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662 results on '"Du, Lina"'

51. Integration of Gut Microbiota, Serum Metabolomic, and Network Pharmacology to Reveal the Anti Insomnia Mechanism of Mongolian Medicine Sugemule-4 Decoction on Insomnia Model Rats

Author

Du,Lina, Yang,Dezhi, Wu,Lan, Mei,Li, Wu,Sarula, Ba,Yasula, Bao,Yongchang, Su,Rigugaqiqige, Song,Lin, Du,Lina, Yang,Dezhi, Wu,Lan, Mei,Li, Wu,Sarula, Ba,Yasula, Bao,Yongchang, Su,Rigugaqiqige, and Song,Lin

Abstract

Lina Du,1 Dezhi Yang,2 Lan Wu,1 Li Mei,1 Sarula Wu,1 Yasula Ba,1 Yongchang Bao,1 Rigugaqiqige Su,1 Lin Song1 1College of Mongolian Medical, Inner Mongolia Medical University, Hohhot, Inner Mongolia, People’s Republic of China; 2Innovative Mongolian Medical Engineering Research Center, Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, People’s Republic of ChinaCorrespondence: Lin Song, Inner Mongolia Medical University, Tel +15849163188, Email songlinwpsword@163.comObjective: To explored the potential molecular mechanism of Sugemule-4 decoction (MMS-4D) in treating insomnia.Methods: DL-4-chlorophenylalanine (PCPA) + chronic unpredictable mild stress stimulation (CUMS) was used to induce an insomnia model in rats. After the model was successfully established, MMS-4D was intervened at low, medium, and high doses for 7 days. The open-field test (OFT) was used to preliminarily evaluate the efficacy. The potential mechanism of MMS-4D in treating insomnia was investigated using gut microbiota, serum metabolomics, and network pharmacology (NP). Experimental validation of the main components of the key pathways was carried out using ELISA and Western blot.Results: The weights of the insomnia-model rats were significantly raised (p ≤ 0.05), the total exercise distance in the OFT increased (p ≤ 0.05), the rest time shortened, and the number of standing times increased (p ≤ 0.05), after treatment with MMS-4D. Moreover, there was a substantial recovery in the 5-HT, DA, GABA, and Glu levels in the hypothalamus tissue and the 5-HT and GABA levels in the colon tissue of rats. The expression of DAT and DRD1 proteins in the hippocampus of insomnia rats reduced after drug treatment. MMS-4D may treat insomnia by regulating different crucial pathways including 5-HT -, DA -, GABA -, and Glu-mediated neuroactive light receiver interaction, cAMP signaling pathway, serotonergic, glutamatergic, dopaminergic, and GABAergic synapses.Conclusion: This study revea

Published
2024

52. Heterogeneous photocatalytic synthesis of sulfenamides with carbon doped potassium poly(heptazine imide) through effective electron delocalization.

Author

Yuan, Fei, Zhang, Leilei, Jiang, Haohao, Zhou, Yannan, Yin, Hang, Zhu, Tianjing, Yang, Baocheng, Zhang, Shouren, Ma, Junying, and Du, Lina

Subjects
ELECTRON delocalization, COUPLING reactions (Chemistry), DOPING agents (Chemistry), NEAR infrared radiation, ELECTRON density
Abstract

Sulfur–heteroatom bonds, such as S–N bonds, are valuable motifs in pharmaceuticals and agrochemicals, but the creation of new green synthetic methods to construct these compounds via rational design of catalysts remains challenging. Hence, we report an environmentally benign photocatalytic S–N coupling reaction between thiols and amines over carbon-doped potassium poly(heptazine imide), resulting in the synthesis of sulfenamides. Encouragingly, after optimizing the C-doping content of potassium poly(heptazine imide), we can achieve high sulfenamide conversion rates of 92% (10 W white LED, 24 h) and 86% (real sunlight irradiation in summer, 5 h). Moreover, the present catalyst possesses good substrate tolerance for the photocatalytic S–N coupling of thiols and amine derivatives, great recyclability, and a gram-scale synthesis was also possible. We provide good evidence that the carbon-doping of potassium poly(heptazine imide) can extend its optical absorption range to near-infrared light while inhibiting the intrinsic radiative recombination of photoexcited electron–hole pairs and facilitating the single electron transfer process owing to its delocalized electron density. Overall, boosting the photosynthetic sulfenamide activity by introducing delocalized electrons is demonstrated, and this could be applied more widely in heterogeneous photocatalysis in organic synthesis. [ABSTRACT FROM AUTHOR]

Published
2024
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69. Decisions Tree Learning Method Based on Three-Way Decisions

Author

Liu, Yangyang, Xu, Jiucheng, Sun, Lin, Du, Lina, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Yao, Yiyu, editor, Hu, Qinghua, editor, Yu, Hong, editor, and Grzymala-Busse, Jerzy W., editor

Published
2015
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76. MPLA-Net: Multiple Pseudo Label Aggregation Network for Weakly Supervised Video Salient Object Detection

Author

Ma, Chunjie, Du, Lina, Zhuo, Li, and Li, Jiafeng

Abstract

Weakly Supervised Video Salient Object Detection (WSVSOD) only requires coarse-grained manual annotations, which can achieve a good trade-off between labeling efficiency and detection performance. In this paper, a Multiple Pseudo Label Aggregation Network (MPLA-Net) is proposed for WSVSOD. Firstly, the video frames that can obtain high-quality pseudo labels are selected to generate multiple pseudo labels, so as to avoid the prejudice of the single label. Moreover, the pseudo label with fine edge information is used to generate the Edge Information Map (EIM). Secondly, MPLA-Net is designed to adequately excavate and utilize the comprehensive saliency cues in multiple pseudo labels to improve the detection accuracy, in which ResNet-50 is adopted as the backbone network. Edge loss, pseudo label loss, self-supervised loss and fusion loss are exploited to jointly supervise and optimize the network training to obtain a robust detection model. Experimental results on five benchmark datasets demonstrate that, compared with existing weakly supervised methods, the proposed method can achieve state-of-the-art detection accuracy with less model parameters and higher detection speed. And the detected salient objects have fine boundaries.

Published
2024
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85. Injectable Multifunctional Polysaccharide-Based Hydrogel Accelerates Wound Healing in Combined Radiation and Burn Injury

Author

Du, Lina, primary, Shen, Jintao, additional, Jiao, Wencheng, additional, Chen, Ziyuan, additional, Wang, Chunqing, additional, Song, Xingshuang, additional, Ma, Lei, additional, Tang, Ziyan, additional, Yan, Wenrui, additional, Xie, Hua, additional, Yuan, Bochuan, additional, Wang, Chenyun, additional, Dai, Jing, additional, Sun, Yunbo, additional, and Jin, Yiguang, additional

Published
2023
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