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53. Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes

Author

Kohaar, Indu, Zhang, Xijun, Tan, Shyh-Han, Nousome, Darryl, Babcock, Kevin, Ravindranath, Lakshmi, Sukumar, Gauthaman, Mcgrath-Martinez, Elisa, Rosenberger, John, Alba, Camille, Ali, Amina, Young, Denise, Chen, Yongmei, Cullen, Jennifer, Rosner, Inger L., Sesterhenn, Isabell A., Dobi, Albert, Chesnut, Gregory, Turner, Clesson, Dalgard, Clifton, Wilkerson, Matthew D., Pollard, Harvey B., Srivastava, Shiv, and Petrovics, Gyorgy

Published
2022
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56. Low correlation between Ki67 assessed by qRT-PCR in Oncotype Dx score and Ki67 assessed by Immunohistochemistry

Author

Zohair Selmani, Chloé Molimard, Alexis Overs, Fernando Bazan, Loic Chaigneau, Erion Dobi, Nathalie Meneveau, Laura Mansi, Marie-Justine Paillard, Guillaume Meynard, Julien Viot, Marie-Paule Algros, Christophe Borg, Jean-Paul Feugeas, Xavier Pivot, Jean-Luc Prétet, and Elsa Curtit

Subjects
Medicine, Science
Abstract

Abstract Breast cancers expressing high levels of Ki67 are associated with poor outcomes. Oncotype DX test was designed for ER+/HER2− early-stage breast cancers to help adjuvant chemotherapy decision by providing a Recurrent Score (RS). RS measures the expression of 21 specific genes from tumor tissue, including Ki67. The primary aim of this study was to assess the agreement between Ki67RNA obtained with Oncotype DX RS and Ki67IHC. Other objectives were to analyze the association between the event free survival (EFS) and the expression level of Ki67RNA; and association between RS and Ki67RNA. Herein, we report a low agreement of 0.288 by Pearson correlation coefficient test between Ki67IHC and Ki67RNA in a cohort of 98 patients with early ER+/HER2− breast cancers. Moreover, Ki67RNA high tumors were significantly associated with the occurrence of events (p = 0.03). On the other hand, we did not find any association between Ki67IHC and EFS (p = 0.26). We observed a low agreement between expression level of Ki67RNA and Ki67 protein labelling by IHC. Unlike Ki67IHC and independently of the RS, Ki67RNA could have a prognostic value. It would be interesting to better assess the prognosis and predictive value of Ki67RNA measured by qRT-PCR. The Ki67RNA in medical routine could be a good support in countries where Oncotype DX is not accessible.

Published
2022
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57. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author

D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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58. Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes

Author

Indu Kohaar, Xijun Zhang, Shyh-Han Tan, Darryl Nousome, Kevin Babcock, Lakshmi Ravindranath, Gauthaman Sukumar, Elisa Mcgrath-Martinez, John Rosenberger, Camille Alba, Amina Ali, Denise Young, Yongmei Chen, Jennifer Cullen, Inger L. Rosner, Isabell A. Sesterhenn, Albert Dobi, Gregory Chesnut, Clesson Turner, Clifton Dalgard, Matthew D. Wilkerson, Harvey B. Pollard, Shiv Srivastava, and Gyorgy Petrovics

Subjects
Science
Abstract

DNA damage repair genes have been linked with increased aggressiveness of prostate cancer, however, the extent of mutation of these genes has not been analyzed within a cohort of African American patients. Here, the authors identify increased mutation rates in specific DNA repair genes, compared with prostate cancer patients with European Ancestry.

Published
2022
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59. Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression

Author

William Gesztes, Cara Schafer, Denise Young, Jesse Fox, Jiji Jiang, Yongmei Chen, Huai-Ching Kuo, Kuwong B. Mwamukonda, Albert Dobi, Allen P. Burke, Judd W. Moul, David G. McLeod, Inger L. Rosner, Gyorgy Petrovics, Shyh-Han Tan, Jennifer Cullen, Shiv Srivastava, and Isabell A. Sesterhenn

Subjects
Medicine, Science
Abstract

Abstract TP53 is one of the most frequently altered genes in prostate cancer. The precise assessment of its focal alterations in primary tumors by immunohistochemistry (IHC) has significantly enhanced its prognosis. p53 protein expression and lymphovascular invasion (LVI) were evaluated for predicting metastatic progression by IHC staining of representative whole-mounted prostate sections from a cohort of 189 radical prostatectomy patients with up to 20 years of clinical follow-up. Kaplan–Meier survival curves were used to examine time to distant metastasis (DM) as a function of p53 expression and LVI status. TP53 targeted sequencing was performed in ten tumors with the highest expression of p53 staining. Nearly half (49.8%) of prostate tumors examined showed focal p53 expression while 26.6% showed evidence of LVI. p53(+) tumors had higher pathologic T stage, Grade Group, Nuclear Grade, and more frequent LVI. p53 expression of > 5% and LVI, individually and jointly, are associated with poorer DM-free survival. TP53 mutations were detected in seven of ten tumors sequenced. Four tumors with the highest p53 expression harbored likely pathogenic or pathogenic mutations. High levels of p53 expression suggest the likelihood of pathogenic TP53 alterations and, together with LVI status, could enhance early prognostication of prostate cancer progression.

Published
2022
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61. Position Reconstruction in LUX

Author

LUX Collaboration, Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Druszkiewicz, E., Edwards, B. N., Fallon, S. R., Fan, A., Fiorucci, S., Gaitskell, R. J., Genovesi, J., Ghag, C., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Velan, V., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Physics - Computational Physics
Abstract

The $(x, y)$ position reconstruction method used in the analysis of the complete exposure of the Large Underground Xenon (LUX) experiment is presented. The algorithm is based on a statistical test that makes use of an iterative method to recover the photomultiplier tube (PMT) light response directly from the calibration data. The light response functions make use of a two dimensional functional form to account for the photons reflected on the inner walls of the detector. To increase the resolution for small pulses, a photon counting technique was employed to describe the response of the PMTs. The reconstruction was assessed with calibration data including ${}^{\mathrm{83m}}$Kr (releasing a total energy of 41.5 keV) and ${}^{3}$H ($\beta^-$ with Q = 18.6 keV) decays, and a deuterium-deuterium (D-D) neutron beam (2.45 MeV). In the horizontal plane, the reconstruction has achieved an $(x, y)$ position uncertainty of $\sigma$= 0.82 cm for events of only 200 electroluminescence photons and $\sigma$ = 0.17 cm for 4,000 electroluminescence photons. Such signals are associated with electron recoils of energies $\sim$0.25 keV and $\sim$10 keV, respectively. The reconstructed position of the smallest events with a single electron emitted from the liquid surface has a horizontal $(x, y)$ uncertainty of 2.13 cm., Comment: 30 pages, 17 figures

Published
2017
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62. Ultra-Low Energy Calibration of LUX Detector using $^{127}$Xe Electron Capture

Author

LUX Collaboration, Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Druszkiewicz, E., Edwards, B. N., Fallon, S. R., Fan, A., Fiorucci, S., Gaitskell, R. J., Genovesi, J., Ghag, C., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Velan, V., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

We report an absolute calibration of the ionization yields($\textit{Q$_y$})$ and fluctuations for electronic recoil events in liquid xenon at discrete energies between 186 eV and 33.2 keV. The average electric field applied across the liquid xenon target is 180 V/cm. The data are obtained using low energy $^{127}$Xe electron capture decay events from the 95.0-day first run from LUX (WS2013) in search of Weakly Interacting Massive Particles (WIMPs). The sequence of gamma-ray and X-ray cascades associated with $^{127}$I de-excitations produces clearly identified 2-vertex events in the LUX detector. We observe the K- (binding energy, 33.2 keV), L- (5.2 keV), M- (1.1 keV), and N- (186 eV) shell cascade events and verify that the relative ratio of observed events for each shell agrees with calculations. The N-shell cascade analysis includes single extracted electron (SE) events and represents the lowest-energy electronic recoil $\textit{in situ}$ measurements that have been explored in liquid xenon., Comment: 10 pages, 10 figures, 2 tables

Published
2017
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63. 3D Modeling of Electric Fields in the LUX Detector

Author

LUX Collaboration, Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Druszkiewicz, E., Edwards, B. N., Fallon, S. R., Fan, A., Fiorucci, S., Gaitskell, R. J., Genovesi, J., Ghag, C., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Velan, V., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Physics - Computational Physics
Abstract

This work details the development of a three-dimensional (3D) electric field model for the LUX detector. The detector took data during two periods of searching for weakly interacting massive particle (WIMP) searches. After the first period completed, a time-varying non-uniform negative charge developed in the polytetrafluoroethylene (PTFE) panels that define the radial boundary of the detector's active volume. This caused electric field variations in the detector in time, depth and azimuth, generating an electrostatic radially-inward force on electrons on their way upward to the liquid surface. To map this behavior, 3D electric field maps of the detector's active volume were built on a monthly basis. This was done by fitting a model built in COMSOL Multiphysics to the uniformly distributed calibration data that were collected on a regular basis. The modeled average PTFE charge density increased over the course of the exposure from -3.6 to $-5.5~\mu$C/m$^2$. From our studies, we deduce that the electric field magnitude varied while the mean value of the field of $\sim200$~V/cm remained constant throughout the exposure. As a result of this work the varying electric fields and their impact on event reconstruction and discrimination were successfully modeled.

Published
2017
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64. $^{83\textrm{m}}$Kr calibration of the 2013 LUX dark matter search

Author

LUX Collaboration, Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Druszkiewicz, E., Edwards, B. N., Fallon, S. R., Fan, A., Fiorucci, S., Gaitskell, R. J., Genovesi, J., Ghag, C., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Velan, V., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

LUX was the first dark matter experiment to use a $^{83\textrm{m}}$Kr calibration source. In this paper we describe the source preparation and injection. We also present several $^{83\textrm{m}}$Kr calibration applications in the context of the 2013 LUX exposure, including the measurement of temporal and spatial variation in scintillation and charge signal amplitudes, and several methods to understand the electric field within the time projection chamber.

Published
2017
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65. Limits on spin-dependent WIMP-nucleon cross section obtained from the complete LUX exposure

Author

LUX Collaboration, Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fallon, S. R., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Velan, V., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present experimental constraints on the spin-dependent WIMP-nucleon elastic cross sections from the total 129.5 kg-year exposure acquired by the Large Underground Xenon experiment (LUX), operating at the Sanford Underground Research Facility in Lead, South Dakota (USA). A profile likelihood ratio analysis allows 90% CL upper limits to be set on the WIMP-neutron (WIMP-proton) cross section of $\sigma_n$ = 1.6$\times 10^{-41}$ cm$^{2}$ ($\sigma_p$ = 5$\times 10^{-40}$ cm$^{2}$) at 35 GeV$c^{-2}$, almost a sixfold improvement over the previous LUX spin-dependent results. The spin-dependent WIMP-neutron limit is the most sensitive constraint to date., Comment: 7 pages, 3 figures, version accepted by PRL

Published
2017
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66. First Searches for Axions and Axion-Like Particles with the LUX Experiment

Author

Akerib, D. S., Alsum, S., Aquino, C., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fallon, S. R., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Velan, V., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

The first searches for axions and axion-like particles with the Large Underground Xenon (LUX) experiment are presented. Under the assumption of an axio-electric interaction in xenon, the coupling constant between axions and electrons, gAe is tested, using data collected in 2013 with an exposure totalling 95 live-days $\times$ 118 kg. A double-sided, profile likelihood ratio statistic test excludes gAe larger than 3.5 $\times$ 10$^{-12}$ (90% C.L.) for solar axions. Assuming the DFSZ theoretical description, the upper limit in coupling corresponds to an upper limit on axion mass of 0.12 eV/c$^{2}$, while for the KSVZ description masses above 36.6 eV/c$^{2}$ are excluded. For galactic axion-like particles, values of gAe larger than 4.2 $\times$ 10$^{-13}$ are excluded for particle masses in the range 1-16 keV/c$^{2}$. These are the most stringent constraints to date for these interactions.

Published
2017
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67. LUX-ZEPLIN (LZ) Technical Design Report

Author

Mount, B. J., Hans, S., Rosero, R., Yeh, M., Chan, C., Gaitskell, R. J., Huang, D. Q., Makkinje, J., Malling, D. C., Pangilinan, M., Rhyne, C. A., Taylor, W. C., Verbus, J. R., Kim, Y. D., Lee, H. S., Lee, J., Leonard, D. S., Li, J., Belle, J., Cottle, A., Lippincott, W. H., Markley, D. J., Martin, T. J., Sarychev, M., Tope, T. E., Utes, M., Wang, R., Young, I., Araújo, H. M., Bailey, A. J., Bauer, D., Colling, D., Currie, A., Fayer, S., Froborg, F., Greenwood, S., Jones, W. G., Kasey, V., Khaleeq, M., Olcina, I., Paredes, B. López, Richards, A., Sumner, T. J., Tomás, A., Vacheret, A., Brás, P., Lindote, A., Lopes, M. I., Neves, F., Rodrigues, J. P., Silva, C., Solovov, V. N., Barry, M. J., Cole, A., Dobi, A., Edwards, W. R., Faham, C. H., Fiorucci, S., Gantos, N. J., Gehman, V. M., Gilchriese, M. G. D., Hanzel, K., Hoff, M. D., Kamdin, K., Lesko, K. T., McConnell, C. T., O'Sullivan, K., Oliver-Mallory, K. C., Patton, S. J., Saba, J. S., Sorensen, P., Thomas, K. J., Tull, C. E., Waldron, W. L., Witherell, M. S., Bernstein, A., Kazkaz, K., Xu, J., Akimov, D. Yu., Bolozdynya, A. I., Khromov, A. V., Konovalov, A. M., Kumpan, A. V., Sosnovtsev, V. V., Dahl, C. E., Temples, D., Carmona-Benitez, M. C., de Viveiros, L., Akerib, D. S., Auyeung, H., Biesiadzinski, T. P., Breidenbach, M., Bramante, R., Conley, R., Craddock, W. W., Fan, A., Hau, A., Ignarra, C. M., Ji, W., Krebs, H. J., Linehan, R., Lee, C., Luitz, S., Mizrachi, E., Monzani, M. E., O'Neill, F. G., Pierson, S., Racine, M., Ratcliff, B. N., Shutt, G. W., Shutt, T. A., Skarpaas, K., Stifter, K., To, W. H., Va'vra, J., Whitis, T. J., Wisniewski, W. J., Bai, X., Bunker, R., Coughlen, R., Hjemfelt, C., Leonard, R., Miller, E. H., Morrison, E., Reichenbacher, J., Schnee, R. W., Stark, M. R., Sundarnath, K., Tiedt, D. R., Timalsina, M., Bauer, P., Carlson, B., Horn, M., Johnson, M., Keefner, J., Maupin, C., Taylor, D. J., Balashov, S., Ford, P., Francis, V., Holtom, E., Khazov, A., Kaboth, A., Majewski, P., Nikkel, J. A., O'Dell, J., Preece, R. M., van der Grinten, M. G. D., Worm, S. D., Mannino, R. L., Stiegler, T. M., Terman, P. A., Webb, R. C., Levy, C., Mock, J., Szydagis, M., Busenitz, J. K., Elnimr, M., Hor, J. Y-K., Meng, Y., Piepke, A., Stancu, I., Kreczko, L., Krikler, B., Penning, B., Bernard, E. P., Jacobsen, R. G., McKinsey, D. N., Watson, R., Cutter, J. E., El-Jurf, S., Gerhard, R. M., Hemer, D., Hillbrand, S., Holbrook, B., Lenardo, B. G., Manalaysay, A. G., Morad, J. A., Stephenson, S., Thomson, J. A., Tripathi, M., Uvarov, S., Haselschwardt, S. J., Kyre, S., Nehrkorn, C., Nelson, H. N., Solmaz, M., White, D. T., Cascella, M., Dobson, J. E. Y., Ghag, C., Liu, X., Manenti, L., Reichhart, L., Shaw, S., Utku, U., Beltrame, P., Davison, T. J. R., Marzioni, M. F., Murphy, A. St. J., Nilima, A., Boxer, B., Burdin, S., Greenall, A., Powell, S., Rose, H. J., Sutcliffe, P., Balajthy, J., Edberg, T. K., Hall, C. R., Silk, J. S., Hertel, S., Akerlof, C. W., Arthurs, M., Lorenzon, W., Pushkin, K., Schubnell, M., Boast, K. E., Carels, C., Fruth, T., Kraus, H., Liao, F. -T., Lin, J., Scovell, P. R., Druszkiewicz, E., Khaitan, D., Koyuncu, M., Skulski, W., Wolfs, F. L. H., Yin, J., Korolkova, E. V., Kudryavtsev, V. A., Rossiter, P., Woodward, D., Chiller, A. A., Chiller, C., Mei, D. -M., Wang, L., Wei, W. -Z., While, M., Zhang, C., Alsum, S. K., Benson, T., Carlsmith, D. L., Cherwinka, J. J., Dasu, S., Gregerson, G., Gomber, B., Pagac, A., Palladino, K. J., Vuosalo, C. O., Xiao, Q., Buckley, J. H., Bugaev, V. V., Olevitch, M. A., Boulton, E. M., Emmet, W. T., Hurteau, T. W., Larsen, N. A., Pease, E. K., Tennyson, B. P., and Tvrznikova, L.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

In this Technical Design Report (TDR) we describe the LZ detector to be built at the Sanford Underground Research Facility (SURF). The LZ dark matter experiment is designed to achieve sensitivity to a WIMP-nucleon spin-independent cross section of three times ten to the negative forty-eighth square centimeters., Comment: 392 pages. Submitted to the Department of Energy as part of the documentation for the Critical Decision Numbers Two and Three (CD-2 and CD-3) management processes. Report also available by chapter at this URL

Published
2017

68. Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches

Author

Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alsum, S. K., Araújo, H. M., Arnquist, I. J., Arthurs, M., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Barry, M. J., Belle, J., Beltrame, P., Benson, T., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boast, K. E., Bolozdynya, A., Boxer, B., Bramante, R., Brás, P., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Cottle, A., Coughlen, R., Craddock, W. W., Currie, A., Dahl, C. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edberg, T. K., Edwards, W. R., Emmet, W. T., Faham, C. H., Fiorucci, S., Fruth, T., Gaitskell, R. J., Gantos, N. J., Gehman, V. M., Gerhard, R. M., Ghag, C., Gilchriese, M. G. D., Gomber, B., Hall, C. R., Hans, S., Hanzel, K., Haselschwardt, S. J., Hertel, S. A., Hillbrand, S., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hoppe, E. W., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Jacobsen, R. G., Ji, W., Kaboth, A., Kamdin, K., Kazkaz, K., Khaitan, D., Khazov, A., Khromov, A. V., Konovalov, A. M., Korolkova, E. V., Koyuncu, M., Kraus, H., Krebs, H. J., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lee, C., Lee, H. S., Lee, J., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Liao, F. -T., Lin, J., Lindote, A., Linehan, R. E., Lippincott, W. H., Liu, X., Lopes, M. I., Paredes, B. Lopez, Lorenzon, W., Luitz, S., Majewski, P., Manalaysay, A., Manenti, L., Mannino, R. L., Markley, D. J., Martin, T. J., Marzioni, M. F., McConnell, C. T., McKinsey, D. N., Mei, D. -M., Meng, Y., Miller, E. H., Mizrachi, E., Mock, J., Monzani, M. E., Morad, J. A., Mount, B. J., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., Nikkel, J. A., O'Dell, J., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Piepke, A., Powell, S., Preece, R. M., Pushkin, K., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Saba, J. S., Sarychev, M., Schnee, R. W., Schubnell, M., Scovell, P. R., Shaw, S., Shutt, T. A., Silva, C., Skarpaas, K., Skulski, W., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stiegler, T. M., Stifter, K., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Temples, D., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tvrznikova, L., Va'vra, J., Vacheret, A., van der Grinten, M. G. D., Verbus, J. R., Vuosalo, C. O., Waldron, W. L., Wang, R., Watson, R., Webb, R. C., Wei, W. -Z., While, M., White, D. T., Whitis, T. J., Wisniewski, W. J., Witherell, M. S., Wolfs, F. L. H., Woodward, D., Worm, S., Xu, J., Yeh, M., Yin, J., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a detector containing a total of 10 tonnes of liquid xenon within a double-vessel cryostat. The large mass and proximity of the cryostat to the active detector volume demand the use of material with extremely low intrinsic radioactivity. We report on the radioassay campaign conducted to identify suitable metals, the determination of factors limiting radiopure production, and the selection of titanium for construction of the LZ cryostat and other detector components. This titanium has been measured with activities of $^{238}$U$_{e}$~$<$1.6~mBq/kg, $^{238}$U$_{l}$~$<$0.09~mBq/kg, $^{232}$Th$_{e}$~$=0.28\pm 0.03$~mBq/kg, $^{232}$Th$_{l}$~$=0.25\pm 0.02$~mBq/kg, $^{40}$K~$<$0.54~mBq/kg, and $^{60}$Co~$<$0.02~mBq/kg (68\% CL). Such low intrinsic activities, which are some of the lowest ever reported for titanium, enable its use for future dark matter and other rare event searches. Monte Carlo simulations have been performed to assess the expected background contribution from the LZ cryostat with this radioactivity. In 1,000 days of WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute only a mean background of $0.160\pm0.001$(stat)$\pm0.030$(sys) counts., Comment: 13 pages, 3 figures, accepted for publication in Astroparticle Physics

Published
2017
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69. A korai laboratóriumi vizsgálatok jelentősége hűtött asphyxiás újszülöttek kezelésében.

Author

Kovács, Kata, Pászthy-Szabó, Benedek, Dobi, Marianna, Kerekes, Ramóna, and Jermendy, Ágnes

Abstract

Copyright of Hungarian Medical Journal / Orvosi Hetilap is the property of Akademiai Kiado and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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70. A novel ryanodine receptor 2 inhibitor, M201‐A, enhances natriuresis, renal function and lusi‐inotropic actions: Preclinical and phase I study.

Author

Kaneko, Noboru, Loughrey, Christopher M., Smith, Godfrey, Matsuda, Ryuko, Hasunuma, Tomoko, Mark, Patric B., Toda, Masashi, Shinozaki, Makoto, Otani, Naoyuki, Kayley, Scott, Da Silva Costa, Ana, Martin, Tamara P., Dobi, Sara, Saxena, Priyanka, Shimamoto, Ken, Ishikawa, Tetsuya, Kambayashi, Ryuichi, Riddell, Alexandra, Elliott, Elspeth B., and McCarroll, Charlotte S.

Subjects
KIDNEY physiology, GLOMERULAR filtration rate, CHRONIC kidney failure, HEART cells, CALCIUM ions, RYANODINE receptors
Abstract

Background and Purpose: The ryanodine receptor 2 (RyR2) is present in both the heart and kidneys, and plays a crucial role in maintaining intracellular Ca2+ homeostasis in cells in these organs. This study aimed to investigate the impact of M201‐A on RyR2, as well as studying its effects on cardiac and renal functions in preclinical and clinical studies. Experimental Approach: Following the administration of M201‐A (1,4‐benzothiazepine‐1‐oxide derivative), we monitored diastolic Ca2+ leak via RyR2 and intracellular Ca2+ concentration in isolated rat cardiomyocytes and in cardiac and renal function in animals. In a clinical study, M201‐A was administered intravenously at doses of 0.2 and 0.4 mg·kg−1 once daily for 20 min for four consecutive days in healthy males, with the assessment of haemodynamic responses. Key Results: In rat heart cells, M201‐A effectively inhibited spontaneous diastolic Ca2+ leakage through RyR2 and exhibited positive lusi‐inotropic effects on the rat heart. Additionally, it enhanced natriuresis and improved renal function in dogs. In human clinical studies, when administered intravenously, M201‐A demonstrated an increase in natriuresis, glomerular filtration rate and creatinine clearance, while maintaining acceptable levels of drug safety and tolerability. Conclusions and Implications: The novel drug M201‐A inhibited diastolic Ca2+ leak via RyR2, improved cardiac lusi‐inotropic effects in rats, and enhanced natriuresis and renal function in humans. These findings suggest that this drug may offer a potential new treatment option for chronic kidney disease and heart failure. [ABSTRACT FROM AUTHOR]

Published
2024
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71. Liquid xenon scintillation measurements and pulse shape discrimination in the LUX dark matter detector

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Druszkiewicz, E, Edwards, BN, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Lenardo, BG, Lesko, KT, Liao, J, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, DM, Mock, J, Moongweluwan, M, Morad, JA, Murphy, ASJ, Nehrkorn, C, Nelson, HN, Neves, F, O'Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Utku, U, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
physics.ins-det
Abstract

Weakly interacting massive particles (WIMPs) are a leading candidate for dark matter and are expected to produce nuclear recoil (NR) events within liquid xenon time-projection chambers. We present a measurement of the scintillation timing characteristics of liquid xenon in the LUX dark matter detector and develop a pulse shape discriminant to be used for particle identification. To accurately measure the timing characteristics, we develop a template-fitting method to reconstruct the detection times of photons. Analyzing calibration data collected during the 2013-2016 LUX WIMP search, we provide a new measurement of the singlet-to-triplet scintillation ratio for electron recoils (ER) below 46 keV, and we make, to our knowledge, a first-ever measurement of the NR singlet-to-triplet ratio at recoil energies below 74 keV. We exploit the difference of the photon time spectra for NR and ER events by using a prompt fraction discrimination parameter, which is optimized using calibration data to have the least number of ER events that occur in a 50% NR acceptance region. We then demonstrate how this discriminant can be used in conjunction with the charge-to-light discrimination to possibly improve the signal-to-noise ratio for nuclear recoils.

Published
2018

72. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ

Author

Vasquez, Joshua J, Hussien, Rajaa, Aguilar-Rodriguez, Brandon, Junger, Henrik, Dobi, Dejan, Henrich, Timothy J, Thanh, Cassandra, Gibson, Erica, Hogan, Louise E, McCune, Joseph, Hunt, Peter W, Stoddart, Cheryl A, and Laszik, Zoltan G

Subjects
Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Biotechnology, Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, Genetics, Infection, DNA, Viral, Fluorescent Antibody Technique, HIV, HIV Infections, Humans, In Situ Hybridization, Paraffin Embedding, RNA, Viral, Single-Cell Analysis, Tissue Fixation, Viral Load, HIV reservoir, quantitative image analysis, tissue fixation, Medical and Health Sciences, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry
Abstract

Persistent tissue reservoirs of HIV present a major barrier to cure. Defining subsets of infected cells in tissues is a major focus of HIV cure research. Herein, we describe a novel multiplexed in situ hybridization (ISH) (RNAscope) protocol to detect HIV-DNA (vDNA) and HIV-RNA (vRNA) in formalin-fixed paraffin-embedded (FFPE) human tissues in combination with immunofluorescence (IF) phenotyping of the infected cells. We show that multiplexed IF and ISH (mIFISH) is suitable for quantitative assessment of HIV vRNA and vDNA and that multiparameter IF phenotyping allows precise identification of the cellular source of the ISH signal. We also provide semi-quantitative data on the impact of various tissue fixatives on the detectability of vDNA and vRNA with RNAscope technology. Finally, we describe methods to quantitate the ISH signal on whole-slide digital images and validation of the quantitative ISH data with quantitative real-time PCR for vRNA. It is our hope that this approach will provide insight into the biology of HIV tissue reservoirs and to inform strategies aimed at curing HIV.

Published
2018

73. Calibration, event reconstruction, data analysis, and limit calculation for the LUX dark matter experiment

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Cahn, SB, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Dobson, JEY, Druszkiewicz, E, Edwards, BN, Faham, CH, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Gehman, VM, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lee, C, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, D-M, Mock, J, Moongweluwan, M, Morad, JA, St. J. Murphy, A, Nehrkorn, C, Nelson, HN, Neves, F, O’Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Reichhart, L, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Affordable and Clean Energy, physics.ins-det
Abstract

The LUX experiment has performed searches for dark-matter particles scattering elastically on xenon nuclei, leading to stringent upper limits on the nuclear scattering cross sections for dark matter. Here, for results derived from 1.4×104 kg days of target exposure in 2013, details of the calibration, event-reconstruction, modeling, and statistical tests that underlie the results are presented. Detector performance is characterized, including measured efficiencies, stability of response, position resolution, and discrimination between electron- and nuclear-recoil populations. Models are developed for the drift field, optical properties, background populations, the electron- and nuclear-recoil responses, and the absolute rate of low-energy background events. Innovations in the analysis include in situ measurement of the photomultipliers' response to xenon scintillation photons, verification of fiducial mass with a low-energy internal calibration source, and new empirical models for low-energy signal yield based on large-sample, in situ calibrations.

Published
2018

74. Targeted Transcriptional Profiling of Kidney Transplant Biopsies

Author

Sigdel, Tara K, Nguyen, Mark, Dobi, Dejan, Hsieh, Szu-Chuan, Liberto, Juliane M, Vincenti, Flavio, Sarwal, Minnie M, and Laszik, Zoltan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Biotechnology, Renal and urogenital, FFPE, gene expression, kidney transplant, nanostring, QPCR, rejection, Biomedical and clinical sciences, Health sciences
Abstract

IntroductionStudies are needed to assess the quality of transcriptome analysis in paired human tissue samples preserved by different methods and different gene amplification platforms to enable data comparisons across experimenters.MethodsRNA was extracted from kidney biopsies, either submerged in RNA-stabilizing solution (RSS) or stored in formalin-fixed, paraffin-embedded (FFPE) blocks. RNA quality and integrity were compared. Gene expression of the common rejection module and other immune cell genes were quantified for both tissue preservation methods in the same sample using conventional quantitative polymerase chain reaction (QPCR) by 2 different commercial platforms, (fluidigm [FD]) or barcoded-oligos (nanostring [NS]).ResultsRNA quality was inferior in FFPE tissues. Despite this, gene expression for 19 measured genes on the same sample, stored in FFPE or RSS, were strongly correlated on the FD (r = 0.81) or NS platforms (r = 0.82). For the same samples, interplatform gene expression correlations were excellent (r = 0.80) for RSS and moderate (r = 0.66) for FFPE. Significant differences in gene expression were confirmed on both platforms (FD: P = 1.1E-03; NS: P = 2.5E-04) for biopsy-confirmed acute rejection.ConclusionOur study provided supportive evidence that despite a low RNA quality of archival FFPE kidney transplantation tissue, small quantities of this tissue can be obtained from existing paraffin blocks to provide a viable and rich biospecimen source for focused gene expression assays. In addition, reliable and reproducible gene expression evaluation can be performed on these FFPE tissues using either a QPCR-based or a barcoded-oligo approach, which provides opportunities for collaborative analytics.

Published
2018

75. Position reconstruction in LUX

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Cahn, SB, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Druszkiewicz, E, Edwards, BN, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, D-M, Mock, J, Moongweluwan, M, Morad, JA, Murphy, Nehrkorn, C, Nelson, HN, Neves, F, O'Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Dark Matter detectors, Liquid detectors, Charge transport, multiplication and electroluminescence in rare gases and liquids, Detector modelling and simulations I, physics.ins-det, hep-ex, physics.comp-ph, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract

The (x, y) position reconstruction method used in the analysis of the complete exposure of the Large Underground Xenon (LUX) experiment is presented. The algorithm is based on a statistical test that makes use of an iterative method to recover the photomultiplier tube (PMT) light response directly from the calibration data. The light response functions make use of a two dimensional functional form to account for the photons reflected on the inner walls of the detector. To increase the resolution for small pulses, a photon counting technique was employed to describe the response of the PMTs. The reconstruction was assessed with calibration data including 83mKr (releasing a total energy of 41.5 keV) and 3H (andbeta;- with Q = 18.6 keV) decays, and a deuterium-deuterium (D-D) neutron beam (2.45 MeV) . Within the detector's fiducial volume, the reconstruction has achieved an (x, y) position uncertainty of andsigma; = 0.82 cm and andsigma; = 0.17 cm for events of only 200 and 4,000 detected electroluminescence photons respectively. Such signals are associated with electron recoils of energies andsim;0.25 keV and andsim;10 keV, respectively. The reconstructed position of the smallest events with a single electron emitted from the liquid surface (22 detected photons) has a horizontal (x, y) uncertainty of 2.13 cm.

Published
2018

76. Chromatographic separation of radioactive noble gases from xenon

Author

Akerib, DS, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Bramante, R, Cahn, SB, Carmona-Benitez, MC, Chan, C, Chiller, AA, Chiller, C, Coffey, T, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Dobson, JEY, Druszkiewicz, E, Edwards, BN, Faham, CH, Fiorucci, S, Gaitskell, RJ, Gehman, VM, Ghag, C, Gibson, KR, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Ihm, M, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lee, C, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, D-M, Mock, J, Moongweluwan, M, Morad, JA, Murphy, Nehrkorn, C, Nelson, HN, Neves, F, O’Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Pech, K, Phelps, P, Reichhart, L, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solovov, VN, Sorensen, P, Stephenson, S, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, W, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Yazdani, K, Young, SK, and Zhang, C

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Xenon, Krypton, Adsorption, Chromatography, Gas Separation, Dark Matter, physics.ins-det, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics, Astronomical sciences, Particle and high energy physics
Abstract

The Large Underground Xenon (LUX) experiment operates at the Sanford Underground Research Facility to detect nuclear recoils from the hypothetical Weakly Interacting Massive Particles (WIMPs) on a liquid xenon target. Liquid xenon typically contains trace amounts of the noble radioactive isotopes 85Kr and 39Ar that are not removed by the in situ gas purification system. The decays of these isotopes at concentrations typical of research-grade xenon would be a dominant background for a WIMP search experiment. To remove these impurities from the liquid xenon, a chromatographic separation system based on adsorption on activated charcoal was built. 400 kg of xenon was processed, reducing the average concentration of krypton from 130 ppb to 3.5 ppt as measured by a cold-trap assisted mass spectroscopy system. A 50 kg batch spiked to 0.001 g/g of krypton was processed twice and reduced to an upper limit of 0.2 ppt.

Published
2018

77. Kidney biopsy-based epidemiologic analysis shows growing biopsy rate among the elderly

Author

Adél Molnár, Mbuotidem Jeremiah Thomas, Attila Fintha, Magdolna Kardos, Deján Dobi, András Tislér, and Nóra Ledó

Subjects
Medicine, Science
Abstract

Abstract Systematic registration and examination of biopsy-related data in Central and Eastern Europe are scarce, while the health condition of the population is worse compared to other more developed countries. We aim to create a database and analyze the distribution and temporal variation of the renal biopsy diagnoses in Hungary, including the effect of the recent coronavirus pandemic. The diagnoses were standardized according to the recommendation of the European Renal Association. Native biopsy samples processed between January 1, 2006, and December 31, 2020, were analyzed. During the 15 years, 2140 native kidney biopsies were performed. The number of samples increased from 24.5 to 57.9 per million person-years and the median age from 37 to 51 years (p

Published
2021
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78. Ultralow energy calibration of LUX detector using Xe 127 electron capture

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Cahn, SB, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Druszkiewicz, E, Edwards, BN, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, DM, Mock, J, Moongweluwan, M, Morad, JA, Murphy, ASJ, Nehrkorn, C, Nelson, HN, Neves, F, O'Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
physics.ins-det, astro-ph.IM, hep-ex
Abstract

We report an absolute calibration of the ionization yields (Qy) and fluctuations for electronic recoil events in liquid xenon at discrete energies between 186 eV and 33.2 keV. The average electric field applied across the liquid xenon target is 180 V/cm. The data are obtained using low energy Xe127 electron capture decay events from the 95.0-day first run from LUX (WS2013) in search of weakly interacting massive particles. The sequence of gamma-ray and x-ray cascades associated with I127 deexcitations produces clearly identified two-vertex events in the LUX detector. We observe the K-(binding energy, 33.2 keV), L-(5.2 keV), M-(1.1 keV), and N-(186 eV) shell cascade events and verify that the relative ratio of observed events for each shell agrees with calculations. The N-shell cascade analysis includes single extracted electron (SE) events and represents the lowest-energy electronic recoil in situ measurements that have been explored in liquid xenon.

Published
2017

79. Kr 83 m calibration of the 2013 LUX dark matter search

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Cahn, SB, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Druszkiewicz, E, Edwards, BN, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, DM, Mock, J, Moongweluwan, M, Morad, JA, Murphy, ASJ, Nehrkorn, C, Nelson, HN, Neves, F, O'Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
physics.ins-det
Abstract

LUX was the first dark matter experiment to use a Kr83m calibration source. In this paper, we describe the source preparation and injection. We also present several Kr83m calibration applications in the context of the 2013 LUX exposure, including the measurement of temporal and spatial variation in scintillation and charge signal amplitudes, and several methods to understand the electric field within the time projection chamber.

Published
2017

80. Kr83m calibration of the 2013 LUX dark matter search

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Cahn, SB, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Druszkiewicz, E, Edwards, BN, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, D-M, Mock, J, Moongweluwan, M, Morad, JA, St. J. Murphy, A, Nehrkorn, C, Nelson, HN, Neves, F, O’Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, physics.ins-det
Abstract

LUX was the first dark matter experiment to use a Kr83m calibration source. In this paper, we describe the source preparation and injection. We also present several Kr83m calibration applications in the context of the 2013 LUX exposure, including the measurement of temporal and spatial variation in scintillation and charge signal amplitudes, and several methods to understand the electric field within the time projection chamber.

Published
2017

81. Ultralow energy calibration of LUX detector using Xe127 electron capture

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Cahn, SB, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Druszkiewicz, E, Edwards, BN, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, D-M, Mock, J, Moongweluwan, M, Morad, JA, St. J. Murphy, A, Nehrkorn, C, Nelson, HN, Neves, F, O’Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Affordable and Clean Energy, physics.ins-det, astro-ph.IM, hep-ex
Abstract

We report an absolute calibration of the ionization yields (Qy) and fluctuations for electronic recoil events in liquid xenon at discrete energies between 186 eV and 33.2 keV. The average electric field applied across the liquid xenon target is 180 V/cm. The data are obtained using low energy Xe127 electron capture decay events from the 95.0-day first run from LUX (WS2013) in search of weakly interacting massive particles. The sequence of gamma-ray and x-ray cascades associated with I127 deexcitations produces clearly identified two-vertex events in the LUX detector. We observe the K-(binding energy, 33.2 keV), L-(5.2 keV), M-(1.1 keV), and N-(186 eV) shell cascade events and verify that the relative ratio of observed events for each shell agrees with calculations. The N-shell cascade analysis includes single extracted electron (SE) events and represents the lowest-energy electronic recoil in situ measurements that have been explored in liquid xenon.

Published
2017

82. Tezacaftor is a direct inhibitor of sphingolipid delta-4 desaturase enzyme (DEGS)

Author

Ciobanu, Dinu Zinovie, primary, Liessi, Nara, additional, Tomati, Valeria, additional, Capurro, Valeria, additional, Bertozzi, Sine Mandrup, additional, Summa, Maria, additional, Bertorelli, Rosalia, additional, Loberto, Nicoletta, additional, Dobi, Dorina, additional, Aureli, Massimo, additional, Nobbio, Lucilla, additional, Bandiera, Tiziano, additional, Pedemonte, Nicoletta, additional, Bassi, Rosaria, additional, and Armirotti, Andrea, additional

Published
2024
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83. Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency

Author

Szallasi, Zoltan, primary, Diossy, Miklos, additional, Tisza, Viktoria, additional, Li, Hua, additional, Sahgal, Pranshu, additional, Zhou, Jia, additional, Sztupinszki, Zsofia, additional, Young, Denise, additional, Nuosome, Darryl, additional, Kuo, Claire, additional, Jiang, Jiji, additional, Chen, Yongmei, additional, Ebner, Reinhard, additional, Sesterhenn, Isabell, additional, Moncur, Joel, additional, Chesnut, Gregory, additional, Petrovics, Gyorgy, additional, T.Klus, Gregory, additional, Valcz, Gábor, additional, Nuzzo, Pier, additional, Ribli, Dezso, additional, Börcsök, Judit, additional, Prósz, Aurél, additional, Krzystanek, Marcin, additional, Ried, Thomas, additional, Szüts, Dávid, additional, Rizwan, Kinza, additional, Kaochar, Salma, additional, Pathania, Shailja, additional, D'Andrea, Alan, additional, Csabai, István, additional, Srivast, Shib, additional, Freedman, Matthew, additional, Dobi, Albert, additional, and Spisak, Sandor, additional

Published
2024
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90. Signal yields, energy resolution, and recombination fluctuations in liquid xenon

Author

Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Bramante, R., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Ihm, M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. -M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Phelps, P., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This work presents an analysis of monoenergetic electronic recoil peaks in the dark-matter-search and calibration data from the first underground science run of the Large Underground Xenon (LUX) detector. Liquid xenon charge and light yields for electronic recoil energies between 5.2 and 661.7 keV are measured, as well as the energy resolution for the LUX detector at those same energies. Additionally, there is an interpretation of existing measurements and descriptions of electron-ion recombination fluctuations in liquid xenon as limiting cases of a more general liquid xenon re- combination fluctuation model. Measurements of the standard deviation of these fluctuations at monoenergetic electronic recoil peaks exhibit a linear dependence on the number of ions for energy deposits up to 661.7 keV, consistent with previous LUX measurements between 2-16 keV with $^3$H. We highlight similarities in liquid xenon recombination for electronic and nuclear recoils with a comparison of recombination fluctuations measured with low-energy calibration data., Comment: 11 pages, 12 figures, 3 tables

Published
2016
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91. Results from a search for dark matter in the complete LUX exposure

Author

Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Bramante, R., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Ihm, M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O`Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Phelps, P., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We report constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35e4 kg-day exposure of the Large Underground Xenon (LUX) experiment. A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead, South Dakota (USA). With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results, this search yields no evidence of WIMP nuclear recoils. At a WIMP mass of 50 GeV/c^2, WIMP-nucleon spin-independent cross sections above 2.2e-46 cm^2 are excluded at the 90% confidence level. When combined with the previously reported LUX exposure, this exclusion strengthens to 1.1e-46 cm^2 at 50 GeV/c^2., Comment: This version includes a combined analysis with previously published LUX results, and matches the version published in PRL

Published
2016
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92. Low-energy (0.7-74 keV) nuclear recoil calibration of the LUX dark matter experiment using D-D neutron scattering kinematics

Author

LUX Collaboration, Akerib, D. S., Alsum, S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Bradley, A., Bramante, R., Brás, P., Byram, D., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chapman, J. J., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Ihm, M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Malling, D. C., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pangilinan, M., Pease, E. K., Phelps, P., Reichhart, L., Rhyne, C. A., Shaw, S., Shutt, T. A., Silva, C., Solmaz, M., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W. C., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Xu, J., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The Large Underground Xenon (LUX) experiment is a dual-phase liquid xenon time projection chamber (TPC) operating at the Sanford Underground Research Facility in Lead, South Dakota. A calibration of nuclear recoils in liquid xenon was performed $\textit{in situ}$ in the LUX detector using a collimated beam of mono-energetic 2.45 MeV neutrons produced by a deuterium-deuterium (D-D) fusion source. The nuclear recoil energy from the first neutron scatter in the TPC was reconstructed using the measured scattering angle defined by double-scatter neutron events within the active xenon volume. We measured the absolute charge ($Q_{y}$) and light ($L_{y}$) yields at an average electric field of 180 V/cm for nuclear recoil energies spanning 0.7 to 74 keV and 1.1 to 74 keV, respectively. This calibration of the nuclear recoil signal yields will permit the further refinement of liquid xenon nuclear recoil signal models and, importantly for dark matter searches, clearly demonstrates measured ionization and scintillation signals in this medium at recoil energies down to $\mathcal{O}$(1 keV)., Comment: 24 pages, 15 figures, 6 tables

Published
2016

93. Chromatographic separation of radioactive noble gases from xenon

Author

LUX Collaboration, Akerib, D. S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Bramante, R., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chiller, A. A., Chiller, C., Coffey, T., Currie, A., Cutter, J. E., Davison, T. J. R., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Ihm, M., Jacobsen, R. G., Ji, W., Kamdin, K., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. -M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Palladino, K. J., Pease, E. K., Pech, K., Phelps, P., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors
Abstract

The Large Underground Xenon (LUX) experiment operates at the Sanford Underground Research Facility to detect nuclear recoils from the hypothetical Weakly Interacting Massive Particles (WIMPs) on a liquid xenon target. Liquid xenon typically contains trace amounts of the noble radioactive isotopes $^{85}$Kr and $^{39}$Ar that are not removed by the in situ gas purification system. The decays of these isotopes at concentrations typical of research-grade xenon would be a dominant background for a WIMP search exmperiment. To remove these impurities from the liquid xenon, a chromatographic separation system based on adsorption on activated charcoal was built. 400 kg of xenon was processed, reducing the average concentration of krypton from 130 ppb to 3.5 ppt as measured by a cold-trap assisted mass spectroscopy system. A 50 kg batch spiked to 0.001 g/g of krypton was processed twice and reduced to an upper limit of 0.2 ppt., Comment: Accepted in Astropart. Phys

Published
2016
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94. Results on the Spin-Dependent Scattering of Weakly Interacting Massive Particles on Nucleons from the Run 3 Data of the LUX Experiment

Author

LUX Collaboration, Akerib, D. S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Bradley, A., Bramante, R., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chapman, J. J., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Ihm, M., Jacobsen, R. G., Ji, W., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Malling, D. C., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O'Sullivan, K., Oliver-Mallory, K. C., Ott, R. A., Palladino, K. J., Pangilinan, M., Pease, E. K., Phelps, P., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We present the first experimental constraints on the spin-dependent WIMP-nucleon elastic cross sections from LUX data acquired in 2013. LUX is a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility (Lead, South Dakota), which is designed to observe the recoil signature of galactic WIMPs scattering from xenon nuclei. A profile likelihood ratio analysis of $1.4~\times~10^{4}~\text{kg}\cdot~\text{days}$ of fiducial exposure allows 90% CL upper limits to be set on the WIMP-neutron (WIMP-proton) cross section of $\sigma_n~=~9.4~\times~10^{-41}~\text{cm}^2$ ($\sigma_p~=~2.9~\times~10^{-39}~\text{cm}^2$) at 33 GeV/c$^2$. The spin-dependent WIMP-neutron limit is the most sensitive constraint to date., Comment: 6 pages, 2 figures

Published
2016
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95. Cardiotoxicity is mitigated after a supervised exercise program in HER2-positive breast cancer undergoing adjuvant trastuzumab

Author

Quentin Jacquinot, Nathalie Meneveau, Antoine Falcoz, Malika Bouhaddi, Pauline Roux, Bruno Degano, Marion Chatot, Elsa Curtit, Laura Mansi, Marie-Justine Paillard, Fernando Bazan, Loïc Chaigneau, Erion Dobi, Guillaume Meynard, Dewi Vernerey, Xavier Pivot, and Fabienne Mougin

Subjects
breast cancer, HER2 overexpression, cardiotoxicity, supervised exercise program, prevention, supportive care, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundTrastuzumab is used, alone or in conjunction with standard chemotherapy, to treat HER2-positive breast cancer (BC). Although it improves cancer outcomes, trastuzumab. can lead to cardiotoxicity. Physical exercise is a safe and effective supportive therapy in the management of side effects, but the cardioprotective effects of exercise are still unclear.ObjectivesThe primary aim of this study was to test whether trastuzumab-induced cardiotoxicity [left ventricular ejection fraction (LVEF) under 50%, or an absolute drop in LVEF of 10%] was reduced after a supervised exercise program of 3 months in patients with HER2-positive breast cancer. Secondary endpoints were to evaluate (i) cardiotoxicity rates using other criteria, (ii) cardiac parameters, (iii) cardiorespiratory fitness and (iv) whether a change in LVEF influences the cardiorespiratory fitness.Methods89 women were randomized to receive adjuvant trastuzumab in combination with a training program (training group: TG; n = 46) or trastuzumab alone (control group: CG; n = 43). The primary and secondary endpoints were evaluated at the end of the supervised exercise program of 3 months (T3).ResultsAfter exercise program, 90.5 % of TG patients and 81.8% of CG patients did not exhibit cardiotoxicity. Furthermore, whatever the used criterion, percentage of patients without cardiotoxicity were greater in TG (97.6 and 100% respectively) than in CG (90.9 and 93.9% respectively). LVEF and GLS values remained stable in both groups without any difference between the groups. In contrast, at T3, peak VO2 (+2.6 mL.min−1.kg−1; 95%CI, 1.8 to 3.4) and maximal power (+21.3 W; 95%CI, 17.3 to 25.3) increased significantly in TG, whereas they were unchanged in CG (peak VO2: +0.2 mL.min−1.kg−1; 95%CI, −0.5 to 0.9 and maximal power: +0.7 W, 95%CI, −3.6 to 5.1) compared to values measured at T0. No correlation between LVEF changes and peak VO2 or maximal power was observed.ConclusionA 12-week supervised exercise regimen was safe and improved the cardiopulmonary fitness in particular peak VO2, in HER2-positive BC patients treated with adjuvant trastuzumab therapy. The study is under powered to come to any conclusion regarding the effect on cardiotoxicity.Clinical trial registrationwww.ClinicalTrials.gov, identifier: NCT02433067.

Published
2022
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96. Improved Limits on Scattering of Weakly Interacting Massive Particles from Reanalysis of 2013 LUX data

Author

LUX Collaboration, Akerib, D. S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Bradley, A., Bramante, R., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chapman, J. J., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Ihm, M., Jacobsen, R. G., Ji, W., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Malling, D. C., Manalaysay, A., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O`Sullivan, K., Oliver-Mallory, K. C., Ott, R. A., Palladino, K. J., Pangilinan, M., Pease, E. K., Phelps, P., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Yazdani, K., Young, S. K., and Zhang, C.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

We present constraints on weakly interacting massive particles (WIMP)-nucleus scattering from the 2013 data of the Large Underground Xenon dark matter experiment, including $1.4\times10^{4}\;\mathrm{kg\; day}$ of search exposure. This new analysis incorporates several advances: single-photon calibration at the scintillation wavelength, improved event-reconstruction algorithms, a revised background model including events originating on the detector walls in an enlarged fiducial volume, and new calibrations from decays of an injected tritium $\beta$ source and from kinematically constrained nuclear recoils down to 1.1 keV. Sensitivity, especially to low-mass WIMPs, is enhanced compared to our previous results which modeled the signal only above a 3 keV minimum energy. Under standard dark matter halo assumptions and in the mass range above 4 $\mathrm{GeV}\,c^{-2}$, these new results give the most stringent direct limits on the spin-independent WIMP-nucleon cross section. The 90% C.L. upper limit has a minimum of 0.6 zb at 33 $\mathrm{GeV}\,c^{-2}$ WIMP mass., Comment: Accepted by Phys. Rev. Lett

Published
2015
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97. Model-based Hazard and Impact Analysis

Author

Dobi, Sonila, Gleirscher, Mario, Spichkova, Maria, and Struss, Peter

Subjects
Computer Science - Software Engineering
Abstract

Hazard and impact analysis is an indispensable task during the specification and development of safety-critical technical systems, and particularly of their software-intensive control parts. There is a lack of methods supporting an effective (reusable, automated) and integrated (cross-disciplinary) way to carry out such analyses. This report was motivated by an industrial project whose goal was to survey and propose methods and models for documentation and analysis of a system and its environment to support hazard and impact analysis as an important task of safety engineering and system development. We present and investigate three perspectives of how to properly encode safety-relevant domain knowledge for better reuse and automation, identify and assess all relevant hazards, as well as pre-process this information and make it easily accessible for reuse in other safety and systems engineering activities and, moreover, in similar engineering projects.

Published
2015

98. Tritium calibration of the LUX dark matter experiment

Author

LUX Collaboration, Akerib, D. S., Araújo, H. M., Bai, X., Bailey, A. J., Balajthy, J., Beltrame, P., Bernard, E. P., Bernstein, A., Biesiadzinski, T. P., Boulton, E. M., Bradley, A., Bramante, R., Cahn, S. B., Carmona-Benitez, M. C., Chan, C., Chapman, J. J., Chiller, A. A., Chiller, C., Currie, A., Cutter, J. E., Davison, T. J. R., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Edwards, B. N., Faham, C. H., Fiorucci, S., Gaitskell, R. J., Gehman, V. M., Ghag, C., Gibson, K. R., Gilchriese, M. G. D., Hall, C. R., Hanhardt, M., Haselschwardt, S. J., Hertel, S. A., Hogan, D. P., Horn, M., Huang, D. Q., Ignarra, C. M., Ihm, M., Jacobsen, R. G., Ji, W., Kazkaz, K., Khaitan, D., Knoche, R., Larsen, N. A., Lee, C., Lenardo, B. G., Lesko, K. T., Lindote, A., Lopes, M. I., Malling, D. C., Manalaysay, A. G., Mannino, R. L., Marzioni, M. F., McKinsey, D. N., Mei, D. M., Mock, J., Moongweluwan, M., Morad, J. A., Murphy, A. St. J., Nehrkorn, C., Nelson, H. N., Neves, F., O`Sullivan, K., Oliver-Mallory, K. C., Ott, R. A., Palladino, K. J., Pangilinan, M., Pease, E. K., Phelps, P., Reichhart, L., Rhyne, C., Shaw, S., Shutt, T. A., Silva, C., Solovov, V. N., Sorensen, P., Stephenson, S., Sumner, T. J., Szydagis, M., Taylor, D. J., Taylor, W., Tennyson, B. P., Terman, P. A., Tiedt, D. R., To, W. H., Tripathi, M., Tvrznikova, L., Uvarov, S., Verbus, J. R., Webb, R. C., White, J. T., Whitis, T. J., Witherell, M. S., Wolfs, F. L. H., Young, S. K., and Zhang, C.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

We present measurements of the electron-recoil (ER) response of the LUX dark matter detector based upon 170,000 highly pure and spatially-uniform tritium decays. We reconstruct the tritium energy spectrum using the combined energy model and find good agreement with expectations. We report the average charge and light yields of ER events in liquid xenon at 180 V/cm and 105 V/cm and compare the results to the NEST model. We also measure the mean charge recombination fraction and its fluctuations, and we investigate the location and width of the LUX ER band. These results provide input to a re-analysis of the LUX Run3 WIMP search.

Published
2015
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99. Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia

Author

Michael A. Kiebish, Poornima Tekumalla, Shobha Ravipaty, Albert Dobi, Shiv Srivastava, Wenfang Wu, Saurabh Patil, Tracey Friss, Allison Klotz, Alagarsamy Srinivasan, Jennifer Cullen, Inger L. Rosner, Amina Ali, Sandra Laszlo, Michele Petrovic, Neil Fleshner, Jeonifer Garren, Greg Miller, Nischal Mahaveer Chand, Leonardo O. Rodrigues, Elder Granger, Mark D. Kellogg, Shen Luan, Eleftherios Diamandis, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Chas Bountra, Stephen J. Freedland, David G. McLeod, and Niven R. Narain

Subjects
Medicine, Science
Abstract

Abstract Prostate-specific antigen (PSA) screening for prostate cancer (PCa) is limited by the lack of specificity but is further complicated in the benign prostatic hyperplasia (BPH) population which also exhibit elevated PSA, representing a clear unmet need to distinguish BPH from PCa. Herein, we evaluated the utility of FLNA IP-MRM, age, and prostate volume to stratify men with BPH from those with PCa. Diagnostic performance of the biomarker panel was better than PSA alone in discriminating patients with negative biopsy from those with PCa, as well as those who have had multiple prior biopsies (AUC 0.75 and 0.87 compared to AUC of PSA alone 0.55 and 0.57 for patients who have had single compared to multiple negative biopsies, respectively). Of interest, in patients with PCa, the panel demonstrated improved performance than PSA alone in those with Gleason scores of 5–7 (AUC 0.76 vs. 0.56) and Gleason scores of 8–10 (AUC 0.74 vs. 0.47). With Gleason scores (8–10), the negative predictive value of the panel is 0.97, indicating potential to limit false negatives in aggressive cancers. Together, these data demonstrate the ability of the biomarker panel to perform better than PSA alone in men with BPH, thus preventing unnecessary biopsies.

Published
2021
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100. 3D modeling of electric fields in the LUX detector

Author

Akerib, DS, Alsum, S, Araújo, HM, Bai, X, Bailey, AJ, Balajthy, J, Beltrame, P, Bernard, EP, Bernstein, A, Biesiadzinski, TP, Boulton, EM, Brás, P, Byram, D, Cahn, SB, Carmona-Benitez, MC, Chan, C, Currie, A, Cutter, JE, Davison, TJR, Dobi, A, Druszkiewicz, E, Edwards, BN, Fallon, SR, Fan, A, Fiorucci, S, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hanhardt, M, Haselschwardt, SJ, Hertel, SA, Hogan, DP, Horn, M, Huang, DQ, Ignarra, CM, Jacobsen, RG, Ji, W, Kamdin, K, Kazkaz, K, Khaitan, D, Knoche, R, Larsen, NA, Lenardo, BG, Lesko, KT, Lindote, A, Lopes, MI, Manalaysay, A, Mannino, RL, Marzioni, MF, McKinsey, DN, Mei, DM, Mock, J, Moongweluwan, M, Morad, JA, Murphy, ASJ, Nehrkorn, C, Nelson, HN, Neves, F, O'Sullivan, K, Oliver-Mallory, KC, Palladino, KJ, Pease, EK, Rhyne, C, Shaw, S, Shutt, TA, Silva, C, Solmaz, M, Solovov, VN, Sorensen, P, Sumner, TJ, Szydagis, M, Taylor, DJ, Taylor, WC, Tennyson, BP, Terman, PA, Tiedt, DR, To, WH, Tripathi, M, Tvrznikova, L, Uvarov, S, Velan, V, Verbus, JR, Webb, RC, White, JT, Whitis, TJ, Witherell, MS, Wolfs, FLH, Xu, J, Yazdani, K, Young, SK, and Zhang, C

Subjects
Analysis and statistical methods, Detector modelling and simulations II, Noble liquid detectors, Dark Matter detectors, physics.ins-det, hep-ex, physics.comp-ph, Nuclear & Particles Physics, Physical Sciences, Engineering
Abstract

This work details the development of a three-dimensional (3D) electric field model for the LUX detector. The detector took data to search for weakly interacting massive particles (WIMPs) during two periods. After the first period completed, a time-varying non-uniform negative charge developed in the polytetrafluoroethylene (PTFE) panels that define the radial boundary of the detector's active volume. This caused electric field variations in the detector in time, depth and azimuth, generating an electrostatic radially-inward force on electrons on their way upward to the liquid surface. To map this behavior, 3D electric field maps of the detector's active volume were generated on a monthly basis. This was done by fitting a model built in COMSOL Multiphysics to the uniformly distributed calibration data that were collected on a regular basis. The modeled average PTFE charge density increased over the course of the exposure from -3.6 to -5.5 μC/m2. From our studies, we deduce that the electric field magnitude varied locally while the mean value of the field of ∼200 V/cm remained constant throughout the exposure. As a result of this work the varying electric fields and their impact on event reconstruction and discrimination were successfully modeled.

Published
2017

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