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3,183 results on '"Davidson, Andrew"'

52. The seroprevalence of SARS-CoV-2-specific antibodies in Australian children: a cross sectional study

Author

Koirala, Archana, primary, McRae, Jocelynne, additional, Britton, Philip N, additional, Downes, Marnie, additional, Prasad, Shayal A, additional, Nicholson, Suellen, additional, Winkler, Noni E, additional, O'Sullivan, Matthew, additional, Gondalwala, Fatima, additional, Castellano, Cecile, additional, Carey, Emma, additional, Hendry, Alexandra, additional, Crawford, Nigel, additional, Wadia, Ushma Dilesh, additional, Richmond, Peter, additional, Marshall, Helen S, additional, Clark, Julia E, additional, Francis, Joshua R, additional, Carr, Jeremy, additional, Bartlett, Adam, additional, McMullan, Brendan, additional, Skowno, Justin, additional, Hannah, Donald, additional, Davidson, Andrew, additional, von Ungern-Sternbeg, Britta S, additional, Lee-Archer, Paul, additional, Burgoyne, Laura Lee-anne, additional, Waugh, Edith Bodnar, additional, Carlin, John B, additional, Naing, Zin, additional, Kerly, Nicole, additional, McMinn, Alissa, additional, Hunter, Guillian, additional, Heath, Christine, additional, D'Angelo, Natascha, additional, Finucane, Carolyn, additional, Francis, Laura Anne, additional, Dougherty, Sonia, additional, Rawlinson, William, additional, Karapanagiotidis, Theo, additional, Cain, Natalie, additional, Brizuela, Rianne, additional, Blyth, Christopher C, additional, Wood, Nicholas, additional, and Macartney, Kristine, additional

Published
2024
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53. Long Term Outcomes of Randomised Early Exposure to Repeated General Anesthesia in Infants with Cystic Fibrosis

Author

Wainwright, Claire, primary, Vidmar, Suzanna, additional, Anderson, Vicki, additional, Bourgeat, Pierrick, additional, Byrnes, Catherine A., additional, Carlin, John Brooke, additional, Cheney, Joyce, additional, Cooper, Peter, additional, Davidson, Andrew, additional, Gailer, Nicholas, additional, Grayson-Collins, Jasmin, additional, Quittner, Alexandra L., additional, Robertson, Colin, additional, Salvado, Olivier, additional, Zannino, Dianna, additional, and Armstrong, Daniel, additional

Published
2024
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56. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Author

Peacock, Thomas P., Goldhill, Daniel H., Zhou, Jie, Baillon, Laury, Frise, Rebecca, Swann, Olivia C., Kugathasan, Ruthiran, Penn, Rebecca, Brown, Jonathan C., Sanchez-David, Raul Y., Braga, Luca, Williamson, Maia Kavanagh, Hassard, Jack A., Staller, Ecco, Hanley, Brian, Osborn, Michael, Giacca, Mauro, Davidson, Andrew D., Matthews, David A., and Barclay, Wendy S.

Published
2021
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58. Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila

Author

Davidson, Andrew J., Heron, Rosalind, Das, Jyotirekha, Overholtzer, Michael, and Wood, Will

Abstract

Ferroptosis is a distinct form of necrotic cell death caused by overwhelming lipid peroxidation, and emerging evidence indicates a major contribution to organ damage in multiple pathologies. However, ferroptosis has not yet been visualized in vivo due to a lack of specific probes, which has severely limited the study of how the immune system interacts with ferroptotic cells and how this process contributes to inflammation. Consequently, whether ferroptosis has a physiological role has remained a key outstanding question. Here we identify a distinct, ferroptotic-like, necrotic cell death occurring in vivo during wounding of the Drosophilaembryo using live imaging. We further demonstrate that macrophages rapidly engage these necrotic cells within the embryo but struggle to engulf them, leading to prolonged, frustrated phagocytosis and frequent corpse disintegration. Conversely, suppression of the ferroptotic programme during wounding delays macrophage recruitment to the injury site, pointing to conflicting roles for ferroptosis during inflammation in vivo.

Published
2024
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59. Isoelectric Electroencephalography in Infants and Toddlers during Anesthesia for Surgery: An International Observational Study

Author

Yuan, Ian, Xu, Ting, Skowno, Justin, Zhang, Bingqing, Davidson, Andrew, von Ungern-Sternberg, Britta S., Sommerfield, David, Zhang, Jianmin, Song, Xingrong, Zhang, Mazhong, Zhao, Ping, Liu, Huacheng, Jiang, Yifei, Zuo, Yunxia, de Graaff, Jurgen C., Vutskits, Laszlo, Olbrecht, Vanessa A., Szmuk, Peter, Kurth, Charles D., Menezes, Minal, Sheppard, Suzette, Gao, ZhengZheng, Lei, DongXu, Zheng, Jijian, Ding, Mengmeng, Chen, Panpan, Du, Bin, Bhuju, Abhusani, van Hoorn, Camille, Roden, Emilie, Georgostathi, Georgia, Richter, Adam, Ampah, Steve B., Huh, Jimmy W., Lang, Shih-Shan, Missett, Richard M., Kirschen, Matthew P., Topjian, Alexis, Hu, Paula, Saynhalath, Rita, Efune, Proshad, and Alex, Gijo

Published
2022
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60. Gunrock: A High-Performance Graph Processing Library on the GPU

Author

Wang, Yangzihao, Davidson, Andrew, Pan, Yuechao, Wu, Yuduo, Riffel, Andy, and Owens, John D.

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, D.1.3
Abstract

For large-scale graph analytics on the GPU, the irregularity of data access and control flow, and the complexity of programming GPUs have been two significant challenges for developing a programmable high-performance graph library. "Gunrock", our graph-processing system designed specifically for the GPU, uses a high-level, bulk-synchronous, data-centric abstraction focused on operations on a vertex or edge frontier. Gunrock achieves a balance between performance and expressiveness by coupling high performance GPU computing primitives and optimization strategies with a high-level programming model that allows programmers to quickly develop new graph primitives with small code size and minimal GPU programming knowledge. We evaluate Gunrock on five key graph primitives and show that Gunrock has on average at least an order of magnitude speedup over Boost and PowerGraph, comparable performance to the fastest GPU hardwired primitives, and better performance than any other GPU high-level graph library., Comment: 14 pages, accepted by PPoPP'16 (removed the text repetition in the previous version v5)

Published
2015
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61. Regional and local factors interact to shape colonization and extinction dynamics of invasive Hydrilla verticillata in a patchy landscape.

Author

Armstrong, Joshua T., Bulluck, Lesley P., Davidson, Andrew T., Stunkle, Charles Ryland, and Vonesh, James R.

Subjects
HYDRILLA, COLONIZATION (Ecology), SPECIES distribution, DYNAMIC models, LANDSCAPES, AQUATIC plants
Abstract

Understanding the response of species to global change requires disentangling the drivers of their distributions across landscapes. Colonization and extinction processes, shaped by the interplay of landscape‐level and local patch‐level factors, are key determinants of these distributions. However, disentangling the influence of these factors, when larger‐scale processes manifest at local scales, remains a challenge. We addressed this challenge by investigating the colonization and extinction dynamics of the aquatic plant, Hydrilla verticillata, in a complex riverine rock pool system. This system, with hundreds of rock pools experiencing varying flooding frequencies, provided a natural laboratory to examine how a single landscape‐level disturbance can differentially impact colonization and extinction depending on local patch characteristics to shape species distributions. Using 5 years of data across over 500 sites and more than 5000 surveys, we employed dynamic occupancy models to model colonization, extinction, and changes in Hydrilla patch occupancy while accounting for imperfect detection. Our results revealed that larger, infrequently flooded pools closer to the river were more likely to be colonized. In contrast, local extinction of Hydrilla was more likely in smaller pools closer to the river that flooded frequently. These findings underscore the importance of considering context‐dependence in species distribution models. The same landscape‐level disturbance (flooding) had opposing effects on colonization and extinction, with the direction and magnitude of these effects varying with local patch characteristics. Our study highlights the need for integrating local and landscape‐level factors, and considering how larger‐scale processes play out at the patch level, to understand the complex dynamics that shape species distributions. [ABSTRACT FROM AUTHOR]

Published
2024
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62. Headache in Patients with Sellar Disease: Clinicomorphological Predictors of Headache and the Outcome of Endoscopic Transsphenoidal Surgery.

Author

Joseph, Maria, Alvarado, Raquel, Jonker, Benjamin P., Winder, Mark J., Earls, Peter, Campbell, Raewyn, Kalish, Larry H., Sacks, Raymond, Davidson, Andrew S., McCormack, Ann, and Harvey, Richard J.

Subjects
ENDOSCOPIC surgery, PRIMARY headache disorders, HEADACHE, SPHENOID sinus, MIGRAINE
Abstract

Objectives Sellar pathologies are frequently found on imaging performed to investigate headache. However, both headache and incidental sellar lesions are common. Hence, this study prospectively examined headache prevalence, phenotype, and severity in patients with sellar pathologies and the impact of transsphenoidal surgery on headache. Methods Patients undergoing transsphenoidal resection of sellar lesions were consecutively recruited. At baseline, participants were defined as having headache or not and headache phenotype was characterized using validated questionnaires. Headache severity was assessed at baseline and 6 months postoperatively using the Headache Impact Test-6 (HIT-6) and Migraine Disability Assessment Score (MIDAS). Tumor characteristics were defined using radiological, histological, and endocrine factors. Primary outcomes included baseline headache prevalence and severity and headache severity change at 6 months postoperatively. Correlation between headache and radiological, histological, and endocrine characteristics was also of interest. Results Sixty participants (62% female, 47.1 ± 18.6 years) were recruited. Sixty-three percent possessed baseline headache. HIT-6 scores were higher in patients with primary headache risk factors, including younger age (R 2 = −0.417, p = 0.010), smoking history (63.31 ± 7.93 vs 54.44 ± 9.21, p = 0.0060), and family headache history (68.13 ± 7.01 vs 54.94 ± 9.11, p = 0.0030). Headaches were more common in patients with dural invasion (55.70 ± 12.14 vs 47.18 ± 10.15, p = 0.027) and sphenoid sinus invasion (58.87 ± 8.97 vs 51.29 ± 10.97, p = 0.007). Postoperative severity scores improved more with higher baseline headache severity (HIT-6: R 2 = −0.682, p < 0.001, MIDAS: R 2 = −0.880, p < 0.0010) and dural invasion (MIDAS: −53.00 ± 18.68 vs 12.00 ± 17.54, p = 0.0030). Conclusion Headaches in sellar disease are likely primary disorders triggered or exacerbated by sellar pathology. These may respond to surgery, particularly in patients with severe headache and dural invasion. [ABSTRACT FROM AUTHOR]

Published
2024
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63. Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19.

Author

Clark, Jordan J., Penrice-Randal, Rebekah, Sharma, Parul, Dong, Xiaofeng, Pennington, Shaun H., Marriott, Amy E., Colombo, Stefano, Davidson, Andrew, Kavanagh Williamson, Maia, Matthews, David A., Turtle, Lance, Prince, Tessa, Hughes, Grant L., Patterson, Edward I., Shawli, Ghada, Mega, Daniele F., Subramaniam, Krishanthi, Sharp, Jo, Turner, Joseph D., and Biagini, Giancarlo A.

Subjects
SARS-CoV-2, INFLUENZA viruses, VIRUS diseases, INFLUENZA A virus, LABORATORY mice
Abstract

COVID-19 is a spectrum of clinical symptoms in humans caused by infection with SARS-CoV-2. The coalescence of SARS-CoV-2 with seasonal respiratory viruses, particularly influenza viruses, is a global health concern. To understand this, transgenic mice expressing the human ACE2 receptor (K18-hACE2) were infected with influenza A virus (IAV) followed by SARS-CoV-2 and the host response and effect on virus biology was compared to K18-hACE2 mice infected with IAV or SARS-CoV-2 alone. The sequentially infected mice showed reduced SARS-CoV-2 RNA synthesis, yet exhibited more rapid weight loss, more severe lung damage and a prolongation of the innate response compared to the singly infected or control mice. Sequential infection also exacerbated the extrapulmonary encephalitic manifestations associated with SARS-CoV-2 infection. Conversely, prior infection with a commercially available, multivalent live-attenuated influenza vaccine (Fluenz Tetra) elicited the same reduction in SARS-CoV-2 RNA synthesis, albeit without the associated increase in disease severity. This suggests that the innate immune response stimulated by IAV inhibits SARS-CoV-2. Interestingly, infection with an attenuated, apathogenic influenza vaccine does not result in an aberrant immune response and enhanced disease severity. Taken together, the data suggest coinfection ('twinfection') is deleterious and mitigation steps should be instituted as part of the comprehensive public health and management strategy of COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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64. GPU Multisplit

Author

Ashkiani, Saman, Davidson, Andrew, Meyer, Ulrich, and Owens, John D

Subjects
Multisplit, GPU, primitive algorithms, warp synchronous programming
Abstract

Multisplit is a broadly useful parallel primitive that permutes its input data into contiguous buckets or bins, where the function that categorizes an element into a bucket is provided by the programmer.Due to the lack of an efficient multisplit on GPUs, programmers often choose to implement multisplit with a sort. However, sort does more work than necessary to implement multisplit, and is thus inefficient.In this work, we provide a parallel model and multiple implementations for the multisplit problem. Our principal focus is multisplit for a small number of buckets.In our implementations, we exploit the computational hierarchy of the GPU to perform most of the work locally, with minimal usage of global operations.We also use warp-synchronous programming models to avoid branch divergence and reduce memory usage, as well as hierarchical reordering of input elements to achieve better coalescing of global memory accesses.On an NVIDIA K40c GPU, for key-only (key-value) multisplit, we demonstrate a 3.0--6.7x (4.4--8.0x) speedup over radix sort, and achieve a peak throughput of 10.0 G keys/s.

Published
2016

65. Gunrock: A High-Performance Graph Processing Library on the GPU

Author

Wang, Yangzihao, Davidson, Andrew, Pan, Yuechao, Wu, Yuduo, Riffel, Andy, and Owens, John D.

Subjects
Graph Processing, GPU, Runtime Framework
Abstract

For large-scale graph analytics on the GPU, the irregularity of dataaccess/control flow and the complexity of programming GPUs have been twosignificant challenges for developing a programmable high-performance graphlibrary. "Gunrock," our high-level bulk-synchronous graph-processing systemtargeting the GPU, takes a new approach to abstracting GPU graph analytics:rather than designing an abstraction around computation, Gunrock insteadimplements a novel data-centric abstraction centered on operations ona vertex or edge frontier. Gunrock achieves a balance between performance andexpressiveness by coupling high-performance GPU computing primitives andoptimization strategies with a high-level programming model that allowsprogrammers to quickly develop new graph primitives with small code size andminimal GPU programming knowledge. We evaluate Gunrock on five graphprimitives (BFS, BC, SSSP, CC, and PageRank) and show that Gunrock has onaverage at least an order of magnitude speedup over Boost and PowerGraph,comparable performance to the fastest GPU hardwired primitives, and betterperformance than any other GPU high-level graph library.

Published
2016

66. OP85 Cost Effectiveness Of Prednisolone To Treat Bell’s Palsy In Children: An Economic Evaluation Alongside A Randomized Controlled Trial

Author

Xiong, Xiuqin, primary, Huang, Li, additional, Herd, David, additional, Borland, Meredith, additional, Davidson, Andrew, additional, Hearps, Stephen, additional, Mackay, Mark, additional, Lee, Katherine, additional, Dalziel, Stuart, additional, Dalziel, Kim, additional, Cheek, John, additional, and Babl, Franz, additional

Published
2023
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70. The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

Author

Bigotti, Martia Giulia, primary, Klein, Katja, additional, Gan, Esther S, additional, Anastasina, Maria, additional, Andersson, Simon, additional, Vapalahti, Olli, additional, Katajisto, Pekka, additional, Erdmann, Maximilian, additional, Davidson, Andrew D., additional, Butcher, Sarah Jane, additional, Collinson, Ian, additional, Ooi, Eng Eong, additional, Balistreri, Giuseppe, additional, Brancaccio, Andrea, additional, and Yamauchi, Yohei, additional

Published
2023
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72. Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

Author

Pittet, Laure F., primary, Moore, Cecilia L., additional, McDonald, Ellie, additional, Barry, Simone, additional, Bonten, Marc, additional, Campbell, John, additional, Croda, Julio, additional, Dalcolmo, Margareth, additional, Davidson, Andrew, additional, Douglas, Mark W., additional, Gardiner, Kaya, additional, Gwee, Amanda, additional, Jardim, Bruno, additional, Lacerda, Marcus V.G., additional, Lucas, Michaela, additional, Lynn, David J., additional, Manning, Laurens, additional, de Oliveira, Roberto D., additional, Perrett, Kirsten P., additional, Prat-Aymerich, Cristina, additional, Richmond, Peter C., additional, Rocha, Jorge L., additional, Rodriguez-Baño, Jesus, additional, Warris, Adilia, additional, Wood, Nicholas J., additional, Messina, Nicole L., additional, Curtis, Nigel, additional, Jamieson, Tenaya, additional, Messina, Nicole, additional, Morawakage, Thilanka, additional, Perlen, Susan, additional, Perrett, Kirsten, additional, Pittet, Laure, additional, Sastry, Amber, additional, Teo, Jia Wei, additional, Orsini, Francesca, additional, Lee, Katherine, additional, Moore, Cecilia, additional, Vidmar, Suzanna, additional, Ali, Rashida, additional, Dunn, Ross, additional, Edler, Peta, additional, Gell, Grace, additional, Goodall, Casey, additional, Hall, Richard, additional, Krastev, Ann, additional, La, Nathan, additional, McPhate, Nick, additional, Nguyen, Thao, additional, Ren, Jack, additional, Stevens, Luke, additional, Alamrousi, Ahmed, additional, Bonnici, Rhian, additional, Dang, Thanh, additional, Germano, Susie, additional, Hua, Jenny, additional, McElroy, Rebecca, additional, Razmovska, Monica, additional, Reddiex, Scott, additional, Wang, Xiaofang, additional, Anderson, Jeremy, additional, Azzopardi, Kristy, additional, Bennett-Wood, Vicki, additional, Czajko, Anna, additional, Mazarakis, Nadia, additional, McCafferty, Conor, additional, Oppedisano, Frances, additional, Ortika, Belinda, additional, Pell, Casey, additional, Spry, Leena, additional, Toh, Ryan, additional, Velagapudi, Sunitha, additional, Vlahos, Amanda, additional, Wee-Hee, Ashleigh, additional, Ramos, Pedro, additional, De La Cruz, Karina, additional, Gamage, Dinusha, additional, Karunanayake, Anushka, additional, Mezzetti, Isabella, additional, Ong, Benjamin, additional, Singh, Ronita, additional, Sooriyarachchi, Enoshini, additional, Nicholson, Suellen, additional, Cain, Natalie, additional, Brizuela, Rianne, additional, Huang, Han, additional, Abruzzo, Veronica, additional, Bealing, Morgan, additional, Bimboese, Patricia, additional, Bowes, Kirsty, additional, Burrell, Emma, additional, Chan, Joyce, additional, Cushnahan, Jac, additional, Elborough, Hannah, additional, Elkington, Olivia, additional, Fahey, Kieran, additional, Fernandez, Monique, additional, Flynn, Catherine, additional, Fowler, Sarah, additional, Andrit, Marie Gentile, additional, Gladanac, Bojana, additional, Hammond, Catherine, additional, Ma, Norine, additional, Macalister, Sam, additional, Milojevic, Emmah, additional, Mojeed, Jesutofunmi, additional, Nguyen, Jill, additional, O'Donnell, Liz, additional, Olivier, Nadia, additional, Ooi, Isabelle, additional, Reynolds, Stephanie, additional, Shen, Lisa, additional, Sherry, Barb, additional, Spotswood, Judith, additional, Wedderburn, Jamie, additional, Younes, Angela, additional, Legge, Donna, additional, Bell, Jason, additional, Cheah, Jo, additional, Cobbledick, Annie, additional, Lim, Kee, additional, Elia, Sonja, additional, Addlem, Lynne, additional, Bourke, Anna, additional, Brophy, Clare, additional, Henare, Nadine, additional, Jenkins, Narelle, additional, Machingaifa, Francesca, additional, Miller, Skye, additional, Mitchell, Kirsten, additional, Pitkin, Sigrid, additional, Wall, Kate, additional, Villanueva, Paola, additional, Crawford, Nigel, additional, Norton, Wendy, additional, Tan, Niki, additional, Chengodu, Thilakavathi, additional, Dawson, Diane, additional, Gordon, Victoria, additional, Korman, Tony, additional, O'Bryan, Jess, additional, Agius, Sophie, additional, Bannister, Samantha, additional, Bucholc, Jess, additional, Burns, Alison, additional, Camesella, Beatriz, additional, Carlin, John, additional, Ciaverella, Marianna, additional, Curtis, Maxwell, additional, Firth, Stephanie, additional, Guo, Christina, additional, Hannan, Matthew, additional, Hill, Erin, additional, Joshi, Sri, additional, Lieschke, Katherine, additional, Mathers, Megan, additional, Odoi, Sasha, additional, Rak, Ashleigh, additional, Richards, Chris, additional, Steve, Leah, additional, Stewart, Carolyn, additional, Sudbury, Eva, additional, Thomson, Helen, additional, Watts, Emma, additional, Williams, Fiona, additional, Young, Angela, additional, Glenn, Penny, additional, Kaynes, Andrew, additional, Philippart De Floy, Amandine, additional, Buchanan, Sandy, additional, Sondag, Thijs, additional, Xie, Ivy, additional, Edmund, Harriet, additional, Byrne, Bridie, additional, Keeble, Tom, additional, Ngien, Belle, additional, Noonan, Fran, additional, Wearing-Smith, Michelle, additional, Clarke, Alison, additional, Davies, Pemma, additional, Eastwood, Oliver, additional, Ellinghaus, Alric, additional, Ghieh, Rachid, additional, Hilton, Zahra, additional, Jennings, Emma, additional, Kakkos, Athina, additional, Liang, Iris, additional, Nicol, Katie, additional, O'Callaghan, Sally, additional, Osman, Helen, additional, Rajaram, Gowri, additional, Ratcliffe, Sophia, additional, Rayner, Victoria, additional, Salmon, Ashleigh, additional, Scheppokat, Angela, additional, Stevens, Aimee, additional, Street, Rebekah, additional, Toogood, Nicholas, additional, Wood, Nicholas, additional, Bahaduri, Twinkle, additional, Baulman, Therese, additional, Byrne, Jennifer, additional, Carter, Candace, additional, Corbett, Mary, additional, Dao, Aiken, additional, Desylva, Maria, additional, Dunn, Andrew, additional, Gardiner, Evangeline, additional, Joyce, Rosemary, additional, Kandasamy, Rama, additional, Munns, Craig, additional, Pelayo, Lisa, additional, Sharma, Ketaki, additional, Sterling, Katrina, additional, Uren, Caitlin, additional, Colaco, Clinton, additional, Douglas, Mark, additional, Hamilton, Kate, additional, Bartlett, Adam, additional, McMullan, Brendan, additional, Palasanthiran, Pamela, additional, Williams, Phoebe, additional, Beardsley, Justin, additional, Bergant, Nikki, additional, Lagunday, Renier, additional, Overton, Kristen, additional, Post, Jeffrey, additional, Al-Hindawi, Yasmeen, additional, Barney, Sarah, additional, Byrne, Anthony, additional, Mead, Lee, additional, Plit, Marshall, additional, Lynn, David, additional, Benson, Saoirse, additional, Blake, Stephen, additional, Botten, Rochelle, additional, Chern, Tee Yee, additional, Eden, Georgina, additional, Griffith, Liddy, additional, James, Jane, additional, Lynn, Miriam, additional, Markow, Angela, additional, Sacca, Domenic, additional, Stevens, Natalie, additional, Wesselingh, Steve, additional, Doran, Catriona, additional, Sawka, Alice, additional, Evans, Sue, additional, Goodchild, Louise, additional, Heath, Christine, additional, Krieg, Meredith, additional, Marshall, Helen, additional, McMillan, Mark, additional, Walker, Mary, additional, Richmond, Peter, additional, Amenyogbe, Nelly, additional, Anthony, Christina, additional, Arnold, Annabelle, additional, Arrowsmith, Beth, additional, Ben-Othman, Rym, additional, Clark, Sharon, additional, Dunnill, Jemma, additional, Eiffler, Nat, additional, Ewe, Krist, additional, Finucane, Carolyn, additional, Flynn, Lorraine, additional, Gibson, Camille, additional, Hartnell, Lucy, additional, Hollams, Elysia, additional, Hutton, Heidi, additional, Jarvis, Lance, additional, Jones, Jane, additional, Jones, Jan, additional, Jones, Karen, additional, Kent, Jennifer, additional, Kollmann, Tobias, additional, Lalich, Debbie, additional, Lee, Wenna, additional, Lim, Rachel, additional, McAlister, Sonia, additional, McDonald, Fiona, additional, Meehan, Andrea, additional, Minhaj, Asma, additional, Montgomery, Lisa, additional, O'Donnell, Melissa, additional, Ong, Jaslyn, additional, Ong, Joanne, additional, Parkin, Kimberley, additional, Perez, Glady, additional, Power, Catherine, additional, Rezazadeh, Shadie, additional, Richmond, Holly, additional, Rogers, Sally, additional, Schultz, Nikki, additional, Shave, Margaret, additional, Skut, Patrycja, additional, Stiglmayer, Lisa, additional, Truelove, Alexandra, additional, Wadia, Ushma, additional, Wallace, Rachael, additional, Waring, Justin, additional, England, Michelle, additional, Latkovic, Erin, additional, Herrmann, Susan, additional, Lacerda, Marcus, additional, Andrade, Paulo Henrique, additional, Barbosa, Fabiane Bianca, additional, Barros, Dayanne, additional, Brasil, Larissa, additional, Capella, Ana Greyce, additional, Castro, Ramon, additional, Costa, Erlane, additional, de Souza, Dilcimar, additional, Dias, Maianne, additional, Dias, José, additional, Ferreira, Klenilson, additional, Figueiredo, Paula, additional, Freitas, Thamires, additional, Furtado, Ana Carolina, additional, Gama, Larissa, additional, Godinho, Vanessa, additional, Gouy, Cintia, additional, Hinojosa, Daniele, additional, Jardim, Tyane, additional, Junior, Joel, additional, Lima, Augustto, additional, Maia, Bernardo, additional, Marins, Adriana, additional, Mazurega, Kelry, additional, Medeiros, Tercilene, additional, Melo, Rosangela, additional, Moraes, Marinete, additional, Nascimento, Elizandra, additional, Neves, Juliana, additional, Oliveira, Maria Gabriela, additional, Oliveira, Thais, additional, Oliveira, Ingrid, additional, Otsuka, Arthur, additional, Paes, Rayssa, additional, Pereira, Handerson, additional, Pereira, Gabrielle, additional, Prado, Christiane, additional, Queiroz, Evelyn, additional, Rodrigues, Laleyska, additional, Rodrigues, Bebeto, additional, Sampaio, Vanderson, additional, Santos, Anna Gabriela, additional, Santos, Daniel, additional, Santos, Tilza, additional, Santos, Evelyn, additional, Sartim, Ariandra, additional, Silva, Ana Beatriz, additional, Silva, Juliana, additional, Silva, Emanuelle, additional, Simão, Mariana, additional, Soares, Caroline, additional, Sousa, Antonny, additional, Trindade, Alexandre, additional, Val, Fernando, additional, Vasconcelos, Adria, additional, Vasconcelos, Heline, additional, Abreu, Carolinne, additional, Almeida, Katya Martinez, additional, Bitencourt de Andrade, Camila, additional, Campos Angelo, Jhenyfer Thalyta, additional, Gonçalvez de Araújo Arcanjo, Ghislaine, additional, Silva Menezes Arruda, Bianca Maria, additional, Ayala, Wellyngthon Espindola, additional, Refosco Barbosa, Adelita Agripina, additional, Vieira Batista, Felipe Zampieri, additional, de Morais Batista, Fabiani, additional, de Jesus Costa, Miriam, additional, Croda, Mariana Garcia, additional, Alves da Cruz, Lais, additional, Pereira Diogo, Roberta Carolina, additional, Dutra Escobar, Rodrigo Cezar, additional, Fernandes, Iara Rodrigues, additional, Figueiredo, Leticia Ramires, additional, Cavalcanti Gonçalves, Leandro Galdino, additional, Lahdo, Sarita, additional, Lencina, Joyce dos Santos, additional, Teodoro de Lima, Guilherme, additional, Matos, Larissa Santos, additional, Leopoldina Meireles, Bruna Tayara, additional, Moreira, Debora Quadros, additional, Silva Muranaka, Lilian Batista, additional, de Oliveira, Adriely, additional, Warszawski de Oliveira, Karla Regina, additional, Vieira de Oliveira, Matheus, additional, Dias de Oliveira, Roberto, additional, Souza de Almeida dos Reis Pereira, Andrea Antonia, additional, Puga, Marco, additional, Ramos, Caroliny Veron, additional, Souza da Rosa, Thaynara Haynara, additional, Lopes dos Santos, Karla, additional, Ribeiro dos Santos, Claudinalva, additional, Leopoldina dos Santos, Dyenyffer Stéffany, additional, Santos, Karina Marques, additional, Pereira da Silva, Paulo César, additional, Rocha da Silva, Paulo Victor, additional, Silva, Débora dos Santos, additional, Vieira da Silva, Patricia, additional, Freitas da Rosa Soares, Bruno, additional, Sperotto, Mariana Gazzoni, additional, Tadokoro, Mariana Mayumi, additional, Tsuha, Daniel, additional, Ramos Vieira, Hugo Miguel, additional, Pretti Dalcolmo, Margareth Maria, additional, Lopes Alves da Paixão, Cíntia Maria, additional, Corrêa E Castro, Gabriela, additional, Collopy, Simone Silva, additional, da Costa Silva, Renato, additional, Almeida da Silveira, Samyra, additional, Da-Cruz, Alda Maria, additional, Maria da Silva Passos de Carvalho, Alessandra, additional, de Cássia Batista, Rita, additional, Silva De Freitas, Maria Luciana, additional, Gerhardt de Oliveira Ferreira, Aline, additional, Conceição de Souza, Ana Paula, additional, Doblas, Paola Cerbino, additional, Alcoforado da Silva dos Santos, Ayla, additional, Cristine de Moraes dos Santos, Vanessa, additional, Alves dos Santos Gomes, Dayane, additional, Fortunato, Anderson Lage, additional, Gomes-Silva, Adriano, additional, Gonçalves, Monique Pinto, additional, Garcia Meireless Junior, Paulo Leandro, additional, Martins da Costa Carvalho, Estela, additional, Motta, Fernando do Couto, additional, Olivo de Mendonça, Ligia Maria, additional, Pandine, Girlene dos Santos, additional, Plácido Pereira, Rosa Maria, additional, Maia, Ivan Ramos, additional, Luiz da Rocha, Jorge, additional, Paiva Romano, João Victor, additional, Santos, Glauce dos, additional, Fernandes da Silva, Erica, additional, Mendonça Teixeira de Siqueira, Marilda Agudo, additional, Prudêncio Soares, Ágatha Cristinne, additional, Arroyo, Sandra Franch, additional, Besten, Henny Ophorst-den, additional, Boon, Anna, additional, Brakke, Karin M., additional, Janssen, Axel, additional, Koopmans, Marijke A.H., additional, Lemmens, Toos, additional, Leurink, Titia, additional, Septer-Bijleveld, Engelien, additional, Stadhouders, Kimberly, additional, Troeman, Darren, additional, van der Waal, Marije, additional, van Opdorp, Marjoleine, additional, van Sluis, Nicolette, additional, Wolters, Beatrijs, additional, Kluytmans, Jan, additional, Romme, Jannie, additional, van den Bijllaardt, Wouter, additional, van Mook, Linda, additional, Rijen, M.M.L (Miranda) van, additional, Filius, P.M.G., additional, Gisolf, Jet, additional, Greven, Frances, additional, Huijbens, Danique, additional, Hassing, Robert Jan, additional, Pon, R.C., additional, Preijers, Lieke, additional, van Leusen, J.H., additional, Verheij, Harald, additional, Boersma, Wim, additional, Brans, Evelien, additional, Kloeg, Paul, additional, Molenaar-Groot, Kitty, additional, Nguyen, Nhat Khanh, additional, Paternotte, Nienke, additional, Rol, Anke, additional, Stooper, Lida, additional, Dijkstra, Helga, additional, Eggenhuizen, Esther, additional, Huijs, Lucas, additional, Moorlag, Simone, additional, Netea, Mihai, additional, Pranger, Eva, additional, Taks, Esther, additional, Oever, Jaap ten, additional, Heine, Rob ter, additional, Blauwendraat, Kitty, additional, Meek, Bob, additional, Erkaya, Isil, additional, Harbech, Houda, additional, Roescher, Nienke, additional, Peeters, Rifka, additional, Riele, Menno te, additional, Zhou, Carmen, additional, Calbo, Esther, additional, Marti, Cristina Badia, additional, Palomares, Emma Triviño, additional, Porcuna, Tomás Perez, additional, Barriocanal, Anabel, additional, Barriocanal, Ana Maria, additional, Casas, Irma, additional, Dominguez, Jose, additional, Esteve, Maria, additional, Lacoma, Alicia, additional, Latorre, Irene, additional, Molina, Gemma, additional, Molina, Barbara, additional, Rosell, Antoni, additional, Vidal, Sandra, additional, Barrera, Lydia, additional, Bustos, Natalia, additional, Calderón, Ines Portillo, additional, Campos, David Gutierrez, additional, Carretero, Jose Manuel, additional, Castellano, Angel Dominguez, additional, Compagnone, Renato, additional, Ramirez de Arellano, Encarnacion, additional, Serna, Almudena de la, additional, Dolores del Toro Lopez, Maria, additional, Clement Espindola, Marie-Alix, additional, Martin Gutierrez, Ana Belen, additional, Hernandez, Alvaro Pascual, additional, Jiménez, Virginia Palomo, additional, Moreno, Elisa, additional, Navarrete, Nicolas, additional, Paño, Teresa Rodriguez, additional, Rodríguez-Baño, Jesús, additional, Tristán, Enriqueta, additional, Rios Villegas, Maria Jose, additional, Garces, Atsegiñe Canga, additional, Amo, Erika Castro, additional, Guerrero, Raquel Coya, additional, Goikoetxea, Josune, additional, Jorge, Leticia, additional, Perez, Cristina, additional, Fariñas Álvarez, María Carmen, additional, Cuadra, Manuel Gutierrez, additional, Arnaiz de las Revillas Almajano, Francisco, additional, Garcia, Pilar Bohedo, additional, Poderos, Teresa Giménez, additional, Rico, Claudia González, additional, Sanchez, Blanca, additional, Valero, Olga, additional, Vega, Noelia, additional, Barnes, Anna, additional, Catterick, Helen, additional, Cranston, Tim, additional, Dawe, Phoebe, additional, Fletcher, Emily, additional, Fouracre, Liam, additional, Gifford, Alison, additional, Kirkwood, John, additional, Martin, Christopher, additional, McAnew, Amy, additional, Mitchell, Marcus, additional, Newman, Georgina, additional, O'Connell, Abby, additional, Onysk, Jakob, additional, Quinn, Lynne, additional, Rhodes, Shelley, additional, Stone, Samuel, additional, Symons, Lorrie, additional, Tripp, Harry, additional, Watkins, Darcy, additional, Whale, Bethany, additional, Harding, Alex, additional, Lockhart, Gemma, additional, Sidaway-Lee, Kate, additional, Hilton, Sam, additional, Manton, Sarah, additional, Webber-Rookes, Daniel, additional, Winder, Rachel, additional, Moore, James, additional, Bateman, Freya, additional, Gibbons, Michael, additional, Knight, Bridget, additional, Moss, Julie, additional, Statton, Sarah, additional, Studham, Josephine, additional, Hall, Lydia, additional, Moyle, Will, additional, and Venton, Tamsin, additional

Published
2023
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81. k-d Darts: Sampling by k-Dimensional Flat Searches

Author

Ebeida, Mohamed S., Patney, Anjul, Mitchell, Scott A., Dalbey, Keith R., Davidson, Andrew A., and Owens, John D.

Subjects
Computer Science - Graphics, I.3.5
Abstract

We formalize the notion of sampling a function using k-d darts. A k-d dart is a set of independent, mutually orthogonal, k-dimensional subspaces called k-d flats. Each dart has d choose k flats, aligned with the coordinate axes for efficiency. We show that k-d darts are useful for exploring a function's properties, such as estimating its integral, or finding an exemplar above a threshold. We describe a recipe for converting an algorithm from point sampling to k-d dart sampling, assuming the function can be evaluated along a k-d flat. We demonstrate that k-d darts are more efficient than point-wise samples in high dimensions, depending on the characteristics of the sampling domain: e.g. the subregion of interest has small volume and evaluating the function along a flat is not too expensive. We present three concrete applications using line darts (1-d darts): relaxed maximal Poisson-disk sampling, high-quality rasterization of depth-of-field blur, and estimation of the probability of failure from a response surface for uncertainty quantification. In these applications, line darts achieve the same fidelity output as point darts in less time. We also demonstrate the accuracy of higher dimensional darts for a volume estimation problem. For Poisson-disk sampling, we use significantly less memory, enabling the generation of larger point clouds in higher dimensions., Comment: 19 pages 16 figures

Published
2013
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88. The role of WASP family members in Dictyostelium discoideum cell migration

Author

Davidson, Andrew J.

Subjects
572, QH301 Biology, QH426 Genetics
Abstract

The WASP family of proteins are nucleation-promoting factors that dictate the temporal and spatial dynamics of Arp2/3 complex recruitment, and hence actin polymerisation. Consequently, members of the WASP family, such as SCAR/WAVE and WASP, drive processes such as pseudopod formation and clathrin-mediated endocytosis, respectively. However, the nature of functional specificity or overlap of WASP family members is controversial and also appears to be contextual. For example, some WASP family members appear capable of assuming each other’s roles in cells that are mutant for certain family members. How the activity of each WASP family member is normally limited to promoting the formation of a specific subset of actin-based structures and how they are able to escape these constraints in order to substitute for one another, remain unanswered questions. Furthermore, how the WASP family members collectively contribute to complex processes such as cell migration is yet to be addressed. To examine these concepts in an experimentally and genetically tractable system we have used the single celled amoeba Dictyostelium discoideum. The regulation of SCAR via its regulatory complex was investigated by dissecting the Abi subunit. Abi was found to be essential for complex stability but not for its recruitment to the cell cortex or its role in pseudopod formation. The roles of WASP A were examined by generating a wasA null strain. Our results contradicted previous findings suggesting that WASP A was essential for pseudopod formation and instead demonstrated that WASP A was required for clathrin-mediated endocytosis. Unexpectedly, WASP A – driven clathrin-mediated endocytosis was found to be necessary for efficient uropod retraction during cell migration and furrowing during cytokinesis. Finally, we created a double scrA/wasA mutant, and found that it was unable to generate pseudopodia. Therefore, we were able to confirm that SCAR is the predominant driver of pseudopod formation in wild-type Dictyostelium cells, and that only WASP A can assume its role in the scrA null. Surprisingly, the double mutant was also deficient in bleb formation, showing that these proteins are also necessary for this alternative, Arp2/3 complex-independent mode of motility. This implies that there exists interplay between the different types of actin-based protrusions and the molecular pathways that underlie their formation.

Published
2014

89. Work-Efficient Parallel GPU Methods for Single-Source Shortest Paths

Author

Davidson, Andrew Alan, Baxter, Sean, Garland, Michael, and Owens, John D

Subjects
GPU Computing, graph traversal, single-source shortest paths, sparse graphs
Abstract

Finding the shortest paths from a single source to all other vertices is a fundamental method used in a variety of higher-level graph algorithms. We present three parallel friendly and work-efficient methods to solve this Single-Source Shortest Paths (SSSP) problem: Workfront Sweep, Near-Far and Bucketing. These methods choose different approaches to balance the tradeoff between saving work and organizational overhead. In practice, all of these methods do much less work than traditional Bellman-Ford methods, while adding only a modest amount of extra work over serial methods. These methods are designed to have a sufficient parallel workload to fill modern massively-parallel machines, and select reorganizational schemes that map well to these architectures. We show that in general our Near-Far method has the highest performance on modern GPUs, outperforming other parallel methods.We also explore a variety of parallel load-balanced graph traversal strategies and apply them towards our SSSP solver. Our work-saving methods always outperform a traditional GPU Bellman-Ford implementation, achieving rates up to 14x higher on low-degree graphs and 340x higher on scalefree graphs. We also see significant speedups (20–60x) when compared against a serial implementation on graphs with adequately high degree.

Published
2014

90. k-d Darts

Author

Ebeida, Mohamed S, Patney, Anjul, Mitchell, Scott A, Dalbey, Keith R, Davidson, Andrew A, and Owens, John D

Subjects
Algorithms, Theory, Sampling, dimension, line search, thin regions, rendering, depth-of-field, Poisson-disk sampling, Monte Carlo integration, Latin hypercube sampling, uncertainty quantification, cs.GR, I.3.5, Artificial Intelligence and Image Processing, Information Systems, Software Engineering
Abstract

In this work, we introduced k-d darts as a particular type of higherdimensional sampling. We described a k-d dart framework for hyperplanes of general dimension k, and then demonstrated efficiency and accuracy over three applications using k = 1, and accuracy for one application using k = 1. In particular, darts produce accurate estimates of the volume of an object regardless of the dimension, orientation, and aspect ratio of the object. Axis-aligned darts are universally preferable to unaligned ones for sampling square domains, and we expect this to extend to hyperrectangles, such as bounding boxes. Darts also produce accurate mean estimates for function integration. © 2014 ACM 0730-0301/2014/01-ART3 15.00.

Published
2014

91. Pain in children with Bell's palsy: secondary analysis of a randomised controlled trial.

Author

Babl, Franz E., Eapen, Nitaa, Herd, David, Borland, Meredith L., Kochar, Amit, Lawton, Ben, Hort, Jason, West, Adam, George, Shane, Davidson, Andrew, Cheek, John A., Oakley, Ed, Hopper, Sandy M., Berkowitz, Robert G., Wilson, Catherine L., Williams, Amanda, MacKay, Mark T., Lee, Katherine J., Hearps, Stephen, and Dalziel, Stuart R.

Subjects
BELL'S palsy, FACIAL paralysis, RANDOMIZED controlled trials, SECONDARY analysis, LATENT tuberculosis, JUVENILE idiopathic arthritis
Abstract

This article provides a secondary analysis of a clinical trial on children with Bell's palsy, focusing on the prevalence and severity of pain in these patients. The study found that pain is not common in children with Bell's palsy and is more likely to occur early in the disease and in severe cases. The intensity of pain, if present, is generally low throughout the course of the illness. It is important for clinicians to assess for pain at the initial presentation and reassure patients and parents that it is unlikely to persist. However, persistent or high levels of pain may warrant consideration of alternative diagnoses. It is worth noting that the study did not include children with vesicles or possible Ramsay Hunt syndrome, so the findings may not apply to those conditions. [Extracted from the article]

Published
2024
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92. Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling.

Author

Algera, Russell F., Davidson, Andrew, Herbert, David K., Lian, Yajing, Liu, Fangfang, Liu, Yiyang, Nematalla, Asaad, Piper, Jared L., Magano, Javier, Monfette, Sebastien, Nguyen, Bao, Raggon, Jeffrey W., Rainville, Joseph P., Rane, Anil, Tao, Yong, Wang, Ke, and Yayla, Hatice G.

Subjects
*PULMONARY arterial hypertension, *VASCULAR remodeling
Abstract

This article discusses the development of a clinical compound, PF-06842874, for the treatment of Pulmonary Arterial Hypertension (PAH). The authors focus on the synthesis of the compound and the challenges faced in the process, such as low purity and the use of undesirable solvents. They explore different coupling methods and identify a Pd-catalyzed Buchwald-Hartwig coupling as the most effective approach. The article provides valuable insights into the development of a potential treatment for PAH and describes a robust and scalable process for the synthesis of the compound. [Extracted from the article]

Published
2024
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93. Providing Australian children and adolescents with equitable access to new and emerging therapies through clinical trials: a call to action.

Author

Lorentzos, Michelle S, Metz, David, Moore, Andrew S, Fawcett, Laura K, Bray, Paula, Attwood, Lani, Munns, Craig F, and Davidson, Andrew

Abstract

This article discusses the importance of increasing access to new therapies for Australian children and adolescents through clinical trials. It emphasizes the need for investment and a coordinated national approach to ensure that Australian children do not fall behind their international peers. The article highlights the benefits of collaborative approaches and strategic investment in pediatric clinical trials, as well as the challenges in delivering high-quality trials in this population. It acknowledges the additional challenges faced in Australia due to distance and regulatory factors, and calls for equitable access to emerging treatments for all Australian children, regardless of their circumstances. The article concludes by emphasizing the need for national investment in pediatric clinical trial delivery in Australia. [Extracted from the article]

Published
2024
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94. Warming and top‐down control of stage‐structured prey: Linking theory to patterns in natural systems.

Author

Davidson, Andrew T., Stunkle, C. Ryland, Armstrong, Joshua T., Hamman, Elizabeth A., McCoy, Michael W., and Vonesh, James R.

Subjects
*PREDATION, *PREDATOR management, *DRAGONFLIES, *AQUATIC ecology, *PREY availability, *MINERAL collecting, *MOSQUITO control, *AEDES aegypti
Abstract

Warming has broad and often nonlinear impacts on organismal physiology and traits, allowing it to impact species interactions like predation through a variety of pathways that may be difficult to predict. Predictions are commonly based on short‐term experiments and models, and these studies often yield conflicting results depending on the environmental context, spatiotemporal scale, and the predator and prey species considered. Thus, the accuracy of predicted changes in interaction strength, and their importance to the broader ecosystems they take place in, remain unclear. Here, we attempted to link one such set of predictions generated using theory, modeling, and controlled experiments to patterns in the natural abundance of prey across a broad thermal gradient. To do so, we first predicted how warming would impact a stage‐structured predator–prey interaction in riverine rock pools between Pantala spp. dragonfly nymph predators and Aedes atropalpus mosquito larval prey. We then described temperature variation across a set of hundreds of riverine rock pools (n = 775) and leveraged this natural gradient to look for evidence for or against our model's predictions. Our model's predictions suggested that warming should weaken predator control of mosquito larval prey by accelerating their development and shrinking the window of time during which aquatic dragonfly nymphs could consume them. This was consistent with data collected in rock pool ecosystems, where the negative effects of dragonfly nymph predators on mosquito larval abundance were weaker in warmer pools. Our findings provide additional evidence to substantiate our model‐derived predictions while emphasizing the importance of assessing similar predictions using natural gradients of temperature whenever possible. [ABSTRACT FROM AUTHOR]

Published
2024
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95. Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling

Author

Liu, Yiyang, primary, Monfette, Sebastien, primary, Algera, Russell F., additional, Davidson, Andrew, additional, Herbert, David K., additional, Lian, Yajing, additional, Liu, Fangfang, additional, Nematalla, Asaad, additional, Piper, Jared L., additional, Magano, Javier, additional, Nguyen, Bao, additional, Raggon, Jeffrey W., additional, Rainville, Joseph P., additional, Rane, Anil, additional, Tao, Yong, additional, Wang, Ke, additional, and Yayla, Hatice G., additional

Published
2023
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100. Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated in vivo

Author

Gu, Shichun, primary, Bentley, Eleanor G, additional, Milligan, Rachel I, additional, Almuqrin, Abdulaziz M, additional, Sharma, Parul, additional, Kirby, Adam, additional, Mega, Daniele F, additional, Kipar, Anja, additional, Erdmann, Max, additional, Bazire, James, additional, Heesom, Kate J, additional, Lewis, Phillip A, additional, Donovan-Banfield, I'ah, additional, Reston, Charlotte, additional, Webb, Isobel, additional, de Neck, Simon, additional, Dong, Xiaofeng, additional, Hiscox, Julian Alexander, additional, Davidson, Andrew D, additional, Stewart, James P, additional, and Matthews, David A, additional

Published
2023
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