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51. Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study

Author: Navarrete-Muñoz, Eva-Maria, Vioque, Jesus, Toledo, Estefanía, Oncina-Canovas, Alejando, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Matía-Martín, Pilar, Daimiel, Lidia, Sánchez, Vicente Martín, Vidal, Josep, de Cos Blanco, Ana Isabel, Ros, Emili, Diez-Espino, Javier, Babio, Nancy, Fernandez-Carrion, Rebeca, Castañer, Olga, Colom, Antoni, Compañ-Gabucio, Laura, Lete, Itziar Salaverria, Crespo-Oliva, Edelys, Abete, Itziar, Tomaino, Laura, Casas, Rosa, Fernandez-Garcia, José Carlos, Santos-Lozano, José Manuel, Sarasa, Iziar, Gámez, José M., Garcia-Rios, José M. Antonio, Martín-Pelaez, Sandra, Ruiz-Canela, Miguel, Díaz-López, Andrés, Martinez-Lacruz, Raul, Zomeño, Maria Dolors, Rayó, Elena, Sellés, Cristina Gisbert, Canudas, Silvia, Goday, Albert, and García-de-la-Hera, Manoli
Published: 2021
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52. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health

Author: Domínguez‐López, Inés, primary, Galkina, Polina, additional, Parilli‐Moser, Isabella, additional, Arancibia‐Riveros, Camila, additional, Martínez‐González, Miguel Ángel, additional, Salas‐Salvadó, Jordi, additional, Corella, Dolores, additional, Malcampo, Mireia, additional, Martínez, J. Alfredo, additional, Tojal‐Sierra, Lucas, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López‐Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos‐Lozano, José Manuel, additional, Serra‐Majem, Lluís, additional, Bueno‐Cavanillas, Aurora, additional, Tur, Josep A., additional, Rubín‐García, María, additional, Pintó, Xavier, additional, Fernández‐Aranda, Fernando, additional, Delgado‐Rodríguez, Miguel, additional, Barabash‐Bustelo, Ana, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Toledo, Estefania, additional, Atzeni, Alessandro, additional, Asensio, Eva M., additional, Vera, Natàlia, additional, Garcia‐Rios, Antonio, additional, Torres‐Collado, Laura, additional, Pérez‐Farinós, Napoleón, additional, Zulet, Marian, additional, Chaplin, Alice, additional, Casas, Rosa, additional, Martín‐Peláez, Sandra, additional, Vaquero‐Luna, Jessica, additional, Gómez‐Pérez, Ana Maria, additional, Vázquez‐Ruiz, Zenaida, additional, Shyam, Sangeetha, additional, Ortega‐Azorín, Carolina, additional, Talens, Natàlia, additional, Peña‐Orihuela, Patricia J., additional, Oncina‐Canovas, Alejandro, additional, Diez‐Espino, Javier, additional, Babio, Nancy, additional, Fitó, Montserrat, additional, and Lamuela‐Raventós, Rosa M., additional
Published: 2023
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53. Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk

Author: Donat-Vargas, Carolina, primary, Mico, Víctor, additional, San-Cristobal, Rodrigo, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Alonso-Gómez, Ángel Maria, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Damas-Fuentes, Miguel, additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep Antoni, additional, Cinza-Sanjurjo, Sergio, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Causso, Claudia, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Manzanares, Josep Maria, additional, Ortega-Azorín, Carolina, additional, Castañer, Olga, additional, Peña-Orihuela, Patricia Judith, additional, Zazo, Juan Manuel, additional, Muñoz Bravo, Carlos, additional, Martinez-Urbistondo, Diego, additional, Chaplin, Alice, additional, Casas, Rosa, additional, Cano Ibáñez, Naomi, additional, Tojal-Sierra, Lucas, additional, Gómez-Perez, Ana María, additional, Pascual Roquet-Jalmar, Elena, additional, Mestre, Cristina, additional, Barragán, Rocío, additional, Schröder, Helmut, additional, Garcia-Rios, Antonio, additional, Candela García, Inmaculada, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Malcampo, Mireia, additional, Daimiel, Lidia, additional, and Martínez, Alfredo, additional
Published: 2023
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54. Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome

Author: Shyam, Sangeetha, primary, Gómez-Martínez, Carlos, additional, Paz-Graniel, Indira, additional, Gaforio, José J., additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Ortiz Ramos, María, additional, Vidal, Josep, additional, Mar Alcarria, Maria, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Fernandez-Aranda, Fernando, additional, Nishi, Stephanie K., additional, García Regata, Oscar, additional, Toledo, Estefania, additional, Sorli, Jose V., additional, Castañer, Olga, additional, Garcia-Rios, Antonio, additional, Valls-Enguix, Rafael, additional, Perez-Farinos, Napoleon, additional, Zulet, M. Angeles, additional, Rayó-Gago, Elena, additional, Casas, Rosa, additional, Rivera-Izquierdo, Mario, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Buil-Cosiales, Pilar, additional, Fernández-Carrion, Rebeca, additional, Goday, Albert, additional, Peña-Orihuela, Patricia J., additional, Compañ-Gabucio, Laura, additional, Diez-Espino, Javier, additional, Tello, Susanna, additional, González-Pinto, Ana, additional, de la O, Víctor, additional, Delgado-Rodríguez, Miguel, additional, Babio, Nancy, additional, and Salas-Salvadó, Jordi, additional
Published: 2023
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55. Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome

Author: Rognoni, Teresa, primary, Fernandez-Matarrubia, Marta, additional, Martinez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Castañer, Olga, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Gómez-Gracia, Enrique, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, Lluis, additional, Cano Ibañez, Naomi, additional, Tur, Josep A., additional, Micó Pérez, Rafael, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Ortiz Ramos, María, additional, Vidal Martín, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Goñi-Ruiz, Nuria, additional, Babio, Nancy, additional, Sorlí, José V., additional, Schröder, Helmut, additional, García-Rios, Antonio, additional, Compañ-Gabucio, Laura, additional, Warnberg, Julia, additional, Zulet, M. Ángeles, additional, Chaplin, Alice, additional, Sacanella, Emilio, additional, Bouzalmate-Hajjaj, Amira, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Vázquez, Zenaida, additional, Gómez-Martínez, Carlos, additional, Saiz, Carmen, additional, Malcampo, Mireia, additional, Ortiz-Morales, Ana M., additional, Martínez-Avilés, Vanessa, additional, García-Gavilan, Jesús, additional, Abete, Itziar, additional, Fitó, Montserrat, additional, and Toledo, Estefanía, additional
Published: 2023
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56. Association of monetary diet cost of foods and diet quality in Spanish older adults

Author: Bouzas, Cristina, primary, Pastor, Rosario, additional, García, Silvia, additional, Monserrat-Mesquida, Margalida, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Lopez-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Riquelme-Gallego, Blanca, additional, Romero-Secin, Anny, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía, Pilar, additional, Vidal, Josep, additional, Zapatero, Miriam, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, García-Arellano, Ana, additional, Babio, Nancy, additional, Gonzalez-Monje, Inmaculada, additional, Castañer, Olga, additional, Abete, Itziar, additional, Tojal-Sierra, Lucas, additional, Benavente-Marín, Juan Carlos, additional, Signes-Pastor, Antonio, additional, Konieczna, Jadwiga, additional, García-Ríos, Antonio, additional, Castro-Barquero, Sara, additional, Fernández-García, José C., additional, Santos-Lozano, José Manuel, additional, Bes-Rastrollo, Maira, additional, Mestres, Cristina, additional, Guillem-Saiz, Patricia, additional, Goday, Albert, additional, Goicolea-Güemez, Leire, additional, Puig-Aguiló, Estanislao, additional, Ruiz-Canela, Miguel, additional, Palau-Galindo, Antoni, additional, Fitó, Montse, additional, and Tur, Josep A., additional
Published: 2023
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57. How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?

Author: Paz-Graniel, Indira, primary, Babio, Nancy, additional, Nishi, Stephanie K., additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Santos-Lozano, José Manuel, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Sánchez, Vicente Martín, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Calderon-Sanchez, Cristina, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Fernández-Aranda, Fernando, additional, Toledo, Estefania, additional, Valle-Hita, Cristina, additional, Sorli, Jose V., additional, Lassale, Camille, additional, Garcia-Rios, Antonio, additional, Oncina-Canovas, Alejandro, additional, Barón-López, Francisco Javier, additional, Zulet, M. Angeles, additional, Rayó, Elena, additional, Casas, Rosa, additional, Thomas-Carazo, Esther, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Ruiz-Canela, Miguel, additional, De las Heras-Delgado, Sara, additional, Fernandez-Carrión, Rebeca, additional, Castañer, Olga, additional, Peña-Orihuela, Patricia J., additional, Gonzalez-Palacios, Sandra, additional, Buil-Cosiales, Pilar, additional, Goday, Albert, additional, and Salas-Salvadó, Jordi, additional
Published: 2023
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58. PTFS07-01-23 Weight Loss, Based on an Energy-Reduced Mediterranean Diet Plus Physical Activity Intervention, Impacts on Immunosenescence and HDL Functionality

Author: Daimiel, Lidia, primary, Castañer, Olga, additional, Cuadrado-Soto, Esther, additional, Díez-Ricote, Laura, additional, de la Peña Martín, Gema, additional, Marcos, Pablo Fernández, additional, Gómez-Coronado, Diego, additional, Martínez, Miguel, additional, Martínez-Botas, Javier, additional, Ordovás, José, additional, Fernández, Andrés Pastor, additional, and Salas-Slvadó, Jordi, additional
Published: 2023
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59. P03-013-23 Apple and Orange-Derived Extracellular Vesicles As Nanocarriers of Extracellular RNAs

Author: Davalos, Alberto, primary, de las Hazas, María-Carmen Lopez, additional, Tomé-Carneiro, Joao, additional, Del Pozo-Acebo, Lorena, additional, del Saz-Lara, Andrea, additional, Balaguer, Livia, additional, Gil-Zamorano, Judit, additional, De la Peña, Gema, additional, Chapado, Luis, additional, Crespo, Carmen, additional, Daimiel, Lidia, additional, and Ordovás, José, additional
Published: 2023
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60. Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Author: Daimiel, Lidia, Martínez-González, Miguel A., Corella, Dolores, Salas-Salvadó, Jordi, Schröder, Helmut, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, Lopez-Miranda, Jose, Estruch, Ramón, Cano-Ibáñez, Naomi, Alonso-Gómez, Angel, Tur, Josep A., Tinahones, Francisco J., Serra-Majem, Lluis, Micó-Pérez, Rafael M., Lapetra, José, Galdón, Alba, Pintó, Xavier, Vidal, Josep, Micó, Victor, Colmenarejo, Gonzalo, Gaforio, José J., Matía, Pilar, Ros, Emilio, Buil-Cosiales, Pilar, Vázquez-Ruiz, Zenaida, Sorlí, José V., Graniel, Indira Paz, Cuenca-Royo, Aida, Gisbert-Sellés, Cristina, Galmes-Panades, Aina M., Zulet, M. Angeles, García-Ríos, Antonio, Díaz-López, Andrés, de la Torre, Rafael, Galilea-Zabalza, Iñigo, and Ordovás, José M.
Published: 2020
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61. Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study

Author: Galmes-Panades, Aina M., Varela-Mato, Veronica, Konieczna, Jadwiga, Wärnberg, Julia, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Vioque, Jesús, Alonso-Gómez, Ángel M., Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Riquelme-Gallego, Blanca, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Micó Pérez, Rafael Manuel, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Garcia-Arellano, Ana, Díaz-López, Andrés, Asensio, Eva M., Castañer, Olga, Fiol, Francisca, Mira-Castejón, Luis Alfredo, Moreno Rodríguez, Anai, Benavente- Marín, Juan Carlos, Abete, Itziar, Tomaino, Laura, Casas, Rosa, Barón López, F. Javier, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Galera, Ana, Mascaró, Catalina M., Razquin, Cristina, Papandreou, Christopher, Portoles, Olga, Pérez-Vega, Karla Alejandra, Fiol, Miguel, Compañ-Gabucio, Laura, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Becerra-Tomás, Nerea, Fitó, Montserrat, and Romaguera, Dora
Published: 2019
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62. Epigenetic Biomarkers of Biological Age

Author: Daimiel, Lidia, primary and Micó, Victor, additional
Published: 2018
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63. An Interplay between Oxidative Stress (Lactate Dehydrogenase) and Inflammation (Anisocytosis) Mediates COVID-19 Severity Defined by Routine Clinical Markers

Author: Alonso-Bernáldez, Marta, primary, Cuevas-Sierra, Amanda, additional, Micó, Víctor, additional, Higuera-Gómez, Andrea, additional, Ramos-Lopez, Omar, additional, Daimiel, Lidia, additional, Dávalos, Alberto, additional, Martínez-Urbistondo, María, additional, Moreno-Torres, Víctor, additional, Ramirez de Molina, Ana, additional, Vargas, Juan Antonio, additional, and Martinez, J. Alfredo, additional
Published: 2023
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64. Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity

Author: Paz-Graniel, Indira, primary, Fitó, Montserrat, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Corella, Dolores, additional, Babio, Nancy, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluis, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Gaforio, José Juan, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, García-Gavilán, Jesus F., additional, Toledo, Estefanía, additional, Nishi, Stephanie K., additional, Sorlí, Jose V., additional, Castañer, Olga, additional, García-Ríos, Antonio, additional, García de la Hera, Manoli, additional, Barón-López, Francisco Javier, additional, Ruiz-Canela, Miguel, additional, Morey, Marga, additional, Casas, Rosa, additional, Garrido-Garrido, Eva María, additional, Tojal-Sierra, Lucas, additional, Fernández-García, José C., additional, Vázquez-Ruiz, Zenaida, additional, Fernández-Carrión, Rebeca, additional, Goday, Albert, additional, Peña-Orihuela, Patricia J., additional, Compañ-Gabucio, Laura, additional, Schröder, Helmut, additional, Martínez-Gonzalez, Miguel A., additional, and Salas-Salvadó, Jordi, additional
Published: 2023
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65. Corrigendum: Role of NAFLD on the health related QoL response to lifestyle in patients with metabolic syndrome: The PREDIMED plus cohort

Author: Martínez-Urbistondo, Diego, primary, San-Cristóbal, Rodrigo, additional, Villares, Paula, additional, Martínez-González, Miguel Ángel, additional, Babio, Nancy, additional, Corella, Dolores, additional, del Val, José Luis, additional, Ordovás, José Ma, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Marcos, Alba, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Vela, María Vanessa Bullón, additional, Palau, Antoni, additional, Sorli, Jose V., additional, Masagué, Marta, additional, Abete, Itziar, additional, Moreno-Rodríguez, Anai, additional, Candela-García, Inma, additional, Konieczna, Jadwiga, additional, García-Ríos, Antonio, additional, Juárez, Oscar Lecea, additional, Portolés, Olga, additional, Martín, Paco, additional, Goday, Albert, additional, Zulet, M. Ángeles, additional, Vaquero-Luna, Jessica, additional, Orea, María del Carmen Sayón, additional, Megías, Isabel, additional, Baltasar, Enric, additional, Martínez, J. Alfredo, additional, and Daimiel, Lidia, additional
Published: 2023
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66. Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

Author: Bullón-Vela, Vanessa, primary, Xu, Yifan, additional, Razquin, Cristina, additional, Abete, Itziar, additional, Zulet, Maria Angeles, additional, Martínez-González, Miguel A., additional, Buil-Corsiales, Pilar, additional, Vitelli-Storelli, Facundo, additional, Martín Sánchez, Vicente, additional, Vazquez-Ruíz, Zenaida, additional, Sayón-Orea, Carmen, additional, Domínguez-Fernández, Maite, additional, Cid, Concepción, additional, Estruch, Ramon, additional, Lamuela-Raventós, Rosa María, additional, Fitó, Montserrat, additional, Blanchart, Gemma, additional, Babio, Nancy, additional, Salas-Salvadó, Jordi, additional, Tinahones, Francisco J., additional, Tur, Josep A., additional, Romaguera, Dora, additional, Konieczna, Jadwiga, additional, Pintó, Xavier, additional, Daimiel, Lidia, additional, Rodriguez-Mateos, Ana, additional, and Martínez, José Alfredo, additional
Published: 2023
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67. Additional file 1 of Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study

Author: Nishi, Stephanie K., Babio, Nancy, Paz-Graniel, Indira, Serra-Majem, Lluís, Vioque, Jesús, Fitó, Montserrat, Corella, Dolores, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Diez-Ricote, Laura, Martinez, J. Alfredo, Gómez-Martínez, Carlos, González-Botella, Andrés, Castañer, Olga, Alvarez-Sala, Andrea, Montesdeoca-Mendoza, Cristina, Fanlo-Maresma, Marta, Cano-Ibáñez, Naomi, Bouzas, Cristina, Daimiel, Lidia, Zulet, María Ángeles, Sievenpiper, John L., Rodriguez, Kelly L., Vázquez-Ruiz, Zenaida, and Salas-Salvadó, Jordi
Abstract: Additional file 1: Table S1. Hydration and water intake definitions. Table S2. Associations between cognitive assessments and water and fluid intake exposures. Table S3. Associations between cognitive assessments and EFSA fluid intake related guidelines. Table S4. Associations between cognitive assessments and hydration status. Table S5. Sensitivity analysis in global cognitive function according to water and fluid intake related exposures Table S6. Sensitivity analysis in global cognitive function according to EFSA fluid intake related guidelines. Table S7. Sensitivity analysis in global cognitive function according to hydration status. Fig. S1. Flow diagram of participants. Fig. S2. Continuous sensitivity analysis by sex. Fig. S3. Categorical sensitivity analysis by sex.
Published: 2023
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68. Macrophage deficiency of miR‐21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis

Author: Canfrán‐Duque, Alberto, Rotllan, Noemi, Zhang, Xinbo, Fernández‐Fuertes, Marta, Ramírez‐Hidalgo, Cristina, Araldi, Elisa, Daimiel, Lidia, Busto, Rebeca, Fernández‐Hernando, Carlos, and Suárez, Yajaira
Published: 2017
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69. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk

Author: Rubín-García, María, Vitelli-Storelli, Facundo, Álvarez-Álvarez, Laura, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Serra-Majem, Luís I, Cano-Ibañez, Naomi, Tur, Josep A, Marcos-Delgado, Alba, Tresserra-Rimbau, Anna, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Vázquez-Ruiz, Zenaida, Babio, Nancy, Barragán, Rocío, Castañer-Niño, Olga, Razquin, Cristina, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, González-Palacios, Sandra, Morey, Marga, García-Rios, Antonio, Castro-Barquero, Sara, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Ruiz-Canela, Miguel, Castro-Salomó, Antoni, Pascual-Castelló, Eva Cristina, Moldon, Verónica, Bullón-Vela, Vanessa, Sorto-Sanchez, Carolina, Cenoz-Osinaga, Juan Carlos, Gutiérrez, Liliana, Mengual, Maira, Lamuela-Raventós, Rosa María, Martín-Sánchez, Vicente, PREDIMED‐Plus Trial Investigators, and European Commission
Subjects: Male, Coumaric Acids, Polyphenols, Hyperuricemia, Uric Acid, Cross-Sectional Studies, Cardiovascular Diseases, Risk Factors, Heart Disease Risk Factors, Hydroxybenzoates, Humans, Female, Cardiology and Cardiovascular Medicine
Abstract: BACKGROUND: Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. METHODS AND RESULTS: This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, −0.27 to −0.06]) and hydroxycinnamic acids (β coefficient, −0.19 [95% CI, −0.3 to −0.09]), alkylmethoxyphenols (β coefficient, −0.2 [95% CI, −0.31 to −0.1]), and methoxyphenols (β coefficient, −0.24 [95% CI, −0.34 to −0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.80 [95% CI, 0.70–0.92]; and PR, 0.79 [95% CI, 0.69–0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02–0.26]) but not with hyperuricemia. CONCLUSIONS: In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research., European Research Council (ERC) European Commission 2013-2018 340918, official funding agency for biomedical research of the Spanish government Instituto de Salud Carlos III, European Commission PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919, Especial Action Project, La Caixa Foundation 2013ACUP00194, Consejo Interinstitucional de Ciencia y Tecnologia (CICYT) AGL2016-75329-R, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2017/017, Generalitat de Catalunya SGR-2019, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, SEMERGEN (Sociedad Espanola de Medicos de Atencion Primaria), European Cooperation in Science and Technology (COST), IDISBA (Instituto de Investigacion Sanitaria Islas Baleares), European Commission CIBEROBN CB06/03 CB12/03, European Commission European Commission Joint Research Centre EAT2BENI-CE_H2020_SFS2016, Spanish Ministry of Science, Innovation and Universities for the Formacion de Profesorado Universitario FPU17/00785, Instituto de Salud Carlos III, through the Fondo de Investigacion para la Salud - European Regional Development Fund PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI16/00473, Instituto de Salud Carlos III European Commission PI14/00853 PI14/01374 PI14/00972 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI19/01560 PI16/00662 PI16/01873 PI16/01094 PI19/01332 PI14/00728 PI14/01471
Published: 2022
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70. TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis

Author: Díez-Ricote, Laura, primary, Ruiz-Valderrey, Paloma, additional, Micó, Víctor, additional, Blanco, Ruth, additional, Tomé-Carneiro, Joao, additional, Dávalos, Alberto, additional, Ordovás, José M., additional, and Daimiel, Lidia, additional
Published: 2022
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71. Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome

Author: Konieczna, Jadwiga, primary, Fiol, Miguel, additional, Colom, Antoni, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Soria-Florido, María Trinidad, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bernal-López, M. Rosa, additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Bes-Rastrollo, Maira, additional, Pascual, María, additional, Sorlí, Jose V., additional, Goday, Albert, additional, Zulet, María Ángeles, additional, Moreno-Rodriguez, Anai, additional, Carmona González, Francisco Jesús, additional, Valls-Enguix, Rafael, additional, Janer, Juana M., additional, Garcia-Rios, Antonio, additional, Casas, Rosa, additional, Gomez-Perez, Ana M., additional, Santos-Lozano, José Manuel, additional, Basterra-Gortari, F. Javier, additional, Martínez, María Ángeles, additional, Ortega-Azorin, Carolina, additional, Bayó, Joan, additional, Abete, Itziar, additional, Salaverria-Lete, Itziar, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Carres, Lourdes, additional, and Romaguera, Dora, additional
Published: 2022
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72. The antioxidant butylated hydroxyanisole potentiates the toxic effects of propylparaben in cultured mammalian cells

Author: Martín, José Manuel Pérez, Freire, Paloma Fernández, Daimiel, Lidia, Martínez-Botas, Javier, Sánchez, Covadonga Martín, Lasunción, Miguel Ángel, Peropadre, Ana, and Hazen, María José
Published: 2014
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73. Docosahexaenoic Acid Modulates the Enterocyte Caco-2 Cell Expression of MicroRNAs Involved in Lipid Metabolism1–3

Author: Gil-Zamorano, Judit, Martin, Roberto, Daimiel, Lidia, Richardson, Kris, Giordano, Elena, Nicod, Nathalie, García-Carrasco, Belén, Soares, Sara M.A., Iglesias-Gutiérrez, Eduardo, Lasunción, Miguel A., Sala-Vila, Aleix, Ros, Emilio, Ordovás, Jose M., Visioli, Francesco, and Dávalos, Alberto
Published: 2014
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74. The Epigenetically Modulated Circadian System: Implications for Nutrition and Health. Nutritional Modulation of the Circadian Epigenome

Author: Daimiel, Lidia, primary
Published: 2017
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75. Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

Author: Schröder, Helmut, Cárdenas-Fuentes, Gabriela, Martínez-González, Miguel Angel, Corella, Dolores, Vioque, Jesús, Romaguera, Dora, Alfredo Martínez, J., Tinahones, Francisco J., Miranda, José López, Estruch, Ramon, Bueno-Cavanillas, Aurora, Arós, Fernando, Marcos, Ascensión, Tur, Josep A., Warnberg, Julia, Serra-Majem, Lluis, Martín, Vicente, Vázquez, Clotilde, Lapetra, José, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José Juan, Matía-Martín, Pilar, Ros, Emilio, Castañer, Olga, Lassale, Camille, Ruiz-Canela, Miguel, Asensio, Eva M., Basora, Josep, Torres-Collado, Laura, Garcia-Rios, Antonio, Abete, Itziar, Toledo, Estefania, Buil-Cosiales, Pilar, Bullo, Mònica, Goday, Albert, Fitó, Montserrat, Salas-Salvadó, Jordi, and On behalf of the PREDIMED-Plus investigators
Published: 2018
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76. Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study

Author: Mallorquí-Bagué, Núria, Lozano-Madrid, María, Toledo, Estefanía, Corella, Dolores, Salas-Salvadó, Jordi, Cuenca-Royo, Aida, Vioque, Jesús, Romaguera, Dora, Martínez, J. Alfredo, Wärnberg, Julia, López-Miranda, José, Estruch, Ramón, Bueno-Cavanillas, Aurora, Alonso-Gómez, Ángel, Tur, Josep A., Tinahones, Francisco J., Serra-Majem, Lluís, Martín, Vicente, Lapetra, José, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Gaforio, José J., Matía, Pilar, Ros, Emilio, Granero, Roser, Buil-Cosiales, Pilar, Barragán, Rocío, Bulló, Mònica, Castañer, Olga, García-de-la-Hera, Manoli, Yáñez, Aina M., Abete, Itziar, García-Ríos, Antonio, Ruiz-Canela, Miguel, Díaz-López, Andrés, Jiménez-Murcia, Susana, Martínez-González, Miguel A., De la Torre, Rafael, and Fernández-Aranda, Fernando
Published: 2018
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77. Desired weight loss and its association with health, health behaviors and perceptions in an adult population with weight excess: One-year follow-up

Author: Bouzas, Cristina, Bibiloni, Maria del Mar, Garcia, Silvia, Mateos, David, Martínez-González, Miguel Ángel, 1957, Salas Salvadó, Jordi, Corella Piquer, Dolores, Goday Arnó, Albert, Martínez, J. Alfredo, 1957, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez Miranda, José, Estruch Riba, Ramon, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Riquelme Gallego, Blanca, Martín Sánchez, Vicente, Pintó Sala, Xavier, Gaforio, José J., Matía Martín, Pilar, Vidal i Cortada, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros Rahola, Emilio, Pascual Roquet Jalmar, Elena, Babio, Nancy, Gonzalez Monge, Inmaculada, Castañer, Olga, Abete, Itziar, Sorto Sánchez, Carolina, Benavente Marín, Juan Carlos, Torres Collado, Laura, Martin, Marian, García Ríos, Antonio, Castro Barquero, Sara, Fernández García, José C., Santos Lozano, José Manuel, Fernandez Lazaro, Cesar I., Salas Huetos, Albert, Guillem Saiz, Patricia, Zomeño, María Dolores, Zulet, M. Ángeles, Goikoetxea Bahon, Amaia, Gea, Alfredo, Nishi, Stephanie K., Schröder, Helmut, 1958, Tur, Josep A., and The PREDIMED-plus Investigators
Subjects: Síndrome metabòlica, Weight loss, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, desired weight loss, Metabolic syndrome, Hàbits sanitaris, Aprimament, Clinical trials, Mediterranean diet, PREDIMED-plus trial, Health behavior, health perception, Food Science, Assaigs clínics
Abstract: Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors. Objective: To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial. Design: Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55-75 years old) with overweight or obesity at baseline. Methods: The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: >= 0.0 kg (T1, n = 1,638); 0.0 to -4.0 kg (T2, n = 1,903), European Research Council (ERC) European Commission 20132018 340918, Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919, Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensive sobre la actividad fisica Cohorte PREDIMED-Plus grant, Recercaixa Grant 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2017/017 European Cooperation in Science and Technology (COST) European Commission CA16112, Balearic Islands Health Research Institute (IDISBA), European Commission CIBEROBN CB06/03 CB12/03 European Commission European Commission Joint Research Centre EAT2BENICE_H2020_SFS2016, Fundacio La Marato TV3 201630.10, Fernando Tarongi Bauza Grant, 'Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund' PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017, the Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI14/00853 PI14/01374 PI14/00972 PI14/00728 PI14/01471 PI16/00473 PI16/00662 PI16/01873 PI16/01094 PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI19/01226, "Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund" PI19/00781 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158
Published: 2022

78. Unsuccessful Detection of Plant MicroRNAs in Beer, Extra Virgin Olive Oil and Human Plasma After an Acute Ingestion of Extra Virgin Olive Oil

Author: Micó, Victor, Martín, Roberto, Lasunción, Miguel A., Ordovás, Jose M., and Daimiel, Lidia
Published: 2016
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79. Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

Author: Valle-Hita, Cristina, primary, Becerra-Tomás, Nerea, additional, Díaz-López, Andrés, additional, Vázquez-Ruiz, Zenaida, additional, Megías, Isabel, additional, Corella, Dolores, additional, Goday, Albert, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Amengual-Galbarte, Angela, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, García-Arellano, Ana, additional, Barragán, Rocío, additional, Fitó, Montse, additional, Peña-Orihuela, Patricia J., additional, Asencio-Aznar, Alberto, additional, Gómez-Gracia, Enrique, additional, Martinez-Urbistondo, Diego, additional, Morey, Marga, additional, Casas, Rosa, additional, Garrido-Garrido, Eva María, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Goñi, Estibaliz, additional, Ortega-Azorín, Carolina, additional, Castañer, Olga, additional, Garcia-Rios, Antonio, additional, Gisbert-Sellés, Cristina, additional, Sayón-Orea, Carmen, additional, Schröder, Helmut, additional, Salas-Salvadó, Jordi, additional, and Babio, Nancy, additional
Published: 2022
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80. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Author: Marhuenda-Muñoz, María, primary, Domínguez-López, Inés, additional, Langohr, Klaus, additional, Tresserra-Rimbau, Anna, additional, Martínez González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, María Dolores, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Angel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Ll., additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Fernández de la Puente Cervera, María, additional, Barragán, Rocío, additional, Fitó, Montse, additional, Tojal-Sierra, Lucas, additional, Gómez-Gracia, Enrique, additional, Zazo, Juan Manuel, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Gómez-Pérez, Ana M., additional, Santos-Lozano, José Manuel, additional, Vázquez-Ruiz, Zenaida, additional, Atzeni, Alessandro, additional, Asensio, Eva M., additional, Gili-Riu, M. Mar, additional, Bullon, Vanessa, additional, Moreno-Rodriguez, Anai, additional, Lecea, Oscar, additional, Babio, Nancy, additional, Peñas Lopez, Francesca, additional, Gómez Melis, Guadalupe, additional, and Lamuela-Raventós, Rosa M., additional
Published: 2022
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81. Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis

Author: Micó, Víctor, primary, San-Cristobal, Rodrigo, additional, Martín, Roberto, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, García-Arellano, Ana, additional, Pertusa-Martinez, Salvador, additional, Chaplin, Alice, additional, Garcia-Rios, Antonio, additional, Muñoz Bravo, Carlos, additional, Schröder, Helmut, additional, Babio, Nancy, additional, Sorli, Jose V., additional, Gonzalez, Jose I., additional, Martinez-Urbistondo, Diego, additional, Toledo, Estefania, additional, Bullón, Vanessa, additional, Ruiz-Canela, Miguel, additional, Portillo, María Puy-, additional, Macías-González, Manuel, additional, Perez-Diaz-del-Campo, Nuria, additional, García-Gavilán, Jesús, additional, Daimiel, Lidia, additional, and Martínez, J. Alfredo, additional
Published: 2022
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82. Dietary diversity and depression: cross-sectional and longitudinal analyses in Spanish adult population with metabolic syndrome. Findings from PREDIMED-Plus trial

Author: Cano-Ibáñez, Naomi, primary, Serra-Majem, Lluis, additional, Martín-Peláez, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Lassale, Camille, additional, Martínez, Jose Alfredo, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Gómez-Pérez, Ana María, additional, Lapetra, José, additional, Fernández-Aranda, Fernando, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A, additional, Cubelos, Naiara, additional, Pintó, Xavier, additional, Gaforio, José Juan, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Calderón, Cristina, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Gea, Alfredo, additional, Babio, Nancy, additional, Gimenez-Alba, Ignacio Manuel, additional, Zomeño-Fajardo, María Dolores, additional, Abete, Itziar, additional, Tojal Sierra, Lucas, additional, Romero-Galisteo, Rita P, additional, García de la Hera, Manoli, additional, Martín-Padillo, Marian, additional, García-Ríos, Antonio, additional, Casas, Rosa M, additional, Fernández-García, JC, additional, Santos-Lozano, José Manuel, additional, Toledo, Estefanía, additional, Becerra-Tomas, Nerea, additional, Sorli, Jose V, additional, Schröder, Helmut, additional, Zulet, María A, additional, Sorto-Sánchez, Carolina, additional, Diez-Espino, Javier, additional, Gómez-Martínez, Carlos, additional, Fitó, Montse, additional, and Sánchez-Villegas, Almudena, additional
Published: 2022
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83. Associations Between the Modified Food Standard Agency Nutrient Profiling System Dietary Index and Cardiovascular Risk Factors in an Elderly Population

Author: Khoury, Nadine, primary, Gómez-Donoso, Clara, additional, Martínez, María Ángeles, additional, Martínez-González, Miguel Ángel, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, León-Acuña, Ana, additional, Tinahones, Francisco J., additional, Santos-Lozano, José M., additional, Serra-Majem, Luís, additional, Massó Guijarro, Paloma, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Bes-Rastrollo, Maira, additional, Barragan, Rocio, additional, Castañer, Olga, additional, Torres-Peña, Jose D., additional, Notario-Barandiaran, Leyre, additional, Muñoz-Bravo, Carlos, additional, Abete, Itziar, additional, Prohens, Lara, additional, Cano-Ibáñez, Naomi, additional, Tojal Sierra, Lucas, additional, Fernández-García, José Carlos, additional, Sayon-Orea, Carmen, additional, Pascual, Maria, additional, Sorli, Jose V., additional, Zomeño, Dolores, additional, Peña-Orihuela, Patricia J., additional, Signes-Pastor, Antonio J., additional, Basterra-Gortari, F. Javier, additional, Schröeder, Helmut, additional, Salas Salvadó, Jordi, additional, and Babio, Nancy, additional
Published: 2022
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84. Impact of Phenol-Enriched virgin olive oils on the Postprandial Levels of circulating microRNAs reted to carladiovascular disease

Author: Fundación Salud 2000, Ministerio de Economía y Competitividad (España), Ministerio de Educación y Ciencia (España), European Commission, Daimiel, Lidia [0000-0001-9898-6629], Valls, Rosa-Maria [0000-0002-3351-0942], Daimiel, Lidia, Micó, Víctor, Valls, Rosa-Maria, Pedret, Anna, Motilva, María-José, Rubió, Laura, Fitó, Montserrat, Farràs, Marta, Covas, María Isabel, Solá, Rosa, Ordovás, José M., Fundación Salud 2000, Ministerio de Economía y Competitividad (España), Ministerio de Educación y Ciencia (España), European Commission, Daimiel, Lidia [0000-0001-9898-6629], Valls, Rosa-Maria [0000-0002-3351-0942], Daimiel, Lidia, Micó, Víctor, Valls, Rosa-Maria, Pedret, Anna, Motilva, María-José, Rubió, Laura, Fitó, Montserrat, Farràs, Marta, Covas, María Isabel, Solá, Rosa, and Ordovás, José M.
Abstract: [Scope] We investigate the postprandial modulation of cardiovascular‐related microRNAs elicited by extra virgin olive oil (EVOOs) containing different levels of their own polyphenols. [Methods and results] It is randomized, postprandial, parallel, double‐blind study. Twelve healthy participants consumed 30 mL of EVOO containing low (L‐EVOO; 250 mg total phenols kg−1 of oil), medium (M‐EVOO; 500 mg total phenols kg−1 of oil), and high (H‐EVOO; 750 mg total phenols kg−1 of oil) enriched EVOOs. Postprandial plasma microRNAs levels are analyzed by real‐time quantitative PCR. The results show that L‐EVOO intake is associated with decreased let‐7e‐5p and miR‐328a‐3p levels and increased miR‐17‐5p and miR‐20a‐5p, concentrations. M‐EVOO decreases plasma let‐7e‐5p and increases miR‐17‐5p, miR‐20a‐5p, and miR‐192‐5p levels. Finally, H‐EVOO decreases let‐7e‐5p, miR‐10a‐5p, miR‐21‐5p, and miR‐26b‐5p levels. [Conclusion] During the postprandial state, the levels of let‐7e‐5p decrease with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol kg−1 olive oil. Moreover, the miR‐17‐92 cluster increases by low and medium polyphenol content suggesting a role in fatty acid metabolism and nutrient sensing. Thus, postprandial modulation of circulating microRNAs levels could be a potential mechanism for the cardiovascular benefits associated with EVOO intake.
Published: 2020

85. Impact of Phenol-Enriched virgin olive oils on the Postprandial Levels of circulating microRNAs reted to carladiovascular disease

Author: Daimiel, Lidia, Micó, Víctor, Valls, Rosa M, Pedret, Anna, Motilva, María José, Rubió, Laura, Fitó, Montse, Farrás, Marta, Covas, María Isabel, Solá, Rosa, Ordovás, José M., 0000-0001-9898-6629, 0000-0002-3351-0942, Fundación Salud 2000, Ministerio de Economía y Competitividad (España), Ministerio de Educación y Ciencia (España), European Commission, Daimiel, Lidia [0000-0001-9898-6629], Valls, Rosa-Maria [0000-0002-3351-0942], Daimiel, Lidia, and Valls, Rosa-Maria
Subjects: 0301 basic medicine, Adult, Blood Glucose, Male, Mediterranean diet, Nutrient sensing, extra virgin olive oil, 03 medical and health sciences, chemistry.chemical_compound, Double-Blind Method, Phenols, cardiovascular disease, Extra virgin olive oil, Phenol, Humans, Computer Simulation, Food science, Olive Oil, Research Articles, 030109 nutrition & dietetics, Fatty acid metabolism, biomarkers, mediterranean diet, Middle Aged, Postprandial Period, Cardiovascular disease, Lipids, microRNAs, Circulating MicroRNA, MicroRNAs, 030104 developmental biology, Postprandial, chemistry, Polyphenol, Cardiovascular Diseases, Food, Fortified, Female, Endothelium, Vascular, Cell-Free Nucleic Acids, Biomarkers, Food Science, Biotechnology, Research Article
Abstract: [Scope] We investigate the postprandial modulation of cardiovascular‐related microRNAs elicited by extra virgin olive oil (EVOOs) containing different levels of their own polyphenols. [Methods and results] It is randomized, postprandial, parallel, double‐blind study. Twelve healthy participants consumed 30 mL of EVOO containing low (L‐EVOO; 250 mg total phenols kg−1 of oil), medium (M‐EVOO; 500 mg total phenols kg−1 of oil), and high (H‐EVOO; 750 mg total phenols kg−1 of oil) enriched EVOOs. Postprandial plasma microRNAs levels are analyzed by real‐time quantitative PCR. The results show that L‐EVOO intake is associated with decreased let‐7e‐5p and miR‐328a‐3p levels and increased miR‐17‐5p and miR‐20a‐5p, concentrations. M‐EVOO decreases plasma let‐7e‐5p and increases miR‐17‐5p, miR‐20a‐5p, and miR‐192‐5p levels. Finally, H‐EVOO decreases let‐7e‐5p, miR‐10a‐5p, miR‐21‐5p, and miR‐26b‐5p levels. [Conclusion] During the postprandial state, the levels of let‐7e‐5p decrease with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol kg−1 olive oil. Moreover, the miR‐17‐92 cluster increases by low and medium polyphenol content suggesting a role in fatty acid metabolism and nutrient sensing. Thus, postprandial modulation of circulating microRNAs levels could be a potential mechanism for the cardiovascular benefits associated with EVOO intake., The present work was funded by Fundación Salud 2000 – Merck-Serono research fellowship granted to J.M.O. in the 2013 call V.M. was supported by a Manuel de Oya fellowship of the Fundación Cerveza y Salud. This work was supported by grants: the VOHF Study (AGL2009-13517-C03), the MEFOPC Project (AGL2012-40144-C03) from the Spanish Ministry of Education and Science and the grants PI14/01374 and PI17/00508 granted to L.D. by Instituto de Salud Carlos III through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund. A.P. has Torres Quevedo contract (Subprograma Estatal de Incorporación, Plan Estatal de Investigación Científica y Técnica y de Innovación). The authors thank VOHF participants for their enthusiastic collaboration
Published: 2020

86. Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

Author: Springer Science and Business Media LLC, Barradas, Marta, Plaza, Adrián, Colmenarejo, Gonzalo, Lázaro, Iolanda, Costa-Machado, Luis Filipe, Martín-Hernández, Roberto, Micó, Victor, López-Aceituno, José Luis, Herranz, Jesús, Pantoja, Cristina, Tejero, Hector, Diaz-Ruiz, Alberto, Al-Shahrour, Fatima, Daimiel, Lidia, Loria Kohen, Viviana Constanza, Ramírez de Molina, Ana, Efeyan, Alejo, Serrano, Manuel, Pozo, Oscar J., Sala-Vila, Aleix, Fernández-Marcos, Pablo J., Springer Science and Business Media LLC, Barradas, Marta, Plaza, Adrián, Colmenarejo, Gonzalo, Lázaro, Iolanda, Costa-Machado, Luis Filipe, Martín-Hernández, Roberto, Micó, Victor, López-Aceituno, José Luis, Herranz, Jesús, Pantoja, Cristina, Tejero, Hector, Diaz-Ruiz, Alberto, Al-Shahrour, Fatima, Daimiel, Lidia, Loria Kohen, Viviana Constanza, Ramírez de Molina, Ana, Efeyan, Alejo, Serrano, Manuel, Pozo, Oscar J., Sala-Vila, Aleix, and Fernández-Marcos, Pablo J.
Abstract: Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity., Gobierno Regional de la Comunidad de Madrid, Asociación Española contra el Cáncer, Ministerio de Ciencia, Innovación y Universidades, Fundación Ramón Areces, Hospital Ramón y Cajal, Fundación “laCaixa”, Portuguese Foundation for Science and Technology, Depto. de Nutrición y Ciencia de los Alimentos, Fac. de Farmacia, TRUE, pub, APC financiada por la UCM
Published: 2022

87. Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Author: Tresserra Rimbau, Anna, Castro Barquero, Sara, Becerra Tomás, Nerea, Babio, Nancy, Martínez González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel M., Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, Cano Ibáñez, Naomi, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Francisco Javier, Fernández de la Puente, María, Asensio, Eva María, Castañer, Olga, Bullón Vela, Vanessa, Tojal Sierra, Lucas, Gómez Gracia, Enrique, Cases Pérez, Eugenio, Konieczna, Jadwiga, García Ríos, Antonio, Casañas Quintana, Tamara, Bernal López, María Rosa, Santos Lozano, José Manuel, Esteve Luque, Virginia, Bouzas, Cristina, Vázquez Ruiz, Zenaida, Palau Galindo, Antoni, Barragan, Rocio, López Grau, Mercè, Razquín, Cristina, Goicolea Güemez, Leire, Toledo, Estefanía, Vergaz, Manel Vila, Lamuela Raventós, Rosa María, Salas Salvadó, Jordi, Tresserra Rimbau, Anna, Castro Barquero, Sara, Becerra Tomás, Nerea, Babio, Nancy, Martínez González, Miguel Ángel, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso Gómez, Ángel M., Wärnberg, Julia, Martínez, José Alfredo, Serra Majem, Luís, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López Miranda, José, Cano Ibáñez, Naomi, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Francisco Javier, Fernández de la Puente, María, Asensio, Eva María, Castañer, Olga, Bullón Vela, Vanessa, Tojal Sierra, Lucas, Gómez Gracia, Enrique, Cases Pérez, Eugenio, Konieczna, Jadwiga, García Ríos, Antonio, Casañas Quintana, Tamara, Bernal López, María Rosa, Santos Lozano, José Manuel, Esteve Luque, Virginia, Bouzas, Cristina, Vázquez Ruiz, Zenaida, Palau Galindo, Antoni, Barragan, Rocio, López Grau, Mercè, Razquín, Cristina, Goicolea Güemez, Leire, Toledo, Estefanía, Vergaz, Manel Vila, Lamuela Raventós, Rosa María, and Salas Salvadó, Jordi
Abstract: The PREDIMED-Plus trial was supported by the Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated Fondo de Investigaciones Sanitarias projects leaded by J.S.-S. and J.V. (Josep Vidal), including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158)), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil for the PTREDIMED-Plus study, and, Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D., Unión Europea, Consejo Europeo de Investigación, Ministerio de Ciencia y Innovación (España), Ministerio de Economía e Industria (España), Junta de Andalucía. Consejería de Salud, Generalitat Valenciana, Gobierno de Islas Baleares, Instituto de Salud Carlos III, Recercaixa, ICREA, PREDIMED-Plus, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Depto. de Medicina, Fac. de Medicina, TRUE, pub
Published: 2022

88. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

Author: Medicina, Medikuntza, Martín-Peláez, Sandra, Serra Majem, Lluis, Cano Ibáñez, Naomi, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Lassale, Camille, Martínez, J. Alfredo, Alonso Gómez, Ángel María, Warnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Fernández Aranda, Fernando, Bueno Cavanillas, Aurora, Tur, Josep A., Martín, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Nishi, Stephanie K., Sorli, José Vicente, Malcampo, Mireia, Zulet, M. Ángeles, Moreno Rodríguez, Anai, Cueto Galán, Raquel, Vivancos aparicio, Diego, Colom, Antoni, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Váquez, Zenaida, Gómez Martínez, Carlos, Ortega Azorín, Carolina, Del ValI, José Luis, Abete, Itziar, Goikoetxea Bahon, Amaia, Pascual, Elena, Becerra Tomás, Nerea, Chillarón, Juan J., Sánchez Villegas, Almudena, Medicina, Medikuntza, Martín-Peláez, Sandra, Serra Majem, Lluis, Cano Ibáñez, Naomi, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Lassale, Camille, Martínez, J. Alfredo, Alonso Gómez, Ángel María, Warnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Fernández Aranda, Fernando, Bueno Cavanillas, Aurora, Tur, Josep A., Martín, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Nishi, Stephanie K., Sorli, José Vicente, Malcampo, Mireia, Zulet, M. Ángeles, Moreno Rodríguez, Anai, Cueto Galán, Raquel, Vivancos aparicio, Diego, Colom, Antoni, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Váquez, Zenaida, Gómez Martínez, Carlos, Ortega Azorín, Carolina, Del ValI, José Luis, Abete, Itziar, Goikoetxea Bahon, Amaia, Pascual, Elena, Becerra Tomás, Nerea, Chillarón, Juan J., and Sánchez Villegas, Almudena
Abstract: BACKGROUND: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. METHODS AND FINDINGS: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). CONCLUSIONS: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
Published: 2022

89. Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort

Author: Medicina, Medikuntza, Martínez Urbistondo, Diego, San Cristóbal, Rodrigo, Villares, Paula, Martínez González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Del Val, José Luis, Ordovás, José María, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Marcos, Alba, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Bullón Vela, María Vanessa, Palau Galindo, Antoni, Masagué, Marta, Abete, Itziar, Moreno Rodríguez, Anai, Candela García, Inmaculada, Konieczna, Jadwiga, García Ríos, Antonio, Lecea Juárez, Oscar, Martín Lujan, Francisco Manuel, Goday, Albert, Zulet, M. Ángeles, Vaquero Luna, Jessica, Sayón Orea, María del Carmen, Megías, Isabel, Baltasar, Enric, Martínez Hernández, J. Alfredo, Daimiel, Lidia, Medicina, Medikuntza, Martínez Urbistondo, Diego, San Cristóbal, Rodrigo, Villares, Paula, Martínez González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Del Val, José Luis, Ordovás, José María, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Marcos, Alba, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Bullón Vela, María Vanessa, Palau Galindo, Antoni, Masagué, Marta, Abete, Itziar, Moreno Rodríguez, Anai, Candela García, Inmaculada, Konieczna, Jadwiga, García Ríos, Antonio, Lecea Juárez, Oscar, Martín Lujan, Francisco Manuel, Goday, Albert, Zulet, M. Ángeles, Vaquero Luna, Jessica, Sayón Orea, María del Carmen, Megías, Isabel, Baltasar, Enric, Martínez Hernández, J. Alfredo, and Daimiel, Lidia
Abstract: Objective. To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). MethodsBaseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. ResultsData from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (beta 0.64 vs beta 0.05 per er-MeDiet adherence point, p< 0.01) and PA (beta 0.05 vs beta 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. ConclusionThe evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870).
Published: 2022

90. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Author: Medicina, Medikuntza, Valle Hita, Cristina, Díaz López, Andrés, Becerra Tomás, Andrea, Martínez González, Miguel Ángel, Ruiz García, Verónica, Corella, Dolores, Goday, Albert, Martínez Hernández, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Cano Ibáñez, Noemí, Tur, Josep A., Rubín García, María, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Sorlí, José V., Roca, C., Abete, Itziar, Moreno Rodríguez, Anai, Crespo Oliva, Edelys, Candela García, Inmaculada, Morey, Margarita, García Ríos, Antonio, Casas, Rosa, Fernández García, José Carlos, Santos Lozano, José Manuel, Díez Espino, Javier, Ortega Azorín, Carolina, Comas, M., Zulet, M. Ángeles, Sorto Sánchez, Carolina, Ruiz Canela, Miguel, Fitó, Montse, Salas Salvadó, Jordi, Babio, Nancy, Medicina, Medikuntza, Valle Hita, Cristina, Díaz López, Andrés, Becerra Tomás, Andrea, Martínez González, Miguel Ángel, Ruiz García, Verónica, Corella, Dolores, Goday, Albert, Martínez Hernández, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Cano Ibáñez, Noemí, Tur, Josep A., Rubín García, María, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Sorlí, José V., Roca, C., Abete, Itziar, Moreno Rodríguez, Anai, Crespo Oliva, Edelys, Candela García, Inmaculada, Morey, Margarita, García Ríos, Antonio, Casas, Rosa, Fernández García, José Carlos, Santos Lozano, José Manuel, Díez Espino, Javier, Ortega Azorín, Carolina, Comas, M., Zulet, M. Ángeles, Sorto Sánchez, Carolina, Ruiz Canela, Miguel, Fitó, Montse, Salas Salvadó, Jordi, and Babio, Nancy
Abstract: Purpose To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS). Methods We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m(2)) or >= 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate. Results Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (beta: 1.87 ml/min/1.73m(2); 95% CI: 1.00-2.73) and had lower odds of >= 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (beta: - 0.87 ml/min/1.73m(2); 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75). Conclusions Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health. Trial Registration Number: ISRCTN89898870 (Data of registration: 2014).
Published: 2022

91. Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF)

Author: Medicina, Medikuntza, Martínez Pérez, Celia, Daimiel, Lidia, Climent Mainar, Cristina, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martínez Hernández, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Javier, Babio, Nancy, Guillem Saiz, Patricia, Zomeño, María Dolores, Abete, Itziar, Vaquero Luna, Jessica, Barón López, Francisco Javier, González Palacios, Sandra, Konieczna, Jadwiga, García Ríos, Antonio, Bernal López, María Rosa, Santos Lozano, José Manuel, Bes Rastrollo, Maira, Khoury, Nadine, Saiz, Carmen, Pérez Vega, Karla Alejandra, Zulet, M. Ángeles, Tojal Sierra, Lucas, Vázquez Ruiz, Zenaida, Martínez, María Ángeles, Malcampo, Mireia, Ordovás, José María, San Cristóbal, Rodrigo, Medicina, Medikuntza, Martínez Pérez, Celia, Daimiel, Lidia, Climent Mainar, Cristina, Martínez González, Miguel Ángel, Salas Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martínez Hernández, J. Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xabier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Basterra, Javier, Babio, Nancy, Guillem Saiz, Patricia, Zomeño, María Dolores, Abete, Itziar, Vaquero Luna, Jessica, Barón López, Francisco Javier, González Palacios, Sandra, Konieczna, Jadwiga, García Ríos, Antonio, Bernal López, María Rosa, Santos Lozano, José Manuel, Bes Rastrollo, Maira, Khoury, Nadine, Saiz, Carmen, Pérez Vega, Karla Alejandra, Zulet, M. Ángeles, Tojal Sierra, Lucas, Vázquez Ruiz, Zenaida, Martínez, María Ángeles, Malcampo, Mireia, Ordovás, José María, and San Cristóbal, Rodrigo
Abstract: Background: Recent lifestyle changes include increased consumption of highly processed foods (HPF), which has been associated with an increased risk of non-communicable diseases (NCDs). However, nutritional information relies on the estimation of HPF consumption from food-frequency questionnaires (FFQ) that are not explicitly developed for this purpose. We aimed to develop a short screening questionnaire of HPF consumption (sQ-HPF) that integrates criteria from the existing food classification systems. Methods: Data from 4400 participants (48.1% female and 51.9% male, 64.9 +/- 4.9 years) of the Spanish PREDIMED-Plus ("PREvention with MEDiterranean DIet") trial were used for this analysis. Items from the FFQ were classified according to four main food processing-based classification systems (NOVA, IARC, IFIC and UNC). Participants were classified into tertiles of HPF consumption according to each system. Using binomial logistic regression, food groups associated with agreement in the highest tertile for at least two classification systems were chosen as items for the questionnaire. ROC analysis was used to determine cut-off points for the frequency of consumption of each item, from which a score was calculated. Internal consistency of the questionnaire was assessed through exploratory factor analysis (EFA) and Cronbach's analysis, and agreement with the four classifications was assessed with weighted kappa coefficients. Results: Regression analysis identified 14 food groups (items) associated with high HPF consumption for at least two classification systems. EFA showed that items were representative contributors of a single underlying factor, the "HPF dietary pattern" (factor loadings around 0.2). We constructed a questionnaire asking about the frequency of consumption of those items. The threshold frequency of consumption was selected using ROC analysis. Comparison of the four classification systems and the sQ-HPF showed a fair to high agreement. Significant changes
Published: 2022

92. Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF)

Author: Universidad de Sevilla. Departamento de Medicina, Martínez Pérez, Celia, Daimiel, Lidia, Climent Mainar, Cristina, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Santos Lozano, José Manuel, San Cristóbal, Rodrigo, Universidad de Sevilla. Departamento de Medicina, Martínez Pérez, Celia, Daimiel, Lidia, Climent Mainar, Cristina, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Santos Lozano, José Manuel, and San Cristóbal, Rodrigo
Abstract: Background Recent lifestyle changes include increased consumption of highly processed foods (HPF), which has been associated with an increased risk of non-communicable diseases (NCDs). However, nutritional information relies on the estimation of HPF consumption from food-frequency questionnaires (FFQ) that are not explicitly developed for this purpose. We aimed to develop a short screening questionnaire of HPF consumption (sQ-HPF) that integrates criteria from the existing food classification systems. Methods Data from 4400 participants (48.1% female and 51.9% male, 64.9 ± 4.9 years) of the Spanish PREDIMED-Plus (“PREvention with MEDiterranean DIet”) trial were used for this analysis. Items from the FFQ were classified according to four main food processing-based classification systems (NOVA, IARC, IFIC and UNC). Participants were classified into tertiles of HPF consumption according to each system. Using binomial logistic regression, food groups associated with agreement in the highest tertile for at least two classification systems were chosen as items for the questionnaire. ROC analysis was used to determine cut-off points for the frequency of consumption of each item, from which a score was calculated. Internal consistency of the questionnaire was assessed through exploratory factor analysis (EFA) and Cronbach’s analysis, and agreement with the four classifications was assessed with weighted kappa coefficients. Results Regression analysis identified 14 food groups (items) associated with high HPF consumption for at least two classification systems. EFA showed that items were representative contributors of a single underlying factor, the “HPF dietary pattern” (factor loadings around 0.2). We constructed a questionnaire asking about the frequency of consumption of those items. The threshold frequency of consumption was selected using ROC analysis. Comparison of the four classification systems and the sQ-HPF showed a fair to high agreement. Significant changes in l
Published: 2022

93. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Author: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), European Research Council, Junta de Andalucía, Generalitat Valenciana, Marhuenda-Muñoz, María, Domínguez-López, Inés, Langohr, Klaus, Tresserra-Rimbau, Anna, Martínez González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Fernández de la Puente Cervera, María, Barragán, Rocío, Fitó, Montserrat, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, Zazo, Juan Manuel, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Atzeni, Alessandro, Asensio, Eva M., Gili-Riu, M. Mar, Bullon, Vanessa, Moreno-Rodríguez, Anai, Lecea, Óscar, Babio, Nancy, Peñas Lopez, Francesca, Gómez Melis, Guadalupe, Lamuela-Raventós, Rosa M., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), European Research Council, Junta de Andalucía, Generalitat Valenciana, Marhuenda-Muñoz, María, Domínguez-López, Inés, Langohr, Klaus, Tresserra-Rimbau, Anna, Martínez González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Fernández de la Puente Cervera, María, Barragán, Rocío, Fitó, Montserrat, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, Zazo, Juan Manuel, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Atzeni, Alessandro, Asensio, Eva M., Gili-Riu, M. Mar, Bullon, Vanessa, Moreno-Rodríguez, Anai, Lecea, Óscar, Babio, Nancy, Peñas Lopez, Francesca, Gómez Melis, Guadalupe, and Lamuela-Raventós, Rosa M.
Abstract: Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [−2.79 mg/dl (95% CI: −4.25, −1.34) and −5.15 mg/dl (95% CI: −7.38, −2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 % (95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001].
Published: 2022

94. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Generalitat Valenciana, Oncina-Canovas, Alejandro, Vioque, Jesús, González-Palacios, Sandra, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. A., Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Bernal-López, María Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Babio, Nancy, Sorlí, Jose V., Schröder, Helmut, Zulet, M. Ángeles, Sorto-Sánchez, Carolina2, Barón-López, Francisco Javier, Compañ-Gabucio, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Asensio, Eva M., Soldevila, Núria, Abete, Itziar, Goicolea-Güemez, Leire, Buil-Cosiales, Pilar, García-Gavilán, Jesús F., Canals, Erik, Torres-Collado, Laura, García de la Hera, Manuela, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Generalitat Valenciana, Oncina-Canovas, Alejandro, Vioque, Jesús, González-Palacios, Sandra, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. A., Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Bernal-López, María Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Babio, Nancy, Sorlí, Jose V., Schröder, Helmut, Zulet, M. Ángeles, Sorto-Sánchez, Carolina2, Barón-López, Francisco Javier, Compañ-Gabucio, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Asensio, Eva M., Soldevila, Núria, Abete, Itziar, Goicolea-Güemez, Leire, Buil-Cosiales, Pilar, García-Gavilán, Jesús F., Canals, Erik, Torres-Collado, Laura, and García de la Hera, Manuela
Abstract: [Purpose]: We explored the cross-sectional association between the adherence to three different provegetarian (PVG) food patterns defined as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. [Methods]: We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus randomized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fish and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and coffee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them differently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. [Results]: A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefficients for 5th vs. 1st quintile were − 0.16 (95% CI: − 0.33 to 0.01) for gPVG (p trend: 0.015), and − 0.23 (95% CI: − 0.41 to − 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). [Conclusion]: Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher adherence to uPVG was associated to higher cardiovascular risk.
Published: 2022

95. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Universitat Rovira i Virgili, Oncina-Canovas, Alejandro; Vioque, Jesus; Gonzalez-Palacios, Sandra; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Zomeno, Dolores; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Bernal-Lopez, Rosa M.; Lapetra, Jose; Luis Serra-Majem, J.; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin-Sanchez, Vicente; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emili; Toledo, Estefania; Babio, Nancy; Sorli, Jose, V; Schroder, Helmut; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Javier Baron-Lopez, Francisco; Compan-Gabucio, Laura; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Asensio, Eva M.; Soldevila, Nuria; Abete, Itziar; Goicolea-Guemez, Leire; Buil-Cosiales, Pilar; Garcia-Gavilan, Jesus F.; Canals, Erik; Torres-Collado, Laura; Garcia-de-la-Hera, Manuela, Universitat Rovira i Virgili, and Oncina-Canovas, Alejandro; Vioque, Jesus; Gonzalez-Palacios, Sandra; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Zomeno, Dolores; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Bernal-Lopez, Rosa M.; Lapetra, Jose; Luis Serra-Majem, J.; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin-Sanchez, Vicente; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emili; Toledo, Estefania; Babio, Nancy; Sorli, Jose, V; Schroder, Helmut; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Javier Baron-Lopez, Francisco; Compan-Gabucio, Laura; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Asensio, Eva M.; Soldevila, Nuria; Abete, Itziar; Goicolea-Guemez, Leire; Buil-Cosiales, Pilar; Garcia-Gavilan, Jesus F.; Canals, Erik; Torres-Collado, Laura; Garcia-de-la-Hera, Manuela
Abstract: Purpose We explored the cross-sectional association between the adherence to three different provegetarian (PVG) food patterns defined as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. Methods We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus randomized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fish and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and coffee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them differently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. Results A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefficients for 5th vs. 1st quintile were - 0.16 (95% CI: - 0.33 to 0.01) for gPVG (p trend: 0.015), and - 0.23 (95% CI: - 0.41 to - 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). Conclusion Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher a
Published: 2022

96. Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome

Author: Universitat Rovira i Virgili, Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Trinidad Soria-Florido, Maria; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Vioque, Jesus; Lopez-Miranda, Jose; Estruch, Ramon; Rosa Bernal-Lopez, M.; Lapetra, Jose; Serra-Majem, Lluis; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin Sanchez, Vicente; Pinto, Xavier; Gaforio, Jose J.; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Bes-Rastrollo, Maira; Pascual, Maria; Sorli, Jose, V; Goday, Albert; Angeles Zulet, Maria; Moreno-Rodriguez, Anai; Carmona Gonzalez, Francisco Jesus; Valls-Enguix, Rafael; Janer, Juana M.; Garcia-Rios, Antonio; Casas, Rosa; Gomez-Perez, Ana M.; Manuel Santos-Lozano, Jose; Javier Basterra-Gortari, F.; Angeles Martinez, Maria; Ortega-Azorin, Carolina; Bayo, Joan; Abete, Itziar; Salaverria-Lete, Itziar; Ruiz-Canela, Miguel; Babio, Nancy; Carres, Lourdes; Romaguera, Dora, Universitat Rovira i Virgili, and Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Trinidad Soria-Florido, Maria; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Vioque, Jesus; Lopez-Miranda, Jose; Estruch, Ramon; Rosa Bernal-Lopez, M.; Lapetra, Jose; Serra-Majem, Lluis; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin Sanchez, Vicente; Pinto, Xavier; Gaforio, Jose J.; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Bes-Rastrollo, Maira; Pascual, Maria; Sorli, Jose, V; Goday, Albert; Angeles Zulet, Maria; Moreno-Rodriguez, Anai; Carmona Gonzalez, Francisco Jesus; Valls-Enguix, Rafael; Janer, Juana M.; Garcia-Rios, Antonio; Casas, Rosa; Gomez-Perez, Ana M.; Manuel Santos-Lozano, Jose; Javier Basterra-Gortari, F.; Angeles Martinez, Maria; Ortega-Azorin, Carolina; Bayo, Joan; Abete, Itziar; Salaverria-Lete, Itziar; Ruiz-Canela, Miguel; Babio, Nancy; Carres, Lourdes; Romaguera, Dora
Abstract: Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (beta 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS.
Published: 2022

97. Interaction of ACEI antihypertensive agent's administration with the inflammatory status at admission concerning COVID-19 clinical stay outcomes

Author: Martínez-Urbistondo, Maria, Moreno-Torres, Víctor, Mora-Vargas, Alberto, Expósito-Palomo, Esther, Castejón-Díaz, Raquel, Daimiel, Lidia, Ramos-Lopez, Omar, San-Cristóbal, Rodrigo, Vargas, Juan A., and Martínez, J. Alfredo
Published: 2022
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98. Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort

Author: Martínez-Urbistondo, Diego, primary, San-Cristóbal, Rodrigo, additional, Villares, Paula, additional, Martínez-González, Miguel Ángel, additional, Babio, Nancy, additional, Corella, Dolores, additional, del Val, José Luis, additional, Ordovás, José Ma, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Marcos, Alba, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Bullón Vela, María Vanessa, additional, Palau, Antoni, additional, Sorli, Jose V., additional, Masagué, Marta, additional, Abete, Itziar, additional, Moreno-Rodríguez, Anai, additional, Candela-García, Inma, additional, Konieczna, Jadwiga, additional, García-Ríos, Antonio, additional, Juárez, Oscar Lecea, additional, Portolés, Olga, additional, Martín, Paco, additional, Goday, Albert, additional, Zulet, M Ángeles, additional, Vaquero-Luna, Jessica, additional, Orea, María del Carmen Sayón, additional, Megías, Isabel, additional, Baltasar, Enric, additional, Martínez, J. Alfredo, additional, and Daimiel, Lidia, additional
Published: 2022
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99. Longwise Cluster Analysis for the Prediction of COVID-19 Severity within 72 h of Admission: COVID-DATA-SAVE-LIFES Cohort

Author: San-Cristobal, Rodrigo, primary, Martín-Hernández, Roberto, additional, Ramos-Lopez, Omar, additional, Martinez-Urbistondo, Diego, additional, Micó, Víctor, additional, Colmenarejo, Gonzalo, additional, Villares Fernandez, Paula, additional, Daimiel, Lidia, additional, and Martínez, Jose Alfredo, additional
Published: 2022
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100. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

Author: Martín-Peláez, Sandra, primary, Serra-Majem, Lluis, additional, Cano-Ibáñez, Naomi, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Lassale, Camille, additional, Martínez, Jose Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Fernández-Aranda, Fernando, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Nishi, Stephanie K., additional, Sorli, Jose V., additional, Malcampo, Mireia, additional, Zulet, M. Ángeles, additional, Moreno-Rodríguez, Anaí, additional, Cueto-Galán, Raquel, additional, Vivancos-Aparicio, Diego, additional, Colom, Antoni, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Bernal-López, M Rosa, additional, Santos-Lozano, Jose Manuel, additional, Vázquez, Zenaida, additional, Gómez-Martínez, Carlos, additional, Ortega-Azorín, Carolina, additional, del Val, Jose Luís, additional, Abete, Itziar, additional, Goikoetxea-Bahon, Amaia, additional, Pascual, Elena, additional, Becerra-Tomás, Nerea, additional, Chillarón, Juan J., additional, and Sánchez-Villegas, Almudena, additional
Published: 2022
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