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Digital game-based learning is gradually becoming a trend in education, with certain positive impacts. Thanks to the game element, children's learning process becomes easier and more enjoyable. This study surveyed over 100 preschool teachers in Hue city, Thua Thien Hue province, to clarify the importance of applying technology software in designing educational games. Consequently, the process of designing and using educational games to help children become familiar with Math symbols is proposed based on Wordwall software. The proposed process received strong agreement from preschool teachers. To use Wordwall software-based games effectively in math familiarization activities, teachers need to be flexible and proactive in selecting games that are appropriate for the lesson’s objectives and content as well as the characteristics of preschool children. This study serves as a useful tool to support preschool teachers in designing educational games in general and educational games for familiarizing children with mathematical symbols in particular.

River basins receive wastewater from socio-economic activities. In such a context, a comprehensive assessment and forecast of load-bearing capacity needs to be developed. This capacity depends on many complex factors, such as hydrology, hydraulics, and environment, leading to applying a modelling approach. This study aims to propose a hybrid modelling approach to evaluate and predict the river water environmental capacity (RWEC) in a basin. Big data technology with Python is applied to process modelling results and RWEC forecasts. The long short-term memory (LSTM) model predicts RWEC on each reach of the river channel network. The {RWECP, i, P = Nitrate, BOD, Phosphate, i = hourly} data set and related factors form a time series of data used for the LSTM forecasting model. Forecast results are evaluated through the root mean square error (RMSE) and mean absolute error (MAE). The results show that the average level over all 24 reaches for 7 forecast days: RMSENitrate = 22.16 (kg/day), RMSEBOD = 38.92 (kg/day), and RMSEPhosphate = 0.79 (kg/day). This is an acceptable result for a complex system and 7-day forecast. The results of the study help significantly with pollution control. HIGHLIGHTS Suggesting steps to determine river water environmental capacity (RWEC).; Building a forecasting model based on long short-term memory (LSTM) to predict RWEC.; Assessing and forecasting RWEC for the concrete basin.; Comparing forecast accuracy by standard metric RMSE and MAE.; Clarifying RWEC dependence on hydrodynamic and environmental factors.;

A TiO2/graphene quantum dots composite (TiO2/GQDs) obtained by in situ synthesis of GQDs, derived from coffee grounds, and peroxo titanium complexes was used as electrode modifier in the simultaneous electrochemical determination of uric acid and hypoxanthine. The TiO2/GQDs material was characterized by photoluminescence, X-ray diffraction, Raman spectroscopy, high-resolution transmission electron microscopy, and energy-dispersive X-ray mapping. The TiO2/GQDs-GCE exhibits better electrochemical activity for uric acid and hypoxanthine than GQDs/GCE or TiO2/GCE in differential pulse voltammetry (DPV) measurements. Under optimized conditions, the calibration plots were linear in the range from 1.00 to 15.26 μM for both uric acid and hypoxanthine. The limits of detection of this method were 0.58 and 0.68 μM for uric acid and hypoxanthine, respectively. The proposed DPV method was employed to determine uric acid and hypoxanthine in urine samples with acceptable recovery rates.

Vancomycin is a critical antibiotic frequently utilized in clinical settings, with therapeutic drug monitoring (TDM) strongly advised to optimize treatment efficacy and mitigate the risk of adverse effects. However, current methods for measuring vancomycin levels in human plasma are hindered by long analysis times and complicated sample preparations. Thus, this study developed and validated a novel UPLC-MS/MS method for a rapid (with a running time of 3.5 min) and simple analysis of plasma vancomycin. To quantify vancomycin concentration in human plasma, we have developed and validated the UPLC-MS/MS method with high sensitivity, specificity, and accuracy, meeting the strict criteria according to the Food and Drugs Administration (FDA) guidelines for validation biological analysis methods. Vancomycin and atenolol (internal standard) underwent positive electrospray ionization (ESI+) and detection in multi-reaction monitoring (MRM) mode. The selected MRM transitions were m/z 725.66→144.16 for vancomycin and m/z 267.29→189.96 for atenolol. Plasma samples were precipitated using a simple mixture containing acetonitrile, methanol, and formic acid as a pH adjuster. The separation was performed using the Poroshell 120 Phenyl Hexyl Column (4.6 × 150 mm, 2.7 μm) maintained at 25 °C for 3.5 min. Isocratic elution with a mobile phase (methanol and 0.1% formic acid in a 40:60 v/v ratio) at a flow rate of 0.5 mL/min was employed. The method showed linearity (0.1–75 μg/mL) with a coefficient of determination above 0.9994 and a lower limit of quantification at 0.1 μg/mL. Precision, both intraday and interday, was below 10%, and accuracy ranged from 91.70% to 111.57%. System suitability, selectivity, stability, carryover, dilution, recovery, and matrix effect validation results all met acceptable criteria. The established UPLC-MS/MS method is expected to be a rapid, simple, and reliable tool for drug monitoring and pharmacokinetic studies, enhancing patient care during vancomycin administration.

Abstract Background With approximately 500 people affected in Austria, epidermolysis bullosa (EB) is a rare genetic skin disease reducing the quality of life of those affected and their relatives. The intensive efforts of the patient organisation DEBRA Austria during the last decades have led to a unique situation of those affected and their relatives, with increased support and broader knowledge about the disease in the general population. The aim of the study is to evaluate the current situation of patients and their relatives living in Austria, with a focus on burdens and helpful practices. Results The mixed-methods study consisted of two parts: a qualitative interview study to identify psychosocial aspects of EB in those affected and their relatives, and a subsequent online survey to further assess those aspects in a larger sample, resulting in a total of n=78 Austrian participants. The impact of EB on the quality of life of EB patients and their relatives in Austria is related to the current health status, psychological burden, mobility, visibility, financial situation as well as job prospects. Personal and social resources and external support have a significant influence on the individual situation. Conclusions The outcome is mapped to concrete implications regarding targeted support for EB patients and their relatives on an individual level and their needs in regard to the Austrian health care system.

Abstract Background Hepatitis B virus (HBV) vaccination in Vietnamese adults remains low and unequally distributed. We conducted a study on HBV-naïve adults living in Ho Chi Minh City, Viet Nam, to determine barriers associated with HBV vaccination uptake after removing the financial barrier by providing free coupons for HBV vaccination. Methods After being screened for HBsAg, anti-HBs, and anti-HBc, 284 HBV-naïve study participants aged 18 and over (i.e., negative for HBsAg, anti-HBs, and anti-HBc total) were provided free 3-dose HBV vaccine coupons. Next, study participants’ receipt of 1st, 2nd, and 3rd doses of HBV vaccine was documented at a pre-specified study healthcare facility, where HBV vaccines were distributed at no cost to the participants. Upon study entry, participants answered questionnaires on sociodemographics, knowledge of HBV and HBV vaccination, and related social and behavioral factors. The proportions of three doses of HBV vaccine uptake and their confidence intervals were analyzed. Associations of HBV vaccine initiation with exposures at study entry were evaluated using modified Poisson regression. Results 98.9% (281 of 284) of study participants had complete data and were included in the analysis. The proportion of participants obtaining the 1st, 2nd, and 3rd doses of HBV vaccine was 11.7% (95% Confidence Interval [95% CI] 8.0-15.5%), 10.7% (95%CI 7.1–14.3%), and 8.9% (95%CI 5.6–12.2%), respectively. On the other hand, participants were more likely to initiate the 1st dose if they had adequate knowledge of transmission (adjusted relative risk [aRR] = 2.58, 95% CI 1.12–5.92), adequate knowledge of severity (aRR = 6.75, 95%CI 3.38–13.48), and annual health-checking seeking behavior (aRR = 2.04, 95%CI 1.07–3.87). Conclusion We documented a low HBV vaccination uptake despite incentivization. However, increased vaccine initiation was associated with better HBV knowledge and annual health check-up adherence. When considering expanding HBV vaccination to the general adult population, we should appreciate that HBV knowledge is an independent predictor of vaccine uptake.

The outbreak of COVID-19 pandemic since the last days of 2019 has led to school closure worldwide and forced institutions at all levels to move to online or distance learning. This study was conducted to explore university students' readiness to such a sudden situational shift to online learning. We surveyed 1304 online-learning students in a higher education institution in Vietnam. Through exploratory factor analyses, we identified three dimensions of online learning readiness (OLR): online learning motivation, online learning self-efficacy beliefs, and online self-directed learning. We then conducted multiple regression analyses to investigate the predictive power of different students' individual characteristics and perceptions on OLR, and the impacts of the three OLR dimensions on students' intention to use online learning (IU). Our results suggested that students' perceived facilitating conditions and their online learning experience were the significant predictors of OLR. Furthermore, online learning motivation was the construct that exerted the strongest influence on IU, compared to other OLR constructs. The study highlights the need for improving facilitating conditions to support students' OLR. It also suggests enhancing the usefulness and enjoyment that students perceive from online learning to improve their willingness to use this learning channel.

Purpose: For culturally responsive practices (CRPs) in schools to be successful, educational leaders must look outside of the school and consider school, district, and system-level policies and practices that influence the sustainability of culturally responsive classrooms. The purpose of our study was to conduct a comparative case study and explore how four district leaders promoted CRPs throughout each of their districts. Research Design: Situated in the Midwest, we used a comparative case study to explore the approaches of four Black women school district leaders. Data included a focus group interview with the leaders; four individual, follow-up interviews; and artifacts or documents provided by the leaders. The data collected was analyzed using the Culturally Responsive School Leadership analytical framework. Results and Discussion: Findings discuss school district leadership's responsibility to promote CRPs; district leaders' ability to foster trusting relationships with educators; and district-wide efforts to engage in purposeful teacher retention practices. A discussion and conclusion include implications considering how district leadership can influence the implementation of CRPs in schools and classrooms.

INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College of Gastroenterology, aims to inform clinicians and patients by providing evidence-based practice recommendations for the pharmacological treatment of CIC in adults. METHODS: The American Gastroenterological Association and the American College of Gastroenterology formed a multidisciplinary guideline panel that conducted systematic reviews of the following agents: fiber, osmotic laxatives (polyethylene glycol, magnesium oxide, lactulose), stimulant laxatives (bisacodyl, sodium picosulfate, senna), secretagogues (lubiprostone, linaclotide, plecanatide), and serotonin type 4 agonist (prucalopride). The panel prioritized clinical questions and outcomes and used the Grading of Recommendations Assessment, Development, and Evaluation framework to assess the certainty of evidence for each intervention. The Evidence to Decision framework was used to develop clinical recommendations based on the balance between the desirable and undesirable effects, patient values, costs, and health equity considerations. RESULTS: The panel agreed on 10 recommendations for the pharmacological management of CIC in adults. Based on available evidence, the panel made strong recommendations for the use of polyethylene glycol, sodium picosulfate, linaclotide, plecanatide, and prucalopride for CIC in adults. Conditional recommendations were made for the use of fiber, lactulose, senna, magnesium oxide, and lubiprostone. DISCUSSION: This document provides a comprehensive outline of the various over-the-counter and prescription pharmacological agents available for the treatment of CIC. The guidelines are meant to provide a framework for approaching the management of CIC; clinical providers should engage in shared decision making based on patient preferences as well as medication cost and availability. Limitations and gaps in the evidence are highlighted to help guide future research opportunities and enhance the care of patients with chronic constipation.

Although antiracism activism has contributed to substantive progress under certain circumstances and in certain contexts, little research attempts to theorize how antiracism activism is manifest across contexts. In this article, we explore individual and collective antiracist actions within and outside schools. We introduce a theoretical framework that identifies four domains of activism--policy, community, leadership, and teaching and learning--in which activists operate to make a positive difference in promoting racial equity and antiracism in education. The framework offers a systemic way of thinking about antiracist activism in education and the importance of recognizing that several aspects of antiracist activism usually conceived as distinct are interrelated within and across domains. Indeed, antiracist education activism must be understood holistically and systemically if we seek to dismantle the racism that is woven into every piece of the education system.

This study investigates the difficulties in translation and factors influencing the translating process from foreign language students' perspectives at a private university. This work also aims to find out the reasons why foreign language students encounter the difficulties in the process and learn about the different ways in which students majoring in English translate a text into their first language of Vietnamese. Using the mixed method (quantitative and qualitative), the study analysis is based on descriptive statistics using SPSS programme and individual interview results. The results showed that salient findings emerged from the data concerning the relationships between four factors namely "lexis," "grammar," "culture," and "existing knowledge" under student's viewpoints. Those elements affected students hierarchically in their process of translation, in which lexis was the most difficult factor while grammar seemed to be less remarkable. Therefore, based on the findings, it is suggested to adjust, modify, and select appropriate translation materials in the curricula in higher education to well equip students with those elements to compete in the translation industry.

"EFL Teachers' Perceptions of the Individualized Learning (IL) Model: A Case at an English Language Center" was conducted to obtain two research aims: (1) to find out the teachers' perceptions of the IL model; (2) to investigate the benefits and difficulties teachers face when they implement the IL model in their classrooms. The research utilized the questionnaire and semi-structured interview to collect data from 26 teachers from the English language center where the individualized learning model is implemented. The results show that the mean scores of all items related to teachers' perceptions show that their perceptions of the IL were high (M=3.8423) on the five-point Likert scale (see Table 2). As a result, the teacher understood the IL rather well and revealed four main advantages related to the flexibility of the learning pace, the material and the learning schedule; the instant supports from the teachers; the increase in learners' confidence; and the improvement of learners' academic performance. However, the results of the interview also revealed two main disadvantages including time-consuming and lack of interaction between learners and learners. In addition, the results also show that there was a positive correlation between teachers' perceptions and the way they implemented the IL in their classroom. The contention is that decision should be made as to what degree of the individualization will be implemented.

From the leaves of Rubus annamensis Cardot collected in Lam Dong Province, two triterpene compounds were isolated and identified as niga-ichigoside F1 (2α,3β,19α,23-tetrahydroxy-urs-12-en-28-oic acid-β-D-glucopyranosyl ester) and ursolic acid (3-beta-3-hydroxy-urs-12-ene-28-oic acid) by using chromatographic and spectroscopic methods (IR, 1H-NMR, 13C-NMR, DEPT, HSQC, HMBC, and ESI-MS). This is the first time these compounds have been isolated from Rubus annamensis.

This is one part of the 4-H Volunteer Training series. It was originally written in 2005, adapted in 2014, and updated in 2023.

This is one part of the 4-H Volunteer Training series. It was originally published in 2005 and revised in 2012. It was updated in the summer of 2023 and is now published in 2024.

Introduction Reduced thrombin generation is an important component of post cardiopulmonary bypass (CPB) coagulopathy. To replenish coagulation factors and enhance thrombin generation in bleeding surgical patients, frozen plasma (FP) and four-factor prothrombin complex concentrate (4F-PCC) are used. However, the efficacy–safety balance of 4F-PCC relative to FP in cardiac surgery is unconfirmed.Methods and analysis LEX-211 (FARES-II) is an active-control, randomised, phase 3 study comparing two coagulation factor replacement therapies in bleeding adult cardiac surgical patients at 12 hospitals in Canada and the USA. The primary objective is to determine whether 4F-PCC (Octaplex/Balfaxar, Octapharma) is clinically non-inferior to FP for haemostatic effectiveness. Inclusion criteria are any index (elective or non-elective) cardiac surgery employing CPB and coagulation factor replacement with 4F-PCC or FP ordered in the operating room for bleeding management. Patients will be randomised to receive 1500 or 2000 international units of 4F-PCC or 3 or 4 units of FP, depending on body weight. The primary endpoint of haemostatic treatment response is ‘effective’ if no additional haemostatic intervention is required from 60 min to 24 hours after the first initiation of 4F-PCC or FP; or ‘ineffective’ if any other haemostatic intervention (including a second dose of study drug) is required. An estimated 410 evaluable patients will be required to demonstrate non-inferiority (one-sided α of 0.025, power ≥90%, non-inferiority margin 0.10). Secondary outcomes include transfusions, bleeding-related clinical endpoints, coagulation parameters and safety.Ethics and dissemination The trial has been approved by the institutional review boards of all participating centres. Trial completion is anticipated at the end of 2024, and results will be disseminated via publications in peer-reviewed journals and conference presentations in 2025. The results will advance our understanding of coagulation management in bleeding surgical patients, potentially reducing the need for allogeneic blood products and improving outcomes in surgical patients.Trial registration number NCT05523297.