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Understanding the relationship between urban fabrics and sustainability is essential for addressing contemporary urban challenges, as urban fabrics provide critical morphological and socio-economic data that enhance our understanding of the performance and spatial variability of urban systems. This study focuses on Cuenca, spatially divided into a 150 m radius hexagonal grid with 30 sustainability indicators and 18 urban fabric typologies. Using spatial, statistical, and visual analysis, relationships and patterns between sustainability indicators and urban fabric types are explored. The results reveal significant variation in sustainability across different fabric types, with built environment indicators playing a central role. There is marked spatial heterogeneity: inner-core areas exhibit higher sustainability, fringe areas lag behind, and transitional zones are also identified. Spatial clustering reveals that fabric types are homogeneous in terms of sustainability at both the high and low extremes but heterogeneous in mid-range sustainability areas. This quantitative analysis of Cuenca's urban fabric typologies highlights substantial differences in sustainability and distinct spatial patterns, offering valuable insights for evidence-based urban planning. The open-source data and tools provided facilitate customisation and replication in other urban contexts. [ABSTRACT FROM AUTHOR]

Active mobility to school (AMS) has been identified as a pivotal element in promoting health and physical activity during childhood, adolescence, and beyond. However, the importance of AMS is often downplayed or disregarded in urban and transportation planning, especially in Latin American cities. Factors such as cultural and political dynamics, socioeconomic conditions, urban and social environments, household and individual characteristics, and parental perceptions and attitudes collectively shape the mobility behavior of schoolchildren. This research analyzes the outcomes of a study on AMS at public schools in Cuenca and Ibarra (Ecuador), through the lens of the Socio-Ecological Model framework. The findings show that 47% of students from schools in Cuenca and 26% from Ibarra engage in active commuting to school for at least part of their journey. Key factors correlated with AMS include gender (individual dimension), travel duration, household socioeconomic characteristics, and parental attitudes towards active mobility (household dimension), as well as street-level attributes and land use density surrounding schools (urban environment dimension). This study offers three significant contributions: a detailed portrayal of student mobility behavior at six public schools in Cuenca and Ibarra, an exploration of the factors linked with active commuting, and a methodology for estimating land-use parameters. [ABSTRACT FROM AUTHOR]

As cities and economies grow, energy demands also grow, especially in developing countries, given the material production, construction, and operational processes of buildings and cities. Since the recent Powerhouse standard assumes that a building can generate as much energy as it will require during its lifespan, the present study aimed to implement this building standard in the Andean equatorial climate. For this purpose, a building energy model (BEM) integrated into a building information modeling (BIM) process design method was proposed, developing a prototype with vernacular technology, high solar potential, and local or regional data on embodied energy in accordance with a life cycle assessment (LCA) from cradle to grave. Solar potential estimations were complemented by system advisor model (SAM) tool projections. Because of the low energy content of the vernacular architecture proposal and prototype development with a high generation capacity, this standard can be met six times faster in the Andean equatorial climate than in extreme seasonal climates (8.53 years versus 60.0 years). The main goal of our research was to propose a methodological approach that integrates the BEM tool with vernacular concepts and materials and architectural formal criteria for high solar exploitation that, with background data from the literature, makes it possible to decipher the capability of the proposed energy standard. [ABSTRACT FROM AUTHOR]

This article presents the case of Guatemalan Pentecostalism as a highly relevant expression of Latin American Pentecostalism that helps to clarify the debate about the syncretic nature of Pentecostalism. We use the Guatemalan case to test the thesis of Juan Sepúlveda, a Chilean Pentecostal historian and theologian, who explains the success of Latin American Pentecostalism in light of its syncretic character. His argument about the syncretic character of Pentecostalism is based on the Chilean case. Paying attention to its historical development, we present Guatemalan Pentecostal theology in relation to traditional Mayan culture and religion and in relation to popular Catholicism and traditional Latin American Protestantism. Specific attention is paid to the espoused theology of Pentecostal pastors as they provide an account of indigenous Pentecostals' lived faith. Finally, we answer the question: Does Juan Sepulveda's approach (still) provide an adequate framework for the theological assessment of possible syncretic characteristics of (Latin American) Pentecostalism? The Guatemalan case indicates ways to improve certain limitations of Sepúlveda's approach, such as its static understanding of culture and its exclusion of the theological understanding of syncretism. [ABSTRACT FROM AUTHOR]

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Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in the mouse brain, while attenuation of ERK signaling does the opposite. This neuroprotective effect mediated by an enhanced nuclear ERK activity can also be induced by the novel cell penetrating peptide RB5. In vitro administration of RB5 disrupts the preferential interaction of ERK1 MAP kinase with importinα1/KPNA2 over ERK2, facilitates ERK1/2 nuclear translocation, and enhances global ERK activity. Importantly, RB5 treatment in vivo promotes neuroprotection in mouse models of Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) disease, and enhances ERK signaling in a human cellular model of HD. Additionally, RB5‐mediated potentiation of ERK nuclear signaling facilitates synaptic plasticity, enhances cognition in healthy rodents, and rescues cognitive impairments in AD and HD models. The reported molecular mechanism shared across multiple neurodegenerative disorders reveals a potential new therapeutic target approach based on the modulation of KPNA2‐ERK1/2 interactions. Synopsis: Shared mechanisms governing both neuronal cell survival and neuroplasticity have not yet been explored therapeutically. This study demonstrates that modulation of ERK1 and KPNA2 interactions strengthens nuclear ERK signaling in the brain, promotes cognitive enhancement, and delays neurodegeneration. Genetic approaches altering ERK1 and ERK2 MAP kinase ratio, enhance global ERK signaling and attenuate neuronal cell death in vitro and in vivo.A cell penetrating peptide (RB5), designed around the unique N‐terminal domain of ERK1 MAP kinase, enhances nuclear ERK signaling in cells and in the mouse brain by mimicking ERK1 downregulation.RB5 prevents ERK1 interactions with the nuclear importin alpha KPNA2 and facilitates nuclear entry of the main Kinase ERK2.RB5 prevents synaptic dysfunction and neuronal cell death in mouse models of Huntington's, Alzheimer's and Parkinson's Disease.RB5 enhances memory formation and consolidation and facilitates synaptic plasticity in normal mice and models of neurodegeneration. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has affected Bangladesh's economic and social well-being in many ways. Slum dwellers, including day laborers, rickshaw pullers, CNG (Compressed Natural Gas) drivers, housemaids, hawkers, and street vendors, were the worst victims of this pandemic. Besides the voluntary organizations, the City Corporation (urban local government), instructed by the central government, took the initiative to distribute necessary food as well as financial assistance to the city dwellers to survive during the lockdown. The objective of this study is to identify the satisfaction level of slum dwellers with the assistance received from the City Corporation and obtain an idea of whether these supports were enough for them to maintain their livelihood. This is a mixed method research consisting of both qualitative and quantitative approaches. Researchers conducted a field survey in Sylhet City Corporation, in the northeastern part of Bangladesh, and collected primary data from one hundred and fifty-five respondents through a structured questionnaire along with an interview (semi-structured) schedule. Samples were selected by applying a multistage sampling technique. Researchers analyzed quantitative data using SPSS software and qualitative data using the thematic analysis method. Study findings reveal that nepotism, patron–client relation, corruption, unequal treatment, management flaws, low level of community engagement, political consideration, and lack of monitoring were the major issues in providing effective service delivery to slum dwellers during COVID-19. Citizen participation, well coordination, proper monitoring, impersonality, and good governance are indispensable for dealing with any crisis. [ABSTRACT FROM AUTHOR]

Copyright of Environment, Development & Sustainability is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cuadernos de Geografia: Revista Colombiana de Geografía is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article presents a study which proposed a statistical approach for the detection of patterns of movement suspension. The approach uses a local indicator of spatial association (LISA) in a representation of vector space. Positioning data sets used to evaluate the statistical approach are discussed, including visitors of a natural park and players of an urban outdoor mobile game. It is concluded that LISA is a reliable approach for movement suspension pattern exploration.

The article presents results from Ecuador's 2018 Report Card on Physical Activity for Children and Youth. It mentions indicators on the basis of which grades are assigned including organized sport participation, active transportation, and sedentary behavior. The report card reveals that Ecuadorian children and adolescents are insufficiently active, therefore, preventive strategies are urgently needed to promote physical activity as well as to prevent sedentary behaviors among children.

In routine clinical practice, hepatitis C virus‐infected patients can prematurely discontinue the prescribed regimen for several reasons. The aim of our study was to investigate sustained virological response (SVR12) rates in patients who prematurely discontinued directly acting antiviral (DAA) regimens and to assess the shortest effective duration of DAA able to lead to SVR12. We retrospectively collected the SVR rates of patients, registered in the NAVIGATORE‐Lombardia Network database from January 2015, who discontinued DAAs before the predefined end of treatment. Overall, we included 365 patients, males were the majority (213, 58.4%), mean age was 60.5 years, and 53 (14.5%) patients were HIV‐co‐infected. Liver cirrhosis was observed in 251 (68.8%) subjects, and the most represented genotypes were 1b (n = 168, 46%) and 3 (n = 59, 16.2%). DAA was discontinued a median of 1 (IQR 1–4) weeks before the predefined EOT, with 164 (44.9%) patients stopping DAAs at least 2 weeks before the planned schedule. In patients with F0–F3 liver fibrosis, lower rates of SVR12 were observed in patients treated for <4 weeks: 50% (n = 2/4) vs. 99.1% (n = 109/110) for ≥4 weeks, p = 0.003. In patients with liver cirrhosis, lower rates of SVR12 were observed in patients treated <8 weeks: 83.3% (n = 25/30) vs. 94.6% (n = 209/221) for ≥8 weeks, p = 0.038. Despite premature discontinuation of DAA, high SVR12 rates were observed in a real‐life setting for treatment lasting at least 4 weeks in patients with liver fibrosis F0–F3 and 8 weeks in those with liver cirrhosis. On this basis, feasibility of reducing DAA treatment duration should be explored in randomized clinical trials. [ABSTRACT FROM AUTHOR]

To reduce and prevent significant economic flood losses, reliable tools are required to estimate potential river inundation effects. This paper focuses on the estimation of direct damages caused by flooding with different return periods in urban and agricultural areas. A univariable deterministic flood loss model was developed to estimate potential damages, based on water depth. This approach involved assessing the mapping of local flood risks based on the combination of historical inundation marks, land-use and economic data. The primary objective of this study is to determine whether it is possible to use accessible data at the municipality level to assess economic flood losses. For the Santa Bárbara River case study, the results reveal that the greatest proportion of damages (approximately 99%) is expected to occur in the urban area. In addition, results showed that the approach is useful for identifying and mapping flooded areas with critical damage. The proposed methodology can be applied to microscale analysis, thereby providing quantitative results for flood risk assessment, the outcomes of which could assist local decision-makers in the prioritization of critical risk areas, and the development of mitigation options and countermeasures. As such, this is the first study to propose and provide an open-access methodology for quantifying flood losses in the inter-Andean region of Ecuador. [ABSTRACT FROM AUTHOR]

Climate teleconnections show remote and large-scale relationships between distant points on Earth. Their relations to precipitation are important to monitor and anticipate the anomalies that they can produce in the local climate, such as flood and drought events impacting agriculture, health, and hydropower generation. Climate teleconnections in relation to precipitation have been widely studied. Nevertheless, the spatial association of the teleconnection patterns (i.e. the spatial delineation of regions with teleconnections) has been unattended. Such spatial association allows to characterize how stable (heterogeneity/dependent and statistically significant) is the underlying spatial phenomena for a given pattern. Thus our objective was to characterize the spatial association of climate teleconnection patterns related to precipitation using an exploratory spatial data analysis approach. Global and local indicators of spatial association (Moran's I and LISA) were used to detect spatial patterns of teleconnections based on TRMM satellite images and climate indices. Moran's I depicted high positive spatial association for different climate indices, and LISA depicted two types of teleconnections patterns. The homogenous patterns were localized in the Coast and Amazonian regions, meanwhile the disperse patterns had a major presence in the Highlands. The results also showed some areas that, although with moderate to high teleconnection influences, had a random spatial patterns (i.e. non-significant spatial association). Other areas showed both teleconnections and significant spatial association, but with dispersed patterns. This pointed out the need to explore the local underlying features (topography, orientation, wind and micro-climates) that restrict (non-significant spatial association) or reaffirm (disperse patterns) the teleconnection patterns. [ABSTRACT FROM AUTHOR]

This study explores the potential influence of the urban built environment on pedestrian flow in an intermediate Latin American city, Cuenca-Ecuador. Data from samples of 48 street segments were analyzed to explore how physical and spatial features of streets and sidewalks, as well as land use and occupation conditions influence the number of pedestrians. A quantitative approach was used to model the individual and combined influences of several variables on pedestrian counts using multiple regression models. Results from statistical modeling indicate that variables related to the physical features of the streets, such as sidewalk width, are positively correlated to pedestrian counts, whereas parking space and front setback are negatively correlated. We conclude that streets in our study area are largely inadequate for pedestrians due to their poor design, scarce walking infrastructure, and the prevalence of all sorts of obstacles on the sidewalks. Pedestrians, however, seem to cope with this adverse environment by adopting different strategies. We expect that this study will help city planners design better environments for non-motorized travel in intermediate cities. [ABSTRACT FROM AUTHOR]

Acute myeloid leukemia (AML) is the most common form of adult acute leukemia with ~20,000 new cases yearly. The disease develops in people of all ages, but is more prominent in the elderly, who due to limited treatment options, have poor overall survival rates. Monoclonal antibodies (mAb) targeting specific cell surface molecules have proven to be safe and effective in different haematological malignancies. However, AML target molecules are currently limited so discovery of new targets would be highly beneficial to patients. We examined the C-type lectin receptor CD302 as a potential therapeutic target for AML due to its selective expression in myeloid immune populations. In a cohort of 33 AML patients with varied morphological and karyotypic classifications, 88% were found to express CD302 on the surface of blasts and 80% on the surface of CD34+ CD38- population enriched with leukemic stem cells. A mAb targeting human CD302 was effective in mediating antibody dependent cell cytotoxicity and was internalised, making it amenable to toxin conjugation. Targeting CD302 with antibody limited in vivo engraftment of the leukemic cell line HL-60 in NOD/SCID mice. While CD302 was expressed in a hepatic cell line, HepG2, this molecule was not detected on the surface of HepG2, nor could HepG2 be killed using a CD302 antibody-drug conjugate. Expression was however found on the surface of haematopoietic stem cells suggesting that targeting CD302 would be most effective prior to haematopoietic transplantation. These studies provide the foundation for examining CD302 as a potential therapeutic target for AML. [ABSTRACT FROM AUTHOR]

The dedicated effort of conscientious and expert referees is central to the publication of high-value and impactful research for the benefit of academic as well as industrial readership of the journal. The Editorial Board and Editors of I Drying Technology i gratefully acknowledge the assistance of the following panel of referees from around the world as peer reviewers for archival publication in this journal. [Extracted from the article]

Copyright of Protestantismo em Revista is the property of Nucleo de Estudos e Pesquisa do Protestantismo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The Galapagos Archipelago is one of the most important ecological spots in the planet due its unique biodiversity, active geology, and relatively well-preserved ecosystems. These characteristics are strongly based on the geographical isolation of the islands. On the one hand this isolation allowed the evolution processes that gave the islands their international fame and on the other hand it kept them from major human impacts that affected the vast majority of the Earth's surface. Galapagos' geographical isolation is therefore of mayor value, but it is rapidly diminishing due to the increase of marine and air transportation among islands and with the rest of the world. This increased accessibility implies enhanced risks for the ecological dynamics on the archipelago (e.g. increased risk of biological invasions, uncontrolled tourism growth, more water and energy consumption). Here, we introduce a general accessibility model to assess geographical isolation of the Galapagos Islands. The model aims to characterize accessibility in terms of human mobility by evaluating travel time to each point of the archipelago using all available transportation modalities. Using a multi criteria cost surface for marine and land areas, we estimated travel time for each surface unit using the fastest route and mode of transportation available while considering several friction factors such as surface type, slope, infrastructure, transfer points, legal restrictions, and physical barriers. We created maps to evaluate the isolation of different islands and places, highlighting the potential risks for several habitats and ecosystems. The model can be used for research and decision-making regarding island conservation, such as estimating spreading paths for invasive species, informing decisions on tourism management, and monitoring isolation changes of sensitive ecosystems. [ABSTRACT FROM AUTHOR]

Intermediate cities are urged to change and adapt their mobility systems from a high energy-demanding motorized model to a sustainable low-motorized model. In order to accomplish such a model, city administrations need to better understand active mobility patterns and their links to socio-demographic and cultural aspects of the population. During the last decade, researchers have demonstrated the potential of geo-location technologies and mobile devices to gather massive amounts of data for mobility studies. However, the analysis and interpretation of this data has been carried out by specialized research groups with relatively narrow approaches from different disciplines. Consequently, broader questions remain less explored, mainly those relating to spatial behaviour of individuals and populations with their geographic environment and the motivations and perceptions shaping such behaviour. Understanding sustainable mobility and exploring new research paths require an interdisciplinary approach given the complex nature of mobility systems and their social, economic and environmental impacts. Here, we introduce the elements for a multidisciplinary analytical framework for studying active mobility patterns comprised of three components: a) Methodological, b) Behavioural, and c) Perceptual. We demonstrate the applicability of the framework by analysing mobility patterns of cyclists and pedestrians in an intermediate city integrating a range of techniques, including: GPS tracking, spatial analysis, auto-ethnography, and perceptual mapping. The results demonstrated the existence of non-evident spatial behaviours and how perceptual features affect mobility. This knowledge is useful for developing policies and practices for sustainable mobility planning. [ABSTRACT FROM AUTHOR]

In the Galapagos Islands, where 97% of the territory is protected and ecosystem dynamics are highly vulnerable, timely and accurate information is key for decision making. An appropriate monitoring system must meet two key features: on one hand, being able to capture information in a systematic and regular basis, and on the other hand, to quickly gather information on demand for specific purposes. The lack of such a system for geographic information limits the ability of Galapagos Islands' institutions to evaluate and act upon environmental threats such as invasive species spread and vegetation degradation. In this context, the use of UAVs (unmanned aerial vehicles) for capturing georeferenced images is a promising technology for environmental monitoring and management. This paper explores the potential of UAV images for monitoring degradation of littoral vegetation in Puerto Villamil (Isabela Island, Galapagos, Ecuador). Imagery was captured using two camera types: Red Green Blue (RGB) and Infrarred Red Green (NIR). First, vegetation presence was identified through NDVI. Second, object-based classification was carried out for characterization of vegetation vigor. Results demonstrates the feasibility of UAV technology for base-line studies and monitoring on the amount and vigorousness of littoral vegetation in the Galapagos Islands. It is also showed that UAV images are not only useful for visual interpretation and object delineation, but also to timely produce useful thematic information for environmental management. [ABSTRACT FROM AUTHOR]

The role of religion in Latin American politics can no longer be interpreted with reductionist schemes. The faithful—citizens—are combining faith and politics in unprecedented ways, and churches and denominations are no longer factors of political identity. The reconfiguration of new social and political movements interweaves complex linkages with the religious. The transformations of the political field and especially of democratic processes have reshaped identities in a context of increasing religious and cultural diversity with relatively less Catholic presence and greater Evangelical presence. Institutional secularization and religious pluralism seem to go hand in hand with a new cleavage between religion and politics.La presencia de lo religioso en el campo político latinoamericano ya no puede ser interpretada con esquemas reduccionistas. Los fieles—ciudadanos—entremezclan fe y política de maneras inéditas, y las iglesias y denominaciones ya no son factor de identidad política. La re-configuración de los nuevos movimientos sociales y políticos entretejen vinculaciones complejas con lo religioso. Las transformaciones del campo político y en especial de los procesos democráticos han redefinido las identidades en un contexto de diversidad religiosa y cultural creciente con menor presencia relativa católica y mayor presencia evangélica. Secularización institucional y garantía del pluralismo religioso parecen ir de la mano con un nuevo clivaje entre religión y política. [ABSTRACT FROM AUTHOR]

Copyright of Analítika: Journal of Statistical Analysis / Revista de Análisis Estadístico is the property of Analitika: Journal of Statistical Analysis / Revista de Analisis Estadistico and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

People who the author would like to thank for their assistance in the creation of the "Geographical Analysis" are mentioned, including Michael Barber, Naresh Kumar, and George Petrakos.