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A technique has been developed to analyse the free-space acoustic signature of the Rolls-Royce Merlin engine in order to provide diagnostic information relating to its performance. The work is motivated by a need to maintain the reliability and maximise the lifetime of this historic engine which is an important component of the aircraft operated by the UK Battle of Britain Memorial Flight (BBMF). For convenience, the data were extracted from the soundtrack of a video recording made whilst the aircraft was undergoing a full-power ground-run. The aim of the work is to generate information relating the individual firings of each cylinder and this is presented as a multi-level colour image. Here, the ignition time history for two revolutions (six ignitions) is shown vertically and corresponds to the bank of exhaust ports facing the microphone. Subsequent similar histories are presented along the horizontal time axis. The results are sensitive to engine speed variations, and a correlation between successive vertical columns is carried out to quantify this drift and adjust the data accordingly. Seven engine speeds from 842 to 2740 rpm are examined. The processed data illustrate that some speeds exhibit well-defined, single ignitions whereas others show varying degrees of after-firing type effects. At the higher engine speeds, it would seem that the cylinder ignition amplitudes become much more irregular, and the results for 2740 rpm indicate a breakdown in engine performance. The coefficient of variation (Cv) has been demonstrated as a measure of these factors. Finally, a technique has been proposed and demonstrated for the identification of individual cylinders in the firing sequence. The data acquisition process is relatively straight-forward and should not demand excessive time to cover a full range of engine speeds. With further investigations, it could be possible to readily relate the imaging results to specific engine faults.

Biological dosimetry is the measurement of radiation-induced changes in the human to measure short and long-term health risks. Biodosimetry offers an independent means of obtaining dose information and also provides diagnostic information on the potential for “partial-body” exposure information using biological indicators and otherwise based on computer modeling, dose reconstruction, and physical dosimetry. A variety of biodosimetry tools are available and some features make some more valuable than others. Among the available biodosimetry tool, cytogenetic biodosimetry methods occupy an exclusive and advantageous position. The cytogenetic analysis can complement physical dosimetry by confirming or ruling out an accidental radiological exposure or overexposures. We are discussing the recent developments and adaptability of currently available cytogenetic biological dosimetry assays.

Background The objective of this study was to evaluate the diagnostic value of intraoperative frozen section analysis (IFSA) of tumor bed margins in patients with oral squamous cell carcinoma (OSCC). Methods This retrospective study includes 194 primary OSCC cases. The impact of intraoperative information by IFSA on final margin status, local recurrence, and disease-specific survival were analyzed. Results IFSA revealed a 50% sensitivity and a 100% specificity, with a positive and negative predictive value of 100% and 89.1%, respectively. In 19 cases, margins were rated positive by IFSA and remained positive in eight cases (42.1%), despite immediate re-resection. This constellation led to higher recurrence and lower survival rates than in cases with consecutive R0 status (each p = 0.046). Positive margins in IFSA were associated with closer final margins (p = 0.022) and early recurrences (p = 0.050). Conclusions Achieving instant R0 status has a crucial impact on disease recurrence and patient survival. IFSA falls short to ensure secure definite surgical margins. Thus, improved intraoperative diagnostic information on the location and extent of OSCC could support patient treatment. Clinical relevance Considering that patient survival has not improved despite progress in surgical and adjuvant therapy, the process and outcome of IFSA was scrutinized as one part of the treatment concept.

New approaches to the analysis of Morlet wavelet spectra of electroencephalograms, electromyograms, and accelerometer signals are proposed. The proposed approaches are based on the analysis of time−frequency distributions of local extrema and ridges of wavelet spectrograms. The paper describes the results of application of the proposed techniques for the diagnosis of the early stage of Parkinson’s disease and essential tremor, monitoring of postoperative patients with epilepsy, and assessment of inter-channel phase coupling of EEG during cognitive tests of patients after traumatic brain injury.

We sometimes learn about certain behaviors of others that we consider diagnostic of their character (e.g., that they did immoral things). Recent research has shown that such information trumps the impact of other (less diagnostic) information both on self-reported evaluations and on more automatic evaluations as probed with indirect measures such as the Affect Misattribution Procedure (AMP). We examined whether facilitating memory recall of alternative information moderates the impact of diagnostic information on evaluation. In Experiments 1 and 2, participants learned one diagnostic positive and one diagnostic negative behavior of two unfamiliar people. Presenting a cue semantically related to this information during evaluation influenced AMP scores but not self-reported liking scores. Experiments 3 and 4 showed that elaborative rehearsal of low diagnostic information eliminated diagnosticity effects on AMP scores and reduced them on self-reported liking scores. These findings help elucidate the role of memory recall and diagnosticity in evaluation.

Background Bronchoalveolar lavage (BAL) is a technique classically used for the study of diffuse interstitial lung diseases (DILDs). Given the recent advances in the diagnosis of DILD by transbronchial cryobiopsy (TBCB), it is relevant to assess what BAL can contribute to TBCB. Patients and methods This is a retrospective descriptive study that included patients with DILD who, between 2013 and 2017, underwent BAL and TBCB in the same bronchoscopy intervention. We evaluated the complementary information provided by BAL to TBCB that facilitated the diagnosis by a multidisciplinary committee. Epidemiological, clinical, and functional variables and high-resolution chest tomography findings were recorded, along with complications associated with the procedures. Results A total of 60 patients were included. TBCB, conditioned by the underlying radiologic pattern, provided diagnostic information in 75% of cases. BAL provided complementary information that supported the diagnosis and treatment in 22% of cases. Differential BAL findings were related to microbiology, cell count, and immunology. Regarding the safety of the procedure, 47% of the patients experienced complications, although none were serious. Conclusion BAL findings contribute to TBCB findings in the diagnosis of DILDs, with no serious complications associated with their combined use.

To ensure the quality assurance of CT-examinations, it is necessary to obtain the high-quality diagnostic information and maintain the optimal exposure levels of patients and medical staff. This paper is focused on the requirements and main aspects of quality assurance of CT-examinations, which include quality control of the equipment, methods of CT-image quality control, optimization of radiation protection, as well as management of the unintended and accidental medical exposure. The paper contains recommendations on quality control of diagnostic equipment, methods for monitoring the quality control of CT-images, values of diagnostic reference levels for the detection of abnormally high patient doses and optimization of the radiation protection of patients, as well as the recommendations for management of radiation and non-radiation accidents. All main sections of the paper represent an unified quality assurance system in computed tomography.

18F-Sodium fluoride (NaF) is primarily a skeletal imaging agent which can be localized in extraosseous calcified foci. Here, we describe a case of a 48-year-old man with bladder carcinoma referred for staging using 18F-NaF positron emission tomography/computed tomography (PET/CT). 18F-NaF PET/CT detected a calcified soft tissue mass in the urinary bladder. Extraosseous 18F-NaF uptake is often encountered and these non-osseous findings could possibly provide important diagnostic information. Thus, recognition of extraosseous 18F-NaF activity has implications for accurate staging and management.

OBJECTIVE: In this study, we present an appropriate angle of incidence to reduce the distortions in images of L4 and L5 during a general anteroposterior radiograph examination. METHOD: We selected 170 patients who had normal radiological findings among those who underwent anteroposterior and lateral examination for lumbar vertebrae. An optimum angle of incidence wa suggested through the statistical analysis by measuring the lumbar lordosis angle and the intervertebral disc angle in these 170 patients. RESULT: We suggested the incident angle (10.28°) of L4 and the incident angle (23.49°) of L5. We compared the distorted area ratios when the incident angle was 0°, 10°, and 23.5° using the ATOM® phantom. The ratio for the L4 decreased from 14.90% to 12.11% and that of the L5 decreased from 15.25% to 13.72% after applying the angle of incidence. We determined the incident angle (9.34°) of L4 and (21.26°) of L5 below 30° of LLA. Thus, we determined the incident angle (11.21°) of L4 and (25.73°) of L5 above 30° of LLA. CONCLUSION: When you apply the optimum angle of incidence, the distortion of image was minimized and an image between the joints adjacent to the anteroposterior vertebral image with an accurate structure was obtained. As a result, we were able to improve the quality of the image and enhance diagnostic information.

Jiang, Hoegg, Dahl, and Chattopadhyay (2009) demonstrated that customers prefer a service provider who shares incidental similarity, such as having the same birthday. However, customers often choose from multiple service providers simultaneously. It is unclear which specific shared characteristics will influence choice in any given buying situation. Although all similarity may lead to a personal connection, goal-relevant similarity also provides diagnostic information that is related to customer buying goals while incidental similarity does not. This research consists of four experimental studies that demonstrate specific benefits and limitations of incidental similarity. When there are multiple service providers, customers will prefer providers with goal-relevant similarity over incidental similarity. However, when customers share goal-relevant similarity with multiple providers, customers then use incidental similarity to further narrow down their choice. Finally, characteristics are not inherently “goal-relevant” or “incidental,” but rather vary based on customer buying need and situational factors.

Purpose: In Canada, ultrasonography is the primary imaging modality for children with suspected appendicitis, yet equivocal studies are common. Magnetic resonance imaging provides promise as an adjunct imaging strategy. The primary objective of this study was to determine the proportion of children with suspected appendicitis and equivocal ultrasound where magnetic resonance imaging determined a diagnosis. Methods: A prospective consecutive cohort of children aged 5-17 years presenting to a tertiary pediatric Emergency Department with suspected appendicitis were enrolled. Participants underwent diagnostic and management strategies according to our local suspected appendicitis pathway, followed by magnetic resonance (Siemens Avanto 1.5 Tesla) imaging. Sub-specialty pediatric radiologists reported all images. Results: Magnetic resonance imaging was performed in 101 children with suspected appendicitis. The mean age was 11.9 (SD 3.4) years and median Pediatric Appendicitis Score was 6 [IQR 4,8]. Ultrasonography was completed in 98/101 (97.0%). Of 53/98 (54.1%) with equivocal ultrasound, magnetic resonance imaging provided further diagnostic information in 41 (77.4%; 10 positive, 31 negative; 12 remained equivocal). Secondary findings of appendicitis on magnetic resonance imaging in children with equivocal ultrasound included abdominal free fluid (24, 45.3%), peri-appendiceal fluid (12, 22.6%), intraluminal appendiceal fluid (9, 17.0%), fat stranding (8, 15.1%), appendicolith (2, 3.8%), and peri-appendiceal abscess (1, 1.9%). The observed agreement between magnetic resonance imaging results and final diagnosis was 94.9% (kappa = 0.89).

Summary Context Faced with the failures he encountered in the treatment of chronic diseases, using only the principle of similarity, Samuel Hahnemann gradually developed a more global approach to the patient. He identified three miasms, nowadays also called chronic reaction modes (CRM), corresponding to the different reactions of the body to the disease. Taking scabies as a model, he developed the psoric miasm; based on urethral infections and venereal warts, the sycotic miasm and on syphilis, the syphilitic miasm. Objective To provide diagnostic information in order to identify a patient's CRM so as to propose the most effective therapeutic strategy. Method By comparing our clinical experience with Hahnemann's writings, we propose the essential characteristics of each CRM, using dermatology to illustrate the point. Results Psora is by far the most frequent CRM. It corresponds to a centrifugal struggle of the body against the disease. A balanced psora means being in good health. It covers many dermatoses, allergies and common functional pathologies when it is out of balance. Conclusion The real genius and originality of Hahnemann's work lies in the discovery of CRM. It thus provides us with a wonderful means of further individualisation. However, a chronic pathology almost never corresponds to a pure CRM. It is usually the combination of two or even three CRMs often requiring multi-diathetic treatment.

The main goal of quality assurance programme is to consistently provide diagnostic information at the lowest possible cost, and at the least possible exposure of the patient to ionizing radiation. The study aims at evaluating the knowledge and practice of ray equipment among radiographers in Kano metropolis. The study design was prospective and cross sectional conducted among radiographers in the Kano metropolis from April 2019 to October 2019. Non-probability sampling meth used in the selection of the respondents. An ethical clearance to conduct the study was obtained from the Human Research and Ethics Committee of the Kano State Ministry of Health, and informed consent was obtained from every selected respondent. A s questionnaire was designed and used an instrument for data collection. The questionnaire was validated by experienced colleagues, using a pilot study the reliability was rested and the chronbach’s alpha reliability coefficient was found to be 0.7 one questionnaires were administered to the consented radiographers in Kano metropolis. The obtained data was analyzed using SPSS version 22.0. Out of the 41 (100%) administered questionnaires 36 (87%) were returned, and all the returned naires were properly filled. Only 3 (8.3%) known the meaning of quality assurance programme, only 12 (33.3%) know the components of quality assurance programme and only 6 (16.7%) know the frequency of computed radiography system average score for knowledge among radiographers in Kano metropolis is 44.9% and that of practice is 47.9%. The study concludes that radiographers in Kano metropolis have poor knowledge and pactice of quality assurance programme.

Background Pancreatitis in cats, although commonly diagnosed, still presents many diagnostic and management challenges. Objective To summarize the current literature as it relates to etiology, pathogenesis, diagnosis, and management of pancreatitis in cats and to arrive at clinically relevant suggestions for veterinary clinicians that are based on evidence, and where such evidence is lacking, based on consensus of experts in the field. Animals None. Methods A panel of 8 experts in the field (5 internists, 1 radiologist, 1 clinical pathologist, and 1 anatomic pathologist), with support from a librarian, was formed to assess and summarize evidence in the peer reviewed literature and complement it with consensus clinical recommendations. Results There was little literature on the etiology and pathogenesis of spontaneous pancreatitis in cats, but there was much in the literature about the disease in humans, along with some experimental evidence in cats and nonfeline species. Most evidence was in the area of diagnosis of pancreatitis in cats, which was summarized carefully. In contrast, there was little evidence on the management of pancreatitis in cats. Conclusions and clinical importance Pancreatitis is amenable to antemortem diagnosis by integrating all clinical and diagnostic information available, and recognizing that acute pancreatitis is far easier to diagnose than chronic pancreatitis. Although both forms of pancreatitis can be managed successfully in many cats, management measures are far less clearly defined for chronic pancreatitis.

Recognizing that breast cancers present as firm, stiff lesions, the foundation of breast magnetic resonance elastography (MRE) is to combine tissue stiffness parameters with sensitive breast MR contrast-enhanced imaging. Breast MRE is a non-ionizing, cross-sectional MR imaging technique that provides for quantitative viscoelastic properties, including tissue stiffness, elasticity, and viscosity, of breast tissues. Currently, the technique continues to evolve as research surrounding the use of MRE in breast tissue is still developing. In the setting of a newly diagnosed cancer, associated desmoplasia, stiffening of the surrounding stroma, and necrosis are known to be prognostic factors that can add diagnostic information to patient treatment algorithms. In fact, mechanical properties of the tissue might also influence breast cancer risk. For these reasons, exploration of breast MRE has great clinical value. In this review, we will: (1) address the evolution of the various MRE techniques; (2) provide a brief overview of the current clinical studies in breast MRE with interspersed case examples; and (3) suggest directions for future research.

Magnetic resonance imaging (MRI) of the right ventricle (RV) offers important diagnostic information, but the accuracy of this information is hampered by the complex geometry of the RV. Here, we propose a novel postprocessing algorithm that corrects for partial-volume effects in the analysis of standard MRI cine images of RV mass (RVm) and evaluate the method in clinical and preclinical data. Self-corrected RVm measurement was compared with conventionally measured RVm in 16 patients who showed different clinical indications for cardiac MRI and in 17 Wistar rats with different degrees of pulmonary congestion. The rats were studied under isoflurane anaesthesia. To evaluate the reliability of the proposed method, the measured end-systolic and end-diastolic RVm were compared. Accuracy was evaluated by comparing preclinical RVm to ex vivo RV weight (RVw). We found that use of the self-correcting algorithm improved reliability compared with conventional segmentation. For clinical data, the limits of agreement (LOAs) were -1.8 ± 8.6g (self-correcting) vs. 5.8 ± 7.8g (conventional), and coefficients of variation (CoVs) were 7.0% (self-correcting) vs. 14.3% (conventional). For preclinical data, LOAs were 21 ± 46 mg (self-correcting) vs. 64 ± 89 mg (conventional), and CoVs were 9.0% (self-correcting) and 17.4% (conventional). Self-corrected RVm also showed better correspondence with the ex vivo RVw: LOAs were -5 ± 80 mg (self-correcting) vs. 94 ± 116 mg (conventional) in end-diastole and -26 ± 74 mg (self-correcting) vs. 31 ± 98 mg (conventional) in end-systole. The new self-correcting algorithm improves the reliability and accuracy of RVm measurements in both clinical and preclinical MRI. It is simple and easy to implement and does not require any additional MRI data.

Background and Aims EUS remains a primary diagnostic tool for the evaluation of pancreaticobiliary disease. Although EUS combined with FNA or biopsy sampling is highly sensitive for the diagnosis of neoplasia within the pancreaticobiliary tract, limitations exist in specific clinical settings such as chronic pancreatitis. Enhanced EUS imaging technologies aim to aid in the detection and diagnosis of lesions that are commonly evaluated with EUS. Methods We reviewed technologies and methods for enhanced imaging during EUS and applications of these methods. Available data regarding efficacy, safety, and financial considerations are summarized. Results Enhanced EUS imaging methods include elastography and contrast-enhanced EUS (CE-EUS). Both technologies have been best studied in the setting of pancreatic mass lesions. Robust data indicate that neither technology has adequate specificity to serve as a stand-alone test for pancreatic malignancy. However, there may be a role for improving the targeting of sampling and in the evaluation of peritumoral lymph nodes, inflammatory pancreatic masses, and masses with nondiagnostic FNA or fine-needle biopsy sampling. Further, novel applications of these technologies have been reported in the evaluation of liver fibrosis, pancreatic cysts, and angiogenesis within neoplastic lesions. Conclusions Elastography and CE-EUS may improve the real-time evaluation of intra- and extraluminal lesions as an adjunct to standard B-mode and Doppler imaging. They are not a replacement for EUS-guided tissue sampling but provide adjunctive diagnostic information in specific clinical situations. The optimal clinical use of these technologies continues to be a focus of ongoing research.

OBJECTIVE To report on the feasibility, indications, and diagnostic yield of cone beam computed tomography (CBCT) of horses' extremities performed under standing sedation. STUDY DESIGN Retrospective clinical case series. SAMPLE POPULATION Fifty-nine CBCT examinations in 58 horses. METHODS Examinations were categorized for indications for CBCT dependent on a suspicion, presence, or absence of a diagnosis prior to CBCT. The number of acquisitions per examination, total time for the examination, diagnostic score of each acquisition (diagnostic, diagnostic-compromised, nondiagnostic), and additional diagnostic information regarding preexisting diagnostic information were recorded. RESULTS Three (median) acquisitions were performed per examination in a median study time of 14 minutes. In 24 of 33 cases with a suspected diagnosis, this diagnosis was confirmed or definitively refuted; in seven of 33 cases, the suspected diagnosis was refuted without a new diagnosis; and, in two of 33 cases, the suspected diagnosis could not be confirmed nor could a new diagnosis be made. In five of nine cases without a preexisting diagnosis, a diagnosis was established. In 16 cases with a diagnosis prior to CBCT, additional information was recorded, or a surgical plan was prepared. In 14 of 18 cases in which additional contrast techniques were used, additional information was gained. CONCLUSION Standing CBCT of the horses' extremities is feasible and can produce diagnostic information in a timely fashion. CLINICAL SIGNIFICANCE The results provide evidence of the practicality and diagnostic potential of standing CBCT of horses' extremities.

Tongue coating can provide valuable diagnostic information to reveal the disorder of the internal body. However, tongue coating classification has long been a challenging task in Traditional Chinese Medicine (TCM) due to the fact that tongue coatings are polymorphous, different tongue coatings have different colors, shapes, textures and locations. Most existing analyses utilize handcrafted features extracted from a fixed location, which may lead to inconsistent performance when the size or location of the tongue coating region varies. To solve this problem, this paper proposes a novel paradigm by employing artificial intelligence to feature extraction and classification of tongue coating. It begins with exploiting prior knowledge of rotten-greasy tongue coating to obtain suspected tongue coating patches. Based on the resulting patches, tongue coating features extracted by Convolutional Neural Network (CNN) are used instead of handcrafted features. Moreover, a multiple-instance Support Vector Machine (MI-SVM) which can circumvent the uncertain location problem is applied to tongue coating classification. Experimental results demonstrate that the proposed method outperforms state-of-the-art tongue coating classification methods.

Cancer cells shed into biofluids extracellular vesicles (EVs) - nanoscale membrane particles carrying diagnostic information. EVs shed by heterogeneous populations of tumor cells offer a unique opportunity to access biologically important aspects of disease complexity. Glioblastoma (GBM) exemplifies cancers that are incurable, because their temporal dynamics and molecular complexity evade standard diagnostic methods and confound therapeutic efforts. Liquid biopsy based on EVs offers unprecedented real-time access to complex tumour signatures, but it is not used clinically due to inefficient testing methods. We report on a nanostructured microfluidic-device that employs SERS for unambiguous identification of EVs from different GBM cell populations. The device features fabless plasmonic nanobowties for label-free and non-immunological SERS detection of EVs. This nanobowtiefluidic device combines the advanced characteristics of plasmonic nanobowties with a high throughput sample-delivery system for concentration of the analytes in the vicinity of the detection site. We showed theoretically and experimentally that the fluidic device assists the monolayer distribution of the EVs, which dramatically increase the probability of EV's existence in the laser illumination area. In addition, the optimized fabless nanobowtie structures with an average electric field enhancement factor of 9 × 105 achieve distinguishable and high intensity SERS signals. Using the nanobowtiefluidic and micro-Raman equipment, we were able to distinguish a library of peaks expressed in GBM EV subpopulations from two distinct glioblastoma cell lines (U373, U87) and compare them to those of non-cancerous glial EVs (NHA) and artificial homogenous vesicles (e.g. DOPC/Chol). This cost-effective and easy-to-fabricate SERS platform and a portable sample-delivery system for discerning the sub-population of GBM EVs and non-cancerous glial EVs may have broader applications to different types of cancer cells and their molecular/oncogenic signature.

The article discusses the issues of modeling conditions for obtaining diagnostic information about complex objects. As an example, the study of the braking qualities of four-wheel drive cars on an inertial roller stand is considered. Diagnosing the technical condition of cars from the point of view of traffic safety is one of the most important problems. This is especially important for systems whose technical condition affects traffic safety: especially braking systems. Foreign and domestic experience testifies to the effectiveness of instrumental control. The diagnostic equipment includes roller stands, on which you can check the braking properties of cars. As shown by many studies, in particular, carried out at the Department of Technical Operation and Service of Automobiles, KhNADU (HADI), inertial stands provide more reliable information about the technical condition of the car. Such stands allow you to reproduce the real speed and thermal modes of the brakes (especially those equipped with ABS). To improve the accuracy of diagnosing a car on a roller stand, it is necessary to have an idea of the nature of the interaction of the car wheels with the rollers. The studies of wheel rolling on the stand rollers have been carried out by many authors since the 80s of the last century. However, all these studies were carried out on uniaxial stands and for mono-drive vehicles. Nowadays, a large number of passenger cars have four-wheel drive. Rolling of the wheels of such cars on rollers and their interaction has practically not been studied. Therefore, a return to the study of this issue is relevant. A power model of the system of interaction between the car and the stand has been developed, taking into account the design features of the stand and the design features of the car's suspension. The power model of the system under consideration contains the equilibrium equations of the body and two bridges and the equations of motion of the rollers and wheels of the car. Based on the results of the analysis of the acting forces in the "car-stand" system, the braking moments on the wheels M and the coefficients of the use of the load q during the braking tests of a 4x4 vehicle were determined. The obtained research results allowed to improve the theory of interaction of a car wheel with the rollers of an inertial diagnostic stand.

In the mechanized power transmission applications one of the crucial elements used to transmit power/motion is gear. Gear faults developed in rotating machines during operating conditions directly affects the performance of the power transmission system. The vibration/acoustic signal monitoring and analysis techniques extensively used in industry to detect and diagnose the incipient faults developed on the contact surfaces of gear tooth. The vibration/acoustic signals acquired from the gearbox are post processed by using signal-processing techniques to achieve cost-effective manufacturing and enhancement in the performance of rotating machines. This paper describes the results of experimental investigations carried out to detect and diagnose the simulated faults in two stage helical gearbox. The vibration and acoustic signals acquired from the gearbox to extract the fault related features. The bispectrum analysis technique used to detect the local fault simulated on the helical gear tooth. Results provided a better fault diagnostic information rather than conventional frequency spectrum analysis.

Polar Mesosphere Summer Echoes (PMSEs) are very strong radar echoes observed at altitudes near the polar summer mesopause. One of the essential properties of these radar echoes is that they can give useful diagnostic information about the physics of the scattering process. In this paper, the related characteristics of PMSEs measured with the European Incoherent SCATter Very High Frequency (EISCAT VHF) 224 MHz radar on 13–15 July 2010 are studied at different elevation angles from 78° to 90°. It is found that the PMSEs peak power and strongest PMSEs average power occur at the same elevation angles. Also interesting is that the strongest PMSEs occur at off-vertical angles when a PMSEs has a layered (multilayer) structure. And reflection may have more significant effects on PMSEs when there are double or multilayer PMSEs. Possible explanations regarding these observations are discussed.

Diagnosing teachers are teachers who perceive diagnostic information about students’ learning process, interpret these aspects, decide how to respond, and act based on this diagnostic decision. During supervision meetings about the undergraduate thesis supervisors make in-the-moment decisions while interacting with their students. We regarded research supervision as a teaching process for the supervisor and a learning process for the student. We tried to grasp supervisors’ in-the-moment decisions and students’ perceptions of supervisors’ actions. Supervisor decisions and student perceptions were measured with video-stimulated recall interviews and coded using a content analysis approach. The results showed that the in-the-moment decisions our supervisors made had a strong focus on student learning. Supervisors often asked questions to empower students or to increase student understanding. These supervising strategies seemed to be adapted to students’ needs, as the latter had positive perceptions when their control increased or when they received stimuli to think for themselves. published

Neuropsychological studies have shown that prosopagnosic individuals perceive face structure in an atypical way. This might preclude the formation of appropriate face representations and, consequently, hamper effective recognition. The present ERP study, in combination with Bayesian source reconstruction, investigates how information related to both external (E) and internal (I) features was processed by E.C. and I.P., suffering from acquired and developmental prosopagnosia, respectively. They carried out a face-feature matching task with new faces. E.C. showed poor performance and remarkable lack of early face-sensitive P1, N170 and P2 responses on right (damaged) posterior cortex. Although she presented the expected mismatch effect to target faces in the E-I sequence, it was of shorter duration than in Controls, and involved left parietal, right frontocentral and dorsofrontal regions, suggestive of reduced neural circuitry to process face configurations. In turn, I.P. performed efficiently but with a remarkable bias to give “match” responses. His face-sensitive potentials P1–N170 were comparable to those from Controls, however, he showed no subsequent P2 response and a mismatch effect only in the I-E sequence, reflecting activation confined to those regions that sustain typically the initial stages of face processing. Relevantly, neither of the prosopagnosics exhibited conspicuous P3 responses to features acting as primes, indicating that diagnostic information for constructing face representations could not be sufficiently attended nor deeply encoded. Our findings suggest a different locus for altered neurocognitive mechanisms in the face network in participants with different types of prosopagnosia, but common indicators of a deficient allocation of attentional resources for further recognition.

This article is about assessing the reliability and in-operation risks of vehicles with the help of diagnostic information. The information about the health status of an automobile can come from data from integrated remote and stationary diagnostic systems. The main aim of assessing risks and creating remote diagnostic systems is to predict the operational reliability and safety of automobiles. To solve this problem, it is necessary to identify in a timely manner and then prevent the occurrence of malfunctions, which requires distinguishing a special class of intermediate statuses called pre-accident conditions. Information about each model can be obtained, and the respective statistical data can be accumulated on the condition that the necessary remote diagnostic systems are created.

In this Letter, the authors propose a variational mode decomposition method for quantifying diagnostic information of myocardial infarction (MI) from the electrocardiogram (ECG) signal. The multiscale mode energy and principal component (PC) of multiscale covariance matrices are used as features. The mode energies determine the strength of the mode, and the PCs provide the representation of the ECG signal with less redundancy. K-nearest neighbour and support vector machine classifier are utilised to assess the performance of the extracted features for the detection and classification of MI and normal (healthy control). The proposed method achieved a specificity of 99.88%, sensitivity of 99.90%, and accuracy of 99.88%. Experimental results demonstrate that the proposed method with the multiscale mode energy and PC features achieved better output compared to the previously published work.

Over the last 2 decades, the proliferation of magnetic resonance imaging (MRI) availability and continuous improvements in acquisition speeds have led to significantly increased MRI utilization across the health care system, and MRI studies are increasingly ordered in the emergent setting. Depending on the clinical presentation, MRI can yield vital diagnostic information not detectable with other imaging modalities. The aim of this text is to report on the up-to-date indications for MRI of the spine in the ED, and review the various MRI appearances of commonly encountered acute spine pathology, including traumatic injuries, acute non traumatic myelopathy, infection, neoplasia, degenerative disc disease, and postoperative complications. Imaging review will focus on the aspects of the disease process that are not readily resolved with other modalities.

Introduction An important cause of laboratory test misordering and overutilization is clinician confusion between tests with similar sounding names or similar indications. We identified an area of test ordering confusion with iron studies that involves total iron binding capacity (TIBC), transferrin, and transferrin saturation. We observed concurrent ordering of direct transferrin along with TIBC at many hospitals within our health system and suspected this was unnecessary. Methods We extracted patient test results for transferrin, TIBC and other biomarkers. Using these data, we evaluated both patterns of test utilization and test result concordance. We implemented a clinical decision support (CDS) alert to discourage unnecessary orders for direct transferrin. Results Using linear regression, we were able to predict transferrin from either TIBC alone or TIBC with other analytes with a high degree of accuracy, demonstrating that in most cases, direct transferrin in combination with TIBC provides little if any additional diagnostic information beyond TIBC alone. The CDS alert proved highly effective in reducing transferrin test utilization at four different hospitals. Conclusions Concurrent ordering of direct transferrin and TIBC should usually be avoided. Removal of transferrin or TIBC from the test menu or implementation of CDS may improve utilization of these tests.

Concerns about the potentially stigmatizing impact of psychopathy evidence in court have been expressed for decades. Saks et al. manipulated diagnostic information (e.g., psychopathy, schizophrenia) and the basis for that evidence (e.g., clinical, neuroimaging) to examine effects on outcomes in two capital murder case vignettes. Somewhat surprisingly, their psychopathy manipulation did not have a consistently adverse impact on juror attitudes relative to other diagnoses or a control condition. We administered the Saks et al. stimulus materials to college students ( N = 569), but added a scale quantifying participant ratings of how psychopathic they perceived the defendant to be. Notably, we obtained uniformly high mean psychopathy ratings across all study conditions. In addition, participants who rated the defendant as more psychopathic (regardless of condition) were more likely to support death verdicts. We discuss the implications of our results in terms of the design of experimental manipulations of mental health evidence for jury simulations.

Cognitive diagnosis models (CDMs) have been studied as a means of providing detailed diagnostic information about the skills that have been mastered, and the skills that have not, by examinees. Pri...

Methods of diagnosing and monitoring pediatric musculoskeletal infections are rapidly evolving. Key serologic tests are typically used in screening patients with suspected infections, and remain an integral part of the initial work-up. Synovial studies from arthrocentesis in possible septic arthritis, and source-specific cultures have been the foundation of our treatment algorithm. Given the prevalence of soft tissue abscesses and osteoarticular infections, advanced imaging is an advantageous tool. More affordable use and expanded access to MRI has made it a valuable adjunct to clinical picture and existing tests in order to comprehensively visualize the extent of musculoskeletal infections in children. Ongoing validation for criteria to help determine the patients that stand to benefit the most from MRI, even when surgical intervention may be delayed, remains of significant clinical interest. Given the rates of culture-negative infections, and the need for timely diagnosis, new diagnostic techniques are always being considered. The search for more accurate biomarkers, and technology such as Whole genome sequencing (WGS) and next-generation sequencing (NGS) that can rapidly identify pathogens of all types of phyla based on a small sample of DNA, has promising clinical implications. While once novel and prohibitively expensive, these tests are now being applied in university and tertiary care centers in certain scenarios. Applying these techniques to pediatric musculoskeletal will require a large change in lab workflow and training. However, the benefits of acquiring diagnostic information along with will make them a superior tool in our arsenal of diagnostic tests.

A pressing concern with the eyewitness testimony used in many criminal cases is that jurors may be swayed by the high confidence of an eyewitness and, as a result, may disregard other factors that provide more diagnostic information. Mock jurors were surveyed using a large national sample of 1,684 laypeople, selected to be representative of the U.S. population (age, race, gender, geographic region), using mock trial videos of eyewitness testimony. To explore the relationship between courtroom confidence and other factors, we used a fractional factorial design, permitting examination of the relationships among seven factors. Among these seven factors, we found that jurors gave most weight to the confidence of eyewitnesses, especially that expressed in the courtroom, irrespective of the eyewitness's testimony about confidence (low or high) at the initial police lineup. Jurors' assessments were not sensitive to the other factors or their interactions in the experiment: crime type (burglary or sexual assault), the race of the defendant and eyewitness, or information provided in judicial instructions or by expert testimony. The disproportionate importance of the eyewitness's expressed confidence has implications for the effectiveness of legal efforts to inform jurors about factors affecting eyewitness memory.

Background To assess whether whole-body (WB) bone SPECT/CT provides additional diagnostic information over [18F]-FCH PET/CT for the detection of bone metastases in the setting of prostate cancer biochemical recurrence (PC-BR). Methods Patients referred for a PC-BR and whom benefited from a WB bone SPECT/CT and FCH PET/CT were retrospectively included. Tests were classified as positive, equivocal, or negative for bone metastases. A best valuable comparator (BVC) strategy including imaging and follow-up data was used to determine the metastatic status in the absence of systematic histological evaluation. Results Between January 2011 and November 2017, 115 consecutive patients with a PC-BR were evaluated. According to the BVC, 30 patients had bone metastases and 85 patients did not present with bone lesions. The sensitivity, specificity, positive and negative predictive values were respectively 86.7% [69.3–96.2], 98.8% [93.6–100.0], 96.3% [78.7–99.5], and 95.5% [89.4–98.1] for WB bone SPECT/CT and 93.3% [77.9–99.2], 100.0% [95.8–100.0], 100.0 and 97.7% [91.8–99.4] for FCH PET/CT. There was no significant difference in diagnostic accuracy of bone metastases between WB Bone SPECT/CT (AUC 0.824 [0.74–0.90]) and FCH PET/CT (AUC 0.829 [0.75–0.90], p = 0.41). Conclusion Despite good performances for the diagnosis of bone metastases in PC-BR, WB bone SPECT/CT does not provide additive diagnostic information over concomitant FCH PET/CT.

Across many industries, individuals are increasingly relying on customer ratings and reviews on social media. While customer reviews often provide detailed diagnostic information about experiences, customer ratings often reduce the experience down to a simple number. Moreover, there is evidence to support that customer rating inflation is occurring on social media sites over time, especially in the sharing economy, and especially with regard to travel and tourism experiences. This paper conceptualizes how customer experiences are reduced into customer reviews and further abridged into customer ratings in both the traditional and sharing economy contexts. We propose that customers observe how service providers present themselves as a professional (established chain hotel) or amateur (owner operated vacation rental apartment), and then form different service expectations and perceptions accordingly. We investigate 55,110 customer reviews and ratings of New York City’s accommodation providers and indeed find evidence of rating inflation over the eight years studied. QC 20200228

New methods for retrieving localized diagnostic information from cyclic signals of complex shape are proposed. The advantages of an alternative method of estimating the shape of an averaged cycle based on transition from a scalar signal to its mapping on the phase plane are shown. Original methods are proposed for estimating the dynamics of parameters characterizing the shape of informative fragments of the signal, based on construction of the convex hull of the phase portrait of permutation entropy and the Levenshtein distance.

Purpose With the initiation of human hyperpolarized 13 C (HP-13 C) trials at multiple sites and the development of improved acquisition methods, there is an imminent need to maximally extract diagnostic information to facilitate clinical interpretation. This study aims to improve human HP-13 C MR spectroscopic imaging through means of Tensor Rank truncation-Image enhancement (TRI) and optimal receiver combination (ORC). Methods A data-driven processing framework for dynamic HP 13 C MR spectroscopic imaging (MRSI) was developed. Using patient data sets acquired with both multichannel arrays and single-element receivers from the brain, abdomen, and pelvis, we examined the theory and application of TRI, as well as 2 ORC techniques: whitened singular value decomposition (WSVD) and first-point phasing. Optimal conditions for TRI were derived based on bias-variance trade-off. Results TRI and ORC techniques together provided a 63-fold mean apparent signal-to-noise ratio (aSNR) gain for receiver arrays and a 31-fold gain for single-element configurations, which particularly improved quantification of the lower-SNR-[13 C]bicarbonate and [1-13 C]alanine signals that were otherwise not detectable in many cases. Substantial SNR enhancements were observed for data sets that were acquired even with suboptimal experimental conditions, including delayed (114 s) injection (8× aSNR gain solely by TRI), or from challenging anatomy or geometry, as in the case of a pediatric patient with brainstem tumor (597× using combined TRI and WSVD). Improved correlation between elevated pyruvate-to-lactate conversion, biopsy-confirmed cancer, and mp-MRI lesions demonstrated that TRI recovered quantitative diagnostic information. Conclusion Overall, this combined approach was effective across imaging targets and receiver configurations and could greatly benefit ongoing and future HP 13 C MRI research through major aSNR improvements.

Implicit evaluations (attitudes) are often described as resistant to change, especially when they were initially formed in a seemingly associative manner, such as via repeated evaluative pairings (REP), and new learning is created via propositional material, such as evaluative statements (ES). The present research (total N = 2,124) tested the responsiveness of implicit evaluations instantiated via REP to updating via different types of ES. In Experiment 1, initial learning was created via repeatedly pairing a novel target with strongly negative stimuli (screams) in an aversive REP (A-REP) task. Subsequent ES of opposing valence providing diagnostic information about the target's behavior substantially updated implicit (IAT) evaluations. In Experiment 2, behavioral ES resulted in successful updating after A-REP whether or not they provided an explanation for the initial A-REP learning. A previously unobtained result emerged in Experiment 3 showing that updating was durable even after 1 day. Finally, in Experiment 4, implicit evaluations were updated via diagnostic behavioral ES, but not via an ES instruction to suppose that different pairings had occurred during A-REP. Taken together, these experiments challenge associative theories of implicit evaluation by demonstrating that diagnostic behavioral statements can durably override the effects of initial learning on implicit evaluations, even if such initial learning is aversive and involves direct experience with stimulus pairings. Moreover, by showing that verbal manipulations based on diagnostic behavior but not a mere supposition instruction had impact, the present project advances theory by starting to identify the nature of learning that can adaptively update social impressions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Imaging evaluation of the shoulder is performed using multiple modalities, including ultrasound (US) and MR imaging. Clinicians often wonder which modality to use to work up their patients with shoulder pain. Although MR imaging has remained the workhorse of shoulder imaging, US has increased in popularity among academic and private institutions. Both modalities offer similar diagnostic information in regards to rotator cuff pathology and other soft tissues, although they differ in their technique, indications, and interpretation. A thorough understanding of these differences is imperative to appropriately use these modalities in clinical practice, including the unique interventional opportunities available with US.

Studies have shown that the traces people leave when browsing the internet may indicate the onset of diseases such as cancer. Here we show that the adaptive engines of advertising systems in conjunction with clinically verified questionnaires can be used to identify people who are suspected of having one of three types of solid tumor cancers. In the first study, 308 people were recruited through ads shown on the Bing search engine to complete a clinically verified risk questionnaire. A classifier trained to predict questionnaire response using only past queries on Bing reached an Area Under the Curve of 0.64 for all three cancer types, verifying that past searches could be used to identify people with suspected cancer. The second study was conducted using the Google ads system in the same configuration as in the first study. However, in this study the ads system was set to automatically learn to identify people with suspected cancer. A total of 70,586 people were shown the ads, and 6,484 clicked and were referred to complete the clinical questionnaires. People from countries with higher Internet access and lower life expectancy tended to click more on the ads. Over time the advertisement system learned to identify people who were likely to have symptoms consistent with suspected cancer, such that the percentage of people completing the questionnaires and found to have suspected cancer reached approximately 11\% at the end of the experiment. These results demonstrate the utility of using search engine queries to screen for possible cancer and the application of modern advertising systems to help identify people who are likely suffering from serious medical conditions. This is especially true in countries where medical services are less developed.

Summary Background Bioimpedance spectroscopy (BIS) is used to assess lymphedema by measuring limb fluid content as an electric current passes through cell membranes and tissues. There are two primary device modalities, through which BIS is used clinically: single-segment bioimpedance (SSB) and multi-segment bioimpedance (MSB), which differ in their mechanisms of gathering measurements. In this cross-sectional study, we study the difference between SSB and MSB in evaluating lymphedema by referencing the results with indocyanine Green (ICG) lymphography. Methods Patients with unilateral and bilateral lymphedema, presented to our department, were assessed with both SSB and MSB as part of a pre-lymphatic surgery evaluation between May 1, 2017, and November 31, 2017. Patients were imaged with ICG lymphography to confirm lymphedema presence. Standardized device measurement outputs from SSB and MSB were recorded and statistically analyzed. Results SSB was more sensitive (0.9) than MSB (0.75) for unilateral lymphedema. However, MSB had the added ability to assess patients with bilateral lymphedema with a sensitivity of 0.56 and specificity of 0.60. Furthermore, MSB had a stronger correlation with relative disease severity compared to SSB and quantified the differential extents of edema. In comparison, SSB provided a manipulated number, which was derived from a comparison of the abnormal to the normal limb. Medical staff reported MSB being easier to perform, and all patients reported the MSB measurement experience being more favorable. Conclusions While both SSB and MSB provide diagnostic information on lymphedema, MSB is notably easier to perform, can detect bilateral disease states, and objectively quantifies limb fluid volume, allowing for disease tracking and assessment of surgical and rehabilitative treatment efficacy. On the basis of this study, our department has switched to universal MSB measurement.