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54. Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis

Author

Kottyan, Leah C., Maddox, Avery, Braxton, Julian R., Stucke, Emily M., Mukkada, Vince, Putnam, Philip E., Abonia, J. Pablo, Chehade, Mirna, Wood, Robert A., Pesek, Robbie D., Vickery, Brian P., Furuta, Glenn T., Dawson, Peter, Sampson, Hugh A., Martin, Lisa J., Kelly, Jennifer A., Kimberly, Robert P., Sivils, Kathy, Gaffney, Patrick M., Kaufman, Kenneth, Harley, John B., and Rothenberg, Marc E.

Published
2019
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56. Experimental and theoretical studies of iodonium salts

Author

Dawson, Peter K. D.

Subjects
547.02
Abstract

Hypervalent iodine compounds -1(111) and I(V) - are well documented and have been known to exist for over 100 years. The compounds have many synthetic applications, for instance acting as mild oxidising agents. Of the iodine (HI) class, alkenylaryliodonium salts have received much less attention than other species. As a result the preparation and uses of these compounds are less well understood. Advancing our knowledge in the chemistry of iodonium salts, specifically alkenylaryliodonium salts, is important in utilising the unique chemical and structural properties of such compounds.

Published
2009

58. Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV 144 HIV Vaccine Efficacy Trial

Author

RV305 Study Team, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Excler, Jean-Louis, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Premsri, Nakorn, Kunasol, Prayura, Karasavvas, Nicos, Schuetz, Alexandra, Ngauy, Viseth, Sinangil, Faruk, Dawson, Peter, deCamp, Allan C., Phogat, Sanjay, Garunathan, Sanjay, Tartaglia, James, DiazGranados, Carlos, Ratto-Kim, Silvia, Pegu, Poonam, Eller, Michael, Karnasuta, Chitraporn, Montefiori, David C., Sawant, Sheetal, Vandergrift, Nathan, Wills, Saintedym, Tomaras, Georgia D., Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Vasan, Sandhya, and O'Connell, Robert J.

Published
2017

59. Calamus caesius (Rattan) wood: Chemical constituents, biological activities’ relative medicinal properties from Thai medicinal scriptures, and in silico antioxidant activity

Author

Net-anong, Soiphet, primary, Prommee, Nuntika, additional, Dechayont, Bhanuz, additional, Prajuabjinda, Onmanee, additional, Yangthaworn, Kitiya, additional, Chunthorng-Orn, Jitpisute, additional, Phuaklee, Pathompong, additional, Dawson, Peter W.J., additional, and Juckmeta, Thana, additional

Published
2023
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65. Measurement and evaluation of managerial efficiency in English league football : a stochastic frontier analysis

Author

Dawson, Peter Michael and Dobson, Stephen

Subjects
658, Economics, Management, Sports, Recreation
Abstract

[From the introduction]: The thesis is organised as follows. In Chapters 1 and 2 we present a review of the existing literature. Chapter 1 analyses the role of incentives and human capital attributes as mechanisms for determining performance. Much of the previous literature analyses manager performance using wage equations. What is unique in our approach is that we are able to generate a direct measure of managerial performance. The background to the methodology used is provided in Chapter 2. Here we explore the growing literature on production frontier analysis. We are particularly interested in the available estimation procedures and how previous sports studies have utilised this framework in estimating efficiency. A discussion of the football industry is the focus of Chapter 3, while in Chapter 4 we develop the theoretical model of manager performance. Data and methodological issues are addressed in Chapter 5. Chapters 6 and 7 contain the empirical results. In Chapter 6 we generate managerial efficiency scores and consider how alternative input and output measures and alternative estimation procedures affect these scores. Using the preferred model from Chapter 6, Chapter 7 provides a detailed account of how human capital factors and incentives shape efficiency and some preliminary results as to whether the manager actually matters. Finally, Chapter 8 provides some conclusions and recommendations in the light of the empirical results.

Published
2000

73. A hierarchical approach to the management of construction project risk

Author

Dawson, Peter James

Subjects
624, HD Industries. Land use. Labor
Abstract

This thesis considers work undertaken in the area of the management of construction project risk. The construction industry in Britain is undergoing a radical change; new markets are opening up as traditional ones close, and the nature of contracts are changing with the increasing popularity of design-build and the development of the Government's Private Finance Initiative. These changes have left many construction companies moving into markets in which they have little experience or entering into contracts which allocate risks to them which have previously been held by others. Since the traditional method of managing risks was by using the experience and judgment of managers, this has left many companies in a dangerous position, selecting projects with little knowledge of the risks the company is already exposed to, the extent to which the company wants the project, or the change that project will make to the risk profile. An investigation into the formal approach to risk management, developed over the last few decades as a way of progressing from the purely experience based approach, concludes that although several of the techniques offer an improvement, the overall approach does not consider the company. Projects are treated as independent entities rather than temporary parts of the company's ongoing activities. A system is produced which builds on the already identified organisational hierarchy of a company. Two risk models are produced, one for use at the project level, which considers the sources of uncertainty in the project, and one for use at the company level, which combines the uncertain impacts of the projects it is undertaking, those it is pursuing, and those which it expects will be available in the future. The models have been tested and validated using data collected from projects in their tendering stage. The results of the tests are presented and the findings discussed. Conclusions drawn from the work and recommendations for future work are presented.

Published
1997

78. Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand

Author

Ananworanich, Jintanat, Eller, Leigh Anne, Pinyakorn, Suteeraporn, Kroon, Eugene, Sriplenchan, Somchai, Fletcher, James L.K., Suttichom, Duanghathai, Bryant, Christopher, Trichavaroj, Rapee, Dawson, Peter, Michael, Nelson, Phanuphak, Nittaya, and Robb, Merlin L.

Subjects
HIV infections -- Care and treatment -- Research, Viral load -- Analysis, Antiretroviral agents -- Dosage and administration, Virus replication -- Health aspects -- Analysis -- Research, Health
Abstract

Introduction: The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. However, information comparing viral load (VL) kinetics with and without antiretroviral therapy (ART) in AHI is limited. The knowledge gained could inform preventive strategies aimed at reducing VL during AHI and therapeutic strategies to alter the viral kinetics that may enhance the likelihood of achieving HIV remission. Methods: The analysis utilized VL data captured during the first year of HIV infection from two studies in Thailand: the RV217 study (untreated AHI, 30 participants and 412 visits) and the RV254 study (treated AHI, 235 participants and 2803 visits). Fiebig stages were I/II (HIV RNA+, HIV IgM-) and Fiebig III/IV (HIV IgM+, Western blot-/indeterminate). Data were modelled utilizing spline effects within a linear mixed model, with a random intercept and slope to allow for between-subject variability and adjustment for the differences in variability between studies. The number of knots in the quadratic spline basis functions was determined by comparing models with differing numbers of knots via the Akaike Information Criterion. Models were fit using PROC GLIMMIX in SAS v9.3. Results: At enrolment, there were 24 Fiebig I/II and 6 Fiebig III/IV individuals in the untreated group and 137 Fiebig I/II and 98 Fiebig III/IV individuals in the treated group. Overall, the median age was 27.5 years old, most were male (89%), and CRF01_AE was the most common HIV clade (76%). By day 12 (4 days after ART in RV254), the untreated group had a 2.7-fold higher predicted mean VL level compared to those treated (predicted log VL 6.19 for RV217 and 5.76 for RV254, p = 0.05). These differences increased to 135-fold by day 30 (predicted log VL 4.89 for RV217 and 2.76 for RV254) and 1148-fold by day 120 (predicted log VL 4.68 for RV217 and 1.63 for RV254) (p < 0.0001 for both) until both curves were similarly flat at about day 150 (p = 0.17 between days 150 and 160). The VL trajectories were significantly different between Fiebig I/II and Fiebig III/IV participants when comparing the two groups and within the treated group (p < 0.001 for both). Conclusions: Initiating ART in AHI dramatically changed the trajectory of VL very early in the course of infection that could have implications for reducing transmission potential and enhancing responses to future HIV remission strategies. There is an urgency of initiating ART when acute infection is identified. New and inexpensive strategies to engage and test individuals at high risk for HIV as well as immediate treatment access will be needed to improve the treatment of acute infection globally. Clinical Trial Number: NCT00796146 and NCT00796263 Keywords: HIV; viral load; acute HIV; ART; early treatment; mathematical modelling, Introduction The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. Most notably, viral set point levels in early infection predict time to clinical AIDS [1,2]. [...]

Published
2017
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82. Malaysia’s First Real-Time Fiber Optic Logging with High-Fidelity Distributed Acoustic and Temperature Survey Conveyed Via Slickline: A Solution for Uncertain Downhole Integrity Condition

Author

Shahril, Shakri Shaifi, additional, Mohd Johan, Mohd Alham, additional, Mohd Munir, Dayang Nuriza Z., additional, Mamat, Muhamad Aasif, additional, Paul, Benton, additional, Ahmad Azhari, Ahmad Hafiz, additional, Zainal Abidin, Nurbaizura, additional, Hashim, Haziq, additional, Mahue, Veronique, additional, Pouladi, Behzad, additional, and Dawson, Peter, additional

Published
2022
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87. The Development of a Multi-threaded Multi-objective Tabu Search Algorithm

Author

Dawson, Peter, Parks, Geoff, Jaeggi, Daniel, Molina-Cristobal, Arturo, Clarkson, P. John, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Obayashi, Shigeru, editor, Deb, Kalyanmoy, editor, Poloni, Carlo, editor, Hiroyasu, Tomoyuki, editor, and Murata, Tadahiko, editor

Published
2007
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89. Introduction to Occlusion

Author

Ribeiro-Dasilva, Margarete C., primary, Nguyen, James, additional, Kiskaddon, Keith, additional, and Dawson, Peter E., additional

Published
2016
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95. Helping Plan the Next Pregnancy

Author

Klerman, Lorraine V. and Dawson, Peter

Abstract

When early childhood practitioners are interacting with a mother and her baby, they are focusing, appropriately, on the relationship of the dyad in front of them. However, it is essential to the health and well-being of that family to consider children who may be conceived and born in the future. Research has shown that the well-being of the present family and of this family in the future will be influenced by the wantedness and the timing of subsequent children.

Published
2009

96. Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand

Author

Robb, Merlin L., Eller, Leigh A., Kibuuka, Hannah, Rono, Kathleen, Maganga, Lucas, Nitayaphan, Sorachai, Kroon, Eugene, Sawe, Fred K., Sinei, Samuel, Sriplienchan, Somchai, Jagodzinski, Linda L., Malia, Jennifer, Manak, Mark, de Souza, Mark S., Tovanabutra, Sodsai, Sanders-Buell, Eric, Rolland, Morgane, Dorsey-Spitz, Julie, Eller, Michael A., Milazzo, Mark, Li, Qun, Lewandowski, Andrew, Wu, Hao, Swann, Edith, OʼConnell, Robert J., Peel, Sheila, Dawson, Peter, Kim, Jerome H., and Michael, Nelson L.

Published
2016
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99. Urgent improvements needed to diagnose and manage Lynch syndrome

Author

Monahan, Kevin J, Alsina, Deborah, Bach, Simon, Buchanan, James, Burn, John, Clark, Sue, Dawson, Peter, De Souza, Bianca, Din, Farhat V N, Dolwani, Sunil, Dunlop, Malcolm G, East, James, Evans, Gareth D, Fearnhead, Nicola, Frayling, Ian M, Glynne-Jones, Rob, Hill, James, Houlston, Richard, Hull, Mark, Lalloo, Fiona, Latchford, Andrew, Lishman, Suzy, Quirke, Phil, Rees, Colin, Rutter, Matt, Sasieni, Peter, Senapati, Asha, Speake, Doug, Thomas, Huw, and Tomlinson, Ian

Published
2017
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