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Supplemental Material, sj-pdf-1-het-10.1177_09603271211045959 for Insulin-like growth factor reduced against decabromodiphenyl ether-209–induced neurodevelopmental toxicity in vivo and in vitro by Yuanxiang Yang, Qianyun He, Zhengyu Zhang, Chunli Qi, Lina Ding, Tingting Yuan, Yanhong Chen and Zhihua Li in Human & Experimental Toxicology

With the wide application of SRAM-based FPGA, the programmable resources of SRAM-based FPGA and its internal IP core are applied to the maximum extent. Owing to the negative correlation between the FPGA resource utilization and frequency, the FPGA frequency margin becomes a bottleneck that restricts reliable application of FPGA under extreme application conditions. The deviation of the manufacturing process leads to certain discreteness in the frequency after the FPGA chip is assembled and packaged, thus the devices with extremely low frequency shall be removed. In this regard, it is crucial to determine the frequency margin range of SRAM-based FPGA in order for the application reliability. In this paper, simulation and testing of the frequency limits of FPGA are conducted via LUT ring oscillator, carry chain ring oscillator and multiplier core ring oscillator, to analyze the simulation value and measured value, and the difference of the device under test from the products manufactured by Xilinx. The recommended standard for screening of the frequency margin of SRAM-based FPGA is also provided.

Miniature film fuse is a key component widely used in electronic systems for circuit protection. In order to meet the demand of high reliability application, higher requirements are raised on the miniature film fuse’s performance of reliability and application adaptability. Based on the characteristics of the fuse, and the actual application requirements of the circuit design, a key method for application verification is designed for the miniature film fuse, to evaluate its applicability and reliability in the high reliability engineering application, to serve as basis for its application in the electronic engineering.

Background. The prevalence of overweight/obesity in adults is raised to 39%, which is nearly tripled more than 1975. The alteration of the gut microbiome has been widely accepted as one of the main causal factors. To find an effective strategy for the prevention and treatment of overweight/obesity, a systematic review and meta-analysis were designed. Methods. In this study, we systematically reviewed the article published from January 2008 to July 2018 and conducted a meta-analysis to examine the effects of probiotics on body weight control, lipid profile, and glycemic control in healthy adults with overweight or obesity. The primary outcomes were body weight, body mass index (BMI), waist circumference, fat mass, fat percentages, plasma lipid profiles, and glucose metabolic parameters. Results. We systematically searched PubMed, Embase, and the Web of Science and identified 1248 articles, and 7 articles which were manually searched by the references of included studies and previously systematic reviews. Twelve randomized controlled trials (RCTs), including 821 participants, were included in the meta-analysis via full-text screening. Probiotics supplementation resulted in a statistical reduction in body weight (WMD [95% CI]; -0.55 [-0.91, -0.19] kg), BMI (WMD [95% CI]; -0.30 [-0.43, -0.18] kg m−2), waist circumference (WMD [95% CI]; -1.20 [-2.21, -0.19] cm), fat mass (WMD [95% CI]; -0.91 [-1.19, -0.63] kg), and fat percentage (WMD [95% CI]; -0.92 [-1.27, -0.56] %) compared with control groups. As expected, the metabolic parameters were improved significantly, with a pooled standardized mean difference in TC (SMD [95% CI]; -0.43 [-0.80, -0.07]), LDL-C (SMD [95% CI]; -0.41 [-0.77, -0.04]), FPG (SMD [95% CI]; -0.35 [-0.67, -0.02]), insulin (SMD [95% CI]; -0.44 [-0.84, -0.03]), and HOMA-IR (SMD [95% CI]; -0.51 [-0.96, -0.05]), respectively. The changes in TG (SMD [95% CI]; 0.14 [-0.23, 0.50]), HDL-C (SMD [95% CI]; -0.31 [-0.70, 0.07]), and HbA1c (SMD [95% CI]; -0.23 [-0.46, 0.01]) were not significant. Conclusion. This study suggests that the probiotics supplementation could potentially reduce the weight gain and improve some of the associated metabolic parameters, which may become an effective strategy for the prevention and treatment of obesity in adult individuals.