Wark, Jasmine A., Hoedt, Emily C., Minahan, Kyra, Sherwin, Simonne, Bruce, Jessica K., Lim, Yenkai, Teh, Jing Jie, Jamaluddin, M Fairuz, Soh, Wai Sinn, Caban, Shandelle, Almazi, Juhura, Woldu, Ameha S., Dun, Matthew D., Potter, Michael D., Shanahan, Erin R., Holtmann, Gerald J., Walker, Marjorie M., Morrison, Mark, Talley, Nicholas J., and Keely, Simon

Published
2024
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84. Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas

Author

Przystal, Justyna M, primary, Cianciolo Cosentino, Chiara, additional, Yadavilli, Sridevi, additional, Zhang, Jie, additional, Laternser, Sandra, additional, Bonner, Erin R, additional, Prasad, Rachna, additional, Dawood, Adam A, additional, Lobeto, Nina, additional, Chin Chong, Wai, additional, Biery, Matt C, additional, Myers, Carrie, additional, Olson, James M, additional, Panditharatna, Eshini, additional, Kritzer, Bettina, additional, Mourabit, Sulayman, additional, Vitanza, Nicholas A, additional, Filbin, Mariella G, additional, de Iuliis, Geoffry N, additional, Dun, Matthew D, additional, Koschmann, Carl, additional, Cain, Jason E, additional, Grotzer, Michael A, additional, Waszak, Sebastian M, additional, Mueller, Sabine, additional, and Nazarian, Javad, additional

Published
2022
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90. Time‐resolved proteomic profiling of cigarette smoke‐induced experimental chronic obstructive pulmonary disease

Author

Skerrett‐Byrne, David A., primary, Bromfield, Elizabeth G., additional, Murray, Heather C., additional, Jamaluddin, M. Fairuz B., additional, Jarnicki, Andrew G., additional, Fricker, Michael, additional, Essilfie, Ama T., additional, Jones, Bernadette, additional, Haw, Tatt J., additional, Hampsey, Daniel, additional, Anderson, Amanda L., additional, Nixon, Brett, additional, Scott, Rodney J., additional, Wark, Peter A. B., additional, Dun, Matthew D., additional, and Hansbro, Philip M., additional

Published
2021
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93. Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

Author

Duchatel, Ryan J, Mannan, Abdul, Woldu, Ameha S, Hawtrey, Tom, Hindley, Phoebe A, Douglas, Alicia M, Jackson, Evangeline R, Findlay, Izac J, Germon, Zacary P, Staudt, Dilana, Kearney, Padraic S, Smith, Nathan D, Hindley, Kate E, Cain, Jason E, André, Nicolas, La Madrid, Andres Morales, Nixon, Brett, De Iuliis, Geoffry N, Nazarian, Javad, Irish, Kathleen, Alvaro, Frank, Eisenstat, David D, Beck, Alexander, Vitanza, Nicholas A, Mueller, Sabine, Morris, Jonathan C ; https://orcid.org/0000-0002-5109-9069, Dun, Matthew D, Duchatel, Ryan J, Mannan, Abdul, Woldu, Ameha S, Hawtrey, Tom, Hindley, Phoebe A, Douglas, Alicia M, Jackson, Evangeline R, Findlay, Izac J, Germon, Zacary P, Staudt, Dilana, Kearney, Padraic S, Smith, Nathan D, Hindley, Kate E, Cain, Jason E, André, Nicolas, La Madrid, Andres Morales, Nixon, Brett, De Iuliis, Geoffry N, Nazarian, Javad, Irish, Kathleen, Alvaro, Frank, Eisenstat, David D, Beck, Alexander, Vitanza, Nicholas A, Mueller, Sabine, Morris, Jonathan C ; https://orcid.org/0000-0002-5109-9069, and Dun, Matthew D

Abstract

Background. Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem tumor for which radiation is the only treatment. Case studies report a clinical response to ONC201 for patients with H3K27M-mutant gliomas. Oncoceutics (ONC201) is only available in the United States and Japan; however, in Germany, DIPG patients can be prescribed and dispensed a locally produced compound-ONC201 German-sourced ONC201 (GsONC201). Pediatric oncologists face the dilemma of supporting the administration of GsONC201 as conjecture surrounds its authenticity.Therefore, we compared GsONC201 to original ONC201 manufactured by Oncoceutics Inc. Methods. Authenticity of GsONC201 was determined by high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Biological activity was shown via assessment of on-target effects, in vitro growth, proliferation, and apoptosis analysis. Patient-derived xenograft mouse models were used to assess plasma and brain tissue pharmacokinetics, pharmacodynamics, and overall survival (OS). The clinical experience of 28 H3K27M+ mutant DIPG patients who received GsONC201 (2017-2020) was analyzed. Results. GsONC201 harbored the authentic structure, however, was formulated as a free base rather than the dihydrochloride salt used in clinical trials. GsONC201 in vitro and in vivo efficacy and drug bioavailability studies showed no difference compared to Oncoceutics ONC201. Patients treated with GsONC201 (n = 28) showed a median OS of 18 months (P = .0007). GsONC201 patients who underwent reirradiation showed a median OS of 22 months compared to 12 months for GsONC201 patients who did not (P = .012). Conclusions. This study confirms the biological activity of GsONC201 and documents the OS of patients who received the drug; however, GsONC201 was never used as a monotherapy.

Published
2021

94. A novel role for milk fat globule‐EGF factor 8 protein (MFGE8) in the mediation of mouse sperm–extracellular vesicle interactions

Author

Trigg, Natalie A., primary, Stanger, Simone J., additional, Zhou, Wei, additional, Skerrett‐Byrne, David A., additional, Sipilä, Petra, additional, Dun, Matthew D., additional, Eamens, Andrew L., additional, De Iuliis, Geoffry N., additional, Bromfield, Elizabeth G., additional, Roman, Shaun D., additional, and Nixon, Brett, additional

Published
2021
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97. Post-testicular sperm maturation in the saltwater crocodile Crocodylus porosus: assessing the temporal acquisition of sperm motility

Author

Nixon, Brett, primary, Anderson, Amanda L., additional, Bromfield, Elizabeth G., additional, Martin, Jacinta H., additional, Cafe, Shenae L., additional, Skerrett-Byrne, David A., additional, Dun, Matthew D., additional, Eamens, Andrew L., additional, De Iuliis, Geoffry N., additional, and Johnston, Stephen D., additional

Published
2021
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98. Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

Author

Duchatel, Ryan J, primary, Mannan, Abdul, additional, Woldu, Ameha S, additional, Hawtrey, Tom, additional, Hindley, Phoebe A, additional, Douglas, Alicia M, additional, Jackson, Evangeline R, additional, Findlay, Izac J, additional, Germon, Zacary P, additional, Staudt, Dilana, additional, Kearney, Padraic S, additional, Smith, Nathan D, additional, Hindley, Kate E, additional, Cain, Jason E, additional, André, Nicolas, additional, La Madrid, Andres Morales, additional, Nixon, Brett, additional, De Iuliis, Geoffry N, additional, Nazarian, Javad, additional, Irish, Kathleen, additional, Alvaro, Frank, additional, Eisenstat, David D, additional, Beck, Alexander, additional, Vitanza, Nicholas A, additional, Mueller, Sabine, additional, Morris, Jonathan C, additional, and Dun, Matthew D, additional

Published
2021
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100. DIPG-29. PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE (PI3K) INHIBITION DRIVES PROTEIN KINASE C ACTIVATION (PKC) IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Author

Duchatel, Ryan J, primary, Mannan, Abdul, additional, Jackson, Evangeline R, additional, Staudt, Dilana, additional, Skerrett-Byrne, David A, additional, Jamaluddin, M Fairuz B, additional, Woldu, Ameha S, additional, Douglas, Alicia, additional, Hulleman, Esther, additional, Carcaboso, Angel M, additional, Monje, Michelle, additional, Alvaro, Frank, additional, Tsoli, Maria, additional, Ziegler, David S, additional, and Dun, Matthew D, additional

Published
2020
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