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Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered to be drug-induced diseases, and are characterized by extensive mucocutaneous disorder and epidermal necrosis which result in the detachment of the epidermis. Inactive and active forms of metalloproteinases (MMP2 and MMP9) secreted by skin explants maintained in organ culture for 72 h and in blister fluid from two TEN and three SJS patients were investigated. Interestingly, lesional skin from both the TEN and the SJS patients cultured for 3 days in conditioned medium showed high levels of both 72 kDa progelatinase A and 66 kDa activated gelatinase A, and the 66 kDa activated form was not observed in cultures of skin from control individuals. Furthermore, indirect immunodetection showed the presence of MMP2 and MMP9 in TEN and SJS patients' skin. Increased gelatinase activity in the culture medium of TEN and SJS skin maintained in organ culture and in blister fluid indicates that these gelatinases may be responsible for the detachment of the epidermis in these drug-induced necrolyses. [ABSTRACT FROM AUTHOR]

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

L’utilisation des gels plaquettaires en tant qu’adjuvants chirurgicaux est encore très récente, et elle souffre du manque d’investigations sérieuses quant à leurs propriétés biologiques. Ce constat met en évidence la nécessité de protocoles d’analyse rationalisés, reproductibles et fiables des résultats obtenus par adjonction de ces préparations. Face à l’absence totale de travaux sur le PRF (Platelet-Rich Fibrin), dont l’action sur le guidage du remodelage osseux est en théorie plus importante que celle d’une simple colle biologique à base de fibrine (cPRP : concentrated Platelet-Rich Plasma), nous avons entrepris une étude histologique de prélèvements osseux issus d’une série de neuf comblements de sinus réalisés avec de l’os allogénique Phœnix de TBF®, avec ou sans PRF. Après quatre mois de maturation, le tissu osseux greffé avec PRF a fini par acquérir une architecture quasiment superposable à celle obtenue à huit mois sans PRF. De plus, les quantités d’os néoformé sont équivalentes entre les deux protocoles. Ces résultats nous permettent d’envisager la diminution du temps de maturation des greffons avant implantation et la réalisation de greffes à l’aide de prélèvements osseux moins importants grâce à l’ajout de PRF. [Copyright &y& Elsevier]

Le bistouri ultrasonore permet de réaliser avec une extrême précision et une grande sécurité un grand nombre de chirurgies orales et maxillo-faciales. Cependant, c’est au cours de quatre types d’interventions bien particuliers que cet outil présentera des performances réellement supérieures à l’instrumentation conventionnelle : la dépose non traumatique d’implants ostéo-intégrés, les prélèvements symphysaires et rétromolaires et la latéralisation du nerf alvéolaire inférieur. L’objectif de cet article est de présenter en détail chacune de ces quatre applications et d’en discuter les avantages et les inconvénients par rapport aux techniques antérieures. En effet, le bistouri piézoélectrique permet de simplifier considérablement ces protocoles chirurgicaux grâce à des incisions peu délabrantes et un clivage des interfaces solides, sous l’effet des ultrasons, qui favorise la rupture des fragments osseux. [Copyright &y& Elsevier]

Le bistouri ultrasonore est un instrument capable de découper avec précision les tissus durs et de faciliter le clivage des interfaces solides. Pour cela, il utilise des microvibrations de moyenne fréquence générées par un transducteur piézoélectrique et appliquées à des inserts durcis au nitrure de titane et/ou diamantés. Grâce à sa vaste gamme d’inserts, il trouve de nombreuses applications en chirurgie orale et maxillofaciale, qu’il s’agisse d’avulsions dentaires non traumatiques, de surfaçages radiculaires et débridements de poches parodontales, ou encore de curetages de kystes. Il propose également un protocole simplifié pour la réalisation des sinus-lifts. Enfin, il offre une vraie révolution dans la chirurgie de greffe osseuse en permettant la découpe précise et non traumatique des greffons. Cet article en présente les aspects physiques, technologiques et cliniques et entame une discussion sur ses applications les plus prometteuses. Car s’il demeure un outil sécurisant et performant dans de nombreuses circonstances, il est cependant important de lui définir un champ d’application raisonné. [Copyright &y& Elsevier]

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Implantodontie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The absolute K-conversion coefficients of the 496 keV-124 keV cascade γ-rays inCs have been determined from angular correlation experiments using a new approach. The value of α=0.0100±0.0007 obtained for the 496 keV transition is in excellent agreement with the theory whereas a strong case is presented for the existence of an anomalous nuclear-structure-dependent conversion coefficient for the 124 keV transition. The K-conversion coefficient for this transition has been measured to be 0.742±0.077 giving a value of 1.25±0.13 for the ratio α/ α. The result is interpreted as being due to the presence of electric monopole, E0, electron transition. A value of 0.26±0.14 has been obtained for the E0/ E2 electron conversion ratio and the absolute value of the electric monopole matrix element has been determined to be 0.07±0.02. [ABSTRACT FROM AUTHOR]

Objective: To assess the effect of a practice-level preoperative frailty screening and optimization toolkit (OPTI-Surg) on postoperative functional recovery and complications in elderly cancer patients undergoing major surgery., Background: Frailty is common in older adults. It increases the risk of poor postoperative functional recovery and complications. The potential for a practice-level screening/optimization intervention to improve outcomes is unknown., Methods: Thoracic, gastrointestinal, and urologic oncological surgery practices within the National Cancer Institute Community Oncology Research Program (NCORP) were randomized 1:1:1 to usual care (UC), OPTI-Surg, or OPTI-Surg with an implementation coach. OPTI-Surg consisted of the Edmonton Frail Scale and guided recommendations for referral interventions. Patients 70 years old or above undergoing curative intent surgery were eligible. The primary outcome was 8 weeks postoperative function (kcal/wk). The key secondary outcome was complications within 90 days. Mixed models were used to compare UC to the 2 OPTI-Surg arms combined., Results: From July 2019 to September 2022, 325 patients were enrolled in 29 practices. One hundred ninety-nine (64 UC, 135 OPTI-Surg) and 279 (78 UC, 201 OPTI-Surg) were evaluable for primary and secondary analysis, respectively. UC and OPTI-Surg patients did not significantly differ in total caloric expenditure (2.2 UC, 2.0 OPTI-Surg) after adjusting for baseline function ( P =0.53). UC and OPTI-Surg patients did not significantly differ in postoperative complications (25.6% UC, 35.3% OPTI-Surg, P =0.5)., Conclusions: Frailty assessment was successfully performed, but the OPTI-Surg intervention did not improve postoperative function nor reduce postoperative complications compared with UC. Future analysis will explore practice-level factors associated with toolkit implementation and the differences between the coaching and noncoaching arms., Competing Interests: E.F. is a founding shareholder of Ooney. The remaining authors report no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Importance: People with Alzheimer's disease (AD) now have access to disease-modifying treatment with anti-amyloid monoclonal antibodies (mAbs). Their perception of risks and benefits and approach to treatment decisions remain unknown., Objective: To understand how people with early AD consider benefits and costs of anti-amyloid mAbs and make decisions about treatment., Design: Qualitative semi-structured interviews., Setting: Memory care clinics at two academic medical centers., Participants: People with biomarker or imaging-confirmed early AD referred for evaluation for treatment with anti-amyloid mAbs., Main Outcomes and Measures: Themes identified through content analysis., Results: Among 22 participants, mean age was 70 years, 8 (36%) were women, 22 (100%) were White, 8 (36%) had less than a college degree, 11 (50%) had annual income less than $100,000, and 6 (27%) lived in a rural area. The analysis revealed 3 major themes and associated subthemes: 1) People with AD sought and obtained information from different sources-advocacy organizations, the Internet, and clinicians; 2) hopes, expected benefits, and the existential threat of dementia drove willingness and readiness to start lecanemab-hopes included more time feeling like themselves and doing enjoyable activities; expected benefits included stalling progression, reversing cognitive decline or cure; 3) individual traits and preferences, family factors, and degree of trust in expertise influenced how people balanced risks and benefits- some would accept treatment at any cost; others carefully weighed risks and burdens carefully, but were motivated to pursue treatment by supportive families, insurance coverage, and trust in expertise; for a few, costs decidedly outweighed their personal benefits. People with AD desired more individualized information on risks and benefits and wanted to hear more from patients who took the medication., Conclusions and Relevance: Results from this qualitative analysis inform clinician, health system and policy efforts to promote individualized treatment decisions for anti-amyloid mAb treatment through multimodal education and outreach, evidence-based communication skills, and adaptation of similar care models., Key Points: Question: How do people with Alzheimer's disease (AD) decide on treatment with newly available anti-amyloid monoclonal antibodies? Findings: In this qualitative analysis, people with AD considering treatment relied on multiple information sources; were motivated by hope to delay cognitive decline and preserve independence; and worried side effects would impair quality of life. Personality traits, family support, and trust in expertise determined how they balanced these tradeoffs. People with AD wanted more personalized information and to hear from others who had taken the medications. Meaning: As access to treatment expands, these findings inform how clinicians can help people with AD make individualized treatment decisions.

Objective: Responsive and human-centered neurotechnology development requires attention to public perceptions, particularly among groups underserved by existing treatments., Methods: The authors conducted a preregistered nationally representative survey (https://osf.io/ej9h2) using the NORC at the University of Chicago AmeriSpeak panel. One vignette compared an implanted neural device with surgical resection in a scenario involving epilepsy, and another compared an implanted neural device with medications in a scenario involving mood disorders. The survey also contained questions about respondents' confidence that a device would be available if needed and confidence that enough research has been conducted among people like themselves. Responses were entered into nested survey-weighted logistic regression models, including a base demographic model (to test the overall effect of demographic factors) and an adjusted model that also included socioeconomic, religious and political, and health care access predictors., Results: A total of 1,047 adults responded to the survey, which oversampled Black non-Hispanic (N=214), Hispanic (N=210), and rural (N=219) Americans. In the base demographic model, older Americans were more likely to prefer an implanted device in the two scenarios, and non-Hispanic Black Americans were less likely than non-Hispanic White Americans to prefer a device; rural Americans were less confident than urban or suburban Americans in having access, and non-Hispanic Black and rural Americans were less confident that enough research has been conducted among people like themselves. In adjusted models, income was a key mediator, partially explaining the effect of age and the contrast between Black and White non-Hispanic respondents on preferences for a device in the epilepsy scenario and fully explaining the effect of rurality on confidence in access., Conclusions: Demographic differences in prospective preferences and concerns highlight the importance of including members of underserved communities in neurotechnology development., Competing Interests: The authors report no financial relationships with commercial interests.

Importance: Timely diagnosis and treatment are of paramount importance for patients with head and neck cancer (HNC) because delays are associated with reduced survival rates and increased recurrence risk. Prompt referral to HNC specialists is crucial for the timeliness of care, yet the factors that affect the referral and triage pathway remain relatively unexplored. Therefore, to identify barriers and facilitators of timely care, it is important to understand the complex journey that patients undertake from the onset of HNC symptoms to referral for diagnosis and treatment., Objective: To investigate the referral and triage process for patients with HNC and identify barriers to and facilitators of care from the perspectives of patients and health care workers., Design, Participants, and Setting: This was a qualitative study using semistructured interviews of patients with HNC and health care workers who care for them. Participants were recruited from June 2022 to July 2023 from HNC clinics at 2 tertiary care academic medical centers in Boston, Massachusetts. Data were analyzed from July 2022 to December 2023., Main Outcomes and Measures: Themes identified from the perspectives of both patients and health care workers on factors that hinder or facilitate the HNC referral and triage process., Results: In total, 72 participants were interviewed including 42 patients with HNC (median [range] age, 60.5 [19.0-81.0] years; 27 [64%] females) and 30 health care workers (median [range] age, 38.5 [20.0-68.0] years; 23 [77%] females). Using thematic analysis, 4 major themes were identified: the HNC referral and triage pathway is fragmented; primary and dental care are critical for timely referrals; efficient interclinician coordination expedites care; and consistent patient-practitioner engagement alleviates patient fear., Conclusions and Relevance: These findings describe the complex HNC referral and triage pathway, emphasizing the critical role of initial symptom recognition, primary and dental care, patient information flow, and interclinician and patient-practitioner communication, all of which facilitate prompt HNC referrals.