51. A discrete event system specification (DEVS)-based model of consanguinity
- Author
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Farah Mustafa, Muaz A. Niazi, Noreen Akhtar, and Amir Hussain
- Subjects
FOS: Computer and information sciences ,Male ,Complex systems ,Theoretical computer science ,DEVS ,J.3 ,Discrete Mathematics (cs.DM) ,J.4 ,Computer science ,Artificial intelligence Computer programs ,Quantitative Biology - Quantitative Methods ,Computer Science - Computers and Society ,Consanguinity ,Congenital disorder ,Marriage ,Consanguineous marriages ,Quantitative Methods (q-bio.QM) ,DEVS formalism ,education.field_of_study ,Applied Mathematics ,Computer Science - Social and Information Networks ,General Medicine ,Modeling and Simulation ,Female ,General Agricultural and Biological Sciences ,Simulation ,Algorithms ,Statistics and Probability ,I.2 ,C.4 ,B.1.2 ,Population ,Neural networks Computer science ,Cultural issues ,I.6 ,General Biochemistry, Genetics and Molecular Biology ,Congenital Abnormalities ,Computers and Society (cs.CY) ,Humans ,Computer Simulation ,Sex Distribution ,education ,Quantitative Biology - Populations and Evolution ,Population Growth ,Computational intelligence ,Social and Information Networks (cs.SI) ,General Immunology and Microbiology ,Models, Genetic ,I.2.0 ,Populations and Evolution (q-bio.PE) ,FOS: Biological sciences ,Computer Science - Discrete Mathematics - Abstract
Consanguinity or inter-cousin marriage is a phenomenon quite prevalent in certain regions around the globe. Consanguineous parents have a higher risk of having offspring with congenital disorders. It is difficult to model large scale consanguineous parental populations because of disparate cultural issues unique to regions and cultures across the globe. Although consanguinity, as a social problem has been studied previously, consanguinity from a biological perspective has yet to be modeled. Discrete Event System Specification (DEVS) formalism is a powerful modeling formalism for the study of intricate details of real-world complex systems. In this article, we develop a DEVS model to get an insight into the role of consanguineous marriages in the evolution of congenital disorders in a population. As proof-of-concept, we develop a consanguinity simulation model in Simio simulation software. Our results show the effectiveness of DEVS in the modeling of consanguinity effects in causing congenital defects., 41 pages, 10 figures
- Published
- 2010