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58. List of Contributors

Author

Abbasi, Arjang, primary, Abdel-Moty, Elsayed, additional, Abdi, Salahadin, additional, Adin, David R., additional, Ahn, Sang-Ho, additional, Akuthota, Venu, additional, Ante, William A., additional, Antony, Alvin K., additional, Aprill, Charles N., additional, Are, Madhuri, additional, Auerbach, Joshua D., additional, Barolat, Giancarlo, additional, Bartholomeeusen, Katrien, additional, Bartoli, Lisa M., additional, Bermas, Bonnie Lee, additional, Bhagia, Sarjoo M., additional, Bhargava, Amit S., additional, Bhat, Atul L., additional, Birnbaum, Klaus, additional, Bogduk, Nikolai, additional, Bonaiuti, Donatella, additional, Bonaldi, Guiseppe, additional, Borg-Stein, Joanne, additional, Botwin, Kenneth P., additional, Brigham, Craig D., additional, Bronov, Oleg, additional, Brown, Lee Ann, additional, Brown, Mark D., additional, Bryce, Thomas N., additional, Burtony, Allen W., additional, Carrino, John A., additional, Chen, Bojun, additional, Chen, Yung Chuan, additional, Chin, Cynthia, additional, Chin, Kingsley R., additional, Chou, Larry H., additional, Chow, David W., additional, Cinotti, Gianluca, additional, Cohen, Steven P., additional, Cooke, Paul, additional, Cucuzzella, Anthony R., additional, Daniels, Richard J., additional, David, Kenny S., additional, Day, Gregory, additional, Day, Miles, additional, Delamarter, Rick B., additional, DePalma, Michael J., additional, Derby, Richard, additional, Dillingham, Timothy R., additional, Dolinskas, Carol A., additional, Drezner, Jonathan A., additional, Edrich, Thomas, additional, El-Abd, Omar, additional, Ellen, Mark I., additional, Elliott, Dawn M., additional, Everett, Clifford R., additional, Fayyazi, Amir H., additional, Feler, Claudio A., additional, Fernandez, Julius, additional, Ferrari, Robert, additional, Fischgrund, Jeffrey S., additional, Fishbain, David A., additional, Fitzgerald, Colleen M., additional, Floman, Yizhar, additional, Fox, Edward J., additional, Furman, Michael B., additional, Gallagher, Rollin M., additional, Garfin, Steven R., additional, Garvey, Timothy A., additional, Gatchel, Robert J., additional, Gerner, Peter, additional, Gerszten, Peter C., additional, Gilchrist, Russell V., additional, Gotlin, Robert S., additional, Grady, M. Sean, additional, Guyer, Richard D., additional, Haig, Andrew J., additional, Hanks, Stephen, additional, Hannibal, Matthew, additional, Harb, Mouchir, additional, Harney, Donal F., additional, Harrast, Mark A., additional, Hasan, Syed Anees, additional, Haspeslagh, Sara Ruth Sanne, additional, Heavner, James, additional, Hellinger, Johannes, additional, Hellinger, Stefan, additional, Helper, Steven, additional, Herkowitz, Harry N., additional, Hosalkar, Harish S., additional, Hsu, Kenneth, additional, Hubbard, Raymond D., additional, Huston, Christopher W., additional, Isaac, Victor W., additional, Isaac, Zacharia, additional, Kang, James D., additional, Kantha, Brinda S., additional, Kaplan, Frederick S., additional, Karppinen, Jaro, additional, Kawaguchi, Yoshiharu, additional, Hynes, Christina Kerger, additional, Kim, Byung-Jo, additional, Kim, Choll W., additional, Kim, Daniel H., additional, Kim, David H., additional, Knaub, Mark A., additional, Krabak, Brian J., additional, Krames, Elliot S., additional, Kristiansson, Per O.J., additional, Kouri, Jukka-Pekka, additional, Lackman, Richard D., additional, Lagattuta, Francis P., additional, Lane, Joseph M., additional, Le, Hoang N., additional, Lee, Kathryn E., additional, Lee, Sang-Heon, additional, Lenrow, David A., additional, Lento, Paul H., additional, Lieberman, Isador H., additional, Lin, Julie T., additional, Lipetz, Jason S., additional, Liss, Donald, additional, Liss, Howard, additional, Lobel, Steven M., additional, López-Acevedo, Carmen E, additional, Lord, Susan M., additional, Lu, William W., additional, Luk, Keith D.K., additional, Lutz, Gregory E., additional, Maigne, Jean-Yves, additional, Malanga, Gerard A., additional, Marley, Julie, additional, Materson, Richard, additional, Mattern, Christopher J., additional, Mayer, Eric A.K., additional, Mayer, Tom G., additional, McCabe, Frank, additional, McLaughlin, Colleen, additional, McPhee, Ian Bruce, additional, Mehta, Samir, additional, Melfi, Renée S., additional, Metkus, Thomas, additional, Michaels, Mathew, additional, Micheo, William F., additional, Minkoff, Evan R., additional, Moley, Peter J., additional, Monticone, Marco, additional, Moonis, Gul, additional, Moore, Michael Ray, additional, Moskowitz, Michael H., additional, Mostoufi, S. Ali, additional, Nadler, Scott F., additional, Negrini, Stefano, additional, Niederwanger, Markus, additional, O'Neill, Conor W., additional, Ohnmeiss, Donna D., additional, Ostelo, Raymond W.J.G., additional, Ostrowski, Jeffrey, additional, Park, Ashley Lewis, additional, Parmar, Vikram, additional, Patel, Rajeev K., additional, Perry, Andrew, additional, Phillips, Frank M., additional, Pignolo, Robert J., additional, Plastaras, Christopher T., additional, Postacchini, Franco, additional, Postacchini, Roberto, additional, Pradhan, Ben B., additional, Prager, Joshua P., additional, Prather, Heidi, additional, Prawak, Adriana S., additional, Press, Joel M., additional, Qiu, G.X., additional, Racz, Gabor B., additional, Ragnarsson, Kristjan T., additional, Rao, Raj D., additional, Reeves, Ryan S., additional, Rigolosi, Luke, additional, Rosomoff, Hubert L., additional, Rosomoff, Renee Steele, additional, Rothman, Sarah M., additional, Russell, Anthony S., additional, Rydevik, Bjorn, additional, Sakalkale, Durgadas, additional, Savarese, Robert, additional, Sawchuk, Terry C., additional, Schofferman, Jerome, additional, Schuster, James, additional, Schwartz, Eric D., additional, Shah, Rinoo Vasant, additional, Sheth, Parag, additional, Simeone, Frederick A., additional, Simotas, Alexander C., additional, Singh, Gurkirpal, additional, Singh, Ramnik, additional, Skaggs, Clayton D, additional, Slezak, Jan, additional, Slipman, Curtis W., additional, Smeal, Wesley L., additional, Solomon, Jennifer L., additional, Sommer, Hillel M., additional, Sorosky, Brad, additional, Southern, Daniel, additional, Sowa, Gwendolyn A., additional, Stojanovic, Milan P., additional, Sullivan, William J., additional, Talu, Gul Koknel, additional, Tarquinio, Andrea, additional, Tasca, Philip, additional, Thomas, Santhosh A., additional, Thongtrangan, Issada, additional, Tirado, Carlos F., additional, Tobey, John E., additional, Togawa, Daisuke, additional, Torbert, Jesse T., additional, Trevisan, Carlo, additional, Triano, John J., additional, Tyburski, Mark D., additional, Uddin, Mohammad N., additional, Vaccaro, Alexander, additional, Vad, Vijay B., additional, Wiele, Christophe Van de, additional, van Kleef, Maarten, additional, Van Zundert, Jan, additional, Vlassakov, Kamen, additional, Weigele, John B., additional, Welch, William C., additional, Wen, C.Y., additional, Windsor, Robert E., additional, Winklestein, Beth A., additional, Won, Douglas S., additional, Wood, Kirkham, additional, Yerramalli, Chandra S, additional, Yeung, Anthony T., additional, Yeung, Christopher Alan, additional, Yin, Way, additional, Zaman, Faisel M., additional, and Zucherman, James F., additional

Published
2008
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62. Epidurography

Author

Meyer, Jeffrey P., primary, Day, Miles R., additional, and Racz, Gabor B., additional

Published
2007
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66. Contributors

Author

Abdelhalim, Ahmed N., primary, Abdi, Salahadin, additional, Abrams, Bernard M., additional, Akhouri, Vimal, additional, Alberico, Ronald A., additional, Aldrete, J. Antonio, additional, Andrasik, Frank, additional, Atluri, Sairam, additional, Askay, Shelley Wiechman, additional, Bajwa, Zahid H., additional, Bankston, David P., additional, Baron, Ralf, additional, Barry, Jonathan, additional, Binder, Andreas, additional, Bloodworth, Donna, additional, Bogduk, Nikolai, additional, Borenstein, David, additional, Boswell, Mark V., additional, Bove, Geoffrey, additional, Braiteh, Fadi, additional, Brown, David L., additional, Bruera, Eduardo, additional, Burton, Allen W., additional, Cady, Roger K., additional, Candido, Kenneth D., additional, Carrino, John A., additional, Chiang, Joseph S., additional, Childers, Martin K., additional, Chou, Eric T., additional, Conaghan, Philip G., additional, Correll, Darin J., additional, Cozad, Scott C., additional, Craig, Edward V., additional, Creamer, Paul, additional, Day, Miles R., additional, DeAngelo, Debra A., additional, Diamond, Seymour, additional, Dieppe, Paul, additional, Donohoe, Charles D., additional, Evans, James, additional, Fam, Adel G., additional, Farmer, Kathleen U., additional, Freitag, Frederick G., additional, Garcia, M. Kay, additional, Goodman, Scott, additional, Gordin, Vitaly, additional, Grabois, Martin, additional, Gracey, Douglas R., additional, Greenfield, Mark A., additional, Gupta, Rakesh, additional, Hainline, Brian, additional, Hall, Howard R., additional, Hassenbusch, Samuel J., additional, Hazleman, Brian L., additional, Heavner, James E., additional, Henshaw, D. Ross, additional, Hou, David Dai-Fu, additional, Jain, Subhash, additional, Janata, Jeffrey W., additional, Katz, Joel, additional, Kidd, Bruce L., additional, Kline, Matthew T., additional, Kopacz, Dan J., additional, Koyyalagunta, Dhanalakshmi, additional, Kropp, Lawrence, additional, Landers, Milton H., additional, Lema, Mark J., additional, Levin, Jennifer B., additional, Lovrincevic, Mirjana, additional, Luo, Z. David, additional, Manchikanti, Laxmaiah, additional, Markert, Chad, additional, McGuirk, Brian, additional, Melzack, Ronald, additional, Mendez, Jose L., additional, Meyer, Jeffrey P., additional, Munz, Michael, additional, Myers, David P., additional, Nielsen, Joel A., additional, Nissan, George R., additional, Nguyen, Son Truong, additional, O'Leary, Kathleen A., additional, Overbaugh, Robert H., additional, Pappas, John L., additional, Parris, Winston C.V., additional, Patel, Divya, additional, Patt, Richard B., additional, Patterson, David R., additional, Quave, Brett T., additional, Racz, Gabor B., additional, Raj, P. Prithvi, additional, Ramamurthy, Somayaji, additional, Reeves, K. Dean, additional, Reynolds, Lowell W., additional, Rime, Carla, additional, Rosen, Steven, additional, Rupert, Matthew P., additional, Saberski, Lloyd R., additional, Schattschneider, Jörn, additional, Schrattenholzer, Thomas F., additional, Schreiber, Curtis P., additional, Schultz, David M., additional, Sharar, Sam R., additional, Sills, Shawn M., additional, Sial, Khuram A., additional, Simon, Steven, additional, Simopoulos, Thomas T., additional, Singh, Vijay, additional, Smith-Martin, Kimberley, additional, Solanki, Daneshvari R., additional, Soto-Quijano, David A., additional, Stanton-Hicks, Michael D., additional, Stiles, M. Alan, additional, Supernaw, Robert B., additional, Swenson, Rand S., additional, Thompson, Gale E., additional, Treffer, Kavin D., additional, Trout, Robert, additional, Urban, George, additional, Vladutu, Luminita, additional, Waldman, Howard J., additional, Waldman, Katherine A., additional, Waldman, Steven D., additional, Warfield, Carol A., additional, Whitworth, Michael L., additional, Winnie, Alon P., additional, Wong, Gilbert Y., additional, Yaksh, Tony L., additional, Yarussi, Anthony T., additional, Yin, Way, additional, and Yoon, Michael S., additional

Published
2007
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80. Ramamurthy's Decision Making in Pain Management: An Algorithmic Approach

Author

Nagpal, Ameet, Day, Miles, Eckmann, Maxim S, Boies, Brian T, Driver, Larry C, Nagpal, Ameet, Day, Miles, Eckmann, Maxim S, Boies, Brian T, and Driver, Larry C

Subjects
Anesthesia--Decision making
Abstract

The book “Ramamurthy's Decision Making in Pain Management: An Algorithmic Approach” is not meant to replace in-depth, highly referenced textbooks in pain medicine. It may, nevertheless, be a valuable supplement, providing pain clinicians with a logical, concise, stepwise approach to the identification, diagnosis, and management of various acute or chronic pain conditions or syndromes. There have been great advances in the concepts, approaches, treatment options, and technology in pain medicine, which necessitate significant revision in order to make the book more relevant to the present-day practitioner. This book comprises 15 sections, which includes 145 chapters, which are thoroughly revised and updated. The first and second sections discuss the evaluation of pain and acute pain. The third and fourth sections describe the chronic pain syndromes and cancer pain. The fifth and sixth sections provide details about the head and neck pain and thoracic pain. The seventh and eighth sections cover the low back pain and upper extremity pain. The ninth and tenth sections deal with the lower extremity pain and pediatric pain. The eleventh and twelfth sections focus on pharmacology and opioid pharmacology. The thirteenth and fourteenth sections discuss the noninterventional therapeutic modalities and interventional therapeutic modalities. The final section gives an overview on other topics, which includes pain management ethics, imaging use during interventional procedures, radiographic contrast media, and controversial therapies.

Published
2018

82. Bipolar Pulsed Radiofrequency for Trigeminal Neuralgia: A Report of Two Cases.

Author

Silva, Victor, Day, Miles, and Santiago, Margarita

Subjects
*RADIO frequency therapy, *TREATMENT duration, *TREATMENT effectiveness, *BIOELECTRIC impedance, *QUALITY of life, *TRIGEMINAL neuralgia
Abstract

Background: Trigeminal neuralgia (TN) is the most common cause of facial pain, leading to significant disability and impacting a patient's quality of life. Percutaneous procedures like continuous radiofrequency, pulsed radiofrequency (PRF), and combined continuous and pulsed radiofrequency have been studied in past years comparing different voltages in order to find more effective therapies with fewer complications (eg, numbness and masseter muscle weakness). With regard to young patients, there is still insufficient evidence on the most appropriate procedure in this patient population. PRF does not cause thermal damage. The mechanism of action involves delivering an electrical field to targeted nerves or tissues, modulating pain. We propose that bipolar pulsed radiofrequency (2 parallel cannulas) in the trigeminal ganglion produce a denser and larger field resulting in more effective controlled pain. Case Presentation: We present 2 cases of 40‐ and 48‐year‐old men with severe V2 to V3 TN who underwent bipolar PRF. We performed bipolar PRF on the trigeminal ganglion through the foramen ovale using two 22‐gauge 100‐mm cannulas with 10‐mm active tips. Parameters used were voltage of 85 V, pulse width of 20 milliseconds, and total duration time of 6 minutes. Both patients reported complete relief of pain after the procedure, and at 2‐year follow‐up they were pain free and experienced a better quality of life. No complications were reported. Conclusion: Bipolar PRF could be a non‐neurodestructive option for young people with TN and deserves further investigation as a treatment option. [ABSTRACT FROM AUTHOR]

Published
2021
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87. 2015 Young Investigator Award Winner: Cervical Nerve Root Displacement and Strain During Upper Limb Neural Tension Testing: Part 2: Role of Foraminal Ligaments in the Cervical Spine.

Author

Lohman, Chelsea CM, Gilbert, Kerry, Sobczak, Stéphane, Brismée, Jean-Michel, James, C Roger, Day, Miles, Smith, Michael P, Taylor, LesLee, Dugailly, Pierre-Michel, Pendergrass, Timothy, Sizer, Phillip J, Lohman, Chelsea CM, Gilbert, Kerry, Sobczak, Stéphane, Brismée, Jean-Michel, James, C Roger, Day, Miles, Smith, Michael P, Taylor, LesLee, Dugailly, Pierre-Michel, Pendergrass, Timothy, and Sizer, Phillip J

Abstract

A cross-sectional cadaveric examination of the mechanical effect of foraminal ligaments on cervical nerve root displacement and strain., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015

88. 2015 Young Investigator Award Winner: Cervical Nerve Root Displacement and Strain During Upper Limb Neural Tension Testing: Part 1: A Minimally Invasive Assessment in Unembalmed Cadavers.

Author

Lohman, Chelsea CM, Gilbert, Kerry, Sobczak, Stéphane, Brismée, Jean-Michel, James, C Roger, Day, Miles, Smith, Michael P, Taylor, LesLee, Dugailly, Pierre-Michel, Pendergrass, Timothy, Sizer, Phillip J, Lohman, Chelsea CM, Gilbert, Kerry, Sobczak, Stéphane, Brismée, Jean-Michel, James, C Roger, Day, Miles, Smith, Michael P, Taylor, LesLee, Dugailly, Pierre-Michel, Pendergrass, Timothy, and Sizer, Phillip J

Abstract

A cross-sectional cadaveric examination of displacement and strain measured at the level of the cervical nerve roots during upper limb neural tension testing (ULNTT) with median nerve bias., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015

89. 2015 Young Investigator Award Winner

Author

Lohman, Chelsea M., primary, Gilbert, Kerry K., additional, Sobczak, Stéphane, additional, Brismée, Jean-Michel, additional, James, C. Roger, additional, Day, Miles, additional, Smith, Michael P., additional, Taylor, LesLee, additional, Dugailly, Pierre-Michel, additional, Pendergrass, Timothy, additional, and Sizer, Phillip J., additional

Published
2015
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90. Sphenopalatine ganglion pulsed radiofrequency treatment in 30 patients suffering from chronic face and head pain

Author

Day Miles, Erin Z. Bayer, James E. Heavner, and Gabor B. Racz

Subjects
medicine.medical_specialty, Dysesthesia, Pulsed radiofrequency, business.industry, Pharynx, medicine.disease, Ganglion, Surgery, law.invention, Anesthesiology and Pain Medicine, Hematoma, medicine.anatomical_structure, Randomized controlled trial, law, Anesthesia, Maxilla, medicine, medicine.symptom, business, Adverse effect
Abstract

This study evaluated the efficacy of sphenopalatine ganglion pulsed radiofrequency (SPG-PRF) treatment in patients suffering from chronic head and face pain. Thirty patients were observed from 4 to 52 months after PRF treatment. The primary efficacy measures were the reduction in oral medication use, including opioids, time-to-next-treatment modality for presenting symptoms, duration of pain relief, and the presence of residual symptoms. Secondary objectives included the evaluation of adverse effects and complications. All data were derived from patient charts, phone conversations, and clinical follow-up visits. Fourteen percent of respondents reported no pain relief, 21% had complete pain relief, and 65% of the patients reported mild to moderate pain relief from SPG-PRF treatment. Sixty-five percent of the respondents reported mild to moderate reduction in oral opioids. None of the patients developed significant infection, bleeding, hematoma formation, dysesthesia, or numbness of palate, maxilla, or posterior pharynx. A large-scale study of SPG-PRF for the treatment of face and head pain has not been previously reported. Our results suggest that a prospective, randomized, controlled trial study to confirm efficacy and safety of this novel treatment for chronic head and face pain is justified.

Published
2006

96. COLABORADORES

Author

Aldrete, J. Antonio, Fernández, Mercedes Alonso, de Oliveira, Charles Amaral, de Vasconcelos, Rodrigo Antunes, Araujo, Marco, Plancarte, Christopher Armas, Arteaga, Ricardo Eduardo, Asenjo, Juan Francisco, Assis, Fabrício Dias, Alarcón, Wilson Astudillo, Beltrutti, Diego, da Costa, Sílvia Maria Bordignon, Bosscher, Hemmo A., Briola, Osvaldo, Buchholz, Bruno, Carvalho, Ana Paula Cachola, Campo, Gema, Capello, Marianela Soledad, de Tejerina, Ana M.ª Casas Fernández, Castro, Luis, Cattaneo, Alfredo Néstor, Cervero, Fernando, Gómez, Faride Chejne, Cosman, Eric, Jr., Daftarian, Ali, Das, Gautam, David, Marc, Day, Miles, de Andrés Ares, Javier, de la Cruz Pineda, Juan, de Lima Freitas, Gabriela, DeJongste, Mike J., Siqueira, José Luiz Dias, Drummond, Eleanor S., Drummond, Peter D., Durán, Pilar, Enright, Angela, Erdine, Serdar, Dueñas, Elena Fernández, Finch, Phillip, Finkel, Diana, Gill, Jatinder S., del Rocío Guillén Núñez, María, Cubillo, Nora C. Godínez, Rosas, Jorge Guajardo, Heavner, James E., Holmann, Juan Ignacio, Illner, Hana, Irwin, David, Mateos, Esperanza Jiménez, Andrade, Juan Miguel Jiménez, Justiz, Rafael, Krashin, Daniel, Ramón, Ana Lahoz, Laporta, Yolanda, Lee, Sang Chul, Linetsky, Felix S., López, José Antonio López, Martínez-Jauand, Mercedes, Mavrocordatos, Phillipe, McGowan, Patrick R., Mehta, Palak, Meli, Marcello, Mendinueta, Carmen, Mishra, Rahul, Montoya, Pedro, Morán, María Pilar, Murinova, Natalia, Noe, Carl E., Ortiz, Frutos Enrique, Beninati, Miguel Ángel Paladino, Patel, Nileshkumar, González, Raquel Pérez, Sánchez, Ricardo Plancarte, Racz, Gabor B., Raffaini, Alexandra, Raj, Prithvi, Bermejo, Alfredo Ramírez, Reinoso-Barbero, Francisco, Pérez, Emilio Rodríguez, López, Ricardo Ruiz, Carretero, Pascual Sanabria, Sanoja, Raul, MD, Sanford M. Silverman, Skouvaklis, Danielle, Sluijter, Menno, Smith, Jeffrey P., Stojanovic, Milan P., Taylor, Victor, Teixeira, Alexandre, Morera, Luis Miguel Torres, Trescot, Andrea M., Martín-Arroyo, José Manuel Trinidad, Vallejo, Ricardo, Vanetti, Thais, Moyano, Marta Vázquez, Wüst, Graciela C., and Yazdani, Shiraz

Published
2015
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98. The development of a technique for radiofrequency lesioning of splanchnic nerves.

Author

Raj, P., Thomas, Jared, Heavner, James, Racz, Gabor, Lou, Leland, Day, Miles, and Shaw, Benny

Abstract

This article describes the development of a technique for radiofrequency lesioning of the splanchnic nerves. It features point neurolysis and improvement in safety from previously described techniques with the use of a curved, blunt needle. After extensive anatomic studies, the site of entry has been identified 4 cm lateral to the spinous process at the costovertebral angle of either the T11 or T12 vertebral body, and the placement of the needle tip at the junction of posterior two thirds to the anterior one third of the vertebral body. The use of a sharp, straight needle has been discouraged to prevent pneumothorax, and bowel, kidney, or nerve root injury. The radiofrequency lesion permits a point neurolysis, thus decreasing the rate of complications. Our experience of 22 patients treated with this technique has been complication-free, and the outcome was effective for all 10 patients with cancer. In the nonmalignancy group, some patients needed a second neurolysis (radiofrequency) procedure 4 months apart. There were also no secondary complications in these patients. We expect multicenter data accumulation in the coming years, which will determine the true efficacy of the radiofrequency of splanchnic nerves. [ABSTRACT FROM AUTHOR]

Published
1999
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99. Hyaluronidase: a review of approved formulations, indications and off-label use in chronic pain management

Author

Dunn, Amber L, Heavner, James E, Racz, Gabor, and Day, Miles

Abstract

Importance of the field:Hyaluronidase for injection is an adjuvant that increases the absorption and dispersion of other injected drugs or fluids (hypodermoclysis); and improves absorption of radiopaque agents in subcutaneous urography. Ovine hyaluronidase is approved for the treatment of vitreous hemorrhages.Areas covered in this review:We review approved indications for injectable hyaluronidase and off-label uses as well as safety, efficacy and dosing information. We compare formulations made using animal tissue extracts versus the novel human recombinant type. Emphasis is on the human recombinant form and off-label uses in patients with chronic pain.What the reader will gain:Hyaluronidase reduces the obstacle that the interstitial matrix presents to fluid and drug transfer. It is a mucolytic enzyme derived from mammalian tissue or synthesized in vitroin pure form (rHuPH20) using recombinant technology. Hyaluronidase is used off-label in chronic pain management to facilitate removal of epidural adhesions with mechanical and/or hydrostatic forces and to treat edema.Take home message:The recently introduced rHuPH20 formulation obviates any risk of allergic reaction or prion-related illnesses. Reduction of edema by hyaluronidase and facilitation of epidural adhesioloysis may be beneficial in treating certain chronic painful conditions.

Published
2010
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100. IN RESPONSE TO DRS. PLANCARTE, GUAJARDO, AND LEE.

Author

Day, Miles

Subjects
*LETTERS to the editor, *GANGLIONIC blocking agents
Abstract

A response by Miles Day to a letter to the editor about his article on the description of the blockade of the ganglion of Walther published in the previous issue.

Published
2008
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