442 results on '"Desoubeaux, Guillaume"'
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52. Advent of elexacaftor/tezacaftor/ivacaftor for cystic fibrosis treatment: What consequences on Aspergillus-related diseases? Preliminary insights
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Chesnay, Adélaïde, primary, Bailly, Éric, additional, Cosson, Laure, additional, Flament, Thomas, additional, and Desoubeaux, Guillaume, additional
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- 2022
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53. P044 Demonstration of the yeasticidal efficacy of povidone-iodine-based commercial antiseptic solutions against Candida auris
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Chesnay, Adélaïde, primary, Bailly, Eric, additional, Evplanov, Victor, additional, Favalli, Filippo, additional, and Desoubeaux, Guillaume, additional
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- 2022
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54. P468 Aspergillosis in a colony of Humboldt penguins (Spheniscus humboldti) under managed care: a clinical and environmental investigation in a French zoological park
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Perraud-Cateau, Estelle, primary, Leclerc, Antoine, additional, Cartier, Noémie, additional, Valsechi, Isabel, additional, Bailly, Eric, additional, Senechal, Ronan Le, additional, Becerra, Margaux, additional, Gallou, Brice Le, additional, Lavergne, Rose-Anne, additional, Chesnay, Adélaïde, additional, Robin, Jean-Patrice, additional, Cray, Carolyn, additional, Goddard, Nicolas, additional, Thorel, Milan, additional, Guillot, Jacques, additional, Mulot, Baptiste, additional, and Desoubeaux, Guillaume, additional
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- 2022
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55. Proteomic demonstration of the recurrent presence of inter-alpha-inhibitor H4 heavy-chain during aspergillosis induced in an animal model
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Desoubeaux, Guillaume, Jourdan, Marie-Lise, Valera, Lionel, Jardin, Bénédicte, Hem, Sonia, Caille, Agnès, Cormier, Bénédicte, Marchand-Adam, Sylvain, Bailly, Éric, Diot, Patrice, and Chandenier, Jacques
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- 2014
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56. Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
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Bretagne, Stéphane, Sitbon, Karine, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Letscher-Bru, Valérie, Cassaing, Sophie, Millon, Laurence, Morio, Florent, Gangneux, Jean-Pierre, Hasseine, Lilia, Favennec, Loïc, Cateau, Estelle, Bailly, Eric, Moniot, Maxime, Bonhomme, Julie, Desbois-Nogard, Nicole, Chouaki, Taieb, Paugam, André, Bouteille, Bernard, Pihet, Marc, Dalle, Frédéric, Eloy, Odile, Sasso, Milène, Demar, Magalie, Mariani-Kurkdjian, Patricia, Robert, Vincent, Lortholary, Olivier, Dromer, Françoise, French Mycoses Study Group, The, Damiani, Céline, Dupont, Hervé, Maizel, Julien, Totet, Anne, Bouchara, Jean-Philippe, Bellanger, Anne Pauline, Berceanu, Ana, Navellou, Jean Christophe, Scherer, Emeline, Abboud, Philippe, Aznar, Christine, Blanchet, Denis, Djossou, Félix, Cayot, Sophie, Garrouste, Cyril, Lesens, Olivier, Moluçon, Cécile, Nourrisson, Céline, Poirier, Philippe, Bailly, Éloïse, Basmaciyan, Louise, Belaid, Bouhemad, Blot, Mathieu, Caillot, Denis, Charles, Pierre-Emmanuel, Quenot, Jean Pierre, Amazan, Emmanuelle, Baubion, Emilie, Cabie, André, Chabartier, Cyrille, Deligny, Christophe, Emal, Violaine, Flechelle, Olivier, Hatchuel, Yves, Le Govic, Yohann, Merle, Harold, Miossec, Charline, Turmel, Jean-Marie, Valentino, Ruddy, Durieux, Marie-Fleur, Turlure, Pascal, Mercier, Victor, Gari-Toussaint, Martine, Risso, Karine, Simon, Loïc, Bretonnière, Cedric, Boutoille, David, Gastinne, Thomas, Lakhal, Karim, Launay, Elise, Lepoivre, Thierry, Peterlin, Pierre, Rialland, Fanny, Le Pape, Patrice, Canoui, Etienne, Dahane, Naima, Kerneis, Solène, Angebault, Cécile, Bougnoux, Marie-Elisabethh, Guennouni, Nadia, Lanternier, Fanny, Neven, Bennedicte, Oualha, Mehdi, Scemla, Anne, Sitterlé, Emilie, Suarez, Felipe, Toubiana, Julie, Bonacorci, Stéphane, Alanio, Alexandre, Bergeron, Anne, Denis, Blandine, Gits-Muselli, Maud, Hamane, Samia, Touratier, Sophie, Chaumeil, Christine, Merabet, Lilia, Claudéon, Joelle, Curlier, Elodie, Galantine, Valérie, Gallois, Jean Claude, Markowicz, Samuel, Nicolas, Muriel, Musson, Pascal, Schepers, Kinda, Minoza, Alida, Kauffmann-Lacroix, Catherine, Guégan, Hélène, Costa, Damien, Dehais, Marion, Gargala, Gilles, Bajolet, Odile, Banisadr, Firouze, Cousson, Joel, Himberlin, Chantal, Huguenin, Antoine, Toubas, Dominique, Flori, Pierre, Mahinc, Caroline, Raberin, Hélène, Denis, Julie, Herbrecht, Raoul, Mertes, Paul-Michel, Meziani, Fehrat, Sabou, Marcela, Schneider, Francis, Bertozzi, Anne-Isabelle, Chauvin, Pamela, Charpentier, Elena, Cointault, Olivier, Cottrel, Claire, Delavigne, Karen, Faguer, Stanislas, Fillaux, Judith, Guemas, Emilie, Iriart, Xavier, Lelièvre, Lucie, Ruiz, Jean, Bastides, Frédéric, Chesnay, Adélaïde, Desoubeaux, Guillaume, Therby, Audrey, Chachaty, Elisabeth, Gachot, Bertrand, Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Software and Databasing, Mycologie moléculaire - Molecular Mycology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals (CNRMA), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Dynamique des interactions hôte pathogène (DIHP), Université de Strasbourg (UNISTRA), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Nantes Université (Nantes Univ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Rouen, Normandie Université (NU), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Clermont-Ferrand, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU de la Martinique [Fort de France], CHU Amiens-Picardie, Hôpital Cochin [AP-HP], CHU Limoges, SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Université d'Angers (UA), Laboratoire de Parasitologie-Mycologie (CHU d'Angers), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Infections Respiratoires Fongiques (IRF), Université d'Angers (UA)-Université de Brest (UBO), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre Hospitalier de Versailles André Mignot (CHV), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Hôpital Robert Debré Paris, Hôpital Robert Debré, Westerdijk Fungal Biodiversity Institute [Utrecht] (WI), Royal Netherlands Academy of Arts and Sciences (KNAW), Service des Maladies infectieuses et tropicales [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Laboratoire de Parasitologie-Mycologie [CHU Angers], Hôpital Bretonneau, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by recurrent financial support from Santé Publique France and Institut Pasteur. The funders had no role in study design, data collection, analysis, interpretation of data, or the decision to submit the work for publication., We thank Didier Che (Direction des Maladies Infectieuses, Santé Publique France) for his continuous support and interest in invasive fungal infections and Etienne Sevin (EpiConcept, Paris, France) for his contribution in the development of the RESSIF website using the VOOZANOO platform. We are thankful for the technical help of Catherine Blanc, Anne Boullié, Cécile Gautier, Virginie Geolier, and Damien Hoinard (Institut Pasteur) for the characterization of the isolates received at the NRCMA., The French Mycoses Study Group includes collaborators who contributed to these data by their involvement in the management of patients, expertise in diagnostic tools, and/or characterization of fungal isolates. They are listed in alphabetical order of a city in France and for each center, in alphabetical order of the last names: in Amiens, Céline Damiani, Hervé Dupont, Julien Maizel, and Anne Totet, in Angers, Jean-Philippe Bouchara, in Besançon, Anne Pauline Bellanger, Ana Berceanu, Jean Christophe Navellou, and Emeline Scherer, in Cayenne, Philippe Abboud, Christine Aznar, Denis Blanchet, and Félix Djossou, in Clermont-Ferrand, Sophie Cayot, Cyril Garrouste, Olivier Lesens, Cécile Moluçon, Céline Nourrisson, and Philippe Poirier, in Dijon, Éloïse Bailly, Louise Basmaciyan, Bouhemad Belaid, Mathieu Blot, Denis Caillot, Pierre-Emmanuel Charles, and Jean Pierre Quenot, in Fort de France, Emmanuelle Amazan, Emilie Baubion, André Cabie, Cyrille Chabartier, Christophe Deligny, Violaine Emal, Olivier Flechelle, Yves Hatchuel, Yohann Le Govic, Harold Merle, Charline Miossec, Jean-Marie Turmel, and Ruddy Valentino, in Limoges, Marie-Fleur Durieux and Pascal Turlure, in Nîmes, Victor Mercier, in Nice, Martine Gari-Toussaint, Karine Risso, and Loïc Simon, in Nantes, Cedric Bretonnière, David Boutoille, Thomas Gastinne, Karim Lakhal, Elise Launay, Thierry Lepoivre, Pierre Peterlin, Fanny Rialland, and Patrice Le Pape, in Paris, in Hôpital Cochin, Etienne Canoui, Naima Dahane, and Solène Kerneis, in Hôpital Necker-Enfants Malades, Cécile Angebault, Marie-Elisabethh Bougnoux, Nadia Guennouni, Fanny Lanternier, Bennedicte Neven, Mehdi Oualha, Anne Scemla, Emilie Sitterlé, Felipe Suarez, and Julie Toubiana, in Hôpital Robert-Debré, Stéphane Bonacorci, in Hôpital Saint-Louis, Alexandre Alanio, Anne Bergeron, Blandine Denis, Maud Gits-Muselli, Samia Hamane, and Sophie Touratier, in hôpital des XV-XX, Christine Chaumeil and Lilia Merabet, in Pointe-à-Pitre, Joelle Claudéon, Elodie Curlier, Valérie Galantine, Jean Claude Gallois, Samuel Markowicz, Muriel Nicolas, Pascal Musson, and Kinda Schepers, in Poitiers, Alida Minoza and Catherine Kauffmann-Lacroix, in Rennes, Hélène Guégan, in Rouen, Damien Costa, Marion Dehais, and Gilles Gargala, in Reims, Odile Bajolet, Firouze Banisadr, Joel Cousson, Chantal Himberlin, Antoine Huguenin, and Dominique Toubas, in Saint Etienne, Pierre Flori, Caroline Mahinc, and Hélène Raberin, in Strabourg, Julie Denis, Raoul Herbrecht, Paul-Michel Mertes, Fehrat Meziani, Marcela Sabou, and Francis Schneider, in Toulouse, Anne-Isabelle Bertozzi, Pamela Chauvin, Elena Charpentier, Olivier Cointault, Claire Cottrel, Karen Delavigne, Stanislas Faguer, Judith Fillaux, Emilie Guemas, Xavier Iriart, Lucie Lelièvre, and Jean Ruiz, in Tours, Frédéric Bastides, Adélaïde Chesnay, and Guillaume Desoubeaux, in Versailles, Audrey Therby, and in Villejuif, Elisabeth Chachaty and Bertrand Gachot., and CLEMENT, Nathalie
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Antifungal Agents ,pneumocytosis ,invasive fungal infections ,Pneumonia, Pneumocystis ,[SDV]Life Sciences [q-bio] ,candidemia ,Microbiology ,[SDV.MP.MYC] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology ,mucormycosis ,[SDV] Life Sciences [q-bio] ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Virology ,Humans ,aspergillosis ,epidemiology ,Watchful Waiting ,Fungemia ,[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology ,[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology ,Aged - Abstract
International audience; The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools.IMPORTANCE The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs. Globally, although the incidence of Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis remained stable over the study period (2012 to 2018), that of yeast fungemia increased slightly. We also show here that IFDs seem to affect older people more frequently. The most worrisome observation is the lack of improvement in the global survival rate associated with IFDs despite the increasing use of more sensitive diagnostic tools, the availability of new antifungal drugs very active in clinical trials, and a still low/marginal rate of acquired in vitro resistance in France. Therefore, other tracks of improvement should be investigated actively.
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- 2022
57. Challenges to establish the diagnosis of aspergillosis in non-laboratory animals: looking for alternatives in veterinary medicine and demonstration of feasibility through two concrete examples in penguins and dolphins
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Desoubeaux, Guillaume, primary, Cray, Carolyn, additional, and Chesnay, Adélaïde, additional
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- 2022
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58. Aspergillosis in a colony of Humboldt penguins (Spheniscus humboldti) under managed care: a clinical and environmental investigation in a French zoological park
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Cateau, Estelle, primary, Leclerc, Antoine, additional, Cartier, Noémie, additional, Valsecchi, Isabel, additional, Bailly, Éric, additional, Le Senechal, Ronan, additional, Becerra, Margaux, additional, Le Gallou, Brice, additional, Lavergne, Rose-Anne, additional, Chesnay, Adélaïde, additional, Robin, Jean-Patrice, additional, Cray, Carolyn, additional, Goddard, Nicolas, additional, Thorel, Milan, additional, Guillot, Jacques, additional, Mulot, Baptiste, additional, and Desoubeaux, Guillaume, additional
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- 2022
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59. Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France
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Tardieu, Laurène, primary, Divard, Gillian, additional, Lortholary, Olivier, additional, Scemla, Anne, additional, Rondeau, Éric, additional, Accoceberry, Isabelle, additional, Agbonon, Rémi, additional, Alanio, Alexandre, additional, Angoulvant, Adela, additional, Albano, Laetitia, additional, Attias, Philippe, additional, Bellanger, Anne Pauline, additional, Bertrand, Dominique, additional, Bonhomme, Julie, additional, Botterel, Françoise, additional, Bouvier, Nicolas, additional, Buchler, Matthias, additional, Chouaki, Taieb, additional, Crépin, Thomas, additional, Durieux, Marie-Fleur, additional, Desoubeaux, Guillaume, additional, Doppelt, Gary, additional, Favennec, Loïc, additional, Fekkar, Arnaud, additional, Fourdinier, Ophélie, additional, Frimat, Marie, additional, Gangneux, Jean-Pierre, additional, Garandeau, Claire, additional, Hasseine, Lilia, additional, Hennequin, Christophe, additional, Iriart, Xavier, additional, Kamar, Nassim, additional, Kaminski, Hannah, additional, Kormann, Raphael, additional, Lachaud, Laurence, additional, Legendre, Christophe, additional, Le Quintrec Donnette, Moglie, additional, Leroy, Jordan, additional, Levi, Charlène, additional, Machouart, Marie, additional, Marx, David, additional, Menotti, Jean, additional, Moal, Valérie, additional, Morio, Florent, additional, Mrozek, Natacha, additional, Nicolas, Muriel, additional, Poirier, Philippe, additional, Peraldi, Marie-Noelle, additional, Poussot, Benjamin, additional, Ranque, Stéphane, additional, Rerolle, Jean-Philippe, additional, Sendid, Boualem, additional, Snanoudj, Renaud, additional, Tourret, Jérôme, additional, Vasse, Marc, additional, Vigneau, Cécile, additional, Villard, Odile, additional, Mesnard, Laurent, additional, Lanternier, Fanny, additional, and Rafat, Cédric, additional
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- 2022
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60. Assessment of the safety and the anti-α-Gal immune response to an oral vaccine in captive-bred Humboldt penguins (Spheniscus humboldti)
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Thorel, Milan, Mateos-Hernandez, Lourdes, Mulot, Baptiste, Azzouni, Mouna Naila, Hodžić, Adnan, Gaillot, Hugues, Ruel, Yannick, Desoubeaux, Guillaume, Delaye, Jean-Baptiste, Obregon, Dasiel, Wu-Chuang, Alejandra, de La Fuente, José, Bermúdez-Humarán, Luis, Risco-Castillo, Veronica, Leclerc, Antoine, Cabezas-Cruz, Alejandro, SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Beauval Nature, Department of Pathobiology, Institute of Parasitology, University of Veterinary Medicine [Vienna] (Vetmeduni)-University of Veterinary Medicine [Vienna] (Vetmeduni), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade de São Paulo (USP), School of environmental sciences, University of Guelph, Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Veterinary Pathobiology, Oklahoma State University [Stillwater], MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dynamic Microbiology - EA 7380 (DYNAMIC), École nationale vétérinaire - Alfort (ENVA)-Université Paris-Est (UPE)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), BioPôle Alfort, École nationale vétérinaire - Alfort (ENVA), ZooParc de Beauval, University of Veterinary Medicine [Vienna] (Vetmeduni), Advetia Specialty Practice, Partenaires INRAE, Oklahoma State University [Stillwater] (OSU), SaBio (CSIC-UCLM-JCCM), and École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est (UPE)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
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MESH: Galactose ,E. coli Nissle 1917 ,MESH: Escherichia coli ,Aspergillus fumigatus ,Spheniscus humboldti ,α-Gal Vaccine ,MESH: Immunoglobulin M ,Escherichia coli Nissle ,MESH: Vaccines ,penguins ,Anti-α-Gal immunity ,probiotics ,MESH: Spheniscidae ,zoo ,vaccine ,Aspergillosis ,MESH: Animals ,MESH: Aspergillosis ,Sphenisciformes ,MESH: Probiotics ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Oral administration of Escherichia coli O86:B7 expressing high levels of galactose-α-1,3galactose (α-Gal) was previously shown to protect turkeys from aspergillosis caused by Aspergillus fumigatus. In the present study, we first tested the basal level of anti-α-Gal antibodies (Abs) in healthy Humboldt penguin (Spheniscus humboldti) sera and penguin egg yolks. We then conducted a trial to test whether modulation of α-Gal immunity by oral administration of the probiotic bacterium Escherichia coli Nissle could prevent Humboldt penguins from aspergillosis. To this aim, E. coli Nissle was administered orally to ten penguins and a placebo was concomitantly given to a control group of ten other penguins. An aspergillosis diagnostic panel (CT scans, capillary zone electrophoresis, 3-hydroxybutyrate levels, anti-A. fumigatus Abs measurements) was implemented before, during and after the interventional procedure in both penguin groups. As results, healthy penguins produced natural anti-α-Gal Abs that were also detected in the egg yolks. Surprisingly, oral administration of E. coli Nissle was associated with lower levels of anti-α-Gal and anti-A. fumigatus Abs compared with the control group. Still, a correlation was seen between anti-E.coli Abs (IgM/IgY) and anti-α-Gal Abs (IgM/IgY), only in the vaccinated penguins. E. coli Nissle is a safe probiotic to use in Humboldt penguins with potential protective effect against aspergillosis to be further tested.
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- 2022
61. Nématodoses intestinales: aspects épidémio-cliniques et diagnostic
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Desoubeaux, Guillaume and Chandenier, Jacques
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- 2012
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62. Assessment of the Safety and Efficacy of an Oral Probiotic-Based Vaccine Against Aspergillus Infection in Captive-Bred Humboldt Penguins (Spheniscus humboldti)
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Thorel, Milan, primary, Mateos-Hernandez, Lourdes, additional, Mulot, Baptiste, additional, Azzouni, Mouna Naila, additional, Hodžić, Adnan, additional, Gaillot, Hugues, additional, Ruel, Yannick, additional, Desoubeaux, Guillaume, additional, Delaye, Jean-Baptiste, additional, Obregon, Dasiel, additional, Wu-Chuang, Alejandra, additional, de la Fuente, José, additional, Bermúdez-Humarán, Luis G., additional, Risco-Castillo, Veronica, additional, Leclerc, Antoine, additional, and Cabezas-Cruz, Alejandro, additional
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- 2022
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63. Intricate isavuconazole therapy of a subcutaneous nodule caused by Alternaria infectoria in a heart transplant recipient
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Maisons, Valentin, primary, Desoubeaux, Guillaume, additional, Coustillères, François, additional, Lemaignen, Adrien, additional, Chesnay, Adelaïde, additional, Doman, Marc, additional, Lanternier, Fanny, additional, Bernard, Louis, additional, and Lacasse, Marion, additional
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- 2022
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64. DETECTION OF GLIOTOXIN BUT NOT BIS(METHYL)GLIOTOXIN IN PLASMA FROM BIRDS WITH CONFIRMED AND PROBABLE ASPERGILLOSIS
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Reidy, Lisa, primary, Desoubeaux, Guillaume, additional, Cardenas, Julia, additional, Seither, Joshua, additional, Kahl, Kristin, additional, Chauvin, David, additional, Adkesson, Michael, additional, Govett, Pamela, additional, Aitken-Palmer, Copper, additional, Stadler, Cynthia, additional, Tocidlowski, Maryanne, additional, Sirpenski, Gayle, additional, Bronson, Ellen, additional, and Cray, Carolyn, additional
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- 2022
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65. Coronavirus Disease 2019-Associated Mucormycosis in France: A Rare but Deadly Complication
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Danion, François, Letscher-Bru, Valérie, Guitard, Juliette, Sitbon, Karine, Dellière, Sarah, Angoulvant, Adela, Desoubeaux, Guillaume, Botterel, Francoise, Bellanger, Anne-Pauline, Gargala, Gilles, Uhel, Fabrice, Bougnoux, Marie-Elisabeth, Gerber, Victor, Michel, Justin, Cornu, Marjorie, Bretagne, Stéphane, Lanternier, Fanny, Merdji, Hamid, Delabranche, Xavier, Parrot, Antoine, Voiriot, Guillaume, Urbina, Tomas, Mebazaa, Alexandre, Chousterman, Benjamin, el Kalioubie, Ahmed, Six, Sophie, Coulon, Pauline, Sendid, Boualem, Anguel, Nadia, Damoisel, Charles, Mussini, Charlotte, Villate, Alban, Navellou, Jean-Christophe, Girault, Christophe, Cassagne, Carole, Augereau, Olivier, Dromer, Francoise, Garcia-Hermoso, Dea, Lortholary, Olivier, Alanio, Alexandre, Center of Experimental and Molecular Medicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (OMICARE), Centre de Recherche d’Immunologie et d’Hématologie [Strasbourg], CHU Strasbourg, Dynamique des interactions hôte pathogène (DIHP), Mucoviscidose: physiopathologie et phénogénomique [CRSA], Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Mycologie moléculaire - Molecular Mycology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals (CNRMA), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), COVID-Mucor study group, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de parasitologie, mycologie, médecine tropicale [CHRU Tours], Dynamic Microbiology - EA 7380 (DYNAMIC), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est (UPE)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Henri Mondor [Créteil], Service de parasitologie et mycologie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire de Biologie Médicale de Référence Pneumopathie d'hypersensibilité, Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Necker - Enfants Malades [AP-HP], Aix Marseille Université (AMU), CHU Lille, Service de Médecine Intensive et Réanimation [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), CHU Tenon [AP-HP], Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), COVID-Mucor St Group Hamid Merdji (Médecine Intensive et Réanimation, Hôpitaux Universitaires de Strasbourg, Strasbourg, France), Xavier Delabranche (Réanimation Chirugicale, Hôpitaux Universitaires de Strasbourg, Strasbourg, France), Antoine Parrot (Service de Pneumologie, Hôpital Tenon, AP-HP, Paris, France), Guillaume Voiriot (Service de Médecine Intensive et Réanimation, Hôpital Tenon, AP-HP, Paris, France), Tomas Urbina (Service de Réanimation Médicale, Hôpital Saint Antoine, AP-HP, Paris, France), Alexandre Mebazaa (Réanimation Chirurgicale, Hôpital Saint-Louis, AP-HP, Paris, France), Benjamin Chousterman (Réanimation, Hôpital Lariboisière, AP-HP, Paris, France), Ahmed El Kalioubie (Réanimation, CHU de Lille), Sophie Six (Réanimation, CHU de Lille, Lille, France), Pauline Coulon and Boualem Sendid (Service de Mycologie, CHU de Lille, France), Nadia Anguel (Réanimation Médicale, Le Kremlin-Bicêtre, AP-HP, Paris, France), Charles Damoisel (Réanimation Polyvalente, Clamart, AP-HP, France), Charlotte Mussini (Service d’Anatomopathologie, Le Kremlin-Bicêtre, AP-HP, Paris, France), Alban Villate (Hématologie, Tours, France), Jean-Christophe Navellou (Réanimation, CHU Besançon, France), Christophe Girault (Médecine Intensive et Réanimation, CHU Rouen, France), Carole Cassagne (Laboratoire de Mycologie, CHU Timone, Marseille, France), Olivier Augereau (Laboratoire de Microbiologie, Colmar, France), Francoise Dromer, Dea Garcia-Hermoso, Olivier Lortholary, Alexandre Alanio (CNRMA, Institut Pasteur, Paris, France)., Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), and Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille)
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medicine.medical_specialty ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,CAM ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Brief Report ,General surgery ,Mucormycosis ,COVID-19 ,CAPA ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,mucormycosis ,AcademicSubjects/MED00290 ,Infectious Diseases ,Oncology ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,medicine ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,business ,Complication - Abstract
We studied COVID-19 associated mucormycosis based on 17 cases reported nationwide and assessed the differences with India. They differed by frequencies of diabetes mellitus (47% in France versus up to 95% in India), hematological malignancies (35% versus 1%), anatomical sites (12% versus >80% rhino-orbito-cerebral) and prognosis (88% mortality versus, We reported 17 cases of COVID-19 associated mucormycosis in France. Compared to India, they differed by frequencies of diabetes mellitus (47% versus up to 95% in India), hematological malignancies (35% versus 1%), anatomical sites and mortality (88% versus
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- 2022
66. Deep-seated dermatophytosis caused by Trichophyton rubrum in patient with Becker muscular dystrophy
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Ouaaziz, Ilham, Marchand, Antoine, Leducq, Sophie, Mirguet, Christian, Pinieux, Gonzague de, Bailly, Éric, Chesnay, Adélaïde, and Desoubeaux, Guillaume
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- 2024
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67. Parasitoses intestinales cosmopolites
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Desoubeaux, Guillaume and Hai Duong, Thanh
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- 2011
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68. Terbinafine Resistance in Dermatophytes: A French Multicenter Prospective Study
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Moreno-Sabater, Alicia, primary, Normand, Anne-Cécile, additional, Bidaud, Anne-Laure, additional, Cremer, Geneviève, additional, Foulet, Françoise, additional, Brun, Sophie, additional, Bonnal, Christine, additional, Aït-Ammar, Nawel, additional, Jabet, Arnaud, additional, Ayachi, Aymen, additional, Piarroux, Renaud, additional, Botterel, Françoise, additional, Houzé, Sandrine, additional, Desoubeaux, Guillaume, additional, Hennequin, Christophe, additional, and Dannaoui, Eric, additional
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- 2022
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69. Pneumocystis Pneumonia: Pitfalls and Hindrances to Establishing a Reliable Animal Model
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Chesnay, Adélaïde, primary, Paget, Christophe, additional, Heuzé-Vourc’h, Nathalie, additional, Baranek, Thomas, additional, and Desoubeaux, Guillaume, additional
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- 2022
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70. Guideline Adherence Predicts Survival of Candidemia in Europe: Results from the ECMM Candida III Multinational European Study
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Hoenigl, Martin, primary, Salmanton-Garcia, Jon, additional, Egger, Matthias, additional, Gangneux, Jean-Pierre, additional, Bicanic, Tihana, additional, Arikan-Akdagli, Sevtap, additional, Alastruey-Izquierdo, Ana, additional, Klimko, Nikolai, additional, Barac, Aleksandra, additional, Özenci, Volkan, additional, Meijer, Eelco F. J., additional, Khanna, Nina, additional, Bassetti, Matteo, additional, Rautemaa-Richardson, Riina, additional, Lagrou, Katrien, additional, Adam, Kai-Manuel, additional, Akalın, Emin Halis, additional, Akova, Murat, additional, Arsic-Arsenijevic, Valentina, additional, Aujayeb, Avinash, additional, Blennow, Ola, additional, Bretagne, Stephane, additional, Danion, François, additional, Denis, Blandine, additional, de Jonge, Nick Alexander, additional, Desoubeaux, Guillaume, additional, Drgona, Lubos, additional, Erben, Nurettin, additional, Gori, Andrea, additional, Rodríguez, Julio García, additional, Garcia-Vidal, Carolina, additional, Giacobbe, Daniele Roberto, additional, Goodman, Anna L., additional, Hamal, Petr, additional, Hammarström, Helena, additional, Toscano, Christina, additional, Lanternier, Fanny, additional, Lass-Flörl, Cornelia, additional, Lockhart, Deborah E. A., additional, Longval, Thomas, additional, Loughlin, Laura, additional, Matos, Tadeja, additional, Mikulska, Malgorzata, additional, Narayanan, Manjusha, additional, Martín-Pérez, Sonia, additional, Prattes, Juergen, additional, Rogers, Benedict, additional, Rahimli, Laman, additional, Ruiz, Maite, additional, Roilides, Emmanuel, additional, Samarkos, Michael, additional, Scharmann, Ulrike, additional, Sili, Uluhan, additional, Sipahi, Oguz Resat, additional, Siváková, Alena, additional, Steinmann, Joerg, additional, Trauth, Janina, additional, Turhan, Özge, additional, Van Praet, Jens, additional, Vena, Antonio, additional, White, Lewis, additional, Willinger, Birgit, additional, Tortorano, Anna Maria, additional, Arendrup, Maiken C., additional, Koehler, Philipp, additional, Cornely, Oliver A., additional, and Group, ECMM Candida III Study, additional
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- 2022
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71. Demonstration of the yeasticidal efficacy of povidone-iodine–based commercial antiseptic solutions against Candida auris
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Chesnay, Adélaïde, Bailly, Éric, and Desoubeaux, Guillaume
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- 2021
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72. Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS‐SPORE registry
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Dumond, Clément, Aulagnon, Florence, Etienne, Isabelle, Heng, Anne‐Elisabeth, Bougnoux, Marie‐Elisabeth, Favennec, Loic, Kamar, Nassim, Iriart, Xavier, Pereira, Bruno, Büchler, Mathias, Desoubeaux, Guillaume, Kaminski, Hannah, Lussac‐Sorton, Florian, Gargala, Gilles, Anglicheau, Dany, Poirier, Philippe, Scemla, Anne, Garrouste, Cyril, Labbe, Franck, Damiani, Céline, Le Govic, Yohann, Totet, Anne, De Gentile, Ludovic, Lemoine, Jean‐Philippe, Bellanger, Anne Pauline, Accoceberry, Isabelle, Delhaes, Laurence, Gabriel, Frédéric, Millet, Pascal, Le Gal, Solène, Nevez, Gilles, Bonhomme, Julie, Capitaine, Agathe, Demar, Magalie, Moniot, Maxime, Nourrisson, Céline, Angebault, Cécile, Botterel, Françoise, Foulet, Françoise, Basmaciyan, Louise, Dalle, Frédéric, Valot, Stéphane, Desbois‐Nogard, Nicole, Robert, Gladys, Deleplancque, Anne‐Sophie, Frealle, Emilie, Leroy, Jordan, Ajzenberg, Daniel, Durieux, Marie‐Fleur, Chapey‐Picq, Emmanuelle, Dupont, Damien, Menotti, Jean, Rabodonirina, Meja, Lollivier, Coralie, Bastien, Patrick, Debourgogne, Anne, Machouart, Marie, Lavergne, Rose‐Anne, Morio, Florent, Delaunay, Pascal, Pomares, Christelle, Simon, Loïc, Sasso, Milène, Argy, Nicolas, Houze, Sandrine, Yera, Hélène, Dannaoui, Eric, Sitterle, Emilie, Kapel, Nathalie, Tantaoui, Ilhame, Thellier, Marc, Belkadi, Ghania Belkacem, Moreno‐Sabater, Alicia, Hamane, Samia, Nicolas, Muriel, Perraud, Estelle, Chemla, Cathy, Villena, Isabelle, Autier, Brice, Costa, Damien, Flori, Pierre, Brunet, Julie, BERRY, Antoine, Chesnay, Adélaïde, Artur, Fabienne, Verdurme, Laura, Foulquier, Jean‐Baptiste, Prigent, Gwenole, Chatelain, Rémi, Lesthelle, Sophie, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Laboratoire de Parasitologie et Mycologiede [CHRU Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Clermont-Ferrand, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Rouen, Normandie Université (NU), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Bordeaux [Bordeaux], Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] (3IHP ), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Reims (CHU Reims), Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle (ESCAPE), Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)
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Male ,medicine.medical_specialty ,Opportunistic infection ,[SDV]Life Sciences [q-bio] ,030230 surgery ,Microsporidiosis ,Gastroenterology ,Albendazole ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,parasitic diseases ,medicine ,Humans ,Enterocytozoon bieneusi ,Fumagillin ,Registries ,Kidney transplantation ,ComputingMilieux_MISCELLANEOUS ,Aged ,0303 health sciences ,Transplantation ,biology ,030306 microbiology ,business.industry ,Enterocytozoon ,Middle Aged ,Spores, Fungal ,fumagillin ,medicine.disease ,biology.organism_classification ,Kidney Transplantation ,3. Good health ,immunosuppressive regimen ,Diarrhea ,Infectious Diseases ,medicine.symptom ,business ,medicine.drug - Abstract
Introduction Microsporidiosis is an emerging opportunistic infection in renal transplantation (RT) recipients. We aimed to describe its clinical presentation and treatment. Materials and methods We collected microsporidiosis cases identified in RT recipients between 2005 and 2019 in six French centers from the Crystal, Divat and Astre prospective databases. Results We report 68 RT recipients with intestinal microsporidiosis; the patients were predominantly male (61.8%), with a median age of 58 (46-69) years. Infection occurred at a median time of 3 (0.8-6.8) years posttransplant. Only Enterocytozoon bieneusi was found. Microsporidiosis manifested as diarrhea (98.5% of patients) with weight loss (72.1%) and acute renal injury (57.4%) without inflammatory biological parameters. The therapeutic approaches were no treatment (N = 9), reduction of the immunosuppressive regimen (∆IS) (N = 22), fumagillin alone (N = 9), fumagillin and ∆IS (N = 19), and albendazole or nitazoxanide and ∆IS (N = 9). Overall clinical remission was observed in 60 patients (88.2%). We observed no acute kidney rejection, renal transplant failure or death within 6 months after microsporidiosis. Conclusion E. bieneusi is an underestimated opportunistic pathogen in RT recipients, and infection with E. bieneusi leads to diarrhea with important dehydration and acute renal injury. The treatment is based on the reduction of the immunosuppressive regimen and the administration of fumagillin if available. This article is protected by copyright. All rights reserved.
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- 2021
73. Congenital trypanosomiasis in child born in France to African mother
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De Kyvon, Marie-Alix Lestrade-Carluer, Maakaroun-Vermesse, Zoha, Lanotte, Philippe, Priotto, Gerardo, Perez-Simarro, Pere, Guennoc, Anne-Marie, De Toffol, Bertrand, Paris, Luc, Bernard, Louis, Goudeau, Alain, Chandenier, Jacques, and Desoubeaux, Guillaume
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Genetic disorders -- Case studies -- Diagnosis -- Care and treatment ,Trypanosomiasis -- Case studies -- Diagnosis -- Care and treatment ,Health - Abstract
To the Editor: Sleeping sickness, or human African trypanosomiasis, is a neglected tropical parasitic infection transmitted by the tsetse fly bite. In central and western Africa, trypanosomiasis is caused by [...]
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- 2016
74. Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn)
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Salmanton-García, Jon, Seidel, Danila, Koehler, Philipp, Mellinghoff, Sibylle, Herbrecht, Raoul, Klimko, Nikolai, Ráčil, Zdeněk, Falces-Romero, Iker, Ingram, Paul, Benítez-Peñuela, Miguel-Ángel, Rodríguez, José Yesid, Desoubeaux, Guillaume, Barać, Aleksandra, García-Vidal, Carolina, Hoenigl, Martin, Mehta, Sanjay, Cheng, Matthew, Klyasova, Galina, Heinz, Werner, Iqbal, Nousheen, Krause, Robert, Ostermann, Helmut, Penack, Olaf, Schalk, Enrico, Sheppard, Donald, Willinger, Birgit, Wisplinghoff, Hilmar, Vehreschild, J Janne, Cornely, Oliver, Vehreschild, Maria, Khedr, Reham Abdelaziz, Arencibia-Núñez, Alberto, Avilés-Robles, Martha, Banke, Ingo, Basher, Ariful, Benachinamardi, Keertilaxmi, Bertz, Harmut, Chakrabarti, Arunaloke, Drgona, Lubos, García-Martínez, Jesús, García-Rodríguez, Julio, Gräber, Sandra, Härter, Georg, Klein, Michael, Kouba, Michal, Lee, Dong-Gun, Le Govic, Yohann, Leo, Fabian, Maertens, Johan, Maschmeyer, Georg, Meintker, Lisa, Mo, Xiao-Dong, Müller, Lena-Katharina, Müller, Nicolas, Nel, Jeremy Stephen, Novák, Jan, Patel, Atul, Pfäfflin, Frieder, Pozo-Laderas, Juan-Carlos, Puerta-Alcalde, Pedro, Rodríguez-Guardado, Azucena, Schroers, Roland, Shekar, Vandana, Shenoi, Susan, Silling, Gerda, Vinh, Donald, Waizel-Haiat, Salomón, Yee Yee, Mandy Yap, Prakash, Peralam Yegneswaran, Žák, Pavel, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Service d'Hématologie, CHU Strasbourg, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine, Medical University Graz, Schwerpunkt Infektiologie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Department of Haematology and Oncology, Medical Clinic III, University Hospital Munich—Großhadern, Ludwig Maximilian University, Klinik für Hämatologie und Onkologie, Charité, Campus Benjamin Franklin, Department of Haematology/Oncology, Magdeburg University Hospital, McGill University = Université McGill [Montréal, Canada], Medizinische Universität Wien = Medical University of Vienna, University Hospital of Cologne [Cologne], Postgraduate Institute of Medical Education and Research, Laboratoire de psychologie cognitive (LPC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Anofel Cryptosporidium National Network, Department of Hematology, University Hospital Gasthuisberg, Medizinische Klinik, Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Real Expression Artificial Life (IRIT-REVA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Medizinische Klinik A des Universitätsklinikums Münster, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University Hospital Gasthuisberg [Leuven], Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Male ,0301 basic medicine ,Posaconazole ,Antifungal Agents ,[SDV]Life Sciences [q-bio] ,Gastroenterology ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Amphotericin B ,Pharmacology (medical) ,Prospective Studies ,Registries ,030212 general & internal medicine ,Child ,Prospective cohort study ,[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology ,ComputingMilieux_MISCELLANEOUS ,Antiinfective agent ,Standard treatment ,Middle Aged ,3. Good health ,Infectious Diseases ,Tolerability ,Child, Preschool ,Mucorales ,Female ,medicine.drug ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,Adolescent ,Drug Compounding ,Matched-Pair Analysis ,030106 microbiology ,Young Adult ,03 medical and health sciences ,Pharmacokinetics ,Internal medicine ,parasitic diseases ,medicine ,Humans ,Mucormycosis ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,[INFO]Computer Science [cs] ,Aged ,Pharmacology ,business.industry ,Infant, Newborn ,Infant ,Triazoles ,medicine.disease ,business ,MESH: amphotericin b, antifungal agents, cancer, kidney failure, mucormycosis, surgical procedures, operative, suspensions, mortality, posaconazole ,Invasive Fungal Infections - Abstract
Background First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage treatment options are limited and often based on posaconazole oral suspension. With the approval of posaconazole new formulations, patients could benefit from improved pharmacokinetics, safety and tolerability. Objectives Our aim was to assess the effectiveness of posaconazole new formulations for IM treatment. Methods We performed a case-matched analysis with proven or probable IM patients from the FungiScope® Registry. First-line posaconazole new formulations (1st-POSnew) and first-line amphotericin B plus posaconazole new formulations (1st-AMB+POSnew) cases were matched with first-line amphotericin B-based (1st-AMB) treatment controls. Salvage posaconazole new formulations (SAL-POSnew) cases were matched with salvage posaconazole oral suspension (SAL-POSsusp) controls. Each case was matched with up to three controls (based on severity, haematological/oncological malignancy, surgery and/or renal dysfunction). Results Five patients receiving 1st-POSnew, 18 receiving 1st-AMB+POSnew and 22 receiving SAL-POSnew were identified. By day 42, a favourable response was reported for 80.0% (n = 4/5) of patients receiving 1st-POSnew, for 27.8% (n = 5/18) receiving 1st-AMB+POSnew and for 50.0% (n = 11/22) receiving SAL-POSnew. Day 42 all-cause mortality of patients receiving posaconazole new formulations was lower compared with controls [20.0% (n = 1/5) in 1st-POSnew versus 53.3% (n = 8/15) in 1st-AMB; 33.3% (n = 6/18) in 1st-AMB+POSnew versus 52.0% (n = 26/50) in 1st-AMB; and 0.0% (n = 0/22) in SAL-POSnew versus 4.4% (n = 2/45) in SAL-POSsusp]. Conclusions Posaconazole new formulations were effective in terms of treatment response and associated mortality of IM. While posaconazole new formulations may be an alternative for treatment of IM, the limited sample size of our study calls for a cautious interpretation of these observations.
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- 2019
75. In vitro Studies and Clinical Trials about Monoclonal Antibodies Used in Infectiology
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Desoubeaux, Guillaume, primary
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- 2014
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76. Morocco as a possible source for acquisition of Rhinocladiella mackenziei
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Lafont Rapnouil, Baptiste, primary, Cohen, Jérémie F., additional, Bailly, Eric, additional, Bernard, Louis, additional, Garcia-Hermoso, Dea, additional, Lanternier, Fanny, additional, Horodyckid, Catherine, additional, Limousin, Lucie, additional, Salamé, Ephrem, additional, Zemmoura, Ilyess, additional, Desoubeaux, Guillaume, additional, and Lortholary, Olivier, additional
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- 2021
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77. Case Report: Progressive Dysphonia and Dysphagia due to Laryngeal Leishmaniasis
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Renard, Laura, primary, Lemaignen, Adrien, additional, Desoubeaux, Guillaume, additional, and Bakhos, David, additional
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- 2021
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78. Invasive infections with Purpureocillium lilacinum: clinical characteristics and outcome of 101 cases from FungiScope (R) and the literature
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Sprute, Rosanne, Salmanton-Garcia, Jon, Sal, Ertan, Malaj, Xhorxha, Racil, Zdenek, de Alegria Puig, Carlos Ruiz, Falces-Romero, Iker, Barac, Aleksandra, Desoubeaux, Guillaume, Kindo, Anupma Jyoti, Morris, Arthur J., Pelletier, Rene, Steinmann, Joerg, Thompson, George R., Cornely, Oliver A., Seidel, Danila, Stemler, Jannik, Sprute, Rosanne, Salmanton-Garcia, Jon, Sal, Ertan, Malaj, Xhorxha, Racil, Zdenek, de Alegria Puig, Carlos Ruiz, Falces-Romero, Iker, Barac, Aleksandra, Desoubeaux, Guillaume, Kindo, Anupma Jyoti, Morris, Arthur J., Pelletier, Rene, Steinmann, Joerg, Thompson, George R., Cornely, Oliver A., Seidel, Danila, and Stemler, Jannik
- Abstract
Objectives: To provide a basis for clinical management decisions in Purpureocillium lilacinum infection. Methods: Unpublished cases of invasive P. lilacinum infection from the FungiScope (R) registry and all cases reported in the literature were analysed. Results: We identified 101 cases with invasive P. lilacinum infection. Main predisposing factors were haematological and oncological diseases in 31 cases (30.7%), steroid treatment in 27 cases (26.7%), solid organ transplant in 26 cases (25.7%), and diabetes mellitus in 19 cases (18.8%). The most prevalent infection sites were skin (n = 37/101, 36.6%) and lungs (n = 26/101, 25.7%). Dissemination occurred in 22 cases (21.8%). Pain and fever were the most frequent symptoms (n = 40/101, 39.6% and n = 34/101, 33.7%, respectively). Diagnosis was established by culture in 98 cases (97.0%). P. lilacinum caused breakthrough infection in 10 patients (9.9%). Clinical isolates were frequently resistant to amphotericin B, whereas posaconazole and voriconazole showed good in vitro activity. Susceptibility to echinocandins varied considerably. Systemic antifungal treatment was administered in 90 patients (89.1%). Frequently employed antifungals were voriconazole in 51 (56.7%) and itraconazole in 26 patients (28.9%). Amphotericin B treatment was significantly associated with high mortality rates (n = 13/33, 39.4%, P = <0.001). Overall mortality was 21.8% (n = 22/101) and death was attributed to P. lilacinum infection in 45.5%(n = 10/22). Conclusions: P. lilacinum mainly presents as soft-tissue, pulmonary or disseminated infection in immuno-compromised patients. Owing to intrinsic resistance, accurate species identification and susceptibility testing are vital. Outcome is better in patients treated with triazoles compared with amphotericin B formulations.
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- 2021
79. Re: ‘Which trial do we need? Combination treatment of Pneumocystis jirovecii pneumonia in non-HIV infected patients’ by Cornely et al.
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Desoubeaux, Guillaume, Lemaignen, Adrien, Alanio, Alexandre, and Ehrmann, Stephan
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- 2023
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80. Scientific rationale for inhaled caspofungin to treat Pneumocystis pneumonia: A therapeutic innovation likely relevant to investigate in a near future…
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Desoubeaux, Guillaume, Lemaignen, Adrien, and Ehrmann, Stephan
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- 2020
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81. Ekbom’s syndrome or real ectoparasitosis? An unexpected outcome of hidden springtails
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Desoubeaux, Guillaume, Saada, Armand, Bailly, Eric, Guiguen, Claude, and Chandenier, Jacques
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- 2014
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82. Some undesirable traps which can mislead the pathologist
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Mercier, Victor, primary, Sasso, Milène, additional, Kouyoumdjian, Pascal, additional, Sizaret, Damien, additional, Benzimra, Simon, additional, Gonzalez, Samia, additional, and Desoubeaux, Guillaume, additional
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- 2021
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83. Pruritic zosteriform papules of the trunk: a rare manifestation of late cutaneous schistosomiasis
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Steinmayer, Laura, primary, Nicoletis, Irène, additional, Leducq, Sophie, additional, Verdier, Dominique, additional, Faivre, Benjamin, additional, Desoubeaux, Guillaume, additional, and Samimi, Mahtab, additional
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- 2021
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84. Antiparasitic treatments in pregnant women: Update and recommendations
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Boitel, E, Desoubeaux, Guillaume, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Tératogénicité ,Paludisme ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Malaria ,Teratogenicity ,Fetal death ,Hypotrophie ,Mutagenicity ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Low birth weight ,Morts foetales in utero ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Mutagénicité - Abstract
International audience; Parasitoses are a major cause of morbidity and mortality worldwide, especially in resource-poor countries where the prevalence of such infections is very high. Their consequences for pregnant women are a public health issue. It is very challenging to successfully control parasitic infections with the dedicated drugs, while protecting the fetus from the harmful effects of these medications. However, in both temperate and tropical regions, true antiparasitic innovations are rare, and the therapeutic armamentarium remains limited. Scientific data is incomplete as only a few clinical studies have included pregnant women so far. Therefore, physicians have to learn how to thoroughly handle the antiparasitic molecules available. They also need to know the embryo-and fetotoxic effects of each of them. Medical practices must be adapted to the trimester of pregnancy.; Les parasitoses constituent une importante cause de morbi-mortalité dans le monde, et plus particulièrement dans les pays à faibles ressources où la prévalence de telles infections est très élevée. Leurs conséquences chez la femme enceinte constituent un problème de santé publique. Savoir maîtriser les infections, souvent associées entre elles, sans risquer de nuire à la grossesse et à l'intégrité du foetus, représente donc un réel défi pour le thérapeute. Pourtant, en régions tempérées comme tropicales, les vraies révolutions antiparasitaires sont rares et l'arsenal thérapeutique demeure limité. Les informations scientifiques sont lacunaires car les études cliniques incluant des femmes enceintes sont peu nombreuses. Le prescripteur doit donc savoir jongler astucieusement avec les molécules actives à disposition, et connaître les effets embryo-et foetotoxiques de chacune d'elles. Les pratiques médicales doivent être adaptées au terme de la grossesse et à l'urgence à traiter la mère.
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- 2020
85. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections
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Salmanton-Garcia, Jon, Koehler, Philipp, Kindo, Anupma, Falces-Romero, Iker, Garcia-Rodriguez, Julio, Racil, Zdenek, Chen, Sharon C-A, Klimko, Nikolai, Desoubeaux, Guillaume, Thompson, George R., III, Benitez-Penuela, Miguel-Angel, Rodriguez, Jose-Yesid, Sheppard, Donald C., Hoenigl, Martin, Le Govic, Yohann, Badali, Hamid, Baddley, John W., Chander, Jagdish, Ingram, Paul R., Pakstis, Diana L., Mellinghoff, Sibylle C., Atici, Serkan, Cesaro, Simone, Chakrabarti, Arunaloke, Dupont, Damien, Gonzalez, Gloria M., Hatvani, Lorant, Herbrecht, Raoul, Klyasova, Galina, Lass-Florl, Cornelia, Mares, Mihai, Mullane, Kathleen, Vinh, Donald C., Wisplinghoff, Hilmar, Lackner, Michaela, Cornely, Oliver A., Seidel, Danila, Salmanton-Garcia, Jon, Koehler, Philipp, Kindo, Anupma, Falces-Romero, Iker, Garcia-Rodriguez, Julio, Racil, Zdenek, Chen, Sharon C-A, Klimko, Nikolai, Desoubeaux, Guillaume, Thompson, George R., III, Benitez-Penuela, Miguel-Angel, Rodriguez, Jose-Yesid, Sheppard, Donald C., Hoenigl, Martin, Le Govic, Yohann, Badali, Hamid, Baddley, John W., Chander, Jagdish, Ingram, Paul R., Pakstis, Diana L., Mellinghoff, Sibylle C., Atici, Serkan, Cesaro, Simone, Chakrabarti, Arunaloke, Dupont, Damien, Gonzalez, Gloria M., Hatvani, Lorant, Herbrecht, Raoul, Klyasova, Galina, Lass-Florl, Cornelia, Mares, Mihai, Mullane, Kathleen, Vinh, Donald C., Wisplinghoff, Hilmar, Lackner, Michaela, Cornely, Oliver A., and Seidel, Danila
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Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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- 2020
86. Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives
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Mayor, Alexie, primary, Chesnay, Adélaïde, additional, Desoubeaux, Guillaume, additional, Ternant, David, additional, Heuzé-Vourc’h, Nathalie, additional, and Sécher, Thomas, additional
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- 2021
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87. Ancylostoma ceylanicum as the second most frequent hookworm species isolated in France in travellers returning from tropical areas
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Gerber, Victor, primary, Le Govic, Yohann, additional, Ramade, Cécile, additional, Chemla, Cathy, additional, Hamane, Samia, additional, Desoubeaux, Guillaume, additional, Durieux, Marie-Fleur, additional, Degeilh, Brigitte, additional, Abou-Bacar, Ahmed, additional, Pfaff, Alexander W, additional, Candolfi, Ermanno, additional, Greigert, Valentin, additional, and Brunet, Julie, additional
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- 2021
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88. High Prevalence of Fungal Infections in Mechanically Ventilated COVID-19 Patients in the ICU: The French Multicenter MYCOVID Study
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Gangneux, Jean Pierre, primary, Dannaoui, Eric, additional, Fekkar, Arnaud, additional, Luyt, Charles Edouard, additional, Botterel, Francoise, additional, de Prost, Nicolas, additional, Tadie, Jean Marc, additional, Reizine, Florian, additional, Houze, Sandrine, additional, Timsit, Jean-François, additional, Iriart, Xavier, additional, Riu-Poulenc, Béatrice, additional, Sendid, Boualem, additional, Nseir, Saad, additional, Persat, Florence, additional, Wallet, Florent, additional, Le Pape, Patrice, additional, Canet, Emmanuel, additional, Novara, Ana, additional, Manai, Melek, additional, Cateau, Estelle, additional, Thille, Arnaud W., additional, Brun, Sophie, additional, Cohen, Yves, additional, Alanio, Alexandre, additional, Megarbane, Bruno, additional, Cornet, Muriel, additional, Terzi, Nicolas, additional, Lamhaut, Lionel, additional, Sabourin, Estelle, additional, Desoubeaux, Guillaume, additional, Ehrmann, Stephan, additional, Hennequin, Christophe, additional, Voiriot, Guillaume, additional, Nevez, Gilles, additional, Aubron, Cécile, additional, Letscher-Bru, Valérie, additional, Meziani, Ferhat, additional, Blaize, Marion, additional, Mayaux, Julien, additional, Monsel, Antoine, additional, Boquel, Frederique, additional, Robert-Gangneux, Florence, additional, Le Tulzo, Yves, additional, Seguin, Philippe, additional, Guegan, Hélène, additional, Autier, Brice, additional, Lesouhaitier, Mathieu, additional, Pelletier, Romain, additional, Belaz, Sorya, additional, Bonnal, Christine, additional, Berry, Antoine, additional, Leroy, Jordan, additional, François, Nadine, additional, Richard, Jean-Christophe, additional, Paulus, Sylvie, additional, Argaud, Laurent, additional, Dupont, Damien, additional, Menotti, Jean, additional, Morio, Florent, additional, Soulié, Marie, additional, Schwebel, Carole, additional, Garnaud, Cécile, additional, Guitard, Juliette, additional, Le Gal, Solène, additional, Quinio, Dorothée, additional, Morcet, Jeff, additional, Laviolle, Bruno, additional, Zahar, Jean-Ralph, additional, and Bougnoux, Marie-Elisabeth, additional
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- 2021
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89. Contribution of a molecular test for the diagnosis of genital infection with Trichomonas vaginalis and Mycoplasma genitalium
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Chesnay, Adélaïde, additional, Lancelin, Benoit, additional, Le Brun, Cécile, additional, Pastuszka, Adeline, additional, Desoubeaux, Guillaume, additional, and Lanotte, Philippe, additional
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- 2020
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90. A Nebulized Intra-tracheal Rat Model of Invasive Pulmonary Aspergillosis
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Desoubeaux, Guillaume, primary and Chandenier, Jacques, additional
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- 2012
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91. Therapeutic antibodies and infectious diseases: Tours, France, November 20-22, 2012
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Desoubeaux, Guillaume, Daguet, Arnaud, and Watier, Hervé
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- 2013
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92. Two cases of opportunistic parasite infections in patients receiving alemtuzumab
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Desoubeaux, Guillaume, Caumont, Charline, Passot, Christophe, Dartigeas, Caroline, Bailly, Éric, Chandenier, Jacques, and Duong, Thanh Haï
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- 2012
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93. Bioorganic Farming Practices as a Source of Atypical Ectoparasitosis
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Desoubeaux, Guillaume, Amara, Marlène, Goustille, Julien, and Chandenier, Jacques
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- 2011
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94. Molecular identification of Pentatrichomonas hominis in two patients with gastrointestinal symptoms
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Meloni, Dionigia, Mantini, Cléa, Goustille, Julien, Desoubeaux, Guillaume, Maakaroun-Vermesse, Zoha, Chandenier, Jacques, Gantois, Nausicaa, Duboucher, Christophe, Fiori, Pier Luigi, Dei-Cas, Eduardo, Duong, Thanh Hai, and Viscogliosi, Eric
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- 2011
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95. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ—Global Registry for Emerging Fungal Infections
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Salmanton-García, Jon, primary, Koehler, Philipp, additional, Kindo, Anupma, additional, Falces-Romero, Iker, additional, García-Rodríguez, Julio, additional, Ráčil, Zdeněk, additional, Chen, Sharon C.-A., additional, Klimko, Nikolai, additional, Desoubeaux, Guillaume, additional, Thompson, George R., additional, Benítez-Peñuela, Miguel-Ángel, additional, Rodríguez, José-Yesid, additional, Sheppard, Donald C., additional, Hoenigl, Martin, additional, Le Govic, Yohann, additional, Badali, Hamid, additional, Baddley, John W., additional, Chander, Jagdish, additional, Ingram, Paul R., additional, Pakstis, Diana L., additional, Mellinghoff, Sibylle C., additional, Atıcı, Serkan, additional, Cesaro, Simone, additional, Chakrabarti, Arunaloke, additional, Dupont, Damien, additional, González, Gloria M., additional, Hatvani, Lóránt, additional, Herbrecht, Raoul, additional, Klyasova, Galina, additional, Lass-Flörl, Cornelia, additional, Mareș, Mihai, additional, Mullane, Kathleen, additional, Vinh, Donald C., additional, Wisplinghoff, Hilmar, additional, Lackner, Michaela, additional, Cornely, Oliver A., additional, Seidel, Danila, additional, Alexander, Barbara D., additional, Almagro-Molto, María, additional, Álvarez-Duarte, Eduardo, additional, Avilés-Robles, Martha, additional, Barać, Aleksandra, additional, Chrenková, Vanda, additional, Cornejo-Juárez, Patricia, additional, Desbois-Nogard, Nicole, additional, Fernández-Ruiz, Mario, additional, Figueira, Luis, additional, García-Martínez, Jesús, additional, Gräber, Sandra, additional, Graf, Barbara, additional, Haerter, Georg, additional, Haider, Shariq, additional, Hartman, Pamela, additional, Heinemann, Melina, additional, Ikram, Aamer, additional, Janvier, Frédéric, additional, Jenks, Jeffrey D., additional, Kauffman, Carol, additional, Krause, Robert, additional, Luong, Me-Linh, additional, Malik, Shruti, additional, Marconi, Vincent, additional, Martino, Rodrigo, additional, Mehta, Sanjay R., additional, Meintker, Lisa, additional, Mocná, Andrea, additional, Morris, Michele I., additional, Pasqualotto, Alessandro C., additional, Patel, Atul, additional, Penack, Olaf, additional, Pichon, Nicolas, additional, Pletz, Mathias W., additional, Seas, Carlos, additional, Sili, Uluhan, additional, Slavin, Monica, additional, Uno, Kenji, additional, Vazquez, Jose A., additional, Weber, Thomas, additional, Weinbergerova, Barbora, additional, Yilmaz-Karapinar, Deniz, additional, Yilmaz-Semerci, Seda, additional, and Yu, Jin, additional
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- 2020
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96. Controlled Heat and Humidity-Based Treatment for the Reuse of Personal Protective Equipment: A Pragmatic Proof-of-Concept to Address the Mass Shortage of Surgical Masks and N95/FFP2 Respirators and to Prevent the SARS-CoV2 Transmission
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Bernard, Louis, primary, Desoubeaux, Guillaume, additional, Bodier-Montagutelli, Elsa, additional, Pardessus, Jeoffrey, additional, Brea, Déborah, additional, Allimonnier, Laurine, additional, Eymieux, Sébastien, additional, Raynal, Pierre-Ivan, additional, Vasseur, Virginie, additional, Vecellio, Laurent, additional, Mathé, Ludovic, additional, Guillon, Antoine, additional, Lanotte, Philippe, additional, Pourchez, Jérémie, additional, Verhoeven, Paul O., additional, Esnouf, Stéphane, additional, Ferry, Muriel, additional, Eterradossi, Nicolas, additional, Blanchard, Yannick, additional, Brown, Paul, additional, Roingeard, Philippe, additional, Alcaraz, Jean-Pierre, additional, Cinquin, Philippe, additional, Si-Tahar, Mustapha, additional, and Heuzé-Vourc'h, Nathalie, additional
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- 2020
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97. 1598. Clinical implications of azole-resistant vs. azole-susceptible invasive aspergillosis in hematological malignancy (CLARITY) – a multicenter study
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Seidel, Danila, primary, Cornely, Oliver, additional, Zarrouk, Marouan, additional, Koehler, Philipp, additional, Meis, Jacques F, additional, Salmanton-García, Jon, additional, Vehreschild, Jörg Janne, additional, Christner, Martin, additional, Gräfe, Stefanie K, additional, Falces-Romero, Iker, additional, Lagrou, Katrien, additional, Maertens, Johan, additional, Reséndiz- Sharpe, Agustín, additional, Racil, Zdenek, additional, Weinbergerová, Barbora, additional, Valerio, Maricela, additional, Muñoz, Patricia, additional, Blennow, Ola, additional, Rammaert, Blandine, additional, Ostojic, Alen, additional, Govic, Yohann Le, additional, Lass-Flörl, Cornelia, additional, Rössler, Susann, additional, van Dijk, Karin, additional, de Jong, Nick, additional, Steinmann, Jörg, additional, Desoubeaux, Guillaume, additional, Alakel, Nael, additional, Klimko, Nikolay, additional, Schalk, Enrico, additional, Brenier-Pinchart, Marie-Pierre, additional, Garcia-Vidal, Carolina, additional, Bergeron, Anne, additional, Cho, Sung-Yeon, additional, Melchers, Willem J G, additional, Vehreschild, Maria J G T, additional, and Verweij, Paul E, additional
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- 2020
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98. Reply to the reply to Scientific rationale for inhaled caspofungin to treat Pneumocystis pneumonia: A therapeutic innovation likely relevant to investigate in a near future …
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Desoubeaux, Guillaume, primary, Lemaignen, Adrien, additional, and Ehrmann, Stephan, additional
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- 2020
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99. Challenging diagnosis of chronic cerebral fungal infection: Value of (1→3)-ß-D-glucan and mannan antigen testing in cerebrospinal fluid and of cerebral ventricle puncture
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Hobson, Claire A, primary, Desoubeaux, Guillaume, additional, Carvalho-Schneider, Claudia, additional, Destrieux, Christophe, additional, Cottier, Jean-Philippe, additional, Garot, Denis, additional, Le Brun, Cécile, additional, Maakaroun, Zoha, additional, Lemaignen, Adrien, additional, Bailly, Éric, additional, and Bernard, Louis, additional
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- 2020
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100. Tricks and misuses of rapid diagnostic testing for malaria diagnosis
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Mercier, Victor, additional, Bailly, Éric, additional, Van Langendonck, Nathalie, additional, Chevallier, Eloi, additional, Bernard, Louis, additional, and Desoubeaux, Guillaume, additional
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- 2020
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