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59 results on '"Dittmayer, Carsten"'

51. Caveolin 1 Promotes Renal Water and Salt Reabsorption

Author

Willière, Yan, primary, Borschewski, Aljona, additional, Patzak, Andreas, additional, Nikitina, Tatiana, additional, Dittmayer, Carsten, additional, Daigeler, Anna L., additional, Schuelke, Markus, additional, Bachmann, Sebastian, additional, and Mutig, Kerim, additional

Published
2018
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55. Morphological Characteristics of Idiopathic Inflammatory Myopathies in Juvenile Patients.

Author

Schänzer, Anne, Rager, Leonie, Dahlhaus, Iris, Dittmayer, Carsten, Preusse, Corinna, Della Marina, Adela, Goebel, Hans-Hilmar, Hahn, Andreas, and Stenzel, Werner

Subjects
MYOSITIS, MUSCLE diseases, MUSCLE weakness, TRANSMISSION electron microscopy, ALKALINE phosphatase, DERMATOMYOSITIS
Abstract

Background: In juvenile idiopathic inflammatory myopathies (IIMs), morphological characteristic features of distinct subgroups are not well defined. New treatment strategies require a precise diagnosis of the subgroups in IIM, and, therefore, knowledge about the pathomorphology of juvenile IIMs is warranted. Methods: Muscle biopsies from 15 patients (median age 8 (range 3–17) years, 73% female) with IIM and seven controls were analyzed by standard methods, immunohistochemistry, and transmission electron microscopy (TEM). Detailed clinical and laboratory data were accessed retrospectively. Results: Proximal muscle weakness and skin symptoms were the main clinical symptoms. Dermatomyositis (DM) was diagnosed in 9/15, antisynthetase syndrome (ASyS) in 4/15, and overlap myositis (OM) in 2/15. Analysis of skeletal muscle tissues showed inflammatory cells and diffuse upregulation of MHC class I in all subtypes. Morphological key findings were COX-deficient fibers as a striking pathology in DM and perimysial alkaline phosphatase positivity in anti-Jo-1-ASyS. Vascular staining of the type 1 IFN-surrogate marker, MxA, correlated with endothelial tubuloreticular inclusions in both groups. None of these specific morphological findings were present in anti-PL7-ASyS or OM patients. Conclusions: Morphological characteristics discriminate IIM subtypes in juvenile patients, emphasizing differences in aetiopathogenesis and supporting the notion of individual and targeted therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2022
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57. Microglia regulate central nervous system myelin growth and integrity

Author

Niamh B. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. Holloway, Irene Molina-Gonzalez, Katharine E. Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W. McColl, Marco Prinz, Tara L. Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J. A. Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E. Miron, Molina-Gonzalez, Irene/0000-0001-5966-0351, Miron, Veronique/0000-0003-1738-0647, McNamara, Niamh/0000-0002-9769-367X, Munro, David/0000-0002-3521-2121, McNamara, Niamh B. B., Munro, David A. D., Bestard-Cuche, Nadine, Uyeda, Akiko, BOGIE, Jeroen, Hoffmann, Alana, Holloway, Rebecca K. K., Molina-Gonzalez, Irene, Askew, Katharine E. E., Mitchell, Stephen, Mungall, William, Dodds, Michael, Dittmayer, Carsten, Moss, Jonathan, Rose, Jamie, Szymkowiak, Stefan, Amann, Lukas, McColl, Barry W. W., Prinz, Marco, Spires-Jones, Tara L. L., Stenzel, Werner, Horsburgh, Karen, HENDRIKS, Jerome, Pridans, Clare, Muramatsu, Rieko, Williams, Anna, Priller, Josef, and Miron, Veronique E. E.

Subjects
Central Nervous System, Adult, metabolism [Myelin Sheath], metabolism [Microglia], metabolism [Neurodegenerative Diseases], metabolism [Axons], cytology [Central Nervous System], metabolism [Oligodendroglia], Mice, Cognition, pathology [Aging], pathology [Myelin Sheath], Humans, Animals, cytology [Microglia], metabolism [Aging], Myelin Sheath, Multidisciplinary, pathology [Neurodegenerative Diseases], pathology [Microglia], Neurodegenerative Diseases, Lipid Metabolism, Axons, metabolism [Receptor, Transforming Growth Factor-beta Type I], Oligodendroglia, metabolism [Transforming Growth Factor beta1], pathology [Oligodendroglia], metabolism [Central Nervous System], Microglia, ddc:500, pathology [Central Nervous System]
Abstract

Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health1, it is unknown which macrophage populations are involved and which aspects they influence. Here we show that resident microglia are crucial for the maintenance of myelin health in adulthood in both mice and humans. We demonstrate that microglia are dispensable for developmental myelin ensheathment. However, they are required for subsequent regulation of myelin growth and associated cognitive function, and for preservation of myelin integrity by preventing its degeneration. We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte state with altered lipid metabolism. Moreover, this mechanism is regulated through disruption of the TGFβ1–TGFβR1 axis. Our findings highlight microglia as promising therapeutic targets for conditions in which myelin growth and integrity are dysregulated, such as in ageing and neurodegenerative disease2,3.

Published
2023

58. DNA methylation-based classification of sinonasal tumors

Author

Philipp Jurmeister, Stefanie Glöß, Renée Roller, Maximilian Leitheiser, Simone Schmid, Liliana H. Mochmann, Emma Payá Capilla, Rebecca Fritz, Carsten Dittmayer, Corinna Friedrich, Anne Thieme, Philipp Keyl, Armin Jarosch, Simon Schallenberg, Hendrik Bläker, Inga Hoffmann, Claudia Vollbrecht, Annika Lehmann, Michael Hummel, Daniel Heim, Mohamed Haji, Patrick Harter, Benjamin Englert, Stephan Frank, Jürgen Hench, Werner Paulus, Martin Hasselblatt, Wolfgang Hartmann, Hildegard Dohmen, Ursula Keber, Paul Jank, Carsten Denkert, Christine Stadelmann, Felix Bremmer, Annika Richter, Annika Wefers, Julika Ribbat-Idel, Sven Perner, Christian Idel, Lorenzo Chiariotti, Rosa Della Monica, Alfredo Marinelli, Ulrich Schüller, Michael Bockmayr, Jacklyn Liu, Valerie J. Lund, Martin Forster, Matt Lechner, Sara L. Lorenzo-Guerra, Mario Hermsen, Pascal D. Johann, Abbas Agaimy, Philipp Seegerer, Arend Koch, Frank Heppner, Stefan M. Pfister, David T. W. Jones, Martin Sill, Andreas von Deimling, Matija Snuderl, Klaus-Robert Müller, Erna Forgó, Brooke E. Howitt, Philipp Mertins, Frederick Klauschen, David Capper, Jurmeister, Philipp, Glöß, Stefanie, Roller, Renée, Leitheiser, Maximilian, Schmid, Simone, Mochmann, Liliana H, Payá Capilla, Emma, Fritz, Rebecca, Dittmayer, Carsten, Friedrich, Corinna, Thieme, Anne, Keyl, Philipp, Jarosch, Armin, Schallenberg, Simon, Bläker, Hendrik, Hoffmann, Inga, Vollbrecht, Claudia, Lehmann, Annika, Hummel, Michael, Heim, Daniel, Haji, Mohamed, Harter, Patrick, Englert, Benjamin, Frank, Stephan, Hench, Jürgen, Paulus, Werner, Hasselblatt, Martin, Hartmann, Wolfgang, Dohmen, Hildegard, Keber, Ursula, Jank, Paul, Denkert, Carsten, Stadelmann, Christine, Bremmer, Felix, Richter, Annika, Wefers, Annika, Ribbat-Idel, Julika, Perner, Sven, Idel, Christian, Chiariotti, Lorenzo, Della Monica, Rosa, Marinelli, Alfredo, Schüller, Ulrich, Bockmayr, Michael, Liu, Jacklyn, Lund, Valerie J, Forster, Martin, Lechner, Matt, Lorenzo-Guerra, Sara L, Hermsen, Mario, Johann, Pascal D, Agaimy, Abba, Seegerer, Philipp, Koch, Arend, Heppner, Frank, Pfister, Stefan M, Jones, David T W, Sill, Martin, von Deimling, Andrea, Snuderl, Matija, Müller, Klaus-Robert, Forgó, Erna, Howitt, Brooke E, Mertins, Philipp, Klauschen, Frederick, and Capper, David

Subjects
Proteomics, Multidisciplinary, Carcinoma, DNA Helicases, Reproducibility of Results, Nuclear Proteins, General Physics and Astronomy, General Chemistry, DNA Methylation, General Biochemistry, Genetics and Molecular Biology, Humans, ddc:610, Technology Platforms, Transcription Factors
Abstract

The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SNUCs). In this study, we apply a machine learning algorithm based on DNA methylation patterns to classify sinonasal tumors with clinical-grade reliability. We further show that sinonasal tumors with SNUC morphology are not as undifferentiated as their current terminology suggests but rather reassigned to four distinct molecular classes defined by epigenetic, mutational and proteomic profiles. This includes two classes with neuroendocrine differentiation, characterized by IDH2 or SMARCA4/ARID1A mutations with an overall favorable clinical course, one class composed of highly aggressive SMARCB1-deficient carcinomas and another class with tumors that represent potentially previously misclassified adenoid cystic carcinomas. Our findings can aid in improving the diagnostic classification of sinonasal tumors and could help to change the current perception of SNUCs.

Published
2022

59. The ultrastructural heterogeneity of lung surfactant revealed by serial section electron tomography: insights into the 3-D architecture of human tubular myelin.

Author

Lettau M, Timm S, Dittmayer C, Lopez-Rodriguez E, and Ochs M

Subjects
Animals, Humans, Lung ultrastructure, Mice, Myelin Sheath, Surface-Active Agents, Electron Microscope Tomography, Pulmonary Surfactants
Abstract

Weibel's hypothetical three-dimensional (3-D) model in 1966 provided first ultrastructural details into tubular myelin (TM), a unique, complex surfactant subtype found in the hypophase of the alveolar lining layer. Although initial descriptions by electron microscopy (EM) were already published in the 1950s, a uniform morphological differentiation from other intra-alveolar surfactant subtypes is still missing and potential structure-function relationships remain enigmatic. Technical developments in volume EM methods now allow a more detailed reinvestigation, to address unanswered ultrastructural questions, we analyzed ultrathin sections of humanized SP-A1/SP-A2 coexpressing mouse and human lung samples by conventional transmission EM. We combined these two-dimensional (2-D) information with 3-D analysis of single- and dual-axis electron tomography of serial sections for high z -resolution (in a range of a few nanometers) and extended volumes of up to 1 µm total z -information, this study reveals that TM constitutes a heterogeneous surfactant organization mainly comprised of distorted parallel membrane planes with local intersections, which are distributed all over the TM substructure. These intersecting membrane planes form, among other various polygons, the well-known 2-D "lattice", respectively 3-D quadratic tubules, which in many analyzed spots of human alveoli appear to be less abundant than also observed nonconcentric 3-D lamellae, the additional application of serial section electron tomography to conventional transmission EM demonstrates a high heterogeneity of TM membrane networks, which indicates dynamic transformations between its substructures. Our method provides an ideal basis for further in and ex vivo structural analyses of surfactant under various conditions at nanometer scale.

Published
2022
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