Search

Your search keyword '"Dhar, Manoj K."' showing total 299 results
Start Over Author "Dhar, Manoj K."
299 results on '"Dhar, Manoj K."'

57. Cytogenetic Diversity in Scilloideae (Asparagaceae): a Comprehensive Recollection and Exploration of Karyo-Evolutionary Trends

Author

Nath, Sayantani, primary, Sarkar, Sayantika, additional, Patil, Sayali D., additional, Saha, Partha Sarathi, additional, Lekhak, Manoj M., additional, Ray, Sudipta, additional, Rao, Satyawada Rama, additional, Yadav, S. R., additional, Verma, R. C., additional, Dhar, Manoj K., additional, Raina, S. N., additional, and Jha, Sumita, additional

Published
2022
Full Text
View/download PDF

73. Induction of polyploidy in saffron (Crocus sativus L.) using colchicine.

Author

Kashtwari, Mahpara, Jan, Sabbi, Wani, Aijaz A., and Dhar, Manoj K.

Subjects
SAFFRON crocus, POLYPLOIDY, PLANT breeding, CELL morphology, COLCHICINE
Abstract

Saffron (Crocus sativus L.) is triploid (2 n = 3x = 24, x = 8), which limits its improvement through crop breeding programs. This study was initiated to induce hexaploidy with the intent of restoring sexual stability in saffron. Corms were treated with colchicine concentrations of 0.0%, 0.025%, 0.05%, and 0.1% for 3-h, 6-h, and 9-h. A total of 16 in-vitro shoots showed signs of polyploidization. These colchiploid shoots showed slow but robust growth and produced large-sized cormlets (6.0 g) compared to the control (2.8 g). Leaf epidermal cell morphology, stomatal size and density showed evidence of polyploidization. Hexaploidy (2 n = 6x = 48) was confirmed by root-tip cytology. The hexaploid corms germinated but could not establish in the field. We were able to develop a protocol for in-vitro induction of hexaploidy in C. sativus, but the subsequent growth of hexaploid corms in the field remains a major challenge in restoring the sexual stability in saffron. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

78. Anti-bacterial activity of neoandrographolide derivatives: In silico interaction with the bacterial target.

Author

Sharma, Venu, Sharma, Supriya, Mehra, Rukmankesh, Kapoor, Kamal K., Dhar, Manoj K., and Kaul, Sanjana

Subjects
ANDROGRAPHIS paniculata, ANTIBACTERIAL agents, NATURAL products, ANTIBIOTICS, MEDICINAL plants
Abstract

Natural products and their semi synthesized molecules have been used as efficient antibiotics since a long time. The present global health scenario has raised the demand for novel antimicrobial agents and drug targets that are effective against drug resistant pathogens, emerging infections etc. The current study has promoted the antibacterial activity of the glucoside labdane 'neoandrographolide', isolated from the methanolic extract of the medicinal plant Andrographis paniculata. Further modification at its glucoside hydroxyl groups to generate ester and acetonide derivatives was done and the antibacterial potential of these compounds was screened against common bacterial pathogens. Among various derivatives, 4',6'-O-(4-methoxybenzylidene) neoandrographolide exhibited promising results. In addition, molecular modeling study of the active compound was also explored to identify its probable binding mode on the bacterial target. The present study reported antibacterial activity of neoandrographolide derivatives for first time and also the bioactive molecule, 4',6'-O-(4-methoxybenzylidene) neoandrographolide was examined as a potent antibacterial agent against different strains. [ABSTRACT FROM AUTHOR]

Published
2022

85. Assessment of Apple (malus × Domestica Bark.) Germplasm of Kashmir Using RAPD Markers.

Author

Dar, Jahangir A., Wani, Aijaz A., and Dhar, Manoj K.

Subjects
GERMPLASM, CROP quality, BARK, APPLES, CULTIVARS, TIME management
Abstract

The availability of diverse germplasm of any crop is an important genetic resource to mine the genes that may assist in attaining food as well as the nutritional quality of the crop. In the present study, a total of 10 RAPD markers were used for the first time in the Kashmir apple germplasm to elucidate diversity among 19 apple cultivars collected from various parts of the Valley. The discriminatory power of each random primer was observed using various parameters like: polymorphic information content, resolving power and marker index. A total of 70 polymorphic bands were observed with a percentage polymorphism of 83.33. Cultivars differentiated through mutations like Oregon Spur, Reeka Red, and Silver Spur were also included in this study and have shown identical banding patterns among each other. The dendrogram generated by using NTSYS grouped cultivars into two major clusters with various degrees of sub-clustering within the cluster. These findings will be helpful for further research programs on apple and have implications in apple breeding as well as in conservation programs. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

90. Replication of MACF1 gene variant rs2296172 with type 2 diabetes susceptibility in the Bania population group of Punjab, India

Author

Sharma, Varun, primary, Sethi, Itty, additional, Sharma, Indu, additional, Singh, Gurvinder, additional, Mahajan, Ankit, additional, Angural, Arshia, additional, Bhanwer, A. J. S., additional, Dhar, Manoj K., additional, Pandita, K. K., additional, Singh, Vinod, additional, Rai, Ekta, additional, and Sharma, Swarkar, additional

Published
2017
Full Text
View/download PDF

91. In vitroAntioxidant, Antimutagenic and Anti-hemolytic Potency of Allyl Isothiocyanate: A Natural Molecule

Author

Bhushan, Sakshi, Rajput, Sneh, Sharma, Deepak, Kaur, Tajinder, Dhar, Manoj K., and Arora, Saroj

Abstract

AbstractThe cruciferous vegetables are richest sources of isothiocyanates and among them, allyl isothiocyanate (AITC) is one of the major constituents. It has been known to possess various activities of therapeutic interest. Keeping this in view, the present study was planned to investigate antioxidant capacity of AITC using Cupric Reducing Antioxidant Capacity (CUPRAC) Assay, 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay, β-Carotene bleaching (BCB) assay and superoxide anion scavenging assay. The antimutagenic potency of AITC was determined by modifying Vibrio harveyibioluminescence assay against direct acting mutagen 4-nitro-o-phenylenediamine (NPD) and indirect acting mutagens 2-acetylaminofluorene (2-AAF), 7,12-Dimethylbenz[a]anthracene (DMBA) in presence and absence of S9. Furthermore, the antihemolytic activity was evaluated using hemolysis assay. Among the different activities carried out, it was observed that AITC exhibited efficient antimutagenic potential against direct acting mutagen NPD and indirect acting mutagens 2-AAF and DMBA in the presence as well as absence of S9 fraction in Vibrio harveyibioluminescence assay. Overall, our results established the efficiency of AITC to act as strong antimutagenic agent, efficient anti-hemolytic agent and mild antioxidant agent thus, making AITC an interesting candidate to be further explored for drug discovery.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results