Search

Your search keyword '"DEL PRATO, Stefano"' showing total 1,623 results
Start Over Author "DEL PRATO, Stefano"
1,623 results on '"DEL PRATO, Stefano"'

57. Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery

Author

Rubino, Francesco, Cohen, Ricardo V, Mingrone, Geltrude, le Roux, Carel W, Mechanick, Jeffrey I, Arterburn, David E, Vidal, Josep, Alberti, George, Amiel, Stephanie A, Batterham, Rachel L, Bornstein, Stefan, Chamseddine, Ghassan, Del Prato, Stefano, Dixon, John B, Eckel, Robert H, Hopkins, David, McGowan, Barbara M, Pan, An, Patel, Ameet, Pattou, François, Schauer, Philip R, Zimmet, Paul Z, and Cummings, David E

Published
2020
Full Text
View/download PDF

58. Review of methods for detecting glycemic disorders

Author

Bergman, Michael, Abdul-Ghani, Muhammad, DeFronzo, Ralph A., Manco, Melania, Sesti, Giorgio, Fiorentino, Teresa Vanessa, Ceriello, Antonio, Rhee, Mary, Phillips, Lawrence S., Chung, Stephanie, Cravalho, Celeste, Jagannathan, Ram, Monnier, Louis, Colette, Claude, Owens, David, Bianchi, Cristina, del Prato, Stefano, Monteiro, Mariana P., Neves, João Sérgio, Medina, Jose Luiz, Macedo, Maria Paula, Ribeiro, Rogério Tavares, Filipe Raposo, João, Dorcely, Brenda, Ibrahim, Nouran, and Buysschaert, Martin

Published
2020
Full Text
View/download PDF

61. Effects of albiglutide on myocardial infarction and ischaemic heart disease outcomes in patients with type 2 diabetes and cardiovascular disease in the Harmony Outcomes trial

Author

Krychtiuk, Konstantin A, primary, Marquis-Gravel, Guillaume, additional, Murphy, Shannon, additional, Alexander, Karen P, additional, Chiswell, Karen, additional, Green, Jennifer B, additional, Leiter, Lawrence A, additional, Lopes, Renato D, additional, Del Prato, Stefano, additional, Jones, William Schuyler, additional, McMurray, John J V, additional, Hernandez, Adrian F, additional, and Granger, Christopher B, additional

Published
2024
Full Text
View/download PDF

62. Cardiovascular and renal outcomes with varying degrees of kidney disease in high‐risk people with type 2 diabetes: An epidemiological analysis of data from the AMPLITUDE‐O trial

Author

Gerstein, Hertzel C., primary, Mian, Rajibul, additional, Ramasundarahettige, Chinthanie, additional, Branch, Kelley R. H., additional, Del Prato, Stefano, additional, Lam, Carolyn S. P., additional, Lopes, Renato D., additional, Pratley, Richard, additional, Rosenstock, Julio, additional, and Sattar, Naveed, additional

Published
2023
Full Text
View/download PDF

65. Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy

Author

Daniele, Giuseppe, Solis-Herrera, Carolina, Dardano, Angela, Mari, Andrea, Tura, Andrea, Giusti, Laura, Kurumthodathu, Jancy J., Campi, Beatrice, Saba, Alessandro, Bianchi, Anna Maria, Tregnaghi, Carla, Egidi, Maria Francesca, Abdul-Ghani, Muhammad, DeFronzo, Ralph, and Del Prato, Stefano

Published
2020
Full Text
View/download PDF

72. Treatment with Oral Drugs

Author

Bianchi, Cristina, Daniele, Giuseppe, Dardano, Angela, Del Prato, Stefano, Lenzi, Andrea, Series Editor, Jannini, Emmanuele A., Series Editor, Bonora, Enzo, editor, and DeFronzo, Ralph A., editor

Published
2018
Full Text
View/download PDF

74. Cardiovascular and renal outcomes with varying degrees of kidney disease in high‐risk people with type 2 diabetes: An epidemiological analysis of data from the AMPLITUDE‐O trial.

Author

Gerstein, Hertzel C., Mian, Rajibul, Ramasundarahettige, Chinthanie, Branch, Kelley R. H., Del Prato, Stefano, Lam, Carolyn S. P., Lopes, Renato D., Pratley, Richard, Rosenstock, Julio, and Sattar, Naveed

Subjects
TYPE 2 diabetes, KIDNEY diseases, MAJOR adverse cardiovascular events, DATA analysis, PEOPLE with diabetes
Abstract

Aims: To estimate the incidence of a major adverse cardiovascular event (MACE) and a composite kidney outcome across estimated glomerular filtration rate (eGFR) and urine albumin‐to‐creatinine ratio (UACR) levels, and to determine whether efpeglenatide's effect varies with these indices. Materials and Methods: AMPLITUDE‐O trial data were used to estimate the relationship of eGFR, UACR, and Kidney Disease Improving Global Outcomes (KDIGO) category to the hazard of MACE and the kidney composite. Interactions on these outcomes between eGFR and the UACR, and between each of these variables and efpeglenatide were also assessed. Results: Baseline eGFR and UACR were available for 3983 participants (mean age 64.5 years). During a median follow‐up of 1.8 years, the hazards of MACE and the kidney composite for the lowest versus highest eGFR third were 1.6 (95% confidence interval [CI] 1.2, 2.2) and 2.3 (95% CI 1.9, 2.8), respectively. The hazards for the highest versus the lowest UACR third were 2.3 (95% CI 1.8, 3.1) and 18.0 (95% CI 12.7, 25.5), respectively, and for the high‐ versus low‐risk KDIGO categories the hazards were 2.4 (95% CI 1.8, 3.1) and 16.0 (95% CI 11.6, 22.0), respectively. eGFR and UACR were independent determinants of both outcomes, but negatively interacted with each other for the kidney outcome. Efpeglenatide's effect on both outcomes did not vary with any kidney disease measure (all interaction p values ≥0.26). Conclusions: In high‐risk people with diabetes, eGFR, UACR, and KDIGO category have different relationships to incident cardiovascular and kidney outcomes. The beneficial effect of efpeglenatide on these outcomes is independent of kidney‐related risk category. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

75. Cardio‐renal‐metabolic disease in primary care setting.

Author

Ibrahim, Mahmoud, Ba‐Essa, Ebtesam M., Baker, Jason, Cahn, Avivit, Ceriello, Antonio, Cosentino, Francesco, Davies, Melanie J., Eckel, Robert H., Van Gaal, Luc, Gaede, Peter, Handelsman, Yehuda, Klein, Samuel, Leslie, Richard David, Pozzilli, Paolo, Del Prato, Stefano, Prattichizzo, Francesco, Schnell, Oliver, Seferovic, Petar M., Standl, Eberhard, and Thomas, Abraham

Subjects
CONTINUOUS glucose monitoring, PRIMARY care, TYPE 2 diabetes, HYPOGLYCEMIA, HEART diseases
Abstract

In the primary care setting providers have more tools available than ever before to impact positively obesity, diabetes, and their complications, such as renal and cardiac diseases. It is important to recognise what is available for treatment taking into account diabetes heterogeneity. For those who develop type 2 diabetes (T2DM), effective treatments are available that for the first time have shown a benefit in reducing mortality and macrovascular complications, in addition to the well‐established benefits of glucose control in reducing microvascular complications. Some of the newer medications for treating hyperglycaemia have also a positive impact in reducing heart failure (HF). Technological advances have also contributed to improving the quality of care in patients with diabetes. The use of technology, such as continuous glucose monitoring systems (CGM), has improved significantly glucose and glycated haemoglobin A1c (HbA1c) values, while limiting the frequency of hypoglycaemia. Other technological support derives from the use of predictive algorithms that need to be refined to help predict those subjects who are at great risk of developing the disease and/or its complications, or who may require care by other specialists. In this review we also provide recommendations for the optimal use of the new medications; sodium‐glucose co‐transporter‐2 inhibitors (SGLT2i) and Glucagon‐like peptide‐receptor agonists 1 (GLP1RA) in the primary care setting considering the relevance of these drugs for the management of T2DM also in its early stage. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

77. Practical Algorithms for Early Diagnosis of Heart Failure and Heart Stress using NT‐proBNP: A Clinical Consensus Statement from the Heart Failure Association of the ESC

Author

Bayes‐Genis, Antoni, primary, Doherty, Kieran F, additional, Petrie, Mark C, additional, Januzzi, James L, additional, Mueller, Christian, additional, Andreson, Lisa, additional, Bozkurt, Biykem, additional, Butler, Javed, additional, Chioncel, Ovidiu, additional, Cleland, John GF, additional, Christodorescu, Ruxandra, additional, Del Prato, Stefano, additional, Gustafsson, Finn, additional, Lam, Carolyn S.P., additional, Moura, Brenda, additional, Pop‐Busui, Rodica, additional, Seferovic, Petar, additional, Volterrani, Maurizio, additional, Vaduganathan, Muthiah, additional, Metra, Marco, additional, and Rosano, Giuseppe, additional

Published
2023
Full Text
View/download PDF

82. Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study

Author

Vitale, Marilena, Vaccaro, Olga, Masulli, Maria, Bonora, Enzo, Del Prato, Stefano, Giorda, Carlo B., Nicolucci, Antonio, Squatrito, Sebastiano, Auciello, Stefania, Babini, Anna C., Bani, Laura, Buzzetti, Raffaella, Cannarsa, Emanuela, Cignarelli, Mauro, Cigolini, Massimo, Clemente, Gennaro, Cocozza, Sara, Corsi, Laura, D'Angelo, Federica, Dall'Aglio, Elisabetta, Di Cianni, Graziano, Fontana, Lucia, Gregori, Giovanna, Grioni, Sara, Giordano, Carla, Iannarelli, Rossella, Iovine, Ciro, Lapolla, Annunziata, Lauro, Davide, Laviola, Luigi, Mazzucchelli, Chiara, Signorini, Stefano, Tonutti, Laura, Trevisan, Roberto, Zamboni, Chiara, Riccardi, Gabriele, and Rivellese, Angela A.

Published
2017
Full Text
View/download PDF

83. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Author

Vaccaro, Olga, Masulli, Maria, Nicolucci, Antonio, Maggioni, Aldo Pietro, Sesti, Giorgio, Mocarelli, Paolo, Lucisano, Giuseppe, Sacco, Michele, Signorini, Stefano, Cappellini, Fabrizio, Riccardi, Gabriele, Boemi, Massimo, D'Angelo, Federica, Giansanti, Roberto, Tanase, Laura, Lanari, Luigi, Testa, Ivano, Ricci, Lucia, Pancani, Francesca, Ranchelli, Anna, Vagheggi, Paolo, Scatona, Alessia, Fontana, Lucia, Giorgino, Francesco, Laviola, Luigi, Tarantino, Lucia, Ippolito, Claudia, Gigantelli, Vittoria, Manicone, Mariangela, Conte, Eleonora, Trevisan, Roberto, Scaranna, Cristiana, Rota, Rossella, Corsi, Anna, Dodesini, Alessandro R., Reggiani, Giulio Marchesini, Montesi, Luca, Mazzella, Natalia, Forlani, Gabriele, Caselli, Chiara, Di Luzio, Raffaella, Mazzotti, Arianna, Aiello, Antimo, Barrea, Angelina, Musto, Antonio, D'Amico, Fiorentina, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Trowpea, Vanessa, Sparti, Maria, Italia, Salvatore, Lisi, Enrico, Grasso, Giuseppe, Pezzino, Vincenzo, Insalaco, Federica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, De Franceschi, Maria Serena, Santini, Costanza, Calbucci, Giovanni, Ripani, Raffaella, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Giorda, Carlo B., Romeo, Francesco, Lesina, Annalisa, Comoglio, Marco, Bonetto, Caterina, Robusto, Anna, Nada, Elisa, Asprino, Vincenzo, Cetraro, Rosa, Impieri, Michelina, Lucchese, Giuseppe, Donnarumma, Giovanna, Tizio, Biagio, Clemente, Gennaro, Lenza, Lazzaro, Paraggio, Pia, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Scalambra, Egle, Mannucci, Edoardo, Lamanna, Caterina, Cignarelli, Mauro, Macchia, Olga La, Fariello, Stefania, Sorrentino, Maria Rosaria, Franzetti, Ivano, Radin, Raffaella, Cordera, Renzo, Annunziata, Francesca, Bonabello, Laura Affinito, Durante, Arianna, Dolcino, Mara, Gallo, Fiorenza, Mazzucchelli, Chiara, Aleo, Anna, Melga, Pierluigi, Briatore, Lucia, Maggi, Davide, Storace, Daniela, Cecoli, Francesca, Antenucci, Daniela, D'Ugo, Ercole, Pupillo, Mario, Baldassarre, Maria Pompea Antonia, Salvati, Filippo, Minnucci, Anita, De Luca, Angelo, Zugaro, Antonella, Santarelli, Livia, Bosco, Angela, Petrella, Vittorio, La Verghetta, Grazia Giovanna, Iannarelli, Rossella, De Gregorio, Antonella, D'Andrea, Settimio, Giuliani, Anna Elisa, Polidoro, w Lorella, Sperandio, Alessandra, Sciarretta, Filomena, Pezzella, Alfonso, Buzzetti, Raffaella, Carlone, Angela, Potenziani, Stella, Venditti, Chiara, Foffi, Chiara, Carbone, Salvatore, Cipolloni, Laura, Moretti, Chiara, Leto, Gaetano, Serra, Rosalia, Petrachi, Francesca, Romano, Isabella, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Goretti, Chiara, Sannino, Claudia, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Mori, Mary L., Baccetti, Fabio, Del Freo, Maria, Di Benedetto, Antonino, Cucinotta, Domenico, Giunta, Loretta, Ruffo, Maria Concetta, Cannizzaro, Desiree, Pintaudi, Basilio, Perrone, Giovanni, Pata, Pietro, Ragonese, Francesco, Lettina, Gabriele, Mancuso, Teresa, Coppolino, Aldo, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Lucotti, Pietro, Setola, Manuela, Crippa, Giulia Valentina, Loi, Cinzia, Oldani, Matteo, Bottalico, Maria Luisa, Pellegata, Beatrice, Bonomo, Matteo, Menicatti, Laura Silvia Maria, Resi, Veronica, Bertuzzi, Federico, Disoteo, Eugenia Olga, Pizzi, Gianluigi, Rivellese, Angela Albarosa, Annuzzi, Giovanni, Capaldo, Brunella, Nappo, Rossella, Auciello, Stefania Michela, Turco, Anna Amelia, Costagliola, Lucia, Iovine, Ciro, Corte, Giuseppina Della, Vallefuoco, Pasquale, Nappi, Francesca, Vitale, Marilena, Cocozza, Sara, Ciano, Ornella, Massimino, Elena, Garofalo, Nadia, Avogaro, Angelo, Vedovato, Monica, Guarneri, Gabriella, Lapolla, Annunziata, Fedele, Domenico, Sartore, Giovanni, Chilelli, Nino Cristiano, Burlina, Silvia, Bonsembiante, Barbara, Giordano, Carla, Galluzzo, Aldo, Torregrossa, Vittoria, Dall'Aglio, Elisabetta, Mancastroppa, Giovanni, Arsenio, Leone, Cioni, Federico, Caronna, Silvana, Papi, Matteo, Babini, Massimiliano, Perriello, Gabriele, Santeusanio, Fausto, Calagreti, Gioia, Timi, Alessia, Tantucci, Alice, Marino, Cecilia, Consoli, Agostino, Ginestra, Federica, Di Biagio, Rosamaria, Taraborelli, Merilda, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Politi, Konstantina Savina, Penno, Giuseppe, Zavaroni, Donatella, Livraga, Stefania, Calzoni, Fabio, Mancastroppa, Giovanni Luigi Francesco, Anichini, Roberto, Corsini, Elisa, Tedeschi, Anna, Gaglianò, Maria Sole, Ippolito, Giulio, Salutini, Elisabetta, Citro, Giuseppe, Cervellino, Francesco, Natale, Maria, Salvatore, Vita, Zampino, Armando, Sinisi, Rosa, Calabrese, Maria, Arcangeli, Adolfo, Zogheri, Alessia, Guizzotti, Sandra, Longo, Rossella, Di Bartolo, Paolo, Pellicano, Francesca, Scolozzi, Patrizia, Termine, Simona, Luberto, Alessandra, Ballardini, Giorgio, Babini, Anna Carla, Trojani, Cristina, Mazzuca, Paolo, Bruglia, Matteo, Ciamei, Monica, Genghini, Silvia, Zannoni, Chiara, Pugliese, Giuseppe, Vitale, Martina, Rangel, Graziela, Salvi, Laura, Zappaterreno, Alessandra, Cordone, Samantha, Simonelli, Paola, Meggiorini, Marilla, Frasheri, Aurora, Di Pippo, Clelia, Maglio, Cristina, Mazzitelli, Giulia, Lauro, Davide, Rinaldi, Maria Elena, Galli, Angelica, Romano, Maria, D'Angelo, Paola, Leotta, Sergio, Suraci, Concetta, De Cosmo, Salvatore, Bacci, Simonetta, Palena, Antonio Pio, Genovese, Stefano, Mancino, Monica, Rondinelli, Maurizio, Capone, Filippo, Calabretto, Elisabetta, Bulgheroni, Monica, Bucciarelli, Loredana, Dotta, Francesco, Ceccarelli, Elena, Fondelli, Cecilia, Santacroce, Clorinda, Guarino, Elisa, Nigi, Laura, Lalli, Carlo, Di Vizia, Giovanni, Scarponi, Maura, Montani, Valeria, Di Bernardino, Paolo, Romagni, Paola, Dolcetti, Katia, Cannarsa, Emanuela, Forte, Elisa, Tamburo, Lucilla, Fornengo, Paolo, Perin, Paolo Cavallo, Prinzis, Tania, Gruden, Gabriella, Bruno, Graziella, Zucco, Chiara, Perotta, Massimo, Marena, Saverio, Monsignore, Simona, Panero, Francesco, Ponzi, Fulvia, Bossi, Antonio Carlo, Carpinteri, Rita, Casagrande, Maria Linda, Coletti, Maria Francesca, Balini, Annalisa, Filopanti, Marcello, Madaschi, Sara, Pulcina, Anna, Grimaldi, Franco, Tonutti, Laura, Venturini, Giorgio, Agus, Sandra, Pagnutti, Stefania, Guidotti, Francesca, Cavarape, Alessandro, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Fainelli, Giulia, Tomasetto, Elena, Zoppini, Giacomo, Galletti, Anna, Perrone, Dominica, Capra, Claudio, Bianchini, Francesca, Ceseri, Martina, Di Nardo, Barbara, Sasso, Elisa, Bartolomei, Barbara, Suliman, Irina, Fabbri, Gianna, Romano, Geremia, Maturo, Nicola, Nunziata, Giuseppe, Capobianco, Giuseppe, De Simone, Giuseppina, Villa, Valeria, Rota, Giuseppe, Pentangelo, Carmine, Carbonara, Ornella, Caiazzo, Gennaro, Cutolo, Michele, Sorrentino, Tommasina, Mastrilli, Valeria, Amelia, Umberto, Masi, Stefano, Corigliano, Gerardo, Gaeta, Iole, Armentano, Vincenzo, Calatola, Pasqualino, Capuano, Gelsomina, Angiulli, Bruno, Auletta, Pasquale, Petraroli, Ettore, Iodice, Cinzia E., Agrusta, Mariano, Maggioni, Aldo P, Rivellese, Angela A, Giorda, Carlo B, La Macchia, Olga, Bossi, Antonio C, and di Bartolo, Paolo

Published
2017
Full Text
View/download PDF

90. EFFECTS OF ALBIGLUTIDE ON TYPES AND NUMBERS OF MYOCARDIAL INFARCTION IN PATIENTS WITH TYPE 2 DIABETES AND CARDIOVASCULAR DISEASE IN THE HARMONY OUTCOMES TRIAL

Author

Krychtiuk, Konstantin, primary, Marquis-Gravel, Guillaume, additional, Murphy, Shannon, additional, Chiswell, Karen E., additional, Green, Jennifer, additional, Del Prato, Stefano, additional, Jones, Schuyler, additional, Hernandez, Adrian F., additional, McMurray, John J.V., additional, and Granger, Christopher B., additional

Published
2023
Full Text
View/download PDF

91. Diabetes registries and high-quality diabetes care

Author

Khunti, Kamlesh, primary, Mathieu, Chantal, additional, Torbeyns, Bart, additional, Del Prato, Stefano, additional, Heine, Robert, additional, Colhoun, Helen, additional, Danne, Thomas, additional, Due-Christensen, Mette, additional, Eeg-Olofsson, Katarina, additional, Fagherazzi, Guy, additional, Haustein, Robert, additional, Klok, Rogier, additional, Levrat-Guillen, Fleur, additional, Massi Benedetti, Massimo, additional, Mata, Manel, additional, Pall, Jaivir, additional, Soderberg, Jeannette, additional, Vedin, Ola, additional, and Wilson, Petra, additional

Published
2023
Full Text
View/download PDF

92. Practical algorithms for early diagnosis of heart failure and heart stress using NT-proBNP:A clinical consensus statement from the Heart Failure Association of the ESC

Author

Bayes-Genis, Antoni, Docherty, Kieran F., Petrie, Mark C., Januzzi, James L., Mueller, Christian, Anderson, Lisa, Bozkurt, Biykem, Butler, Javed, Chioncel, Ovidiu, Cleland, John G.F., Christodorescu, Ruxandra, Del Prato, Stefano, Gustafsson, Finn, Lam, Carolyn S.P., Moura, Brenda, Pop-Busui, Rodica, Seferovic, Petar, Volterrani, Maurizio, Vaduganathan, Muthiah, Metra, Marco, Rosano, Giuseppe, Bayes-Genis, Antoni, Docherty, Kieran F., Petrie, Mark C., Januzzi, James L., Mueller, Christian, Anderson, Lisa, Bozkurt, Biykem, Butler, Javed, Chioncel, Ovidiu, Cleland, John G.F., Christodorescu, Ruxandra, Del Prato, Stefano, Gustafsson, Finn, Lam, Carolyn S.P., Moura, Brenda, Pop-Busui, Rodica, Seferovic, Petar, Volterrani, Maurizio, Vaduganathan, Muthiah, Metra, Marco, and Rosano, Giuseppe

Abstract

Diagnosing heart failure is often difficult due to the non-specific nature of symptoms, which can be caused by a range of medical conditions. Natriuretic peptides (NPs) have been recognized as important biomarkers for diagnosing heart failure. This document from the Heart Failure Association examines the practical uses of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in various clinical scenarios. The concentrations of NT-proBNP vary according to the patient profile and the clinical scenario, therefore values should be interpreted with caution to ensure appropriate diagnosis. Validated cut-points are provided to rule in or rule out acute heart failure in the emergency department and to diagnose de novo heart failure in the outpatient setting. We also coin the concept of ‘heart stress’ when NT-proBNP levels are elevated in an asymptomatic patient with risk factors for heart failure (i.e. diabetes, hypertension, coronary artery disease), underlying the development of cardiac dysfunction and further increased risk. We propose a simple acronym for healthcare professionals and patients, FIND-HF, which serves as a prompt to consider heart failure: Fatigue, Increased water accumulation, Natriuretic peptide testing, and Dyspnoea. Use of this acronym would enable the early diagnosis of heart failure. Overall, understanding and utilizing NT-proBNP levels will lead to earlier and more accurate diagnoses of heart failure ultimately improving patient outcomes and reducing healthcare costs., Diagnosing heart failure is often difficult due to the non-specific nature of symptoms, which can be caused by a range of medical conditions. Natriuretic peptides (NPs) have been recognized as important biomarkers for diagnosing heart failure. This document from the Heart Failure Association examines the practical uses of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in various clinical scenarios. The concentrations of NT-proBNP vary according to the patient profile and the clinical scenario, therefore values should be interpreted with caution to ensure appropriate diagnosis. Validated cut-points are provided to rule in or rule out acute heart failure in the emergency department and to diagnose de novo heart failure in the outpatient setting. We also coin the concept of ‘heart stress’ when NT-proBNP levels are elevated in an asymptomatic patient with risk factors for heart failure (i.e. diabetes, hypertension, coronary artery disease), underlying the development of cardiac dysfunction and further increased risk. We propose a simple acronym for healthcare professionals and patients, FIND-HF, which serves as a prompt to consider heart failure: Fatigue, Increased water accumulation, Natriuretic peptide testing, and Dyspnoea. Use of this acronym would enable the early diagnosis of heart failure. Overall, understanding and utilizing NT-proBNP levels will lead to earlier and more accurate diagnoses of heart failure ultimately improving patient outcomes and reducing healthcare costs.

Published
2023

96. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

Author

DAddio, Francesca, Maestroni, Anna, Assi, Emma, Ben Nasr, Moufida, Amabile, Giovanni, Usuelli, Vera, Loretelli, Cristian, Bertuzzi, Federico, Antonioli, Barbara, Cardarelli, Francesco, El Essawy, Basset, Solini, Anna, Gerling, Ivan C., Bianchi, Cristina, Becchi, Gabriella, Mazzucchelli, Serena, Corradi, Domenico, Fadini, Gian Paolo, Foschi, Diego, Markmann, James F., Orsi, Emanuela, Skrha, Jan, Camboni, Maria Gabriella, Abdi, Reza, Shapiro, A. M. James, Folli, Franco, Ludvigsson, Johnny, Del Prato, Stefano, Zuccotti, Gianvincenzo, Fiorina, Paolo, D'Addio, F., Maestroni, A., Assi, E., Ben Nasr, M., Amabile, G., Usuelli, V., Loretelli, C., Bertuzzi, F., Antonioli, B., Cardarelli, F., El Essawy, B., Solini, A., Gerling, I. C., Bianchi, C., Becchi, G., Mazzucchelli, S., Corradi, D., Fadini, G. P., Foschi, D., Markmann, J. F., Orsi, E., Skrha, J., Camboni, M. G., Abdi, R., James Shapiro, A. M., Folli, F., Ludvigsson, J., Del Prato, S., Zuccotti, G., and Fiorina, P.

Subjects
Male, Cell- och molekylärbiologi, Inbred C57BL, cells, cultured, Transgenic, Mice, Mice, Inbred NOD, Insulin-Secreting Cells, middle aged, Homeostasis, animal, membrane protein, Cells, Cultured, Mice, Knockout, Cultured, Reverse Transcriptase Polymerase Chain Reaction, adult, gene expression regulation, Middle Aged, reverse transcriptase polymerase chain reaction, diabetes mellitus, type 1, female, diabetes mellitus, type 2, Female, immunoblotting, signal transduction, Type 2, Type 1, Signal Transduction, Adult, mice, inbred C57BL, Cells, Knockout, Science, mice, knockout, Immunoblotting, Mice, Transgenic, Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Insulin-Like Growth Factor Binding Protein 3, Membrane Proteins, Mice, Inbred C57BL, Gene Expression Regulation, male, insulin-secreting cell, Diabetes Mellitus, human, mice, inbred NOD, mice, transgenic, homeostasi, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Inbred NOD, insulin-like growth factor binding protein 3, Cell and Molecular Biology
Abstract

In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes. Loss of pancreatic beta cells is a central feature of type 1 (T1D) and type 2 (T2D) diabetes, but a therapeutic strategy to preserve beta cell mass remains to be established. Here we show that the death receptor TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction. Increased peripheral IGFBP3 was observed in established and at-risk T1D/T2D patients and was confirmed in T1D/T2D preclinical models, suggesting that dysfunctional IGFBP3/TMEM219 signaling is associated with abnormalities in beta cells homeostasis. In vitro and in vivo short-term IGFBP3/TMEM219 inhibition and TMEM219 genetic ablation preserved beta cells and prevented/delayed diabetes onset, while long-term IGFBP3/TMEM219 blockade allowed for beta cell expansion. Interestingly, in several patients cohorts restoration of appropriate IGFBP3 levels was associated with improved beta cell function. The IGFBP3/TMEM219 pathway is thus shown to be a physiological regulator of beta cell homeostasis and is also demonstrated to be disrupted in T1D/T2D. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes. Funding Agencies|SID Lombardia Grant; EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research; Italian Ministry of HealthMinistry of Health, Italy [RF-2016-02362512]; Universita di Milano; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [DK104155]; Juvenile Diabetes Research FoundationJuvenile Diabetes Research Foundation; Enthera S.r.l.

Published
2022

97. Cover Image

Author

Garofolo, Monia, primary, Napoli, Vinicio, additional, Lucchesi, Daniela, additional, Accogli, Sandra, additional, Mazzeo, Maria Letizia, additional, Rossi, Piercarlo, additional, Neri, Emanuele, additional, Del Prato, Stefano, additional, and Penno, Giuseppe, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results