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4,322 results on '"Doi, T."'

62. 113P Pembrolizumab in microsatellite instability-high (MSI-H)/mismatch repair deficient (dMMR) advanced solid tumors: An update of the phase II KEYNOTE-158 trial

Author

Maio, M., primary, Ascierto, P.A., additional, Motola Kuba, D., additional, Penel, N., additional, Cassier, P.A., additional, Bariani, G.M., additional, De Jesus-Acosta, A., additional, Doi, T., additional, Longo Muñoz, F., additional, Miller, W.H., additional, Oh, D-Y., additional, Gottfried, M., additional, Yao, L., additional, Jin, F.J., additional, Gozman, A., additional, and Marabelle, A., additional

Published
2022
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63. 453O DS-7300 (B7-H3 DXd antibody-drug conjugate [ADC]) shows durable antitumor activity in advanced solid tumors: Extended follow-up of a phase I/II study

Author

Doi, T., primary, Patel, M., additional, Falchook, G.S., additional, Koyama, T., additional, Friedman, C.F., additional, Piha-Paul, S., additional, Gutierrez, M.E., additional, Abdul-Karim, R., additional, Awad, M., additional, Adkins, D.R., additional, Takahashi, S., additional, Kadowaki, S., additional, Cheng, B., additional, Ikeda, N., additional, Laadem, A., additional, Yoshizuka, N., additional, Qian, M., additional, Dosunmu, O., additional, Arkenau, H-T., additional, and Johnson, M.L., additional

Published
2022
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74. Entitäten-unabhängige Sicherheit und Wirksamkeit von Erdafitinib bei Patienten mit fortgeschrittenen soliden Tumoren mit präspezifizierten genomischen FGFR- Aberrationen (RAGNAR Interimanalyse)

Author

Schuler, Martin, Loriot, Y., Iyer, G., Witt, O., Doi, T., Qin, S., Tabernero, J., Reardon, D. A., Massard, C., Palmer, D. H., Lugowska, I., Coward, J., Corassa, M., Stuyckens, K., Liao, H., Najmi, S., Hammond, C., Santiago-Walker, A. E., Sweiti, H., and Pant, S.

Subjects
Medizin
Published
2022

75. Probing $ΞN$ interaction through inversion of spin-doublets in $ΞN αα$ nuclei

Author

Hiyama, E., Isaka, M., Doi, T., and Hatsuda, T.

Subjects
Nuclear Theory (nucl-th), FOS: Physical sciences, Nuclear Experiment (nucl-ex)
Abstract

A new way to study the spin-isospin dependence of the $ΞN$ interaction is explored through the energy levels of $ΞNα$ and $ΞNαα$ systems with $α$ being a spectator to attract the $ ΞN$ pair without changing its spin-isospin structure. By using the Gaussian expansion method (GEM) with the state-of-the-art $ΞN$ potential obtained from lattice QCD calculations, it is found that $ΞNαα$ has spin-doublet bound states with $J^π={1^-}$ and $2^-$ in both isospin triplet and singlet channels. The inversion of the $1^-$-$2^-$ spin-doublet between the iso-triplet and the iso-singlet is found to be strongly correlated with the relative strengths of the $ΞN$ interaction in the $^{11}{\rm S}_0, ^{13}{\rm S}_1,^{31}{\rm S}_0$ and $^{33}{\rm S}_1$ channels. The $(K^-, K^+)$ and $(K^-,K^0)$ reactions on the $^{10}$B target are proposed to produce those bound states., 5pages, 5figures

Published
2022
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77. Cognitive function affects trainability for physical performance in exercise intervention among older adults with mild cognitive impairment

Author

Uemura K, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, and Suzuki T

Subjects
Exercise, Mobility, Rehabilitation, Timed Up & Go Test, Geriatrics, RC952-954.6
Abstract

Kazuki Uemura,1,3 Hiroyuki Shimada,1 Hyuma Makizako,1,3 Takehiko Doi,1 Daisuke Yoshida,1 Kota Tsutsumimoto,1 Yuya Anan,1 Takao Suzuki21Section for Health Promotion, Department for Research and Development to Support Independent Life of Elderly, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 2Research Institute, National Center for Geriatrics and Gerontology, Aichi, 3Japan Society for the Promotion of Science, Tokyo, JapanBackground: Although much evidence supports the hypothesis that cognitive function and physical function are interrelated, it is unclear whether cognitive decline with mild cognitive impairment influences trainability of physical performance in exercise intervention. The purpose of this study was to examine the association between cognitive function at baseline and change in physical performance after exercise intervention in older adults with mild cognitive impairment.Methods: Forty-four older adults diagnosed with mild cognitive impairment based on the Peterson criteria (mean age 74.8 years) consented to and completed a 6-month twice weekly exercise intervention. The Timed Up and Go (TUG) test was used as a measure of physical performance. The Mini-Mental State Examination (MMSE), Trail Making Test Part B, Geriatric Depression Scale, baseline muscle strength of knee extension, and attendance rate of intervention, were measured as factors for predicting trainability.Results: In the correlation analysis, the change in TUG showed modest correlations with attendance rate in the exercise program (r = -0.354, P = 0.027) and MMSE at baseline (r = -0.321, P = 0.034). A multiple regression analysis revealed that change in TUG was independently associated with attendance rate (ß = -0.322, P = 0.026) and MMSE score (ß = -0.295, P = 0.041), controlling for age and gender.Conclusion: General cognitive function was associated with improvements in physical performance after exercise intervention in subjects with mild cognitive impairment. Further research is needed to examine the effects of exercise programs designed to address cognitive obstacles in older adults with mild cognitive impairment.Keywords: exercise, mobility, rehabilitation, Timed Up and Go test

Published
2013

80. A case of traumatic intracranial vertebral artery injury presenting with life-threatening symptoms

Author

Kishi S, Kanaji K, Doi T, and Matsumura T

Subjects
Medicine (General), R5-920
Abstract

Seiji Kishi1, Kenji Kanaji2, Toshio Doi1, Tadashi Matsumura21Department of Nephrology, Tokushima University Hospital, Kuramoto-cho Tokushima, 2Department of General Internal Medicine, Rakuwakai Otowa Hospital, Otowachinji-cho Yamashina-ku Kyoto, JapanAbstract: Traumatic intracranial vertebral artery injury is a relatively rare but potentially fatal disease. We present a case of a 63-year-old man who presented with sudden onset of loss of consciousness after hitting his head. After immediate resuscitation, he showed quadriplegia and absence of spontaneous breathing. Brain and cervical spine magnetic resonance imaging revealed an atlantoaxial subluxation, fractured C2 odontoid process, left vertebral artery occlusion, and bilateral extensive ischemia in the medulla oblongata and high cervical spinal cord. Digital subtraction angiography demonstrated left vertebral artery dissection just below the level of vertebral body C2.Keywords: vertebral artery dissection, brainstem infarction, bilateral spinal cord infarction, neck trauma

Published
2012

84. Candidates for the 5 Condensed State in Ne

Author

Adachi, S., Fujikawa, Y., Kawabata, T., Akimune, H., Doi, T., Furuno, T., Harada, T., Inaba, K., Ishida, S., Itoh, M., Iwamoto, C., Kobayashi, N., Maeda, Y., Matsuda, Y., Murata, M., Okamoto, S., Sakaue, A., Sekiya, R., Tamii, A., and Tsumura, M.

Abstract

We conducted the coincidence measurement of α particles inelastically scattered from $^{20}$Ne at 0° and decay charged particles in order to search for the alpha-particle condensed state. We compared the measured excitation-energy spectrum and decay branching ratio with the statistical-decay-model calculations, and found that the newly observed states at Ex=23.6, 21.8, and 21.2 MeV in $^{20}$Ne are strongly coupled to a candidate for the 4α condensed state in $^{16}$O. This result presents the first strong evidence that these states are the candidates for the 5α condensed state.

Published
2021

85. Candidates for the 5α condensed state in ²⁰Ne

Author

Adachi, S., Fujikawa, Y., Kawabata, T., Akimune, H., Doi, T., Furuno, T., Harada, T., Inaba, K., Ishida, S., Itoh, M., Iwamoto, C., Kobayashi, N., Maeda, Y., Matsuda, Y., Murata, M., Okamoto, S., Sakaue, A., Sekiya, R., Tamii, A., and Tsumura, M.

Subjects
²⁰Ne, Alpha-particle condensed state, Alpha decay, Inelastic alpha scattering, Cluster structure
Abstract

We conducted the coincidence measurement of α particles inelastically scattered from ²⁰Ne at 0° and decay charged particles in order to search for the alpha-particle condensed state. We compared the measured excitation-energy spectrum and decay branching ratio with the statistical-decay-model calculations, and found that the newly observed states at , Ex = 23.6, 21.8, and 21.2 MeV in ²⁰Ne are strongly coupled to a candidate for the 4α condensed state in ¹⁶O. This result presents the first strong evidence that these states are the candidates for the 5α condensed state., ネオン20原子核の新しい存在形態の発見 --低密度原子核物質の解明に向けて--. 京都大学プレスリリース. 2021-06-15.

Published
2021

87. Candidates for the 5α condensed state in 20Ne

Author

Adachi, S., Fujikawa, Y., Kawabata, T., Akimune, H., Doi, T., Furuno, T., Harada, T., Inaba, K., Ishida, S., Itoh, M., Iwamoto, C., Kobayashi, N., Maeda, Y., Matsuda, Y., Murata, M., Okamoto, S., Sakaue, A., Sekiya, R., Tamii, A., and Tsumura, M.

Published
2021
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94. 545P First-in-human (FIH) study of E7130 in patients (pts) with advanced solid tumors: Primary result of dose-escalation part

Author

Doi, T., primary, Matsubara, N., additional, Naito, Y., additional, Kuboki, Y., additional, Harano, K., additional, Ono, M., additional, Urasaki, T., additional, Ohmoto, A., additional, Hisai, T., additional, Mikubo, A., additional, Ikezawa, H., additional, Shiba, S., additional, Ito, K., additional, Asano, O., additional, and Takahashi, S., additional

Published
2021
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96. 554P Phase I clinical trial of OBP-301, a novel telomerase-specific oncolytic virus, in combination with radiotherapy in esophageal cancer patients

Author

Tanabe, S., primary, Kojima, T., additional, Tazawa, H., additional, Noma, K., additional, Katsui, K., additional, Hori, K., additional, Nakamura, N., additional, Urata, Y., additional, Doi, T., additional, Kanazawa, S., additional, Shirakawa, Y., additional, Fujiwara, T., additional, and Okada, H., additional

Published
2021
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97. Clinical usefulness of a novel fluorescence technique for the intraoperative diagnosis of surgical margins in patients with breast cancer

Author

Ueo, H, primary, Ueo, H, additional, Minoura, I, additional, Gamachi, A, additional, Doi, T, additional, Yamaguchi, M, additional, Yamashita, T, additional, Tsuda, H, additional, Moriya, T, additional, Yamaguchi, R, additional, Kozuka, Y, additional, Sasaki, T, additional, Masuda, T, additional, Kai, Y, additional, Kubota, Y, additional, Urano, Y, additional, Mori, M, additional, and Mimori, K, additional

Published
2021
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99. SO-8 Health-related quality of life in patients treated with pembrolizumab for microsatellite instability-high/mismatch repair deficient advanced solid tumors: Results from the KEYNOTE-158 study

Author

Maio, M., primary, Amonkar, M., additional, Norquist, J., additional, Ascierto, P., additional, Manzyuk, L., additional, Motola-Kuba, D., additional, Penel, N., additional, Cassier, P., additional, Bariani, G., additional, De Jesus Acosta, A., additional, Doi, T., additional, Muñoz, F., additional, Miller, W., additional, Oh, D., additional, Gottfried, M., additional, Wang, R., additional, Norwood, K., additional, and Marabelle, A., additional

Published
2021
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