223 results on '"Disa JJ"'
Search Results
52. Discussion: Silicone Implant Illness: Science versus Myth?
- Author
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Disa JJ
- Subjects
- Breast Implants, Silicone Gels
- Published
- 2019
- Full Text
- View/download PDF
53. Discussion: Risk-to-Benefit Relationship of Contralateral Prophylactic Mastectomy: The Argument for Bilateral Mastectomies with Immediate Reconstruction.
- Author
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Disa JJ and Matros E
- Subjects
- Humans, Mastectomy, Risk Assessment, Breast Neoplasms surgery, Carcinoma, Intraductal, Noninfiltrating surgery, Mammaplasty
- Published
- 2019
- Full Text
- View/download PDF
54. Outcomes Utilizing Inspira Implants in Primary Aesthetic and Reconstructive Surgery.
- Author
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Warren Peled A and Disa JJ
- Subjects
- Breast anatomy & histology, Breast surgery, Breast Implantation adverse effects, Breast Neoplasms surgery, Decision Making, Elasticity, Esthetics, Female, Humans, Implant Capsular Contracture etiology, Mastectomy adverse effects, Silicone Gels adverse effects, Treatment Outcome, Breast Implantation instrumentation, Breast Implants adverse effects, Implant Capsular Contracture prevention & control, Prosthesis Design
- Abstract
The evolution of silicone implants has included advances in both gel and shell technology to improve the clinical outcomes of the implants. The newest generation of implants includes implants with thick, strong shells and highly cohesive gel fill. These advancements allow for better maintenance of implant form and shape over time and improved implant safety. The Natrelle Inspira product line offers 3 different levels of gel cohesivity in a range of profiles to provide a wide variety of options for use in both breast augmentation and postmastectomy breast reconstruction. This article will review the use of Inspira implants in primary aesthetic and reconstructive breast surgery.
- Published
- 2019
- Full Text
- View/download PDF
55. Commentary on: Trans-Vertical Mastectomy With Immediate Implant-Based Reconstruction: A Retrospective, Observational Study.
- Author
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Matros E and Disa JJ
- Subjects
- Humans, Mastectomy, Retrospective Studies, Breast Implantation, Breast Implants, Breast Neoplasms surgery, Mammaplasty
- Published
- 2019
- Full Text
- View/download PDF
56. A Virtual Surgical Planning Algorithm for Delayed Maxillomandibular Reconstruction.
- Author
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Stranix JT, Stern CS, Rensberger M, Ganly I, Boyle JO, Allen RJ Jr, Disa JJ, Mehrara BJ, Garfein ES, and Matros E
- Subjects
- Adult, Aged, Algorithms, Anatomic Landmarks, Computer Simulation, Female, Free Tissue Flaps, Humans, Male, Middle Aged, Patient Care Planning, Time-to-Treatment, Treatment Outcome, Virtual Reality, Mandibular Reconstruction methods, Osteoradionecrosis surgery
- Abstract
Background: The absence of a tumor specimen from which to obtain measurements at the time of delayed maxillomandibular reconstruction introduces degrees of uncertainty, creating the need for substantial intraoperative guesswork by the surgeon. Using the virtual surgical planning environment, the size and shape of missing bony elements is determined, effectively "recreating the defect" in advance of the surgery. Three virtual surgical planning techniques assist the reconstructive surgeon: patient-specific modeling, mirroring the normal contralateral side, and scaled normative data. To facilitate delayed reconstruction a hierarchical algorithm using virtual surgical planning techniques was developed., Methods: Delayed maxillomandibular virtual surgical planning reconstructions were identified from 2009 to 2016. Demographics, modeling techniques, and surgical characteristics were analyzed., Results: Sixteen reconstructions were performed for osteoradionecrosis with displacement (50.0 percent) or oncologic defects (37.5 percent). Most patients had prior surgery (81.3 percent) and preoperative radiation therapy (81.3 percent); four had failed prior reconstructions. The following delayed virtual surgical planning techniques were used: patient-specific modeling based on previous imaging (43.8 percent), mirroring normal contralateral anatomy (37.5 percent), and scaled normative data (18.8 percent). Normative and mirrored reconstructions were designed to restore normal anatomy; however, most patient-specific virtual surgical planning designs (71.4 percent) required nonanatomical reconstructions to accommodate soft-tissue limitations and to avoid the need for a second flap. One partial flap loss required a second free flap, and one total flap failure occurred. Hardware exposure was the most common minor complication, followed by infection, dehiscence, and sinus tract formation., Conclusions: Virtual surgical planning has inherent advantages in delayed reconstruction when compared to traditional flap shaping techniques. An algorithmic approach based on available imaging and remaining native anatomy enables accurate reconstructive planning followed by flap transfer without the need for intraoperative guesswork., Clinical Question/level of Evidence: Therapeutic, IV.
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- 2019
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57. Autologous Breast Reconstruction after Failed Implant-Based Reconstruction: Evaluation of Surgical and Patient-Reported Outcomes and Quality of Life.
- Author
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Coriddi M, Shenaq D, Kenworthy E, Mbabuike J, Nelson J, Pusic A, Mehrara B, and Disa JJ
- Subjects
- Adult, Breast Implantation methods, Breast Implants adverse effects, Breast Neoplasms pathology, Breast Neoplasms surgery, Cancer Care Facilities, Cohort Studies, Databases, Factual, Esthetics, Female, Graft Survival, Humans, Mastectomy methods, Middle Aged, Reoperation methods, Retrospective Studies, Risk Assessment, Surgical Flaps blood supply, Transplantation, Autologous methods, Treatment Outcome, United States, Breast Implantation adverse effects, Patient Reported Outcome Measures, Prosthesis Failure, Quality of Life, Surgical Flaps transplantation
- Abstract
Background: There is a subset of patients who initially undergo implant-based breast reconstruction but later change to autologous reconstruction after failure of the implant reconstruction. The purpose of this study was to examine outcomes and quality of life in this group of patients., Methods: After institutional review board approval, a retrospective chart review of a prospectively maintained database was performed and BREAST-Q surveys were evaluated., Results: One hundred thirty-seven patients underwent autologous breast reconstruction following failed implant-based reconstruction with 192 total flaps. Failure of implant reconstruction was defined as follows: capsular contracture causing pain and/or cosmetic deformity [n = 106 (77 percent)], dissatisfaction with the aesthetic result [n = 15 (11 percent)], impending exposure of the implant/infection [n = 8 (6 percent)], and unknown [n = 8 (6 percent)]. Complications requiring operative intervention included partial flap loss [n = 5 (3 percent)], hematoma [n = 5 (3 percent)], vascular compromise requiring intervention for salvage [n = 2 (1 percent)], and total flap loss [n = 1 (1 percent)]. Thirty-four patients (23 percent) had BREAST-Q surveys. There was a statistically significant increase in overall outcomes (p < 0.001), satisfaction with appearance of breasts (p < 0.001), psychosocial well-being (p < 0.001), and physical well-being of the chest (p = 0.003). A statistically significant decrease in physical well-being of the abdomen was observed (p = 0.001)., Conclusions: Autologous breast reconstruction after failed implant-based reconstruction has an acceptable complication rate and is associated with significantly improved patient satisfaction and quality of life., Clinical Question/level of Evidence: Therapeutic, IV.
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- 2019
- Full Text
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58. Impact of Contralateral Symmetry Procedures on Long-Term Patient-Reported Outcomes following Unilateral Prosthetic Breast Reconstruction.
- Author
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Razdan SN, Panchal H, Albornoz CR, Pusic AL, McCarthy CC, Cordeiro PG, Disa JJ, Mehrara BJ, and Matros E
- Subjects
- Adult, Breast surgery, Decision Making, Female, Follow-Up Studies, Humans, Middle Aged, Patient Reported Outcome Measures, Retrospective Studies, Treatment Outcome, Breast anatomy & histology, Breast Implants statistics & numerical data, Esthetics psychology, Mammaplasty methods, Mammaplasty psychology, Mastectomy, Patient Satisfaction statistics & numerical data, Tissue Expansion Devices statistics & numerical data
- Abstract
Background: One aim of unilateral postmastectomy breast reconstruction (BR) is to restore symmetry with the contralateral breast. As such, unilateral prosthetic reconstruction often requires a contralateral symmetry procedure (CSP). There is sparse literature on the impact of CSPs on long-term patient-reported outcomes (PROs) such as satisfaction and health-related quality of life (HRQoL). This study aims to describe PROs following CSPs, using a validated PRO tool, BREAST-Q. The hypothesis is that CSPs are associated with greater patient-reported satisfaction and HRQoL., Methods: This study is a single institutional analysis of prospectively collected BREAST-Q scores of patients who underwent unilateral prosthetic BR during 2011 to 2015. Women 18 years and older with BREAST-Q scores measured ≥ 9months after BR with or without CSP(s) at the time of expander replacement were included. Patients were classified into four subcohorts: augmentation, mastopexy, reduction, and no symmetry procedure (controls). Sociodemographic, clinical characteristics, and BREAST-Q scores were analyzed. Multivariable linear regression was performed., Results: Of 553 patients, 67 (12%) underwent contralateral augmentation, 68 (12%) mastopexy, 93(17%) reduction, and 325 (59%) were controls. Mean follow-up time was 52 months. Satisfaction with breast and outcomes were higher in the augmentation compared with the control groups ( p = 0.01). On multivariable analysis, augmentation remained an independent predictor of satisfaction with breast ( p = 0.04). Physical well-being scores were lower for contralateral mastopexy and reduction compared with the controls with a trend toward statistical significance on multivariable models. Psychological and sexual well-being was similar across groups., Conclusion: Prosthetic reconstruction with contralateral breast augmentation was associated with greater satisfaction with breast and reconstructive outcome. In contrast, breast reduction and mastopexy procedures demonstrated equivalent satisfaction with breasts compared with controls but may be associated with lower physical well-being. Such information can be used to improve the shared decision-making process for women who choose unilateral prosthetic BR., Competing Interests: Disclosure The authors report no conflicts of interest in this work., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
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- 2019
- Full Text
- View/download PDF
59. National trends in contralateral prophylactic mastectomy in women with locally advanced breast cancer.
- Author
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Panchal H, Pilewskie ML, Sheckter CC, Albornoz CR, Razdan SN, Disa JJ, Cordeiro PG, Mehrara BJ, and Matros E
- Subjects
- Adolescent, Adult, Aged, Female, Follow-Up Studies, Humans, Longitudinal Studies, Middle Aged, Prognosis, Retrospective Studies, Unilateral Breast Neoplasms pathology, Young Adult, Prophylactic Mastectomy methods, Prophylactic Mastectomy trends, Unilateral Breast Neoplasms surgery
- Abstract
Background and Objectives: Women with unilateral early-stage breast cancer are increasingly choosing contralateral prophylactic mastectomy (CPM) despite the absence of survival benefits and increased risk of surgical complications. Data are lacking on whether this trend extends to women with clinically locally advanced nonmetastatic (cT4M0) cancer. This study aims to estimate national CPM trends in women with unilateral cT4M0 breast cancer., Methods: Women aged ≥ 18 years, who underwent mastectomy during 2004 to 2014 for unilateral cT4M0 breast cancer were identified using the National Cancer Database and grouped as all locally advanced (T4), chest wall invasion, skin nodule/ulceration, or both (T4abc), and inflammatory (T4d) cancer. Poisson regression for trends and logistic modeling for predictors of CPM were performed., Results: Of 23 943 women, 41% had T4abc disease and 35% T4d. Cumulative CPM rates were 15%, 23%, and 18%, for the T4abc, T4d, and all T4 groups, respectively. Trend analysis revealed a significant upsurge in CPM demonstrating 12% annual growth for T4abc tumors, 8% for T4d and 9% for all T4 (all P < 0.001)., Conclusions: Increasing numbers of women with unilateral cT4M0 breast cancer are undergoing CPM. This rising trend warrants further research to understand stakeholders' preferences in surgical decision-making for women with locally advanced breast cancer., (© 2018 Wiley Periodicals, Inc.)
- Published
- 2019
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60. The Influence of Physician Payments on the Method of Breast Reconstruction: A National Claims Analysis.
- Author
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Sheckter CC, Panchal HJ, Razdan SN, Rubin D, Yi D, Disa JJ, Mehrara B, and Matros E
- Subjects
- Adult, Blue Cross Blue Shield Insurance Plans statistics & numerical data, Female, Humans, Insurance Claim Review, Mammaplasty methods, Mammaplasty statistics & numerical data, Middle Aged, Tissue Expansion Devices statistics & numerical data, United States, Breast Implants statistics & numerical data, Free Tissue Flaps statistics & numerical data, Insurance, Health, Reimbursement statistics & numerical data, Mammaplasty economics
- Abstract
Background: Flap-based breast reconstruction demands greater operative labor and offers superior patient-reported outcomes compared with implants. However, use of implants continues to outpace flaps, with some suggesting inadequate remuneration as one barrier. This study aims to characterize market variation in the ratio of implants to flaps and assess correlation with physician payments., Methods: Using the Blue Health Intelligence database from 2009 to 2013, patients were identified who underwent tissue expander (i.e., implant) or free-flap breast reconstruction. The implant-to-flap ratio and physician payments were assessed using quadratic modeling. Matched bootstrapped samples from the early and late periods generated probability distributions, approximating the odds of surgeons switching reconstructive method., Results: A total of 21,259 episodes of breast reconstruction occurred in 122 U.S. markets. The distribution of implant-to-flap ratio varied by market, ranging from the fifth percentile at 1.63 to the ninety-fifth percentile at 43.7 (median, 6.19). Modeling the implant-to-flap ratio versus implant payment showed a more elastic quadratic equation compared with the function for flap-to-implant ratio versus flap payment. Probability modeling demonstrated that switching the reconstructive method from implants to flaps with a 0.75 probability required a $1610 payment increase, whereas switching from flaps to implants at the same certainty occurred at a loss of $960., Conclusions: There was a correlation between the ratio of flaps to implants and physician reimbursement by market. Switching from implants to flaps required large surgeon payment increases. Despite a relative value unit schedule over twice as high for flaps, current flap reimbursements do not appear commensurate with physician effort.
- Published
- 2018
- Full Text
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61. Clinical and Quantitative Isokinetic Comparison of Abdominal Morbidity and Dynamics following DIEP versus Muscle-Sparing Free TRAM Flap Breast Reconstruction.
- Author
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Nelson JA and Disa JJ
- Subjects
- Abdomen, Postoperative Complications, Retrospective Studies, Mammaplasty, Rectus Abdominis
- Published
- 2018
- Full Text
- View/download PDF
62. Discussion: Motiva Ergonomix Round SilkSurface Silicone Breast Implants: Outcome Analysis of 100 Primary Breast Augmentations over 3 Years and Technical Considerations.
- Author
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Disa JJ
- Subjects
- Mammaplasty, Prosthesis Design, Silicone Gels, Breast Implantation, Breast Implants
- Published
- 2018
- Full Text
- View/download PDF
63. Discussion: The Cost of Contralateral Prophylactic Mastectomy in Women with Unilateral Breast Cancer.
- Author
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Matros E and Disa JJ
- Subjects
- Breast Neoplasms surgery, Female, Humans, Mammaplasty, Mastectomy, Prophylactic Mastectomy, Unilateral Breast Neoplasms
- Published
- 2018
- Full Text
- View/download PDF
64. Trends in Physician Payments for Breast Reconstruction.
- Author
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Sheckter CC, Yi D, Panchal HJ, Razdan SN, Pusic AL, McCarthy CM, Cordeiro PG, Disa JJ, Mehrara B, and Matros E
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Breast Implants economics, Breast Implants statistics & numerical data, Databases, Factual, Female, Free Tissue Flaps economics, Free Tissue Flaps statistics & numerical data, Humans, Linear Models, Mammaplasty instrumentation, Mammaplasty trends, Middle Aged, Practice Patterns, Physicians' trends, Tissue Expansion economics, Tissue Expansion instrumentation, Tissue Expansion trends, Tissue Expansion Devices economics, Tissue Expansion Devices statistics & numerical data, United States, Young Adult, Insurance, Health, Reimbursement trends, Mammaplasty economics, Mammaplasty methods, Practice Patterns, Physicians' economics
- Abstract
Background: Prosthetic breast reconstruction rates have risen in the United States, whereas autologous techniques have stagnated. Meanwhile, single-institution data demonstrate that physician payments for prosthetic reconstruction are rising, while payments for autologous techniques are unchanged. This study aims to assess payment trends and variation for tissue expander and free flap breast reconstruction., Methods: The Blue Health Intelligence database was queried from 2009 to 2013, identifying women with claims for breast reconstruction. Trends in the incidence of surgery and physician reimbursement were characterized by method and year using regression models., Results: There were 21,259 episodes of breast reconstruction, with a significant rise in tissue expander cases (incidence rate ratio, 1.09; p < 0.001) and an unchanged incidence of free flap cases (incidence rate ratio, 1.02; p = 0.222). Bilateral tissue expander cases reimbursed 1.32 times more than unilateral tissue expanders, whereas bilateral free flaps reimbursed 1.61 times more than unilateral variants. The total growth in adjusted tissue expander mean payments was 6.5 percent (from $2232 to $2378) compared with -1.8 percent (from $3858 to $3788) for free flaps. Linear modeling showed significant increases for tissue expander reimbursements only. Surgeon payments varied more for free flaps (the 25th to 75th percentile interquartile range was $2243 for free flaps versus $987 for tissue expanders)., Conclusions: The incidence of tissue expander cases and reimbursements rose over a period where the incidence of free flap cases and reimbursements plateaued. Reasons for stagnation in free flaps are unclear; however, the opportunity cost of performing this procedure may incentivize the alternative technique. Greater payment variation in autologous reconstruction suggests the opportunity for negotiation with payers.
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- 2018
- Full Text
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65. The Functional Impact of Breast Reconstruction: An Overview and Update.
- Author
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Nelson JA, Lee IT, and Disa JJ
- Abstract
As rates of bilateral mastectomy and immediate reconstruction rise, the aesthetic and psychosocial benefits of breast reconstruction are increasingly well understood. However, an understanding of functional outcome and its optimization is still lacking. This endpoint is critical to maximizing postoperative quality of life. All reconstructive modalities have possible functional consequences. Studies demonstrate that implant-based reconstruction impacts subjective movement, but patients' day-to-day function may not be objectively hindered despite self-reported disability. For latissimus dorsi flap reconstruction, patients also report some dysfunction at the donor site, but this does not seem to result in significant, long-lasting limitation of daily activity. Athletic and other vigorous activities are most affected. For abdominal free flaps, patient perception of postoperative disability is generally not significant, despite the varying degrees of objective disadvantage that have been identified depending on the extent of rectus muscle sacrifice. With these functional repercussions in mind, a broader perspective on the attempt to ensure minimal functional decline after breast surgery should focus not only on surgical technique but also on postoperative rehabilitation. Early directed physical therapy may be an instrumental element in facilitating return to baseline function. With the patient's optimal quality of life as an overarching objective, a multifaceted approach to functional preservation may be the answer to this continued challenge. This review will examine these issues in depth in an effort to better understand postoperative functional outcomes with a focus on the younger, active breast reconstruction patient., Competing Interests: Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the author’s institutional service at Memorial Sloan Kettering.
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- 2018
- Full Text
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66. Conceptual Considerations for Payment Bundling in Breast Reconstruction.
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Sheckter CC, Razdan SN, Disa JJ, Mehrara BJ, and Matros E
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- Centers for Medicare and Medicaid Services, U.S. economics, Costs and Cost Analysis economics, Costs and Cost Analysis methods, Costs and Cost Analysis statistics & numerical data, Fee-for-Service Plans legislation & jurisprudence, Humans, Inventions economics, Mammaplasty instrumentation, Mammaplasty methods, Mammaplasty statistics & numerical data, Quality Improvement economics, United States, Centers for Medicare and Medicaid Services, U.S. legislation & jurisprudence, Fee-for-Service Plans economics, Health Care Costs statistics & numerical data, Health Care Reform economics, Mammaplasty economics
- Abstract
Rising health care costs and quality demands have driven both the Centers for Medicare and Medicaid Services and the private sector to seek innovations in health system design by placing institutions at financial risk. Novel care models, such as bundled reimbursement, aim to boost value though quality improvement and cost reduction. The Center for Medicare and Medicaid Innovation is leading the charge in this area with multiple pilots and mandates, including Comprehensive Care for Joint Replacement. Other high-cost and high-volume procedures could be considered for bundling in the future, including breast reconstruction. In this article, conceptual considerations surrounding bundling of breast reconstruction are discussed.
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- 2018
- Full Text
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67. Breast Reconstruction and Radiation Therapy: An Update.
- Author
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Nelson JA and Disa JJ
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- Female, Humans, Patient Satisfaction, Radiotherapy, Adjuvant methods, Breast Neoplasms radiotherapy, Breast Neoplasms surgery, Mammaplasty methods, Mastectomy
- Abstract
With the indications for radiation therapy in the treatment of breast cancer continuing to expand, many patients present for reconstruction having previously had radiation or having a high likelihood of requiring radiation following mastectomy. Both situations are challenging for the plastic surgeon, with different variables impacting the surgical outcome. To date, multiple studies have been performed examining prosthetic and autologous reconstruction in this setting. The purpose of this article was to provide a general platform for understanding the literature as it relates to reconstruction and radiation through an examination of recent systematic reviews and relevant recent publications. We examined this with a focus on the timing of the radiation, and within this context, examined the data from the traditional surgical outcomes standpoint as well as from a patient-reported outcomes perspective. The data provided within will aid in patient counseling and the informed consent process.
- Published
- 2017
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68. Introduction to "Advances in Breast Reconstruction".
- Author
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Kim JYS, Colwell AS, and Disa JJ
- Subjects
- Female, Humans, Mastectomy, Breast Neoplasms surgery, Mammaplasty methods
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- 2017
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69. The Impact of the Cosurgeon Model on Bilateral Autologous Breast Reconstruction.
- Author
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Razdan SN, Panchal HJ, Hespe GE, Disa JJ, McCarthy CM, Allen RJ Jr, Dayan JH, Pusic A, Mehrara B, Cordeiro PG, and Matros E
- Subjects
- Adult, Female, Humans, Middle Aged, Operative Time, Postoperative Complications physiopathology, Postoperative Complications surgery, Retrospective Studies, Treatment Outcome, United States epidemiology, Mammaplasty methods, Postoperative Complications epidemiology, Reoperation statistics & numerical data, Surgical Flaps transplantation
- Abstract
Competing Interests: Conflict of Interest: None of the authors has a financial/conflict of interest in any of the products, devices, or drugs mentioned in this article.
- Published
- 2017
- Full Text
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70. Reconstruction of Peripelvic Oncologic Defects.
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Weichman KE, Matros E, and Disa JJ
- Subjects
- Female, Humans, Male, Perineum surgery, Pelvic Neoplasms surgery, Pelvis surgery, Penis surgery, Plastic Surgery Procedures methods, Scrotum surgery, Surgical Flaps, Vagina surgery
- Abstract
Learning Objectives: After studying this article, the participant should be able to: 1. Understand the anatomy of the peripelvic area. 2. Understand the advantages and disadvantages of performing peripelvic reconstruction in patients undergoing oncologic resection. 3. Select the appropriate local, pedicled, or free-flap reconstruction based on the location of the defect and donor-site characteristics., Summary: Peripelvic reconstruction most commonly occurs in the setting of oncologic ablative surgery. The peripelvic area contains several distinct reconstructive regions, including vagina, vulva, penis, and scrotum. Each area provides unique reconstructive considerations. In addition, prior or future radiation therapy or chemotherapy along with cancer cachexia can increase the complexity of reconstruction.
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- 2017
- Full Text
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71. National Breast Reconstruction Utilization in the Setting of Postmastectomy Radiotherapy.
- Author
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Razdan SN, Cordeiro PG, Albornoz CR, Disa JJ, Panchal HJ, Ho AY, Momoh AO, and Matros E
- Subjects
- Adult, Databases, Factual, Decision Making, Female, Follow-Up Studies, Humans, Mammaplasty trends, Mastectomy, Practice Patterns, Physicians', Quality of Life, Retrospective Studies, Time Factors, Treatment Outcome, United States, Breast Implants statistics & numerical data, Breast Neoplasms radiotherapy, Breast Neoplasms surgery, Mammaplasty methods, Mammaplasty statistics & numerical data, Radiotherapy, Adjuvant statistics & numerical data
- Abstract
Background Immediate breast reconstruction (IBR) is often deferred, when postmastectomy radiotherapy (PMRT) is anticipated, due to high complication rates. Nonetheless, because of robust data supporting improved health-related quality of life associated with reconstruction, physicians and patients may be more accepting of tradeoffs. The current study explores national trends of IBR utilization rates and methods in the setting of PMRT, using the National Cancer Database (NCDB). The study hypothesis is that prosthetic techniques have become the most common method of IBR in the setting of PMRT. Methods NCDB was queried from 2004 to 2013 for women, who underwent mastectomy with or without IBR. Patients were grouped according to PMRT status. Multivariate logistic regression was used to calculate odds of IBR in the setting of PMRT. Trend analyses were done for rates and methods of IBR using Poisson regression to determine incidence rate ratios (IRRs). Results In multivariate analysis, radiated patients were 30% less likely to receive IBR ( p < 0.05). The rate increase in IBR was greater in radiated compared with nonradiated patients (IRR: 1.12 vs. 1.09). Rates of reconstruction increased more so in radiated compared with nonradiated patients for both implants (IRR 1.15 vs. 1.11) and autologous techniques (IRR 1.08 vs. 1.06). Autologous reconstructions were more common in those receiving PMRT until 2005 ( p < 0.05), with no predominant technique thereafter. Conclusion Although IBR remains a relative contraindication, rates of IBR are increasing to a greater extent in patients receiving PMRT. Implants have surpassed autologous techniques as the most commonly used method of breast reconstruction in this setting., Competing Interests: Conference Presentation: Abstract of this study has been accepted for oral presentation at 33rd Annual Meeting of Northeastern Society of Plastic Surgeons Scheduled on October 14, 2016. Disclosure None of the authors reports a financial interest in any of the products, devices, or drugs mentioned in this manuscript., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
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- 2017
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72. Is Enhanced Recovery the New Standard of Care in Microsurgical Breast Reconstruction?
- Author
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Afonso A, Oskar S, Tan KS, Disa JJ, Mehrara BJ, Ceyhan J, and Dayan JH
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- Critical Pathways, Female, Humans, Middle Aged, Retrospective Studies, Mammaplasty methods, Microsurgery, Postoperative Care standards, Standard of Care, Surgical Flaps
- Abstract
Background: At present, there are limited data available regarding the use and feasibility of enhanced recovery pathways for patients undergoing microsurgical breast reconstruction. The authors sought to assess patient outcomes before and after the introduction of an enhanced recovery pathway that was adopted at a single cancer center., Methods: A multidisciplinary enhanced recovery pathway was developed for patients undergoing deep inferior epigastric perforator or free transverse rectus abdominis myocutaneous flap breast reconstruction. Core elements of the enhanced recovery pathway included substituting intravenous patient-controlled analgesia with ketorolac and transversus abdominis plane blocks using liposomal bupivacaine, as well as intraoperative goal-directed fluid management. Patients who underwent surgery between April and August of 2015 using the enhanced recovery pathway were compared with a historical control cohort. The primary endpoints were hospital length of stay and total postoperative opioid consumption., Results: In total, 91 consecutive patients were analyzed (enhanced recovery pathway, n = 42; pre-enhanced recovery pathway, n = 49). Mean hospital length of stay was significantly shorter in the enhanced recovery pathway group than in the pre-enhanced recovery pathway group (4.0 days versus 5.0 days; p < 0.0001). Total postoperative morphine equivalent consumption was also lower in the enhanced recovery pathway group (46.0 mg versus 70.5 mg; p = 0.003). There was no difference in the incidence of 30-day complications between the groups (p = 0.6)., Conclusion: The adoption of an enhanced recovery pathway for deep inferior epigastric perforator and transverse rectus abdominis myocutaneous flap reconstruction by multiple surgeons significantly decreased opioid consumption and reduced length of stay by 1 day., Clinical Question/level of Evidence: Therapeutic, III.
- Published
- 2017
- Full Text
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73. Technical Tip: Mark Scarpa's Fascia to Facilitate Proper Abdominal Closure During Autologous Breast Reconstruction.
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Henderson PW, Dent BL, and Disa JJ
- Published
- 2017
- Full Text
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74. Discussion: Reconstruction of the Irradiated Breast: A National Claims-Based Assessment of Postoperative Morbidity.
- Author
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Disa JJ and Matros E
- Subjects
- Breast Neoplasms surgery, Humans, Morbidity, Postoperative Complications surgery, Retrospective Studies, Breast surgery, Mammaplasty
- Published
- 2017
- Full Text
- View/download PDF
75. Discussion: Risk Factor Analysis for Capsular Contracture, Malposition, and Late Seroma in Subjects Receiving Natrelle 410 Form-Stable Silicone Breast Implants.
- Author
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Disa JJ
- Subjects
- Breast Implantation, Contracture, Factor Analysis, Statistical, Humans, Prosthesis Design, Silicone Gels, Breast Implants, Seroma
- Published
- 2017
- Full Text
- View/download PDF
76. Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
- Author
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Connolly KL, Nehal KS, and Disa JJ
- Subjects
- Carcinoma, Basal Cell diagnosis, Carcinoma, Basal Cell therapy, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell therapy, Diagnosis, Differential, Evidence-Based Medicine, Humans, Facial Neoplasms diagnosis, Facial Neoplasms therapy, Skin Neoplasms diagnosis, Skin Neoplasms therapy
- Abstract
Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Define appropriate management based on current guidelines for various types of basal cell and squamous cell carcinoma., Summary: Skin malignancies are the most prevalent cancers, and plastic surgeons are often the primary physicians engaged in diagnosis and management of these lesions. Proper management includes distinguishing between high-risk and low-risk lesions and determining treatment accordingly. The aim of this Continuing Medical Education article is to review the diagnosis and management of common and uncommon facial skin malignancies, including basal cell carcinoma, squamous cell carcinoma, actinic keratosis, keratoacanthoma, Merkel cell carcinoma, atypical fibroxanthoma, sebaceous carcinoma, and microcystic adnexal carcinoma.
- Published
- 2017
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77. Discussion: Suprafascial Anterolateral Thigh Flap Harvest: A Better Way to Minimize Donor-Site Morbidity in Head and Neck Reconstruction.
- Author
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Allen RJ Jr and Disa JJ
- Subjects
- Humans, Head and Neck Neoplasms surgery, Surgical Flaps, Thigh, Tissue and Organ Harvesting methods
- Published
- 2016
- Full Text
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78. Successful Salvage of Late Anastomotic Thrombosis after Free Tissue Transfer.
- Author
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Henderson PW, Fernandez JG, Cemal Y, Mehrara BJ, Pusic AL, McCarthy CM, Matros E, Cordeiro PG, and Disa JJ
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Graft Survival, Humans, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Treatment Outcome, Free Tissue Flaps adverse effects, Plastic Surgery Procedures adverse effects, Salvage Therapy methods, Venous Thrombosis surgery
- Abstract
Background Anastomotic thrombosis following free tissue transfer (FTT) on or after day 5 ("late thrombosis") is reported to have extremely low rates of salvage. Analysis of our institution's experience with FTT was performed to make recommendations about the optimal management of late thrombosis, and to identify any variables that are correlated with increased salvage rates. Methods The study included patients who underwent FTT between 1986 and 2014, then suffered anastomotic thrombosis on or after postoperative day 5. Twenty-six variables involving demographic information, flap characteristics, circumstances of the thrombotic event, and details of any salvage attempt were analyzed. Patients whose FTT were successfully salvaged and those whose were not were statistically compared. Results Of the 3,212 patients who underwent FTT, 23 suffered late thrombosis (0.7%), and the salvage rate was 60.8% (14 of 23). The salvage rate for reconstruction of the head and neck was 53.3%, breast was 66.7%, and extremity was 100%. There was a statistically significantly greater salvage rate in flaps performed after 1998 than in those performed before 1998 (p = 0.023). There was a nonstatistically significant trend toward increased salvage rates in patients who had no anastomotic thrombotic risk factors, reconstruction using fasciocutaneous flaps, and anastomotic revision using new recipient vessels. Conclusion Our data demonstrate that flap survival after episodes of late thrombosis can be higher than what the literature has previously reported. This underscores the importance of rigorous postoperative monitoring, as well as the importance of exploration at the earliest instance of concern for threatened flap viability., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
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- 2016
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79. Cost-Effectiveness Analysis of Breast Reconstruction Options in the Setting of Postmastectomy Radiotherapy Using the BREAST-Q.
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Razdan SN, Cordeiro PG, Albornoz CR, Ro T, Cohen WA, Mehrara BJ, McCarthy CM, Disa JJ, Pusic AL, and Matros E
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- Adult, Aged, Breast Implants economics, Breast Neoplasms etiology, Breast Neoplasms mortality, Breast Neoplasms pathology, Cancer Care Facilities, Cross-Sectional Studies, Decision Trees, Disease-Free Survival, Female, Humans, Mastectomy methods, Middle Aged, New York City, Quality-Adjusted Life Years, Radiotherapy, Adjuvant, Surgical Flaps blood supply, Surgical Flaps transplantation, Survival Analysis, Transplantation, Autologous, Breast Neoplasms surgery, Cost-Benefit Analysis, Mammaplasty economics, Mammaplasty methods, Surgical Flaps economics, Surveys and Questionnaires
- Abstract
Background: A consensus is lacking on a uniform reconstructive algorithm for patients with locally advanced breast cancer who require postmastectomy radiotherapy. Both delayed autologous and immediate prosthetic techniques have inherent advantages and complications. The study hypothesis is that implants are more cost effective than autologous reconstruction in the setting of postmastectomy radiotherapy because of immediate restoration of the breast mound., Methods: A cost-effectiveness analysis model using the payer perspective was created comparing delayed autologous and immediate prosthetic techniques against the do-nothing option of mastectomy without reconstruction. Costs were obtained from the 2010 Nationwide Inpatient Sample database. Effectiveness was determined using the BREAST-Q patient-reported outcome measure. A breast quality-adjusted life-year value was considered 1 year of perfect breast health-related quality of life. The incremental cost-effectiveness ratio was calculated for both treatments compared with the do-nothing option., Results: BREAST-Q scores were obtained from patients who underwent immediate prosthetic reconstruction (n = 196), delayed autologous reconstruction (n = 76), and mastectomy alone (n = 71). The incremental cost-effectiveness ratios for immediate prosthetic and delayed autologous reconstruction compared with mastectomy alone were $57,906 and $102,509, respectively. Sensitivity analysis showed that the incremental cost-effectiveness ratio for both treatment options decreased with increasing life expectancy., Conclusions: For patients with advanced breast cancer who require postmastectomy radiotherapy, immediate prosthetic-based breast reconstruction is a cost-effective approach. Despite high complication rates, implant use can be rationalized based on low cost and health-related quality-of-life benefit derived from early breast mound restoration. If greater life expectancy is anticipated, autologous transfer is cost effective as well and may be a superior option.
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- 2016
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80. Venous Thrombosis in Handsewn versus Coupled Venous Anastomoses in 857 Consecutive Breast Free Flaps.
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Kulkarni AR, Mehrara BJ, Pusic AL, Cordeiro PG, Matros E, McCarthy CM, and Disa JJ
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- Female, Humans, Retrospective Studies, Suture Techniques, Vascular Patency, Anastomosis, Surgical instrumentation, Intraoperative Complications epidemiology, Mammaplasty instrumentation, Microsurgery instrumentation, Surgical Flaps, Venous Thrombosis epidemiology
- Abstract
Background: The anastomotic coupling device has demonstrated safety and efficacy; however, the coupler has never been compared directly to handsewn venous anastomoses exclusively in breast reconstruction. We hypothesized that rates of venous thrombosis would be lower using the coupler versus handsewn anastomoses in free flap breast reconstruction., Methods: We performed a retrospective review utilizing clinic records, hospital records, and operative reports for 857 consecutive breast free flaps at a single institution from 1997 to 2012. Data were collected on reconstruction type, recipient vessels, timing, laterality, preoperative radiation, chemotherapy, venous thrombosis, and flap outcome. We compared rates of venous thrombosis between handsewn and coupled anastomoses for breast free flaps. Chi-square test was used to calculate statistical significance., Results: A total of 857 consecutive free flaps were performed for breast reconstruction in 647 patients over 16 years. The venous anastomosis was handsewn in 303 flaps, and the anastomotic coupler was used in 554 flaps. The rate of venous thrombosis requiring anastomotic revision in the handsewn group was 0.04% (12/303), compared with 0.01% in the coupled group (8/554; p = 0.02)., Conclusion: The anastomotic coupler was more effective in preventing venous thrombosis than handsewn anastomoses in our series. While our study demonstrates improved patency rates using the venous coupler in breast reconstruction, we were unable to definitively separate this finding from potential confounding variables due to the low rates of thrombosis in both the groups. Our data are consistent with current literature, which suggests that the coupler is a safe and effective alternative to hand sutured anastomoses., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
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- 2016
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81. Psychosocial and Sexual Well-Being Following Nipple-Sparing Mastectomy and Reconstruction.
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Wei CH, Scott AM, Price AN, Miller HC, Klassen AF, Jhanwar SM, Mehrara BJ, Disa JJ, McCarthy C, Matros E, Cordeiro PG, Sacchini V, and Pusic AL
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- Adult, Aged, Breast Implants, Female, Humans, Mammaplasty methods, Mastectomy, Subcutaneous methods, Middle Aged, Patient Satisfaction, Quality of Life, Breast Neoplasms psychology, Breast Neoplasms surgery, Mammaplasty psychology, Mastectomy, Subcutaneous psychology, Nipples surgery
- Abstract
Nipple-sparing mastectomy (NSM) is considered an oncologically safe option for select patients. As many patients are candidates for nipple-sparing or skin-sparing mastectomy (SSM), reliable patient-reported outcome data are crucial for decision-making. The objective of this study was to determine whether patient satisfaction and/or health-related quality of life (HRQOL) were improved by preservation of the nipple with NSM compared to SSM and nipple reconstruction. Subjects were identified from a prospectively maintained database of patients who completed the BREAST-Q following mastectomy and breast reconstruction between March and October 2011 at Memorial Sloan Kettering Cancer Center. Fifty-two patients underwent NSM followed by immediate expander-implant reconstruction. A comparison group consisted of 202 patients who underwent SSM followed by immediate expander-implant reconstruction and later nipple reconstruction. HRQOL and satisfaction domains as measured by BREAST-Q scores were compared in multivariate linear regression analyzes that controlled for potential confounding factors. NSM patients reported significantly higher scores in the psychosocial (p = 0.01) and sexual well-being (p = 0.02) domains compared to SSM patients. There was no significant difference in the BREAST-Q physical well-being, satisfaction with breast, or satisfaction with outcome domains between the NSM and SSM groups. NSM is associated with higher psychosocial and sexual well-being compared to SSM and nipple reconstruction. Preoperative discussion of such HRQOL outcomes with patients may facilitate informed decision-making and realistic postoperative expectations., (© 2015 Wiley Periodicals, Inc.)
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- 2016
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82. The Impact of Travel Distance on Breast Reconstruction in the United States.
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Albornoz CR, Cohen WA, Razdan SN, Mehrara BJ, McCarthy CM, Disa JJ, Dayan JH, Pusic AL, Cordeiro PG, and Matros E
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- Adult, Breast Neoplasms pathology, Databases, Factual, Female, Geography, Health Services Accessibility statistics & numerical data, Healthcare Disparities statistics & numerical data, Humans, Insurance Coverage, Mammaplasty methods, Mammaplasty statistics & numerical data, Mastectomy methods, Middle Aged, Patient Protection and Affordable Care Act, Retrospective Studies, Risk Assessment, United States, Women's Health, Breast Neoplasms surgery, Health Services Needs and Demand, Healthcare Disparities economics, Mammaplasty economics, Travel
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Background: Inadequate access to breast reconstruction was a motivating factor underlying passage of the Women's Health and Cancer Rights Act. It remains unclear whether all patients interested in breast reconstruction undergo this procedure. The aim of this study was to determine whether geographic disparities are present that limit the rate and method of postmastectomy reconstruction., Methods: Travel distance in miles between the patient's residence and the hospital reporting the case was used as a quantitative measure of geographic disparities. The American College of Surgeons National Cancer Database was queried for mastectomy with or without reconstruction performed from 1998 to 2011. Reconstructive procedures were categorized as implant or autologous techniques. Standard statistical tests including linear regression were performed., Results: Patients who underwent breast reconstruction had to travel farther than those who had mastectomy alone (p < 0.01). A linear correlation was demonstrated between travel distance and reconstruction rates (p < 0.01). The mean distances traveled by patients who underwent reconstruction at community, comprehensive community, or academic programs were 10.3, 19.9, and 26.2 miles, respectively (p < 0.01). Reconstruction rates were significantly greater at academic programs. Patients traveled farther to undergo autologous compared with prosthetic reconstruction., Conclusions: Although greater patient awareness and insurance coverage have contributed to increased breast reconstruction rates in the United States, the presence of geographic barriers suggests an unmet need. Academic programs have the greatest reconstruction rates, but are located farther from patients' residences. Increasing the number of plastics surgeons, especially in community centers, would be one method of addressing this inequality.
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- 2016
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83. The value of postoperative anticoagulants to improve flap survival in the free radial forearm flap: a systematic review and retrospective multicentre analysis.
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Swartz JE, Aarts MC, Swart KM, Disa JJ, Gerressen M, Kuo YR, Wax MK, Grolman W, and Braunius WW
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- Forearm surgery, Head and Neck Neoplasms surgery, Humans, Retrospective Studies, Anticoagulants therapeutic use, Free Tissue Flaps, Graft Survival drug effects, Multicenter Studies as Topic, Postoperative Care methods, Plastic Surgery Procedures methods
- Abstract
Background: Free radial forearm flap (FRFF) reconstruction is a valuable technique in head and neck surgery, which allows closure of large defects while striving to maintain functionality. Anticoagulative drugs are often administered to improve flap survival, although evidence regarding effectiveness is lacking., Objective of Review: To investigate the effectiveness of postoperative anticoagulants to improve survival of the FRFF in head and neck reconstruction., Type of Review: Systematic review and multicentre, individual patient data meta-analysis., Search Strategy: MEDLINE, EMBASE, Web of Science and CINAHL were searched for synonyms of 'anticoagulants' and 'free flap reconstruction'., Evaluation Method: Studies were critically appraised for directness of evidence and risk of bias. Authors of the highest quality publications were invited to submit their original data for meta-analysis., Results: Five studies were of adequate quality, and data from four studies (80%) were available for meta-analysis, describing 759 FRFF procedures. Anticoagulants used were as follows: aspirin (12%), low molecular weight dextran (18.3%), unfractioned heparin (28.1%), low molecular weight heparin (49%) and prostaglandin-E1 (2.1%). Thirty-one per cent did not receive anticoagulants. Flap failure occurred in 40 of 759 patients (5.3%) On univariate analysis, use of unfractioned heparin was associated with a higher rate of flap failure. However, these regimens were often administered to patients who had revision surgery of the anastomosis. In multivariate logistic regression analysis, anticoagulant use was not associated with improved flap survival or flap-related complications., Conclusions: The studied anticoagulative drugs did not improve FRFF survival or lower the rate of flap-related complications. In addition, some anticoagulants may cause systemic complications., Competing Interests: Conflicts of Interest: None declared, (© 2015 John Wiley & Sons Ltd.)
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- 2015
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84. Satisfaction following Unilateral Breast Reconstruction: A Comparison of Pedicled TRAM and Free Abdominal Flaps.
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Schwitzer JA, Miller HC, Pusic AL, Matros E, Mehrara BJ, McCarthy CM, Lennox PA, Van Laeken N, and Disa JJ
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Background: The purpose of this study was to compare patient satisfaction following unilateral pedicled transverse rectus abdominis myocutaneous (TRAM) and free abdominal flap reconstruction., Methods: Patients who underwent unilateral breast reconstruction using pedicled TRAM or free abdominal flaps (muscle-sparing TRAM or deep inferior epigastric perforator flap) and completed the BREAST-Q were identified from 2 prospectively maintained databases. BREAST-Q scores were assessed and compared for Satisfaction with Breasts, Outcome, and Physical Well-being Chest/Abdomen., Results: Of the 138 patients who completed the BREAST-Q, 84 underwent pedicled TRAM flap reconstruction and 54 underwent free abdominal flap reconstruction. Overall, pedicled TRAM flap patients scored higher than free abdominal flap patients on all 4 BREAST-Q scales. This difference reached statistical significance in Satisfaction with Breasts (+7.74; P = 0.02). Similar results were found among patients who completed the BREAST-Q at <3 years postoperation. However, among patients at ≥3 years postoperation, there were no statistically significant differences between the 2 groups, with the pedicled flap cohort scoring higher in Satisfaction with Breasts and Physical Well-being Chest and the free abdominal flap cohort scoring higher in Satisfaction with Outcome and Physical Well-being Abdomen scores., Conclusions: Patients who underwent unilateral pedicled TRAM flap reconstruction experienced greater initial breast satisfaction than patients who underwent unilateral free abdominal flap reconstruction, but satisfaction equalized between the two over time, suggesting that long-term satisfaction may be equivalent between the 2 methods of reconstruction.
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- 2015
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85. Lower Extremity Osseous Oncologic Reconstruction with Composite Microsurgical Free Fibula Inside Massive Bony Allograft.
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Weichman KE, Dec W, Morris CD, Mehrara BJ, and Disa JJ
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- Adolescent, Adult, Allografts, Bone Neoplasms pathology, Child, Child, Preschool, Cohort Studies, Female, Femur pathology, Fibula blood supply, Follow-Up Studies, Graft Rejection, Graft Survival, Humans, Male, Microsurgery methods, Middle Aged, Retrospective Studies, Risk Assessment, Tibia pathology, Treatment Outcome, Young Adult, Bone Neoplasms surgery, Bone Transplantation methods, Femur surgery, Fibula transplantation, Plastic Surgery Procedures methods, Tibia surgery
- Abstract
Background: Lower extremity reconstruction after resection of long bone tumors in children is challenging because of the unique functional demands and growth potential of the lower extremity. The use of a free fibula flap inside a massive bone allograft provides a reliable reconstructive option. The authors evaluate the surgical and functional outcomes of using this technique., Methods: This is a retrospective review of 12 consecutive patients who underwent reconstruction of segmental femur or tibia defects using a free fibula flap inside a massive bone allograft between 2003 and 2011. Complications and functional outcomes are reported., Results: Twelve patients with a mean age of 15.8 years (range, 3 to 49 years) were included in the study. Eight femur defects and four tibia defects were reconstructed. The mean follow-up time was 41.4 months. Two constructs were removed because of infection, three patients required bone grafting for nonunion, one patient required an additional operation to excise a skin paddle, and one patient experienced a lower extremity deep vein thrombosis. The mean time to achieve full weight bearing was 14.3 months., Conclusions: The use of a free fibula flap inside a massive bone allograft after bone tumor resection provides an option for lower extremity reconstruction. The allograft component increases the initial strength of the reconstruction, whereas the vascularized fibula component is thought to increase the biologic potential for osteosynthesis and ultimately provide a potentially lifelong durable reconstruction. Patients who achieve oncologic control are likely to enjoy a highly functional long-term outcome., Clinical Question/level of Evidence: Therapeutic, IV.
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- 2015
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86. Safety of the supraclavicular artery island flap in the setting of neck dissection and radiation therapy.
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Razdan SN, Albornoz CR, Ro T, Cordeiro PG, Disa JJ, McCarthy CM, Stern CS, Garfein ES, and Matros E
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- Aged, Aged, 80 and over, Arteries, Female, Head and Neck Neoplasms pathology, Humans, Laryngeal Neoplasms pathology, Laryngeal Neoplasms surgery, Lymph Node Excision, Male, Middle Aged, Pharyngeal Neoplasms pathology, Pharyngeal Neoplasms surgery, Retrospective Studies, Clavicle blood supply, Head and Neck Neoplasms surgery, Plastic Surgery Procedures methods, Surgical Flaps
- Abstract
Background: The supraclavicular artery island flap (SAIF) has recently been repopularized as a versatile and reliable option for reconstruction of oncological head and neck defects. Prior ipsilateral neck dissection or irradiation is considered a relative contraindication to its use. The aim of this study was to describe the safety and utility of the SAIF for head and neck reconstruction in the setting of neck dissection and radiation., Methods: A retrospective chart review was performed of consecutive SAIF reconstructions at two institutions between May 2011 and 2014. In addition to demographic data, comorbidities, indications, surgical characteristics, data about radiation treatment, and neck dissection were specifically recorded. Donor and recipient site complications were noted. Fisher exact test was performed to analyze if neck dissection or radiation were associated with complications., Results: A total of 22 patients underwent SAIF reconstruction for an array of head and neck defects. Donor site infection was noted in one patient. Recipient site complications included, wound dehiscence (n = 2), orocutaneous fistula (n = 1), carotid blowout (n = 1), and total flap loss (n = 1). There was no association between prior neck dissection or radiation treatment and flap loss (p = 1.00)., Conclusion: The SAIF is safe for use in patients who have had an ipsilateral neck dissection involving level IV or V lymph nodes and/or radiation treatment to the neck. It can be used alone or in combination with other flaps for closure of a variety of head and neck defects., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
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- 2015
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87. Breast reduction in patients with prior breast irradiation: outcomes using a central mound technique.
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Weichman KE, Urbinelli L, Disa JJ, and Mehrara BJ
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- Adult, Breast Neoplasms surgery, Female, Follow-Up Studies, Humans, Mastectomy, Middle Aged, Nipples surgery, Retrospective Studies, Treatment Outcome, Breast Neoplasms radiotherapy, Mammaplasty methods
- Abstract
Background: Breast reduction in patients with a history of lumpectomy and irradiation is controversial because of a heightened risk of infection and wound healing complications. Persistent macromastia or asymmetry remains a problem in this patient population that is commonly not addressed. The authors studied the safety and efficacy of a central mound technique with minimal dissection for breast reduction or mastopexy in patients with a history of breast irradiation., Methods: A case-control study of all patients undergoing bilateral breast reduction mammaplasty between 2008 and 2013 at Memorial Sloan Kettering Cancer Center was conducted. Patients who had unilateral breast irradiation and bilateral reduction using the central mound technique were included. Each patient had a control breast and an irradiated breast. Complications and outcomes were analyzed., Results: Thirteen patients were included for analysis. Their average age was 50.23 ± 9.9 years, and average time from irradiation to breast reduction mammaplasty was 41.3 ± 48.5 months (range, 9 to 132 months). The average specimen weight of irradiated breasts was less than that of control breasts; however, this failed to reach statistical significance (254.2 ± 173.5 g versus 386.9 ± 218.5 g; p = 0.099). One patient developed fat necrosis in the previously irradiated breast and underwent biopsy. There was no incidence of nipple necrosis or breast cancer in either irradiated or nonirradiated breasts., Conclusions: Breast reduction mammaplasty in patients who have had irradiation is feasible and can be performed safely in select cases. The central mound technique provides reliable and reproducible results and should be considered in patients with macromastia/asymmetry and a history of irradiation., Clinical Question/level of Evidence: Therapeutic, III.
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- 2015
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88. Cost-effectiveness analysis of implants versus autologous perforator flaps using the BREAST-Q.
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Matros E, Albornoz CR, Razdan SN, Mehrara BJ, Macadam SA, Ro T, McCarthy CM, Disa JJ, Cordeiro PG, and Pusic AL
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- Adult, Aged, Aged, 80 and over, Cost-Benefit Analysis, Decision Trees, Female, Humans, Middle Aged, Young Adult, Breast Implants economics, Breast Neoplasms economics, Breast Neoplasms surgery, Mammaplasty economics, Mammaplasty methods, Patient Satisfaction, Perforator Flap economics, Quality of Life
- Abstract
Background: Reimbursement has been recognized as a physician barrier to autologous reconstruction. Autologous reconstructions are more expensive than prosthetic reconstructions, but provide greater health-related quality of life. The authors' hypothesis is that autologous tissue reconstructions are cost-effective compared with prosthetic techniques when considering health-related quality of life and patient satisfaction., Methods: A cost-effectiveness analysis from the payer perspective, including patient input, was performed for unilateral and bilateral reconstructions with deep inferior epigastric perforator (DIEP) flaps and implants. The effectiveness measure was derived using the BREAST-Q and interpreted as the cost for obtaining 1 year of perfect breast health-related quality-adjusted life-year. Costs were obtained from the 2010 Nationwide Inpatient Sample. The incremental cost-effectiveness ratio was generated. A sensitivity analysis for age and stage at diagnosis was performed., Results: BREAST-Q scores from 309 patients with implants and 217 DIEP flap reconstructions were included. The additional cost for obtaining 1 year of perfect breast-related health for a unilateral DIEP flap compared with implant reconstruction was $11,941. For bilateral DIEP flaps compared with implant reconstructions, the cost for an additional breast health-related quality-adjusted life-year was $28,017. The sensitivity analysis demonstrated that the cost for an additional breast health-related quality-adjusted life-year for DIEP flaps compared with implants was less for younger patients and earlier stage breast cancer., Conclusions: DIEP flaps are cost-effective compared with implants, especially for unilateral reconstructions. Cost-effectiveness of autologous techniques is maximized in women with longer life expectancy. Patient-reported outcomes findings can be incorporated into cost-effectiveness analyses to demonstrate the relative value of reconstructive procedures.
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- 2015
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89. Development and assessment of Memorial Sloan Kettering Cancer Center's Surgical Secondary Events grading system.
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Strong VE, Selby LV, Sovel M, Disa JJ, Hoskins W, Dematteo R, Scardino P, and Jaques DP
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- Follow-Up Studies, Humans, Prognosis, Prospective Studies, Quality Improvement, Databases, Factual, Neoplasms surgery, Outcome Assessment, Health Care, Postoperative Complications, Secondary Prevention
- Abstract
Background: Studying surgical secondary events is an evolving effort with no current established system for database design, standard reporting, or definitions. Using the Clavien-Dindo classification as a guide, in 2001 we developed a Surgical Secondary Events database based on grade of event and required intervention to begin prospectively recording and analyzing all surgical secondary events (SSE)., Methods: Events are prospectively entered into the database by attending surgeons, house staff, and research staff. In 2008 we performed a blinded external audit of 1,498 operations that were randomly selected to examine the quality and reliability of the data., Results: Of 4,284 operations, 1,498 were audited during the third quarter of 2008. Of these operations, 79 % (N = 1,180) did not have a secondary event while 21 % (N = 318) had an identified event; 91 % of operations (1,365) were correctly entered into the SSE database. Also 97 % (129 of 133) of missed secondary events were grades I and II. There were 3 grade III (2 %) and 1 grade IV (1 %) secondary event that were missed. There were no missed grade 5 secondary events., Conclusions: Grade III-IV events are more accurately collected than grade I-II events. Robust and accurate secondary events data can be collected by clinicians and research staff, and these data can safely be used for quality improvement projects and research.
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- 2015
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90. Does the use of biopatch devices at drain sites reduce perioperative infectious complications in patients undergoing immediate tissue expander breast reconstruction?
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Weichman KE, Clavin NW, Miller HC, McCarthy CM, Pusic AL, Mehrara BJ, and Disa JJ
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- Breast Implants, Chlorhexidine administration & dosage, Drainage, Female, Humans, Middle Aged, Retrospective Studies, Time Factors, Anti-Infective Agents, Local administration & dosage, Bandages, Chlorhexidine analogs & derivatives, Mammaplasty methods, Surgical Wound Infection prevention & control, Tissue Expansion adverse effects
- Abstract
Background: To decrease the rate of infectious complications, surgeons have begun to use Biopatch (Ethicon, Somerville, N.J.) disks at drain exit sites. The authors investigated whether use of a Biopatch disk could convey a reduction in perioperative infections in patients undergoing immediate tissue expander breast reconstruction., Methods: A retrospective review was conducted of all patients undergoing tissue expander/implant breast reconstruction from November of 2010 to November of 2012 at a single institution. Breasts were divided into two cohorts: controls with traditional adhesive dressings and those with Biopatch disks at drain sites. Breasts were compared based on demographics, complications, drain duration, and antibiotic type., Results: A total of 1211 breasts met inclusion criteria. The control group (November of 2010 to October of 2011) included 606 breasts. The Biopatch cohort (November of 2011 to October of 2012) included 605 breasts. When comparing breasts with disks to controls, there were no statistical differences in overall infection (6.2 versus 7.4 percent; p = 0.4235), major infection (4.0 versus 4.3 percent; p = 0.8853), need for explantation (2.2 versus 1.8 percent; p = 0.5372), and mastectomy skin flap necrosis (12.6 versus 14.6 percent; p = 0.3148). However, age greater than 50 years, diabetes mellitus, hypertension, hypercholesterolemia, obesity, history of prior breast irradiation, and mastectomy skin flap necrosis were independent predictors of infectious complications., Conclusions: Biopatch disks do not reduce the rate infectious complications in patients undergoing immediate tissue expander breast reconstruction. Other conventional risks, including medical comorbidities, obesity, and mastectomy skin flap necrosis, remain significantly associated with infectious complications., Clinical Question/level of Evidence: Therapeutic, III.
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- 2015
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91. Important aspects of head and neck reconstruction.
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Hanasono MM, Matros E, and Disa JJ
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- Humans, Treatment Outcome, Head and Neck Neoplasms surgery, Oral Surgical Procedures methods, Plastic Surgery Procedures methods, Surgical Flaps
- Abstract
Learning Objectives: After studying this article, the participant should be able to: 1. Select appropriate local and pedicled flaps for oral cavity reconstruction based on the location and extent of the defect and donor-site characteristics. 2. Understand the functions of the tongue and select the appropriate reconstructive technique based on the size and location of the glossectomy defect. 3. Understand the advantages and disadvantages of treating various maxillectomy defects with prosthetics, soft-tissue pedicled and free flaps, and osteocutaneous free flaps. 4. Conceptualize a reconstructive algorithm for the hypopharynx based on the extent of circumference resected and need to replace external neck skin. 5. Understand advantages of the fibula over other osteocutaneous flaps for mandible reconstruction., Summary: Head and neck defects are among the most challenging for the reconstructive surgeon because of the intimate relationship between form and function in this anatomical area. Microsurgical techniques have improved outcomes for these procedures by expanding the available reconstructive methods beyond the limitations of traditional pedicled flaps, although the pectoralis flap remains a useful workhorse option. This article reviews current surgical techniques for reconstruction of the oral cavity, maxilla, hypopharynx, and mandible in the cancer patient.
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- 2014
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92. Diminishing relative contraindications for immediate breast reconstruction: a multicenter study.
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Albornoz CR, Cordeiro PG, Pusic AL, McCarthy CM, Mehrara BJ, Disa JJ, and Matros E
- Subjects
- Contraindications, Female, Follow-Up Studies, Humans, Mastectomy, Retrospective Studies, Risk Factors, Time Factors, United States epidemiology, Breast Implants trends, Breast Neoplasms surgery, Mammaplasty trends, Outcome and Process Assessment, Health Care, Postoperative Complications epidemiology, Risk Assessment methods
- Abstract
Background: During the past decade, there has been a rise in US breast reconstruction rates, with a greater expansion in prosthetic-based techniques relative to autologous transfer. Immediate reconstruction in high-risk oncologic and surgical patients might be a contributing factor to these trends., Study Design: The National Cancer Data Base from the American College of Surgeons and the American Cancer Society was used to identify a breast cancer cohort (1998 to 2011) treated with mastectomy. The patients were divided into high risk and low risk based on presence or absence of historic surgical or oncologic relative contraindications. Reconstructions were categorized as either autologous or implants. To understand trends for each high-risk characteristic, rates were adjusted by 1,000 total mastectomies performed for patients within each specific group and analyzed with Poisson regression., Results: Information from 1,040,088 patients with mastectomy was included. Rates of high-risk features did not change from 1998 to 2011. The increase in immediate reconstruction rates was greater for high-risk than low-risk patients (incidence rate ratio = 1.09 vs 1.06; p < 0.05 for both). There was a greater rate increase in implant than autologous reconstructions for both high-risk and low-risk groups. For high-risk patients, implant use increased for all features, but with the greatest change for elderly, comorbidities, and post-mastectomy radiotherapy (p < 0.01). For high-risk patients, autologous tissue use increased significantly for all features except pre-mastectomy radiotherapy., Conclusions: Breast reconstruction increased in high-risk surgical and oncologic patients, suggestive of a diminishing set of relative contraindications. Increased implant use in high-risk patients might be a contributing factor toward the preferential national expansion of prosthetic techniques., (Copyright © 2014 American College of Surgeons. Published by Elsevier Inc. All rights reserved.)
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- 2014
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93. Diminishing relative contraindications for immediate breast reconstruction.
- Author
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Albornoz CR, Cordeiro PG, Farias-Eisner G, Mehrara BJ, Pusic AL, McCarthy CM, Disa JJ, Hudis CA, and Matros E
- Subjects
- Adult, Age Factors, Aged, Breast Implants statistics & numerical data, Breast Implants trends, Contraindications, Diabetes Mellitus, Female, Humans, Mammaplasty instrumentation, Mammaplasty methods, Mastectomy, Middle Aged, New York City, Obesity, Poisson Distribution, Postoperative Complications epidemiology, Postoperative Complications etiology, Risk Factors, Smoking, Time Factors, Mammaplasty trends, Patient Selection
- Abstract
Background: The rise in U.S. immediate breast reconstruction over the past decade may reflect greater patient awareness or expanding use in women not previously offered reconstruction. The purpose of the current study was to determine whether reconstruction in high-risk surgical and oncologic patients was a factor contributing to increased reconstruction rates, specifically using prosthetic techniques., Methods: Information from a cohort of mastectomy patients from 2001 to 2012 was extracted from an institutional database, including the presence of high-risk surgical or oncologic features (age over 60 years old, body mass index greater than 30, comorbidities, smoking, advanced disease, and prior or postmastectomy radiotherapy). Trends in reconstruction rates and method were analyzed with Poisson regression. Reconstructive success was defined as tissue expander exchange to a permanent implant or autologous techniques without vascular complications., Results: A total of 10,299 patients were included. Immediate reconstruction in high-risk patients increased from 45.0 to 70.7 of 100 mastectomies (p < 0.01). Although autologous use increased only for obese patients (p < 0.01), prosthetic techniques were greater for all high-risk features (p < 0.01). Reconstructive success was 88 percent in high-risk patients; however, the number of failures was greater, including tissue expander loss, implant explantation, and flap vascular complications., Conclusions: The proportion of high-risk patients undergoing immediate breast reconstruction-specifically using prosthetic-based techniques-increased over the study period. Increased complications may be a tradeoff for the benefits of reconstruction. These findings support diminishing relative contraindications for immediate breast reconstruction at a tertiary cancer center., Clinical Question/level of Evidence: Risk, IV.
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- 2014
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94. Implant breast reconstruction and radiation: a multicenter analysis of long-term health-related quality of life and satisfaction.
- Author
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Albornoz CR, Matros E, McCarthy CM, Klassen A, Cano SJ, Alderman AK, VanLaeken N, Lennox P, Macadam SA, Disa JJ, Mehrara BJ, Cordeiro PG, and Pusic AL
- Subjects
- Breast Neoplasms radiotherapy, Breast Neoplasms surgery, Canada, Combined Modality Therapy, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasm Staging, Prognosis, Surveys and Questionnaires, Breast Implantation, Breast Neoplasms psychology, Mammaplasty psychology, Patient Satisfaction statistics & numerical data, Quality of Life
- Abstract
Background: Indications for radiotherapy in breast cancer treatment are expanding. Long-term satisfaction and health-related quality of life (HR-QOL), important outcomes after alloplastic breast reconstruction and radiation, have not been measured in irradiated patients by using a condition-specific, validated patient-reported outcomes instrument. The aim was to evaluate patient satisfaction and HR-QOL in patients with implant breast reconstruction and radiotherapy., Methods: A multicenter cross-sectional survey of patients who underwent implant-based breast reconstruction from three centers in the United States and Canada, with and without radiation, was performed. Satisfaction with breasts, satisfaction with outcome, psychosocial well-being, sexual well-being, and physical well-being outcomes were evaluated using the BREAST-Q(©) (Reconstruction Module). Multivariable analysis was performed to evaluate the effect of radiotherapy on patient satisfaction with breasts with adjustment by patient and treatment characteristics., Results: The response rate was 71 %, with 633 completed questionnaires returned. Mean follow-up was 3.3 years for irradiated patients (n = 219) and 3.7 years for nonirradiated patients (n = 414). Patients with radiation had significantly lower satisfaction with breasts (58.3 vs. 64.0; p < 0.01), satisfaction with outcome (66.8 vs. 71.4; p < 0.01), psychosocial well-being (66.7 vs. 70.9; p < 0.01), sexual well-being (47.0 vs. 52.3; p < 0.01), and physical well-being (71.8 vs. 75.1; p < 0.01) compared with nonirradiated patients. Multivariable analysis confirmed the negative effect of radiotherapy on satisfaction with breasts (β = -2.6; p = 0.03) when adjusted for patient and treatment factors., Conclusions: Radiotherapy has a negative effect on HR-QOL and satisfaction with breasts in patients with implant reconstruction compared with nonirradiated patients. The information provided here can inform decision-making and help set appropriate expectations for patients undergoing implant breast reconstruction and radiation.
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- 2014
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95. Bilateral implant reconstruction does not affect the quality of postmastectomy radiation therapy.
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Ho AY, Patel N, Ohri N, Morrow M, Mehrara BJ, Disa JJ, Cordeiro PG, Shi W, Zhang Z, Gelblum D, Nerbun CT, Woch KM, Ballangrud A, McCormick B, and Powell SN
- Subjects
- Adult, Aged, Aged, 80 and over, Combined Modality Therapy statistics & numerical data, Female, Humans, Incidence, Middle Aged, New York epidemiology, Radiation Injuries prevention & control, Radiotherapy, Adjuvant statistics & numerical data, Risk Factors, Treatment Outcome, Young Adult, Breast Implants statistics & numerical data, Breast Neoplasms epidemiology, Breast Neoplasms therapy, Mastectomy statistics & numerical data, Radiation Injuries epidemiology, Radiotherapy, Conformal statistics & numerical data
- Abstract
To determine if the presence of bilateral implants, in addition to other anatomic and treatment-related variables, affects coverage of the target volume and dose to the heart and lung in patients receiving postmastectomy radiation therapy (PMRT). A total of 197 consecutive women with breast cancer underwent mastectomy and immediate tissue expander (TE) placement, with or without exchange for a permanent implant (PI) before radiation therapy at our center. PMRT was delivered with 2 tangential beams + supraclavicular lymph node field (50Gy). Patients were grouped by implant number: 51% unilateral (100) and 49% bilateral (97). The planning target volume (PTV) (defined as implant + chest wall + nodes), heart, and ipsilateral lung were contoured and the following parameters were abstracted from dose-volume histogram (DVH) data: PTV D95% > 98%, Lung V20Gy > 30%, and Heart V25Gy > 5%. Univariate (UVA) and multivariate analyses (MVA) were performed to determine the association of variables with these parameters. The 2 groups were well balanced for implant type and volume, internal mammary node (IMN) treatment, and laterality. In the entire cohort, 90% had PTV D95% > 98%, indicating excellent coverage of the chest wall. Of the patients, 27% had high lung doses (V20Gy > 30%) and 16% had high heart doses (V25Gy > 5%). No significant factors were associated with suboptimal PTV coverage. On MVA, IMN treatment was found to be highly associated with high lung and heart doses (both p < 0.0001), but implant number was not (p = 0.54). In patients with bilateral implants, IMN treatment was the only predictor of dose to the contralateral implant (p = 0.001). In conclusion, bilateral implants do not compromise coverage of the target volume or increase lung and heart dose in patients receiving PMRT. The most important predictor of high lung and heart doses in patients with implant-based reconstruction, whether unilateral or bilateral, is treatment of the IMNs. Refinement of radiation techniques in reconstructed patients who require comprehensive nodal irradiation is warranted., (Copyright © 2014 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
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96. Economic implications of recent trends in U.S. immediate autologous breast reconstruction.
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Albornoz CR, Cordeiro PG, Mehrara BJ, Pusic AL, McCarthy CM, Disa JJ, and Matros E
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- Female, Hospital Charges statistics & numerical data, Hospitals statistics & numerical data, Humans, Mammaplasty statistics & numerical data, Mastectomy, Microsurgery, United States epidemiology, Breast Neoplasms surgery, Mammaplasty economics, Mammaplasty trends
- Abstract
Background: Recent trends in U.S. breast oncology and autologous reconstruction, such as greater use of contralateral prophylactic mastectomies and microsurgery, may have increased reconstructive complication rates and costs. Simultaneously, with the increased complexity of autologous reconstruction in the setting of declining reimbursement, there may be market concentration of these procedures to specialized high-volume centers. This study aimed to (1) measure cost of autologous reconstruction in the setting of microsurgical technique, contralateral prophylactic mastectomies, and high-volume centers; and (2) analyze trends in market share of these procedures., Methods: Inflation-adjusted hospital charges were analyzed for autologous procedures using the Nationwide Inpatient Sample database (1998 to 2010), including a subgroup of microsurgical cases. Median charges were adjusted by patient case mix and analyzed by outcome, procedure type, and hospital volume using the Mann-Whitney test. Market share was evaluated through examination of trends in hospitals performing autologous reconstruction and procedures at high-volume centers., Results: Median charges for 21,016 autologous reconstructions were $22,198. Costs were higher for bilateral reconstruction ($34,202) and microsurgical cases ($57,449). Hospital charges increased from $20,315 (no complications) to $42,210 when both surgery-specific and systemic complications were present (p < 0.01). High-volume hospitals reduced charges by 7.5 percent and had lower costs in the setting of complications (p < 0.01). The number of hospitals performing autologous reconstructions decreased 35 percent, with increasing annual procedures in high-volume centers (48.3 to 73.3, p < 0.01)., Conclusions: Bilateral reconstructions and microsurgical technique are associated with greater health care costs. The market concentration of autologous reconstruction to high-volume centers is associated with reduced charges. The long-term implications of this trend are unknown.
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- 2014
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97. Abstract 45: broadening indications for immediate implant-based breast reconstruction.
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Albornoz CR, Farias-Eisner G, Disa JJ, Mehrara BJ, McCarthy CM, Pusic AL, Cordeiro PG, and Matros E
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- 2014
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98. Chest and upper body morbidity following immediate postmastectomy breast reconstruction.
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McCarthy CM, Mehrara BJ, Long T, Garcia P, Kropf N, Klassen AF, Cano SJ, Li Y, Hurley K, Scott A, Disa JJ, Cordeiro PG, and Pusic AL
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Carcinoma, Intraductal, Noninfiltrating surgery, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Middle Aged, Morbidity, Muscle Weakness physiopathology, Prognosis, Quality of Life, Range of Motion, Articular, Surgical Flaps, Surveys and Questionnaires, Tissue Expansion Devices, Breast Neoplasms surgery, Mammaplasty adverse effects, Mastectomy adverse effects, Muscle Weakness etiology, Postoperative Complications, Thoracic Wall pathology
- Abstract
Objective: The performance of a mastectomy for the treatment or prophylaxis of breast cancer may have long-term implications for both physical and mental well-being in women. The development of breast numbness and phantom breast sensations following mastectomy is well-known; however, relatively little is known about physical morbidity following postmastectomy breast reconstruction. The primary objective of this study was to evaluate the level of physical morbidity experienced following three surgical approaches: mastectomy alone, postmastectomy tissue expander/implant reconstruction, and postmastectomy autogenous tissue reconstruction., Methods: We conducted a cross-sectional survey of a sample of women who had undergone mastectomy with or without reconstruction. Chest and upper body morbidity were evaluated using the BREAST-Q. Physical well-being was compared across three types of breast surgery., Results: In total, 308 of 452 women who received a questionnaire booklet returned completed questionnaires. There was an overall difference in physical morbidity attributable to surgical treatment (P < 0.001). Patients who underwent autogenous tissue reconstruction had the highest (i.e., best) mean physical well-being score. Women who underwent expander/implant reconstruction also had less chronic physical morbidity than women who underwent mastectomy alone (P < 0.05)., Conclusions: Our findings suggest that women who undergo immediate autogenous tissue reconstruction experience significantly less chest and upper body morbidity than those who undergo either mastectomy with implant-based reconstruction or mastectomy alone. This information can be used to facilitate clinical decision-making, to validate individual experiences of breast cancer survivors, and to inform future innovations to decrease the long-term physical morbidity associated with breast cancer surgery.
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- 2014
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99. Bilateral implant breast reconstruction: outcomes, predictors, and matched cohort analysis in 730 2-stage breast reconstructions over 10 years.
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Antony AK, McCarthy C, Disa JJ, and Mehrara BJ
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- Adult, Aged, Female, Humans, Implant Capsular Contracture epidemiology, Logistic Models, Matched-Pair Analysis, Middle Aged, Retrospective Studies, Risk Factors, Tissue Expansion, Treatment Outcome, Breast Implantation methods, Breast Neoplasms surgery
- Abstract
Background: Rates of bilateral implant breast reconstruction (BI/BR) are rising despite the lack of precise information. Previous studies have examined unilateral reconstruction, making it difficult to counsel patients regarding the risk of BI/BR. The purpose of this study was to identify the incidence of complications and predictors of unfavorable aesthetic outcomes in the largest study to date of exclusive 2-stage BI/BR. Furthermore, a novel matched cohort analysis was conducted in patients who underwent contralateral prophylactic mastectomy and therapeutic mastectomy, whereby each patient acts as her own perfect internal control., Methods: A retrospective chart review of consecutive patients who underwent BI/BR from 1997 to 2007 was performed to obtain patient demographics, treatment, and outcomes. Univariate and multivariate logistic regression analyses were performed to determine risk factors leading to the development of unfavorable aesthetic outcomes. χ test and Fisher exact analysis were used for matched-pairs analysis., Results: Seven hundred thirty 2-stage BI/BRs were performed in 365 patients; perioperative complication rates were low at 9.3%. Long-term outcomes/unfavorable aesthetics were rippling (12.7%), capsular contracture (8.4%), and malposition (7.8%). After regression analysis, age [odds ratio (OR), 1.05], radiation (OR, 4.27), and length of follow-up (OR, 1.48) were significantly associated with capsular contracture. Radiation (OR, 0.26) and body mass index (OR, 0.95) were inversely associated with rippling. In the matched cohort, complication rates were similar between sides with malposition and rippling as significantly different aesthetic outcomes (P < 0.05). Adjusted individual complication rates in the bilateral cohort of 18.4% were comparable with previous mixed and majority unilateral cohorts in the literature., Conclusions: Bilateral implant breast reconstruction has become increasingly prevalent for patients with breast cancer. Overall complications are low; BI/BR does not appear to incur additive risk. Matched cohort analysis confirmed low complication rates with only malposition and rippling as significant differences between sides.
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- 2014
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100. Discussion: percutaneous aponeurotomy and lipofilling: a regenerative alternative to flap reconstruction?
- Author
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Matros E and Disa JJ
- Subjects
- Female, Humans, Male, Adipose Tissue transplantation, Cicatrix surgery, Fasciotomy, Guided Tissue Regeneration methods, Wounds and Injuries surgery
- Published
- 2013
- Full Text
- View/download PDF
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