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634 results on '"De Bruijn, E."'

52. Abstracts of lectures and posters pharmaceutical and biomedical analysis meeting

Author

Ackermans, Mariëtte, Endert, Erik, Aluoch, J., Ouintens, I., Roets, E., Hoogmartens, J., Barka, G., Opper, C., Kerkdijk, H., Witte, D. T., Bruggeman, F. J., Franke, J. P., Copinga, S., Jansen, J. M., de Zeeuw, R. A., Bosman, I. J., Ensing, K., Dekker, I., Dams, Ir. A. B. J. M., de Pooter, Ch. M. J., Fichtinger-Schepman, A. M. J., Scalliet, P. G., Maes, R. A., Berends, F., Van Oosterom, A. T., de Bruijn, E. A., Fay, L. A., Verstappen, C. J., Pluijms, W., Irth, H., Oosterkamp, A. J., van der Welle, W., Khan, K., Paesen, J., Jacobs, Peter L., de Vries, Marcel P., Lammers, Norbert, Biermans, Frans, de Witte, Eric, Mussche, Philippe, Lamoree, M. H., Reinhoud, N. J., Tjaden, U. R., Niessen, W. M. A., van der Greef, J., Solie, A., Paulus, Aran, Klockow, Antje, Bruin, Gerard J. M., Reubsaet, J. L. E., Beijnen, J. H., Bult, A., Teeuwsen, J., Koster, E. H. M., Waterval, J. C. M., Underberg, W. J. M., Cypers, W., Claeys, P., Simonian, M. H., Rongen, Herman A. H., van der Horst, Helma M., Bult, Auke, van Bennekom, Wout P., Šmisterová, J., Thoithi, G., Van Schepdael, A., Wouters, K., Herdewijn, P., Vendrig, D., Gout, E., van Santvoort, P. M. J., Hamelinck, R. L. A. E., van Zeeland, M. J. M., Janssen, P. S. L., Vervoort, R. J. M., Derksen, M. W. J., Maris, F. A., Yongxin, Zhu, Hendrix, C., Busson, R., and Janssen, G.

Published
1994
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54. Abstracts of papers clinical pharmacological meeting

Author

van der Klauw, M. M., Stricker, B. H. Ch., Ottervanger, J. P., van der Meché, F. G. A., van Griensven, J. M. T., Lemkes, H. H. P. J., Kroon, J. M., Schoemaker, H. C., Cohen, A. F., Schellens, J. H. M., Loos, W., van Acker, B., de Boer-Dennert, M., Planting, A. S. T., van der Burg, M. E. L., Stoter, G., Krediet, R., Verweij, J., Blaak, E. E., van Baak, M. A., Kemerink, G. J., Pakbiers, M. T. W., Heidendal, G. A. K., Saris, W. H. M., Bouckaert, S., Vakaet, L., Dhont, M., Remon, J. P., van den Broek, S. A. J., de Graeff, P. A., van Gilst, W. H., van Veldhuisen, D. J., Hillige, H. L., Wesseling, H., Lie, K. I., Gaillard, C. A., van Es, P. N., de Leeuw, P. W., Van Bortel, L. M. A. B., Kool, M. J. F., Lustermans, F. A. T., Breed, J. G. S., Hoeks, A. P. G., Boudier, H. A. J. Struijker, Pickkers, R. P., Smits, P., Baadenhuysen, H., van 't Laar, A., Thien, Th., Elseviers, M. M., De Broe, M. E., van der Ven, A. J. A. M., Koopmans, P. P., Peters, W. H. M., Vree, T. B., van der Meer, J. W. M., Snoeck, E., Van Peer, A., Sack, M., Horton, M., Mannens, G., Woestenborghs, R., Heykants, J., Meibach, R., van Witsen, T. B., Valkenburg, H. A., Vander Stichele, R. H., De Potter, B., Vyncke, P., Bogaert, M. G., Burggraaf, J., Wollersheim, H., van Aalen, J., Schoemaker, R. G., Du, X. Y., Bax, W. A., Bos, E., Saxena, P. R., Rongen, G. A., van Heiningen, P. N. M., Schwietert, H. R., Kortboyer, J. M., Sollie, F. A. E., Piraube, C., Desché, P., Jonkman, J. H. G., Blok, W. L., Gyssens, I. C., Hekster, Y. A., Koopmans, P. P., van der Meer, J. W. M., Jansen P. A. F., Sival R. C., van Nieuwkerk J. F., Klaverwiiden B., de Bruijn, E. A., and Driessen, O.

Published
1993
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55. Neck postural stabilization, motion comfort, and impact simulation

Author

Happee, R. (author), de Bruijn, E. (author), Forbes, Patrick (author), van Drunen, P. (author), van Dieën, Jaap H. (author), van der Helm, F.C.T. (author), Happee, R. (author), de Bruijn, E. (author), Forbes, Patrick (author), van Drunen, P. (author), van Dieën, Jaap H. (author), and van der Helm, F.C.T. (author)

Abstract

The human head-neck system requires continuous muscular stabilization in the presence of gravity and trunk motion. This chapter presents experimental and modeling efforts, applying mechanical perturbations to seated subjects, evaluating trunk and head motion, to investigate postural stabilization. A detailed multisegment neck model has been developed including vestibular/visual and muscular feedback loops and cocontraction. Dynamic validation is presented in the frequency domain in all six motion directions. The neck model captures primary motion responses and interaction terms such as head rotation in response to seat translation. Results show major contributions of vestibular/visual feedback stabilizing the head in space while muscular feedback stabilizes the head on the torso. In addition, muscular feedback is essential to stabilize the individual vertebral joints and prevent neck buckling. The contribution of cocontraction is estimated to be minor in the neck. Validation in impact conditions shows that postural control parameters estimated that fitting the model to small-amplitude experimental data can predict postural responses in high-amplitude loading conditions reasonably well. This manuscript focuses on the neck but also includes experiments with combined stabilization of the complete spine, measuring trunk and head motion, with a perspective toward full spine and full-body modeling. Lumbar stabilization has been captured using a simplified model by assuming a virtual pivot around L4/L5. The model uniquely separates stabilizing contributions of intrinsic stiffness and damping (including muscle cocontraction) and muscle feedback (length, velocity, and acceleration). The model parameters allowed us to estimate the relative contributions of intrinsic and reflexive stabilization and showed intrinsic contributions, similar to or larger than reflexive contributions in lumbar stabilization with horizontal perturbations to the trunk or pelvis. Exp, Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., Intelligent Vehicles, Biomechatronics & Human-Machine Control

Published
2019
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56. Visual narrative: The 'Aeneid' woodcuts from Sebastian Brant’s edition of Virgil (Strasbourg 1502) in Thomas Murner’s translation of the 'Aeneid' (Strasbourg 1515)

Author

Besamusca, Bart, de Bruijn, Elisabeth, Willaert, Frank, Besamusca, B ( Bart ), de Bruijn, E ( Elisabeth ), Willaert, F ( Frank ), Frick, Julia; https://orcid.org/0000-0002-2938-5667, Besamusca, Bart, de Bruijn, Elisabeth, Willaert, Frank, Besamusca, B ( Bart ), de Bruijn, E ( Elisabeth ), Willaert, F ( Frank ), and Frick, Julia; https://orcid.org/0000-0002-2938-5667

Abstract

Thomas Murner’s translation of Virgil’s Aeneid into German (Strasbourg: Johann Grüninger 1515) is accompanied by a selection of 112 of the 143 Aeneid woodcuts from the complete edition of Virgil’s works edited by Sebastian Brant. The latter had been published by Johann Grüninger in Strasbourg in 1502, thirteen years before Murner’s translation. Research has demonstrated that Brant was involved in the production of the woodcuts as a “concepteur”: the extremely detailed interpretation of the text by means of images implies a thorough knowledge of Virgil’s text, while the resulting visual narrative, in addition to the textual understanding supplied by the Latin writing, creates a striking and absorbing display. It can be demonstrated that Thomas Murner knew Brant’s edition and this raises the question of whether Murner was influenced by the familiar woodcuts in his translation of the Aeneid. He, just like Brant, attributed great value not only to the illustrative and mnemonic function of the image, but also to the close relationship between the text and the image. Indeed, the influence of the Aeneid illustrations on Murner’s understanding of the Latin text can be observed in some places in his translation, demonstrating a dual translation process: the transposition of the Latin text into a pictorial form, which was then translated back into the German language.

Published
2019

57. Ritter, Romance, Rewriting. Überlegungen zur dänischen Erzählliteratur in der Frühdruckzeit am Beispiel der Historie von Persenober oc Constantianobis (1572)

Author

Besamusca, Bart, de Bruijn, Elisabeth, Willaert, Frank, Besamusca, B ( Bart ), de Bruijn, E ( Elisabeth ), Willaert, F ( Frank ), Richter, Anna Katharina; https://orcid.org/0000-0002-7165-7320, Besamusca, Bart, de Bruijn, Elisabeth, Willaert, Frank, Besamusca, B ( Bart ), de Bruijn, E ( Elisabeth ), Willaert, F ( Frank ), and Richter, Anna Katharina; https://orcid.org/0000-0002-7165-7320

Abstract

Persenober oc Constantianobis, published in 1572 by Laurentz Benedicht in Copenhagen, is an early modern Danish translation and adaption of the Old French ‘roman courtois’ Partonopeu de Blois (twelfth century). This article outlines the way in which different forms of transformation and rewriting, or Retextualisierung (Joachim Bumke), have been realized in this edition. Another, now lost, edition from 1560, as well as a manuscript in Old Danish from ca. 1500, originally derived from the Partalopa saga, which is a thirteenth- or fourteenth-century Old Norse-Icelandic prose adaption of the French romance, can be considered as precursors in this complex process of translation, adaptation and rewriting. The 1572 edition, the oldest complete Danish version in print, reveals some characteristics of paratextual and rewriting which seem to be unique in the Danish transmission: an epilogue and the transformation of an important passage (the first meeting between Persenober/Partonopeu and the princess Constantianobis/ Melior) that strengthens the importance of the moral choices of the noble protagonists. Thus, the narrative can offer both nutz und kurtzweyl (usefulness and entertainment) and models for identification to its (mostly aristocratic) readership in sixteenth-century Denmark.

Published
2019

58. Pan-cancer whole-genome analyses of metastatic solid tumours

Author

Priestley, P, Baber, J, Lolkema, Martijn, Steeghs, N, de Bruijn, E, Shale, C, Duyvesteyn, K, Haidari, S, Van Hoeck, A, Onstenk, Wendy, Roepman, P, Voda, M, Bloemendal, HJ, Tjan-Heijnen, VC, van Herpen, CM, Labots, M, Witteveen, PO, Smit, EF, Sleijfer, Stefan, Voest, EE, Cuppen, E, Priestley, P, Baber, J, Lolkema, Martijn, Steeghs, N, de Bruijn, E, Shale, C, Duyvesteyn, K, Haidari, S, Van Hoeck, A, Onstenk, Wendy, Roepman, P, Voda, M, Bloemendal, HJ, Tjan-Heijnen, VC, van Herpen, CM, Labots, M, Witteveen, PO, Smit, EF, Sleijfer, Stefan, Voest, EE, and Cuppen, E

Published
2019

59. Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

Author

Hill, Bridget T., Hosking, L. K., McClean, S., Shellard, S. A., Dempke, W. C. M., Whelan, R. D. H., Sehested, M., Friche, E., Demant, E. J. F., Jensen, P. B., Kopnin, B. P., Wolf, B., Seidel, A., Nickelsen, M., Brandt, I., Heinemann, G., Dietel, M., Bremer, S., Hoof, T., Tümmler, B., Broxterman, H. J., Versantvoort, C. H. M., Kuiper, C. M., Feller, N., Schuurhuis, G. J., Lankelma, J., Gupta, S., Tsuruo, T., Kim, C., Gollapudi, S., Bittl, A., Nap, M., Jäger, W., Lathan, B., Lang, N., Raikhlin, N. T., Perevozchikov, A. G., Volodina, J. L., Licht T., Fiebig H. H., Bross K. J., Herrmann F., Mertelsmann R., Bashir, I., Sikora, K., Foster, C. S., Castagna, M., Viacava, P., Cianfrigliao, M., Favati, A., Collecchi, P., Caligo, M. A., Cipollini, G., Bevilacqua, G., Schrenk, D., Gant, T. W., Silverman, J. A., Thorgeirsson, S. S., Harstrick, A., Zhang, Z. G., Schmoll, H. J., Rustum, Y., Mitze, M., Beck, T., Weikel, W., Brumm, C., Knapstein, P. G., McDonald, T., Gardner, P., Kang, N., van der Heyden, S. A. M., Elst, H. J., Stein, U., Jandrig, B., Krause, H., Schmidt-Peter, P., Frege, J., Wunderlich, V., Boven, E., van Kalken, C. K., Pinedo, H. M., Gebauer, W., Fallgren-Gebauer, E., Diete, M., Wagner, T., Müller, M. R., Lennartz, K., Nowrousian, H. R., Seeber, S., Shtil, A. A., Kazarov, A. R., Gudkov, A. V., Stavrovskaya, A. A., Djuraeva, F. H., Stromskaya, T. P., Noller, A., Frese, G., Neumann, M., Wilisch, A., Probst, H., Gekeler, V., Handgretinger, R., Schmidt, H., Muller, C. P., Dopfer, R., Klingebiel, T., Niethammer, D., Weger, S., Diddens, H., Daumiller, E., Bunge, A., Lilischkis, R., Salmassi, A., Kopun M., Scherthan H., Granzow C., Leuschner, I., Schmidt, D., Hoffmann, H., Harms, D., Scagliotli, G. V., Leonardo, E., Cappia, S., Esposito, G., Tombesi, M., Cianfriglia, M., Esposito, G. V., Merendino, N., Viora, M., Caserta, M., Tritarelli, E., Rocca, E., Boccoli, G., Samoggia, P., Fossati, C., Testa, U., Peschle, C., Darling, J. L., Ashmore, S. M., Peterson, D. C., Thomas, D. G. T., Kramer, R. A., Stanlunas, R., Summerhayes, T., Lion, T., Shoemaker, R. H., Wu, L., Smythe, A., Boyd, M. R., Beck, W. T., Danks, M. K., Wolverton, J. S., Chen, M., Bugg, B. Y., Suttle, D. P., Catapano, C. V., Fernandes, D. J., Gieseler, F., Boege, F., Erttmann, R., Arps, H., Zwelling, L., Wilms, K., Biersack, H., Kaspers, G. J. L., Pieters, R., Klumper, E., de Waal, F. C., van Wering, E. R., Veerman, A. J. P., Schmidt, C. A., Lorenz, F., Schäfer, A., Kirsch, A., Siegert, W., Huhn, D., Simon, W. E., Siebert, G., Schneider, M., Oettling, M., Reymann, A., Entmann, R., Schmidt, S., Woermann, C., Windmeier, C., Herzig, I., Schaefer, B., Heidebrecht, H. J., Wacker, H. H., Künnemann, H., van Heijningen, Th. H. M., Slovak, M. L., Baak, J. P. A., Steidtmann, K., Fichtinger-Schepman, A. -M. J., Hill, B. I., Scanlon, K. J., Zeller, W. J., Chen, G., Gietema, J. A., de Vries, E. G. E, Sleijfer, D.Th, Willemse, P. H. B., Guchelaar, H. J., Uges, D. R. A., Aulenbacher, P., Voegeli, R., Mulder, N. H., Skrezek, C., Bertermann, H., Eichholtz-Wirth, H., Born, R., Bier, H., Koch, M., Bernhardt, G., Hählen, K., Reile, H., van Zantwijk, C. H., Wering, E. R. van, Görögh, T., Lippert, B., Werner, J. A., Eickbohm, J. E., Mickiseh, G. H., Gottesman, M. M., Pastan, I., Hofmann, J., Wolf, A., Spitaler, M., Bock, G., Grunicke, H., Ponstingl, H., Roth, I., Granzow, C., Dörner, C., Erttmann, R., Looft, G., Ossenkoppele, G. J., Scheffer, G. L., Atassi, G., Pierre, A., Kraus, L., Leonce, S., Regnier, G., Dhainaut, A., Ponstingl H., Stöhr M., Rohlff, C., Glazer, R. I., Cho-Chung, Y. S., Höllt, V., Kouba, M., Vogt, G., Allmeier, H., Nissen, N. I., Cros, S., Guilbaud, N., Dunn, T., Berlion, M., Atassi, G., Bizzari, J. P., Messing, A. M., Matuschek, A., Mutter, I., Kiwit, J. C. W., Bastian, L., Goretzki, P. E., Frilling, A., Simon, D., Röher, H. D., Reichle, A., Altmayr, F., Rastetter, J., Erbil, C., Jaques, G., Maasberg, M., Havemann, K., Häußermann, K., Heidebrecht, H. -J., Van de Vrie, W., Gheuens, E. E. O., Durante, N. M. C., De Bruijn, E. A., Marquet, R. L., Van Oosterom, A. T., Eggermont, A. M. M., Stow, M. W., Vickers, S. E., Warr, J. R., Roller, E., Eichelbaum, M., Klumpp, B., Krause, J., Schumacher, K., Hörner, S., Laßmann, A., Traugott, U., Schlick, E., Bürkle, D., Futscher BW, List AF, Dalton WS, Ladda, E., Bühl, K., Weimer, A., Eser, C., Hamprecht, K., Schalk, K. P., Jackisch, C., Brandt, B., Blum, M., Louwen, F., Schulz, K., Hanker, J. P., Rüther, U., Schmidt, A., Müller, H. A. G., Nunnensiek, C., Bader, H., Eisenberger, F., Jipp, P., Niethammer, B., Muller, C., Ling, V., Joncourt, F., Redmond, S., Stöhr, M., Buser, K., Fey, M., Tobler, A., Brunner, K., Gratwohl, A., Cerrry, T., Nuessler, V., Pelka-Fleischer, R., Nerl, C., Beckert, B., Wilmanns, W., Hegewisch-Becker, S., Fliegner, M., Zander, A., Hossfeld, D. K., Blanz, J., Mewes, K., Ehninger, G., Zeller, K. -P., Schuldes, H., Herrmann, G., Boeckmann, W., Schroeder, R., Jonas, D., Zurborn, K. -H., Bruhn, H. D., Uharek, L., Glass, B., Gassmann, W., Loeffler, H., Mueller-Ruohholtz, W., Gassmann W., Glass B., Uharek L., Loeffler H., Mueller-Ruchholtz W., Jaquet, K., Kreipe, H., Felgner, J., Radzun, H. J., Parwaresch, M. R., Kogan EA, Mazurenko NN, Sekamova SM, Wolf, H., Röhe, K., Wilkens, K., Clausen, M., Henze, E., van der Bosch, J., Rüller, S., Schlaak, M., Köhl, U., Schwabe, D., Rohrbach, E., Montag, E., Bauer, S., Cinatl, J., Cinatl, Jr, I., Mainke, M., Geiss, H., Kornhuber, B., Juhl, H., Stritzel, H., Kalhoff, H., Schniegel, W., Menke, T., Pröbsting, B., Schulze-Westhoff, P., Boos, J., Weidner, J., Wedemeyer, N., Wiedorn, K., Ueda, Y., Blasius, S., Wuisman, P., Böcker, W., Roessner, A., Dockhorn-Dworniczak, B., Ramm, D., Knebel, J., Sass, W., Aufderheide, M., and Seifert, J.

Published
1991
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62. Pan-cancer whole genome analyses of metastatic solid tumors

Author

Cuppen, E., primary, Priestley, P., additional, Baber, J., additional, Lolkema, M.P., additional, Steeghs, N., additional, de Bruijn, E., additional, Duyvesteyn, K., additional, Haidari, S., additional, van Hoeck, A., additional, Roepman, P., additional, Shale, C., additional, Voda, M., additional, Tjan-Heijnen, V.C.G., additional, Bloemendal, H., additional, van Herpen, C., additional, Labots, M., additional, Witteveen, P.O., additional, Smit, E.F., additional, Sleijfer, S., additional, and Voest, E.E., additional

Published
2019
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63. WGS implementation in standard cancer diagnostics for every cancer patient (WIDE)

Author

Roepman, P., primary, Bosch, L., additional, Samsom, K., additional, Schipper, L., additional, de Bruijn, E., additional, Hoes, L., additional, Riethorst, I., additional, Schoenmaker, L., additional, van der Kolk, L., additional, van Snellenberg, H., additional, Voest, E.E., additional, Cuppen, E., additional, Monkhorst, K., additional, and Meijer, G., additional

Published
2019
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67. Transfer of learning in Swedish technical vocational education : student experiences in the energy and industry programmes

Author

Kilbrink, Nina, Bjurulf, Veronica, Baartman, L. K. J., de Bruijn, E., Kilbrink, Nina, Bjurulf, Veronica, Baartman, L. K. J., and de Bruijn, E.

Abstract

One of the most important issues in vocational education is the interaction between learning at school and at different workplaces. Students need to transfer what they have learned in and between these different learning arenas. However, little agreement exists among researchers on how to conceptualise and empirically study transfer of learning. This article aims to enhance our understanding of this process in technical vocational education by adding a new perspective on transfer: the phenomenological lifeworld approach. Eleven interviews with students enrolled in the Energy and Industry programmes at a Swedish upper-secondary school were conducted. Three transfer themes emerged from the data: learning for new situations, variation and integration of theory and practice. The student perspective, based on the lifeworld approach shows that the different learning arenas – the school and workplaces – can complement each other. The learning arenas offer different opportunities for learning, and learning in both arenas is necessary in order to prepare for an unknown future, according to the students in this study.

Published
2018
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68. Elements affecting the development of professional learning communities in schools

Author

Schaap, H., De Bruijn, E. de, Schaap, H., and De Bruijn, E. de

Abstract

19 december 2017, Contains fulltext : 183568.pdf (Publisher’s version ) (Open Access), This article focuses on the development of professional learning communities (PLCs), which are communities within schools, composed of voluntary participating teachers facilitated by school principals with a specific task to accomplish as part of a larger innovation project. Four PLCs were observed during 3 years by using questionnaires and participatory research. The questionnaires revealed that PLCs differed in their group characteristics, collective learning processes and outcomes. Through participatory research, we explored seven elements affecting the development of PLCs, namely, task perceptions, group composition, tensions between roles, beliefs about alignment, reflective dialogues, socialisation and ownership. Beliefs about alignment, ownership and socialisation had sufficient impact on the development of the PLCs. A case study including two contrasting PLCs indicated interrelations between task perceptions and ownership by members and between ownership and socialisation activities. Regarding implications, this research suggests to explicitly create and facilitate reflective dialogues and ownership over time for PLCs to flourish.

Published
2018

69. Epistemic Communities in Urban Self-organization: A Systematic Review and Assessment

Author

de Bruijn, E. (Ewald), Gerrits, L.M. (Lasse), de Bruijn, E. (Ewald), and Gerrits, L.M. (Lasse)

Abstract

The application of the concept of self-organization has grown over time in the field of urban planning, but with various interpretations. This article presents a systematic review that aims to uncover whether different uses of self-organization are tied to epistemic communities. Through coding and bibliographical analysis, it became apparent that there are two epistemic communities that emphasize different conceptualizations of self-organization. They investigate different issues, use different methods, an

Published
2018
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70. Begeleiden van het leren op de werkplek; wat weten we al?

Author

Ceelen, Lieke, Khaled, Anne, Nieuwenhuis, A.F.M., de Bruijn, E., Welten Institute, RS-Research Program Welten Onderzoeksprogramma (WO), RS-Research Program CELSTEC/OTEC (CO), and RS-Research Program The Interaction between Implicit and Explicit Strategies for Behaviour (IIESB)

Published
2017

71. Hauwert

Author

Nobel, A., de Bruijn, E., and ASH (FGw)

Published
2017

72. Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping

Author

Vermeulen, C. Geeven, G. de Wit, E. Verstegen, M.J.A.M. Jansen, R.P.M. van Kranenburg, M. de Bruijn, E. Pulit, S.L. Kruisselbrink, E. Shahsavari, Z. Omrani, D. Zeinali, F. Najmabadi, H. Katsila, T. Vrettou, C. Patrinos, G.P. Traeger-Synodinos, J. Splinter, E. Beekman, J.M. Kheradmand Kia, S. te Meerman, G.J. Ploos van Amstel, H.K. de Laat, W.

Abstract

During pregnancy, cell-free DNA (cfDNA) in maternal blood encompasses a small percentage of cell-free fetal DNA (cffDNA), an easily accessible source for determination of fetal disease status in risk families through non-invasive procedures. In case of monogenic heritable disease, background maternal cfDNA prohibits direct observation of the maternally inherited allele. Non-invasive prenatal diagnostics (NIPD) of monogenic diseases therefore relies on parental haplotyping and statistical assessment of inherited alleles from cffDNA, techniques currently unavailable for routine clinical practice. Here, we present monogenic NIPD (MG-NIPD), which requires a blood sample from both parents, for targeted locus amplification (TLA)-based phasing of heterozygous variants selectively at a gene of interest. Capture probes-based targeted sequencing of cfDNA from the pregnant mother and a tailored statistical analysis enables predicting fetal gene inheritance. MG-NIPD was validated for 18 pregnancies, focusing on CFTR, CYP21A2, and HBB. In all cases we could predict the inherited alleles with >98% confidence, even at relatively early stages (8 weeks) of pregnancy. This prediction and the accuracy of parental haplotyping was confirmed by sequencing of fetal material obtained by parallel invasive procedures. MG-NIPD is a robust method that requires standard instrumentation and can be implemented in any clinic to provide families carrying a severe monogenic disease with a prenatal diagnostic test based on a simple blood draw. © 2017 The Authors

Published
2017

73. Revealing conceptual understanding of international business

Author

Ashley, S.M., Schaap, H., de Bruijn, E., Afd Educatie, Leerstoel Wubbels, Education and Learning: Development in Interaction, Afd Educatie, Leerstoel Wubbels, and Education and Learning: Development in Interaction

Subjects
Higher education, assessment, International business, Education, international business, 0502 economics and business, Pedagogy, ComputingMilieux_COMPUTERSANDEDUCATION, Sociology, Curriculum, Concept map, business.industry, essays, Knowledge level, 05 social sciences, Professional development, Cultivating Creativity in Education, 050301 education, Rubric, higher professional education, conceptual understanding, concept maps, Engineering ethics, Construct (philosophy), business, 0503 education, 050203 business & management
Abstract

Item does not contain fulltext This study aims to identify an adequate approach for revealing conceptual understanding in higher professional education. Revealing students’ conceptual understanding is an important step towards developing effective curricula, assessment and aligned teaching strategies to enhance conceptual understanding in higher education. Essays and concept maps were used to determine how students’ conceptual understanding of international business can be revealed adequately. To this end, 132 international business students in higher professional education were randomly assigned to four conditions to write essays and to construct concept maps about an international business research topic. The conditions were: essay alone, essay after concept map, concept map alone, and concept map after essay. An assessment rubric was used to assess the breadth and depth of students’ conceptual understanding. Results show essays are the most adequate approach for revealing conceptual understanding of international business. In particular, concept maps revealed fewer facts and less reasoning than essays. Essays written after concept maps were less effective than essays, possibly since students perceived these essays as redundant. Further research is suggested on how educators can foster conceptual understanding. 09 mei 2016

Published
2017

74. Beeldenstorm

Author

Nobel, A., de Bruijn, E., and ASH (FGw)

Published
2017

76. Dynamic head-neck stabilization in cervical dystonia

Author

Forbes, P.A. (Patrick A.), de Bruijn, E. (Edo), Nijmeijer, S.W.R. (Sebastiaan W.R.), Koelman, J.H.T.M. (Johannes ), Helm, F.C.T. (Frans C.) van der, Schouten, A.C. (A.), Tijssen, M.A. (Marina), Happee, R. (Riender), Forbes, P.A. (Patrick A.), de Bruijn, E. (Edo), Nijmeijer, S.W.R. (Sebastiaan W.R.), Koelman, J.H.T.M. (Johannes ), Helm, F.C.T. (Frans C.) van der, Schouten, A.C. (A.), Tijssen, M.A. (Marina), and Happee, R. (Riender)

Abstract

Background Effective sensorimotor integration is essential to modulate (adapt) neck stabilization strategies in response to varying tasks and disturbances. This study evaluates the hypothesis that relative to healthy controls cervical dystonia patients have an impaired ability to modulate afferent feedback for neck stabilization with changes in the frequency content of mechanical perturbations. Methods We applied anterior-posterior displacement perturbations (110 s) on the torso of seated subjects, while recording head-neck kinematics and muscular activity. We compared low bandwidth (0.2–1.2 Hz) and high bandwidth (0.2–8 Hz) perturbations where our previous research showed a profound modulation of stabilization strategies in healthy subjects. Cervical dystonia patients and age matched controls performed two tasks: (1) maintain head forward posture and (2) allow dystonia to dictate head posture. Findings Patients and controls demonstrated similar kinematic and muscular responses. Patient modulation was similar to that of healthy controls (P > 0.05); neck stiffness and afferent feedback decreased with high bandwidth perturbations. During the head forward task patients had an increased neck stiffness relative to controls (P < 0.05), due to increased afferent feedback. Interpretation The unaffected modulation of head-neck stabilization (both kinematic and muscular) in patients with cervical dystonia does not support the hypothesis of impaired afferent feedback modulation for neck stabilization.

Published
2017
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77. Dynamic head-neck stabilization and modulation with perturbation bandwidth investigated using a multisegment neuromuscular model

Author

Happee, R. (Riender), de Bruijn, E. (Edo), Forbes, P.A. (Patrick A.), Helm, F.C.T. (Frans C.) van der, Happee, R. (Riender), de Bruijn, E. (Edo), Forbes, P.A. (Patrick A.), and Helm, F.C.T. (Frans C.) van der

Abstract

The human head-neck system requires continuous stabilization in the presence of gravity and trunk motion. We investigated contributions of the vestibulocollic reflex (VCR), the cervicocollic reflex (CCR), and neck muscle co-contraction to head-in-space and head-on-trunk stabilization, and investigated modulation of the stabilization strategy with the frequency content of trunk perturbations and the presence of visual feedback.We developed a multisegment cervical spine model where reflex gains (VCR and CCR) and neck muscle co-contraction were estimated by fitting the model to the response of young healthy subjects, seated and exposed to anterior-posterior trunk motion, with frequency content from 0.3 up to 1, 2, 4 and 8. Hz, with and without visual feedback.The VCR contributed to head-in-space stabilization with a strong reduction of head rotation (<8. Hz) and a moderate reduction of head translation (>1. Hz). The CCR contributed to head-on-trunk stabilization with a reduction of head rotation and head translation relative to the trunk (<2. Hz). The CCR also proved essential to stabilize the individual intervertebral joints and prevent neck buckling. Co-contraction was estimated to be of minor relevance. Control strategies employed during low bandwidth perturbations most effectively reduced head rotation and head relative displacement up to 3. Hz while control strategies employed during high bandwidth perturbations reduced head global translation between 1 and 4. Hz. This indicates a shift from minimizing head-on-trunk rotation and translation during low bandwidth perturbations to minimizing head-in-space translation during high bandwidth perturbations. Presence of visual feedback had limited effects suggesting increased usage of vestibular feedback.

Published
2017
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78. Revealing conceptual understanding of international business

Author

Afd Educatie, Leerstoel Wubbels, Education and Learning: Development in Interaction, Ashley, S.M., Schaap, H., de Bruijn, E., Afd Educatie, Leerstoel Wubbels, Education and Learning: Development in Interaction, Ashley, S.M., Schaap, H., and de Bruijn, E.

Published
2017

79. Dystonic neck muscles show a shift in relative autospectral power during isometric contractions

Author

de Bruijn, E. (author), Nijmeijer, SWR (author), Forbes, P.A. (author), Koelman, JHTM (author), van der Helm, F.C.T. (author), Tijssen, MAJ (author), Happee, R. (author), de Bruijn, E. (author), Nijmeijer, SWR (author), Forbes, P.A. (author), Koelman, JHTM (author), van der Helm, F.C.T. (author), Tijssen, MAJ (author), and Happee, R. (author)

Abstract

Objective To identify effects of a deviant motor drive in the autospectral power of dystonic muscles during voluntary contraction in cervical dystonia patients. Methods Submaximal (20%) isometric head-neck tasks were performed with the head fixed, measuring surface EMG of the sternocleidomastoid, splenius capitis and semispinalis capitis in CD patients and controls. Autospectral power of muscle activity, and head forces was analyzed using cumulative distribution functions (CDF). A downward shift between the theta/low alpha-band (3-10 Hz) and the high alpha/beta-band (10-30 Hz) was detected using the CDF10, defined as the cumulative power from 3-10 Hz relative to power from 3-30 Hz. Results CDF10 was increased in dystonic muscles compared to controls and patient muscles unaffected by dystonia, due to a 3-10 Hz power increase and a 10-30 Hz decrease. CDF10 also increased in patient head forces. Conclusions Submaximal isometric contractions with the head fixed provided a well-defined test condition minimizing effects of reflexive feedback and tremor. We associate shifts in autospectral power with prokinetic sensorimotor control. Significance Analysis of autospectral power in isometric tasks with the head fixed is a promising approach in research and diagnostics of cervical dystonia., Biomechatronics & Human-Machine Control, Intelligent Vehicles

Published
2017
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80. Spectral EMG changes in Cervical Dystonia patients and the influence of botulinum toxin treatment

Author

Nijmeijer, S.W.R. (author), de Bruijn, E. (author), Verhagen, R. (author), Forbes, P.A. (author), Kamphuis, D.J. (author), Happee, R. (author), Tijssen, M.A.J. (author), Koelman, J.H.T.M. (author), Nijmeijer, S.W.R. (author), de Bruijn, E. (author), Verhagen, R. (author), Forbes, P.A. (author), Kamphuis, D.J. (author), Happee, R. (author), Tijssen, M.A.J. (author), and Koelman, J.H.T.M. (author)

Abstract

Botulinum toxin (BoNT) injections in the dystonic muscles is the preferred treatment for Cervical Dystonia (CD), but the proper identification of the dystonic muscles remains a challenge. Previous studies showed decreased 8–14 Hz autospectral power in the electromyography (EMG) of splenius muscles in CD patients. Cumulative distribution functions (CDF’s) of dystonic muscles showed increased CDF10 values, representing increased autospectral powers between 3 and 10 Hz, relative to power between 3 and 32 Hz. In this study, we evaluated both methods and investigated the effects of botulinum toxin. Intramuscular EMG recordings were obtained from the splenius, semispinalis, and sternocleidomastoid muscles during standardized isometric tasks in 4 BoNT-naïve CD patients, 12 BoNT-treated patients, and 8 healthy controls. BoNT-treated patients were measured 4–7 weeks after their last BoNT injections and again after 11–15 weeks. We found significantly decreased 8–14 Hz autospectral power in splenius muscles, but not in the semispinalis and sternocleidomastoid muscles of CD patients when compared to healthy controls. CDF10 analysis was superior in demonstrating subtle autospectral changes, and showed increased CDF10 values in all studied muscles of CD patients. These results did not change significantly after BoNT injections. Further studies are needed to investigate the origin of these autospectral changes in dystonia patients, and to assess their potential in muscle selection for BoNT treatment, Biomechatronics & Human-Machine Control, Intelligent Vehicles

Published
2017
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83. Defining conceptual understanding for teaching in international business

Author

Ashley, S.M., Schaap, H., de Bruijn, E., Afd Educatie, Education and Learning: Development in Interaction, Afd Educatie, and Education and Learning: Development in Interaction

Subjects
Knowledge management, Process management, out-of-the-box thinking, Business model, Education, Business relationship management, 0502 economics and business, Business architecture, Sociology, business.industry, Artifact-centric business process model, Business rule, 05 social sciences, Cultivating Creativity in Education, 050301 education, Business process modeling, higher professional education, teaching in international business, conceptual understanding, New business development, Business analysis, Business, Management and Accounting (miscellaneous), 050211 marketing, business, 0503 education
Abstract

Item does not contain fulltext The aim of this exploratory study is to develop a definition of conceptual understanding for teaching in international business. In international business, professionals face complex problems like what to produce, where to manufacture, which markets to target, and when to expand abroad. A clear definition of conceptual understanding needed to solve such problems would provide design input for international business education. In three cycles, two independent expert panels with backgrounds in academic research, international business education, and international business practice identified and validated key components of conceptual understanding in international business. Key components are the global and local contexts, general and specific business practices, and theoretical business concepts and mechanisms. Other key characteristics include factual knowledge, explanation, and out-of-the-box thinking. 14 oktober 2016

Published
2016

84. Abstracts of papers Pharmaceutical and biomedical analysis meeting

Author

Both-Miedema, R., Jansen, E. H. J. M., Claessens, H. A., Hendriks, P. J. M., Ackermans, M. T., Sparidans, R. W., Everaerts, F. M., de Groot, G., Koops, R., Wubs, K. L., Koops, R., de Jong, J., Cheung, S. F., Maessen, P. A., Pinedo, H. M., van der Vijgh, W. J. F., den Hartigh, J., Langebroek, R., Vermeij, P., Doom, L., van Leeuwen, F. X. R., Heeremans, C. E. M., van der Hoeven, R. A. M., Niessen, W. M. A., Tjaden, U. R., van der Greef, J., Hempenius, J., Staal, B., Jeuring, H. J., Mensink, C. K., Jonkman, J. H. G., Hindriks, H., Maris, F., Pasters, A., de Smet, M., Massart, D., Janssen, P. S. L., Hamelinck, R. L. A. E., Melgers, P. A. T. A., van Nispen, J. W., van Zeeland, M. J. M., van de Ven, M. H. J. M., Vink, J., Lambrechts, H., Pattyn, G., Van Oosterom, A. T., de Bruijn, E. A., Leeuwenkamp, O. R., Barto, R., Greuter, H., Lips, P., Netelenbos, J. C., Maris, F. A., Vervoort, R. J. M., Vrieling, M. B., Reinerink, E. J. M., van den Berg, R. H., Roets, E., Aerden, L., Hoogmartens, I., Rose, S. V., Crombeen, J. P., van Bueren, L. G. D. Lammerts, Rosing, H., Elferink, F., van de Vaart, F. J., Schoots, A. C., De Vries, P. H. J. M., Verheggen, T. P. E. M., Steijger, O. M., Hoksbergen, E., Baumann, R. A., Holthuis, J. J. M., Brinkman, U. A. Th., Takkenberg, B., van Ingen, H. E., Ackermans, M., Endert, E., Tjaden, UR, Reeuwijk, HJEM, van der Greef, J., Pattyn, G., van Oosterom, A. T., de Bruijn, E. A., van de Water, C., Haagsma, N., van den Ham, W. A., Piersma, A. H., van Ginkel, L. A., Stephany, R. W., Farla, J. C. M., van Rossum, H. J., van Gijn, R., Beijnen, J. H., de Clippeleir, J. J. M., Horenblas, S., Underberg, W. J. M., van Tellingen, O., Beilnen, J. H., van der Woude, H. R., Nooven, W. J., van Twillert, K., Zeijlmans, P. W. M., Olling, M., Derks, H. G. J. M., Naidong, Weng, Cachet, Th., Hoogmartens, J., Wieling, J., Coencgracht, P. M. J., Doornbos, D. A., and Windhorst, G.

Published
1989
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85. Abstracts of papers

Author

Uges, D. R. A., Bloemhof, H., Agoston, S., Ensing, K., de Zeeuw, R. A., Ymker, J., Greijdanus, B., Tjaden, U. R., de Bruijn, E. A., Hoeven, R. v. d., Stolk, L. M. L., Chandi-Bakridi, L. S., Filedt Kok, J. C., Schoemaker, T. J., Elferink, F., Paalman, A. C. A., Hoeven, R. T. M. vd, Vijgh, W. J. F. vd, Versluis, A., Necerhoed, A., Been, M. H., Dankert, J., Boom, F. A., Cox, H. L. M., Alblas, R. G., Vos, Th., van Beek, M. R. E., Stout-Zonneveld, A., Siddiqui, A. H., Cormane, R. H., Lohman, J. J. H. M., Hooymans, P. M., Verhey, M. T. J. M., Koten, M. L. P., Merkus, F. W. H. M., Overdiek, J. W. P. M., Vree, P. H., Zwart, P., Eijsink, B. J., Soeterboek, A. M., van Thiel, M. J. S., Westra, P., Vermeer, G. A., Claessens, H. A., van der Hoeven, R. T. M., Vermeij, P., Edelbroek, P. M., Ferrari, M. D., Buruma, O. J. S., Breimer, D. D., de Wolff, F. A., Cilissen, J., Hermens, W. A. J. J., Vree, T. B., Hekster, Y. A., Tijhuis, M. W., Nouws, J. F. M., Termond, E., de Bruijn, E. A., Leeflang, P. A., van Hijfte, M. M. C., van der Kleijn, E., Rosingh, E., Vree, T. B., Wuis, E. W., Zuidgeest, L. J. B., Arens, J., Kwa, H. Y., van der Lei, J., Hasman, A., Schuitemaker, M. G., Buurke, E. J., Doornbos, L., Ploeger, E. J., Neef, C., Lie-A-Huen, L., Rutten, J. J. M. H., Ydenberg, F. N., Delhaas, E. M., Brouwers, J. R. B. J., Boskma, R. J., Lip, H., Toll, P. J. M. M., Ligtenberg, E. A. A. M., Hoskam, P. F. J. M., Friesen, W. T., Mens, W., Wintermans, R., Vinks, A. A. T. M. M., Taks, J. M., Timmer, J. G., Vyth, A., de Jong, J. M. B. V., den Hartog Jager, W. A., Boerema, J. B. J., Benneker, Jose, van der Kleijn, Eppo, Vollaard, E. J., Clasener, H. A. L., Lameijer, W., van der Linden, C. Th. M., Wagenaar, J. P. M., Kraus, J. J. A. M., de Flines, E. W., Wolters, R. J., de Lange, R. G., Bel, J., Noome, C. F., Verweij, S. L., Nap, G., Petrus, J. A., Graatsma, B. H., Meilink, J. W., Brandenburg, H. C. R., de Nijs, S. J. M., and Konings, G. M. W.

Published
1984
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91. Isometric and Dynamic Control of Neck Muscles

Author

De Bruijn, E., Van der Helm, F.C.T., De Koning-Tijssen, M.A.J., and Happee, R.

Subjects
voluntary contraction, cervical dystonia, muscle synergy, isometric, neuromuscular model
Abstract

It is well established that the central nervous system (CNS) stabilizes the head using reflexive feedback and cocontraction. The major reflexive pathways in the neck are through muscle spindles generating the cervicocollic reflex (CCR) and through the vestibular organ generating the vestibulocollic reflex (VCR). The CNS modulates the contribution of the different pathways and the level of cocontraction to change the system dynamics in an effort to optimally withstand motion disturbances. Predetermined groups of muscles, called synergies, are used to generate stabilizing forces, but it is not clear how the CNS modulates the reflexive pathways and how the muscle groups are chosen. To understand the function of the different reflexive pathways and the responses of the different muscles musculoskeletal models are necessary. To date, a neck model with sufficient detail to simulate vertebral injury and reflexive control of individual muscles does not exist. There are a number of reasons why the behavior of the CNS in neck muscle control should be investigated. Cervical dystonia is a movement disorder characterized by involuntary activity of the neck muscles leading to debilitating abnormal postures and twisting movements. Current evidence points towards changes in the neuronal circuitry in the brain, but the underlying pathology remains for the most part unclear. The understanding of normal and aberrant control of muscles is an important key to finding a solution for this disorder. The current treatment involves injecting the dystonic muscles with botulinum toxin. Although this treatment is generally quite successful, it often remains difficult to distinguish dystonic muscles from healthy compensatory activation. Improvements in the protocols to select aberrant muscles in patients would improve the effectiveness of the treatment and could be an asset when treating more difficult cases. Two aims were set out in this thesis. The first was to establish how the CCR and VCR pathways activate individual muscles to ensure head and neck stabilization and how their gains modulate under different loading conditions. To this end a detailed neuromuscular model was developed containing reflexive neuromuscular feedback and cocontraction. The second aim was to understand the pathology behind cervical dystonia by quantifying aberrance of individual muscle activation in patients, and to develop a protocol to improved muscle selection for possible diagnostic use. In total, five studies were performed to achieve these goals. The first aim of this thesis was achieved by investigating neuromuscular control of healthy subjects using a dynamic experiment and a detailed neuromuscular model. First, we wanted to establish a relationship between the modulation of reflexes and the amplitude and bandwidth of a disturbance to the head and neck (Chapter 2). This was determined by perturbing seated subjects in an anteriorposterior direction with varying amplitudes and frequency content. We found a substantial attenuation of both vestibulocollic and cervicocollic reflexes as the frequency content of the perturbation increased, but only small changes with amplitude. The subjects performed these tasks with the eyes open and closed, and it was observed that with the eyes open subjects were able to further reduce the head motion in space. To investigate how and why the reflex pathways modulate with bandwidth a neuromuscular model was developed. A model including eight vertebrae and the skull and full joint motion was extended with a detailed set of 258 muscle segments. The spinal stiffness, muscle moment arms, instantaneous axes of rotation, and cervical strength were validated in its neutral position (Chapter 3). The importance of a mechanical equilibrium in the neck when estimating model strength was also addressed. The model was able to predict isometric muscle activation patterns of healthy subjects, and the study demonstrated that model strength will be overestimated particularly in flexion and axial rotation the equilibrium over all the neck joints is ignored. Neuromuscular control of the model was then implemented to enable dynamic simulations, which included the vestibulocollic and cervicocollic reflexes and cocontraction. Nonlinear sensory and muscle activation dynamics were implemented along with neural delays for the different feedback pathways. Muscle synergies defined in isometric conditions to generate directional forces under joint equilibrium were used to convert the reflexive vestibulocollic feedback of the semicircular canals and otoliths to individual muscle activations. A similar muscle synergy was used to generate cocontraction over a predefined set of muscles. The cervicocollic reflex was modelled such that each muscle element contained its stretch reflex (muscle length and velocity). The neuromuscular model was subsequently used to investigate the modulation changes with bandwidth observed in Chapter 2 by optimizing reflexive gains and cocontraction of the model to experimental subject data. A possible strategy involved in reflex modulation was also investigated by estimating muscle energy consumption (strategy to minimize effort) and head motion (strategy to stabilize the head). In this study, reflexive gains semicircular and muscle spindle gains were modulated in congruence with our hypothesis, showing gain reductions with increasing bandwidth. However, in contrast to the hypothesis cocontraction was also found to steadily increase with bandwidth. The primary strategy of the CNS appeared to be a suppression of resonant oscillations of the head between 1-3 Hz and, if necessary, between 6-8 Hz. When the perturbation bandwidth increased the reflexes and cocontraction were modulated to dampen the higher frequencies as they were being excited. To investigate aberrant activity of dystonic muscles a standardized protocol was developed by fixing the head of subjects in an isometric device. This ensured a similar position of the head and neck and allowed for controlled task instructions using head force measurements and visual feedback. Individual muscle electromyography (EMG) of 10 cervical dystonia patients and 10 healthy subjects were compared in different loading directions. To addresses a possible worsening of dystonic responses due to an increase in voluntary muscle contractions, activity was evaluated at different contraction levels. Increased levels of mean and minimum (cocontraction) EMG were found in clinically diagnosed dystonic muscles (Chapter 5) and the spectral content of these muscles was shifted (Chapter 6), likely indicating an altered control of the muscles by the central nervous system. The abnormal activity was found during submaximal contractions and in rest, but no differences were observed during maximal contractions. Also, no evidence was found of an exacerbation of dystonic activity related to an increase in muscle contraction when the head was fixed. These results seem to indicate that dystonic muscles are controlled during submaximal contractions much like healthy muscles are activated during maximal contractions. The identified aberrant activity in patient muscles was then evaluated as an identifier of dystonic muscles. The protocols were able to distinguish dystonic activity on a group level, but were not yet sufficiently accurate to be used as a diagnostic tool. Currently, a study is being performed with an improved setup and including patients not previously treated with botulinum toxin to further investigate the applicability of these methods for diagnostics. The contents of this thesis can be summarized with the following main conclusions: I. The central nervous system modulates reflex gains and cocontraction with the frequency content of perturbations with the goal to suppress resonant frequencies of the head while minimizing effort. II. Dystonia patients show increased mean and altered spectral muscle activity during submaximal contractions and rest, but not during maximal contractions. In addition, a higher level of muscle activation does not exacerbate dystonic activity. A neuromuscular model with full joint motion and reflexive control of individual muscles was developed, which is a valuable tool for future investigations into neuromuscular disorders and injury of the neck. The protocols for the identification of aberrant muscle activity in dystonia patients that were established in this thesis have the potential to be used for dystonic muscle selection in the future.

Published
2014
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92. Over grenzen: Pedagogisch-didactiche aspecten van het opleidingen voor beroepsuitoefening: Inleiding bij het het themanummer

Author

De Bruijn, E., Nieuwenhuis, A. F M, Leerstoel Brekelmans, and Education and Learning: Development in Interaction

Subjects
Education
Abstract

Het is duidelijk dat de relatie tussen opleidingen en beroepspraktijk voortdurend onder druk staat. Het mixed model vormgeven in de opleidingspraktijk van alledag betekent een wankel evenwicht en vraagt voortdurend professioneel balanceren van opleidingsteams, schoolmanagement en werkgevers, om de ambitie van een arbeidsmarktrelevante startkwalificatie voor iedereen hoog te blijven houden. In dit themanummer richten we ons op het pedagogisch-didactisch handelen van actoren binnen deze complexe opdracht. Hét onderscheidend kenmerk van beroepsonderwijs is dat leren en het begeleiden van dat leren plaats vindt op school én op de werkplek, en in variaties daarvan zoals simulaties binnen de school of leerafdelingen in het bedrijf. Het verbinden van die twee leerplekken vraagt om grensoverschrijdend handelen. Het opleiden tot startend beroepsbeoefenaar, en daarmee het ontwikkelen van een basis voor beroepsmatig handelen in termen van vakkennis, vakvaardigheid en beroepshouding, is niet mogelijk door deelnemers alleen in school of alleen in bedrijf hierop voor te bereiden; leren dient binnen én buiten de school plaats te vinden (Aarkrog, 2005; Poortman et al., 2012; Resnick, 1987; Schaap, Baartman & De Bruijn, 2012; Zitter & Hoeve, 2012). Een centraal kwaliteitsvraagstuk van beroepsonderwijs is vervolgens hoe de verbinding tussen de verschillende contexten wordt vormgegeven zodanig dat lerenden optimaal ondersteund worden het geleerde in die verschillende contexten te integreren. Uit onderzoek en verkenningen van dit kwaliteitsvraagstuk zijn interessante inzichten te formuleren die implicaties hebben voor het handelen van opleiders.

Published
2014

93. Identification of Srp9 as a febrile seizure suspectibility gene

Author

Hessel, EVS, de Wit, M, Woltering-Donselaar, IG, Karst, H, de Graaff, E, van Lith, HA, de Bruijn, E, de Sonnaville, S, Verbeek, NE, Lindhout, D, de Kovel, CGF, Koeleman, BPC, van Kempen, M, Brilstra, E, Cuppen, E, Loos, M, Spijker, S, Kan, AA, Baars, SE, van Rijen, PC, Gosselaar, PH, Groot Koerkamp, MJA, Holstege, FCP, Duijn, Cornelia, Vergeer, J, Moll, Henriette, Tauboll, E, Heuser, K, Ramakers, GJM, Pasterkamp, RJ, van Nieuwenhuizen, O, Hoogenraad, CC, Kas, MJH, De Graan, PNE, Epidemiology, and Pediatrics

Published
2014

96. Analysis of isometric cervical strength with a nonlinear musculoskeletal model with 48 degrees of freedom

Author

De Bruijn, E. (author), Van der Helm, F.C.T. (author), Happee, R. (author), De Bruijn, E. (author), Van der Helm, F.C.T. (author), and Happee, R. (author)

Abstract

Background: Musculoskeletal models served to analyze head–neck motion and injury during automotive impact. Although muscle activation is known to affect the kinematic response, a model with properly validated muscle contributions does not exist to date. The goal of this study was to enhance a musculoskeletal neck model and to validate passive properties, muscle moment arms, maximum isometric strength, and muscle activity. Methods: A dynamic nonlinear musculoskeletal model of the cervical spine with 48 degrees of freedom was extended with 129 bilateral muscle segments. The stiffness of the passive ligamentous spine was validated in flexion/extension, lateral bending, and axial rotation. Instantaneous joint centers of rotation were validated in flexion/extension, and muscle moment arms were validated in flexion/extension and lateral bending. A linearized static model was derived to predict isometric strength and muscle activation in horizontal head force and axial rotation tasks. Results: The ligamentous spine stiffness, instantaneous joint centers of rotation, muscle moment arms, cervical isometric strength, and muscle activation patterns were in general agreement with biomechanical data. Taking into account equilibrium of all neck joints, isometric strength was strongly reduced in flexion (46 %) and axial rotation (81 %) compared to a simplified solution only considering equilibrium around T1–C7, while effects were marginal in extension (3 %). Conclusions: For the first time, isometric strength and muscle activation patterns were accurately predicted using a neck model with full joint motion freedom. This study demonstrates that model strength will be overestimated particularly in flexion and axial rotation if only muscular moment generation at T1–C7 is taken into account and equilibrium in other neck joints is disregarded., Biomechanical Engineering, Mechanical, Maritime and Materials Engineering

Published
2015

98. Abstracts of papers clinical pharmacological meeting

Author

Brink, H., Derkx, F., Kolstee, H., Merkus, P., Smits, J., Man in 't Veld, A., Schslekamp, M., Postma, C. T., Hoefnagels, W. H. L., Thien, Th., van Bortel, L. M. A. B., Böhm, R. O. B., Mooy, J. M. V., Schiffers, P. M. H., Rahn, K. H., Donker, A. J. M., Frydman, A., van Leerdam, F. J. H., de Vries, P. M. J. H., Oe, P. L., Chang, P. C., van Veen, S., Vermey, P., van Brummelen, P., Molema, J., Lammers, J. -W. J., Folgering, H. Th. M., van Herwaarden, C. L. A., de Boer, A., Stiekema, J. C. J., Danhof, M., Boei jinga, J. K., Breimer, D. D., Blauw, G. J., van Zwieten, P. A., Doorenbos, C. J., Daha, M. R., Hermans, W. A. J. J., Schüsler-van Hees, M. T. I. W., Merkus, F. W. H. M., Oldenhof, H. G. J., de Jong, M., Steenhoek, A., Janknegt, R., Koelman, J. H., Nube, M. J., Franssen, C., Wollersheim, H., Veering, B. Th., Burm, A. G. L., van Kleef, J. W., Hennis, P. J., Spierdijk, Joh, Bovill, J. G., Breimer, L. T. M., de Bruijn, E. A., Schouten, J., Smits, P., van 't Laar, A., van Baak, M. A., Koene, F., Verstappen, F. T. J., van der Krogt, J. A., and van Brumelen, P.

Published
1987
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99. Abstracts of papers pharmacological meeting

Author

Beckorinqh, J. J., Korstanje, C., van Zwieten, P. A., Boddeke, H. W. G. M., Jonkman, F. A. M., Daemen, M., van Essen, H., Smits, J., Thljssen, H., de Bruijn, E. A., Driessen, O., Hermans, J., de Graeff, P. A., Kingma, J. H., van Gilst, W. H., Bel, K., de Langen, C. D. J., Wesselinq, H., Doods, H. N., Davidesko, D., Mathy, M. -J., Batink, H. D., de Jonge, A., Ellenbroek, B., Klockgether, T., Turskit, L., Schwarz, M., Cools, A., Franken, N. A. P., van Delft, J. L., van Langevelde, A., Dubbelman, T. M. A. R., Oosterhuis, J. A., Star, W. M., Marljnissen, J. P. A., Journée-de Korver, J. G., Pauwels, E. K. J., Haenen, G. R. M. M., Bast, A., de Vries, J., Vcrmeulen, N. P. E., Timmerman, H., Hugtenburg, J. G., Beckeringh, J. J., Janssen, B. J. A., Struyker-Boudier, H. A. J., Smits, J. F. N., Jonkman, P. A. M., Man, P. W., Knape, J. T. A., Lambalk, C. B., van Kessel, H., van Rees, G. P., Schoemaker, J., Lammers, J. H. C. M., Meelis, W., Kruk, M. R., van der Poel, A. M., Lippens, F. J. P., van Valkenburg, C. F. M., van der Krogt, J. A., Krick, E. W. C., Belfroid, R. D. M., Noach, E. L., Loesberg, C., Woutersen-v. Nijnanten, F. M. A., Nijkamp, F. P., Molenaar, P. C., Pen, B. S., Polak, R. L., Nievelstein, H. N. M. W., Tijssen, C. M., Smits, J. F. M., Plant jé, J. F., Stoof, J. C., Maikel Kaghoebar, Jan A., Huisman, M., van Ginneken, Cees A. M., Rahusen, F. D., Robillard, G. T., Wildevuur, Ch. R. N., Russel, F. C. M., van der Linden, P. E. M., Vermeulen, W. G., van Ginneken, C. A. M., Smits, R. P. J. H., Steinhusch, H. U. M., Mulder, A. H., ten Brink, E. M. J., van der Plas, J., van Giersbergen, P. L. M., Wlegant, V. M., de Jong, W., van Koppen, C. J., Hermanussen, M. W., Verrijp, C. N., Rodrigues de Miranda, J. F., Beld, A. J., Lammers, J. W. J., van Oosterhout, A. J. M., Vulto, Arnold G., Sharp, Trevor, Ungerstedt, Urban, Wolterink, G., and van Ree, J. M.

Published
1985
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100. Abstacts of papers

Author

van Hemert, K. H. F., Malherbe, R., Janssen, H. J. L., Debets, H. J. G., Weyland, J. W., Doornbos, D. A., de Galan, L., Kraak, J. C., Vermeulen, N. P. E., Burm, A. G., Graaff, M. v. d., Onkenhout, W., Westerink, B. H. C., ten Kate, N., Louwerens, J. W., Meijman, T. F., O'Hanlon, J. F., van Berkel, M. P., de Jong, B. J., de Bree, H., Koorn, E., Vincent, W. R., Bruins, A. P., Pras, N., Beijnen, J. H., Wiese, G., Voskuilen, M. C. H., Schepers, W. G. A. J., Underberg, W. J. M., Derks H. J. G. M., van Twillert K., Klaassen R., Zomer G., Feitsma, K. G., Bosman, J., Drenth, B. F. H., de Zeeuw, R. A., Hulshoff, A., Haan, H. B. P., Lingeman, H., van der Houwen, O. A. G. J., Teeuwsen, J., Jansen, E. H. J. M., van den Berg, R. H., Zomer, G., de Jong, G. J., Lammers, N., Spruit, F. J., Brinkman, U. A. Th., Frei, R. W., Jonkman, J. H. G., Schoenmaker, R., Hempenius, J., de Jong, J., Tjaden, U. R., Holtkamp, A. H., Kok, W. Th., Langenberg, J. P., Maris, F. A., Geerdink, R. R., Ploegmakers, H. H. J. L., Mertens, M. J. M., van Oort, W. J., Salemink, P. J. M., Kolkman-Roodbeen, J. C., Gribnau, T. C. J., Janssen, P. S. L., Post, P. C., van der Veen, A. J., Van Rooij, H. H., Akiera, A. F., Verrijk, R., Soudijn, W., Weijers-Everhard, J. P., de Bruijn, E. A., Hollander, J. M. R., Rosing, H., van de Vaart, F. J., and Indemans, A. W. M.

Published
1984
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