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Over the past few years, there has been a surge of interest in the chemistry of bicyclobutanes (BCBs). Although BCBs have been used to synthesize bicyclo[2.1.1]hexanes and bicyclo[3.1.1]heptanes, the synthesis of bicyclo[4.1.1]octanes has remained elusive. Herein, we report the first Lewis acid-catalyzed unexpected (4+3) annulation of para-quinonemethides (p-QMs) with BCBs allowing the synthesis of oxabicyclo[4.1.1]octanes proceeding under mild conditions. With 5 mol % of Bi(OTf) 3 , the reaction afforded the (4+3) annulated product in high regioselectivity and good functional group compatibility via a simultaneous Lewis acid activation of BCBs and p-QMs. The reaction is likely initiated by the 1,6-addition of Lewis acid activated BCBs to p-QMs followed by the C2-selective intramolecular addition of the phenol moiety to the generated cyclobutyl cation intermediate. Moreover, detailed mechanistic studies provided insight into the mechanism of the reaction., (© 2024 Wiley-VCH GmbH.)

Timely diagnosis and management of pediatric acute liver failure (PALF) is of paramount importance to improve survival. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition invited national and international experts to identify and review important management and research questions. These covered the definition, age appropriate stepwise workup for the etiology, non-invasive diagnosis and management of cerebral edema, prognostic scores, criteria for listing for liver transplantation (LT) and bridging therapies in PALF. Statements and recommendations based on evidences assessed using the modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) system were developed, deliberated and critically reappraised by circulation. The final consensus recommendations along with relevant published background information are presented here. We expect that these recommendations would be followed by the pediatric and adult medical fraternity to improve the outcomes of PALF patients., (© 2024. Asian Pacific Association for the Study of the Liver.)

Strain-release driven annulations with bicyclo[1.1.0]butanes (BCBs) have become an attractive area of research for the synthesis of bioisosteric bicyclohexane derivatives, which play a vital role in drug discovery. Interestingly, the utilization of the inherent strain in BCBs for the synthesis of functionalized amino-bicyclo[2.1.1]hexenes, which may spatially mimic substituted benzenes and anilines, has received only scant attention. Herein, we report the Sc(OTf) 3 -catalyzed (3 + 2) annulation of BCBs with ynamides for the facile synthesis of 2-amino-bicyclo[2.1.1]hexenes in one step under mild conditions. The reaction likely proceeds via nucleophilic addition facilitated by the nitrogen lone pair from the alkynyl group of the ynamides to the unsubstituted side of the BCBs, followed by the annulation of the resulting enolate with the keteniminium species. For the first time, the C-C triple bond of ynamides was utilized as the coupling partner for BCBs, resulting in products adorned with a functionalizable amino group and an integrated strained alkene moiety., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Bicyclo[1.1.0]butanes (BCBs), featuring two fused cyclopropane rings, have found widespread application in organic synthesis. Their versatile reactivity towards radicals, nucleophiles, cations, and carbenes makes them suitable for various reactions, including ring-opening and annulation strategies. Despite this versatility, their potential as enophiles in an ene reaction remains underexplored. Considering this and given the challenges of achieving diastereoselectivity in ring-opening reactions of BCBs, herein, we present a unique method utilizing BCBs as enophiles in a mild and diastereoselective Sc(OTf) 3 -catalyzed formal ene reaction with thioindolinones/thiolactams, delivering 1,3-disubstituted cyclobutane derivatives in high yields and excellent regio- and diastereoselectivity. Notably, structurally different thiolactam derivatives underwent diastereoselective addition to BCBs, affording the corresponding cyclobutanes. The synthesized thioindole-substituted cyclobutanes could serve as a versatile tool for subsequent functional group manipulations., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

A biopsy-proven patient with prostate carcinoma aged 70 years was referred to the department of nuclear medicine for radionuclide-based therapy. His prostate-specific antigen levels were >1000 ng/mL, and prostatic magnetic resonance imaging showed an enlarged prostate with a heterogeneous signal and size 3.8x3.7x3.5 cm with few small heterogeneous nodular signals in the transition zone. He was scheduled for 18 F prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) scan before therapy. 18 F PSMA PET/CT revealed PSMA-expressing prostate lesions (maximum standardized uptake value ~10.2) with extension into the urinary bladder along with bilateral supraclavicular, mediastinal, retrocrural, retroperitoneal, and pelvic lymph nodes and sclerotic lesions in the entire axial and appendicular skeleton., Competing Interests: Conflict of Interest: No conflicts of interest were declared by the authors., (Copyright© 2024 The Author. Published by Galenos Publishing House on behalf of the Turkish Society of Nuclear Medicine.)

Background: Pediatric inflammatory bowel disease (IBD) has been known to be a disease predominant in the west. There is scarcity of data on pediatric IBD (P-IBD) from northern India. The objective of our study was to analyze the clinical spectrum of P-IBD in northern India., Methods: A retrospective analysis of 126 children (<18-year old) diagnosed with IBD from January 1999 to December 2019 was done on a pre-designed proforma. It was systematically entered in a MS Excel spreadsheet and analyzed using Statistical Package for the Social Sciences (SPSS) version 21.0. The descriptive phenotypes of Ulcerative colitis (UC) and Crohn's disease (CD) were revised according to the Paris classification., Results: Of 126 children, UC was diagnosed in 76 (60.3%), CD in 44 (34.9%) and IBD-unclassified (IBD-U) in six (4.76%) patients. The mean age at diagnosis was 11.3 years; 38.8% were < 10 years with the male: female ratio of 1.6:1. Sixteen children (12.7%) had very early onset IBD (VEOBD). Overall, the median time to diagnosis in IBD was 12 months (interquartile range [IQR]: 3.25-24), which was as high as 52.5 months (IQR: 11-98) in CD. Pancolitis with bleeding per rectum and ileocolonic involvement with pain in abdomen were the commonest presentations in UC and CD, respectively. Stricturing disease was seen in 27% of CD cases. Relapses were seen in 46% (35/76) of U.C and 23% (10/44) of CD kids. Step-up treatment protocol was employed in them with the use of biologicals in 12% of cases. There was a 2.75-fold rise in the IBD cases in the last 10 years (2010-20). There was reduction in time to diagnosis (21 months vs. 90 months; p - 0.012) and empirical anti-tubercular therapy use (90% vs. 5.8%) in CD over two decades., Conclusion: From our experience in a tertiary care centre in northern India, P-IBD is on the rise. UC is more common than CD. Pancolitis and ileocolonic disease are the commonest disease sites in UC and CD, respectively There is a significant delay in the time to diagnosis in CD. Stricturing disease was seen in a quarter of children with CD., (© 2023. Indian Society of Gastroenterology.)

Cyclophosphazenes offer a robust and easily modifiable platform for a diverse range of functional systems that have found applications in a wide variety of areas. Herein, for the first time, it reports an organophosphazene-based supramolecular ferroelectric [(PhCH 2 NH) 6 P 3 N 3 Me]I, [PMe]I. The compound crystallizes in the polar space group Pc and its thin-film sample exhibits remnant polarization of 5 µC cm -2 . Vector piezoresponse force microscopy (PFM) measurements indicated the presence of multiaxial polarization. Subsequently, flexible composites of [PMe]I are fabricated for piezoelectric energy harvesting applications using thermoplastic polyurethane (TPU) as the matrix. The highest open-circuit voltages of 13.7 V and the maximum power density of 34.60 µW cm -2 are recorded for the poled 20 wt.% [PMe]I/TPU device. To understand the molecular origins of the high performance of [PMe]I-based mechanical energy harvesting devices, piezoelectric charge tensor values are obtained from DFT calculations of the single crystal structure. These indicate that the mechanical stress-induced distortions in the [PMe]I crystals are facilitated by the high flexibility of the layered supramolecular assembly., (© 2023 The Authors. Small published by Wiley-VCH GmbH.)

Nitrogen pollution in water bodies has become a pressing environmental and public health issue worldwide, demanding the implementation of effective nitrogen removal strategies. This research paper delves into the performance evaluation of hybrid constructed wetlands (HCWs) as a sustainable and innovative approach for nitrogen removal, employing a comprehensive year-long dataset gathered from a practical setup. The study collected data under diverse operating conditions to investigate the effectiveness of HCWs in removing nitrogen. Results revealed that HCWs achieved nitrogen removal efficiencies ranging from 28% to 65%, influenced by temperature and hydraulic retention time. Optimal removal occurred at an average temperature of 28°C and a 4-day hydraulic retention time. Notably, performance declined during colder periods, with temperatures below 15°C. The study also aims to predict nitrogen removal by three modeling techniques, that is, artificial neural networks (ANNs), support vector machines Pearson VII kernel function (SVM PUK), and multiple linear regression (MLR). Prediction has been done considering temperature (TEMP), hydraulic loading rate (HLR), initial concentration of chemical oxygen demand (COD) (CODin), initial concentration of total nitrogen (TN in ), initial concentration of total phosphorous (TP in ), and initial concentration of turbidity (TB in ) as input parameters, whereas reduction of total nitrogen (RED TN) is regarded as output parameter. The performance of the soft computing techniques has been compared in terms of coefficient of determination (R 2 ), root mean square error (RMSE), and mean absolute error (MAE). The analysis revealed that the performance of the SVM (PUK) model (R 2 : 0.572, RMSE: 0.0359, MAE: 0.0294) for the prediction of TN reduction is superior followed by MLR (R 2 : 0.562, RMSE: 0.0365, MAE: 0.0294) and ANN (R 2 : 0.597, RMSE: 0.0377, MAE: 0.0301). The present study concludes that the treated effluent by the HCWs, using water hyacinth and water lettuce, is of fair quality, thus having potential application for the treatment of rice mill wastewater in warmer climates. Further, machine learning approaches employed in estimating the total nitrogen reduction by HCWs technology have shown promising applicability and utilization in such studies. PRACTITIONER POINTS: Hybrid constructed wetlands (HCWs) are effective in removing nitrogen from wastewater. The performance of HCWs in nitrogen removal can vary due to physical, chemical, and biological processes. The performance of the HCWs highly depends on temperature and hydraulic retention time. Artificial neural networks (ANNs) and support vector machines (SVMs) provided better predictions of nitrogen removal with high accuracy and low root mean square error., (© 2023 Water Environment Federation.)

Decentralised wastewater treatment systems, such as constructed wetlands, are becoming increasingly popular these days because they are more economical and cost-effective than conventional plants. The primary objective of this review paper is to determine the number of studies that have been conducted on constructed wetlands, specifically 'free water surface flow constructed wetlands', 'horizontal subsurface flow constructed wetlands', 'vertical subsurface flow constructed wetlands', and 'hybrid constructed wetlands'. In addition, the paper examines the status of research publications on constructed wetlands by country, author, and journal. Based on the review, it has been found that although constructed wetland technology is economical and cost-effective, it is still not among the top 10 effluent treatment methods. Compared to other constructed wetland systems, 'hybrid constructed wetlands' have received minimal attention. Based on the search results, 4639 documents published between 1989 and 2021 have been extracted from the online edition of SCI-EXPANDED, Web of Science. The documents associated with constructed wetlands are divided into eight main document types. Articles and proceedings papers are the most common document type, accounting for 93% of all publications, followed by reviews (4%), meeting abstracts (1.3%), corrections (0.56%), editorial materials (0.38%), news items (0.2%), letters (0.04%), and book reviews (0.02%)., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

This article aimed to estimate the local underground water associations, which will, in turn, be applied to discuss the location of each underground water cluster in the flow system. Additionally, this investigation intended to evaluate underground water's aptness from aquifers of the study area for domestic agricultural activities and the prime sources of alteration in the water chemistry. Geographically, the region does not have the privilege of the river (except the Yamuna in the eastern part) running through it and thus, has to rely heavily on groundwater. Therefore, it is necessary to study the groundwater characteristics in this region. This investigation manifested two sub-surface water associations (groups) showing two prime underground water types in the study area: the calcium-magnesium-bicarbonate water-types, groups (clusters) 1 member; and the sodium-bicarbonate-chloride water-types consisting of Group 2 members during post-monsoon and pre-monsoon periods. Group 1 is typical of underground water in recharge regions of the underground water flow system. It is the cleanest underground water type in part except for a few groundwater samples. The highest mean salinity was vested in group 2, the signature of underground waters in discharge regions of the underground water flow system. This investigation observes that three principal elements controlled the hydro-chemistry of underground water in the study area: chemical fertilizers from farms, carbonate mineral weathering, calcite, fluorite, silicate minerals, and exchange of cations in the region. All the underground water groups had high sodium (Na) concentrations and will cause the Na-hazard when applied for agricultural activities. Most samples of groups 1 and 2 were within the class II and I area of Doneen's plot during both periods and were therefore acceptable for agricultural activities in the investigation region., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)

The thyroid cartilage metastatic involvement is an extremely rare entity. It can be asymptomatic at the earlier stage and can become symptomatic later on. Involvement of thyroid cartilage is frequent in melanoma and renal and rarely reported in an advanced stage of carcinoma prostate, breast, and lung. These cases were usually reported on positron emission tomography/computed tomography (PET/CT) as can often easily be missed on computed tomography scan alone. We present a case report of metastatic involvement of thyroid cartilage in squamous cell carcinoma of buccal mucosa detected on the whole-body 18F-fluorodeoxyglucose PET/CT., Competing Interests: There are no conflicts of interest., (Copyright: © 2023 Indian Journal of Nuclear Medicine.)

The use of benzotriazoles as nucleophilic triggers in the three-component Yb(OTf) 3 -catalyzed ring-opening 1,3-aminofunctionalization of donor-acceptor (D-A) cyclopropanes is presented. Using N -halo succinimide (NXS) as the third component, the reaction afforded the 1,3-aminohalogenation product in up to an 84% yield. Moreover, using alkyl halides or Michael acceptors as the third components, the 3,1-carboaminated products are formed in up to a 96% yield in a one-pot operation. Employing Selectfluor as the electrophile, the reaction furnished the 1,3-aminofluorinated product in a 61% yield.

Recently, Molybdenum disulfide (MoS 2 ) has attracted great attention due to its unique characteristics and potential applications in various fields. The advancements in the field have substantially improved at the laboratory scale however, a synthesis approach that produces large area growth of MoS 2 on a wafer scale is the key requirement for the realization of commercial two-dimensional (2D) technology. Herein, we report tunable MoS 2 growth with varied morphologies via radio frequency magnetron sputtering by controlling growth parameters. The controlled growth from in-plane to vertically-aligned (VA) MoS 2 flakes has been achieved on a variety of substrates (Si, Si/SiO 2 , sapphire, quartz, and carbon fiber). Moreover, the growth of VA MoS 2 is highly reproducible and is fabricated on a wafer scale. The flakes synthesized on the wafer show high uniformity, which is corroborated by the spatial mapping using Raman over the entire 2-inch Si/SiO 2 wafer. The detailed morphological, structural, and spectroscopic analysis reveals the transition from in-plane MoS 2 to VA MoS 2 flakes. This work presents a facile approach to directly synthesize layered materials by sputtering technique on wafer scale. This paves the way for designing mass production of high-quality 2D materials, which will advance their practical applications by integration into device architectures in various fields., (© 2023 IOP Publishing Ltd.)

The glomerular filtration rate (GFR) is important for assessing renal function and must be calculated reliably and reproducibly. This study aimed to compare the reliability and accuracy of GFR estimated with 99m-technetium diethylene-triamine-pentaacetate (99mTc-DTPA) versus that calculated from the effective renal plasma flow (ERPF) (GFR is 20% of ERPF) determined by the 99m-technetium ethylene dicysteine (99mTc-EC) technique. Forty-five patients suffering from cancer requiring platinum compound-based chemotherapy or from chronic renal failure were recruited. The patients were divided into two cohorts: (1) those with normal serum creatinine (SCr) levels (≤2 mg/dL) and (2) deranged SCr levels (>2 mg/dL). For all patients, the relative renal function was estimated by the 99mTc-DTPA and 99mTc-EC methods, 2-4 days apart. A 24-h urine sample for estimating 24-h creatinine clearance (CrCl) was obtained. GFR was also calculated using the Modification of Diet in Renal Disease (MDRD) formula. The GFR estimated via 24-h urine CrCl, 99mTc-DTPA, and ERPF obtained with 99mTc-EC were examined by quantile comparison plots, and all showed evidence of following a non-Gaussian distribution. For SCr values ≤2 mg/dL, the GFR estimated by the MDRD formula consistently shows significantly higher values than the GFR estimated with 99mTc-DTPA or 99mTc-EC. We found a high degree of correlation between the 99mTc-DTPA and 99mTc-EC radionuclide methods of estimating GFR. However, in patients with renal dysfunction, GFR estimated through Gates' method using a gamma camera overestimated the GFR; in these patients, calculating the GFR from the ERPF obtained with 99mTc-EC is more accurate., (Copyright © 2023 Copyright: © 2023 Saudi Journal of Kidney Diseases and Transplantation.)

Microvillous inclusion disease (MVID), also known as congenital microvillus atrophy remains an important differential diagnosis of intractable secretory diarrhea in neonatal period. The condition is inherited as an autosomal recessive disorder with no sex predilection and more commonly reported in those tribes with consanguineous marriages. The pathognomonic electron microscopic findings includes villous atrophy with the formation of intracellular microvillous inclusions. Definite treatment includes either isolated small bowel or combined small bowel and liver transplantation. Herein, we are describing a case of intractable diarrhea in a preterm neonate with MVID phenotype presented on second day of life with intractable diarrhea. The diagnosis was established by classical electron microscopic findings in the intestinal biopsy sample.

The recent advances of portable sensors in flexible and wearable form factors are drawing increasing attention worldwide owing to their requirement applications ranging from health monitoring to environment monitoring. While portability is critical for these applications, real-time data gathering also requires a reliable power supply-which is largely met with batteries. Besides the need for regular charging, the use of toxic chemicals in batteries makes it difficult to rely on them, and as a result different types of energy harvesters have been explored in recent years. Among these, triboelectric nanogenerators (TENGs) provide a promising platform for harnessing ambient energy and converting it into usable electric signals. The ease of fabrication and possibility to develop TENGs with a diverse range of easily available materials also make them attractive. This review focuses on the TENG technology and its efficient use as a power source for various types of chemical sensors and biosensors. The paper describes the underlying mechanism, various modes of working of TENGs, and representative examples of their utilization as power sources for sensing a multitude of analytes. The challenges associated with their adoption for commercial solutions are also discussed to stimulate further advances and innovations., Competing Interests: The authors declare no competing financial interest., (© 2022 The Authors. Published by American Chemical Society.)

Objectives: We aimed to evaluate shoulder joint by magnetic resonance imaging (MRI) using the Juvenile Arthritis Magnetic Resonance Imaging Scoring (JAMRIS) system in children with juvenile idiopathic arthritis (JIA) and to compare clinical, laboratory parameters and disease activity scores with MRI parameters., Patients and Methods: A total of 32 shoulder joints of 20 patients (16 males, 4 females; mean age: 8.9±3.5 years; range, 2.5 to 14 years) with a known diagnosis of JIA and a clinical suspicion of shoulder joint involvement and underwent MRI were included. Reliability was determined by inter- and intra-observer correlation coefficients. Correlation of the clinical and laboratory parameters with JAMRIS scores was done using the non-parametric tests. Sensitivity of clinical examination to detect shoulder joint arthritis was also determined., Results: Of the 32 joints, 27 joints in 17 patients showed MRI changes. Seven joints in five patients fulfilled the definition of clinical arthritis, all revealed MRI changes. In 25 joints without clinical arthritis, early and late MRI changes were seen in 19 (67%) and 12 (48%) joints, respectively. The inter- and intra-observer correlation coefficients for JAMRIS system were excellent. No correlation was found between MRI parameters, clinical, laboratory, and disease activity scores. The sensitivity of clinical examination to detect shoulder joint arthritis was 25.9%., Conclusion: The JAMRIS system is reliable and reproducible to determine shoulder joint inflammation in JIA. Detection of shoulder joint arthritis by clinical examination has a poor sensitivity., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article., (Copyright © 2022, Turkish League Against Rheumatism.)

Objective  The aim of this study was to know the tagging efficiencies of technetium-99m labeled sulfur colloid (99mTc-SC) with different meals. Materials and Methods  Egg white sandwiches are the gold standard for gastric-emptying scan (GES); thus, an egg white omelet labeled with 99m Tc-SC is taken as a standard meal. For evaluation, we included four meals, bread and butter, instant oatmeal, idli, and chapatti, and all meals were prepared by labeling them with 99m Tc-SC. After preparation, food articles were chopped with the help of a metal fork and mixed in simulated gastric fluid. Four samples were taken simultaneously from each food article and analyzed for 1 to 4hours after agitation within the centrifuge. The samples were filtered and separated from the sediments and supernatants. We analyzed the activity in each sample before and after filtration. Results  The mean values of labeling efficiency in per cent of various meals were obtained. There was no significant difference in labeling stability for egg whites, chapatti, and idli meals labeled with 99m Tc-SC from 1 to 4hours as their p -value (p>0.05) was insignificant. Conclusion  Radiolabeled chapatti and idli with 99m Tc-SC show higher labeling stability, while oatmeal and bread and butter samples show relatively low stability. Thus, for GES, chapatti and idli labeled with 99m Tc-SC can be used as alternatives to eggs for vegetarian people or for those allergic to eggs., Competing Interests: Conflict of Interest None., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).)

Introduction  Stroke is a major cause of death and disability around the globe. The development of depression following a stroke further increases the disability and impairs functional recovery. In recent decades, despite the advancement in structural and nuclear medicine imaging, the pathophysiologic basis of poststroke depression (PSD) is not well understood. Etiopathogenesis of PSD is multifactorial and afflictions of the frontal lobe, hippocampus, limbic region, and basal ganglia projections are implicated. Aim  The aim of this study was to assess the regional cerebral blood flow (rCBF) using 99m Tc-ethyl cysteinate dimer single-photon emission computed tomography (SPECT) in patients with (PSD + ) or without PSD (PSD-). Materials and Methods  To evaluate the hemispheric asymmetry, the percentage of asymmetry index (AI) was calculated for frontal, temporal, parietal, occipital, putamen, caudate, and thalamic regions of brain and compared between PSD+ and PSD-. The correlation between AIs over the different brain regions was also established in patients of PSD+ and PSD-. Our study cohort included 122 patients between 6 weeks and 1 year of stroke. Depression was present in 52 (42.6%) patients, assessed by hospital anxiety and depression scale (HADS) and general health questionnaire-28 items (GHQ-28) scale. The 28 patients with PSD+ and 18 PSD- gave consent for SPECT study. Results  Our results are based on 46 patients who underwent SPECT study. In patients with PSD+ and PSD-, the HADS and GHQ-28 scores were 8.93 ± 2.77 vs. 3.94 ± 2.15 ( p  = 0.001) and 40.96 ± 9.48 vs. 17.72 ± 5.38 ( p  = 0.001), respectively. A significant difference in rCBF AI was found in the temporal lobe ( p  = 0.03) between patients of PSD+ and PSD-. On logistic regression analysis, the odds ratio of rCBF AI for temporal lobe was 0.89 (95% confidence interval [CI]: 0.80-0.99; p  = 0.04) and caudate nucleus was 0.85 (95% CI: 0.73-0.98; p  = 0.03), which were statistically significant. PSD correlated with AI in temporal region ( r  = -0.03; p  = 0.03) but did not show significant correlation with other regions of brain between PSD+ and PSD-. Conclusion  The presence of temporal lobe rCBF AI on SPECT is significantly associated with PSD. This may reflect the dysfunction of the limbic system and contribute to the occurrence of PSD., Competing Interests: Conflict of Interest None declared., (World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)

A transition-metal-free, [2,3] sigmatropic rearrangement-annulation cascade of 2-substituted thio/amino acetonitriles with arynes allowing the synthesis of 2,4,5-trisubstituted oxazoles under mild conditions has been demonstrated. The key sulfur/nitrogen ylides were generated by the initial S/N arylation followed by proton transfer, which was followed by the selective [2,3] sigmatropic rearrangement involving the -CN moiety and a subsequent annulation to afford the desired products in reasonable yields.

Bismuth containing hybrid molecular ferroelectrics are receiving tremendous attention in recent years owing to their stable and non-toxic composition. However, these perovskite-like structures are primarily limited to ammonium cations. Herein, we report a new phosphonium based discrete perovskite-like hybrid ferroelectric with a formula [Me(Ph) 3 P] 3 [Bi 2 Br 9 ] (MTPBB) and its mechanical energy harvesting capability. The Polarization-Electric field (P-E) measurements resulted in a well-defined ferroelectric hysteresis loop with a remnant polarization value of 2.1 μC cm -2 . Piezoresponse force microscopy experiments enabled visualization of the ferroelectric domain structure and evaluation of the piezoelectric strain coefficient (d 33 ) for an MTPBB single crystal and thin film sample. Furthermore, flexible devices incorporating MTPBB in polydimethylsiloxane (PDMS) matrix at various concentrations were fabricated and explored for their mechanical energy harvesting properties. The champion device with 20 wt % of MTPBB in PDMS rendered a maximum peak-to-peak open-circuit voltage of 22.9 V and a maximum power density of 7 μW cm -2 at an optimal load of 4 MΩ. Moreover, the potential of MTPBB-based devices in low power electronics was demonstrated by storing the harvested energy in various electrolytic capacitors., (© 2022 Wiley-VCH GmbH.)

Touch is a complex sensing modality owing to large number of receptors (mechano, thermal, pain) nonuniformly embedded in the soft skin all over the body. These receptors can gather and encode the large tactile data, allowing us to feel and perceive the real world. This efficient somatosensation far outperforms the touch-sensing capability of most of the state-of-the-art robots today and suggests the need for neural-like hardware for electronic skin (e-skin). This could be attained through either innovative schemes for developing distributed electronics or repurposing the neuromorphic circuits developed for other sensory modalities such as vision and audio. This Review highlights the hardware implementations of various computational building blocks for e-skin and the ways they can be integrated to potentially realize human skin-like or peripheral nervous system-like functionalities. The neural-like sensing and data processing are discussed along with various algorithms and hardware architectures. The integration of ultrathin neuromorphic chips for local computation and the printed electronics on soft substrate used for the development of e-skin over large areas are expected to advance robotic interaction as well as open new avenues for research in medical instrumentation, wearables, electronics, and neuroprosthetics.

An electronic skin (e-skin) for the next generation of robots is expected to have biological skin-like multimodal sensing, signal encoding, and preprocessing. To this end, it is imperative to have high-quality, uniformly responding electronic devices distributed over large areas and capable of delivering synaptic behavior with long- and short-term memory. Here, we present an approach to realize synaptic transistors (12-by-14 array) using ZnO nanowires printed on flexible substrate with 100% yield and high uniformity. The presented devices show synaptic behavior under pulse stimuli, exhibiting excitatory (inhibitory) post-synaptic current, spiking rate-dependent plasticity, and short-term to long-term memory transition. The as-realized transistors demonstrate excellent bio-like synaptic behavior and show great potential for in-hardware learning. This is demonstrated through a prototype computational e-skin, comprising event-driven sensors, synaptic transistors, and spiking neurons that bestow biological skin-like haptic sensations to a robotic hand. With associative learning, the presented computational e-skin could gradually acquire a human body-like pain reflex. The learnt behavior could be strengthened through practice. Such a peripheral nervous system-like localized learning could substantially reduce the data latency and decrease the cognitive load on the robotic platform.

Two-step, ring-opening 1,3-carbothiolation of donor-acceptor (D-A) cyclopropanes employing alkyl halides and in situ generated dithiocarbamates (from amines and CS 2 ) has been demonstrated under mild conditions. The reaction is operationally simple and works with good functional group compatibility. Three new bonds including C-N, C-S, and C-C are formed in this 1,3-bifunctionalization strategy. Electron-poor olefins can also be used as electrophiles instead of alkyl halides. The use of enantiomerically pure D-A cyclopropane afforded enantiopure 1,3-carbothiolated product, thus demonstrating the stereospecificity of the reaction.

Organic ferroelectrics due to their low cost, easy preparation, light weight, high flexibility and phase stability are gaining tremendous attention in the field of portable electronics. In this work, we report the synthesis, structure and ferroelectric behavior of a two-component ammonium salt 2, containing a bulky [Bn(4-BrBn)NMe 2 ] + (Bn=benzyl and 4-BrBn=4-bromobenzyl) cation and tetrahedral (BF 4 ) - anion. The structural analysis revealed the presence of rich non-classical C-H⋅⋅⋅F and C-H⋅⋅⋅Br interactions in this molecule that were quantified by Hirshfeld surface analysis. The polarization (P) vs. electric field (E) hysteresis loop measurements on 2 gave a remnant polarization (P r ) of 14.4 μC cm -2 at room temperature. Flexible polymer composites with various (5, 10, 15 and 20) weight percentages (wt%) of 2 in thermoplastic polyurethane (TPU) were prepared and tested for mechanical energy harvesting applications. A notable peak-to-peak output voltage of 20 V, maximum current density of 1.1 μA cm -2 and power density of 21.1 μW cm -2 were recorded for the 15 wt% 2-TPU composite device. Furthermore, the voltage output generated from this device was utilized to rapidly charge a 100 μF capacitor, with stored energies and measured charges of 156 μJ and 121.6 μC, respectively., (© 2021 Wiley-VCH GmbH.)

A facile synthesis of biologically important S -aryl dithiocarbamates has been demonstrated by the aryne three-component coupling involving CS 2 and aliphatic amines. This transition-metal-free and mild reaction is scalable and operates with good functional group compatibility. Preliminary mechanistic experiments, including density functional theory studies, are also provided. Moreover, with 3-triflyloxybenzynes, a unique four-component coupling incorporating tetrahydrofuran was observed.

Protein expression and turnover are controlled through a complex interplay of transcriptional, post-transcriptional and post-translational mechanisms to enable spatial and temporal regulation of cellular processes. To systematically elucidate such gene regulatory networks, we developed a CRISPR screening assay based on time-controlled Cas9 mutagenesis, intracellular immunostaining and fluorescence-activated cell sorting that enables the identification of regulatory factors independent of their effects on cellular fitness. We pioneered this approach by systematically probing the regulation of the transcription factor MYC, a master regulator of cell growth 1-3 . Our screens uncover a highly conserved protein, AKIRIN2, that is essentially required for nuclear protein degradation. We found that AKIRIN2 forms homodimers that directly bind to fully assembled 20S proteasomes to mediate their nuclear import. During mitosis, proteasomes are excluded from condensing chromatin and re-imported into newly formed daughter nuclei in a highly dynamic, AKIRIN2-dependent process. Cells undergoing mitosis in the absence of AKIRIN2 become devoid of nuclear proteasomes, rapidly causing accumulation of MYC and other nuclear proteins. Collectively, our study reveals a dedicated pathway controlling the nuclear import of proteasomes in vertebrates and establishes a scalable approach to decipher regulators in essential cellular processes., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)

A transition-metal-free, three-component, and diastereoselective [6 + 3] annulation reaction employing tropone, imino esters, and arynes allowing the synthesis of bridged azabicyclo[4.3.1]decadienes is demonstrated. The key nitrogen ylides for the [6 + 3] annulation were generated by the addition of imino esters to the arynes followed by a proton transfer. The nitrogen ylides undergo a regioselective addition to tropone to furnish the desired products in moderate to good yields with good functional group tolerance under mild conditions.

Parboiling rice mills produce a large amount of wastewater. The effluent from the rice mill contains high concentration of organic and inorganic compounds. Continuous discharge of this wastewater from rice mills could be a major cause of eutrophication of the water bodies, leading to a robust and undesirable growth of vegetation and algal bloom. Eutrophication leads to deoxygenation of water bodies, resulting in the mortality of aquatic flora and fauna. It is therefore very important to treat wastewater and ensure safe disposal. There are various types of processes already in existence, but the most important thing is to select a cost-effective technique. Phytoremediation technique has shown promising results for low-income countries like India. It is useful for the small-scale industrial and domestic wastewater treatment. It is a slow process, requiring a large area of land. It is an eco-friendly approach and ideal for rural areas where there is ample land availability. This paper addresses the techniques used by various researchers for rice mill wastewater treatment and also focuses on reusing and recycling of waste from rice mills. The performance of every technique is discussed in detail with its specific advantages and disadvantages. This paper also focuses on the advanced techniques of water treatment with valuable by-products such as silica, activated adsorbent, electricity and methane gas.

The present paper is the result of an investigation carried out to analyse the quality of sub-surface water in the districts of Yamunanagar and Ambala of the province of Haryana in India. The investigation was necessitated as the area combines the presence of industrial, commercial and residential units close to each other. A total of 30 groundwater samples were taken each during the months of April and September of 2017 and were appraised for analytical parameters, hydro-geochemical constituents and metal ions. Eight locations were observed to have an abnormal presence of only one element and were, therefore, classified to be falling in the 'Grey-Zone'. Matedi Bus Stand (Sample number - 23) was found to be adversely influenced by the presence of the most of chemical elements and thus was categorized as the 'Red Zone'. For the combined data of post-monsoon and pre-monsoon periods of 2017, the spatial distribution of pH, TDS, TA and TH showed that 100%, 90%, 91.67% and 93.33% of samples, respectively, fall under allowable limits of groundwater quality. Spatial distribution of hydro-chemical elements and metal ions showed that 96.11% of samples for cations, 98.33% for anions and 93.33% for Fe are in the 'allowable' category of groundwater. A comparison of laboratory results with the GIS maps prepared during the study has been found to be in good agreement. The classification of samples pursuance to their hydro-chemical facies indicated that most of the samples fall in Ca 2+ -Mg 2+ - H C O 3 - -Cl - and Na + - H C O 3 - -Cl - type.

Pathological and experimental studies indicate the existence of a "penumbra" of progressive tissue damage and edema in regions immediately surrounding a hematoma in patients of intracerebral hemorrhage (ICH). This zone of oligemia surrounding ICH has a potential for perfusion recovery. Improved understanding of the pathophysiology of perilesional blood flow changes and brain injury after ICH may result in improved treatment strategies. The aim was to study perilesional blood flow changes in ICH by perfusion deficit (PD) measured by single-photon emission computed tomography (SPECT) and to correlate it with the severity of ICH and outcome. Forty-four patients of computed tomography (CT) documented nonlobar deep ICH suggestive of hypertensive hematoma of <7 days duration were subjected to 99m Tc-ethylene diacetate SPECT scans of the brain. Patients with significant midline shift (0.5 cm) or global blood flow reduction were excluded from the analysis. SPECT scan of the brain was analyzed by segmental analysis, a semi-quantitative method of cerebral blood flow. A difference of radiotracer uptake of >10% between the region of interest of ICH cases and the ratio between the two ROI below 0.9 was taken as a significant PD. A correlation of PD was analyzed with that of various parameters such as the severity of stroke, duration from onset of ictus, and imaging including CT scan of the brain and SPECT scan. A statistically significant difference in the percentage of radiotracer uptake on comparison of ipsilateral and contralateral to ICH ( P < 0.001) was observed, suggesting a significant hypoperfusion in the perilesional area in patients with ICH. A statistically significant correlation was noted between the severity of stroke and PD indicated by various parameters such as the National Institutes of Health Stroke Scale (NIHSS) score at admission (r = 0.328, P = 0.016), Glasgow Coma Scale (GCS) score at admission (r = -0.388, P = 0.005), and ICH score at admission (r = 0.314, P = 0.020). This study demonstrated more severe hypoperfusion in clinically severe ICH which is a possible explanation of poor outcomes in severe ICH cases. We observed hypoperfusion on SPECT study in 25 of 34 (73.5%) patients with subacute ICH and 5 of 10 patients (50%) with acute ICH. The mean time from the onset of ictus to SPECT scan done was 5.04 ± 1.75 days with a range of 1-7 days, suggesting the persistence of hypoperfusion in subacute stages too. This finding may be of clinical importance for identifying the salvageable area surrounding ICH for any possible intervention in future to improve the outcome. This study demonstrates that perilesional PD occurs in acute and subacute cases of ICH. This hypoperfusion is possibly time related and appears to be more severe in patients having major ICH with poor clinical and imaging parameters. This area of hypoperfusion or ischemic penumbra is a potential site for perfusion recovery to improve clinical outcomes and to reduce long-term neurological deficits., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 World Journal of Nuclear Medicine.)

Background/aims: Esophageal transit scintigraphy (ETS) is a useful tool for evaluating esophageal motility disorders, although conflicting results are seen due to lack of ideal bolus. Semisolid/solid boluses have shown superiority over liquid boluses, and the present study aims to establish the utility of in-house-prepared bolus in normal volunteers and its comparison with liquid bolus., Materials and Methods: Thirty-three healthy volunteers were selected for ETS with in-house-prepared semisolid bolus jelly containing 99m Tc-sulfur colloid. Dynamic studies were acquired in anterior projection with single swallow for both supine and sitting positions. T90% esophageal emptying time (EET) was calculated for whole and three equally divided segments of esophagus and also done with liquid bolus on different day., Results: The median value of EET for semisolid bolus for whole esophagus in sitting and supine positions was 11.7 s (interquartile range [IQR]: 8.0-16.7) and 17.7 s (IQR: 12.0-33.0). EET of liquid bolus for whole esophagus in sitting and supine positions was 9.3 s (IQR: 8.0-13.3) and 13.0 s (IQR: 9.7-25.0), respectively. Significantly different EET for whole esophagus and lower one-third esophagus between sitting and supine positions was seen for semisolid (whole esophagus;P = 0.003, lower one-third esophagus; P = 0.025) and liquid boluses (whole esophagus; P = 0.032, lower one-third esophagus; P = 0.016). Comparing EET using semisolid and liquid boluses, only lower one-third esophagus in supine position showed significant difference ( P = 0.033)., Conclusions: In-house-prepared semisolid radiolabeled jelly is inexpensive, easy to prepare with good radiolabeling. Condensed dynamic images from semisolid bolus were better, sharper, and reproducible in comparison to liquid bolus without fragmentation. This study standardized semisolid bolus and verified its suitability for clinical use., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Indian Journal of Nuclear Medicine.)

The aim of the study is to evaluate the minimum number of renal scans required to follow pediatric patients postpyeloplasty. We prospectively reviewed the renal scans of 145 children with unilateral pelvi-ureteric junction obstruction who underwent dismembered pyeloplasty. Patients were then divided into four groups based on preoperative split renal function. All patients were followed with renal scan and ultrasound for minimum of 4 years. Renal scan and ultrasound were done after stent removal at 3, 6, and 12 months and then yearly after surgery. Drainage pattern (T1/2) was seen in all groups, except in patients where there was no comment on drainage pattern. Statistical analysis was performed using the Friedman ANOVA and Wilcoxon signed-ranks test as a post hoc test with Bonferroni correction and Kruskal-Wallis test with Mann-Whitney U-test as a post hoc test with Bonferroni correction. On comparison of the pattern of drainage with time in Groups 1-4, it was found that there was no significant difference with time in Group 1. Then, further, using Wilcoxon signed-rank test as post hoc test for Friedman ANOVA, Group 2 showed statistically significant difference in drainage pattern in scans between 6 months and 1 year, Group 3 showed statistically significant difference in drainage pattern in scans between 3 months and 1 year, and Group 4 showed statistically significant difference in drainage pattern in scans done between 3 and 6 months ( P < 0.05). Minimum of three renal scans were required for paediatric patients post pyeloplasty at 3 months, 6 months and 1 year in the follow up period., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 World Journal of Nuclear Medicine.)

The objective of this study was to investigate the reduction of phosphorus from rice mill wastewater by using free floating aquatic plants. Four free floating aquatic plants were used for this study, namely water hyacinth, water lettuce, salvinia, and duckweed. The aquatic plants reduced the total phosphorus (TP) content up to 80% and chemical oxygen demand (COD) up to 75% within 15 days. The maximum efficiency of TP and COD reduction was observed with water lettuce followed by water hyacinth, duckweed, and salvinia. The study also aims to predict phosphorus removal by three modeling techniques, for example, linear regression (LR), artificial neural network (ANN), and M5P. Prediction has been done considering hydraulic retention time (HRT), hydraulic loading rate (HLR), and initial concentration of phosphorus ( C in ) as input variables whereas the reduction rate of TP ( R ) has been considered as a predicted variable. ANN shows promising results as compared to M5P tree and LR modeling. The model accuracy is analyzed using three statistical evaluation parameters which are coefficient of determination ( R 2 ), root mean square error (RMSE), and means absolute error (MAE).

Objective: To look for change in relative renal function and document renal scarring following endoscopic renal pelvic instillation sclerotherapy (RPIS) in patients with chyluria by dimercaptosuccinic acid (DMSA) renal scan., Methods: A prospective study was performed between November 2015 and September 2016. All patients with biochemically documented chyluria who underwent RPIS using either 1%-silver nitrate or 0.1%-povidine iodine were included. Patients received either 3-, 6- or 9-doses. DMSA renal scan was performed before and 2-3 months after sclerotherapy., Results: Of the 34 patients, 22 were males. Mean age was 41.08 ± 16.64 years (range, 15-70 years). Thirty-two patients (94.1%) responded to therapy while two did not respond even after 9-doses. Average follow-up was 8.94 ± 3.70 months. The mean relative renal function (pre-instillation) of normal kidney was 50.76% ± 3.55% while that of affected renal unit (side of instillation) was 49.20% ± 3.44% (range, 43.0%-61.0%). After instillation therapy, the mean relative renal function of normal side was 52.26% ± 3.57% while that of affected renal unit was 47.50% ± 3.56% (range, 41.0%-54.0%). The relative renal function did not change >5% from the baseline value in any patient except one (in which the differential function increased paradoxically by 12%). Two patients developed renal scar in post-instillation renal scan., Conclusion: Endoscopic sclerotherapy in chyluria is safe and effective. The relative renal function does not deteriorate by more than 5%. There is a small risk of development of renal scar. More studies involving larger number of patients are needed to answer this dilemma., (© 2019 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.)

A triboelectric nanogenerator (TENG) based on natural seeds and electrospun poly(vinyl difluoride) (PVDF) fibers is reported. The nanofibers are specifically used to enhance the triboelectric effects. A mustard (flax) seed based TENG renders an impressively high electrical output with an average open circuit voltage of 84 V (126 V) and maximum power density 334 mW m -2 (324 mW m -2 ) under an impact force of 40 N at 25 Hz. Basil seeds are relatively weaker in power delivery. By comparing the seed crust properties and TENG performances, we analyze the powering capability in terms of the cellulose content in the crust, dielectric constant, and surface morphological features.

Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti-angiogenic treatment has limited efficacy due to therapy-induced blood vessel alterations, often followed by local hypoxia, tumor adaptation, progression, and metastasis. It is therefore paramount to overcome therapy-induced resistance. We show that Apelin inhibition potently remodels the tumor microenvironment, reducing angiogenesis, and effectively blunting tumor growth. Functionally, targeting Apelin improves vessel function and reduces polymorphonuclear myeloid-derived suppressor cell infiltration. Importantly, in mammary and lung cancer, Apelin prevents resistance to anti-angiogenic receptor tyrosine kinase (RTK) inhibitor therapy, reducing growth and angiogenesis in lung and breast cancer models without increased hypoxia in the tumor microenvironment. Apelin blockage also prevents RTK inhibitor-induced metastases, and high Apelin levels correlate with poor prognosis of anti-angiogenic therapy patients. These data identify a druggable anti-angiogenic drug target that reduces tumor blood vessel densities and normalizes the tumor vasculature to decrease metastases., (© 2019 The Authors. Published under the terms of the CC BY 4.0 license.)

This dataset paper aimed to analyse the quality of groundwater of Yamunanagar and Ambala districts in North-Eastern Haryana, India rooted on the various analytical elements and hydro-chemical parameters. Also, Piper and Gibbs diagram were applied to observe hydro-chemical characteristics and controlling constituents of the underground aqua region. The impendence of anions was noted to be tolerable in 93.33% of the spots while 86.67% groundwater samples were observed to be in the desirable limit for cations. The analytical constituents of TH, TA, TDS, and pH were reported to be tolerable in 76.66%, 80%, 60%, and 100% of the water-samples, respectively. Eight water-sampling spots manifested unacceptable ranges of one or more of the physico-chemical constituents. Seven spots were observed to be suffering from one constituent and therefore were classified to be falling in the 'Grey-Zone'. One location (i.e. 23) has been found to be severely influenced by excess of TH, TA, TDS, SO 4 2- , and Ca 2+ and is reported to be falling in the 'Red-Zone'. The classification of groundwater based on Piper diagram depicted that pre-dominant type of sub-surface water hydro-chemical facies of area was 'Ca- Mg- HCO 3 . Gibb's figure revealed that underground water pre-eminence distribution is probably resulted by water-rock dominance in sub-surface water.' . Gibb's figure revealed that underground water pre-eminence distribution is probably resulted by water-rock dominance in sub-surface water.

A detailed understanding of quantization conductance (QC), the correlation with resistive switching phenomena and controlled manipulation of quantized states is crucial for realizing atomic-scale multilevel memory elements. Here, we demonstrate highly stable and reproducible quantized conductance states (QC-states) in Al/niobium oxide/Pt resistive switching devices. Three levels of control over the QC-states, required for multilevel quantized state memories, like, switching ON to different quantized states, switching OFF from quantized states, and controlled inter-state switching among one QC state to another has been demonstrated by imposing limiting conditions of stop-voltage and current compliance. The well-defined multiple QC states along with a working principle for switching among various states show promise for implementation of multilevel memory devices., Competing Interests: The authors declare no competing financial interest., (This journal is © The Royal Society of Chemistry.)