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336 results on '"DE NOVELLIS, V."'

51. Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice

Author

Guida, F., primary, Luongo, L., additional, Marmo, F., additional, Romano, R., additional, Iannotta, M., additional, Napolitano, F., additional, Belardo, C., additional, Marabese, I, additional, D’Aniello, A., additional, De Gregorio, D., additional, Rossi, F., additional, Piscitelli, F., additional, Lattanzi, R., additional, de Bartolomeis, A., additional, Usiello, A., additional, Di Marzo, V., additional, de Novellis, V., additional, and Maione, S, additional

Published
2015
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57. The prokineticin receptor agonist Bv8 increases GABA release in the periaqueductal grey and modifies RVM cell activities and thermoceptive reflexes in the rat

Author

DE NOVELLIS, V., Negri, Lucia, Lattanzi, Roberta, Rossi, F., Palazzo, E., Marabese, I., Giannini, Elisa, Vita, D., Melchiorri, Pietro, and Maione, S.

Subjects
Male, Tail, Microdialysis, Action Potentials, ROSTRAL VENTROMEDIAL MEDULLA, In Vitro Techniques, Gastrointestinal Hormones, PROTEIN-COUPLED RECEPTORS, Reflex, ENDOTHELIAL GROWTH-FACTOR, NUCLEUS RAPHE MAGNUS, NEUROPATHIC PAIN, Reaction Time, Animals, Periaqueductal Gray, Rats, Wistar, In Situ Hybridization, gamma-Aminobutyric Acid, Pain Measurement, Neurons, Medulla Oblongata, Dose-Response Relationship, Drug, Neuropeptides, Rats, Hyperalgesia, Autoradiography
Abstract

The prokineticin Bv8, a small protein secreted by the skin of the Bombina variegata frog, is a potent agonist of both the identified prokineticin receptors, the G-protein-coupled PK-R1 and PK-R2. We found in this study that intraperiaqueductal grey (PAG) Bv8, 100 and 200 pmol per rat, exerted a pronociceptive action and caused opposite effects on the ongoing rostral ventromedial medulla (RVM) On- and Off-cell activities in rats. Bv8 increased and decreased the ongoing activity of RVM On and Off cells, respectively. Bv8 decreased tail flick latency and increased the pause and shortened the onset of the Off-cell pause. Bv8 did not change either the tail flick-induced On-cell burst of activity or the onset of On-cell peak firing. Microdialysis analysis, applied in combination with the plantar test, showed that intra-PAG perfusion with Bv8 (0.25 and 0.5 pm) increased GABA, but not glutamate, extracellular levels, and decreased thermoceptive thresholds. These findings show that stimulation of PAG PK-Rs might worsen pain perception and this effect is consistent with both RVM On- and Off-cell ongoing and tail flick-related activities, as well as with the increase induced by Bv8 in PAG GABA levels.

Published
2007

58. Periaqueductal Gray Metabotropic Glutamate Receptor Subtype 7 and 8 Mediate Opposite Effects on Amino Acid Release, Rostral Ventromedial Medulla Cell Activities, and Thermal Nociception

Author

Marabese I.(1), Rossi F. (1), Palazzo E.(1), de Novellis V. (1), Starowicz K.(2), Cristino L. (3), Vita D. (1), Gatta L.(1), Guida F.(1), Di Marzo V.(2), and Maione S. (1,2)

Subjects
nervous system
Abstract

The current study has investigated the involvement of periaqueductal gray (PAG) metabotropic glutamate subtype 7 and 8 receptors (mGluR7 and mGluR8) in modulating rostral ventromedial medulla (RVM) ongoing and tail flick–related ON and OFF cell activities. Our study has also investigated the role of PAG mGluR7 on thermoceptive threshold and PAG glutamate and GABA release. Intra-ventrolateral PAG (S)-3,4-dicarboxyphenylglycine [(S)-3,4-DCPG (2 and 4 nmol/rat)] or N,NI-dibenzhydrylethane-1,2-diamin dihydrochloride (AMN082, (1 and 2 nmol/rat), selective mGluR8 and mGluR7 agonists, respectively, caused opposite effects on the ongoing RVM ON and OFF cell activities. Tail flick latency was increased or decreased by (S)-3,4-DCPG or AMN082 (2 nmol/rat), respectively. (S)-3,4-DCPG reduced the pause and delayed the onset of the OFF cell pause. Conversely, AMN082 increased the pause and shortened the onset of OFF cell pause. (S)-3,4-DCPG or AMN082 did not change the tail flick-induced onset of ON-cell peak firing. The tail flick latency and its related electrophysiological effects induced by (S)-3,4-DCPG or AMN082 were prevented by (RS)--methylserine-o-phosphate (100 nmol/rat), a group III mGluR antagonist. Intra-ventrolateral PAG perfusion with AMN082 (10 and 25 µM), decreased thermoceptive thresholds and glutamate extracellular levels. A decrease in GABA release was also observed. These results show that stimulation of PAG mGluR8 or mGluR7 could either relieve or worsen pain perception. The opposite effects on pain behavior correlate with the opposite roles played by mGluR7 and mGluR8 on glutamate and GABA release and the ongoing and tail flick-related activities of the RVM ON and OFF cells.

Published
2007

59. Method for treating pain

Author

Di Marzo V, De Petrocellis L, Maione S, De Novellis V, and Woodward D

Published
2007

64. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature

Author

Luongo, L, Costa, B, D'Agostino, B, Guida, F, Comelli, F, Gatta, L, Matteis, M, Sullo, N, De Petrocellis, L, de Novellis, V, Maione, S, Di Marzo, V, COSTA, BARBARA SIMONA, COMELLI, FRANCESCA, Di Marzo, V., Luongo, L, Costa, B, D'Agostino, B, Guida, F, Comelli, F, Gatta, L, Matteis, M, Sullo, N, De Petrocellis, L, de Novellis, V, Maione, S, Di Marzo, V, COSTA, BARBARA SIMONA, COMELLI, FRANCESCA, and Di Marzo, V.

Abstract

N-Palmitoyl-vanillamide (palvanil) is a non-pungent capsaicinoid, found in low amounts in Capsicum and shown to rapidly desensitize transient receptor potential vanilloid type-1 (TRPV1) channels to the action of capsaicin and to exert analgesic effects after local administration. We have investigated here if systemic administration of palvanil to mice causes two typical adverse events of TRPV1 agonists, i.e. profound changes in body temperature and bronchoconstriction, and if it can still produce effective inhibition of inflammatory and chronic pain in different experimental models. Varying doses of palvanil were tested subcutaneously and acutely on body temperature in vivo or, or as a bolus, on bronchopulmunary function ex vivo, in comparison with capsaicin. Intraperitoneal palvanil was also tested against formalin-induced nocifensive behavior and carrageenan-induced oedema and thermal hyperalgesia, acutely, and against mechanical allodynia and thermal hyperalgesia in mice with spared nerve injury (SNI) of the sciatic nerve, after repeated administration over 7 days from SNI. Palvanil, at therapeutically relevant doses, produced significantly less hypothermia and bronchoconstriction than capsaicin. Palvanil (0.5-2.5 mg/kg) abolished formalin-induced nocifensive behavior and strongly attenuated SNI-induced mechanical allodynia and thermal hyperalgesia and carrageenan-induced oedema and thermal hyperalgesia. Systemic administration of the non-pungent capsaicinoid, palvanil, produces, at least in mice, much less of those side effects typical of TRPV1 agonists (hypothermia and bronchoconstriction), whilst being very effective at reducing pain and oedema. Thus, palvanil might be developed further as a novel pharmacological treatment for chronic abnormal pain

Published
2012

65. The A1 adenosine receptor as a new player in microglia physiology

Author

Luongo, L., primary, Guida, F., additional, Imperatore, R., additional, Napolitano, F., additional, Gatta, L., additional, Cristino, L., additional, Giordano, C., additional, Siniscalco, D., additional, Di Marzo, V., additional, Bellini, G., additional, Petrelli, R., additional, Cappellacci, L., additional, Usiello, A., additional, de Novellis, V., additional, Rossi, F., additional, and Maione, S., additional

Published
2013
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66. Ballistics shower during plinian scenario at Vesuvius

Author

Dobran, F., De Novellis, V., Luongo, G., Dobran, F., De Novellis, V., and Luongo, G.

Abstract

The distribution of pyroclasts from 79 A.D. eruption of Vesuvius is analysed to assess the ejection velocities of ballistic particles pertaining to the white and gray eruption phases. This distribution is related to the energy of the eruptive mixture and conditions of the atmosphere during the eruption. Ballistic debris is common in the deposits, and within the sampled area (3–14 km S-SE from the vent) the ejected blocks are scattered throughout the fine-grained pumice fall. We measured about 300 ballistic blocks with diameters between 0.07 and 1 m. Some fragments as large as 0.3 m are located at 9 km from the vent, which probably represents the ballistic limit of such fragments. By using a ballistic model for large blocks permitted an assessment of their initial velocities which range from 170 to 2300m/s, and since some of these velocities exceed the maximum observed velocities of plinian eruptions we conclude that the ballistic model is deficient. The trajectories of smaller blocks (0.1

Published
2006

72. 5: Ballistics Shower During Plinian Scenario at Vesuvius: 5.4. DISCUSSION.

Author

De Novellis, V. and Luongo, G.

Abstract

Section 4 of the Chapter 5 of the book "Vesuvius: Education, Security and Prosperity" is presented. It describes the size of the clasts data collected in the field within 3-14 kilometer from the vent. It shows the results of the work for ballistic blocks ejected from Vesuvius during the eruption of 79 A.D.

Published
2006

73. 5: Ballistics Shower During Plinian Scenario at Vesuvius: 5.3. PHYSICAL PROPERTIES OF SAMPLES.

Author

De Novellis, V. and Luongo, G.

Abstract

Section 3 of the Chapter 5 of the book "Vesuvius: Education, Security and Prosperity" is presented. It describes the physical properties of the samples of ballistic blocks during the eruption of 79 A.D. from a quarry at Pozzelle and in archeological sites of Pompeii, Oplonti, Stabia, and Boscoreale on the southern side of the volcano. It discusses the result of a large quarry at Pozzelle and in archeological sites of Pompeii, Oplonti, Stabia, and Boscoreale on the southern side of the volcano

Published
2006

74. 5: Ballistics Shower During Plinian Scenario at Vesuvius: 5.2. BALLISTICS.

Author

De Novellis, V. and Luongo, G.

Abstract

Section 2 of the Chapter 5 of the book "Vesuvius: Education, Security and Prosperity" is presented. It examines the motion of a fragment moving along a ballistic trajectory in a vacuum. It describes the initial phases of extremely explosive eruptions known to produce deposits in which the average block size increases with the distance from the crater.

Published
2006

83. Dietary vitamin D deficiency and development of cardiovascular system

Author

Loffreda, A., primary, Vitagliano, S., additional, de Novellis, V., additional, Losasso, C., additional, De Santis, D., additional, Stella, L., additional, Angrisani, M., additional, Cenicola, M.L., additional, De Paola, C., additional, Matera, C., additional, Falzarano, C., additional, and Guarino, V., additional

Published
1990
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86. Molecular methods for neuropathic pain treatment.

Author

Siniscalco D, Fuccio C, de Novellis V, Rossi F, and Maione S

Abstract

Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. Neuropathic pain has a great impact on the quality of life. It is debilitating and often has an associated degree of depression that contributes to decreasing human wellbeing. In the USA, it has been estimated that about four million people are afflicted by chronic pain each year. Almost all the patients with spinal cord injuries show neuropathic pain problems. Moreover, the management of chronic pain is costly to the health care system. The United States Congress has declared the present decade as the 'Decade of Pain Control and Research.' Neuropathic pain treatment is extremely difficult. Current available therapeutics have a generalized nature, sometime they act on the temporal pain properties rather than targeting the several mechanisms underlying the generation and propagation of pain. Brand new molecular methods, such as gene therapy, stem cell therapy and viral vectors for delivery of biologic antinociceptive molecules, could offer a new therapeutic approach to the treatment of neuropathic pain. [ABSTRACT FROM AUTHOR]

Published
2005
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89. Metabotropic Glutamate and Cannabinoid Receptor Crosstalk in Periaqueductal Grey Pain Processing

Author

Palazzo, E., de Novellis, V., Marabese, I., Rossi, F., and Maione, S.

Abstract

Metabotropic glutamate (mGlu) and cannabinoid receptors are G-protein coupled receptors which have shown synaptic co-operation through small lipid messengers in the central nervous system (CNS). A functional interaction between these two receptor families could have a relevant potential in the treatment of CNS disorders, including chronic pain. Indeed, both mGlu and cannabinoid receptors play a crucial role in the neurobiology of pain and their simultaneous manipulation could lead to novel strategies in pain management. In particular, as both mGlu and cannabinoid receptors have been found in the periaqueductal gray (PAG), a crucial station in the pain modulatory system, these receptors could be a substrate for producing analgesia at this level. In this review we aim to briefly illustrate the role of mGlu and cannabinoid receptors in controlling nociceptive processes, some points of convergence, and their functional interaction in pain processing. Further insights into this functional linkage between the mGlu and cannabinoid receptors could pave the way to a new strategy for pain relief, such as a drug cocktail acting on cannabinoid/metabotropic glutamate receptors.

Published
2006

90. 3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities

Author

Bondavalli, Francesco, Bruno, Olga, Ranise, Angelo, Schenone, P, Russo, S, Loffreda, A, De Novellis, V, Lo Sasso, C, Marmo, E., Bondavalli, F, Bruno, O, Ranise, A, Schenone, P, Russo, S, Loffreda, A, DE NOVELLIS, Vito, LO SASSO, C, and Marmo, E.

Subjects
Blood Platelets, Analgesics, Chemical Phenomena, Anti-Inflammatory Agents, Non-Steroidal, Blood Pressure, Bromine, Rats, Chemistry, Heart Rate, Malondialdehyde, Animals, Pyrazoles, Anesthetics, Local, Anti-Arrhythmia Agents
Abstract

The synthesis of N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives (V) by reaction of primary and secondary amines with the tosylates of 1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole and its 4-bromo derivative is described. Some of compounds (V) showed a remarkable analgesic activity in mice. Moreover, the above compounds usually exhibited moderate hypotensive, bradycardiac and antiinflammatory activities in rats, infiltration anesthesia in mice, as well as a weak platelet antiaggregating activity in vitro.

Published
1988

96. ChemInform Abstract: 3,5‐Diphenyl‐1H‐pyrazole Derivatives. Part. 1. Esters and N‐Substituted Carbamates of 1‐(2‐Hydroxyethyl)‐3,5‐diphenyl‐1H‐pyrazole and Its 4‐Bromo Derivative with Depressant, Antiarrhythmic, Analgesic, and Other Activities.

Author

BONDAVALLI, F., primary, BRUNO, O., additional, RANISE, A., additional, SCHENONE, P., additional, ADDONIZIO, P., additional, DE NOVELLIS, V., additional, LOFFREDA, A., additional, and MARMO, E., additional

Published
1989
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97. 5: Ballistics Shower During Plinian Scenario at Vesuvius: 5.5. CONCLUSION.

Author

De Novellis, V. and Luongo, G.

Abstract

Section 5 of the Chapter 5 of the book "Vesuvius: Education, Security and Prosperity" is presented. It highlights the need for new physical and numerical models which include particle-particle and gas-particles interactions to be developed for a more complete understanding of the dispersion and fall characteristics of volcanic products. It cites the new volcanological data pertaining to the ballistic motions of particles ejected from Vesuvius.

Published
2006

98. 5: Ballistics Shower During Plinian Scenario at Vesuvius: 5.1. INTRODUCTION.

Author

De Novellis, V. and Luongo, G.

Abstract

Section 1 of the Chapter 5 of the book "Vesuvius: Education, Security and Prosperity" is presented. It presents present additional insights into the explosiveness of the 79 A.D. plinian eruption of Vesuvius on the basis of an analysis of the explosion mechanism. It cites the importance of a more detailed knowledge of the ballistic processes that interact in transport and deposition mechanisms of pyroclastic products.

Published
2006

99. 5: Ballistics Shower During Plinian Scenario at Vesuvius: RIASSUNTO.

Author

De Novellis, V. and Luongo, G.

Abstract

Copyright of VESUVIUS: Education, Security & Prosperity is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2006

100. 5: Ballistics Shower During Plinian Scenario at Vesuvius: ABSTRACT.

Author

De Novellis, V. and Luongo, G.

Abstract

The distribution of pyroclasts from 79 A.D. eruption of Vesuvius is analysed to assess the ejection velocities of ballistic particles pertaining to the white and gray eruption phases. This distribution is related to the energy of the eruptive mixture and conditions of the atmosphere during the eruption. Ballistic debris is common in the deposits, and within the sampled area (3-14km S-SE from the vent) the ejected blocks are scattered throughout the fine-grained pumice fall. We measured about 300 ballistic blocks with diameters between 0.07 and 1 m. Some fragments as large as 0.3m are located at 9km from the vent, which probably represents the ballistic limit of such fragments. By using a ballistic model for large blocks permitted an assessment of their initial velocities which range from 170 to 2300 m/s, and since some of these velocities exceed the maximum observed velocities of plinian eruptions we conclude that the ballistic model is deficient. The trajectories of smaller blocks (0.1

Published
2006

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