398 results on '"Dexheimer P"'
Search Results
52. Clinical utility of periodic reinterpretation of CNVs of uncertain significance: an 8-year retrospective study
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Ravel, Jean-Marie, Renaud, Mathilde, Muller, Jean, Becker, Aurélie, Renard, Émeline, Remen, Thomas, Lefort, Geneviève, Dexheimer, Mylène, Jonveaux, Philippe, Leheup, Bruno, Bonnet, Céline, and Lambert, Laëtitia
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- 2023
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53. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer
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Bedard, Mary C., Chihanga, Tafadzwa, Carlile, Adrean, Jackson, Robert, Brusadelli, Marion G., Lee, Denis, VonHandorf, Andrew, Rochman, Mark, Dexheimer, Phillip J., Chalmers, Jeffrey, Nuovo, Gerard, Lehn, Maria, Williams, David E. J., Kulkarni, Aditi, Carey, Molly, Jackson, Amanda, Billingsley, Caroline, Tang, Alice, Zender, Chad, Patil, Yash, Wise-Draper, Trisha M., Herzog, Thomas J., Ferris, Robert L., Kendler, Ady, Aronow, Bruce J., Kofron, Matthew, Rothenberg, Marc E., Weirauch, Matthew T., Van Doorslaer, Koenraad, Wikenheiser-Brokamp, Kathryn A., Lambert, Paul F., Adam, Mike, Steven Potter, S., and Wells, Susanne I.
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- 2023
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54. Combining information centric and software defined networking to support command and control agility in military mobile networks
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Matiuzzi Stocchero, Jorgito, Dexheimer Carneiro, Andre, Zacarias, Iulisloi, and Pignaton de Freitas, Edison
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- 2023
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55. Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease.
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Haberman, Yael, Minar, Phillip, Karns, Rebekah, Dexheimer, Phillip J, Ghandikota, Sudhir, Tegge, Samuel, Shapiro, Daniel, Shuler, Brianne, Venkateswaran, Suresh, Braun, Tzipi, Ta, Allison, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Rosh, Joel, Markowitz, James, Dotson, Jennifer L, Mack, David R, Kellermayer, Richard, Griffiths, Anne M, Heyman, Melvin B, Baker, Susan S, Moulton, Dedrick, Patel, Ashish S, Gulati, Ajay S, Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Gokhale, Ranjana, Kim, Sandra, Guthery, Stephen L, Cohen, Stanley A, Snapper, Scott, Aronow, Bruce J, Stephens, Michael, Gibson, Greg, Dillman, Jonathan R, Dubinsky, Marla, Hyams, Jeffrey S, Kugathasan, Subra, Jegga, Anil G, and Denson, Lee A
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Crohn's Disease ,Pediatric ,Clinical Research ,Genetics ,Digestive Diseases ,Inflammatory Bowel Disease ,Paediatric Crohn disease ,ileum ,small molecule ,surgery ,transcriptome ,pediatric Crohn Disease ,Clinical Sciences ,Gastroenterology & Hepatology - Abstract
Ileal strictures are the major indication for resective surgery in Crohn's disease (CD). We aimed to define ileal gene programs present at diagnosis linked with future stricturing behavior during five year follow-up, and to identify potential small molecules to reverse these gene signatures. Antimicrobial serologies and pre-treatment ileal gene expression were assessed in a representative subset of 249 CD patients within the RISK multicenter pediatric CD inception cohort study, including 113 that are unique to this report. These data were used to define genes associated with stricturing behavior and for model testing to predict stricturing behavior. A bioinformatics approach to define small molecules which may reverse the stricturing gene signature was applied. 19 of the 249 patients developed isolated B2 stricturing behavior during follow-up, while 218 remained B1 inflammatory. Using deeper RNA sequencing than in our prior report, we have now defined an inflammatory gene signature including an oncostatin M co-expression signature, tightly associated with extra-cellular matrix (ECM) gene expression in those who developed stricturing complications. We further computationally prioritize small molecules targeting macrophage and fibroblast activation and angiogenesis which may reverse the stricturing gene signature. A model containing ASCA and CBir1 serologies and a refined eight ECM gene set was significantly associated with stricturing development by year five after diagnosis (AUC (95th CI) = 0.82 (0.7-0.94)). An ileal gene program for macrophage and fibroblast activation is linked to stricturing complications in treatment naïve pediatric CD, and may inform novel small molecule therapeutic approaches.
- Published
- 2021
56. On the Deconfinement Phase Transition in Neutron-Star Mergers
- Author
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Most, Elias R., Papenfort, L. Jens, Dexheimer, Veronica, Hanauske, Matthias, Stöcker, Horst, and Rezzolla, Luciano
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology ,Nuclear Theory - Abstract
We study in detail the nuclear aspects of a neutron-star merger in which deconfinement to quark matter takes place. For this purpose, we make use of the Chiral Mean Field (CMF) model, an effective relativistic model that includes self-consistent chiral symmetry restoration and deconfinement to quark matter and, for this reason, predicts the existence of different degrees of freedom depending on the local density/chemical potential and temperature. We then use the out-of-chemical-equilibrium finite-temperature CMF equation of state in full general-relativistic simulations to analyze which regions of different QCD phase diagrams are probed and which conditions, such as strangeness and entropy, are generated when a strong first-order phase transition appears. We also investigate the amount of electrons present in different stages of the merger and discuss how far from chemical equilibrium they can be and, finally, draw some comparisons with matter created in supernova explosions and heavy-ion collisions., Comment: 10 pages, 6 figures
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- 2019
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57. Equation of State of Hot Dense Hyperonic Matter in the Quark-Meson-Coupling (QMC-A) model
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Stone, J. R., Dexheimer, V., Guichon, P. A. M., Thomas, A. W., and Typel, S.
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We report a new equation of state (EoS) of cold and hot hyperonic matter constructed in the framework of the quark-meson-coupling (QMC-A) model. The QMC-A EoS yields results compatible with available nuclear physics constraints and astrophysical observations. It covers the range of temperatures from T=0 to 100 MeV, entropies per particle S/A between 0 and 6, lepton fractions from Y$_L$=0.0 to 0.6, and baryon number densities n$_B$=0.05-1.2 fm$^{-3}$. Applications of the QMC-A EoS are made to cold neutron stars (NS) and to hot proto-neutron stars (PNS) in two scenarios, (i) lepton rich matter with trapped neutrinos and (ii) deleptonized chemically equilibrated matter. We find that the QMC-A model predicts hyperons in amounts growing with increasing temperature and density, thus suggesting not only their presence in PNS but also, most likely, in NS merger remnants. The nucleon-hyperon phase transition is studied through the adiabatic index and the speed of sound c$_s$. It is shown that the lowering of (c$_s$/c)$^2$ to and below the conformal limit of 1/3 is a general consequence of instabilities due to any phase transition and is not a unique fingerprint of the hadron-quark matter transition. Rigid rotation of cold and hot stars, their moments of inertia and Kepler frequencies are also explored. The QMC-A model results are compared with two relativistic models, the chiral mean field model (CMF), and the generalized relativistic density functional with hyperons (GRDF-Y). Similarities and differences are discussed., Comment: 14 pages, 14 figures. Final version accepted for publication in MNRAS 2020 December 17
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- 2019
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58. Neutron-Star-Merger Equation of State
- Author
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Dexheimer, Veronica, Constantinou, Constantinos, Most, Elias R., Papenfort, L. Jens, Hanauske, Matthias, Schramm, Stefan, Stoecker, Horst, and Rezzolla, Luciano
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
In this work, we discuss the dense matter equation of state (EOS) for the extreme range of conditions encountered in neutron stars and their mergers. The calculation of the properties of such an EOS involves modeling different degrees of freedom (such as nuclei, nucleons, hyperons, and quarks), taking into account different symmetries, and including finite density and temperature effects in a thermodynamically consistent manner. We begin by addressing subnuclear matter consisting of nucleons and a small admixture of light nuclei in the context of the excluded volume approach. We then turn our attention to supranuclear homogeneous matter as described by the Chiral Mean Field (CMF) formalism. Finally, we present results from realistic neutron-star-merger simulations performed using the CMF model that predict signatures for deconfinement to quark matter in gravitational wave signals., Comment: Contribution to the Special Issue "Compact Stars in the QCD Phase Diagram and in the Multi-Messenger Era of Astronomy" dedicated to the conference: Compact Stars in the QCD Phase Diagram VII
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- 2019
59. The Equation of State and Cooling of Hyperonic Neutron Stars
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Tolos, Laura, Centelles, Mario, Ramos, Angels, Negreiros, Rodrigo, and Dexheimer, Veronica
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Astrophysics - High Energy Astrophysical Phenomena ,Nuclear Theory - Abstract
We present two recent parametrizations of the equation of state (FSU2R and FSU2H models) that reproduce the properties of nuclear matter and finite nuclei, fulfill constraints on high-density matter stemming from heavy-ion collisions, produce 2$M_{\odot}$ neutron stars, and generate neutron star radii below 13 km. Making use of these equations of state, cooling simulations for isolated neutron stars are performed. We find that two of the models studied, FSU2R (with nucleons) and, in particular, FSU2H (with nucleons and hyperons), show very good agreement with cooling observations, even without including nucleon pairing. This indicates that cooling observations are compatible with an equation of state that produces a soft nuclear symmetry energy and, thus, generates small neutron star radii. Nevertheless, both schemes produce cold isolated neutron stars with masses above $1.8 M_{\odot}$., Comment: 6 pages, 4 figures, 1 table, invited parallel talk at Fifteenth Marcel Grossmann Meeting, University of Rome "La Sapienza" - Rome, July 1-7, 2018
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- 2019
60. Limiting magnetic field for minimal deformation of a magnetised neutron star
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Gomes, R. O., Pais, Helena, Dexheimer, V., Providência, Constança, and Schramm, S.
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
In this work we study the structure of neutron stars under the effect of a poloidal magnetic field and determine the limiting highest magnetic field intensity which still allows a satisfactory description of magnetic neutron stars in the spherical symmetry regime. We describe different compositions of stars (nucleonic, hyperonic, and hybrid), using three state-of-the-art relativistic mean field models for the microscopic description of matter, which are in agreement with experimental and observational data. The structure of stars is described by the general relativistic solution of both Einstein's field equations assuming a spherical symmetry, and Einstein-Maxwell's field equations assuming an axi-symmetric deformation. We find a limiting magnetic moment of the order of $2\times 10^{31}$Am$^2$, which corresponds to magnetic fields of the order of 10$^{16}$ G at the surface, and $ \sim 10^{17}$ G at the centre of the star, above which the deformation due to the magnetic field is not negligible. We show that the intensity of the magnetic field developed in the star depends on the EoS, and, for a given baryonic mass and fixed magnetic moment, larger fields are attained with softer EoS. We also show that the appearance of exotic degrees of freedom, such as hyperons or a quark core, is disfavored in the presence of a very strong magnetic field. As a consequence, a highly magnetized nucleonic star may suffer an internal conversion due to the decay of the magnetic field, which could be accompanied by a sudden cooling of the star or a gamma ray burst.
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- 2019
- Full Text
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61. Phase Transitions in Neutron Stars
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Dexheimer, V., Soethe, L. T. T., Roark, J., Gomes, R. O., Kepler, S. O., and Schramm, S.
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Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
In this paper we review the most common descriptions for the first order phase transition to deconfined quark matter in the core of neutron stars. We also present a new description of these phase transitions in the core of proto-neutron stars, in which more constraints are enforced so as to include trapped neutrinos. Finally, we calculate the emission of gravitational waves associated with deconfinement phase transitions, discuss the possibility of their detection, and how this would provide information about the equation of state of dense matter., Comment: Invited review for the International Journal of Modern Physics E
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- 2019
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62. Reaction time asymmetries provide insight into mechanisms underlying dominant and non-dominant hand selection
- Author
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Dexheimer, Brooke, Przybyla, Andrzej, Murphy, Terrence E., Akpinar, Selcuk, and Sainburg, Robert
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- 2022
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63. Brain Abnormalities in PIK3CA-Related Overgrowth Spectrum: Physician, Patient, and Caregiver Experiences
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Dexheimer, Joy and Mirzaa, Ghayda M.
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- 2022
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64. Hyperons and quarks in proto-neutron stars
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Roark, J., Du, X., Constantinou, C., Dexheimer, V., Steiner, A. W., and Stone, J. R.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
In this work, we study matter in the cores of proto-neutron stars, focusing on the impact of their composition on the stellar structure. We begin by examining the effects of finite temperature (through a fixed entropy per baryon) and lepton fraction on purely nucleonic matter by making use of the DSH model . We then turn our attention to a relativistic mean-field model containing exotic degrees of freedom, the Chiral Mean Field (CMF) model, again, under the conditions of finite temperature and trapped neutrinos. In the latter, since both hyperons and quarks are found in the cores of large-mass stars, their interplay and the possibility of mixtures of phases is taken into account and analyzed. Finally, we discuss how stellar rotation can affect our results.
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- 2018
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65. Can magnetic fields stabilize or destabilize twin stars?
- Author
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Gomes, R. O., Dexheimer, V., Han, S., and Schramm, S.
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Sharp phase transitions described by stiff equations of state allow for the existence of a third family of stable compact stars (besides white dwarfs and neutron stars), twin stars. In this work, we investigate for the first time the role of strong magnetic fields on non-magnetic twin stars sequences and the case in which magnetic fields themselves give rise to a third family of stable stars. We use three sets of equations of state to study such effects from a more general point of view: the Quark-Hadron Chiral Parity-Doublet (Q$\chi$P) model for both hadronic and quark phases, and the Many-Body Forces (MBF) model connected to either the MIT Bag model with vector interaction (MIT) or to the Constant-Sound-Speed (CSS) approximation for the quark phase, through a Maxwell construction. Magnetic field effects are introduced in the structure of stars through the solution of the Einstein-Maxwell equations, assuming a poloidal magnetic field configuration and a metric that allows for the description of deformed stars. We show that strong magnetic fields can destabilize twin star sequences, with the threshold intensity being model dependent. On the other hand, magnetic fields can also give rise to twin stars in models that did not predict these sequences, up to some point when they are again destabilized. In this sense, magnetic fields can play an important role on the evolution of neutron stars.
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- 2018
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66. What do we learn about vector interactions from GW170817?
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Dexheimer, Veronica, Gomes, Rosana de Oliveira, Schramm, Stefan, and Pais, Helena
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We analyze the role played by vector-isovector meson interaction in dense matter present in the interior of neutron stars in the light of new measurements made during the double neutron-star merger GW170817. These concern measurements of tidal deformability from gravitational waves and electromagnetic observations. Our study includes three different equations of state that contain different physical assumptions and matter compositions, namely the NL3 family, MBF, and CMF models. Other related quantities/relations analyzed are the neutron matter pressure, symmetry energy slope, stellar masses and radii, and Urca process threshold for stellar cooling.
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- 2018
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67. Signatures of quark-hadron phase transitions in general-relativistic neutron-star mergers
- Author
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Most, Elias R., Papenfort, L. Jens, Dexheimer, Veronica, Hanauske, Matthias, Schramm, Stefan, Stöcker, Horst, and Rezzolla, Luciano
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Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology ,Nuclear Theory - Abstract
Merging binaries of neutron stars are not only strong sources of gravitational waves, but also have the potential of revealing states of matter at densities and temperatures not accessible in laboratories. A crucial and long-standing question in this context is whether quarks are deconfined as a result of the dramatic increase in density and temperature following the merger. We present the first fully general-relativistic simulations of merging neutron stars including quarks at finite temperatures that can be switched off consistently in the equation of state. Within our approach, we can determine clearly what signatures a quark-hadron phase transition would leave in the gravitational-wave signal. In particular, we show that if the conditions are met for a phase transition to take place at several times nuclear saturation density, they would lead to a post-merger signal considerably different from the one expected from the inspiral, that can only probe the hadronic part of the equations of state, and to an anticipated collapse of the merged object. We also show that the phase transition leads to a very hot and dense quark core that, when it collapses to a black hole, produces a ringdown signal different from the hadronic one. Finally, in analogy with what is done in heavy-ion collisions, we use the evolution of the temperature and density in the merger remnant to illustrate the properties of the phase transition in a QCD phase diagram., Comment: Version accepted by PRL
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- 2018
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68. Modeling magnetic neutron stars: a short overview
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Gomes, R. O., Schramm, S., and Dexheimer, V.
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Astrophysics - High Energy Astrophysical Phenomena ,Nuclear Theory - Abstract
Neutron stars are the endpoint of the life of intermediate mass stars and posses in their cores matter in the most extreme conditions in the universe. Besides their extremes of temperature (found in proto-neutron stars) and densities, typical neutron star' magnetic fields can easily reach trillions of times higher the one of the Sun. Among these stars, about $10\%$ are denominated \emph{magnetars} which possess even stronger surface magnetic fields of up to $10^{15}-10^{16}\,\mathrm{G}$. In this conference proceeding, we present a short review of the history and current literature regarding the modeling of magnetic neutron stars. Our goal is to present the results regarding the introduction of magnetic fields in the equation of state of matter using Relativistic Mean Field models (RMF models) and in the solution of Einstein's equations coupled to the Maxwell's equations in order to generate a consistent calculation of magnetic stars structure. We discuss how equation of state modeling affects mass, radius, deformation, composition and magnetic field distribution in stars and also what are the open questions in this field of research., Comment: Poster presented at the XIV International Workshop on Hadron Physics, Florian\'opolis, Brazil, March 2018
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- 2018
69. Cooling of Small and Massive Hyperonic Stars
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Negreiros, Rodrigo, Tolos, Laura, Centelles, Mario, Ramos, Angels, and Dexheimer, Veronica
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Astrophysics - High Energy Astrophysical Phenomena ,Nuclear Theory - Abstract
We perform cooling simulations for isolated neutron stars using recently developed equations of state for their core. The equations of state are obtained from new parametrizations of the FSU2 relativistic mean-field functional that reproduce the properties of nuclear matter and finite nuclei, while fulfilling the restrictions on high-density matter deduced from heavy-ion collisions, measurements of massive 2$M_{\odot}$ neutron stars, and neutron star radii below 13 km. We find that two of the models studied, FSU2R (with nucleons) and in particular FSU2H (with nucleons and hyperons), show very good agreement with cooling observations, even without including extensive nucleon pairing. This suggests that the cooling observations are more compatible with an equation of state that produces a soft nuclear symmetry energy and, hence, generates small neutron star radii. However, both models favor large stellar masses, above $1.8 M_{\odot}$, to explain the colder isolated neutron stars that have been observed, even if nucleon pairing is present., Comment: 15 pages, 13 figures, 3 tables, accepted version in The Astrophysical Journal
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- 2018
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70. The Deconfinement Phase Transition in Proto-Neutron-Star Matter
- Author
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Roark, J. and Dexheimer, V.
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
In this work, we study in detail the deconfinement phase transition that takes place in hot/dense nuclear matter in the context of neutron stars and proto-neutron stars (in which lepton fraction is fixed). The possibility of different mixtures of phases with different locally and globally conserved quantities is considered in each case. For this purpose, the Chiral Mean Field (CMF) model, an effective relativistic model that includes self-consistent chiral symmetry restoration and deconfinement to quark matter, is employed. Finally, we compare our results with data provided by PQCD for different temperatures and conditions., Comment: version accepted to PRC
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- 2018
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71. EXAFS Spectroscopy of Fractional Mixed-Valence Charge Density Wave Systems
- Author
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Turner, NA, Kim, SS, Brozik, JA, Marcus, MA, Fakra, SC, and Dexheimer, SL
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Chemical Sciences ,Engineering ,Technology ,Physical Chemistry - Abstract
We present extended X-ray absorption fine structure (EXAFS) spectra and modeling of a series of structurally tunable quasi-one-dimensional mixed-valence platinum-halide linear chain materials, [Pt(en2)][Pt(en2)X2](ClO4)4 with X = Cl, Br, I. The materials exhibit a commensurate charge density wave with fractional charge states on alternating platinum ions in the chain, as well as a Peierls distortion with alternating platinum-halide bond lengths. The amplitude of the charge density wave and, correspondingly, the extent of the Peierls distortion are controlled by the identity of the bridging halide ion. We have carried out ab initio multiple scattering calculations using the FEFF9 code to relate the oriented Pt LIII EXAFS spectra to the tunable electronic and structural properties. The spectral modeling reveals distinct photoelectron threshold energy values for the two inequivalent platinum ions in each of the mixed-valence chains, with values that vary systematically with fractional valence state. The difference in the photoelectron threshold energies of the two inequivalent platinum ions within each material correlates directly with the amplitude of the charge density wave, reflecting the decrease in charge density wave strength through the halide series X = Cl, Br, and I. We use dynamical matrix modeling to relate the experimentally determined mean-square relative displacement parameters for the metal-halide bond distances to the chain-axis vibrational modes that modulate the charge density wave structure. In addition, we discuss the EXAFS fitting results for the Pt-I bond lengths in the [Pt(en2)][Pt(en2)I2](ClO4)4 complex in comparison to previous, mutually inconsistent structural determinations for this material.
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- 2019
72. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis
- Author
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Haberman, Yael, Schirmer, Melanie, Dexheimer, Phillip J, Karns, Rebekah, Braun, Tzipi, Kim, Mi-Ok, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Rosh, Joel, Markowitz, James, Crandall, Wallace V, Mack, David R, Griffiths, Anne M, Heyman, Melvin B, Baker, Susan S, Kellermayer, Richard, Moulton, Dedrick, Patel, Ashish S, Gulati, Ajay S, Steiner, Steven J, LeLeiko, Neal, Otley, Anthony, Oliva-Hemker, Maria, Ziring, David, Kirschner, Barbara S, Keljo, David J, Guthery, Stephen L, Cohen, Stanley A, Snapper, Scott, Evans, Jonathan, Dubinsky, Marla, Aronow, Bruce, Hyams, Jeffrey S, Kugathasan, Subra, Huttenhower, Curtis, Xavier, Ramnik J, and Denson, Lee A
- Subjects
Biomedical and Clinical Sciences ,Immunology ,Prevention ,Genetics ,Inflammatory Bowel Disease ,Clinical Research ,Digestive Diseases ,Pediatric ,Aetiology ,2.1 Biological and endogenous factors ,Adolescent ,Age Factors ,Aging ,Child ,Child ,Preschool ,Cohort Studies ,Crohn Disease ,Dysbiosis ,Female ,Gene Expression Regulation ,Humans ,Ileum ,Male ,Peyer's Patches ,Puberty ,Risk ,Th1 Cells ,alpha-Defensins ,Biological Sciences ,Medical and Health Sciences - Abstract
Age-of-diagnosis associated variation in disease location and antimicrobial sero-reactivity has suggested fundamental differences in pediatric Crohn Disease (CD) pathogenesis. This variation may be related to pubertal peak incidence of ileal involvement and Peyer's patches maturation, represented by IFNγ-expressing Th1 cells. However, direct mucosal evidence is lacking. We characterize the global pattern of ileal gene expression and microbial communities in 525 treatment-naive pediatric CD patients and controls (Ctl), stratifying samples by their age-of-diagnosis. We show a robust ileal gene signature notable for higher expression of specific immune genes including GM-CSF and INFγ, and reduced expression of antimicrobial Paneth cell α-defensins, in older compared to younger patients. Reduced α-defensin expression in older patients was associated with higher IFNγ expression. By comparison, the CD-associated ileal dysbiosis, characterized by expansion of Enterobacteriaceae and contraction of Lachnospiraceae and Ruminococcaceae, was already established within the younger group and did not vary systematically with increasing age-of-diagnosis. Multivariate analysis considering individual taxa, however did demonstrate negative associations between Lachnospiraceae and IFNγ, and positive associations between Bacteroides and α-defensin expression. These data provide evidence for maturation of mucosal Th1 immune responses and loss of epithelial antimicrobial α-defensins which are associated with specific taxa with increasing age-of-diagnosis in pediatric CD.
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- 2019
73. Phase Transitions in Dense and Hot Matter
- Author
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Dexheimer, Veronica
- Subjects
Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
In this conference proceeding, I discuss in detail the deconfinement to quark matter that takes place at large densities and/or temperatures. The first-order phase transition that is assumed to appear beyond a critical point gives rise to mixtures of phases when more than one globally conserved quantity (such as charge fraction) is imposed. The modifications caused by these mixtures of phases in the QCD phase diagram can have consequences on signals of the existence of quark matter expected to be created in heavy-ion collisions, as well as supernova explosions and neutron-star mergers., Comment: Prepared for Critical Point and Onset of Deconfinement - CPOD2017
- Published
- 2017
74. Anisotropy in the equation of state of strongly magnetized quark matter within the Nambu--Jona-Lasinio Model
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Avancini, Sidney S., Dexheimer, Veronica, Farias, Ricardo L. S., and Timóteo, Varese S.
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High Energy Physics - Phenomenology ,Astrophysics - High Energy Astrophysical Phenomena ,Nuclear Theory - Abstract
In this article, we calculate the magnetization and other thermodynamical quantities for strongly magnetized quark matter within the Nambu-Jona-Lasinio model at zero temperature. We assume two scenarios, chemically equilibrated charge neutral matter present in the interior of compact stars and zero-strangeness isospin-symmetric matter created in nuclear experiments. We show that the magnetization oscillates with density but in a much more smooth form than what was previously shown in the literature. As a consequence, we do not see the unphysical behavior in the pressure in the direction perpendicular to the magnetic field that was previously found. Finally, we also analyze the effects of a vector interaction on our results., Comment: 9 pages, 10 figures, replaced with version matching the one published in the Physical Review C
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- 2017
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75. The Magnetic Field Distribution in Strongly Magnetized Neutron Stars
- Author
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Dexheimer, V., Franzon, B., Gomes, R. O., Farias, R. L. S., Avancini, S. S., and Schramm, S.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
In this work, we expand on a previously reported realistic calculation of the magnetic field profile for the equation of state inside strongly magnetized neutron stars. In addition to showing that magnetic fields increase quadratically with increasing baryon chemical potential of magnetized matter (instead of exponentially, as previously assumed), we show here that the magnetic field increase with baryon number density is more complex and harder to model. We do so by the analysis of several different realistic models for the microscopic description of matter in the star (including hadronic, hybrid and quark models) combined with general relativistic solutions by solving Einstein-Maxwell's field equations in a self-consistent way for stars endowed with a poloidal magnetic field., Comment: Proceedings of the 4th Caribbean Symposium on Cosmology, Gravitation, Nuclear and Astroparticle Physics (STARS2017) and 5th International Symposium on Strong Electromagnetic Fields and Neutron Stars (SMFNS2017)
- Published
- 2017
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76. Many-body forces in magnetic neutron stars
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Gomes, R. O., Franzon, B., Dexheimer, V., and Schramm, S.
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Nuclear Theory - Abstract
In this work, we study in detail the effects of many-body forces on the equation of state and the structure of magnetic neutron stars. The stellar matter is described within a relativistic mean field formalism that takes into account many-body forces by means of a non-linear meson field dependence on the nuclear interaction coupling constants. We assume that matter is at zero temperature, charge neutral, in beta-equilibrium, and populated by the baryon octet, electrons, and muons. In order to study the effects of different degrees of stiffness in the equation of state, we explore the parameter space of the model, which reproduces nuclear matter properties at saturation, as well as massive neutron stars. Magnetic field effects are introduced both in the equation of state and in the macroscopic structure of stars by the self-consistent solution of the Einstein-Maxwell equations. In addition, effects of poloidal magnetic fields on the global properties of stars, as well as density and magnetic field profiles are investigated. We find that not only different macroscopic magnetic field distributions, but also different parameterizations of the model for a fixed magnetic field distribution impact the gravitational mass, deformation and internal density profiles of stars. Finally, we also show that strong magnetic fields affect significantly the particle populations of stars, Comment: accepted by The Astrophysical Journal
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- 2017
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77. Tabulated Neutron Star Equations of State Modeled within the Chiral Mean Field Model
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Dexheimer, V.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
In this special issue article, I review some of the accomplishments of the chiral mean field (CMF) model, which contains nucleon, hyperon, and quark degrees of freedom, and its applications to proto-neutron and neutron stars. I also present a set of equation of state and particle population tables built using the CMF model subject to physical constraints necessary to reproduce different environments, such as those present in cold neutron stars, core-collapse supernova explosions and different stages of compact star mergers., Comment: PASA special issue on the Neutron Stars, related to the Compstar conference in Warsaw
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- 2017
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78. The application of the Quark-Hadron Chiral Parity-Doublet Model to neutron star matter
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Mukherjee, A., Schramm, S., Steinheimer, J., and Dexheimer, V.
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Quark-Hadron Chiral Parity-Doublet model (Q$\chi$P) is applied to calculate compact star properties in the presence of a deconfinement phase transition. Within this model, a consistent description of nuclear matter properties, chiral symmetry restoration, and a transition from hadronic to quark and gluonic degrees of freedom is possible within one unified approach. We find that the equation of state obtained is consistent with recent perturbative quantum chromodynamics (QCD) results and is able to accommodate observational constraints of massive and small neutron stars. Furthermore, we show that important features of the equation of state, such as the symmetry energy and its slope, are well within their observational constraints., Comment: 8 pages, 9 figures and 1 table
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- 2017
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79. Phase transitions in dense matter
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Dexheimer, Veronica, Hempel, Matthias, Iosilevskiy, Igor, and Schramm, Stefan
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
As the density of matter increases, atomic nuclei disintegrate into nucleons and, eventually, the nucleons themselves disintegrate into quarks. The phase transitions (PT's) between these phases can vary from steep first order to smooth crossovers, depending on certain conditions. First-order PT's with more than one globally conserved charge, so-called non-congruent PT's, have characteristic differences compared to congruent PT's. In this conference proceeding we discuss the non-congruence of the quark deconfinement PT at high densities and/or temperatures relevant for heavy-ion collisions, neutron stars, proto-neutron stars, supernova explosions, and compact-star mergers., Comment: Proceedings of XXVIth International Conference on Ultrarelativistic Nucleus-Nucleus Collisions (Quark Matter 2017)
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- 2017
- Full Text
- View/download PDF
80. Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
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Haberman, Yael, Karns, Rebekah, Dexheimer, Phillip J, Schirmer, Melanie, Somekh, Judith, Jurickova, Ingrid, Braun, Tzipi, Novak, Elizabeth, Bauman, Laura, Collins, Margaret H, Mo, Angela, Rosen, Michael J, Bonkowski, Erin, Gotman, Nathan, Marquis, Alison, Nistel, Mason, Rufo, Paul A, Baker, Susan S, Sauer, Cary G, Markowitz, James, Pfefferkorn, Marian D, Rosh, Joel R, Boyle, Brendan M, Mack, David R, Baldassano, Robert N, Shah, Sapana, Leleiko, Neal S, Heyman, Melvin B, Grifiths, Anne M, Patel, Ashish S, Noe, Joshua D, Aronow, Bruce J, Kugathasan, Subra, Walters, Thomas D, Gibson, Greg, Thomas, Sonia Davis, Mollen, Kevin, Shen-Orr, Shai, Huttenhower, Curtis, Xavier, Ramnik J, Hyams, Jeffrey S, and Denson, Lee A
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Immunology ,Nutrition ,Inflammatory Bowel Disease ,Clinical Research ,Autoimmune Disease ,Digestive Diseases ,Genetics ,Biotechnology ,4.1 Discovery and preclinical testing of markers and technologies ,Aetiology ,2.1 Biological and endogenous factors ,Detection ,screening and diagnosis ,Oral and gastrointestinal ,Good Health and Well Being ,Adolescent ,Adult ,Anti-Inflammatory Agents ,Non-Steroidal ,Child ,Colitis ,Ulcerative ,Feces ,Female ,Gene Expression Profiling ,Genes ,Mitochondrial ,Glucocorticoids ,Humans ,Integrins ,Intestinal Mucosa ,Male ,Mesalamine ,Microbiota ,Mitochondria ,Mitochondrial Diseases ,Precision Medicine ,Prospective Studies ,Rectum ,Remission Induction ,Sequence Analysis ,RNA ,Severity of Illness Index ,Transcriptome ,Treatment Outcome ,Tumor Necrosis Factor-alpha - Abstract
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate our key findings in adult and paediatric UC cohorts of 408 participants. We observe a marked suppression of mitochondrial genes and function across cohorts in active UC, and that increasing disease severity is notable for enrichment of adenoma/adenocarcinoma and innate immune genes. A subset of severity genes improves prediction of corticosteroid-induced remission in the discovery cohort; this gene signature is also associated with response to anti-TNFα and anti-α4β7 integrin in adults. The severity and therapeutic response gene signatures were in turn associated with shifts in microbes previously implicated in mucosal homeostasis. Our data provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.
- Published
- 2019
81. Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis.
- Author
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Sherrill, Joseph D, Kc, Kiran, Wang, Xinjian, Wen, Ting, Chamberlin, Adam, Stucke, Emily M, Collins, Margaret H, Abonia, J Pablo, Peng, Yanyan, Wu, Qiang, Putnam, Philip E, Dexheimer, Phillip J, Aronow, Bruce J, Kottyan, Leah C, Kaufman, Kenneth M, Harley, John B, Huang, Taosheng, and Rothenberg, Marc E
- Subjects
T-Lymphocytes ,Mitochondria ,Fibroblasts ,Epithelial Cells ,Humans ,Ketoglutarate Dehydrogenase Complex ,Oxidoreductases ,Ketone Oxidoreductases ,Oxidoreductases Acting on CH-CH Group Donors ,Proteins ,RNA ,Small Interfering ,Interleukin-13 ,Cytokines ,Up-Regulation ,Mutation ,Adult ,Child ,Female ,Male ,Eosinophilic Esophagitis ,Exome Sequencing ,Allergy ,Cellular immune response ,Immunology ,Inflammation ,Human Genome ,Food Allergies ,Clinical Research ,Genetics ,Digestive Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Whole Exome Sequencing - Abstract
Eosinophilic esophagitis (EoE) is an allergic inflammatory esophageal disorder with a complex underlying genetic etiology often associated with other comorbidities. Using whole-exome sequencing (WES) of 63 patients with EoE and 60 unaffected family members and family-based trio analysis, we sought to uncover rare coding variants. WES analysis identified 5 rare, damaging variants in dehydrogenase E1 and transketolase domain-containing 1 (DHTKD1). Rare variant burden analysis revealed an overabundance of putative, potentially damaging DHTKD1 mutations in EoE (P = 0.01). Interestingly, we also identified 7 variants in the DHTKD1 homolog oxoglutarate dehydrogenase-like (OGDHL). Using shRNA-transduced esophageal epithelial cells and/or patient fibroblasts, we further showed that disruption of normal DHTKD1 or OGDHL expression blunts mitochondrial function. Finally, we demonstrated that the loss of DHTKD1 expression increased ROS production and induced the expression of viperin, a gene previously shown to be involved in production of Th2 cytokines in T cells. Viperin had increased expression in esophageal biopsies of EoE patients compared with control individuals and was upregulated by IL-13 in esophageal epithelial cells. These data identify a series of rare genetic variants implicating DHTKD1 and OGDHL in the genetic etiology of EoE and underscore a potential pathogenic role for mitochondrial dysfunction in EoE.
- Published
- 2018
82. Ipsilesional arm training in severe stroke to improve functional independence (IPSI): phase II protocol
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Maenza, Candice, Sainburg, Robert L., Varghese, Rini, Dexheimer, Brooke, Demers, Marika, Bishop, Lauri, Jayasinghe, Shanie A. L., Wagstaff, David A., and Winstein, Carolee
- Published
- 2022
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83. Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis
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Nayak, R. C., Chang, K. H., Singh, A. K., Kotliar, M., Desai, M., Wellendorf, A. M., Wunderlich, M., Bartram, J., Mizukawa, B., Cuadrado, M., Dexheimer, P., Barski, A., Bustelo, X. R., Nassar, N. N., and Cancelas, J. A.
- Published
- 2022
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84. Highly magnetized neutron stars in a many-body forces formalism
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Gomes, R. O., Franzon, B., Dexheimer, V., Schramm, S., and Vasconcellos, C. A. Z.
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Nuclear Theory ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
In this work, we study the effects of different magnetic field configurations in neutron stars described by a many-body forces formalism (MBF model). The MBF model is a relativistic mean field formalism that takes into account many-body forces by means of a meson field dependence of the nuclear interaction coupling constants. We choose the best parametrization of the model that reproduces nuclear matter properties at saturation and also describes massive neutron stars. We assume matter to be in beta-equilibrium, charge neutral and at zero temperature. Magnetic fields are taken into account both in the equation of state and in the structure of the stars by the self-consistent solution of the Einstein-Maxwell equations. We assume a poloidal magnetic field distribution and calculate its effects on neutron stars, showing its influence on the gravitational mass and deformation of the stars., Comment: Contribution to the Proceedings of the VII International Workshop on Astronomy and Relativistic Astrophysics - IWARA 2016
- Published
- 2017
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85. The population of highly magnetized neutron stars
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Gomes, R. O., Dexheimer, V., Franzon, B., and Schramm, S.
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Nuclear Theory ,Astrophysics - Solar and Stellar Astrophysics - Abstract
In this work, we study the effects of strong magnetic field configurations on the population of neutron stars. The stellar matter is described within a relativistic mean field formalism which considers many-body force contributions in the scalar couplings. We choose the parametrization of the model that reproduces nuclear matter properties at saturation and also describes massive hyperon stars. Hadronic matter is modeled at zero temperature, in beta-equilibrium, charge neutral and populated by the baryonic octet, electrons and muons. Magnetic effects are taken into account in the structure of stars by the solution of the Einstein-Maxwell equations with the assumption of a poloidal magnetic field distribution. Our results show that magnetic neutron stars are populated essencialy by nucleons and leptons, due to the fact that strong magnetic fields decrease the central density of stars and, hence, supress the appearance of exotic particles., Comment: Prepared for Conference "Compact Stars in the QCD phase diagram V" 23-27 May 2016 GSSI and LNGS (L'Aquila, Italy)
- Published
- 2017
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86. A self-consistent study of magnetic field effects on hybrid stars
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Dexheimer, V., Franzon, B., and Schramm, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
It is understood that strong magnetic fields affect the structure of neutron stars. Nevertheless, many calculations for magnetized neutron stars are still being performed using symmetric solutions of Einstein's equations. In this conference proceeding, we review why this is not the correct procedure and we also discuss the effects of magnetic fields on the stellar population and temperature profiles., Comment: Prepared for Conference "Compact Stars in the QCD phase diagram V" 23-27 May 2016 GSSI and LNGS (L'Aquila, Italy)
- Published
- 2017
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- View/download PDF
87. What is the magnetic field distribution for the equation of state of magnetized neutron stars?
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Dexheimer, V., Franzon, B., Gomes, R. O., Farias, R. L. S., Avancini, S. S., and Schramm, S.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,General Relativity and Quantum Cosmology ,Nuclear Theory - Abstract
In this Letter, we report a realistic calculation of the magnetic field profile for the equation of state inside strongly magnetized neutron stars. Unlike previous estimates, which are widely used in the literature, we find that magnetic fields increase relatively slowly with increasing baryon chemical potential (or baryon density) of magnetized matter. More precisely, the increase is polynomial instead of exponential, as previously assumed. Through the analysis of several different realistic models for the microscopic description of stellar matter (including hadronic, hybrid and quark models) combined with general relativistic solutions endowed with a poloidal magnetic field obtained by solving Einstein-Maxwell's field equations in a self-consistent way, we generate a phenomenological fit for the magnetic field distribution in the stellar polar direction to be used as input in microscopic calculations.
- Published
- 2016
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- View/download PDF
88. The internal composition of proto-neutron stars under strong magnetic fields
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Franzon, B., Dexheimer, V., and Schramm, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Nuclear Theory - Abstract
In this work, we study the effects of magnetic fields and rotation on the structure and composition of proto-neutron stars (PNS's). A hadronic chiral SU(3) model is applied to cold neutron stars (NS) and proto-neutron stars with trapped neutrinos and at fixed entropy per baryon. We obtain general relativistic solutions for neutron and proto-neutron stars endowed with a poloidal magnetic field by solving Einstein-Maxwell field equations in a self-consistent way. As the neutrino chemical potential decreases in value over time, this alters the chemical equilibrium and the composition inside the star, leading to a change in the structure and in the particle population of these objects. We find that the magnetic field deforms the star and significantly alters the number of trapped neutrinos in the stellar interior, together with strangeness content and temperature in each evolution stage., Comment: Accepted for publication in PRD
- Published
- 2016
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89. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease.
- Author
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Haberman, Yael, BenShoshan, Marina, Di Segni, Ayelet, Dexheimer, Phillip J, Braun, Tzipi, Weiss, Batia, Walters, Thomas D, Baldassano, Robert N, Noe, Joshua D, Markowitz, James, Rosh, Joel, Heyman, Melvin B, Griffiths, Anne M, Crandall, Wallace V, Mack, David R, Baker, Susan S, Kellermayer, Richard, Patel, Ashish, Otley, Anthony, Steiner, Steven J, Gulati, Ajay S, Guthery, Stephen L, LeLeiko, Neal, Moulton, Dedrick, Kirschner, Barbara S, Snapper, Scott, Avivi, Camila, Barshack, Iris, Oliva-Hemker, Maria, Cohen, Stanley A, Keljo, David J, Ziring, David, Anikster, Yair, Aronow, Bruce, Hyams, Jeffrey S, Kugathasan, Subra, and Denson, Lee A
- Subjects
Biotechnology ,Autoimmune Disease ,Prevention ,Crohn's Disease ,Inflammatory Bowel Disease ,Digestive Diseases ,Genetics ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Adolescent ,Caco-2 Cells ,Child ,Crohn Disease ,Down-Regulation ,Female ,Gene Expression Profiling ,Gene Expression Regulation ,Neoplastic ,Gene Regulatory Networks ,Hepatocyte Nuclear Factor 4 ,Humans ,Ileum ,Male ,Oligonucleotide Array Sequence Analysis ,RNA ,Long Noncoding ,RNA ,Messenger ,Up-Regulation ,Crohn disease ,long ncRNA ,RNAseq ,RNA expression ,Clinical Sciences ,Gastroenterology & Hepatology - Abstract
BackgroundLong noncoding RNAs (lncRNA) are key regulators of gene transcription and many show tissue-specific expression. We previously defined a novel inflammatory and metabolic ileal gene signature in treatment-naive pediatric Crohn disease (CD). We now extend our analyses to include potential regulatory lncRNA.MethodsUsing RNAseq, we systematically profiled lncRNAs and protein-coding gene expression in 177 ileal biopsies. Co-expression analysis was used to identify functions and tissue-specific expression. RNA in situ hybridization was used to validate expression. Real-time polymerase chain reaction was used to test lncRNA regulation by IL-1β in Caco-2 enterocytes.ResultsWe characterize widespread dysregulation of 459 lncRNAs in the ileum of CD patients. Using only the lncRNA in discovery and independent validation cohorts showed patient classification as accurate as the protein-coding genes, linking lncRNA to CD pathogenesis. Co-expression and functional annotation enrichment analyses across several tissues and cell types 1showed that the upregulated LINC01272 is associated with a myeloid pro-inflammatory signature, whereas the downregulated HNF4A-AS1 exhibits association with an epithelial metabolic signature. We confirmed tissue-specific expression in biopsies using in situ hybridization, and validated regulation of prioritized lncRNA upon IL-1β exposure in differentiated Caco-2 cells. Finally, we identified significant correlations between LINC01272 and HNF4A-AS1 expression and more severe mucosal injury.ConclusionsWe systematically define differentially expressed lncRNA in the ileum of newly diagnosed pediatric CD. We show lncRNA utility to correctly classify disease or healthy states and demonstrate their regulation in response to an inflammatory signal. These lncRNAs, after mechanistic exploration, may serve as potential new tissue-specific targets for RNA-based interventions.
- Published
- 2018
90. CompOSE reference manual: Version 3.01, CompStar Online Supernovæ Equations of State, “harmonising the concert of nuclear physics and astrophysics”, https://compose.obspm.fr
- Author
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Typel, S., Oertel, M., Klähn, T., Chatterjee, D., Dexheimer, V., Ishizuka, C., Mancini, M., Novak, J., Pais, H., Providência, C., R. Raduta, Ad., Servillat, M., and Tolos, L.
- Published
- 2022
- Full Text
- View/download PDF
91. Noncongruence of phase transitions in strongly interacting matter
- Author
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Hempel, Matthias, Dexheimer, Veronica, Schramm, Stefan, and Iosilevskiy, Igor
- Subjects
Nuclear Theory - Abstract
First-order phase transitions (PTs) with more than one globally conserved charge, so-called noncongruent PTs, have characteristic differences compared to congruent PTs (e.g., dimensionality of phase diagrams and location of critical points and endpoints). Here we discuss the noncongruent features of the QCD PT and compare it with the nuclear liquid-gas (LG) PT, for symmetric and asymmetric matter in heavy-ion collisions and neutron stars. In addition, we have identified a principle difference between the LG and the QCD PT: they have opposite slopes in the pressure-temperature plane., Comment: 7 pages, 2 figures, Proceeding of the 14th Marcel Grossmann Meeting 2015
- Published
- 2015
92. A self-consistent study of magnetic field effects on hybrid stars
- Author
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Franzon, B., Dexheimer, V., and Schramm, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
In this work we study the effects of strong magnetic fields on hybrid stars by using a full general-relativity approach, solving the coupled Maxwell-Einstein equation in a self-consistent way. The magnetic field is assumed to be axi-symmetric and poloidal. We take into consideration the anisotropy of the energy-momentum tensor due to the magnetic field, magnetic field effects on equation of state, the interaction between matter and the magnetic field (magnetization), and the anomalous magnetic moment of the hadrons. The equation of state used is an extended hadronic and quark SU(3) non-linear realization of the sigma model that describes magnetized hybrid stars containing nucleons, hyperons and quarks. According to our results, the effects of the magnetization and the magnetic field on the EoS do not play an important role on global properties of these stars. On the other hand, the magnetic field causes the central density in these objects to be reduced, inducing major changes in the populated degrees of freedom and, potentially, converting a hybrid star into a hadronic star.
- Published
- 2015
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93. Modelling Hybrid Stars in Quark-Hadron Approaches
- Author
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Schramm, S., Dexheimer, V., and Negreiros, R.
- Subjects
Nuclear Theory - Abstract
The density in the core of neutron stars can reach values of about 5 to 10 times nuclear matter saturation density. It is, therefore, a natural assumption that hadrons may have dissolved into quarks under such conditions, forming a hybrid star. This star will have an outer region of hadronic matter and a core of quark matter or even a mixed state of hadrons and quarks. In order to investigate such phases, we discuss different model approaches that can be used in the study of compact stars as well as being applicable to a wider range of temperatures and densities. One major model ingredient, the role of quark interactions in the stability of massive hybrid stars is discussed. In this context, possible conflicts with lattice QCD simulations are investigated., Comment: Contribution to the EPJA Topical Issue on "Exotic Matter in Neutron Stars"
- Published
- 2015
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- View/download PDF
94. Many-body forces, isospin asymmetry and dense hyperonic matter
- Author
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Gomes, R. O., Dexheimer, V., Schramm, S., and Vascconcellos, C. A. Z.
- Subjects
Nuclear Theory ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The equation of state (EoS) of asymmetric nuclear matter at high densities is a key topic for the description of matter inside neutron stars. The determination of the properties of asymmetric nuclear matter, such as the symmetry energy ($a_{sym}$) and the slope of the symmetry energy ($L_0$) at saturation density, has been exaustively studied in order to better constrain the nuclear matter EoS. However, differently from symmetric matter properties that are reasonably constrained, the symmetry energy and its slope still large uncertainties in their experimental values. Regarding this subject, some studies point towards small values of the slope of the symmetry energy, while others suggest rather higher values. Such a lack of agreement raised a certain debate in the scientific community. In this paper, we aim to analyse the role of these properties on the behavior of asymmetric hyperonic matter. Using the formalism presented in Ref. (R.O. Gomes et al 2014}, which considers many-body forces contributions in the meson-baryon coupling, we calculate the EoS of asymmetric hyperonic matter and apply it to describe hyperonic matter and hyperon stars., Comment: 7 pages, contribution to Proceedings of the workshop "Compact Stars in the QCD phase diagram IV", Prerow, Germany, September 26 - 30, 2014
- Published
- 2015
95. Exotic Phases in Magnetars
- Author
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Schramm, S., Bhattacharyya, A., Dexheimer, V., and Mallick, R.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
Neutron stars feature extremely high magnetic fields with deduced field strengths of $10^{15}$ G in the case of magnetars and potentially much higher values inside of the star. In this context we consider the appearance of $\rho^-$ meson condensation taking into account the effect of the magnetic field. The results show that, depending on parameters, such a condensation in magnetized neutron stars might (just) occur., Comment: Contribution to the Proceedings of CSQCD IV, Prerow (2014)
- Published
- 2015
96. Reconciling Nuclear and Astrophysical Constraints
- Author
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Dexheimer, V., Negreiros, R., and Schramm, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
In view of new constraints put forth by recent observations and measurements in the realm of astrophysics and nuclear physics, we update the non-linear realization of the sigma model as to reflect such constraints. By doing this, we obtain new equations of state that may be used to describe neutron stars. Such equations of state are obtained by investigating different ways by which the vector mesons self-interact. Furthermore, we also investigate the role played by the delta mesons in the model. As a result, we are able to develop equations of state that are in better agreement with data, such as nuclear compressibility and slope of the symmetry energy at saturation, star masses, radii, and cooling profiles.
- Published
- 2015
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- View/download PDF
97. Lung ultrasound score and diaphragm ultrasound in weaning from mechanical ventilation: are they different in patients with and without COVID-19?
- Author
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Cordeiro Madeira, Laura, de Tarso Dalcin, Paulo, Heinen Schuster, Gabriele, Conte, Bruna, Michel Wolf, Jonas, Schreiber, Annia, Rouby, Jean-Jacques, and Leopoldo Dexheimer-Neto, Felippe
- Subjects
COVID-19 ,VENTILATOR weaning ,INTUBATION ,MEDICAL logic ,ULTRASONIC imaging ,ARTIFICIAL respiration - Abstract
Objective: To compare pre-extubation physiological characteristics and ultrasound variables between patients intubated for COVID-19 compared to a clinical population and those intubated for other reasons. Methods: This was a secondary analysis of a prospective cohort study of patients undergoing invasive mechanical ventilation (IMV) for more than 48 h. Patients were divided into two groups: those intubated for COVID19-induced ARDS and those intubated for other clinical reasons. Ultrasound assessment of lung and diaphragm function was performed before extubation. The results were compared between the two groups of patients. Results: In comparison with the patients without COVID-19, those with the disease were younger (a median age of 58 [46-76] years vs. a median age of 75 [69-85] years; p = 0.01), had fewer comorbidities (a median Charlson Comorbidity Index of 2 [1-4] vs. a median Charlson Comorbidity Index of 5 [4-6]; p < 0.01), and were less severely ill at admission (a median APACHE II score of 9 [8-14] vs. a median APACHE II score of 18 [13-22]; p < 0.01). In addition, the median duration of IMV was longer in the COVID-19 patients (11 [9-23] days vs. 6 [3-8] days; p < 0.01). Although extubation success rates were similar between the COVID-19 and non-COVID-19 groups (22 [71%] vs. 35 [77.8%]), median lung ultrasound score differed between the two groups (23 [18-25] vs. 15 [11-18]; p < 0.01), as did median diaphragmatic excursion (2.1 [1.7-2.4] vs. 1.7 [1.2-2.0]; p < 0.01). Conclusions: Although patients with COVID-19 requiring ventilatory support are younger and have fewer comorbidities than those intubated for other clinical reasons, they experience longer hospital stays. Although lung ultrasound score can differ between patients with and without COVID-19, these differences do not significantly translate into extubation success rates. Therefore, the utility of ultrasound scores in weaning COVID-19 patients from IMV needs further study. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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98. Will they participate? Predicting patients’ response to clinical trial invitations in a pediatric emergency department
- Author
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Ni, Yizhao, Beck, Andrew F, Taylor, Regina, Dyas, Jenna, Solti, Imre, Grupp-Phelan, Jacqueline, and Dexheimer, Judith W
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Pediatric ,Clinical Trials and Supportive Activities ,8.4 Research design and methodologies (health services) ,Health and social care services research ,Good Health and Well Being ,Algorithms ,Child ,Clinical Trials as Topic ,Emergency Service ,Hospital ,Female ,Hospitals ,Pediatric ,Humans ,Machine Learning ,Male ,Patient Acceptance of Health Care ,Patient Participation ,machine learning ,patient-directed precision recruitment ,predictive modeling ,socioeconomic status ,Information and Computing Sciences ,Engineering ,Medical and Health Sciences ,Medical Informatics ,Biomedical and clinical sciences ,Health sciences ,Information and computing sciences - Abstract
Objective(1) To develop an automated algorithm to predict a patient's response (ie, if the patient agrees or declines) before he/she is approached for a clinical trial invitation; (2) to assess the algorithm performance and the predictors on real-world patient recruitment data for a diverse set of clinical trials in a pediatric emergency department; and (3) to identify directions for future studies in predicting patients' participation response.Materials and methodsWe collected 3345 patients' response to trial invitations on 18 clinical trials at one center that were actively enrolling patients between January 1, 2010 and December 31, 2012. In parallel, we retrospectively extracted demographic, socioeconomic, and clinical predictors from multiple sources to represent the patients' profiles. Leveraging machine learning methodology, the automated algorithms predicted participation response for individual patients and identified influential features associated with their decision-making. The performance was validated on the collection of actual patient response, where precision, recall, F-measure, and area under the ROC curve were assessed.ResultsCompared to the random response predictor that simulated the current practice, the machine learning algorithms achieved significantly better performance (Precision/Recall/F-measure/area under the ROC curve: 70.82%/92.02%/80.04%/72.78% on 10-fold cross validation and 71.52%/92.68%/80.74%/75.74% on the test set). By analyzing the significant features output by the algorithms, the study confirmed several literature findings and identified challenges that could be mitigated to optimize recruitment.ConclusionBy exploiting predictive variables from multiple sources, we demonstrated that machine learning algorithms have great potential in improving the effectiveness of the recruitment process by automatically predicting patients' participation response to trial invitations.
- Published
- 2016
99. Many-body forces in the equation of state of hyperonic matter
- Author
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Gomes, R. O., Dexheimer, V., Schramm, S., and Vasconcellos, C. A. Z.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
In this work we introduce an extended version of the formalism proposed originally by Taurines et al. that considers the effects of many-body forces simulated by non-linear self-couplings and meson-meson interaction contributions. In this extended version of the model, we assume that matter is at zero temperature, charge neutral and in beta-equilibrium, considering that the baryon octet interacts by the exchange of scalar-isoscalar ($\sigma$,$\,\sigma^*$), vector-isoscalar ($\omega$,$\,\phi$), vector-isovector ($\varrho$) and scalar-isovector ($\delta$) meson fields. Using nuclear matter properties, we constrain the parameters of the model that describe the intensity of the indirectly density dependent baryon-meson couplings to a small range of possible values. We then investigate asymmetric hyperonic matter properties. We report that the formalism developed in this work is in agreement with experimental data and also allows for the existence of massive hyperon stars (with more than $2M_{\odot}$) with small radii, compatible with astrophysical observations.
- Published
- 2014
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- View/download PDF
100. The role of strangeness in hybrid stars and possible observables
- Author
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Dexheimer, V., Negreiros, R., and Schramm, S.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics ,Nuclear Theory - Abstract
We study the effects of strangeness on the quark sector of a hybrid star equation of state. Since the model we use to describe quarks is the same as the one we use to describe hadrons, we can also study the effects of strangeness on the chiral symmetry restoration and deconfinement phase transitions (first order or crossover). Finally, we analyze combined effects of hyperons and quarks on global properties of hybrid stars, like mass, radius and cooling profiles. It is found that a large amount of strangeness in the core is related to the generation of twin-star solutions, which can have the same mass as the lower or zero strangeness counterpart, but with smaller radii.
- Published
- 2014
- Full Text
- View/download PDF
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