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51. The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk

Author

Kong, So Yeon Takeuchi, Masayoshi Hyogo, Hideyuki and McKeown-Eyssen, Gail Yamagishi, Sho-Ichi Chayama, Kazuaki and O'Brien, Peter J. Ferrari, Pietro Overvad, Kim Olsen, Anja and Tjonneland, Anne Boutron-Ruault, Marie-Christine Bastide, Nadia Carbonnel, Franck Kuehn, Tilman Kaaks, Rudolf and Boeing, Heiner Aleksandrova, Krasimira Trichopoulou, Antonia and Lagiou, Pagona Vasilopoulou, Effie Masala, Giovanna Pala, Valeria De Magistris, Maria Santucci Tumino, Rosario and Naccarati, Alessio Bueno-De-Mesquita, H. B. Peeters, Petra H. and Weiderpass, Elisabete Quiros, J. Ramon Jakszyn, Paula and Sanchez, Maria-Jose Dorronsoro, Miren Gavrila, Diana and Ardanaz, Eva Rutegard, Martin Nystroem, Hanna Wareham, Nicholas J. Khaw, Kay-Tee Bradbury, Kathryn E. Romieu, Isabelle Freisling, Heinz Stavropoulou, Faidra Gunter, Marc J. Cross, Amanda J. Riboli, Elio Jenab, Mazda Bruce, W. Robert

Abstract

Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer. Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1: 1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status. Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.571.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity = 0.14). Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development. (C) 2015 AACR.

Published
2015

52. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Leenders, Max Siersema, Peter D. Overvad, Kim Tjonneland, Anne Olsen, Anja Boutron-Ruault, Marie-Christine Bastide, Nadia Fagherazzi, Guy Katzke, Verena Kuehn, Tilman and Boeing, Heiner Aleksandrova, Krasimira Trichopoulou, Antonia and Lagiou, Pagona Klinaki, Eleni Masala, Giovanna Grioni, Sara and De Magistris, Maria Santucci Tumino, Rosario Ricceri, Fulvio and Peeters, Petra H. M. Lund, Eiliv Skeie, Guri Weiderpass, Elisabete Ramon Quiros, J. Agudo, Antonio Sanchez, Maria-Jose Dorronsoro, Miren Navarro, Carmen Ardanaz, Eva and Ohlsson, Bodil Jirstroem, Karin Van Guelpen, Bethany and Wennberg, Maria Khaw, Kay-Tee Wareham, Nick Key, Timothy J. and Romieu, Isabelle Huybrechts, Inge Cross, Amanda J. and Murphy, Neil Riboli, Elio Bueno-de-Mesquita, H. B(As)

Abstract

Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of 9 years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and a variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of 13 years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95% CI 0.75-1.01, p for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than 10 years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but appears unlikely.

Published
2015

53. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Author

Moskal, Aurelie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjonneland, Anne, Petersen, Kristina E. N., Dahm, Christina C., Plambeck Hansen, Camilla, Affret, Aurelie, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Kuhn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-De-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Huerta Castano, Jose M., Quiros, Jose R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay-Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., Slimani, Nadia, Moskal, Aurelie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjonneland, Anne, Petersen, Kristina E. N., Dahm, Christina C., Plambeck Hansen, Camilla, Affret, Aurelie, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Kuhn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-De-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Huerta Castano, Jose M., Quiros, Jose R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay-Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., and Slimani, Nadia

Abstract

Background: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors. Results: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d. = 0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.) = 0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk. Conclusions: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

Published
2016
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54. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Foerster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmeron, Diego, Ramon Quiros, Jose, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Mesquita, H. Bas Bueno, Bakker, Marije F., Peeters, Petra H. M., Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, Ferrari, Pietro, Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Foerster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmeron, Diego, Ramon Quiros, Jose, Olsen, Anja, Tjonneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Mesquita, H. Bas Bueno, Bakker, Marije F., Peeters, Petra H. M., Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, and Ferrari, Pietro

Abstract

Objective Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology. Design Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confidence intervals computed using Cox proportional hazards models quantified the association between quintiles of nutrient pattern scores and risk of overall BC, and by hormonal receptor and menopausal status. Principal component analysis was applied for comparison. Setting The European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects Women (n 334 850) from the EPIC study. Results The first TT component (TC1) highlighted a pattern rich in nutrients found in animal foods loading on cholesterol, protein, retinol, vitamins B-12 and D, while the second TT component (TC2) reflected a diet rich in -carotene, riboflavin, thiamin, vitamins C and B-6, fibre, Fe, Ca, K, Mg, P and folate. While TC1 was not associated with BC risk, TC2 was inversely associated with BC risk overall (HRQ5 v. Q1=089, 95 % CI 083, 095, P-trend<001) and showed a significantly lower risk in oestrogen receptor-positive (HRQ5 v. Q1=089, 95 % CI 081, 098, P-trend=002) and progesterone receptor-positive tumours (HRQ5 v. Q1=087, 95 % CI 077, 098, P-trend<001). Conclusions TT produces readily interpretable sparse components explaining similar amounts of variation as principal component analysis. Our results suggest that participants with a nutrient pattern high in micronutrients found in vegetables, fruits and cereals had a lower risk of BC.

Published
2016
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55. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A., Hemon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjonneland, Anne, Kyro, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Engeset, Dagrun, Skeie, Guri, Hjartaker, Anette, Menendez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, Scalbert, Augustin, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A., Hemon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjonneland, Anne, Kyro, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Engeset, Dagrun, Skeie, Guri, Hjartaker, Anette, Menendez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin

Published
2016

56. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Moskal, Aurélie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjønneland, Anne, Petersen, Kristina EN, Dahm, Christina C., Hansen, Camilla Plambeck, Affret, Aurélie, Boutron-Ruault, Marie Christine, Cadeau, Claire, Kühn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-de-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Castaño, José M Huerta, Quirós, José R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., Slimani, Nadia, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Moskal, Aurélie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjønneland, Anne, Petersen, Kristina EN, Dahm, Christina C., Hansen, Camilla Plambeck, Affret, Aurélie, Boutron-Ruault, Marie Christine, Cadeau, Claire, Kühn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-de-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Castaño, José M Huerta, Quirós, José R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., and Slimani, Nadia

Published
2016

57. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, Slimani, Nadia, Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, and Slimani, Nadia

Published
2016

58. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Förster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmerón, Diego, Quirós, José Ramón, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnès, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. Bas, Bakker, Marije F., Peeters, Petra H M, Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, Ferrari, Pietro, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Epi Kanker Team A, Assi, Nada, Moskal, Aurelie, Slimani, Nadia, Viallon, Vivian, Chajes, Veronique, Freisling, Heinz, Monni, Stefano, Knueppel, Sven, Förster, Jana, Weiderpass, Elisabete, Lujan-Barroso, Leila, Amiano, Pilar, Ardanaz, Eva, Molina-Montes, Esther, Salmerón, Diego, Quirós, José Ramón, Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Overvad, Kim, Dossus, Laure, Fournier, Agnès, Baglietto, Laura, Fortner, Renee Turzanski, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, De Magistris, Maria Santucci, Masala, Giovanna, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. Bas, Bakker, Marije F., Peeters, Petra H M, Skeie, Guri, Braaten, Tonje, Winkvist, Anna, Johansson, Ingegerd, Khaw, Kay Tee, Wareham, Nicholas J., Key, Tim, Travis, Ruth, Schmidt, Julie A., Merritt, Melissa A., Riboli, Elio, Romieu, Isabelle, and Ferrari, Pietro

Published
2016

59. Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study

Author

Moskal, Aurelie Pisa, Pedro T. Ferrari, Pietro Byrnes, Graham Freisling, Heinz Boutron-Ruault, Marie-Christine and Cadeau, Claire Nailler, Laura Wendt, Andrea Kuehn, Tilman and Boeing, Heiner Buijsse, Brian Tjonneland, Anne Halkjaer, Jytte Dahm, Christina C. Chiuve, Stephanie E. Quiros, Jose R. Buckland, Genevieve Molina-Montes, Esther Amiano, Pilar and Huerta Castano, Jose M. Barricarte Gurrea, Aurelio Khaw, Kay-Tee Lentjes, Marleen A. Key, Timothy J. Romaguera, Dora and Vergnaud, Anne-Claire Trichopoulou, Antonia Bamia, Christina and Orfanos, Philippos Palli, Domenico Pala, Valeria Tumino, Rosario Sacerdote, Carlotta de Magistris, Maria Santucci and Bueno-de-Mesquita, H. Bas Ocke, Marga C. Beulens, Joline W. J. and Ericson, Ulrika Drake, Isabel Nilsson, Lena M. Winkvist, Anna Weiderpass, Elisabete Hjartaker, Anette Riboli, Elio and Slimani, Nadia

Abstract

Background: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. Methodology/Principal Findings: We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. Conclusion/Significance: The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research opportunities and perspectives of using nutrient patterns in future studies particularly at international level.

Published
2014

60. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Author

Moskal, Aurélie, primary, Freisling, Heinz, additional, Byrnes, Graham, additional, Assi, Nada, additional, Fahey, Michael T, additional, Jenab, Mazda, additional, Ferrari, Pietro, additional, Tjønneland, Anne, additional, Petersen, Kristina EN, additional, Dahm, Christina C, additional, Hansen, Camilla Plambeck, additional, Affret, Aurélie, additional, Boutron-Ruault, Marie-Christine, additional, Cadeau, Claire, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Iqbal, Khalid, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Naska, Androniki, additional, Masala, Giovanna, additional, de Magistris, Maria Santucci, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Peeters, Petra H, additional, Bueno-de-Mesquita, Bas H, additional, Engeset, Dagrun, additional, Licaj, Idlir, additional, Skeie, Guri, additional, Ardanaz, Eva, additional, Buckland, Genevieve, additional, Castaño, José M Huerta, additional, Quirós, José R, additional, Amiano, Pilar, additional, Molina-Portillo, Elena, additional, Winkvist, Anna, additional, Myte, Robin, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Perez-Cornago, Aurora, additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Huybrechts, Inge, additional, Tsilidis, Konstantinos K, additional, Ward, Heather, additional, Gunter, Marc J, additional, and Slimani, Nadia, additional

Published
2016
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61. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Author

Obón-Santacana, Mireia, primary, Lujan-Barroso, Leila, additional, Freisling, Heinz, additional, Cadeau, Claire, additional, Fagherazzi, Guy, additional, Boutron-Ruault, Marie-Christine, additional, Kaaks, Rudolf, additional, Fortner, Renée T., additional, Boeing, Heiner, additional, Ramón Quirós, J., additional, Molina-Montes, Esther, additional, Chamosa, Saioa, additional, Castaño, José María Huerta, additional, Ardanaz, Eva, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Key, Tim, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Naska, Androniki, additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, De Magistris, Maria Santucci, additional, Bueno-de-Mesquita, H. B., additional, Peeters, Petra H., additional, Wennberg, Maria, additional, Bergdahl, Ingvar A., additional, Vesper, Hubert, additional, Riboli, Elio, additional, and Duell, Eric J., additional

Published
2016
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62. The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk

Author

Kong, So Yeon, Takeuchi, Masayoshi, Hyogo, Hideyuki, McKeown-Eyssen, Gail, Yamagishi, Sho-Ichi, Chayama, Kazuaki, O'Brien, Peter J., Ferrari, Pietro, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Bastide, Nadia, Carbonnel, Franck, Kuehn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, De Magistris, Maria Santucci, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, H. B., Peeters, Petra H., Weiderpass, Elisabete, Quiros, J. Ramon, Jakszyn, Paula, Sanchez, Maria-Jose, Dorronsoro, Miren, Gavrila, Diana, Ardanaz, Eva, Rutegård, Martin, Nyström, Hanna, Wareham, Nicholas J., Khaw, Kay-Tee, Bradbury, Kathryn E., Romieu, Isabelle, Freisling, Heinz, Stavropoulou, Faidra, Gunter, Marc J., Cross, Amanda J., Riboli, Elio, Jenab, Mazda, Bruce, W. Robert, Kong, So Yeon, Takeuchi, Masayoshi, Hyogo, Hideyuki, McKeown-Eyssen, Gail, Yamagishi, Sho-Ichi, Chayama, Kazuaki, O'Brien, Peter J., Ferrari, Pietro, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Bastide, Nadia, Carbonnel, Franck, Kuehn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, De Magistris, Maria Santucci, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, H. B., Peeters, Petra H., Weiderpass, Elisabete, Quiros, J. Ramon, Jakszyn, Paula, Sanchez, Maria-Jose, Dorronsoro, Miren, Gavrila, Diana, Ardanaz, Eva, Rutegård, Martin, Nyström, Hanna, Wareham, Nicholas J., Khaw, Kay-Tee, Bradbury, Kathryn E., Romieu, Isabelle, Freisling, Heinz, Stavropoulou, Faidra, Gunter, Marc J., Cross, Amanda J., Riboli, Elio, Jenab, Mazda, and Bruce, W. Robert

Abstract

Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer. Methods: A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1: 1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status. Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.571.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity = 0.14). Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development.

Published
2015
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63. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Leenders, Max, Siersema, Peter D, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Bastide, Nadia, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Grioni, Sara, De Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Peeters, Petra H M, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirós, J Ramón, Agudo, Antonio, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Ohlsson, Bodil, Jirström, Karin, Van Guelpen, Bethany, Wennberg, Maria, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Romieu, Isabelle, Huybrechts, Inge, Cross, Amanda J, Murphy, Neil, Riboli, Elio, Bueno-de-Mesquita, H Bas, Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Leenders, Max, Siersema, Peter D, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Bastide, Nadia, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Grioni, Sara, De Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Peeters, Petra H M, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirós, J Ramón, Agudo, Antonio, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Ohlsson, Bodil, Jirström, Karin, Van Guelpen, Bethany, Wennberg, Maria, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Romieu, Isabelle, Huybrechts, Inge, Cross, Amanda J, Murphy, Neil, Riboli, Elio, and Bueno-de-Mesquita, H Bas

Published
2015

64. The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk

Author

Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Kong, So Yeon, Takeuchi, Masayoshi, Hyogo, Hideyuki, McKeown-Eyssen, Gail, Yamagishi, Sho Ichi, Chayama, Kazuaki, O'Brien, Peter J., Ferrari, Pietro, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Bastide, Nadia, Carbonnel, Franck, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, De Magistris, Maria Santucci, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, H. B., Peeters, Petra H., Weiderpass, Elisabete, Quiŕos, J. Ramón, Jakszyn, Paula, ͆anchez, María Jos̈e, Dorronsoro, Miren, Gavrila, Diana, Ardanaz, Eva, Rutegård, Martin, Nyström, Hanna, Wareham, Nicholas J., Khaw, Kay Tee, Bradbury, Kathryn E., Romieu, Isabelle, Freisling, Heinz, Stavropoulou, Faidra, Gunter, Marc J., Cross, Amanda J., Riboli, Elio, Jenab, Mazda, Bruce, W. Robert, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Kong, So Yeon, Takeuchi, Masayoshi, Hyogo, Hideyuki, McKeown-Eyssen, Gail, Yamagishi, Sho Ichi, Chayama, Kazuaki, O'Brien, Peter J., Ferrari, Pietro, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Bastide, Nadia, Carbonnel, Franck, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, De Magistris, Maria Santucci, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, H. B., Peeters, Petra H., Weiderpass, Elisabete, Quiŕos, J. Ramón, Jakszyn, Paula, ͆anchez, María Jos̈e, Dorronsoro, Miren, Gavrila, Diana, Ardanaz, Eva, Rutegård, Martin, Nyström, Hanna, Wareham, Nicholas J., Khaw, Kay Tee, Bradbury, Kathryn E., Romieu, Isabelle, Freisling, Heinz, Stavropoulou, Faidra, Gunter, Marc J., Cross, Amanda J., Riboli, Elio, Jenab, Mazda, and Bruce, W. Robert

Published
2015

65. Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul Knaze, Viktoria Lujan-Barroso, Leila and Romieu, Isabelle Scalbert, Augustin Slimani, Nadia and Hjartaker, Anette Engeset, Dagrun Skeie, Guri Overvad, Kim and Bredsdorff, Lea Tjonneland, Anne Halkjaer, Jytte Key, Timothy J. Khaw, Kay-Tee Mulligan, Angela A. Winkvist, Anna and Johansson, Ingegerd Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Wallstrom, Peter Ericson, Ulrika Pala, Valeria de Magistris, Maria Santucci Polidoro, Silvia Tumino, Rosario and Trichopoulou, Antonia Dilis, Vardis Katsoulis, Michael Maria Huerta, Jose Martinez, Virginia Sanchez, Maria-Jose Ardanaz, Eva Amiano, Pilar Teucher, Birgit Grote, Verena and Bendinelli, Benedetta Boeing, Heiner Foerster, Jana and Touillaud, Marina Perquier, Florence Fagherazzi, Guy Gallo, Valentina Riboli, Elio Gonzalez, Carlos A.

Subjects
food and beverages
Abstract

A greater adherence to the traditional Mediterranean (MED) diet is associated with a reduced risk of developing chronic diseases. This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED and non-MED countries participating in the EPIC study. Flavonoid intakes and their food sources for 35 628 subjects, aged 35-74 years and recruited between 1992 and 2000, in twenty-six study centres were estimated using standardised 24 h dietary recall software (EPIC-Soft (R)). An ad hoc food composition database on flavonoids was compiled using analytical data from the United States Department of Agriculture and Phenol-Explorer databases. Moreover, it was expanded to include using recipes, estimations of missing values and flavonoid retention factors. No significant differences in total flavonoid mean intake between non-MED countries (373.7 mg/d) and MED countries (370.2 mg/d) were observed. In the non-MED region, the main contributors were proanthocyanidins (48.2 %) and flavan-3-ol monomers (24.9 %) and the principal food sources were tea (25.7 %) and fruits (32.8 %). In the MED region, proanthocyanidins (59.0 %) were by far the most abundant contributor and fruits (55.1 %), wines (16.7 %) and tea (6.8 %) were the main food sources. The present study shows similar results for total dietary flavonoid intakes, but significant differences in flavonoid class intakes, food sources and some characteristics between MED and non-MED countries. These differences should be considered in studies about the relationships between flavonoid intake and chronic diseases.

Published
2013

66. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort

Author

Zamora-Ros, Raul Knaze, Viktoria Lujan-Barroso, Leila and Slimani, Nadia Romieu, Isabelle Fedirko, Veronika de Magistris, Maria Santucci Ericson, Ulrica Amiano, Pilar and Trichopoulou, Antonia Dilis, Vardis Naska, Androniki and Engeset, Dagrun Skeie, Guri Cassidy, Aedin Overvad, Kim and Peeters, Petra H. M. Maria Huerta, Jose Sanchez, Maria-Jose and Ramon Quiros, J. Sacerdote, Carlotta Grioni, Sara Tumino, Rosario Johansson, Gerd Johansson, Ingegerd Drake, Isabel and Crowe, Francesca L. Barricarte, Aurelio Kaaks, Rudolf and Teucher, Birgit Bueno-de-Mesquita, H. Bas van Rossum, Caroline T. M. Norat, Teresa Romaguera, Dora Vergnaud, Anne-Claire and Tjonneland, Anne Halkjaer, Jytte Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine Touillaud, Marina Salvini, Simonetta Khaw, Kay-Thee Wareham, Nicholas Boeing, Heiner and Foerster, Jana Riboli, Elio Gonzalez, Carlos A.

Abstract

Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo. We aimed to estimate the FLAV dietary intake, their food sources and associated lifestyle factors in ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. FLAV intake and their food sources for 36 037 subjects, aged between 35 and 74 years, in twenty-seven study centres were obtained using standardised 24 h dietary recall software (EPIC-SOFT). An ad hoc food composition database on FLAV was compiled using data from US Department of Agriculture and Phenol-Explorer databases and was expanded using recipes, estimations and flavonoid retention factors in order to increase its correspondence with the 24 h dietary recall. Our results showed that the highest FLAV-consuming centre was the UK health-conscious group, with 130.9 and 97.0 mg/d for men and women, respectively. The lowest FLAV intakes were 36.8 mg/d in men from Umea and 37.2 mg/d in women from Malmo (Sweden). The flavanone sub-class was the main contributor to the total FLAV intake ranging from 46.6 to 52.9% depending on the region. Flavonols ranged from 38.5 to 47.3% and flavones from 5.8 to 8.6%. FLAV intake was higher in women, non-smokers, increased with level of education and physical activity. The major food sources were citrus fruits and citrus-based juices (especially for flavanones), tea, wine, other fruits and some vegetables. We concluded that the present study shows heterogeneity in intake of these three sub-classes of flavonoids across European regions and highlights differences by sex and other sociodemographic and lifestyle factors.

Published
2011

67. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Author

Freisling, Heinz, primary, Pisa, Pedro T., additional, Ferrari, Pietro, additional, Byrnes, Graham, additional, Moskal, Aurelie, additional, Dahm, Christina C., additional, Vergnaud, Anne-Claire, additional, Boutron-Ruault, Marie-Christine, additional, Fagherazzi, Guy, additional, Cadeau, Claire, additional, Kühn, Tilman, additional, Neamat-Allah, Jasmine, additional, Buijsse, Brian, additional, Boeing, Heiner, additional, Halkjær, Jytte, additional, Tjonneland, Anne, additional, Hansen, Camilla P., additional, Quirós, J. Ramón, additional, Travier, Noémie, additional, Molina-Montes, Esther, additional, Amiano, Pilar, additional, Huerta, José M., additional, Barricarte, Aurelio, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas, additional, Key, Tim J., additional, Romaguera, Dora, additional, Lu, Yunxia, additional, Lassale, Camille M., additional, Naska, Androniki, additional, Orfanos, Philippos, additional, Trichopoulou, Antonia, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Berrino, Franco, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, de Magistris, Maria Santucci, additional, Bueno-de-Mesquita, H. Bas, additional, Ocké, Marga C., additional, Sonestedt, Emily, additional, Ericson, Ulrika, additional, Johansson, Mattias, additional, Skeie, Guri, additional, Weiderpass, Elisabete, additional, Braaten, Tonje, additional, Peeters, Petra H. M., additional, and Slimani, Nadia, additional

Published
2015
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68. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, primary, Knaze, Viktoria, additional, Rothwell, Joseph A., additional, Hémon, Bertrand, additional, Moskal, Aurelie, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Fagherazzi, Guy, additional, Boutron-Ruault, Marie-Christine, additional, Touillaud, Marina, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Förster, Jana, additional, Trichopoulou, Antonia, additional, Valanou, Elissavet, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, de Magistris, Maria Santucci, additional, Peeters, Petra H. M., additional, Bueno-de-Mesquita, H. Bas, additional, Engeset, Dagrun, additional, Skeie, Guri, additional, Hjartåker, Anette, additional, Menéndez, Virginia, additional, Agudo, Antonio, additional, Molina-Montes, Esther, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Sonestedt, Emily, additional, Nilsson, Lena Maria, additional, Landberg, Rikard, additional, Key, Timothy J., additional, Khaw, Kay-Thee, additional, Wareham, Nicholas J., additional, Lu, Yunxia, additional, Slimani, Nadia, additional, Romieu, Isabelle, additional, Riboli, Elio, additional, and Scalbert, Augustin, additional

Published
2015
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69. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Assi, Nada, primary, Moskal, Aurelie, additional, Slimani, Nadia, additional, Viallon, Vivian, additional, Chajes, Veronique, additional, Freisling, Heinz, additional, Monni, Stefano, additional, Knueppel, Sven, additional, Förster, Jana, additional, Weiderpass, Elisabete, additional, Lujan-Barroso, Leila, additional, Amiano, Pilar, additional, Ardanaz, Eva, additional, Molina-Montes, Esther, additional, Salmerón, Diego, additional, Quirós, José Ramón, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Dossus, Laure, additional, Fournier, Agnès, additional, Baglietto, Laura, additional, Fortner, Renee Turzanski, additional, Kaaks, Rudolf, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Orfanos, Philippos, additional, De Magistris, Maria Santucci, additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, Bueno de Mesquita, H Bas, additional, Bakker, Marije F, additional, Peeters, Petra HM, additional, Skeie, Guri, additional, Braaten, Tonje, additional, Winkvist, Anna, additional, Johansson, Ingegerd, additional, Khaw, Kay-Tee, additional, Wareham, Nicholas J, additional, Key, Tim, additional, Travis, Ruth, additional, Schmidt, Julie A, additional, Merritt, Melissa A, additional, Riboli, Elio, additional, Romieu, Isabelle, additional, and Ferrari, Pietro, additional

Published
2015
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70. Nutrient Patterns and Their Food Sources in an International Study Setting : Report from the EPIC Study

Author

Moskal, Aurelie, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Freisling, Heinz, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Nailler, Laura, Wendt, Andrea, Kuehn, Tilman, Boeing, Heiner, Buijsse, Brian, Tjonneland, Anne, Halkjaer, Jytte, Dahm, Christina C., Chiuve, Stephanie E., Quiros, Jose R., Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Huerta Castano, Jose M., Barricarte Gurrea, Aurelio, Khaw, Kay-Tee, Lentjes, Marleen A., Key, Timothy J., Romaguera, Dora, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Sacerdote, Carlotta, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocke, Marga C., Beulens, Joline W. J., Ericson, Ulrika, Drake, Isabel, Nilsson, Lena M., Winkvist, Anna, Weiderpass, Elisabete, Hjartaker, Anette, Riboli, Elio, Slimani, Nadia, Moskal, Aurelie, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Freisling, Heinz, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Nailler, Laura, Wendt, Andrea, Kuehn, Tilman, Boeing, Heiner, Buijsse, Brian, Tjonneland, Anne, Halkjaer, Jytte, Dahm, Christina C., Chiuve, Stephanie E., Quiros, Jose R., Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Huerta Castano, Jose M., Barricarte Gurrea, Aurelio, Khaw, Kay-Tee, Lentjes, Marleen A., Key, Timothy J., Romaguera, Dora, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Sacerdote, Carlotta, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocke, Marga C., Beulens, Joline W. J., Ericson, Ulrika, Drake, Isabel, Nilsson, Lena M., Winkvist, Anna, Weiderpass, Elisabete, Hjartaker, Anette, Riboli, Elio, and Slimani, Nadia

Abstract

Background: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. Methodology/Principal Findings: We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. Conclusion/Significance: The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term

Published
2014
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71. Eating out of home and its correlates in 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Orfanos, Philippos Naska, Androniki Trichopoulos, Dimitrios and Slimani, Nadia Ferrari, Pietro van Bakel, Marit Deharveng, Genevieve Overvad, Kim Tionneland, Anne Halkjaer, Jytte and de Magistris, Maria Santucci Tumino, Rosario Pala, Valeria and Sacerdote, Carlotta Masala, Giovanna Skeie, Guri Engeset, Dagrun Lund, Eiliv Jakszyn, Paula Barricarte, Aurelio and Chirlaque, Maria-Dolores Martinez-Garcia, Carmen Amiano, Pilar and Quiros, J. Ramon Bingham, Sheila Welch, Ailsa Spencer, Elizabeth A. Key, Timothy J. Rohrmann, Sabine Linseisen, Jakob Ray, Jennifer Boeing, Heiner Peeters, Petra H. and Bueno-De-Mesquita, H. Bas Ocke, Marga Johansson, Ingegerd and Johansson, Gerd Berglund, Goran Manjer, Jonas and Boutron-Ruault, Marie-Christine Touvier, Mathilde and Clavel-Chapelon, Francoise Trichopoulou, Antonia

Abstract

Objective: To compare the average out-of-home (OH) consumption of foods and beverages, as well as energy intake, among populations from 10 European countries and to describe the characteristics of substantial OH caters, as defined for the purpose of the present study, in comparison to other individuals. Design: Cross-sectional study. Dietary data were collected through single 24-hour dietary recalls, in which the place of consumption was recorded. For the present study, substantial OH eaters were defined as those who consumed more than 25% of total daily energy intake at locations other than the household premises. Mean dietary intakes and the proportion of substantial OH eaters are presented by food group and country. Logistic regression analyses were used to estimate the odds of being a substantial OH eater in comparison to not being one, using mutually adjusted possible non-dietary determinants. Setting: Ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Subjects: The subjects were 34 270 individuals, 12 537 men and 21733 women, aged 35-74 years. Results: The fraction of energy intake during OH eating was generally higher in northern European countries than in the southern ones. Among the food and beverage groups, those selectively consumed outside the home were coffee/tea/waters and sweets and, to a lesser extent, cereals, meats, added lipids and vegetables. Substantial OH eating was positively associated with energy intake and inversely associated with age and physical activity. Substantial OH eating was less common among the less educated compared with the more educated, and more common during weekdays in central and north Europe and during the weekend in south Europe. Conclusions: Eating outside the home was associated with sedentary lifestyle and increased energy intake; it was more common among the young and concerned in particular coffee/tea/waters and sweets.

Published
2007

72. Identification of Urinary Polyphenol Metabolite Patterns Associated with Polyphenol-Rich Food Intake in Adults from Four European Countries.

Author

Hwayoung Noh, Freisling, Heinz, Assi, Nada, Zamora-Ros, Raul, Achaintre, David, Affret, Aurélie, Mancini, Francesca, Boutron-Ruault, Marie-Christine, Flögel, Anna, Boeing, Heiner, Kühn, Tilman, Schübel, Ruth, Trichopoulou, Antonia, Naska, Androniki, Kritikou, Maria, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Ricceri, Fulvio, and De Magistris, Maria Santucci

Abstract

We identified urinary polyphenol metabolite patterns by a novel algorithm that combines dimension reduction and variable selection methods to explain polyphenol-rich food intake, and compared their respective performance with that of single biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 475 adults from four European countries (Germany, France, Italy, and Greece). Dietary intakes were assessed with 24-h dietary recalls (24-HDR) and dietary questionnaires (DQ). Thirty-four polyphenols were measured by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS-MS) in 24-h urine. Reduced rank regression-based variable importance in projection (RRR-VIP) and least absolute shrinkage and selection operator (LASSO) methods were used to select polyphenol metabolites. Reduced rank regression (RRR) was then used to identify patterns in these metabolites, maximizing the explained variability in intake of pre-selected polyphenol-rich foods. The performance of RRR models was evaluated using internal cross-validation to control for over-optimistic findings from over-fitting. High performance was observed for explaining recent intake (24-HDR) of red wine (r = 0.65; AUC = 89.1%), coffee (r = 0.51; AUC = 89.1%), and olives (r = 0.35; AUC = 82.2%). These metabolite patterns performed better or equally well compared to single polyphenol biomarkers. Neither metabolite patterns nor single biomarkers performed well in explaining habitual intake (as reported in the DQ) of polyphenol-rich foods. This proposed strategy of biomarker pattern identification has the potential of expanding the currently still limited list of available dietary intake biomarkers. [ABSTRACT FROM AUTHOR]

Published
2017
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73. Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study

Author

Moskal, Aurelie, primary, Pisa, Pedro T., additional, Ferrari, Pietro, additional, Byrnes, Graham, additional, Freisling, Heinz, additional, Boutron-Ruault, Marie-Christine, additional, Cadeau, Claire, additional, Nailler, Laura, additional, Wendt, Andrea, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Buijsse, Brian, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Dahm, Christina C., additional, Chiuve, Stephanie E., additional, Quirós, Jose R., additional, Buckland, Genevieve, additional, Molina-Montes, Esther, additional, Amiano, Pilar, additional, Huerta Castaño, José M., additional, Gurrea, Aurelio Barricarte, additional, Khaw, Kay-Tee, additional, Lentjes, Marleen A., additional, Key, Timothy J., additional, Romaguera, Dora, additional, Vergnaud, Anne-Claire, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Orfanos, Philippos, additional, Palli, Domenico, additional, Pala, Valeria, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, de Magistris, Maria Santucci, additional, Bueno-de-Mesquita, H. Bas, additional, Ocké, Marga C., additional, Beulens, Joline W. J., additional, Ericson, Ulrika, additional, Drake, Isabel, additional, Nilsson, Lena M., additional, Winkvist, Anna, additional, Weiderpass, Elisabete, additional, Hjartåker, Anette, additional, Riboli, Elio, additional, and Slimani, Nadia, additional

Published
2014
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74. Fish consumption and subsequent change in body weight in European women and men

Author

Jakobsen, Marianne U., Dethlefsen, Claus, Due, Karen M., May, Anne M., Romaguera, Dora, Vergnaud, Anne-Claire, Norat, Teresa, Sorensen, Thorkild I. A., Halkjaer, Jytte, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Fagherazzi, Guy, Teucher, Birgit, Kuehn, Tilman, Bergmann, Manuela M., Boeing, Heiner, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Palli, Domenico, De Magistris, Maria Santucci, Sieri, Sabina, Bueno-de-Mesquita, H. B., van der A, Daphne L., Engeset, Dagrun, Hjartaker, Anette, Rodriguez, Laudina, Agudo, Antonio, Molina-Montes, Esther, Huerta, Jose M., Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfalt, Elisabet, Hallmans, Göran, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Timothy J., Chajes, Veronique, Slimani, Nadia, Riboli, Elio, Peeters, Petra H. M., Overvad, Kim, Jakobsen, Marianne U., Dethlefsen, Claus, Due, Karen M., May, Anne M., Romaguera, Dora, Vergnaud, Anne-Claire, Norat, Teresa, Sorensen, Thorkild I. A., Halkjaer, Jytte, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Fagherazzi, Guy, Teucher, Birgit, Kuehn, Tilman, Bergmann, Manuela M., Boeing, Heiner, Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Palli, Domenico, De Magistris, Maria Santucci, Sieri, Sabina, Bueno-de-Mesquita, H. B., van der A, Daphne L., Engeset, Dagrun, Hjartaker, Anette, Rodriguez, Laudina, Agudo, Antonio, Molina-Montes, Esther, Huerta, Jose M., Barricarte, Aurelio, Amiano, Pilar, Manjer, Jonas, Wirfalt, Elisabet, Hallmans, Göran, Johansson, Ingegerd, Khaw, Kay-Tee, Wareham, Nicholas J., Key, Timothy J., Chajes, Veronique, Slimani, Nadia, Riboli, Elio, Peeters, Petra H. M., and Overvad, Kim

Abstract

Fish consumption is the major dietary source of EPA and DHA, which according to rodent experiments may reduce body fat mass and prevent obesity. Only a few human studies have investigated the association between fish consumption and body-weight gain. We investigated the association between fish consumption and subsequent change in body weight. Women and men (n 344 757) participating in the European Prospective Investigation into Cancer and Nutrition were followed for a median of 5.0 years. Linear and logistic regression were used to investigate the associations between fish consumption and subsequent change in body weight. Among women, the annual weight change was 5.70 (95% CI 4.35, 7.06), 2.23 (95% CI 0.16, 4.31) and 11.12 (95% CI 8.17, 14.08) g/10 g higher total, lean and fatty fish consumption per d, respectively. The OR of becoming overweight in 5 years among women who were normal weight at enrolment was 1.02 (95% CI 1.01, 1.02), 1.01 (95% CI 1.00, 1.02) and 1.02 (95% CI 1.01, 1.04) g/10 g higher total, lean and fatty consumption per d, respectively. Among men, fish consumption was not statistically significantly associated with weight change. Adjustment for potential over-or underestimation of fish consumption did not systematically change the observed associations, but the 95% CI became wider. The results in subgroups from analyses stratified by age or BMI at enrolment were not systematically different. In conclusion, the present study suggests that fish consumption has no appreciable association with body-weight gain.

Published
2013
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75. Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Knaze, Viktoria, Lujan-Barroso, Leila, Romieu, Isabelle, Scalbert, Augustin, Slimani, Nadia, Hjartaker, Anette, Engeset, Dagrun, Skeie, Guri, Overvad, Kim, Bredsdorff, Lea, Tjonneland, Anne, Halkjaer, Jytte, Key, Timothy J, Khaw, Kay-Tee, Mulligan, Angela A, Winkvist, Anna, Johansson, Ingegerd, Bueno-de-Mesquita, H Bas, Peeters, Petra HM, Wallström, Peter, Ericson, Ulrika, Pala, Valeria, de Magistris, Maria Santucci, Polidoro, Silvia, Tumino, Rosario, Trichopoulou, Antonia, Dilis, Vardis, Katsoulis, Michael, Maria Huerta, Jose, Martinez, Virginia, Sanchez, Maria-Jose, Ardanaz, Eva, Amiano, Pilar, Teucher, Birgit, Grote, Verena, Bendinelli, Benedetta, Boeing, Heiner, Foerster, Jana, Touillaud, Marina, Perquier, Florence, Fagherazzi, Guy, Gallo, Valentina, Riboli, Elio, Gonzalez, Carlos A, Zamora-Ros, Raul, Knaze, Viktoria, Lujan-Barroso, Leila, Romieu, Isabelle, Scalbert, Augustin, Slimani, Nadia, Hjartaker, Anette, Engeset, Dagrun, Skeie, Guri, Overvad, Kim, Bredsdorff, Lea, Tjonneland, Anne, Halkjaer, Jytte, Key, Timothy J, Khaw, Kay-Tee, Mulligan, Angela A, Winkvist, Anna, Johansson, Ingegerd, Bueno-de-Mesquita, H Bas, Peeters, Petra HM, Wallström, Peter, Ericson, Ulrika, Pala, Valeria, de Magistris, Maria Santucci, Polidoro, Silvia, Tumino, Rosario, Trichopoulou, Antonia, Dilis, Vardis, Katsoulis, Michael, Maria Huerta, Jose, Martinez, Virginia, Sanchez, Maria-Jose, Ardanaz, Eva, Amiano, Pilar, Teucher, Birgit, Grote, Verena, Bendinelli, Benedetta, Boeing, Heiner, Foerster, Jana, Touillaud, Marina, Perquier, Florence, Fagherazzi, Guy, Gallo, Valentina, Riboli, Elio, and Gonzalez, Carlos A

Abstract

A greater adherence to the traditional Mediterranean (MED) diet is associated with a reduced risk of developing chronic diseases. This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED and non-MED countries participating in the EPIC study. Flavonoid intakes and their food sources for 35 628 subjects, aged 35-74 years and recruited between 1992 and 2000, in twenty-six study centres were estimated using standardised 24 h dietary recall software (EPIC-Soft (R)). An ad hoc food composition database on flavonoids was compiled using analytical data from the United States Department of Agriculture and Phenol-Explorer databases. Moreover, it was expanded to include using recipes, estimations of missing values and flavonoid retention factors. No significant differences in total flavonoid mean intake between non-MED countries (373.7 mg/d) and MED countries (370.2 mg/d) were observed. In the non-MED region, the main contributors were proanthocyanidins (48.2 %) and flavan-3-ol monomers (24.9 %) and the principal food sources were tea (25.7 %) and fruits (32.8 %). In the MED region, proanthocyanidins (59.0 %) were by far the most abundant contributor and fruits (55.1 %), wines (16.7 %) and tea (6.8 %) were the main food sources. The present study shows similar results for total dietary flavonoid intakes, but significant differences in flavonoid class intakes, food sources and some characteristics between MED and non-MED countries. These differences should be considered in studies about the relationships between flavonoid intake and chronic diseases.

Published
2013
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76. Ecological-level associations between highly processed food intakes and plasma phospholipid elaidic acid concentrations : results from a cross-sectional study within the European prospective investigation into cancer and nutrition (EPIC).

Author

Chajès, Véronique, Biessy, Carine, Byrnes, Graham, Deharveng, Geneviève, Saadatian-Elahi, Mitra, Jenab, Mazda, Peeters, Petra H M, Ocké, Marga, Bueno-de-Mesquita, H Bas, Johansson, Ingegerd, Hallmans, Göran, Manjer, Jonas, Wirfält, Elisabet, Jakszyn, Paula, González, Carlos A, Huerta, Jose-Maria, Martinez, Carmen, Amiano, Pilar, Suárez, Laudina Rodriguez, Ardanaz, Eva, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Jakobsen, Marianne Uhre, Berrino, Franco, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, de Magistris, Maria Santucci, Spencer, Elisabeth A, Crowe, Francesca L, Bingham, Sheila, Khaw, Kay-Tee, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Nöethlings, Ute, Olsen, Karina Standahl, Skeie, Guri, Lund, Eiliv, Trichopoulou, Antonia, Zilis, Dimosthenis, Oustoglou, Erifili, Clavel-Chapelon, Françoise, Riboli, Elio, Slimani, Nadia, Chajès, Véronique, Biessy, Carine, Byrnes, Graham, Deharveng, Geneviève, Saadatian-Elahi, Mitra, Jenab, Mazda, Peeters, Petra H M, Ocké, Marga, Bueno-de-Mesquita, H Bas, Johansson, Ingegerd, Hallmans, Göran, Manjer, Jonas, Wirfält, Elisabet, Jakszyn, Paula, González, Carlos A, Huerta, Jose-Maria, Martinez, Carmen, Amiano, Pilar, Suárez, Laudina Rodriguez, Ardanaz, Eva, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Jakobsen, Marianne Uhre, Berrino, Franco, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, de Magistris, Maria Santucci, Spencer, Elisabeth A, Crowe, Francesca L, Bingham, Sheila, Khaw, Kay-Tee, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Nöethlings, Ute, Olsen, Karina Standahl, Skeie, Guri, Lund, Eiliv, Trichopoulou, Antonia, Zilis, Dimosthenis, Oustoglou, Erifili, Clavel-Chapelon, Françoise, Riboli, Elio, and Slimani, Nadia

Abstract

Elaidic acid is the main unnatural trans fatty acid isomer occurring during partial hydrogenation of vegetable oils used as ingredients for the formulation of processed foods. The main objective is to assess associations between processed food intakes and plasma phospholipid elaidic acid concentrations within the European Prospective Investigation into Cancer and Nutrition study. A cross-sectional study was used to determine fatty acid profiles in 3,003 subjects from 16 centers. Single 24-h dietary recalls (24-HDR) were collected using a standardized computerized interview program. Food intakes were computed according to their degree of processing (moderately/nonprocessed foods, processed staple foods, highly processed foods). Adjusted ecological and individual correlations were calculated between processed food intakes and plasma elaidic acid levels. At the population level, mean intakes of highly processed foods were strongly correlated with mean levels of plasma elaidic acid in men (P = 0.0016) and in women (P = 0.0012). At the individual level, these associations remained but at a much lower level in men (r = 0.08, P = 0.006) and in women (r = 0.09, P = 0.0001). The use of an averaged 24-HDR measure of highly processed food intakes is adequate for predicting mean levels of plasma elaidic acid among European populations.

Published
2011
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77. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort

Author

Zamora-Ros, Raul, Knaze, Viktoria, Lujan-Barroso, Leila, Slimani, Nadia, Romieu, Isabelle, Fedirko, Veronika, de Magistris, Maria Santucci, Ericson, Ulrica, Amiano, Pilar, Trichopoulou, Antonia, Dilis, Vardis, Naska, Androniki, Engeset, Dagrun, Skeie, Guri, Cassidy, Aedin, Overvad, Kim, Peeters, Petra H. M., Maria Huerta, Jose, Sanchez, Maria-Jose, Ramon Quiros, J., Sacerdote, Carlotta, Grioni, Sara, Tumino, Rosario, Johansson, Gerd, Johansson, Ingegerd, Drake, Isabel, Crowe, Francesca L., Barricarte, Aurelio, Kaaks, Rudolf, Teucher, Birgit, Bueno-de-Mesquita, H. Bas, van Rossum, Caroline T. M., Norat, Teresa, Romaguera, Dora, Vergnaud, Anne-Claire, Tjonneland, Anne, Halkjaer, Jytte, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Salvini, Simonetta, Khaw, Kay-Thee, Wareham, Nicholas, Boeing, Heiner, Foerster, Jana, Riboli, Elio, Gonzalez, Carlos A., Zamora-Ros, Raul, Knaze, Viktoria, Lujan-Barroso, Leila, Slimani, Nadia, Romieu, Isabelle, Fedirko, Veronika, de Magistris, Maria Santucci, Ericson, Ulrica, Amiano, Pilar, Trichopoulou, Antonia, Dilis, Vardis, Naska, Androniki, Engeset, Dagrun, Skeie, Guri, Cassidy, Aedin, Overvad, Kim, Peeters, Petra H. M., Maria Huerta, Jose, Sanchez, Maria-Jose, Ramon Quiros, J., Sacerdote, Carlotta, Grioni, Sara, Tumino, Rosario, Johansson, Gerd, Johansson, Ingegerd, Drake, Isabel, Crowe, Francesca L., Barricarte, Aurelio, Kaaks, Rudolf, Teucher, Birgit, Bueno-de-Mesquita, H. Bas, van Rossum, Caroline T. M., Norat, Teresa, Romaguera, Dora, Vergnaud, Anne-Claire, Tjonneland, Anne, Halkjaer, Jytte, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Salvini, Simonetta, Khaw, Kay-Thee, Wareham, Nicholas, Boeing, Heiner, Foerster, Jana, Riboli, Elio, and Gonzalez, Carlos A.

Abstract

Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo. We aimed to estimate the FLAV dietary intake, their food sources and associated lifestyle factors in ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. FLAV intake and their food sources for 36 037 subjects, aged between 35 and 74 years, in twenty-seven study centres were obtained using standardised 24 h dietary recall software (EPIC-SOFT). An ad hoc food composition database on FLAV was compiled using data from US Department of Agriculture and Phenol-Explorer databases and was expanded using recipes, estimations and flavonoid retention factors in order to increase its correspondence with the 24 h dietary recall. Our results showed that the highest FLAV-consuming centre was the UK health-conscious group, with 130.9 and 97.0 mg/d for men and women, respectively. The lowest FLAV intakes were 36.8 mg/d in men from Umea and 37.2 mg/d in women from Malmo (Sweden). The flavanone sub-class was the main contributor to the total FLAV intake ranging from 46.6 to 52.9% depending on the region. Flavonols ranged from 38.5 to 47.3% and flavones from 5.8 to 8.6%. FLAV intake was higher in women, non-smokers, increased with level of education and physical activity. The major food sources were citrus fruits and citrus-based juices (especially for flavanones), tea, wine, other fruits and some vegetables. We concluded that the present study shows heterogeneity in intake of these three sub-classes of flavonoids across European regions and highlights differences by sex and other sociodemographic and lifestyle factors.

Published
2011
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78. Dietary intakes and food sources of phenolic acids in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, primary, Rothwell, Joseph A., additional, Scalbert, Augustin, additional, Knaze, Viktoria, additional, Romieu, Isabelle, additional, Slimani, Nadia, additional, Fagherazzi, Guy, additional, Perquier, Florence, additional, Touillaud, Marina, additional, Molina-Montes, Esther, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Menéndez, Virginia, additional, Tumino, Rosario, additional, de Magistris, Maria Santucci, additional, Palli, Domenico, additional, Ricceri, Fulvio, additional, Sieri, Sabina, additional, Crowe, Francesca L., additional, Khaw, Kay-Thee, additional, Wareham, Nicholas J., additional, Grote, Verena, additional, Li, Kuanrong, additional, Boeing, Heiner, additional, Förster, Jana, additional, Trichopoulou, Antonia, additional, Benetou, Vassiliki, additional, Tsiotas, Konstantinos, additional, Bueno-de-Mesquita, H. Bas, additional, Ros, Martine, additional, Peeters, Petra H. M., additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Overvad, Kim, additional, Ericson, Ulrika, additional, Wallström, Peter, additional, Johansson, Ingegerd, additional, Landberg, Rikard, additional, Weiderpass, Elisabete, additional, Engeset, Dagrun, additional, Skeie, Guri, additional, Wark, Petra, additional, Riboli, Elio, additional, and González, Carlos A., additional

Published
2013
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79. North–south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author

Eussen, Simone J. P. M., primary, Nilsen, Roy M., additional, Midttun, Øivind, additional, Hustad, Steinar, additional, IJssennagger, Noortje, additional, Meyer, Klaus, additional, Fredriksen, Åse, additional, Ulvik, Arve, additional, Ueland, Per M., additional, Brennan, Paul, additional, Johansson, Mattias, additional, Bueno-de-Mesquita, Bas, additional, Vineis, Paolo, additional, Chuang, Shu-Chun, additional, Boutron-Ruault, Marie Christine, additional, Dossus, Laure, additional, Perquier, Florence, additional, Overvad, Kim, additional, Teucher, Birgit, additional, Grote, Verena A., additional, Trichopoulou, Antonia, additional, Adarakis, George, additional, Plada, Maria, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, de Magistris, Maria Santucci, additional, Ros, Martine M., additional, Peeters, Petra H. M., additional, Redondo, Maria Luisa, additional, Zamora-Ros, Raul, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Sonestedt, Emily, additional, Ericson, Ulrika, additional, Schneede, Jörn, additional, van Guelpen, Bethany, additional, Wark, Petra A., additional, Gallo, Valentina, additional, Norat, Teresa, additional, Riboli, Elio, additional, and Vollset, Stein Emil, additional

Published
2012
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80. Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, primary, Knaze, Viktoria, additional, Luján-Barroso, Leila, additional, Romieu, Isabelle, additional, Scalbert, Augustin, additional, Slimani, Nadia, additional, Hjartåker, Anette, additional, Engeset, Dagrun, additional, Skeie, Guri, additional, Overvad, Kim, additional, Bredsdorff, Lea, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Key, Timothy J., additional, Khaw, Kay-Tee, additional, Mulligan, Angela A., additional, Winkvist, Anna, additional, Johansson, Ingegerd, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H. M., additional, Wallström, Peter, additional, Ericson, Ulrika, additional, Pala, Valeria, additional, de Magistris, Maria Santucci, additional, Polidoro, Silvia, additional, Tumino, Rosario, additional, Trichopoulou, Antonia, additional, Dilis, Vardis, additional, Katsoulis, Michael, additional, María Huerta, José, additional, Martínez, Virginia, additional, Sánchez, María-José, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Teucher, Birgit, additional, Grote, Verena, additional, Bendinelli, Benedetta, additional, Boeing, Heiner, additional, Förster, Jana, additional, Touillaud, Marina, additional, Perquier, Florence, additional, Fagherazzi, Guy, additional, Gallo, Valentina, additional, Riboli, Elio, additional, and González, Carlos A., additional

Published
2012
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81. Ecological-Level Associations Between Highly Processed Food Intakes and Plasma Phospholipid Elaidic Acid Concentrations: Results From a Cross-Sectional Study Within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Author

Chajès, Véronique, primary, Biessy, Carine, additional, Byrnes, Graham, additional, Deharveng, Geneviève, additional, Saadatian-Elahi, Mitra, additional, Jenab, Mazda, additional, Peeters, Petra H. M., additional, Ocké, Marga, additional, Bueno-de-Mesquita, H. Bas, additional, Johansson, Ingegerd, additional, Hallmans, Göran, additional, Manjer, Jonas, additional, Wirfält, Elisabet, additional, Jakszyn, Paula, additional, González, Carlos A., additional, Huerta, Jose-Maria, additional, Martinez, Carmen, additional, Amiano, Pilar, additional, Suárez, Laudina Rodriguez, additional, Ardanaz, Eva, additional, Tjønneland, Anne, additional, Halkjaer, Jytte, additional, Overvad, Kim, additional, Jakobsen, Marianne Uhre, additional, Berrino, Franco, additional, Pala, Valeria, additional, Palli, Domenico, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, de Magistris, Maria Santucci, additional, Spencer, Elisabeth A., additional, Crowe, Francesca L., additional, Bingham, Sheila, additional, Khaw, Kay-Tee, additional, Linseisen, Jakob, additional, Rohrmann, Sabine, additional, Boeing, Heiner, additional, Nöethlings, Ute, additional, Olsen, Karina Standahl, additional, Skeie, Guri, additional, Lund, Eiliv, additional, Trichopoulou, Antonia, additional, Zilis, Dimosthenis, additional, Oustoglou, Erifili, additional, Clavel-Chapelon, Françoise, additional, Riboli, Elio, additional, and Slimani, Nadia, additional

Published
2011
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82. Relationship between Plasma Fatty Acid Composition and Diet over Previous Years in the Italian Centers of the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Fusconi, Elisabetta, primary, Pala, Valeria, additional, Riboli, Elio, additional, Vineis, Paolo, additional, Sacerdote, Carlotta, additional, Del Pezzo, Mariarosaria, additional, de Magistris, Maria Santucci, additional, Palli, Domenico, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Foggetti, Carmela Eugenia, additional, Giurdanella, Maria Concetta, additional, Tumino, Rosario, additional, and Krogh, Vittorio, additional

Published
2003
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83. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Author

Moskal, Aurélie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T, Jenab, Mazda, Ferrari, Pietro, Tjønneland, Anne, Petersen, Kristina En, Dahm, Christina C, Hansen, Camilla Plambeck, Affret, Aurélie, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Kühn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, De Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H, Bueno-De-Mesquita, Bas H, Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Castaño, José M Huerta, Quirós, José R, Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay-Tee, Huybrechts, Inge, Tsilidis, Konstantinos K, Ward, Heather, Gunter, Marc J, and Slimani, Nadia

Subjects
2. Zero hunger, Adult, Europe, Male, Risk Factors, Humans, Nutritional Status, Female, Prospective Studies, Middle Aged, Colorectal Neoplasms, 3. Good health
Abstract

BACKGROUND: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors. RESULTS: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk. CONCLUSIONS: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

84. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries

Author

Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda MA, Verschuren, WM Monique, Van Der Schouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, and Touvier, Mathilde

Subjects
2. Zero hunger, Research, 3. Good health
Abstract

Objective: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design: Population based cohort study. Setting: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, P

85. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study

Author

Zheng, Ju-Sheng, Sharp, Stephen J, Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B, Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T, Fagherazzi, Guy, Franks, Paul W, Feskens, Edith JM, Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J, Khaw, Kay-Tee, De Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M, Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke MW, Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, Van Der Schouw, Yvonne T, Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G, and Wareham, Nicholas J

Subjects
Adult, Blood Glucose, Male, Body Mass Index, Young Adult, Hepatic, Humans, Saturated fatty acids, Prospective Studies, Triglycerides, Aged, 2. Zero hunger, Inflammation, Cholesterol, HDL, Fatty Acids, Cholesterol, LDL, Middle Aged, Lipids, Dietary Fats, 3. Good health, Europe, Metabolic markers, Cross-Sectional Studies, Even-chain, lipids (amino acids, peptides, and proteins), Female, Very-long-chain, Glycaemic, Odd-chain, Biomarkers
Abstract

BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. METHODS: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. RESULTS: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. CONCLUSIONS: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.

86. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries

Author

Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda Ma, Verschuren, Wm Monique, Van Der Schouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, and Touvier, Mathilde

Subjects
2. Zero hunger, Adult, Male, Middle Aged, 3. Good health, Cohort Studies, Europe, Food Preferences, Nutrition Assessment, Food Labeling, Surveys and Questionnaires, Humans, Female, Mortality, Nutritive Value, Proportional Hazards Models
Abstract

OBJECTIVE: To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. DESIGN: Population based cohort study. SETTING: European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. PARTICIPANTS: 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. MAIN OUTCOME MEASURE: Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. RESULTS: After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, P

87. [Dietary habits and cardiovascular disease: the experience of EPIC Italian collaboration]

Author

Amalia Mattiello, Chiodini, Paolo, Magistris, Maria Santucci, Krogh, Vittorio, Grioni, Sara, Fasanelli, Francesca, Vineis, Paolo, Saieva, Calogero, Bendinelli, Benedetta, Frasca, Graziella, Giurdanella, Maria Concetta, Panico, Salvatore, Mattiello, Amalia, Chiodini, Paolo, De Magistris, Maria Santucci, Krogh, Vittorio, Grioni, Sara, Fasanelli, Francesco, Vineis, Paolo, Saieva, Calogero, Bendinelli, Benedetto, Fresco, Graziella, Giurdanella, Maria Concetta, Panico, Salvatore, Santucci de Magistris, Maria, Fasanelli, Francesca, Bendinelli, Benedetta, and Frasca, Graziella

Subjects
Coronary heart disease, Cerebrovascular disease, Epic, Diet
Abstract

OBJECTIVES: To report and evaluate the evidence produced by the EPIC Italian collaboration (EPICOR Project) on the dietary determinants of cardiovascular diseases in Italy. DESIGN: prospective study carried out in a large Italian population, composed by cohorts recruited in Northern, Central and Southern Italy. SETTING AND PARTICIPANTS: data on dietary habits collected at the baseline observation through standardised questionnaires on 47,749 free-living adults at the time of the recruitment of the study (1993-1998). MAIN OUTCOME MEASURES: major coronary and cerebrovascular events (acute coronary syndrome, PTCA, CABG, ischemic and haemor- rhagic stroke, TEA of supraortic vessels) identified at follow-up. The longitudinal analyses here reported have measured risks through the use of multivariate Cox regression models, adjusted for potential confounders. RESULTS: The longitudinal analyses of EPICOR indicate that Mediter- ranean-oriented dietary habits, measured through specific indicators and the consumption of various typical food, are able to reduce coronary and cerebrovascular risks, and that this protection is possible even nowadays, although many changes in diet have occurred in the last decades in Italy. Habitual consumption of plant origin products, including all foods with low glycemic index, is an advantage for cardiovascular risk. CONCLUSIONS: The EPICOR Project is the largest, long-lasting Italian study on the relationship between diet and cardiovascular diseases. It is also the study with the greater number of observed variables. Its results point out the importance to support preventive programmes and industrial policies able to favour a dietary style inspired to the Italian Mediterranean tradition.

88. Pre-diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study.

Author

Pham TT, Nimptsch K, Aleksandrova K, Jenab M, Fedirko V, Wu K, Eriksen AK, Tjønneland A, Severi G, Rothwell J, Kaaks R, Katzke V, Catalano A, Agnoli C, Masala G, De Magistris MS, Tumino R, Vermeulen R, Aizpurua A, Trobajo-Sanmartín C, Chirlaque MD, Sánchez MJ, Lu SSM, Cross AJ, Christakoudi S, Weiderpass E, and Pischon T

Subjects
Humans, Prospective Studies, Proportional Hazards Models, Body Mass Index, Risk Factors, Resistin, Colorectal Neoplasms
Abstract

Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre-diagnostic serum resistin concentrations in relation to CRC-specific and all-cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC-specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause-specific Cox proportional hazards models and further in sensitivity analyses using Fine-Gray proportional subdistribution hazards models. For all-cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow-up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC-specific mortality (HR Q4vsQ1  = 0.95, 95% CI: 0.73-1.23; P trend  = .97; and HR per doubling of resistin concentration  = 1.00; 95% CI: 0.84-1.19; P = .98) or all-cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre-diagnostic circulating resistin concentrations and CRC-specific or all-cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression., (© 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)

Published
2024
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89. Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients.

Author

Mao Z, Baker JR, Takeuchi M, Hyogo H, Tjønneland A, Eriksen AK, Severi G, Rothwell J, Laouali N, Katzke V, Kaaks R, Schulze MB, Palli D, Sieri S, de Magistris MS, Tumino R, Sacerdote C, Derksen JWG, Gram IT, Skeie G, Sandanger TM, Quirós JR, Crous-Bou M, Sánchez MJ, Amiano P, Colorado-Yohar SM, Guevara M, Harlid S, Johansson I, Perez-Cornago A, Freisling H, Gunter M, Weiderpass E, Heath AK, Aglago E, Jenab M, and Fedirko V

Subjects
Humans, Glyceraldehyde, Prospective Studies, Body Mass Index, Glycation End Products, Advanced, Colorectal Neoplasms
Abstract

Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HR Q5 vs Q1  = 1.53, 95% CI: 1.04-2.25, P trend  = .002) and all-cause (HR Q5 vs Q1  = 1.62, 95% CI: 1.16-2.26, P trend  < .001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HR proximal colon  = 1.02, 95% CI: 0.74-1.42; HR distal colon  = 1.51, 95% CI: 1.20-1.91; P effect modification  = .02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted., (© 2023 UICC.)

Published
2023
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90. Changes in Lifestyle and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition.

Author

Botteri E, Peveri G, Berstad P, Bagnardi V, Chen SLF, Sandanger TM, Hoff G, Dahm CC, Antoniussen CS, Tjønneland A, Eriksen AK, Skeie G, Perez-Cornago A, Huerta JM, Jakszyn P, Harlid S, Sundström B, Barricarte A, Monninkhof EM, Derksen JWG, Schulze MB, Bueno-de-Mesquita B, Sánchez MJ, Cross AJ, Tsilidis KK, De Magistris MS, Kaaks R, Katzke V, Rothwell JA, Laouali N, Severi G, Amiano P, Contiero P, Sacerdote C, Goldberg M, Touvier M, Freisling H, Viallon V, Weiderpass E, Riboli E, Gunter MJ, Jenab M, and Ferrari P

Subjects
Humans, Risk Factors, Prospective Studies, Nutritional Status, Life Style, Colorectal Neoplasms epidemiology, Colorectal Neoplasms prevention & control
Abstract

Introduction: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort., Methods: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95% confidence intervals (CI)., Results: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI ≤ 9) had a higher CRC risk (HR 1.34; 95% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95% CI 0.59-1.00) than those remaining in the bottom tertile., Discussion: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention., (Copyright © 2022 by The American College of Gastroenterology.)

Published
2023
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91. A treelet transform analysis to relate nutrient patterns to the risk of hormonal receptor-defined breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Author

Assi N, Moskal A, Slimani N, Viallon V, Chajes V, Freisling H, Monni S, Knueppel S, Förster J, Weiderpass E, Lujan-Barroso L, Amiano P, Ardanaz E, Molina-Montes E, Salmerón D, Quirós JR, Olsen A, Tjønneland A, Dahm CC, Overvad K, Dossus L, Fournier A, Baglietto L, Fortner RT, Kaaks R, Trichopoulou A, Bamia C, Orfanos P, De Magistris MS, Masala G, Agnoli C, Ricceri F, Tumino R, Bueno de Mesquita HB, Bakker MF, Peeters PH, Skeie G, Braaten T, Winkvist A, Johansson I, Khaw KT, Wareham NJ, Key T, Travis R, Schmidt JA, Merritt MA, Riboli E, Romieu I, and Ferrari P

Subjects
Adult, Breast Neoplasms etiology, Breast Neoplasms metabolism, Diet Surveys, Europe, Female, Humans, Menopause, Middle Aged, Proportional Hazards Models, Risk Factors, Breast Neoplasms prevention & control, Diet, Feeding Behavior, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism
Abstract

Objective: Pattern analysis has emerged as a tool to depict the role of multiple nutrients/foods in relation to health outcomes. The present study aimed at extracting nutrient patterns with respect to breast cancer (BC) aetiology., Design: Nutrient patterns were derived with treelet transform (TT) and related to BC risk. TT was applied to twenty-three log-transformed nutrient densities from dietary questionnaires. Hazard ratios (HR) and 95 % confidence intervals computed using Cox proportional hazards models quantified the association between quintiles of nutrient pattern scores and risk of overall BC, and by hormonal receptor and menopausal status. Principal component analysis was applied for comparison., Setting: The European Prospective Investigation into Cancer and Nutrition (EPIC)., Subjects: Women (n 334 850) from the EPIC study., Results: The first TT component (TC1) highlighted a pattern rich in nutrients found in animal foods loading on cholesterol, protein, retinol, vitamins B12 and D, while the second TT component (TC2) reflected a diet rich in β-carotene, riboflavin, thiamin, vitamins C and B6, fibre, Fe, Ca, K, Mg, P and folate. While TC1 was not associated with BC risk, TC2 was inversely associated with BC risk overall (HRQ5 v. Q1=0·89, 95 % CI 0·83, 0·95, P trend<0·01) and showed a significantly lower risk in oestrogen receptor-positive (HRQ5 v. Q1=0·89, 95 % CI 0·81, 0·98, P trend=0·02) and progesterone receptor-positive tumours (HRQ5 v. Q1=0·87, 95 % CI 0·77, 0·98, P trend<0·01)., Conclusions: TT produces readily interpretable sparse components explaining similar amounts of variation as principal component analysis. Our results suggest that participants with a nutrient pattern high in micronutrients found in vegetables, fruits and cereals had a lower risk of BC.

Published
2016
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92. North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.

Author

Eussen SJ, Nilsen RM, Midttun Ø, Hustad S, IJssennagger N, Meyer K, Fredriksen Å, Ulvik A, Ueland PM, Brennan P, Johansson M, Bueno-de-Mesquita B, Vineis P, Chuang SC, Boutron-Ruault MC, Dossus L, Perquier F, Overvad K, Teucher B, Grote VA, Trichopoulou A, Adarakis G, Plada M, Sieri S, Tumino R, de Magistris MS, Ros MM, Peeters PH, Redondo ML, Zamora-Ros R, Chirlaque MD, Ardanaz E, Sonestedt E, Ericson U, Schneede J, van Guelpen B, Wark PA, Gallo V, Norat T, Riboli E, and Vollset SE

Subjects
Adult, Aged, Alcohol Drinking ethnology, Chronic Disease ethnology, Ethnicity, Europe, Female, Humans, Male, Middle Aged, Prospective Studies, Sex Factors, Smoking ethnology, Folic Acid blood, Glycine blood, Health Behavior ethnology, Life Style ethnology, Sarcosine blood, Serine blood, Vitamin B 12 blood
Abstract

Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10·4 nmol/l; women, 10·7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B₂ concentrations were highest in Northern Europe (men, 22·2 nmol/l; women, 26·0 nmol/l) and decreased towards Southern Europe (P trend< 0·001). Vitamin B(6) concentrations were highest in Central Europe in men (77·3 nmol/l) and highest in the North among women (70·4 nmol/l), with decreasing concentrations towards Southern Europe in women (P trend< 0·001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.

Published
2013
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93. Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Author

Zamora-Ros R, Knaze V, Luján-Barroso L, Romieu I, Scalbert A, Slimani N, Hjartåker A, Engeset D, Skeie G, Overvad K, Bredsdorff L, Tjønneland A, Halkjær J, Key TJ, Khaw KT, Mulligan AA, Winkvist A, Johansson I, Bueno-de-Mesquita HB, Peeters PH, Wallström P, Ericson U, Pala V, de Magistris MS, Polidoro S, Tumino R, Trichopoulou A, Dilis V, Katsoulis M, Huerta JM, Martínez V, Sánchez MJ, Ardanaz E, Amiano P, Teucher B, Grote V, Bendinelli B, Boeing H, Förster J, Touillaud M, Perquier F, Fagherazzi G, Gallo V, Riboli E, and González CA

Subjects
Adult, Aged, Diet, Mediterranean, Europe, Female, Food Analysis, Fruit, Humans, Male, Mediterranean Region, Middle Aged, Tea, Wine, Diet, Flavonoids classification
Abstract

A greater adherence to the traditional Mediterranean (MED) diet is associated with a reduced risk of developing chronic diseases. This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED and non-MED countries participating in the EPIC study. Flavonoid intakes and their food sources for 35,628 subjects, aged 35-74 years and recruited between 1992 and 2000, in twenty-six study centres were estimated using standardised 24 h dietary recall software (EPIC-Soft®). An ad hoc food composition database on flavonoids was compiled using analytical data from the United States Department of Agriculture and Phenol-Explorer databases. Moreover, it was expanded to include using recipes, estimations of missing values and flavonoid retention factors. No significant differences in total flavonoid mean intake between non-MED countries (373·7 mg/d) and MED countries (370·2 mg/d) were observed. In the non-MED region, the main contributors were proanthocyanidins (48·2%) and flavan-3-ol monomers (24·9%) and the principal food sources were tea (25·7%) and fruits (32·8%). In the MED region, proanthocyanidins (59·0%) were by far the most abundant contributor and fruits (55·1%), wines (16·7%) and tea (6·8%) were the main food sources. The present study shows similar results for total dietary flavonoid intakes, but significant differences in flavonoid class intakes, food sources and some characteristics between MED and non-MED countries. These differences should be considered in studies about the relationships between flavonoid intake and chronic diseases.

Published
2013
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94. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort.

Author

Zamora-Ros R, Knaze V, Luján-Barroso L, Slimani N, Romieu I, Fedirko V, de Magistris MS, Ericson U, Amiano P, Trichopoulou A, Dilis V, Naska A, Engeset D, Skeie G, Cassidy A, Overvad K, Peeters PH, Huerta JM, Sánchez MJ, Quirós JR, Sacerdote C, Grioni S, Tumino R, Johansson G, Johansson I, Drake I, Crowe FL, Barricarte A, Kaaks R, Teucher B, Bueno-de-Mesquita HB, van Rossum CT, Norat T, Romaguera D, Vergnaud AC, Tjønneland A, Halkjær J, Clavel-Chapelon F, Boutron-Ruault MC, Touillaud M, Salvini S, Khaw KT, Wareham N, Boeing H, Förster J, Riboli E, and González CA

Subjects
Adult, Aged, Cohort Studies, Databases, Factual, Europe, Female, Humans, Male, Middle Aged, Prospective Studies, Diet Records, Eating, Flavanones administration & dosage, Flavones administration & dosage, Flavonols administration & dosage
Abstract

Flavonols, flavanones and flavones (FLAV) are sub-classes of flavonoids that exert cardioprotective and anti-carcinogenic properties in vitro and in vivo. We aimed to estimate the FLAV dietary intake, their food sources and associated lifestyle factors in ten European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. FLAV intake and their food sources for 36 037 subjects, aged between 35 and 74 years, in twenty-seven study centres were obtained using standardised 24 h dietary recall software (EPIC-SOFT). An ad hoc food composition database on FLAV was compiled using data from US Department of Agriculture and Phenol-Explorer databases and was expanded using recipes, estimations and flavonoid retention factors in order to increase its correspondence with the 24 h dietary recall. Our results showed that the highest FLAV-consuming centre was the UK health-conscious group, with 130·9 and 97·0 mg/d for men and women, respectively. The lowest FLAV intakes were 36·8 mg/d in men from Umeå and 37·2 mg/d in women from Malmö (Sweden). The flavanone sub-class was the main contributor to the total FLAV intake ranging from 46·6 to 52·9 % depending on the region. Flavonols ranged from 38·5 to 47·3 % and flavones from 5·8 to 8·6 %. FLAV intake was higher in women, non-smokers, increased with level of education and physical activity. The major food sources were citrus fruits and citrus-based juices (especially for flavanones), tea, wine, other fruits and some vegetables. We concluded that the present study shows heterogeneity in intake of these three sub-classes of flavonoids across European regions and highlights differences by sex and other sociodemographic and lifestyle factors.

Published
2011
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